PMC:2726282 / 13147-14307 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2726282","sourcedb":"PMC","sourceid":"2726282","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2726282","text":"Furthermore, a relatively high proportion of the downstream specialised TFs autoactivate themselves (see below), a feature that is rare at the level of the whole transcriptional network. In addition, we could identify 105 multi-element circuits in the transcriptional regulatory network involving 2 to 14 different elements (including transcription and sigma factors, see Fig. 3 and supplementary material for the complete list of circuits). Interestingly, the information fluxes inside these circuits follow a frequent route in the network with the order CsgD \u003e Cspa \u003e HNS \u003e GadX \u003e RpoS \u003e IHF. From IHF the regulatory flow diverge in two main directions: IHF \u003e RpoH \u003e RpoD and IHF \u003e FIS \u003e CRP. In line with this observation, CRP and RpoD are the major distributors, whereas CsgD and GadX are the main collectors of information. These multi-element circuits inside the cross-regulatory network are novel observations. The functional relevance of these regulatory structures remains to be assessed experimentally. Tentatively, these circuits may implement a feedback between the presence of different stresses and the basic machinery for replication and growth.","tracks":[]}