PMC:2700745 / 17601-18401 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2700745","sourcedb":"PMC","sourceid":"2700745","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2700745","text":"In cases of severe influenza pneumonia in humans, histological changes in the lungs include capillary and small vessel thromboses, necrotizing bronchitis and bronchiolitis, interstitial edema and inflammatory infiltrates, the formation of hyaline membranes in alveoli and alveolar ducts, varying degrees of acute edema between the alveoli with or without hemorrhaging, and diffuse alveolar damage. The later stages of the disease are characterized by organizing diffuse alveolar damage, fibrosis, epithelial regeneration, and squamous metaplasia. If concomitant bacterial or fungal infection is present, there may be pronounced neutrophil infiltration into alveolar air spaces, with a lesser degree of alveolar hemorrhage and edema than in primary influenza pneumonia (Taubenberger and Morens, 2008).","tracks":[]}