PMC:2678986 / 11362-12297 JSONTXT

{"project":"2_test","denotations":[{"id":"19176219-17709369-99578286","span":{"begin":342,"end":346},"obj":"17709369"},{"id":"19176219-17709369-99578286","span":{"begin":342,"end":346},"obj":"17709369"},{"id":"19176219-18443033-99578287","span":{"begin":361,"end":365},"obj":"18443033"},{"id":"19176219-18443033-99578287","span":{"begin":361,"end":365},"obj":"18443033"},{"id":"19176219-18443033-99578288","span":{"begin":482,"end":486},"obj":"18443033"},{"id":"19176219-18443033-99578288","span":{"begin":482,"end":486},"obj":"18443033"},{"id":"19176219-1977384-99578289","span":{"begin":740,"end":744},"obj":"1977384"},{"id":"19176219-1977384-99578289","span":{"begin":740,"end":744},"obj":"1977384"},{"id":"19176219-1360805-99578290","span":{"begin":929,"end":933},"obj":"1360805"},{"id":"19176219-1360805-99578290","span":{"begin":929,"end":933},"obj":"1360805"},{"id":"19176219-17709369-3576931","span":{"begin":361,"end":365},"obj":"17709369"},{"id":"19176219-17709369-3576931","span":{"begin":361,"end":365},"obj":"17709369"},{"id":"19176219-18443033-3576931","span":{"begin":361,"end":365},"obj":"18443033"},{"id":"19176219-18443033-3576931","span":{"begin":361,"end":365},"obj":"18443033"},{"id":"19176219-18443033-3576932","span":{"begin":482,"end":486},"obj":"18443033"},{"id":"19176219-18443033-3576932","span":{"begin":482,"end":486},"obj":"18443033"},{"id":"19176219-1977384-3576933","span":{"begin":740,"end":744},"obj":"1977384"},{"id":"19176219-1977384-3576933","span":{"begin":740,"end":744},"obj":"1977384"},{"id":"19176219-1360805-3576934","span":{"begin":929,"end":933},"obj":"1360805"},{"id":"19176219-1360805-3576934","span":{"begin":929,"end":933},"obj":"1360805"}],"text":"In comparison to PIs, the interaction of P-gp and NRTIs has been less extensively studied. Recently a study provided in vivo and in vitro evidence that the nucleoside reverse transcriptase inhibitor, abacavir ([(−)-(1S, 4R)-4-[2-amino-6 (cyclopropylamino)-H-purin-9-yl]-2-cyclopentene-1-methanol; 1592U89]) is a P-gp substrate (Shaik et al., 2007; Giri et al., 2008). In fact it is likely that P-gp is the dominant transporter limiting the CNS penetration of abacavir (Giri et al., 2008). Similarly, earlier studies showed that both HIV-infected T cell and monocytic cell lines had increased P-gp expression which accumulated significantly less zidovudine (azidodeoxythymidine (AZT)) in comparison to uninfected cells (Gollapudi and Gupta, 1990). Likewise, a decrease in AZT accumulation in P-gp-over-expressing CEM VBL100 cells with a corresponding decline in antiviral efficacy of the drug has been observed (Antonelli et al., 1992)."}