PMC:2724026 / 39411-40546 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/2724026","sourcedb":"PMC","sourceid":"2724026","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2724026","text":"FADD DD variant Core probed by mutation ΔGD-N (kcal mol-1) ΔΔGD-N (kcal mol-1) mD-N (kcal mol-1 M-1) kf2M (s-1) Φ2M\nWT 6.7 1.4 40\nHelix1\nPhe101Ala Central 4.2 2.6 1.6 10 0.31\nVal103Ala B1 5.3 1.4 1.2 36 0.04\nIle104Ala Central 4.3 2.4 1.1 12 0.29\nHelix2\nTrp112Ala B2 2.8 3.9 1.4 10 0.18\nLeu115Met Central 5.1 2.4 1.4 22 0.22\nLeu119Met Central 4.3 1.6 1.3 28 0.10\nHelix3\nIle126Ala B2 5.6 1.2 1.2 36 0.05\nIle129Ala B2 4.5 2.2 1.5 43 –0.02\nTyr133Ala B2 4.5 2.2 1.1 39 0.01\nHelix4\nArg140Ala B2 7.3 –0.6 1.1 72 0.60\nVal141Ala Central 5.5 1.3 1.3 14 0.51\nSer144Ala B2 7.4 – 0.7 2.1 114 0.86\nLeu145Met Central 4.5 2.3 1.4 23 0.15\nTrp148Phe Central 3.6 3.1 1.4 55 –0.06\nHelix5\nHis160Ala Central 7.7 –1.0 1.3 80 0.40\nLeu161Ala Central 2.9 3.9 1.6 4 0.37\nVal162Ala B1 4.9 1.9 1.5 16 0.29\nLeu165Ala B1 2.8 3.9 1.6 7 0.26\nCys168Ala Central 6.4 0.4 1.4 42 n.d.\nHelix6\nVal173Ala B1 5.2 1.1 1.4 29 0.17\nLeu176Ala B1 6.0 0.8 1.3 25 0.37\nVal177Ala B1 4.0 2.7 1.4 24 0.11\nVal180Ala B1 6.8 –0.1 1.2 47 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