PMC:2678986 / 10261-11361
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/2678986","sourcedb":"PMC","sourceid":"2678986","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2678986","text":"P-gp, first discovered in 1976, is a 150–180 kDa membrane protein encoded by the multi-drug resistance gene 1 (MDR-1). It is widely expressed in tissues such as the liver, kidney and intestine, as well as the luminal membrane of the BBB (Cordon-Cardo et al., 1989; Jette et al., 1993, 1995; Soontornmalai et al., 2006) and the choroid plexus epithelium (Rao et al., 1999; Gazzin et al., 2008). At the BBB it appears to be important in protecting the brain from hydrophobic molecules and drugs. However, its function at the blood–CSF barrier is ambiguous and it may not have a major neuroprotective role at this site (Gazzin et al., 2008). Uncharged or weakly basic molecules are most efficiently transported by P-gp, but acidic compounds can also be transported. A large body of evidence suggests that PIs are substrates of P-gp and as a result the limited ability of these drugs to transverse the blood–brain barrier is attributed to the activity of this efflux transporter (Kim et al., 1998; Polli et al., 1999; Choo et al., 2000; Park and Sinko, 2005; Bachmeier et al., 2005; Eilers et al., 2008).","tracks":[{"project":"2_test","denotations":[{"id":"19176219-18680196-99578279","span":{"begin":632,"end":636},"obj":"18680196"},{"id":"19176219-18680196-99578279","span":{"begin":632,"end":636},"obj":"18680196"},{"id":"19176219-9435299-99578280","span":{"begin":988,"end":992},"obj":"9435299"},{"id":"19176219-9435299-99578280","span":{"begin":988,"end":992},"obj":"9435299"},{"id":"19176219-10468021-99578281","span":{"begin":1008,"end":1012},"obj":"10468021"},{"id":"19176219-10468021-99578281","span":{"begin":1008,"end":1012},"obj":"10468021"},{"id":"19176219-10820137-99578282","span":{"begin":1027,"end":1031},"obj":"10820137"},{"id":"19176219-10820137-99578282","span":{"begin":1027,"end":1031},"obj":"10820137"},{"id":"19176219-15528451-99578283","span":{"begin":1049,"end":1053},"obj":"15528451"},{"id":"19176219-15528451-99578283","span":{"begin":1049,"end":1053},"obj":"15528451"},{"id":"19176219-16078135-99578284","span":{"begin":1073,"end":1077},"obj":"16078135"},{"id":"19176219-16078135-99578284","span":{"begin":1073,"end":1077},"obj":"16078135"},{"id":"19176219-18535159-99578285","span":{"begin":1094,"end":1098},"obj":"18535159"},{"id":"19176219-18535159-99578285","span":{"begin":1094,"end":1098},"obj":"18535159"},{"id":"19176219-2563168-3576927","span":{"begin":313,"end":317},"obj":"2563168"},{"id":"19176219-2563168-3576927","span":{"begin":313,"end":317},"obj":"2563168"},{"id":"19176219-8102251-3576927","span":{"begin":313,"end":317},"obj":"8102251"},{"id":"19176219-8102251-3576927","span":{"begin":313,"end":317},"obj":"8102251"},{"id":"19176219-7848274-3576927","span":{"begin":313,"end":317},"obj":"7848274"},{"id":"19176219-7848274-3576927","span":{"begin":313,"end":317},"obj":"7848274"},{"id":"19176219-16361063-3576927","span":{"begin":313,"end":317},"obj":"16361063"},{"id":"19176219-16361063-3576927","span":{"begin":313,"end":317},"obj":"16361063"},{"id":"19176219-10097135-3576928","span":{"begin":387,"end":391},"obj":"10097135"},{"id":"19176219-10097135-3576928","span":{"begin":387,"end":391},"obj":"10097135"},{"id":"19176219-18680196-3576928","span":{"begin":387,"end":391},"obj":"18680196"},{"id":"19176219-18680196-3576928","span":{"begin":387,"end":391},"obj":"18680196"},{"id":"19176219-18680196-3576929","span":{"begin":632,"end":636},"obj":"18680196"},{"id":"19176219-18680196-3576929","span":{"begin":632,"end":636},"obj":"18680196"},{"id":"19176219-9435299-3576930","span":{"begin":1094,"end":1098},"obj":"9435299"},{"id":"19176219-9435299-3576930","span":{"begin":1094,"end":1098},"obj":"9435299"},{"id":"19176219-10468021-3576930","span":{"begin":1094,"end":1098},"obj":"10468021"},{"id":"19176219-10468021-3576930","span":{"begin":1094,"end":1098},"obj":"10468021"},{"id":"19176219-10820137-3576930","span":{"begin":1094,"end":1098},"obj":"10820137"},{"id":"19176219-10820137-3576930","span":{"begin":1094,"end":1098},"obj":"10820137"},{"id":"19176219-15528451-3576930","span":{"begin":1094,"end":1098},"obj":"15528451"},{"id":"19176219-15528451-3576930","span":{"begin":1094,"end":1098},"obj":"15528451"},{"id":"19176219-16078135-3576930","span":{"begin":1094,"end":1098},"obj":"16078135"},{"id":"19176219-16078135-3576930","span":{"begin":1094,"end":1098},"obj":"16078135"},{"id":"19176219-18535159-3576930","span":{"begin":1094,"end":1098},"obj":"18535159"},{"id":"19176219-18535159-3576930","span":{"begin":1094,"end":1098},"obj":"18535159"}],"attributes":[{"subj":"19176219-18680196-99578279","pred":"source","obj":"2_test"},{"subj":"19176219-18680196-99578279","pred":"source","obj":"2_test"},{"subj":"19176219-9435299-99578280","pred":"source","obj":"2_test"},{"subj":"19176219-9435299-99578280","pred":"source","obj":"2_test"},{"subj":"19176219-10468021-99578281","pred":"source","obj":"2_test"},{"subj":"19176219-10468021-99578281","pred":"source","obj":"2_test"},{"subj":"19176219-10820137-99578282","pred":"source","obj":"2_test"},{"subj":"19176219-10820137-99578282","pred":"source","obj":"2_test"},{"subj":"19176219-15528451-99578283","pred":"source","obj":"2_test"},{"subj":"19176219-15528451-99578283","pred":"source","obj":"2_test"},{"subj":"19176219-16078135-99578284","pred":"source","obj":"2_test"},{"subj":"19176219-16078135-99578284","pred":"source","obj":"2_test"},{"subj":"19176219-18535159-99578285","pred":"source","obj":"2_test"},{"subj":"19176219-18535159-99578285","pred":"source","obj":"2_test"},{"subj":"19176219-2563168-3576927","pred":"source","obj":"2_test"},{"subj":"19176219-2563168-3576927","pred":"source","obj":"2_test"},{"subj":"19176219-8102251-3576927","pred":"source","obj":"2_test"},{"subj":"19176219-8102251-3576927","pred":"source","obj":"2_test"},{"subj":"19176219-7848274-3576927","pred":"source","obj":"2_test"},{"subj":"19176219-7848274-3576927","pred":"source","obj":"2_test"},{"subj":"19176219-16361063-3576927","pred":"source","obj":"2_test"},{"subj":"19176219-16361063-3576927","pred":"source","obj":"2_test"},{"subj":"19176219-10097135-3576928","pred":"source","obj":"2_test"},{"su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