PMC:2700745 / 23800-24909
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/2700745","sourcedb":"PMC","sourceid":"2700745","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2700745","text":"The influenza A cotton rat model is a nasal and pulmonary infection in adult inbred cotton rats. Animals infected intranasally with doses of a recent H3N2 influenza strain had increased breathing rates accompanied by weight loss and decreased temperature (Ottolini et al., 2005). Virus replication peaked within 24 h in the lung, with peak titers proportional to the infecting dose. Although virus was cleared from the lung by day 3, replication persisted in nasal tissues for 6 days. Pulmonary pathology included early bronchiolar epithelial cell damage, followed by extensive alveolar and interstitial pneumonia detectable in animals for up to about three weeks. Cytokine levels were typical of an inflammatory response to a lung infection; their upregulation appeared to coincide with increased virus replication. Since this model has not been gained wide acceptance due to the limitations described above, there are a paucity of papers using cotton rats to vaccine efficacy (Straight et al., 2008) and antiviral efficacy (Eichelberger et al., 2004, Stertz et al., 2007) against influenza virus infections.","tracks":[{"project":"2_test","denotations":[{"id":"19176218-16186238-100518348","span":{"begin":273,"end":277},"obj":"16186238"},{"id":"19176218-16186238-100518348","span":{"begin":273,"end":277},"obj":"16186238"},{"id":"19176218-18355405-100518349","span":{"begin":996,"end":1000},"obj":"18355405"},{"id":"19176218-18355405-100518349","span":{"begin":996,"end":1000},"obj":"18355405"},{"id":"19176218-15110527-100518350","span":{"begin":1047,"end":1051},"obj":"15110527"},{"id":"19176218-15110527-100518350","span":{"begin":1047,"end":1051},"obj":"15110527"},{"id":"19176218-17970694-100518351","span":{"begin":1068,"end":1072},"obj":"17970694"},{"id":"19176218-17970694-100518351","span":{"begin":1068,"end":1072},"obj":"17970694"},{"id":"19176218-16186238-3579216","span":{"begin":273,"end":277},"obj":"16186238"},{"id":"19176218-16186238-3579216","span":{"begin":273,"end":277},"obj":"16186238"},{"id":"19176218-18355405-3579217","span":{"begin":996,"end":1000},"obj":"18355405"},{"id":"19176218-18355405-3579217","span":{"begin":996,"end":1000},"obj":"18355405"},{"id":"19176218-15110527-3579218","span":{"begin":1047,"end":1051},"obj":"15110527"},{"id":"19176218-15110527-3579218","span":{"begin":1047,"end":1051},"obj":"15110527"},{"id":"19176218-17970694-3579219","span":{"begin":1068,"end":1072},"obj":"17970694"},{"id":"19176218-17970694-3579219","span":{"begin":1068,"end":1072},"obj":"17970694"}],"attributes":[{"subj":"19176218-16186238-100518348","pred":"source","obj":"2_test"},{"subj":"19176218-16186238-100518348","pred":"source","obj":"2_test"},{"subj":"19176218-18355405-100518349","pred":"source","obj":"2_test"},{"subj":"19176218-18355405-100518349","pred":"source","obj":"2_test"},{"subj":"19176218-15110527-100518350","pred":"source","obj":"2_test"},{"subj":"19176218-15110527-100518350","pred":"source","obj":"2_test"},{"subj":"19176218-17970694-100518351","pred":"source","obj":"2_test"},{"subj":"19176218-17970694-100518351","pred":"source","obj":"2_test"},{"subj":"19176218-16186238-3579216","pred":"source","obj":"2_test"},{"subj":"19176218-16186238-3579216","pred":"source","obj":"2_test"},{"subj":"19176218-18355405-3579217","pred":"source","obj":"2_test"},{"subj":"19176218-18355405-3579217","pred":"source","obj":"2_test"},{"subj":"19176218-15110527-3579218","pred":"source","obj":"2_test"},{"subj":"19176218-15110527-3579218","pred":"source","obj":"2_test"},{"subj":"19176218-17970694-3579219","pred":"source","obj":"2_test"},{"subj":"19176218-17970694-3579219","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93b0ec","default":true}]}]}}