PMC:2724173 / 8832-9454 JSONTXT

{"project":"2_test","denotations":[{"id":"18304577-11551174-62526547","span":{"begin":306,"end":308},"obj":"11551174"},{"id":"18304577-17064953-62526548","span":{"begin":620,"end":622},"obj":"17064953"},{"id":"18304577-17496915-62526548","span":{"begin":620,"end":622},"obj":"17496915"}],"text":"The structural similarity between the domains of MxiC suggests that they might be the product of gene duplication events. Such internal repetition arising via intragenic duplication and recombination events has been a successful stratagem throughout evolution for enlargement of the available surface area.20 This, combined with the elongated shape of MxiC, provides the maximal exposure of surface area and considerable binding interfaces suitable for large substrates, linear peptides or multiple partners. This feature is typical of scaffolding proteins that act to recruit multiple proteins and enhance signaling.21,22"}