PMC:2700745 / 45704-46307 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2700745","sourcedb":"PMC","sourceid":"2700745","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2700745","text":"Mori et al. (2002) have used a highly neurovirulent recombinant R404BP strain of influenza A (H1N1) virus to test amantadine therapy in mice. Stereotaxic microinjection of virus into the olfactory bulb of the animal results in outward spread to neurons in broad areas of the brain parenchyma, leading to apoptotic neurogeneration and fatal edema, beginning on day 8. However, amantadine treatment beginning as late as 7 days after virus injection protected the animals. The disadvantage of this clinically relevant model is that only researchers having stereotaxic microinjection equipment could use it.","tracks":[{"project":"2_test","denotations":[{"id":"19176218-12490390-3579320","span":{"begin":13,"end":17},"obj":"12490390"},{"id":"19176218-12490390-3579320","span":{"begin":13,"end":17},"obj":"12490390"},{"id":"T33290","span":{"begin":13,"end":17},"obj":"12490390"},{"id":"T95591","span":{"begin":13,"end":17},"obj":"12490390"}],"attributes":[{"subj":"19176218-12490390-3579320","pred":"source","obj":"2_test"},{"subj":"19176218-12490390-3579320","pred":"source","obj":"2_test"},{"subj":"T33290","pred":"source","obj":"2_test"},{"subj":"T95591","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecaa","default":true}]}]}}