PMC:2674207 / 8358-9202 JSONTXT

{"project":"2_test","denotations":[{"id":"19436703-17277157-86274458","span":{"begin":87,"end":89},"obj":"17277157"},{"id":"19436703-11751746-86274459","span":{"begin":342,"end":344},"obj":"11751746"},{"id":"19436703-17277157-86274460","span":{"begin":445,"end":447},"obj":"17277157"},{"id":"19436703-8114750-86274461","span":{"begin":501,"end":503},"obj":"8114750"},{"id":"19436703-17277157-86274462","span":{"begin":613,"end":615},"obj":"17277157"},{"id":"19436703-17277157-86274463","span":{"begin":767,"end":769},"obj":"17277157"},{"id":"19436703-8114750-86274464","span":{"begin":772,"end":774},"obj":"8114750"},{"id":"T49366","span":{"begin":87,"end":89},"obj":"17277157"},{"id":"T50729","span":{"begin":342,"end":344},"obj":"11751746"},{"id":"T71477","span":{"begin":445,"end":447},"obj":"17277157"},{"id":"T49898","span":{"begin":501,"end":503},"obj":"8114750"},{"id":"T29972","span":{"begin":613,"end":615},"obj":"17277157"},{"id":"T24249","span":{"begin":767,"end":769},"obj":"17277157"},{"id":"T62255","span":{"begin":772,"end":774},"obj":"8114750"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"pmc-enju-pas","denotations":[{"id":"T1526","span":{"begin":3,"end":5},"obj":"IN"},{"id":"T1527","span":{"begin":6,"end":11},"obj":"JJ"},{"id":"T1528","span":{"begin":12,"end":13},"obj":"NN"},{"id":"T1529","span":{"begin":14,"end":19},"obj":"NN"},{"id":"T1530","span":{"begin":20,"end":27},"obj":"VB"},{"id":"T1531","span":{"begin":28,"end":30},"obj":"IN"},{"id":"T1532","span":{"begin":31,"end":35},"obj":"NN"},{"id":"T1533","span":{"begin":36,"end":38},"obj":"IN"},{"id":"T1534","span":{"begin":39,"end":61},"obj":"JJ"},{"id":"T1535","span":{"begin":62,"end":65},"obj":"NN"},{"id":"T1536","span":{"begin":66,"end":74},"obj":"NN"},{"id":"T1537","span":{"begin":75,"end":85},"obj":"NN"},{"id":"T1538","span":{"begin":86,"end":87},"obj":"-LRB-"},{"id":"T1539","span":{"begin":87,"end":89},"obj":"CD"},{"id":"T1540","span":{"begin":89,"end":90},"obj":"-RRB-"},{"id":"T1541","span":{"begin":92,"end":94},"obj":"IN"},{"id":"T1542","span":{"begin":95,"end":100},"obj":"NN"},{"id":"T1543","span":{"begin":101,"end":104},"obj":"IN"},{"id":"T1544","span":{"begin":105,"end":111},"obj":"NN"},{"id":"T1545","span":{"begin":112,"end":114},"obj":"TO"},{"id":"T1546","span":{"begin":115,"end":123},"obj":"VB"},{"id":"T1547","span":{"begin":124,"end":128},"obj":"NN"},{"id":"T1548","span":{"begin":129,"end":139},"obj":"NN"},{"id":"T1549","span":{"begin":139,"end":140},"obj":"-COMMA-"},{"id":"T1550","span":{"begin":141,"end":143},"obj":"PRP"},{"id":"T1551","span":{"begin":144,"end":148},"obj":"MD"},{"id":"T1552","span":{"begin":149,"end":160},"obj":"VB"},{"id":"T1553","span":{"begin":161,"end":165},"obj":"IN"},{"id":"T1554","span":{"begin":166,"end":169},"obj":"DT"},{"id":"T1555","span":{"begin":170,"end":179},"obj":"NN"},{"id":"T1556","span":{"begin":180,"end":184},"obj":"IN"},{"id":"T1557","span":{"begin":185,"end":188},"obj":"DT"},{"id":"T1558","span":{"begin":189,"end":196},"obj":"NN"},{"id":"T1559","span":{"begin":197,"end":199},"obj":"TO"},{"id":"T1560","span":{"begin":200,"end":206},"obj":"VB"},{"id":"T1561","span":{"begin":207,"end":210},"obj":"PRP-DOLLAR-"},{"id":"T1562","span":{"begin":211,"end":217},"obj":"NN"},{"id":"T1563","span":{"begin":218,"end":223},"obj":"NN"},{"id":"T1564","span":{"begin":225,"end":233},"obj":"VB"},{"id":"T1565","span":{"begin":234,"end":241},"obj":"JJ"},{"id":"T1566","span":{"begin":242,"end":252},"obj":"NN"},{"id":"T1567","span":{"begin":253,"end":255},"obj":"IN"},{"id":"T1568","span":{"begin":256,"end":262},"obj":"NN"},{"id":"T1569","span":{"begin":263,"end":272},"obj":"VB"},{"id":"T1570","span":{"begin":273,"end":274},"obj":"NN"},{"id":"T1571","span":{"begin":275,"end":279},"obj":"NN"},{"id":"T1572","span":{"begin":280,"end":288},"obj":"NN"},{"id":"T1573","span":{"begin":289,"end":299},"obj":"NN"},{"id":"T1574","span":{"begin":300,"end":303},"obj":"VB"},{"id":"T1575","span":{"begin":304,"end":309},"obj":"RB"},{"id":"T1576","span":{"begin":310,"end":322},"obj":"VB"},{"id":"T1577","span":{"begin":323,"end":325},"obj":"IN"},{"id":"T1578","span":{"begin":326,"end":332},"obj":"JJ"},{"id":"T1579","span":{"begin":333,"end":334},"obj":"NN"},{"id":"T1580","span":{"begin":335,"end":340},"obj":"NN"},{"id":"T1581","span":{"begin":341,"end":342},"obj":"-LRB-"},{"id":"T1582","span":{"begin":342,"end":344},"obj":"CD"},{"id":"T1583","span":{"begin":344,"end":345},"obj":"-RRB-"},{"id":"T1584","span":{"begin":346,"end":349},"obj":"CC"},{"id":"T1585","span":{"begin":350,"end":353},"obj":"VB"},{"id":"T1586","span":{"begin":354,"end":362},"obj":"RB"},{"id":"T1587","span":{"begin":363,"end":372},"obj":"VB"},{"id":"T1588","span":{"begin":373,"end":375},"obj":"IN"},{"id":"T1589","span":{"begin":376,"end":381},"obj":"JJ"},{"id":"T1590","span":{"begin":382,"end":383},"obj":"NN"},{"id":"T1591","span":{"begin":384,"end":389},"obj":"NN"},{"id":"T1592","span":{"begin":390,"end":399},"obj":"VB"},{"id":"T1593","span":{"begin":400,"end":401},"obj":"NN"},{"id":"T1594","span":{"begin":402,"end":406},"obj":"NN"},{"id":"T1595","span":{"begin":407,"end":415},"obj":"NN"},{"id":"T1596","span":{"begin":416,"end":419},"obj":"CC"},{"id":"T1597","span":{"begin":420,"end":431},"obj":"NN"},{"id":"T1598","span":{"begin":432,"end":443},"obj":"NN"},{"id":"T1599","span":{"begin":444,"end":445},"obj":"-LRB-"},{"id":"T1600","span":{"begin":445,"end":447},"obj":"CD"},{"id":"T1601","span":{"begin":447,"end":448},"obj":"-RRB-"},{"id":"T1602","span":{"begin":450,"end":456},"obj":"NN"},{"id":"T1603","span":{"begin":457,"end":465},"obj":"VB"},{"id":"T1604","span":{"begin":466,"end":467},"obj":"DT"},{"id":"T1605","span":{"begin":468,"end":477},"obj":"JJ"},{"id":"T1606","span":{"begin":478,"end":485},"obj":"JJ"},{"id":"T1607","span":{"begin":486,"end":492},"obj":"NN"},{"id":"T1608","span":{"begin":493,"end":499},"obj":"NN"},{"id":"T1609","span":{"begin":500,"end":501},"obj":"-LRB-"},{"id":"T1610","span":{"begin":501,"end":503},"obj":"CD"},{"id":"T1611","span":{"begin":503,"end":504},"obj":"-RRB-"},{"id":"T1612","span":{"begin":505,"end":508},"obj":"CC"},{"id":"T1613","span":{"begin":509,"end":511},"obj":"VB"},{"id":"T1614","span":{"begin":512,"end":523},"obj":"VB"},{"id":"T1615","span":{"begin":524,"end":528},"obj":"IN"},{"id":"T1616","span":{"begin":529,"end":532},"obj":"DT"},{"id":"T1617","span":{"begin":533,"end":540},"obj":"NN"},{"id":"T1618","span":{"begin":541,"end":543},"obj":"IN"},{"id":"T1619","span":{"begin":544,"end":547},"obj":"DT"},{"id":"T1620","span":{"begin":548,"end":555},"obj":"JJ"},{"id":"T1621","span":{"begin":556,"end":562},"obj":"NN"},{"id":"T1622","span":{"begin":563,"end":570},"obj":"NN"},{"id":"T1623","span":{"begin":571,"end":581},"obj":"NN"},{"id":"T1624","span":{"begin":582,"end":583},"obj":"-LRB-"},{"id":"T1625","span":{"begin":583,"end":587},"obj":"RB"},{"id":"T1626","span":{"begin":588,"end":593},"obj":"VB"},{"id":"T1627","span":{"begin":594,"end":596},"obj":"IN"},{"id":"T1628","span":{"begin":597,"end":610},"obj":"NN"},{"id":"T1629","span":{"begin":610,"end":611},"obj":"-RRB-"},{"id":"T1630","span":{"begin":612,"end":613},"obj":"-LRB-"},{"id":"T1631","span":{"begin":613,"end":615},"obj":"CD"},{"id":"T1632","span":{"begin":615,"end":616},"obj":"-RRB-"},{"id":"T1633","span":{"begin":618,"end":626},"obj":"NN"},{"id":"T1634","span":{"begin":627,"end":629},"obj":"IN"},{"id":"T1635","span":{"begin":630,"end":631},"obj":"DT"},{"id":"T1636","span":{"begin":632,"end":638},"obj":"NN"},{"id":"T1637","span":{"begin":639,"end":651},"obj":"VB"},{"id":"T1638","span":{"begin":652,"end":655},"obj":"DT"},{"id":"T1639","span":{"begin":656,"end":662},"obj":"NN"},{"id":"T1640","span":{"begin":663,"end":670},"obj":"JJ"},{"id":"T1641","span":{"begin":671,"end":683},"obj":"NN"},{"id":"T1642","span":{"begin":684,"end":692},"obj":"NN"},{"id":"T1643","span":{"begin":693,"end":694},"obj":"-LRB-"},{"id":"T1644","span":{"begin":694,"end":697},"obj":"NN"},{"id":"T1645","span":{"begin":697,"end":698},"obj":"-RRB-"},{"id":"T1646","span":{"begin":699,"end":705},"obj":"NN"},{"id":"T1647","span":{"begin":706,"end":708},"obj":"IN"},{"id":"T1648","span":{"begin":709,"end":715},"obj":"JJ"},{"id":"T1649","span":{"begin":716,"end":719},"obj":"CC"},{"id":"T1650","span":{"begin":720,"end":725},"obj":"JJ"},{"id":"T1651","span":{"begin":726,"end":731},"obj":"NN"},{"id":"T1652","span":{"begin":732,"end":740},"obj":"VB"},{"id":"T1653","span":{"begin":741,"end":744},"obj":"PRP-DOLLAR-"},{"id":"T1654","span":{"begin":745,"end":752},"obj":"JJ"},{"id":"T1655","span":{"begin":753,"end":765},"obj":"NN"},{"id":"T1656","span":{"begin":766,"end":767},"obj":"-LRB-"},{"id":"T1657","span":{"begin":767,"end":769},"obj":"CD"},{"id":"T1658","span":{"begin":769,"end":770},"obj":"-RRB-"},{"id":"T1659","span":{"begin":770,"end":771},"obj":"-COMMA-"},{"id":"T1660","span":{"begin":771,"end":772},"obj":"-LRB-"},{"id":"T1661","span":{"begin":772,"end":774},"obj":"CD"},{"id":"T1662","span":{"begin":774,"end":775},"obj":"-RRB-"},{"id":"T1663","span":{"begin":777,"end":780},"obj":"DT"},{"id":"T1664","span":{"begin":781,"end":789},"obj":"NN"},{"id":"T1665","span":{"begin":790,"end":792},"obj":"IN"},{"id":"T1666","span":{"begin":793,"end":796},"obj":"DT"},{"id":"T1667","span":{"begin":797,"end":811},"obj":"JJ"},{"id":"T1668","span":{"begin":812,"end":823},"obj":"NN"},{"id":"T1669","span":{"begin":824,"end":826},"obj":"VB"},{"id":"T1670","span":{"begin":827,"end":836},"obj":"VB"},{"id":"T1671","span":{"begin":837,"end":839},"obj":"IN"}],"relations":[{"id":"R1254","pred":"arg2Of","subj":"T1529","obj":"T1526"},{"id":"R1255","pred":"arg1Of","subj":"T1529","obj":"T1527"},{"id":"R1256","pred":"arg1Of","subj":"T1529","obj":"T1528"},{"id":"R1259","pred":"arg1Of","subj":"T1530","obj":"T1531"},{"id":"R1260","pred":"arg1Of","subj":"T1530","obj":"T1538"},{"id":"R1261","pred":"arg2Of","subj":"T1532","obj":"T1531"},{"id":"R1262","pred":"arg1Of","subj":"T1532","obj":"T1533"},{"id":"R1263","pred":"arg2Of","subj":"T1537","obj":"T1533"},{"id":"R1264","pred":"arg1Of","subj":"T1537","obj":"T1534"},{"id":"R1265","pred":"arg1Of","subj":"T1537","obj":"T1535"},{"id":"R1266","pred":"arg1Of","subj":"T1537","obj":"T1536"},{"id":"R1267","pred":"arg2Of","subj":"T1539","obj":"T1538"},{"id":"R1268","pred":"arg3Of","subj":"T1540","obj":"T1538"},{"id":"R1269","pred":"arg2Of","subj":"T1542","obj":"T1541"},{"id":"R1270","pred":"arg1Of","subj":"T1542","obj":"T1543"},{"id":"R1271","pred":"arg2Of","subj":"T1544","obj":"T1543"},{"id":"R1272","pred":"arg1Of","subj":"T1544","obj":"T1546"},{"id":"R1273","pred":"arg3Of","subj":"T1546","obj":"T1543"},{"id":"R1274","pred":"arg1Of","subj":"T1546","obj":"T1545"},{"id":"R1275","pred":"arg2Of","subj":"T1548","obj":"T1546"},{"id":"R1276","pred":"arg1Of","subj":"T1548","obj":"T1547"},{"id":"R1277","pred":"arg1Of","subj":"T1550","obj":"T1551"},{"id":"R1278","pred":"arg1Of","subj":"T1550","obj":"T1552"},{"id":"R1279","pred":"arg1Of","subj":"T1552","obj":"T1541"},{"id":"R1280","pred":"arg1Of","subj":"T1552","obj":"T1549"},{"id":"R1281","pred":"arg2Of","subj":"T1552","obj":"T1551"},{"id":"R1282","pred":"arg1Of","subj":"T1552","obj":"T1553"},{"id":"R1283","pred":"arg2Of","subj":"T1555","obj":"T1553"},{"id":"R1284","pred":"arg1Of","subj":"T1555","obj":"T1554"},{"id":"R1285","pred":"arg1Of","subj":"T1555","obj":"T1556"},{"id":"R1286","pred":"arg2Of","subj":"T1558","obj":"T1556"},{"id":"R1287","pred":"arg1Of","subj":"T1558","obj":"T1557"},{"id":"R1288","pred":"modOf","subj":"T1558","obj":"T1559"},{"id":"R1289","pred":"arg1Of","subj":"T1560","obj":"T1559"},{"id":"R1290","pred":"arg2Of","subj":"T1563","obj":"T1560"},{"id":"R1291","pred":"arg1Of","subj":"T1563","obj":"T1561"},{"id":"R1292","pred":"arg1Of","subj":"T1563","obj":"T1562"},{"id":"R1293","pred":"arg2Of","subj":"T1566","obj":"T1564"},{"id":"R1294","pred":"arg1Of","subj":"T1566","obj":"T1565"},{"id":"R1295","pred":"arg1Of","subj":"T1566","obj":"T1567"},{"id":"R1296","pred":"arg1Of","subj":"T1566","obj":"T1574"},{"id":"R1297","pred":"arg2Of","subj":"T1566","obj":"T1576"},{"id":"R1298","pred":"arg1Of","subj":"T1566","obj":"T1585"},{"id":"R1299","pred":"arg2Of","subj":"T1566","obj":"T1587"},{"id":"R1300","pred":"arg2Of","subj":"T1568","obj":"T1567"},{"id":"R1301","pred":"arg1Of","subj":"T1568","obj":"T1569"},{"id":"R1302","pred":"arg2Of","subj":"T1573","obj":"T1569"},{"id":"R1303","pred":"arg1Of","subj":"T1573","obj":"T1570"},{"id":"R1304","pred":"arg1Of","subj":"T1573","obj":"T1571"},{"id":"R1305","pred":"arg1Of","subj":"T1573","obj":"T1572"},{"id":"R1306","pred":"arg2Of","subj":"T1576","obj":"T1574"},{"id":"R1307","pred":"arg1Of","subj":"T1576","obj":"T1575"},{"id":"R1308","pred":"arg1Of","subj":"T1576","obj":"T1577"},{"id":"R1309","pred":"arg1Of","subj":"T1576","obj":"T1581"},{"id":"R1310","pred":"arg1Of","subj":"T1576","obj":"T1584"},{"id":"R1311","pred":"arg2Of","subj":"T1580","obj":"T1577"},{"id":"R1312","pred":"arg1Of","subj":"T1580","obj":"T1578"},{"id":"R1313","pred":"arg1Of","subj":"T1580","obj":"T1579"},{"id":"R1314","pred":"arg2Of","subj":"T1582","obj":"T1581"},{"id":"R1315","pred":"arg3Of","subj":"T1583","obj":"T1581"},{"id":"R1316","pred":"arg2Of","subj":"T1587","obj":"T1584"},{"id":"R1317","pred":"arg2Of","subj":"T1587","obj":"T1585"},{"id":"R1318","pred":"arg1Of","subj":"T1587","obj":"T1586"},{"id":"R1319","pred":"arg1Of","subj":"T1587","obj":"T1588"},{"id":"R1320","pred":"arg1Of","subj":"T1587","obj":"T1592"},{"id":"R1321","pred":"arg2Of","subj":"T1591","obj":"T1588"},{"id":"R1322","pred":"arg1Of","subj":"T1591","obj":"T1589"},{"id":"R1323","pred":"arg1Of","subj":"T1591","obj":"T1590"},{"id":"R1324","pred":"arg1Of","subj":"T1595","obj":"T1593"},{"id":"R1325","pred":"arg1Of","subj":"T1595","obj":"T1594"},{"id":"R1326","pred":"arg1Of","subj":"T1595","obj":"T1596"},{"id":"R1327","pred":"arg2Of","subj":"T1596","obj":"T1592"},{"id":"R1328","pred":"arg2Of","subj":"T1598","obj":"T1596"},{"id":"R1329","pred":"arg1Of","subj":"T1598","obj":"T1597"},{"id":"R1330","pred":"arg1Of","subj":"T1598","obj":"T1599"},{"id":"R1331","pred":"arg2Of","subj":"T1600","obj":"T1599"},{"id":"R1332","pred":"arg3Of","subj":"T1601","obj":"T1599"},{"id":"R1333","pred":"arg1Of","subj":"T1602","obj":"T1603"},{"id":"R1334","pred":"arg1Of","subj":"T1602","obj":"T1613"},{"id":"R1335","pred":"arg2Of","subj":"T1602","obj":"T1614"},{"id":"R1336","pred":"arg1Of","subj":"T1603","obj":"T1609"},{"id":"R1337","pred":"arg1Of","subj":"T1603","obj":"T1612"},{"id":"R1338","pred":"arg2Of","subj":"T1608","obj":"T1603"},{"id":"R1339","pred":"arg1Of","subj":"T1608","obj":"T1604"},{"id":"R1340","pred":"arg1Of","subj":"T1608","obj":"T1605"},{"id":"R1341","pred":"arg1Of","subj":"T1608","obj":"T1606"},{"id":"R1342","pred":"arg1Of","subj":"T1608","obj":"T1607"},{"id":"R1343","pred":"arg2Of","subj":"T1610","obj":"T1609"},{"id":"R1344","pred":"arg3Of","subj":"T1611","obj":"T1609"},{"id":"R1345","pred":"arg2Of","subj":"T1614","obj":"T1612"},{"id":"R1346","pred":"arg2Of","subj":"T1614","obj":"T1613"},{"id":"R1347","pred":"arg1Of","subj":"T1614","obj":"T1615"},{"id":"R1348","pred":"arg1Of","subj":"T1614","obj":"T1618"},{"id":"R1349","pred":"arg1Of","subj":"T1614","obj":"T1630"},{"id":"R1350","pred":"arg2Of","subj":"T1617","obj":"T1615"},{"id":"R1351","pred":"arg1Of","subj":"T1617","obj":"T1616"},{"id":"R1352","pred":"arg2Of","subj":"T1623","obj":"T1618"},{"id":"R1353","pred":"arg1Of","subj":"T1623","obj":"T1619"},{"id":"R1354","pred":"arg1Of","subj":"T1623","obj":"T1620"},{"id":"R1355","pred":"arg1Of","subj":"T1623","obj":"T1621"},{"id":"R1356","pred":"arg1Of","subj":"T1623","obj":"T1622"},{"id":"R1357","pred":"arg1Of","subj":"T1623","obj":"T1624"},{"id":"R1358","pred":"arg2Of","subj":"T1626","obj":"T1624"},{"id":"R1359","pred":"arg1Of","subj":"T1626","obj":"T1625"},{"id":"R1360","pred":"arg1Of","subj":"T1626","obj":"T1627"},{"id":"R1361","pred":"arg2Of","subj":"T1628","obj":"T1627"},{"id":"R1362","pred":"arg3Of","subj":"T1629","obj":"T1624"},{"id":"R1363","pred":"arg2Of","subj":"T1631","obj":"T1630"},{"id":"R1364","pred":"arg3Of","subj":"T1632","obj":"T1630"},{"id":"R1365","pred":"arg1Of","subj":"T1633","obj":"T1634"},{"id":"R1366","pred":"arg1Of","subj":"T1633","obj":"T1652"},{"id":"R1367","pred":"arg2Of","subj":"T1636","obj":"T1634"},{"id":"R1368","pred":"arg1Of","subj":"T1636","obj":"T1635"},{"id":"R1369","pred":"arg1Of","subj":"T1636","obj":"T1637"},{"id":"R1370","pred":"arg1Of","subj":"T1642","obj":"T1639"},{"id":"R1371","pred":"arg1Of","subj":"T1642","obj":"T1640"},{"id":"R1372","pred":"arg1Of","subj":"T1642","obj":"T1641"},{"id":"R1373","pred":"arg1Of","subj":"T1642","obj":"T1643"},{"id":"R1374","pred":"arg2Of","subj":"T1644","obj":"T1643"},{"id":"R1375","pred":"arg3Of","subj":"T1645","obj":"T1643"},{"id":"R1376","pred":"arg2Of","subj":"T1646","obj":"T1637"},{"id":"R1377","pred":"arg1Of","subj":"T1646","obj":"T1638"},{"id":"R1378","pred":"arg1Of","subj":"T1646","obj":"T1642"},{"id":"R1379","pred":"arg1Of","subj":"T1646","obj":"T1647"},{"id":"R1380","pred":"arg1Of","subj":"T1648","obj":"T1649"},{"id":"R1381","pred":"arg2Of","subj":"T1650","obj":"T1649"},{"id":"R1382","pred":"arg2Of","subj":"T1651","obj":"T1647"},{"id":"R1383","pred":"arg1Of","subj":"T1651","obj":"T1648"},{"id":"R1384","pred":"arg1Of","subj":"T1651","obj":"T1650"},{"id":"R1385","pred":"arg1Of","subj":"T1652","obj":"T1659"},{"id":"R1386","pred":"arg1Of","subj":"T1652","obj":"T1660"},{"id":"R1387","pred":"arg2Of","subj":"T1655","obj":"T1652"},{"id":"R1388","pred":"arg1Of","subj":"T1655","obj":"T1653"},{"id":"R1389","pred":"arg1Of","subj":"T1655","obj":"T1654"},{"id":"R1390","pred":"arg1Of","subj":"T1655","obj":"T1656"},{"id":"R1391","pred":"arg2Of","subj":"T1657","obj":"T1656"},{"id":"R1392","pred":"arg3Of","subj":"T1658","obj":"T1656"},{"id":"R1393","pred":"arg2Of","subj":"T1661","obj":"T1660"},{"id":"R1394","pred":"arg3Of","subj":"T1662","obj":"T1660"},{"id":"R1395","pred":"arg1Of","subj":"T1664","obj":"T1663"},{"id":"R1396","pred":"arg1Of","subj":"T1664","obj":"T1665"},{"id":"R1397","pred":"arg1Of","subj":"T1664","obj":"T1669"},{"id":"R1398","pred":"arg2Of","subj":"T1664","obj":"T1670"},{"id":"R1399","pred":"arg2Of","subj":"T1668","obj":"T1665"},{"id":"R1400","pred":"arg1Of","subj":"T1668","obj":"T1666"},{"id":"R1401","pred":"arg1Of","subj":"T1668","obj":"T1667"},{"id":"R1402","pred":"arg2Of","subj":"T1670","obj":"T1669"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T2215","span":{"begin":141,"end":143},"obj":"Anaphor"},{"id":"T2216","span":{"begin":105,"end":111},"obj":"Antecedent"},{"id":"T2217","span":{"begin":207,"end":210},"obj":"Anaphor"}],"relations":[{"id":"R1960","pred":"boundBy","subj":"T2215","obj":"T2216"},{"id":"R1961","pred":"boundBy","subj":"T2217","obj":"T2216"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T2490","span":{"begin":3,"end":5},"obj":"IN"},{"id":"T2491","span":{"begin":6,"end":11},"obj":"JJ"},{"id":"T2492","span":{"begin":12,"end":13},"obj":"NNP"},{"id":"T2493","span":{"begin":14,"end":19},"obj":"NNS"},{"id":"T2494","span":{"begin":20,"end":27},"obj":"NNS"},{"id":"T2495","span":{"begin":28,"end":30},"obj":"IN"},{"id":"T2496","span":{"begin":31,"end":35},"obj":"NN"},{"id":"T2497","span":{"begin":36,"end":38},"obj":"IN"},{"id":"T2498","span":{"begin":39,"end":47},"obj":"JJ"},{"id":"T2499","span":{"begin":47,"end":48},"obj":"NN"},{"id":"T2500","span":{"begin":48,"end":61},"obj":"JJ"},{"id":"T2501","span":{"begin":62,"end":65},"obj":"JJ"},{"id":"T2502","span":{"begin":66,"end":74},"obj":"NN"},{"id":"T2503","span":{"begin":75,"end":85},"obj":"NN"},{"id":"T2504","span":{"begin":86,"end":87},"obj":"NNP"},{"id":"T2505","span":{"begin":87,"end":89},"obj":"CD"},{"id":"T2506","span":{"begin":89,"end":90},"obj":"NNP"},{"id":"T2507","span":{"begin":90,"end":91},"obj":"."},{"id":"T2508","span":{"begin":92,"end":94},"obj":"IN"},{"id":"T2509","span":{"begin":95,"end":100},"obj":"NN"},{"id":"T2510","span":{"begin":101,"end":104},"obj":"IN"},{"id":"T2511","span":{"begin":105,"end":111},"obj":"NN"},{"id":"T2512","span":{"begin":112,"end":114},"obj":"TO"},{"id":"T2513","span":{"begin":115,"end":123},"obj":"VB"},{"id":"T2514","span":{"begin":124,"end":128},"obj":"NN"},{"id":"T2515","span":{"begin":129,"end":139},"obj":"NN"},{"id":"T2516","span":{"begin":139,"end":140},"obj":","},{"id":"T2517","span":{"begin":141,"end":143},"obj":"PRP"},{"id":"T2518","span":{"begin":144,"end":148},"obj":"MD"},{"id":"T2519","span":{"begin":149,"end":160},"obj":"VB"},{"id":"T2520","span":{"begin":161,"end":165},"obj":"IN"},{"id":"T2521","span":{"begin":166,"end":169},"obj":"DT"},{"id":"T2522","span":{"begin":170,"end":179},"obj":"NN"},{"id":"T2523","span":{"begin":180,"end":184},"obj":"IN"},{"id":"T2524","span":{"begin":185,"end":188},"obj":"DT"},{"id":"T2525","span":{"begin":189,"end":196},"obj":"NN"},{"id":"T2526","span":{"begin":197,"end":199},"obj":"TO"},{"id":"T2527","span":{"begin":200,"end":206},"obj":"VB"},{"id":"T2528","span":{"begin":207,"end":210},"obj":"PRP$"},{"id":"T2529","span":{"begin":211,"end":217},"obj":"NN"},{"id":"T2530","span":{"begin":218,"end":223},"obj":"NNS"},{"id":"T2531","span":{"begin":223,"end":224},"obj":"."},{"id":"T2532","span":{"begin":225,"end":233},"obj":"JJ"},{"id":"T2533","span":{"begin":234,"end":241},"obj":"JJ"},{"id":"T2534","span":{"begin":242,"end":252},"obj":"NN"},{"id":"T2535","span":{"begin":253,"end":255},"obj":"IN"},{"id":"T2536","span":{"begin":256,"end":262},"obj":"NN"},{"id":"T2537","span":{"begin":263,"end":272},"obj":"VBG"},{"id":"T2538","span":{"begin":273,"end":274},"obj":"NNP"},{"id":"T2539","span":{"begin":275,"end":279},"obj":"NN"},{"id":"T2540","span":{"begin":280,"end":288},"obj":"NN"},{"id":"T2541","span":{"begin":289,"end":299},"obj":"NN"},{"id":"T2542","span":{"begin":300,"end":303},"obj":"VBD"},{"id":"T2543","span":{"begin":304,"end":309},"obj":"JJ"},{"id":"T2544","span":{"begin":310,"end":322},"obj":"VBN"},{"id":"T2545","span":{"begin":323,"end":325},"obj":"IN"},{"id":"T2546","span":{"begin":326,"end":332},"obj":"NN"},{"id":"T2547","span":{"begin":333,"end":334},"obj":"NNP"},{"id":"T2548","span":{"begin":335,"end":340},"obj":"NNS"},{"id":"T2549","span":{"begin":341,"end":342},"obj":"NNP"},{"id":"T2550","span":{"begin":342,"end":344},"obj":"CD"},{"id":"T2551","span":{"begin":344,"end":345},"obj":"NNP"},{"id":"T2552","span":{"begin":346,"end":349},"obj":"CC"},{"id":"T2553","span":{"begin":350,"end":353},"obj":"VBD"},{"id":"T2554","span":{"begin":354,"end":362},"obj":"RB"},{"id":"T2555","span":{"begin":363,"end":372},"obj":"VBN"},{"id":"T2556","span":{"begin":373,"end":375},"obj":"IN"},{"id":"T2557","span":{"begin":376,"end":381},"obj":"JJ"},{"id":"T2558","span":{"begin":382,"end":383},"obj":"NNP"},{"id":"T2559","span":{"begin":384,"end":389},"obj":"NNS"},{"id":"T2560","span":{"begin":390,"end":399},"obj":"VBG"},{"id":"T2561","span":{"begin":400,"end":401},"obj":"NNP"},{"id":"T2562","span":{"begin":402,"end":406},"obj":"NN"},{"id":"T2563","span":{"begin":407,"end":415},"obj":"NN"},{"id":"T2564","span":{"begin":416,"end":419},"obj":"CC"},{"id":"T2565","span":{"begin":420,"end":431},"obj":"NN"},{"id":"T2566","span":{"begin":432,"end":443},"obj":"NN"},{"id":"T2567","span":{"begin":444,"end":445},"obj":"NNP"},{"id":"T2568","span":{"begin":445,"end":447},"obj":"CD"},{"id":"T2569","span":{"begin":447,"end":448},"obj":"NNP"},{"id":"T2570","span":{"begin":448,"end":449},"obj":"."},{"id":"T2571","span":{"begin":450,"end":456},"obj":"JJ"},{"id":"T2572","span":{"begin":457,"end":465},"obj":"VBZ"},{"id":"T2573","span":{"begin":466,"end":467},"obj":"DT"},{"id":"T2574","span":{"begin":468,"end":477},"obj":"JJ"},{"id":"T2575","span":{"begin":478,"end":485},"obj":"JJ"},{"id":"T2576","span":{"begin":486,"end":492},"obj":"NN"},{"id":"T2577","span":{"begin":493,"end":499},"obj":"NN"},{"id":"T2578","span":{"begin":500,"end":501},"obj":"NNP"},{"id":"T2579","span":{"begin":501,"end":503},"obj":"CD"},{"id":"T2580","span":{"begin":503,"end":504},"obj":"NNP"},{"id":"T2581","span":{"begin":505,"end":508},"obj":"CC"},{"id":"T2582","span":{"begin":509,"end":511},"obj":"VBZ"},{"id":"T2583","span":{"begin":512,"end":523},"obj":"VBN"},{"id":"T2584","span":{"begin":524,"end":528},"obj":"IN"},{"id":"T2585","span":{"begin":529,"end":532},"obj":"DT"},{"id":"T2586","span":{"begin":533,"end":540},"obj":"NN"},{"id":"T2587","span":{"begin":541,"end":543},"obj":"IN"},{"id":"T2588","span":{"begin":544,"end":547},"obj":"DT"},{"id":"T2589","span":{"begin":548,"end":555},"obj":"JJ"},{"id":"T2590","span":{"begin":556,"end":562},"obj":"NN"},{"id":"T2591","span":{"begin":563,"end":570},"obj":"NN"},{"id":"T2592","span":{"begin":571,"end":581},"obj":"NN"},{"id":"T2593","span":{"begin":582,"end":583},"obj":"-LRB-"},{"id":"T2594","span":{"begin":583,"end":587},"obj":"RB"},{"id":"T2595","span":{"begin":588,"end":593},"obj":"VBN"},{"id":"T2596","span":{"begin":594,"end":596},"obj":"IN"},{"id":"T2597","span":{"begin":597,"end":610},"obj":"NN"},{"id":"T2598","span":{"begin":610,"end":611},"obj":"-RRB-"},{"id":"T2599","span":{"begin":612,"end":613},"obj":"NNP"},{"id":"T2600","span":{"begin":613,"end":615},"obj":"CD"},{"id":"T2601","span":{"begin":615,"end":616},"obj":"NNP"},{"id":"T2602","span":{"begin":616,"end":617},"obj":"."},{"id":"T2603","span":{"begin":618,"end":626},"obj":"NN"},{"id":"T2604","span":{"begin":627,"end":629},"obj":"IN"},{"id":"T2605","span":{"begin":630,"end":631},"obj":"DT"},{"id":"T2606","span":{"begin":632,"end":638},"obj":"NN"},{"id":"T2607","span":{"begin":639,"end":651},"obj":"VBG"},{"id":"T2608","span":{"begin":652,"end":655},"obj":"DT"},{"id":"T2609","span":{"begin":656,"end":662},"obj":"JJ"},{"id":"T2610","span":{"begin":663,"end":670},"obj":"JJ"},{"id":"T2611","span":{"begin":671,"end":683},"obj":"NN"},{"id":"T2612","span":{"begin":684,"end":692},"obj":"NN"},{"id":"T2613","span":{"begin":693,"end":694},"obj":"-LRB-"},{"id":"T2614","span":{"begin":694,"end":697},"obj":"NNP"},{"id":"T2615","span":{"begin":697,"end":698},"obj":"-RRB-"},{"id":"T2616","span":{"begin":699,"end":705},"obj":"NN"},{"id":"T2617","span":{"begin":706,"end":708},"obj":"IN"},{"id":"T2618","span":{"begin":709,"end":715},"obj":"NN"},{"id":"T2619","span":{"begin":716,"end":719},"obj":"CC"},{"id":"T2620","span":{"begin":720,"end":725},"obj":"JJ"},{"id":"T2621","span":{"begin":726,"end":731},"obj":"NNS"},{"id":"T2622","span":{"begin":732,"end":740},"obj":"VBZ"},{"id":"T2623","span":{"begin":741,"end":744},"obj":"PRP$"},{"id":"T2624","span":{"begin":745,"end":752},"obj":"JJ"},{"id":"T2625","span":{"begin":753,"end":765},"obj":"NN"},{"id":"T2626","span":{"begin":766,"end":767},"obj":"NNP"},{"id":"T2627","span":{"begin":767,"end":769},"obj":"CD"},{"id":"T2628","span":{"begin":769,"end":770},"obj":"NNP"},{"id":"T2629","span":{"begin":770,"end":771},"obj":","},{"id":"T2630","span":{"begin":771,"end":772},"obj":"NNP"},{"id":"T2631","span":{"begin":772,"end":774},"obj":"CD"},{"id":"T2632","span":{"begin":774,"end":775},"obj":"NNP"},{"id":"T2633","span":{"begin":775,"end":776},"obj":"."},{"id":"T2634","span":{"begin":777,"end":780},"obj":"DT"},{"id":"T2635","span":{"begin":781,"end":789},"obj":"NN"},{"id":"T2636","span":{"begin":790,"end":792},"obj":"IN"},{"id":"T2637","span":{"begin":793,"end":796},"obj":"DT"},{"id":"T2638","span":{"begin":797,"end":807},"obj":"JJ"},{"id":"T2639","span":{"begin":808,"end":811},"obj":"NNP"},{"id":"T2640","span":{"begin":812,"end":823},"obj":"NN"},{"id":"T2641","span":{"begin":824,"end":826},"obj":"VBZ"},{"id":"T2642","span":{"begin":827,"end":836},"obj":"VBN"},{"id":"T2643","span":{"begin":837,"end":839},"obj":"IN"}],"relations":[{"id":"R2179","pred":"amod","subj":"T2491","obj":"T2493"},{"id":"R2180","pred":"auxpass","subj":"T2553","obj":"T2555"},{"id":"R2181","pred":"advmod","subj":"T2554","obj":"T2555"},{"id":"R2182","pred":"compound","subj":"T2492","obj":"T2493"},{"id":"R2183","pred":"conj","subj":"T2555","obj":"T2544"},{"id":"R2184","pred":"prep","subj":"T2556","obj":"T2555"},{"id":"R2185","pred":"amod","subj":"T2557","obj":"T2559"},{"id":"R2186","pred":"compound","subj":"T2493","obj":"T2494"},{"id":"R2187","pred":"compound","subj":"T2558","obj":"T2559"},{"id":"R2188","pred":"pobj","subj":"T2559","obj":"T2556"},{"id":"R2189","pred":"prep","subj":"T2560","obj":"T2555"},{"id":"R2190","pred":"pobj","subj":"T2494","obj":"T2490"},{"id":"R2191","pred":"compound","subj":"T2561","obj":"T2563"},{"id":"R2192","pred":"compound","subj":"T2562","obj":"T2563"},{"id":"R2193","pred":"pobj","subj":"T2563","obj":"T2560"},{"id":"R2194","pred":"prep","subj":"T2495","obj":"T2494"},{"id":"R2195","pred":"cc","subj":"T2564","obj":"T2563"},{"id":"R2196","pred":"compound","subj":"T2565","obj":"T2566"},{"id":"R2197","pred":"pobj","subj":"T2496","obj":"T2495"},{"id":"R2198","pred":"conj","subj":"T2566","obj":"T2563"},{"id":"R2199","pred":"nmod","subj":"T2567","obj":"T2569"},{"id":"R2200","pred":"nummod","subj":"T2568","obj":"T2569"},{"id":"R2201","pred":"prep","subj":"T2497","obj":"T2496"},{"id":"R2202","pred":"nmod","subj":"T2569","obj":"T2566"},{"id":"R2203","pred":"punct","subj":"T2570","obj":"T2544"},{"id":"R2204","pred":"nsubj","subj":"T2571","obj":"T2572"},{"id":"R2205","pred":"amod","subj":"T2498","obj":"T2503"},{"id":"R2206","pred":"nmod","subj":"T2499","obj":"T2503"},{"id":"R2207","pred":"ROOT","subj":"T2572","obj":"T2572"},{"id":"R2208","pred":"nmod","subj":"T2500","obj":"T2503"},{"id":"R2209","pred":"det","subj":"T2573","obj":"T2577"},{"id":"R2210","pred":"amod","subj":"T2574","obj":"T2577"},{"id":"R2211","pred":"amod","subj":"T2501","obj":"T2503"},{"id":"R2212","pred":"amod","subj":"T2575","obj":"T2576"},{"id":"R2213","pred":"compound","subj":"T2576","obj":"T2577"},{"id":"R2214","pred":"dobj","subj":"T2577","obj":"T2572"},{"id":"R2215","pred":"compound","subj":"T2502","obj":"T2503"},{"id":"R2216","pred":"nmod","subj":"T2578","obj":"T2580"},{"id":"R2217","pred":"nummod","subj":"T2579","obj":"T2580"},{"id":"R2218","pred":"appos","subj":"T2580","obj":"T2577"},{"id":"R2219","pred":"pobj","subj":"T2503","obj":"T2497"},{"id":"R2220","pred":"cc","subj":"T2581","obj":"T2572"},{"id":"R2221","pred":"nmod","subj":"T2504","obj":"T2506"},{"id":"R2222","pred":"auxpass","subj":"T2582","obj":"T2583"},{"id":"R2223","pred":"nummod","subj":"T2505","obj":"T2506"},{"id":"R2224","pred":"conj","subj":"T2583","obj":"T2572"},{"id":"R2225","pred":"prep","subj":"T2584","obj":"T2583"},{"id":"R2226","pred":"det","subj":"T2585","obj":"T2586"},{"id":"R2227","pred":"pobj","subj":"T2586","obj":"T2584"},{"id":"R2228","pred":"agent","subj":"T2587","obj":"T2583"},{"id":"R2229","pred":"appos","subj":"T2506","obj":"T2503"},{"id":"R2230","pred":"det","subj":"T2588","obj":"T2591"},{"id":"R2231","pred":"amod","subj":"T2589","obj":"T2591"},{"id":"R2232","pred":"compound","subj":"T2590","obj":"T2591"},{"id":"R2234","pred":"pobj","subj":"T2591","obj":"T2587"},{"id":"R2235","pred":"conj","subj":"T2592","obj":"T2583"},{"id":"R2236","pred":"punct","subj":"T2593","obj":"T2595"},{"id":"R2237","pred":"prep","subj":"T2508","obj":"T2519"},{"id":"R2238","pred":"advmod","subj":"T2594","obj":"T2595"},{"id":"R2239","pred":"acl","subj":"T2595","obj":"T2592"},{"id":"R2240","pred":"prep","subj":"T2596","obj":"T2595"},{"id":"R2241","pred":"pobj","subj":"T2509","obj":"T2508"},{"id":"R2242","pred":"pobj","subj":"T2597","obj":"T2596"},{"id":"R2243","pred":"punct","subj":"T2598","obj":"T2592"},{"id":"R2244","pred":"nmod","subj":"T2599","obj":"T2601"},{"id":"R2245","pred":"mark","subj":"T2510","obj":"T2513"},{"id":"R2246","pred":"nummod","subj":"T2600","obj":"T2601"},{"id":"R2247","pred":"dep","subj":"T2601","obj":"T2572"},{"id":"R2248","pred":"punct","subj":"T2602","obj":"T2572"},{"id":"R2249","pred":"nsubj","subj":"T2511","obj":"T2513"},{"id":"R2250","pred":"nsubj","subj":"T2603","obj":"T2622"},{"id":"R2251","pred":"prep","subj":"T2604","obj":"T2603"},{"id":"R2252","pred":"det","subj":"T2605","obj":"T2606"},{"id":"R2253","pred":"aux","subj":"T2512","obj":"T2513"},{"id":"R2254","pred":"pobj","subj":"T2606","obj":"T2604"},{"id":"R2255","pred":"acl","subj":"T2607","obj":"T2606"},{"id":"R2256","pred":"det","subj":"T2608","obj":"T2612"},{"id":"R2257","pred":"advcl","subj":"T2513","obj":"T2509"},{"id":"R2258","pred":"amod","subj":"T2609","obj":"T2612"},{"id":"R2259","pred":"amod","subj":"T2610","obj":"T2611"},{"id":"R2260","pred":"compound","subj":"T2514","obj":"T2515"},{"id":"R2261","pred":"compound","subj":"T2611","obj":"T2612"},{"id":"R2262","pred":"dobj","subj":"T2515","obj":"T2513"},{"id":"R2263","pred":"dobj","subj":"T2612","obj":"T2607"},{"id":"R2264","pred":"punct","subj":"T2613","obj":"T2612"},{"id":"R2265","pred":"appos","subj":"T2614","obj":"T2612"},{"id":"R2266","pred":"punct","subj":"T2516","obj":"T2519"},{"id":"R2267","pred":"punct","subj":"T2615","obj":"T2612"},{"id":"R2268","pred":"conj","subj":"T2616","obj":"T2606"},{"id":"R2269","pred":"prep","subj":"T2617","obj":"T2603"},{"id":"R2270","pred":"nsubj","subj":"T2517","obj":"T2519"},{"id":"R2271","pred":"pobj","subj":"T2618","obj":"T2617"},{"id":"R2272","pred":"cc","subj":"T2619","obj":"T2618"},{"id":"R2273","pred":"amod","subj":"T2620","obj":"T2621"},{"id":"R2274","pred":"aux","subj":"T2518","obj":"T2519"},{"id":"R2275","pred":"conj","subj":"T2621","obj":"T2618"},{"id":"R2276","pred":"ROOT","subj":"T2622","obj":"T2622"},{"id":"R2277","pred":"poss","subj":"T2623","obj":"T2625"},{"id":"R2278","pred":"amod","subj":"T2624","obj":"T2625"},{"id":"R2279","pred":"dobj","subj":"T2625","obj":"T2622"},{"id":"R2280","pred":"ROOT","subj":"T2519","obj":"T2519"},{"id":"R2281","pred":"nmod","subj":"T2626","obj":"T2628"},{"id":"R2282","pred":"prep","subj":"T2520","obj":"T2519"},{"id":"R2283","pred":"nummod","subj":"T2627","obj":"T2628"},{"id":"R2284","pred":"dobj","subj":"T2628","obj":"T2622"},{"id":"R2285","pred":"punct","subj":"T2629","obj":"T2628"},{"id":"R2286","pred":"det","subj":"T2521","obj":"T2522"},{"id":"R2287","pred":"conj","subj":"T2630","obj":"T2628"},{"id":"R2288","pred":"nummod","subj":"T2631","obj":"T2632"},{"id":"R2289","pred":"conj","subj":"T2632","obj":"T2628"},{"id":"R2290","pred":"pobj","subj":"T2522","obj":"T2520"},{"id":"R2291","pred":"punct","subj":"T2633","obj":"T2622"},{"id":"R2292","pred":"det","subj":"T2634","obj":"T2635"},{"id":"R2293","pred":"nsubjpass","subj":"T2635","obj":"T2642"},{"id":"R2294","pred":"prep","subj":"T2523","obj":"T2519"},{"id":"R2295","pred":"prep","subj":"T2636","obj":"T2635"},{"id":"R2296","pred":"det","subj":"T2637","obj":"T2638"},{"id":"R2297","pred":"pobj","subj":"T2638","obj":"T2636"},{"id":"R2298","pred":"det","subj":"T2524","obj":"T2525"},{"id":"R2299","pred":"compound","subj":"T2639","obj":"T2640"},{"id":"R2300","pred":"nsubjpass","subj":"T2640","obj":"T2642"},{"id":"R2301","pred":"auxpass","subj":"T2641","obj":"T2642"},{"id":"R2302","pred":"pobj","subj":"T2525","obj":"T2523"},{"id":"R2303","pred":"ROOT","subj":"T2642","obj":"T2642"},{"id":"R2304","pred":"agent","subj":"T2643","obj":"T2642"},{"id":"R2306","pred":"aux","subj":"T2526","obj":"T2527"},{"id":"R2310","pred":"advcl","subj":"T2527","obj":"T2519"},{"id":"R2313","pred":"poss","subj":"T2528","obj":"T2530"},{"id":"R2314","pred":"compound","subj":"T2529","obj":"T2530"},{"id":"R2316","pred":"dobj","subj":"T2530","obj":"T2527"},{"id":"R2320","pred":"punct","subj":"T2531","obj":"T2519"},{"id":"R2324","pred":"amod","subj":"T2532","obj":"T2534"},{"id":"R2327","pred":"amod","subj":"T2533","obj":"T2534"},{"id":"R2330","pred":"nsubjpass","subj":"T2534","obj":"T2544"},{"id":"R2334","pred":"prep","subj":"T2535","obj":"T2534"},{"id":"R2337","pred":"pobj","subj":"T2536","obj":"T2535"},{"id":"R2338","pred":"acl","subj":"T2537","obj":"T2534"},{"id":"R2341","pred":"compound","subj":"T2538","obj":"T2541"},{"id":"R2345","pred":"compound","subj":"T2539","obj":"T2540"},{"id":"R2350","pred":"compound","subj":"T2540","obj":"T2541"},{"id":"R2353","pred":"pobj","subj":"T2541","obj":"T2537"},{"id":"R2357","pred":"auxpass","subj":"T2542","obj":"T2544"},{"id":"R2361","pred":"advmod","subj":"T2543","obj":"T2544"},{"id":"R2366","pred":"ROOT","subj":"T2544","obj":"T2544"},{"id":"R2370","pred":"prep","subj":"T2545","obj":"T2544"},{"id":"R2373","pred":"compound","subj":"T2546","obj":"T2547"},{"id":"R2380","pred":"compound","subj":"T2547","obj":"T2548"},{"id":"R2385","pred":"pobj","subj":"T2548","obj":"T2545"},{"id":"R2389","pred":"nmod","subj":"T2549","obj":"T2551"},{"id":"R2393","pred":"nummod","subj":"T2550","obj":"T2551"},{"id":"R2398","pred":"appos","subj":"T2551","obj":"T2548"},{"id":"R2401","pred":"cc","subj":"T2552","obj":"T2544"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"GO-BP","denotations":[{"id":"T3234","span":{"begin":124,"end":139},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T3235","span":{"begin":478,"end":492},"obj":"http://purl.obolibrary.org/obo/GO_0051170"},{"id":"T3236","span":{"begin":548,"end":562},"obj":"http://purl.obolibrary.org/obo/GO_0051170"},{"id":"T3238","span":{"begin":493,"end":499},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T3240","span":{"begin":512,"end":523},"obj":"http://purl.obolibrary.org/obo/GO_0006810"},{"id":"T3242","span":{"begin":512,"end":540},"obj":"http://purl.obolibrary.org/obo/GO_0051169"},{"id":"T3244","span":{"begin":533,"end":570},"obj":"http://purl.obolibrary.org/obo/GO_0006606"},{"id":"T3245","span":{"begin":556,"end":570},"obj":"http://purl.obolibrary.org/obo/GO_0017038"},{"id":"T3246","span":{"begin":671,"end":683},"obj":"http://purl.obolibrary.org/obo/GO_0051179"},{"id":"T3247","span":{"begin":753,"end":765},"obj":"http://purl.obolibrary.org/obo/GO_0051179"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"GO-CC","denotations":[{"id":"T3311","span":{"begin":726,"end":731},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3308","span":{"begin":14,"end":19},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3309","span":{"begin":335,"end":340},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3310","span":{"begin":384,"end":389},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T3317","span":{"begin":170,"end":179},"obj":"http://purl.obolibrary.org/obo/GO_0005737"},{"id":"T3318","span":{"begin":189,"end":196},"obj":"http://purl.obolibrary.org/obo/GO_0005634"},{"id":"T3319","span":{"begin":533,"end":540},"obj":"http://purl.obolibrary.org/obo/GO_0005634"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"sentences","denotations":[{"id":"T1302","span":{"begin":92,"end":224},"obj":"Sentence"},{"id":"T1303","span":{"begin":225,"end":449},"obj":"Sentence"},{"id":"T1304","span":{"begin":450,"end":617},"obj":"Sentence"},{"id":"T1305","span":{"begin":618,"end":776},"obj":"Sentence"},{"id":"T59","span":{"begin":92,"end":224},"obj":"Sentence"},{"id":"T60","span":{"begin":225,"end":449},"obj":"Sentence"},{"id":"T61","span":{"begin":450,"end":617},"obj":"Sentence"},{"id":"T62","span":{"begin":618,"end":776},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"events-check-again","denotations":[{"id":"T3580","span":{"begin":105,"end":111},"obj":"Protein"},{"id":"T3581","span":{"begin":149,"end":160},"obj":"Localization"},{"id":"T3582","span":{"begin":189,"end":196},"obj":"Entity"},{"id":"T3583","span":{"begin":200,"end":206},"obj":"Binding"},{"id":"T3584","span":{"begin":211,"end":217},"obj":"Binding"},{"id":"T3585","span":{"begin":234,"end":241},"obj":"Entity"},{"id":"T3586","span":{"begin":242,"end":252},"obj":"Localization"},{"id":"T3587","span":{"begin":256,"end":262},"obj":"Protein"},{"id":"T3588","span":{"begin":263,"end":272},"obj":"Positive_regulation"},{"id":"T3589","span":{"begin":390,"end":399},"obj":"Positive_regulation"},{"id":"T3590","span":{"begin":450,"end":456},"obj":"Protein"},{"id":"T3591","span":{"begin":512,"end":523},"obj":"Localization"},{"id":"T3592","span":{"begin":533,"end":540},"obj":"Entity"},{"id":"T3593","span":{"begin":656,"end":662},"obj":"Protein"}],"relations":[{"id":"R3062","pred":"themeOf","subj":"T3580","obj":"T3581"},{"id":"R3063","pred":"themeOf","subj":"T3580","obj":"T3583"},{"id":"R3064","pred":"themeOf","subj":"T3580","obj":"T3584"},{"id":"R3065","pred":"locationOf","subj":"T3582","obj":"T3581"},{"id":"R3069","pred":"locationOf","subj":"T3585","obj":"T3586"},{"id":"R3070","pred":"themeOf","subj":"T3586","obj":"T3588"},{"id":"R3071","pred":"themeOf","subj":"T3586","obj":"T3589"},{"id":"R3073","pred":"themeOf","subj":"T3587","obj":"T3586"},{"id":"R3075","pred":"themeOf","subj":"T3590","obj":"T3591"},{"id":"R3076","pred":"locationOf","subj":"T3592","obj":"T3591"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T1205","span":{"begin":105,"end":111},"obj":"Protein"},{"id":"T1206","span":{"begin":149,"end":160},"obj":"Localization"},{"id":"T1207","span":{"begin":189,"end":196},"obj":"Entity"},{"id":"T1208","span":{"begin":200,"end":206},"obj":"Binding"},{"id":"T1209","span":{"begin":211,"end":217},"obj":"Binding"},{"id":"T1210","span":{"begin":234,"end":241},"obj":"Entity"},{"id":"T1211","span":{"begin":242,"end":252},"obj":"Localization"},{"id":"T1212","span":{"begin":256,"end":262},"obj":"Protein"},{"id":"T1213","span":{"begin":263,"end":272},"obj":"Positive_regulation"},{"id":"T1214","span":{"begin":390,"end":399},"obj":"Positive_regulation"},{"id":"T1215","span":{"begin":450,"end":456},"obj":"Protein"},{"id":"T1216","span":{"begin":512,"end":523},"obj":"Localization"},{"id":"T1217","span":{"begin":533,"end":540},"obj":"Entity"},{"id":"T1218","span":{"begin":656,"end":662},"obj":"Protein"}],"relations":[{"id":"R971","pred":"themeOf","subj":"T1205","obj":"T1206"},{"id":"R972","pred":"themeOf","subj":"T1205","obj":"T1208"},{"id":"R973","pred":"themeOf","subj":"T1205","obj":"T1209"},{"id":"R974","pred":"locationOf","subj":"T1207","obj":"T1206"},{"id":"R975","pred":"locationOf","subj":"T1210","obj":"T1211"},{"id":"R976","pred":"themeOf","subj":"T1211","obj":"T1213"},{"id":"R977","pred":"themeOf","subj":"T1211","obj":"T1214"},{"id":"R978","pred":"themeOf","subj":"T1212","obj":"T1211"},{"id":"R979","pred":"themeOf","subj":"T1215","obj":"T1216"},{"id":"R980","pred":"locationOf","subj":"T1217","obj":"T1216"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T2240","span":{"begin":44,"end":47},"obj":"P09693"},{"id":"T2241","span":{"begin":44,"end":47},"obj":"P20963"},{"id":"T2242","span":{"begin":44,"end":47},"obj":"P04234"},{"id":"T2243","span":{"begin":44,"end":47},"obj":"P07766"},{"id":"T2244","span":{"begin":48,"end":52},"obj":"P10747"},{"id":"T2245","span":{"begin":105,"end":111},"obj":"P23771"},{"id":"T2246","span":{"begin":256,"end":262},"obj":"P23771"},{"id":"T2247","span":{"begin":450,"end":456},"obj":"P23771"},{"id":"T2248","span":{"begin":656,"end":662},"obj":"P23771"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}

{"project":"test2","denotations":[{"id":"T1098","span":{"begin":105,"end":111},"obj":"Protein"},{"id":"T1099","span":{"begin":149,"end":160},"obj":"Localization"},{"id":"T1100","span":{"begin":189,"end":196},"obj":"Entity"},{"id":"T1101","span":{"begin":225,"end":233},"obj":"Positive_regulation"},{"id":"T1102","span":{"begin":234,"end":241},"obj":"Entity"},{"id":"T1103","span":{"begin":242,"end":252},"obj":"Localization"},{"id":"T1104","span":{"begin":256,"end":262},"obj":"Protein"},{"id":"T1105","span":{"begin":263,"end":272},"obj":"Positive_regulation"},{"id":"T1106","span":{"begin":289,"end":299},"obj":"Positive_regulation"},{"id":"T1107","span":{"begin":450,"end":456},"obj":"Protein"},{"id":"T1108","span":{"begin":486,"end":492},"obj":"Localization"},{"id":"T1109","span":{"begin":533,"end":540},"obj":"Entity"},{"id":"T1110","span":{"begin":556,"end":562},"obj":"Localization"},{"id":"T1111","span":{"begin":656,"end":662},"obj":"Protein"},{"id":"T1112","span":{"begin":827,"end":836},"obj":"Regulation"}],"relations":[{"id":"R901","pred":"themeOf","subj":"T1098","obj":"T1099"},{"id":"R902","pred":"locationOf","subj":"T1100","obj":"T1099"},{"id":"R903","pred":"locationOf","subj":"T1102","obj":"T1103"},{"id":"R904","pred":"themeOf","subj":"T1103","obj":"T1101"},{"id":"R905","pred":"themeOf","subj":"T1103","obj":"T1105"},{"id":"R906","pred":"themeOf","subj":"T1104","obj":"T1103"},{"id":"R907","pred":"themeOf","subj":"T1107","obj":"T1108"},{"id":"R908","pred":"themeOf","subj":"T1107","obj":"T1110"},{"id":"R909","pred":"locationOf","subj":"T1109","obj":"T1108"}],"text":"NA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].\nIn order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes. Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12]. GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12]. Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14]. The affinity of the importin-α–NLS interaction is regulated by phos"}