PMC:2700745 / 35874-36361 JSONTXT

{"project":"2_test","denotations":[{"id":"19176218-18670648-100518368","span":{"begin":288,"end":292},"obj":"18670648"},{"id":"19176218-18670648-100518368","span":{"begin":288,"end":292},"obj":"18670648"},{"id":"19176218-17182684-100518369","span":{"begin":481,"end":485},"obj":"17182684"},{"id":"19176218-17182684-100518369","span":{"begin":481,"end":485},"obj":"17182684"},{"id":"19176218-18670648-3579275","span":{"begin":288,"end":292},"obj":"18670648"},{"id":"19176218-18670648-3579275","span":{"begin":288,"end":292},"obj":"18670648"},{"id":"19176218-17182684-3579276","span":{"begin":481,"end":485},"obj":"17182684"},{"id":"19176218-17182684-3579276","span":{"begin":481,"end":485},"obj":"17182684"}],"text":"In another study, a recent H5N1 isolate was shown to promote significantly higher levels of pro-inflammatory cytokines in whole lungs and primary human macrophages probably resulting in early and excessive infiltration of macrophages and neutrophils in the lungs of mice (Perrone et al., 2008). Another study has suggested that in addition to the typical proinflammatory cytokines, TNF-α may also contribute to the morbidity during H5N1 influenza virus infection (Szretter et al., 2007)."}