PMC:2678986 / 22547-23743 JSONTXT

{"project":"2_test","denotations":[{"id":"19176219-14579113-99578334","span":{"begin":141,"end":145},"obj":"14579113"},{"id":"19176219-14579113-99578334","span":{"begin":141,"end":145},"obj":"14579113"},{"id":"19176219-15717059-99578335","span":{"begin":454,"end":458},"obj":"15717059"},{"id":"19176219-15717059-99578335","span":{"begin":454,"end":458},"obj":"15717059"},{"id":"19176219-11905988-99578336","span":{"begin":586,"end":590},"obj":"11905988"},{"id":"19176219-11905988-99578336","span":{"begin":586,"end":590},"obj":"11905988"},{"id":"19176219-10490454-99578337","span":{"begin":796,"end":800},"obj":"10490454"},{"id":"19176219-10490454-99578337","span":{"begin":796,"end":800},"obj":"10490454"},{"id":"19176219-11905988-99578338","span":{"begin":1011,"end":1015},"obj":"11905988"},{"id":"19176219-11905988-99578338","span":{"begin":1011,"end":1015},"obj":"11905988"},{"id":"19176219-14579113-3576970","span":{"begin":141,"end":145},"obj":"14579113"},{"id":"19176219-14579113-3576970","span":{"begin":141,"end":145},"obj":"14579113"},{"id":"19176219-15717059-3576971","span":{"begin":454,"end":458},"obj":"15717059"},{"id":"19176219-15717059-3576971","span":{"begin":454,"end":458},"obj":"15717059"},{"id":"19176219-11905988-3576972","span":{"begin":586,"end":590},"obj":"11905988"},{"id":"19176219-11905988-3576972","span":{"begin":586,"end":590},"obj":"11905988"},{"id":"19176219-10490454-3576973","span":{"begin":796,"end":800},"obj":"10490454"},{"id":"19176219-10490454-3576973","span":{"begin":796,"end":800},"obj":"10490454"}],"text":"All Oatp/OATPS are members of the SLC21 family and 36 Oatps/OATPS have so far been identified in humans, rats and mice (Hagenbuch and Meier, 2004). Several studies have shown that these transporters have a role in the efflux of organic compounds. The expression of OATP1A2 and OATP1C1 have been found in the BBB and the brain, respectively. In rats, Oatp1a4, Oatp1a5 and Oatp1c1 are expressed at the BBB and the blood–CSF barrier (Kusuhara and Sugiyama, 2005). OATP has been implicated in the removal of 2′3′-dideoxycytidine (ddC; zalcitabine) from the brain and CSF (Gibbs and Thomas, 2002). Oatp2 is found at the cerebral capillary endothelium and the choroid plexus epithelium, suggesting a role for these carriers in the transport of drugs between the blood and CNS compartments (Gao et al., 1999). An Oatp-2 like transporter has been implicated in the uptake of the NRTIs, 2′,3′-dideoxyinosine (ddI, didanosine) and (−)-2′-deoxy-3′-thiacytidine (3TC, lamivudine) into the choroid plexus (Gibbs and Thomas, 2002; Gibbs et al., 2003a,b). HIV may enter the CNS via the choroid plexus and therefore transporters present at this site could play an important role in CNS efficacy of certain drugs."}