PMC:2726282 / 11543-12192 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2726282","sourcedb":"PMC","sourceid":"2726282","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2726282","text":"When glucose is lacking, cAMP level increases and CRP can activate the transcription of genes responsible for degrading alternative carbon sources.27 Simultaneously, sugars (or a processed variant thereof) present in the cell bind their specific TF; allosteric interactions then result in TF unbinding from DNA, alleviating the repression and permitting the transcription of the corresponding target genes. This organisation involving multiple parallel FFLs coupled to phosphotransferase activity appears optimal for enabling rapid transcriptional responses to sudden lack of glucose in the presence of alternative carbon sources in the milieu.28,29","tracks":[{"project":"2_test","denotations":[{"id":"18599074-17158705-62517927","span":{"begin":147,"end":149},"obj":"17158705"},{"id":"18599074-16406067-62517928","span":{"begin":647,"end":649},"obj":"16406067"},{"id":"18599074-16204860-62517928","span":{"begin":647,"end":649},"obj":"16204860"}],"attributes":[{"subj":"18599074-17158705-62517927","pred":"source","obj":"2_test"},{"subj":"18599074-16406067-62517928","pred":"source","obj":"2_test"},{"subj":"18599074-16204860-62517928","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec9397","default":true}]}]}}