PMC:2700745 / 27905-28612 JSONTXT

{"project":"2_test","denotations":[{"id":"19176218-17348295-3579236","span":{"begin":216,"end":220},"obj":"17348295"},{"id":"19176218-17348295-3579236","span":{"begin":216,"end":220},"obj":"17348295"},{"id":"T35750","span":{"begin":216,"end":220},"obj":"17348295"},{"id":"T37600","span":{"begin":216,"end":220},"obj":"17348295"}],"text":"In another model of secondary pneumococcal pneumonia during influenza A virus infection, the pathology and immunology that led to fatal disease was studied by specifically looking at cytokine profiles (Smith et al., 2007). Influenza-infected mice challenged with each of 3 serotypes of S. pneumoniae developed a severe, necrotic pneumonia, characterized by markedly elevated levels of both pro- and anti-inflammatory molecules in the lungs, accompanied by a massive influx of neutrophils. Death was associated with the development of pneumonia and lung inflammation, but not with bacteremia. Thus, this model may be used to delineate factors associated with the pathogenesis of severe mixed lung infections."}