PMC:2678986 / 40770-42067
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2678986","sourcedb":"PMC","sourceid":"2678986","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2678986","text":"Information regarding the interaction of anti-HIV drugs with recently discovered novel transporters such as URAT1 and RST are also needed, in order to acquire a complete picture of the impediments that restrict anti-HIV drug transport across the brain barriers. Conversely, the interaction between newer drugs, such as Enfuvirtide and Maraviroc, and transporters also should be fully investigated. Additionally, it would be valuable to explore whether those transporters that have altered expression during HIV infection affect the penetration of HAART across the brain barriers, and if so, whether this can be pharmacologically modulated. Modulating transporters is one method by which drug delivery into the brain could be improved (Miller et al., 2008). Thus rather than modifying substances in order to allow them to penetrate the BBB, a reasonable alternative strategy would be to modify the permeability of the BBB. Recent studies have explored factors responsible for the modulation of P-glycoprotein, Mrp2 and BCRP and the signalling mechanisms responsible for this (Bauer et al., 2004; Imai et al., 2005; Wang et al., 2006). Furthermore, although studies have revealed that the integrity of the BBB is affected during HIV, possible strategies to prevent this have not yet been determined.","tracks":[{"project":"2_test","denotations":[{"id":"19176219-18560012-99578400","span":{"begin":750,"end":754},"obj":"18560012"},{"id":"19176219-18560012-99578400","span":{"begin":750,"end":754},"obj":"18560012"},{"id":"19176219-15322232-99578401","span":{"begin":1089,"end":1093},"obj":"15322232"},{"id":"19176219-15322232-99578401","span":{"begin":1089,"end":1093},"obj":"15322232"},{"id":"19176219-15695404-99578402","span":{"begin":1108,"end":1112},"obj":"15695404"},{"id":"19176219-15695404-99578402","span":{"begin":1108,"end":1112},"obj":"15695404"},{"id":"19176219-16352672-99578403","span":{"begin":1127,"end":1131},"obj":"16352672"},{"id":"19176219-16352672-99578403","span":{"begin":1127,"end":1131},"obj":"16352672"},{"id":"19176219-18560012-3577028","span":{"begin":750,"end":754},"obj":"18560012"},{"id":"19176219-18560012-3577028","span":{"begin":750,"end":754},"obj":"18560012"},{"id":"19176219-15322232-3577029","span":{"begin":1127,"end":1131},"obj":"15322232"},{"id":"19176219-15322232-3577029","span":{"begin":1127,"end":1131},"obj":"15322232"},{"id":"19176219-15695404-3577029","span":{"begin":1127,"end":1131},"obj":"15695404"},{"id":"19176219-15695404-3577029","span":{"begin":1127,"end":1131},"obj":"15695404"},{"id":"19176219-16352672-3577029","span":{"begin":1127,"end":1131},"obj":"16352672"},{"id":"19176219-16352672-3577029","span":{"begin":1127,"end":1131},"obj":"16352672"}],"attributes":[{"subj":"19176219-18560012-99578400","pred":"source","obj":"2_test"},{"subj":"19176219-18560012-99578400","pred":"source","obj":"2_test"},{"subj":"19176219-15322232-99578401","pred":"source","obj":"2_test"},{"subj":"19176219-15322232-99578401","pred":"source","obj":"2_test"},{"subj":"19176219-15695404-99578402","pred":"source","obj":"2_test"},{"subj":"19176219-15695404-99578402","pred":"source","obj":"2_test"},{"subj":"19176219-16352672-99578403","pred":"source","obj":"2_test"},{"subj":"19176219-16352672-99578403","pred":"source","obj":"2_test"},{"subj":"19176219-18560012-3577028","pred":"source","obj":"2_test"},{"subj":"19176219-18560012-3577028","pred":"source","obj":"2_test"},{"subj":"19176219-15322232-3577029","pred":"source","obj":"2_test"},{"subj":"19176219-15322232-3577029","pred":"source","obj":"2_test"},{"subj":"19176219-15695404-3577029","pred":"source","obj":"2_test"},{"subj":"19176219-15695404-3577029","pred":"source","obj":"2_test"},{"subj":"19176219-16352672-3577029","pred":"source","obj":"2_test"},{"subj":"19176219-16352672-3577029","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecae","default":true}]}]}}