PMC:2724026 / 27159-27585 JSONTXT

{"project":"2_test","denotations":[{"id":"19362094-9545386-62520539","span":{"begin":424,"end":426},"obj":"9545386"}],"text":"Although FADD DD and TNfn3 have similar stabilities, and appear to have similar folding mechanisms, FADD DD folds significantly faster than TNfn3 (∼ 1000 s- 1 compared to 6 s- 1). This is not unexpected; FADD DD is an all alpha-helical protein with a significantly lower relative contact order than the all-beta TNfn3, and it has been shown that proteins with low contact orders generally have higher folding rate constants.44"}