PMC:2725236 / 15093-17081
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2725236","sourcedb":"PMC","sourceid":"2725236","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2725236","text":"A recent genome-wide association study of ADHD listed a SNP (rs10514604; p = 8 × 10−7) in ATP2C2 within the top 30 significant associations.32 Despite distinct defining characteristics, ADHD and SLI show a high level of comorbidity both with each other32 and with disorders such as developmental coordination disorder, speech-sound disorder (SSD; MIM #608445), and dyslexia.33–35 For example, individuals with SLI, SSD, ADHD, or dyslexia often present with linguistic deficits and impairments in short-term memory.33 It has therefore been suggested that certain aspects of these disorders might share a common etiology. Given the high levels of co-occurrence, we did not exclude children affected by ADHD and dyslexia from our study samples. However, in some of our SLIC samples, data were available for the presence of hyperactivity, coordination, and reading problems. From this, we estimate that approximately one-third of our SLIC samples showed some evidence of ADHD or developmental coordination disorder and that approximately one-half of our probands had reading problems. In the entire ASLPAC sample, 1.3% of individuals met criteria for ADHD. In the selected ALSPAC replication sample, the rate of ADHD increased to 3.7%. Thus, as expected, it is clear that the rate of developmental disorders across our cohorts is elevated over that expected in a population sample. Nonetheless, the association detected in our samples shows a strong correlation to nonword-repetition ability which has repeatedly been shown to be a strong indicator of language impairment.9,10 Furthermore, in ADHD samples, performance on the nonword-repetition task is correlated with linguistic ability rather than the presence of hyperactivity.33,36 Thus, we conclude that variants in ATP2C2 might account for shared aspects of the linguistic deficit in SLI and ADHD. Given this possibility, we also postulate that ATP2C2 might contribute to phonological short-term memory in other developmental disorders.","tracks":[{"project":"2_test","denotations":[{"id":"19646677-18839057-2044581","span":{"begin":140,"end":142},"obj":"18839057"},{"id":"19646677-18839057-2044582","span":{"begin":252,"end":254},"obj":"18839057"},{"id":"19646677-10784082-2044583","span":{"begin":377,"end":379},"obj":"10784082"},{"id":"19646677-18652545-2044583","span":{"begin":377,"end":379},"obj":"18652545"},{"id":"19646677-18608219-2044583","span":{"begin":377,"end":379},"obj":"18608219"},{"id":"19646677-10784082-2044584","span":{"begin":514,"end":516},"obj":"10784082"},{"id":"19646677-17853238-2044585","span":{"begin":1570,"end":1572},"obj":"17853238"},{"id":"19646677-10784082-2044586","span":{"begin":1729,"end":1731},"obj":"10784082"},{"id":"19646677-16405635-2044586","span":{"begin":1729,"end":1731},"obj":"16405635"}],"attributes":[{"subj":"19646677-18839057-2044581","pred":"source","obj":"2_test"},{"subj":"19646677-18839057-2044582","pred":"source","obj":"2_test"},{"subj":"19646677-10784082-2044583","pred":"source","obj":"2_test"},{"subj":"19646677-18652545-2044583","pred":"source","obj":"2_test"},{"subj":"19646677-18608219-2044583","pred":"source","obj":"2_test"},{"subj":"19646677-10784082-2044584","pred":"source","obj":"2_test"},{"subj":"19646677-17853238-2044585","pred":"source","obj":"2_test"},{"subj":"19646677-10784082-2044586","pred":"source","obj":"2_test"},{"subj":"19646677-16405635-2044586","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ae93ec","default":true}]}]}}