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{"project":"GO-MF","denotations":[{"id":"T773","span":{"begin":357,"end":363},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T774","span":{"begin":520,"end":544},"obj":"http://purl.obolibrary.org/obo/GO_0030295"},{"id":"T775","span":{"begin":546,"end":550},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T776","span":{"begin":603,"end":606},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T777","span":{"begin":552,"end":563},"obj":"http://purl.obolibrary.org/obo/GO_0016791"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}

{"project":"GO-CC","denotations":[{"id":"T779","span":{"begin":91,"end":96},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}

{"project":"sentences","denotations":[{"id":"T140","span":{"begin":0,"end":20},"obj":"Sentence"},{"id":"T141","span":{"begin":21,"end":460},"obj":"Sentence"},{"id":"T142","span":{"begin":461,"end":665},"obj":"Sentence"},{"id":"T143","span":{"begin":666,"end":739},"obj":"Sentence"},{"id":"T144","span":{"begin":740,"end":888},"obj":"Sentence"},{"id":"T10","span":{"begin":0,"end":20},"obj":"Sentence"},{"id":"T11","span":{"begin":21,"end":460},"obj":"Sentence"},{"id":"T12","span":{"begin":461,"end":665},"obj":"Sentence"},{"id":"T13","span":{"begin":666,"end":739},"obj":"Sentence"},{"id":"T14","span":{"begin":740,"end":888},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}

{"project":"ICD10","denotations":[{"id":"T780","span":{"begin":873,"end":879},"obj":"http://purl.bioontology.org/ontology/ICD10/J45"},{"id":"T769","span":{"begin":873,"end":879},"obj":"http://purl.bioontology.org/ontology/ICD10/J45.9"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}

{"project":"events-check-again","denotations":[{"id":"T893","span":{"begin":176,"end":184},"obj":"Negative_regulation"},{"id":"T894","span":{"begin":185,"end":192},"obj":"Entity"},{"id":"T895","span":{"begin":193,"end":206},"obj":"Localization"},{"id":"T896","span":{"begin":210,"end":216},"obj":"Protein"},{"id":"T897","span":{"begin":322,"end":333},"obj":"Negative_regulation"},{"id":"T898","span":{"begin":322,"end":333},"obj":"Negative_regulation"},{"id":"T899","span":{"begin":342,"end":348},"obj":"Protein"},{"id":"T900","span":{"begin":364,"end":373},"obj":"Positive_regulation"},{"id":"T901","span":{"begin":374,"end":397},"obj":"Protein"},{"id":"T902","span":{"begin":402,"end":409},"obj":"Entity"},{"id":"T903","span":{"begin":410,"end":419},"obj":"Localization"},{"id":"T904","span":{"begin":410,"end":419},"obj":"Localization"},{"id":"T905","span":{"begin":486,"end":493},"obj":"Positive_regulation"},{"id":"T906","span":{"begin":498,"end":508},"obj":"Gene_expression"},{"id":"T907","span":{"begin":512,"end":565},"obj":"Protein"},{"id":"T908","span":{"begin":567,"end":572},"obj":"Protein"},{"id":"T909","span":{"begin":622,"end":631},"obj":"Positive_regulation"},{"id":"T910","span":{"begin":636,"end":642},"obj":"Protein"},{"id":"T911","span":{"begin":643,"end":650},"obj":"Entity"},{"id":"T912","span":{"begin":651,"end":664},"obj":"Localization"},{"id":"T913","span":{"begin":786,"end":794},"obj":"Negative_regulation"},{"id":"T914","span":{"begin":795,"end":801},"obj":"Protein"},{"id":"T915","span":{"begin":802,"end":809},"obj":"Entity"},{"id":"T916","span":{"begin":810,"end":823},"obj":"Localization"}],"relations":[{"id":"R695","pred":"locationOf","subj":"T894","obj":"T895"},{"id":"R696","pred":"themeOf","subj":"T895","obj":"T893"},{"id":"R697","pred":"themeOf","subj":"T896","obj":"T895"},{"id":"R704","pred":"themeOf","subj":"T899","obj":"T904"},{"id":"R707","pred":"themeOf","subj":"T901","obj":"T903"},{"id":"R708","pred":"themeOf","subj":"T901","obj":"T900"},{"id":"R709","pred":"locationOf","subj":"T902","obj":"T904"},{"id":"R710","pred":"locationOf","subj":"T902","obj":"T903"},{"id":"R712","pred":"themeOf","subj":"T903","obj":"T897"},{"id":"R714","pred":"themeOf","subj":"T904","obj":"T898"},{"id":"R715","pred":"themeOf","subj":"T906","obj":"T905"},{"id":"R716","pred":"themeOf","subj":"T907","obj":"T906"},{"id":"R717","pred":"equivalentTo","subj":"T908","obj":"T907"},{"id":"R718","pred":"themeOf","subj":"T910","obj":"T912"},{"id":"R720","pred":"locationOf","subj":"T911","obj":"T912"},{"id":"R722","pred":"themeOf","subj":"T912","obj":"T909"},{"id":"R723","pred":"themeOf","subj":"T914","obj":"T916"},{"id":"R724","pred":"locationOf","subj":"T915","obj":"T916"},{"id":"R725","pred":"themeOf","subj":"T916","obj":"T913"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T932","span":{"begin":111,"end":119},"obj":"Protein"},{"id":"T933","span":{"begin":124,"end":133},"obj":"Protein"},{"id":"T934","span":{"begin":210,"end":216},"obj":"Protein"},{"id":"T935","span":{"begin":280,"end":297},"obj":"Protein"},{"id":"T936","span":{"begin":342,"end":348},"obj":"Protein"},{"id":"T937","span":{"begin":374,"end":397},"obj":"Protein"},{"id":"T938","span":{"begin":185,"end":192},"obj":"Entity"},{"id":"T939","span":{"begin":193,"end":206},"obj":"Localization"},{"id":"T940","span":{"begin":357,"end":373},"obj":"Positive_regulation"},{"id":"T941","span":{"begin":176,"end":184},"obj":"Negative_regulation"},{"id":"T942","span":{"begin":512,"end":544},"obj":"Protein"},{"id":"T943","span":{"begin":546,"end":550},"obj":"Protein"},{"id":"T944","span":{"begin":603,"end":611},"obj":"Protein"},{"id":"T945","span":{"begin":498,"end":508},"obj":"Gene_expression"},{"id":"T946","span":{"begin":498,"end":508},"obj":"Gene_expression"},{"id":"T947","span":{"begin":590,"end":599},"obj":"Negative_regulation"},{"id":"T948","span":{"begin":651,"end":664},"obj":"Localization"},{"id":"T949","span":{"begin":486,"end":493},"obj":"Positive_regulation"},{"id":"T950","span":{"begin":486,"end":493},"obj":"Positive_regulation"},{"id":"T951","span":{"begin":622,"end":631},"obj":"Positive_regulation"}],"relations":[{"id":"R752","pred":"themeOf","subj":"T942","obj":"T945"},{"id":"R754","pred":"themeOf","subj":"T943","obj":"T946"},{"id":"R755","pred":"themeOf","subj":"T943","obj":"T948"},{"id":"R756","pred":"themeOf","subj":"T944","obj":"T947"},{"id":"R758","pred":"themeOf","subj":"T945","obj":"T949"},{"id":"R759","pred":"themeOf","subj":"T946","obj":"T950"},{"id":"R761","pred":"themeOf","subj":"T948","obj":"T951"},{"id":"R746","pred":"themeOf","subj":"T934","obj":"T939"},{"id":"R747","pred":"themeOf","subj":"T937","obj":"T940"},{"id":"R748","pred":"locationOf","subj":"T938","obj":"T939"},{"id":"R750","pred":"themeOf","subj":"T939","obj":"T941"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T109","span":{"begin":176,"end":184},"obj":"Negative_regulation"},{"id":"T110","span":{"begin":185,"end":192},"obj":"Entity"},{"id":"T111","span":{"begin":193,"end":206},"obj":"Localization"},{"id":"T112","span":{"begin":210,"end":216},"obj":"Protein"},{"id":"T113","span":{"begin":322,"end":333},"obj":"Negative_regulation"},{"id":"T114","span":{"begin":322,"end":333},"obj":"Negative_regulation"},{"id":"T115","span":{"begin":342,"end":348},"obj":"Protein"},{"id":"T116","span":{"begin":364,"end":373},"obj":"Positive_regulation"},{"id":"T117","span":{"begin":374,"end":397},"obj":"Protein"},{"id":"T118","span":{"begin":402,"end":409},"obj":"Entity"},{"id":"T119","span":{"begin":410,"end":419},"obj":"Localization"},{"id":"T120","span":{"begin":410,"end":419},"obj":"Localization"},{"id":"T121","span":{"begin":486,"end":493},"obj":"Positive_regulation"},{"id":"T122","span":{"begin":498,"end":508},"obj":"Gene_expression"},{"id":"T123","span":{"begin":512,"end":565},"obj":"Protein"},{"id":"T124","span":{"begin":567,"end":572},"obj":"Protein"},{"id":"T125","span":{"begin":622,"end":631},"obj":"Positive_regulation"},{"id":"T126","span":{"begin":636,"end":642},"obj":"Protein"},{"id":"T127","span":{"begin":643,"end":650},"obj":"Entity"},{"id":"T128","span":{"begin":651,"end":664},"obj":"Localization"},{"id":"T129","span":{"begin":786,"end":794},"obj":"Negative_regulation"},{"id":"T130","span":{"begin":795,"end":801},"obj":"Protein"},{"id":"T131","span":{"begin":802,"end":809},"obj":"Entity"},{"id":"T132","span":{"begin":810,"end":823},"obj":"Localization"}],"relations":[{"id":"R79","pred":"locationOf","subj":"T110","obj":"T111"},{"id":"R80","pred":"themeOf","subj":"T111","obj":"T109"},{"id":"R81","pred":"themeOf","subj":"T112","obj":"T111"},{"id":"R82","pred":"themeOf","subj":"T115","obj":"T120"},{"id":"R83","pred":"themeOf","subj":"T117","obj":"T119"},{"id":"R84","pred":"themeOf","subj":"T117","obj":"T116"},{"id":"R85","pred":"locationOf","subj":"T118","obj":"T120"},{"id":"R86","pred":"locationOf","subj":"T118","obj":"T119"},{"id":"R87","pred":"themeOf","subj":"T119","obj":"T113"},{"id":"R88","pred":"themeOf","subj":"T120","obj":"T114"},{"id":"R89","pred":"themeOf","subj":"T122","obj":"T121"},{"id":"R90","pred":"themeOf","subj":"T123","obj":"T122"},{"id":"R91","pred":"equivalentTo","subj":"T124","obj":"T123"},{"id":"R92","pred":"themeOf","subj":"T126","obj":"T128"},{"id":"R93","pred":"locationOf","subj":"T127","obj":"T128"},{"id":"R94","pred":"themeOf","subj":"T128","obj":"T125"},{"id":"R95","pred":"themeOf","subj":"T130","obj":"T132"},{"id":"R96","pred":"locationOf","subj":"T131","obj":"T132"},{"id":"R97","pred":"themeOf","subj":"T132","obj":"T129"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T436","span":{"begin":116,"end":119},"obj":"P04234"},{"id":"T437","span":{"begin":116,"end":119},"obj":"P20963"},{"id":"T438","span":{"begin":116,"end":119},"obj":"P09693"},{"id":"T439","span":{"begin":116,"end":119},"obj":"P07766"},{"id":"T440","span":{"begin":129,"end":133},"obj":"P10747"},{"id":"T441","span":{"begin":210,"end":216},"obj":"P23771"},{"id":"T442","span":{"begin":342,"end":348},"obj":"P23771"},{"id":"T443","span":{"begin":374,"end":397},"obj":"P04150"},{"id":"T444","span":{"begin":512,"end":544},"obj":"P27361"},{"id":"T445","span":{"begin":512,"end":544},"obj":"P28482"},{"id":"T446","span":{"begin":567,"end":572},"obj":"P28562"},{"id":"T447","span":{"begin":603,"end":606},"obj":"P53778"},{"id":"T448","span":{"begin":603,"end":606},"obj":"Q16539"},{"id":"T449","span":{"begin":603,"end":606},"obj":"Q15759"},{"id":"T450","span":{"begin":603,"end":606},"obj":"O15264"},{"id":"T451","span":{"begin":636,"end":642},"obj":"P23771"},{"id":"T452","span":{"begin":795,"end":801},"obj":"P23771"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}

{"project":"test2","denotations":[{"id":"T63","span":{"begin":176,"end":184},"obj":"Negative_regulation"},{"id":"T64","span":{"begin":185,"end":192},"obj":"Entity"},{"id":"T65","span":{"begin":193,"end":206},"obj":"Localization"},{"id":"T66","span":{"begin":210,"end":216},"obj":"Protein"},{"id":"T67","span":{"begin":221,"end":231},"obj":"Gene_expression"},{"id":"T68","span":{"begin":265,"end":276},"obj":"Regulation"},{"id":"T69","span":{"begin":322,"end":333},"obj":"Negative_regulation"},{"id":"T70","span":{"begin":342,"end":348},"obj":"Protein"},{"id":"T71","span":{"begin":364,"end":373},"obj":"Positive_regulation"},{"id":"T72","span":{"begin":374,"end":397},"obj":"Protein"},{"id":"T73","span":{"begin":486,"end":493},"obj":"Positive_regulation"},{"id":"T74","span":{"begin":498,"end":508},"obj":"Gene_expression"},{"id":"T75","span":{"begin":512,"end":565},"obj":"Protein"},{"id":"T76","span":{"begin":567,"end":572},"obj":"Protein"},{"id":"T77","span":{"begin":622,"end":631},"obj":"Positive_regulation"},{"id":"T78","span":{"begin":636,"end":642},"obj":"Protein"},{"id":"T79","span":{"begin":643,"end":650},"obj":"Entity"},{"id":"T80","span":{"begin":651,"end":664},"obj":"Localization"},{"id":"T81","span":{"begin":786,"end":794},"obj":"Negative_regulation"},{"id":"T82","span":{"begin":795,"end":801},"obj":"Protein"},{"id":"T83","span":{"begin":802,"end":809},"obj":"Entity"},{"id":"T84","span":{"begin":810,"end":823},"obj":"Localization"}],"relations":[{"id":"R59","pred":"themeOf","subj":"T72","obj":"T71"},{"id":"R60","pred":"themeOf","subj":"T74","obj":"T73"},{"id":"R61","pred":"causeOf","subj":"T74","obj":"T77"},{"id":"R62","pred":"themeOf","subj":"T75","obj":"T74"},{"id":"R63","pred":"equivalentTo","subj":"T76","obj":"T75"},{"id":"R64","pred":"themeOf","subj":"T78","obj":"T80"},{"id":"R65","pred":"locationOf","subj":"T79","obj":"T80"},{"id":"R66","pred":"themeOf","subj":"T80","obj":"T77"},{"id":"R67","pred":"themeOf","subj":"T82","obj":"T84"},{"id":"R68","pred":"locationOf","subj":"T83","obj":"T84"},{"id":"R69","pred":"themeOf","subj":"T84","obj":"T81"},{"id":"R50","pred":"themeOf","subj":"T63","obj":"T68"},{"id":"R51","pred":"locationOf","subj":"T64","obj":"T65"},{"id":"R52","pred":"themeOf","subj":"T65","obj":"T68"},{"id":"R53","pred":"themeOf","subj":"T65","obj":"T63"},{"id":"R54","pred":"themeOf","subj":"T66","obj":"T67"},{"id":"R55","pred":"themeOf","subj":"T67","obj":"T63"},{"id":"R56","pred":"themeOf","subj":"T67","obj":"T68"},{"id":"R57","pred":"themeOf","subj":"T70","obj":"T71"},{"id":"R58","pred":"themeOf","subj":"T70","obj":"T69"}],"text":"Methods and Findings\nIn a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α. In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation. These inhibitory effects of fluticasone are rapid, potent, and prolonged. We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo."}