PMC:2724026 / 5519-6787 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2724026","sourcedb":"PMC","sourceid":"2724026","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2724026","text":"In the Ig-like domains, two elements of structure, twisted beta sheets, pack together to form the hydrophobic core. Central to this structure is a four-strand motif consisting of two pairs of anti-parallel beta strands, one from each sheet (B-E and C-F, Fig. 1). Similarly, death domains can be thought of as two three-helix bundles, packed together via a central four-helix motif: bundle 1 (B1) is made from the packing of H1, H5 and H6, and forms the B1 core. Bundle 2 is made of contiguous helices H2, H3 and H4, which pack to form the B2 core. The central four-helix motif comprises two pairs of parallel helices (H1-H5 and H2-H4) packed together orthogonally, to form the central core. As is shown in Fig. 1, the three cores are clearly separated, so that different faces of H1, H2, H4 and H5 contribute to different cores. The peripheral helices H3 and H6 contribute only to the packing of the bundle cores (B2 and B1, respectively). In contrast, the Ig-like domains have a single hydrophobic core formed by packing of the twisted beta sheets. Thus, FADD DD can be thought of as two spectrin-like, three-helix bundles packed together to form a Greek key structure with central elements forming the central core in a manner that is reminiscent of Ig-like domains.","tracks":[]}