PMC:2678986 / 26140-27671
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2678986","sourcedb":"PMC","sourceid":"2678986","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2678986","text":"The literature concerning OCT expression in the brain is at times contradictory, and this maybe the result of variation between species and also differing area and levels of expression of the transporters within the brain (Sweet et al., 2001). A study by Slitt et al. (2002) found that mRNA for all five organic cation transporters could be detected in the rat brain. Although this work did not evaluate whether the transporters were present at the brain barriers, additional studies have provided some evidence for the presence for individual organic cation transporters at the BBB and choroid plexus. It has been established that OCTN2 is found on the luminal face (and possibly the abluminal face too) of the cerebral capillary endothelial cells of humans, rats, pigs and cows (Kido et al., 2001). OCT2, OCT3, OCTN1 and OCTN2 (but not OCT1) are also expressed in the rat choroid plexus (Sweet et al., 2001). Human OCTs play a crucial role in the initial step involved in hepatic or renal excretion of many cationic compounds. Furthermore, previous studies have demonstrated the involvement of rat OCTs and an undefined organic cation-proton exchanger in the cellular uptake of AZT and 3TC, raising the possibility that human OCTs could also be involved in the uptake of anti-HIV drugs (Minuesa et al., 2008). Moreover, Minuesa et al. (2008) revealed that hOCTs were heterogeneously expressed in primary lymphocytes, monocytes, macrophages and dendritic cells. 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