PMC:2700745 / 29275-30550 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2700745","sourcedb":"PMC","sourceid":"2700745","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2700745","text":"A bacterial superinfection model was also established in ferrets, in which influenza more closely resembles that found in humans (Peltola et al., 2006). The goals of the study were to better understand the various sequelae of S. pneumoniae infection, including otitis media, sinusitis, and pneumonia, and to determine if the frequency and character of secondary pneumococcal infections differed depending on the strain of influenza virus that preceded bacterial challenge, as has been reported in humans. The viruses studied were A/Taiwan/1/86 (H1N1), the H3N2 viruses A/Sydney/5/97 and A/Fujian/411/02, and influenza B virus B/Singapore/222/79. In seven-week-old ferrets inoculated intranasally with virus and 5 days later with S. pneumoniae, all viruses increased bacterial colonization of the nasopharynx. However, 9 of 10 ferrets infected with H3N2 subtype influenza A viruses developed either sinusitis or otitis media, while only 1 of 11 infected with an H1N1 virus or an influenza B virus did so. These data support observations in humans that bacterial complication rates are higher during seasons when H3N2 viruses predominate (Bhat et al., 2005). This animal model could be useful for further study of the mechanisms that underlie viral–bacterial disease synergism.","tracks":[{"project":"2_test","denotations":[{"id":"19176218-16622191-3579238","span":{"begin":146,"end":150},"obj":"16622191"},{"id":"19176218-16622191-3579238","span":{"begin":146,"end":150},"obj":"16622191"},{"id":"19176218-16354892-100518356","span":{"begin":1150,"end":1154},"obj":"16354892"},{"id":"19176218-16354892-100518356","span":{"begin":1150,"end":1154},"obj":"16354892"},{"id":"T72231","span":{"begin":146,"end":150},"obj":"16622191"},{"id":"T37418","span":{"begin":146,"end":150},"obj":"16622191"}],"attributes":[{"subj":"19176218-16622191-3579238","pred":"source","obj":"2_test"},{"subj":"19176218-16622191-3579238","pred":"source","obj":"2_test"},{"subj":"19176218-16354892-100518356","pred":"source","obj":"2_test"},{"subj":"19176218-16354892-100518356","pred":"source","obj":"2_test"},{"subj":"T72231","pred":"source","obj":"2_test"},{"subj":"T37418","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#b993ec","default":true}]}]}}