PMC:2700745 / 49191-50185
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2700745","sourcedb":"PMC","sourceid":"2700745","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2700745","text":"Ferrets have been used extensively to study the infectivity and virulence of influenza virus mutants resistant to the neuraminidase inhibitors (Blick et al., 1998, Gubareva et al., 1998b, Barnett et al., 2000). Blick et al. (1998) found that a zanamivir-resistant influenza virus with an NA and HA mutation was not resistant to zanamivir in ferrets, even though a small decrease in sensitivity to the drug had been shown in mice, indicating some potential differences in the two models when studying drug-resistant viruses. A summary of current animal models available for studying drug-resistant influenza virus infections is presented in Table 8 .\nTable 8 Summary of current animal models available for studying drug-resistant influenza virus infections.\nVirus Animal Model Drug References\nInfluenza A H4N2 Mouse (BALB/CBYJ) Neuraminidase inhibitors Gubareva et al. (1997)\nA/turkey/Minnesota/833/80\n\u2028\u2028\nInfluenza A H1N1 Mouse (C57BL6 X C57BL10) Ferret Zanamivir Blick et al. (1998)\nNWS/G70C4-G","divisions":[{"label":"label","span":{"begin":650,"end":657}},{"label":"caption","span":{"begin":658,"end":756}},{"label":"p","span":{"begin":658,"end":756}},{"label":"tr","span":{"begin":757,"end":791}},{"label":"th","span":{"begin":757,"end":762}},{"label":"th","span":{"begin":763,"end":775}},{"label":"th","span":{"begin":776,"end":780}},{"label":"th","span":{"begin":781,"end":791}},{"label":"tr","span":{"begin":792,"end":874}},{"label":"td","span":{"begin":792,"end":808}},{"label":"td","span":{"begin":809,"end":826}},{"label":"td","span":{"begin":827,"end":851}},{"label":"td","span":{"begin":852,"end":874}},{"label":"tr","span":{"begin":875,"end":900}},{"label":"td","span":{"begin":875,"end":900}},{"label":"tr","span":{"begin":901,"end":903}},{"label":"td","span":{"begin":901,"end":903}},{"label":"tr","span":{"begin":904,"end":982}},{"label":"td","span":{"begin":904,"end":920}},{"label":"td","span":{"begin":921,"end":952}},{"label":"td","span":{"begin":953,"end":962}},{"label":"td","span":{"begin":963,"end":982}}],"tracks":[{"project":"2_test","denotations":[{"id":"19176218-9656997-100518403","span":{"begin":158,"end":162},"obj":"9656997"},{"id":"19176218-9656997-100518403","span":{"begin":158,"end":162},"obj":"9656997"},{"id":"19176218-10602727-100518405","span":{"begin":204,"end":208},"obj":"10602727"},{"id":"19176218-10602727-100518405","span":{"begin":204,"end":208},"obj":"10602727"},{"id":"19176218-9656997-3579337","span":{"begin":225,"end":229},"obj":"9656997"},{"id":"19176218-9656997-3579337","span":{"begin":225,"end":229},"obj":"9656997"},{"id":"19176218-9656997-3579334","span":{"begin":158,"end":162},"obj":"9656997"},{"id":"19176218-9656997-3579334","span":{"begin":158,"end":162},"obj":"9656997"},{"id":"19176218-10602727-3579336","span":{"begin":204,"end":208},"obj":"10602727"},{"id":"19176218-10602727-3579336","span":{"begin":204,"end":208},"obj":"10602727"},{"id":"T66490","span":{"begin":225,"end":229},"obj":"9656997"},{"id":"T20568","span":{"begin":225,"end":229},"obj":"9656997"},{"id":"19176218-9094607-3579338","span":{"begin":869,"end":873},"obj":"9094607"},{"id":"19176218-9094607-3579338","span":{"begin":869,"end":873},"obj":"9094607"},{"id":"19176218-9656997-3579339","span":{"begin":977,"end":981},"obj":"9656997"},{"id":"19176218-9656997-3579339","span":{"begin":977,"end":981},"obj":"9656997"}],"attributes":[{"subj":"19176218-9656997-100518403","pred":"source","obj":"2_test"},{"subj":"19176218-9656997-100518403","pred":"source","obj":"2_test"},{"subj":"19176218-10602727-100518405","pred":"source","obj":"2_test"},{"subj":"19176218-10602727-100518405","pred":"source","obj":"2_test"},{"subj":"19176218-9656997-3579337","pred":"source","obj":"2_test"},{"subj":"19176218-9656997-3579337","pred":"source","obj":"2_test"},{"subj":"19176218-9656997-3579334","pred":"source","obj":"2_test"},{"subj":"19176218-9656997-3579334","pred":"source","obj":"2_test"},{"subj":"19176218-10602727-3579336","pred":"source","obj":"2_test"},{"subj":"19176218-10602727-3579336","pred":"source","obj":"2_test"},{"subj":"T66490","pred":"source","obj":"2_test"},{"subj":"T20568","pred":"source","obj":"2_test"},{"subj":"19176218-9094607-3579338","pred":"source","obj":"2_test"},{"subj":"19176218-9094607-3579338","pred":"source","obj":"2_test"},{"subj":"19176218-9656997-3579339","pred":"source","obj":"2_test"},{"subj":"19176218-9656997-3579339","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#b6ec93","default":true}]}]}}