PMC:2678986 / 17525-18299 JSONTXT

{"project":"2_test","denotations":[{"id":"19176219-16714484-99578305","span":{"begin":201,"end":205},"obj":"16714484"},{"id":"19176219-16714484-99578305","span":{"begin":201,"end":205},"obj":"16714484"},{"id":"19176219-16361063-99578306","span":{"begin":349,"end":353},"obj":"16361063"},{"id":"19176219-16361063-99578306","span":{"begin":349,"end":353},"obj":"16361063"},{"id":"19176219-16714484-99578307","span":{"begin":474,"end":478},"obj":"16714484"},{"id":"19176219-16714484-99578307","span":{"begin":474,"end":478},"obj":"16714484"},{"id":"19176219-16361063-99578308","span":{"begin":502,"end":506},"obj":"16361063"},{"id":"19176219-16361063-99578308","span":{"begin":502,"end":506},"obj":"16361063"},{"id":"19176219-18535159-99578309","span":{"begin":523,"end":527},"obj":"18535159"},{"id":"19176219-18535159-99578309","span":{"begin":523,"end":527},"obj":"18535159"},{"id":"19176219-16361063-99578310","span":{"begin":610,"end":614},"obj":"16361063"},{"id":"19176219-16361063-99578310","span":{"begin":610,"end":614},"obj":"16361063"},{"id":"19176219-18680196-99578311","span":{"begin":768,"end":772},"obj":"18680196"},{"id":"19176219-18680196-99578311","span":{"begin":768,"end":772},"obj":"18680196"},{"id":"19176219-16714484-3576950","span":{"begin":201,"end":205},"obj":"16714484"},{"id":"19176219-16714484-3576950","span":{"begin":201,"end":205},"obj":"16714484"},{"id":"19176219-16361063-3576951","span":{"begin":349,"end":353},"obj":"16361063"},{"id":"19176219-16361063-3576951","span":{"begin":349,"end":353},"obj":"16361063"},{"id":"19176219-16714484-3576952","span":{"begin":523,"end":527},"obj":"16714484"},{"id":"19176219-16714484-3576952","span":{"begin":523,"end":527},"obj":"16714484"},{"id":"19176219-16361063-3576952","span":{"begin":523,"end":527},"obj":"16361063"},{"id":"19176219-16361063-3576952","span":{"begin":523,"end":527},"obj":"16361063"},{"id":"19176219-18535159-3576952","span":{"begin":523,"end":527},"obj":"18535159"},{"id":"19176219-18535159-3576952","span":{"begin":523,"end":527},"obj":"18535159"},{"id":"19176219-16361063-3576953","span":{"begin":610,"end":614},"obj":"16361063"},{"id":"19176219-16361063-3576953","span":{"begin":610,"end":614},"obj":"16361063"},{"id":"19176219-18680196-3576954","span":{"begin":768,"end":772},"obj":"18680196"},{"id":"19176219-18680196-3576954","span":{"begin":768,"end":772},"obj":"18680196"}],"text":"MRPs are ATP-driven efflux transporters. Those localised at the luminal membrane of the brain capillary endothelial cells (i.e. Mrp5) contribute to the non-permissive nature of the BBB (Dallas et al., 2006). However, evidence also exists for an abluminal (Mrp1) and possibly cytoplasmic (Mrp2) expression of specific isoforms (Soontornmalai et al., 2006). Currently, direct evidence exists only for the expression of MRP-1, MRP-2, MRP-4 and MRP-5 at the BBB (Dallas et al., 2006; Soontornmalai et al., 2006; Eilers et al., 2008) and of Mrp1 and Mrp3 (but not Mrp5) at the choroid plexus (Soontornmalai et al., 2006). Interestingly the choroid plexus, but not the BBB, is the main site of blood-facing, Mrp1-dependent cellular efflux from the rat brain (Gazzin et al., 2008)."}