PMC:2724631 / 5559-7034 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2724631","sourcedb":"PMC","sourceid":"2724631","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2724631","text":"Cooper and Kernohan in a pathologic study of heterotopic cell rests and leptomeningeal gliomas found no attachment of the extramedullary tumor to the underlying parenchyma, no evidence of a primary neoplastic process within the neuraxis, and many of the tumors were encapsulated by a leptomeningeal sheath [9]. Chen et al. proposed that a diagnosis can only be established after a complete neuroanatomical examination, which includes postmortem examination of the brain and spinal cord, a gross inspection of representative thin sections from the entire neuraxis, and a microscopic examination of all areas that raise the suspicion of pial disruption during gross examination [7]. These criteria rely on autopsy data to determine a postmortem diagnosis; hence making a clinical diagnosis continues to remain difficult. Due to the nonspecific and variable clinical presentation many cases have been diagnosed and managed as tuberculous meningitis with the diagnosis of PDLG made only at late stages or postmortem [1, 2]. Since the characteristic MRI finding is that of a diffuse contrast enhancing process chronic meningitis needs to be ruled out. Therefore, a biopsy is necessary in the work up of the patient. Due to the paucity of reported cases in the literature the optimum treatment plan for PDLG or PLO is unknown. Our decision to use cranial radiation and chemotherapy was empiric after discussion with the patient as well as experts from our and outside institutions.","tracks":[{"project":"2_test","denotations":[{"id":"19290482-14804124-63243932","span":{"begin":307,"end":308},"obj":"14804124"},{"id":"19290482-7674024-63243933","span":{"begin":677,"end":678},"obj":"7674024"},{"id":"19290482-16431108-63243934","span":{"begin":1013,"end":1014},"obj":"16431108"},{"id":"19290482-16488248-63243935","span":{"begin":1016,"end":1017},"obj":"16488248"}],"attributes":[{"subj":"19290482-14804124-63243932","pred":"source","obj":"2_test"},{"subj":"19290482-7674024-63243933","pred":"source","obj":"2_test"},{"subj":"19290482-16431108-63243934","pred":"source","obj":"2_test"},{"subj":"19290482-16488248-63243935","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ccec93","default":true}]}]}}