PMC:2700745 / 16421-17600
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/2700745","sourcedb":"PMC","sourceid":"2700745","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2700745","text":"Occasionally in healthy individuals, but much more often in the very young, the elderly, and the immunocompromised, acute seasonal influenza develops into hemorrhagic bronchitis and viral pneumonia, characterized by dyspnea, hemoptysis, pulmonary edema and cyanosis. Death can occur within 48 h after the onset of symptoms. A summary of animal models available to study such infections is presented in Table 3 .\nTable 3 Summary of currently available animal models for studying severe seasonal influenza pneumonia.\nVirus Animal Model References\nInfluenza A H3N2 strains Mouse (BALB/c) Reviewed by Sidwell and Smee (2000)\nA/Shangdong/09/93\nA/Victoria/3/79\n\u2028\u2028\nInfluenza B strains\nB/HongKong/5/72\nB/Lee/40\n\u2028\u2028\nB/Sichuan/379/99 BALB/c Smee et al. (2006)\nInfluenza A H1N1 strains BALB/c Smee et al. (2008)\nA/WSN/33 (H1N1) virus containing the HA gene of A/New Caledonia/20/99\n\u2028\u2028\nA/New Caledonia/20/99 BALB/c Smee et al. (2006)\n\u2028\u2028\nInfluenza A strains\nA/Charlottesville/31/95 (H1N1) Ferret Smee et al. (2008)\n\u2028\u2028\nA/USSR/90/77 (H1N1) Ferret Svitek et al. (2008)\nA/Port Chalmers/1/73 (H3N2)\n\u2028\u2028\nInfluenza A H3N2 A/Wuhan/359/95 Cotton Rat Ottolini et al. 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