PMC:2700745 / 23220-23799 JSONTXT

{"project":"2_test","denotations":[{"id":"19176218-17603841-3579215","span":{"begin":446,"end":450},"obj":"17603841"},{"id":"19176218-17603841-3579215","span":{"begin":446,"end":450},"obj":"17603841"},{"id":"T46915","span":{"begin":446,"end":450},"obj":"17603841"},{"id":"T43410","span":{"begin":446,"end":450},"obj":"17603841"}],"text":"Cotton rats (Sigmodon hispidus) have several advantages over mice and ferrets as a model for human influenza, including the availability of reagents to study immunological responses. When compared to mice of any strain, cotton rats appear to have all the innate and adaptive immune responses seen in humans, such as Mx gene-mediated responses. Viruses isolated from humans do not have to be adapted to cotton rats to cause disease (Eichelberger, 2007). The disadvantages of the cotton rat are primarily animal availability and the aggressiveness of species, regardless of gender."}