PMC:2700745 / 19383-20166 JSONTXT

{"project":"2_test","denotations":[{"id":"19176218-11080536-3579191","span":{"begin":287,"end":291},"obj":"11080536"},{"id":"19176218-11080536-3579191","span":{"begin":287,"end":291},"obj":"11080536"},{"id":"19176218-16186238-100518325","span":{"begin":753,"end":757},"obj":"16186238"},{"id":"19176218-16186238-100518325","span":{"begin":753,"end":757},"obj":"16186238"},{"id":"19176218-11080536-100518326","span":{"begin":777,"end":781},"obj":"11080536"},{"id":"19176218-11080536-100518326","span":{"begin":777,"end":781},"obj":"11080536"},{"id":"T63519","span":{"begin":287,"end":291},"obj":"11080536"},{"id":"T61456","span":{"begin":287,"end":291},"obj":"11080536"},{"id":"19176218-16186238-3579192","span":{"begin":753,"end":757},"obj":"16186238"},{"id":"19176218-16186238-3579192","span":{"begin":753,"end":757},"obj":"16186238"},{"id":"19176218-11080536-3579193","span":{"begin":777,"end":781},"obj":"11080536"},{"id":"19176218-11080536-3579193","span":{"begin":777,"end":781},"obj":"11080536"}],"text":"A number of parameters may be used to monitor influenza virus infection in mice, including change in body weight, decline in arterial oxygen saturation, increase in serum alpha-1-acid glycoprotein, mean time to death, and lung weight, viral titer and pathology scores (Sidwell and Smee, 2000). Disease manifestations often depend on the infectivity and challenge dose of the virus and (for seasonal influenza virus strains) how well the virus has adapted to the host. If a virus replicates in mice without causing apparent illness, the effects of therapy can be monitored using parameters such as lung viral titers, increase in lung weight and increase in 1-acid glycoprotein (1-AG), all of which increase in nonlethally infected mice (Ottolini et al., 2005, Sidwell and Smee, 2000)."}