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PMC:2674207 / 7233-12325 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
19436703-16903918-86274449 330-331 16903918 denotes 1
19436703-10525032-86274450 457-458 10525032 denotes 2
19436703-16467870-86274451 461-462 16467870 denotes 3
19436703-11336690-86274452 604-605 11336690 denotes 4
19436703-11893731-86274453 608-609 11893731 denotes 7
19436703-10549629-86274454 863-864 10549629 denotes 8
19436703-11390432-86274455 867-868 11390432 denotes 9
19436703-14769923-86274456 990-992 14769923 denotes 10
19436703-15087456-86274457 1071-1073 15087456 denotes 11
19436703-17277157-86274458 1212-1214 17277157 denotes 12
19436703-11751746-86274459 1467-1469 11751746 denotes 13
19436703-17277157-86274460 1570-1572 17277157 denotes 12
19436703-8114750-86274461 1626-1628 8114750 denotes 14
19436703-17277157-86274462 1738-1740 17277157 denotes 12
19436703-17277157-86274463 1892-1894 17277157 denotes 12
19436703-8114750-86274464 1897-1899 8114750 denotes 14
19436703-15350979-86274465 1982-1984 15350979 denotes 15
19436703-17277157-86274466 2188-2190 17277157 denotes 12
19436703-7510080-86274467 2350-2352 7510080 denotes 16
19436703-16236742-86274468 2912-2914 16236742 denotes 17
19436703-16604091-86274469 2917-2919 16604091 denotes 18
19436703-3123217-86274470 3031-3033 3123217 denotes 19
19436703-17314103-86274471 3066-3068 17314103 denotes 20
19436703-15110988-86274472 3170-3172 15110988 denotes 21
19436703-9891038-86274473 3235-3237 9891038 denotes 22
19436703-15004228-86274474 3407-3409 15004228 denotes 23
19436703-15004228-86274475 3600-3602 15004228 denotes 23
19436703-16610357-86274476 3724-3726 16610357 denotes 24
19436703-16610357-86274477 3890-3892 16610357 denotes 24
19436703-18049904-86274478 3895-3897 18049904 denotes 26
19436703-15591061-86274479 3988-3990 15591061 denotes 27
19436703-15496417-86274480 3993-3995 15496417 denotes 28
19436703-8532532-86274481 4198-4200 8532532 denotes 29
19436703-9780145-86274482 4257-4259 9780145 denotes 30
19436703-12876556-86274483 4262-4264 12876556 denotes 32
19436703-15826950-86274484 4337-4339 15826950 denotes 33
T43001 330-331 16903918 denotes 1
T70873 457-458 10525032 denotes 2
T67559 461-462 16467870 denotes 3
T42453 604-605 11336690 denotes 4
T56933 608-609 11893731 denotes 7
T99552 863-864 10549629 denotes 8
T78387 867-868 11390432 denotes 9
T31861 990-992 14769923 denotes 10
T54483 1071-1073 15087456 denotes 11
T49366 1212-1214 17277157 denotes 12
T50729 1467-1469 11751746 denotes 13
T71477 1570-1572 17277157 denotes 12
T49898 1626-1628 8114750 denotes 14
T29972 1738-1740 17277157 denotes 12
T24249 1892-1894 17277157 denotes 12
T62255 1897-1899 8114750 denotes 14
T15669 1982-1984 15350979 denotes 15
T56526 2188-2190 17277157 denotes 12
T37660 2350-2352 7510080 denotes 16
T62921 2912-2914 16236742 denotes 17
T62400 2917-2919 16604091 denotes 18
T78453 3031-3033 3123217 denotes 19
T63706 3066-3068 17314103 denotes 20
T47506 3170-3172 15110988 denotes 21
T32938 3235-3237 9891038 denotes 22
T41384 3407-3409 15004228 denotes 23
T57828 3600-3602 15004228 denotes 23
T19733 3724-3726 16610357 denotes 24
T68074 3890-3892 16610357 denotes 24
T88055 3895-3897 18049904 denotes 26
T58328 3988-3990 15591061 denotes 27
T37253 3993-3995 15496417 denotes 28
T40125 4198-4200 8532532 denotes 29
T36194 4257-4259 9780145 denotes 30
T8767 4262-4264 12876556 denotes 32
T27072 4337-4339 15826950 denotes 33

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T1321 13-25 NN denotes Inflammation
T1322 26-28 IN denotes in
T1323 29-37 JJ denotes allergic
T1324 38-46 NN denotes diseases
T1325 47-51 JJ denotes such
T1326 52-54 IN denotes as
T1327 55-61 NN denotes asthma
T1328 61-62 -COMMA- denotes ,
T1329 63-71 NN denotes rhinitis
T1330 71-72 -COMMA- denotes ,
T1331 73-76 CC denotes and
T1332 77-83 JJ denotes atopic
T1333 84-94 NN denotes dermatitis
T1334 95-97 VB denotes is
T1335 98-106 VB denotes mediated
T1336 107-110 IN denotes via
T1337 111-121 NN denotes expression
T1338 122-124 IN denotes of
T1339 125-128 DT denotes the
T1340 129-138 NN denotes cytokines
T1341 139-150 NN denotes interleukin
T1342 151-152 -LRB- denotes (
T1343 152-154 NN denotes IL
T1344 154-155 -RRB- denotes )
T1345 155-157 CD denotes -4
T1346 157-158 -COMMA- denotes ,
T1347 159-163 NN denotes IL-5
T1348 163-164 -COMMA- denotes ,
T1349 165-168 CC denotes and
T1350 169-174 NN denotes IL-13
T1351 175-179 IN denotes from
T1352 180-181 NN denotes T
T1353 182-190 NN denotes helper-2
T1354 191-192 -LRB- denotes (
T1355 192-195 NN denotes Th2
T1356 195-196 -RRB- denotes )
T1357 197-202 NN denotes cells
T1358 204-208 NN denotes IL-4
T1359 209-212 CC denotes and
T1360 213-218 NN denotes IL-13
T1361 219-227 VB denotes regulate
T1362 228-231 DT denotes the
T1363 232-242 NN denotes expression
T1364 243-245 IN denotes of
T1365 246-249 NN denotes IgE
T1366 250-254 IN denotes from
T1367 255-256 NN denotes B
T1368 257-268 NN denotes lymphocytes
T1369 268-269 -COMMA- denotes ,
T1370 270-277 IN denotes whereas
T1371 278-282 NN denotes IL-5
T1372 283-288 VB denotes plays
T1373 289-290 DT denotes a
T1374 291-294 JJ denotes key
T1375 295-299 NN denotes role
T1376 300-302 IN denotes in
T1377 303-315 JJ denotes eosinophilic
T1378 316-328 NN denotes inflammation
T1379 329-330 -LRB- denotes [
T1380 330-331 CD denotes 1
T1381 331-332 -RRB- denotes ]
T1382 334-337 NN denotes Th2
T1383 338-347 NN denotes cytokines
T1384 348-351 VB denotes are
T1385 352-361 VB denotes regulated
T1386 362-364 IN denotes by
T1387 365-368 DT denotes the
T1388 369-373 NN denotes zinc
T1389 374-380 NN denotes finger
T1390 381-394 NN denotes transcription
T1391 395-401 NN denotes factor
T1392 402-408 NN denotes GATA-3
T1393 408-409 -COMMA- denotes ,
T1394 410-415 WDT denotes which
T1395 416-418 VB denotes is
T1396 419-432 RB denotes predominantly
T1397 433-442 VB denotes expressed
T1398 443-445 IN denotes in
T1399 446-449 NN denotes Th2
T1400 450-455 NN denotes cells
T1401 456-457 -LRB- denotes [
T1402 457-458 CD denotes 2
T1403 458-459 -RRB- denotes ]
T1404 459-460 -COMMA- denotes ,
T1405 460-461 -LRB- denotes [
T1406 461-462 CD denotes 3
T1407 462-463 -RRB- denotes ]
T1408 465-471 NN denotes GATA-3
T1409 472-482 VB denotes determines
T1410 483-486 NN denotes Th2
T1411 487-491 NN denotes cell
T1412 492-507 NN denotes differentiation
T1413 508-511 CC denotes and
T1414 512-523 RB denotes selectively
T1415 524-533 VB denotes activates
T1416 534-537 DT denotes the
T1417 538-547 NN denotes promoters
T1418 548-550 IN denotes of
T1419 551-555 NN denotes IL-4
T1420 555-556 -COMMA- denotes ,
T1421 557-561 NN denotes IL-5
T1422 561-562 -COMMA- denotes ,
T1423 563-566 CC denotes and
T1424 567-572 NN denotes IL-13
T1425 573-580 IN denotes through
T1426 581-590 NN denotes chromatin
T1427 591-602 VB denotes remodelling
T1428 603-604 -LRB- denotes [
T1429 604-605 CD denotes 4
T1430 605-606 -RRB- denotes ]
T1431 606-607 NN denotes –
T1432 607-608 -LRB- denotes [
T1433 608-609 CD denotes 7
T1434 609-610 -RRB- denotes ]
T1435 612-615 DT denotes The
T1436 616-619 JJ denotes key
T1437 620-624 NN denotes role
T1438 625-627 IN denotes of
T1439 628-634 NN denotes GATA-3
T1440 635-637 IN denotes in
T1441 638-646 JJ denotes allergic
T1442 647-653 NN denotes airway
T1443 654-666 NN denotes inflammation
T1444 667-670 VB denotes has
T1445 671-675 VB denotes been
T1446 676-688 VB denotes demonstrated
T1447 689-691 IN denotes in
T1448 692-696 NN denotes mice
T1449 697-699 IN denotes by
T1450 700-703 DT denotes the
T1451 704-711 VB denotes reduced
T1452 712-719 NN denotes release
T1453 720-722 IN denotes of
T1454 723-726 NN denotes Th2
T1455 727-736 NN denotes cytokines
T1456 737-739 IN denotes in
T1457 740-747 NN denotes animals
T1458 748-755 VB denotes treated
T1459 756-760 IN denotes with
T1460 761-778 JJ denotes dominant-negative
T1461 779-786 NN denotes mutants
T1462 787-789 IN denotes of
T1463 790-796 NN denotes GATA-3
T1464 797-800 CC denotes and
T1465 801-803 IN denotes by
T1466 804-809 JJ denotes local
T1467 810-821 NN denotes application
T1468 822-824 IN denotes of
T1469 825-834 JJ denotes antisense
T1470 835-851 NN denotes oligonucleotides
T1471 852-854 TO denotes to
T1472 855-861 NN denotes GATA-3
T1473 862-863 -LRB- denotes [
T1474 863-864 CD denotes 8
T1475 864-865 -RRB- denotes ]
T1476 865-866 -COMMA- denotes ,
T1477 866-867 -LRB- denotes [
T1478 867-868 CD denotes 9
T1479 868-869 -RRB- denotes ]
T1480 871-882 RB denotes Furthermore
T1481 882-883 -COMMA- denotes ,
T1482 884-895 JJ denotes conditional
T1483 896-905 NN denotes knock-out
T1484 906-908 IN denotes of
T1485 909-912 DT denotes the
T1486 913-918 NN denotes Gata3
T1487 919-923 NN denotes gene
T1488 924-926 IN denotes in
T1489 927-931 NN denotes mice
T1490 932-939 VB denotes reduces
T1491 940-950 NN denotes expression
T1492 951-953 IN denotes of
T1493 954-957 NN denotes Th2
T1494 958-967 NN denotes cytokines
T1495 968-970 FW denotes in
T1496 971-976 FW denotes vitro
T1497 977-980 CC denotes and
T1498 981-983 FW denotes in
T1499 984-988 FW denotes vivo
T1500 989-990 -LRB- denotes [
T1501 990-992 CD denotes 10
T1502 992-993 -RRB- denotes ]
T1503 993-994 -COMMA- denotes ,
T1504 995-998 CC denotes and
T1505 999-1006 JJ denotes similar
T1506 1007-1014 NN denotes results
T1507 1015-1019 VB denotes have
T1508 1020-1024 VB denotes been
T1509 1025-1033 VB denotes reported
T1510 1034-1036 IN denotes in
T1511 1037-1045 VB denotes isolated
T1512 1046-1052 JJ denotes murine
T1513 1053-1057 JJ denotes CD4+
T1514 1058-1069 NN denotes lymphocytes
T1515 1070-1071 -LRB- denotes [
T1516 1071-1073 CD denotes 11
T1517 1073-1074 -RRB- denotes ]
T1518 1076-1083 RB denotes Finally
T1519 1083-1084 -COMMA- denotes ,
T1520 1085-1094 NN denotes knockdown
T1521 1095-1097 IN denotes of
T1522 1098-1104 NN denotes GATA-3
T1523 1105-1115 NN denotes expression
T1524 1116-1121 VB denotes using
T1525 1122-1127 NN denotes siRNA
T1526 1128-1130 IN denotes in
T1527 1131-1136 JJ denotes human
T1528 1137-1138 NN denotes T
T1529 1139-1144 NN denotes cells
T1530 1145-1152 VB denotes results
T1531 1153-1155 IN denotes in
T1532 1156-1160 NN denotes loss
T1533 1161-1163 IN denotes of
T1534 1164-1186 JJ denotes anti-CD3/CD28-mediated
T1535 1187-1190 NN denotes Th2
T1536 1191-1199 NN denotes cytokine
T1537 1200-1210 NN denotes expression
T1538 1211-1212 -LRB- denotes [
T1539 1212-1214 CD denotes 12
T1540 1214-1215 -RRB- denotes ]
T1541 1217-1219 IN denotes In
T1542 1220-1225 NN denotes order
T1543 1226-1229 IN denotes for
T1544 1230-1236 NN denotes GATA-3
T1545 1237-1239 TO denotes to
T1546 1240-1248 VB denotes regulate
T1547 1249-1253 NN denotes gene
T1548 1254-1264 NN denotes expression
T1549 1264-1265 -COMMA- denotes ,
T1550 1266-1268 PRP denotes it
T1551 1269-1273 MD denotes must
T1552 1274-1285 VB denotes translocate
T1553 1286-1290 IN denotes from
T1554 1291-1294 DT denotes the
T1555 1295-1304 NN denotes cytoplasm
T1556 1305-1309 IN denotes into
T1557 1310-1313 DT denotes the
T1558 1314-1321 NN denotes nucleus
T1559 1322-1324 TO denotes to
T1560 1325-1331 VB denotes access
T1561 1332-1335 PRP-DOLLAR- denotes its
T1562 1336-1342 NN denotes target
T1563 1343-1348 NN denotes genes
T1564 1350-1358 VB denotes Enhanced
T1565 1359-1366 JJ denotes nuclear
T1566 1367-1377 NN denotes expression
T1567 1378-1380 IN denotes of
T1568 1381-1387 NN denotes GATA-3
T1569 1388-1397 VB denotes following
T1570 1398-1399 NN denotes T
T1571 1400-1404 NN denotes cell
T1572 1405-1413 NN denotes receptor
T1573 1414-1424 NN denotes activation
T1574 1425-1428 VB denotes was
T1575 1429-1434 RB denotes first
T1576 1435-1447 VB denotes demonstrated
T1577 1448-1450 IN denotes in
T1578 1451-1457 JJ denotes murine
T1579 1458-1459 NN denotes T
T1580 1460-1465 NN denotes cells
T1581 1466-1467 -LRB- denotes [
T1582 1467-1469 CD denotes 13
T1583 1469-1470 -RRB- denotes ]
T1584 1471-1474 CC denotes and
T1585 1475-1478 VB denotes was
T1586 1479-1487 RB denotes recently
T1587 1488-1497 VB denotes confirmed
T1588 1498-1500 IN denotes in
T1589 1501-1506 JJ denotes human
T1590 1507-1508 NN denotes T
T1591 1509-1514 NN denotes cells
T1592 1515-1524 VB denotes following
T1593 1525-1526 NN denotes T
T1594 1527-1531 NN denotes cell
T1595 1532-1540 NN denotes receptor
T1596 1541-1544 CC denotes and
T1597 1545-1556 NN denotes co-receptor
T1598 1557-1568 NN denotes stimulation
T1599 1569-1570 -LRB- denotes [
T1600 1570-1572 CD denotes 12
T1601 1572-1573 -RRB- denotes ]
T1602 1575-1581 NN denotes GATA-3
T1603 1582-1590 VB denotes contains
T1604 1591-1592 DT denotes a
T1605 1593-1602 JJ denotes classical
T1606 1603-1610 JJ denotes nuclear
T1607 1611-1617 NN denotes import
T1608 1618-1624 NN denotes signal
T1609 1625-1626 -LRB- denotes [
T1610 1626-1628 CD denotes 14
T1611 1628-1629 -RRB- denotes ]
T1612 1630-1633 CC denotes and
T1613 1634-1636 VB denotes is
T1614 1637-1648 VB denotes transported
T1615 1649-1653 IN denotes into
T1616 1654-1657 DT denotes the
T1617 1658-1665 NN denotes nucleus
T1618 1666-1668 IN denotes by
T1619 1669-1672 DT denotes the
T1620 1673-1680 JJ denotes nuclear
T1621 1681-1687 NN denotes import
T1622 1688-1695 NN denotes protein
T1623 1696-1706 NN denotes importin-α
T1624 1707-1708 -LRB- denotes (
T1625 1708-1712 RB denotes also
T1626 1713-1718 VB denotes known
T1627 1719-1721 IN denotes as
T1628 1722-1735 NN denotes karyopherin-α
T1629 1735-1736 -RRB- denotes )
T1630 1737-1738 -LRB- denotes [
T1631 1738-1740 CD denotes 12
T1632 1740-1741 -RRB- denotes ]
T1633 1743-1751 NN denotes Deletion
T1634 1752-1754 IN denotes of
T1635 1755-1756 DT denotes a
T1636 1757-1763 NN denotes region
T1637 1764-1776 VB denotes encompassing
T1638 1777-1780 DT denotes the
T1639 1781-1787 NN denotes GATA-3
T1640 1788-1795 JJ denotes nuclear
T1641 1796-1808 NN denotes localisation
T1642 1809-1817 NN denotes sequence
T1643 1818-1819 -LRB- denotes (
T1644 1819-1822 NN denotes NLS
T1645 1822-1823 -RRB- denotes )
T1646 1824-1830 NN denotes region
T1647 1831-1833 IN denotes in
T1648 1834-1840 JJ denotes murine
T1649 1841-1844 CC denotes and
T1650 1845-1850 JJ denotes human
T1651 1851-1856 NN denotes cells
T1652 1857-1865 VB denotes prevents
T1653 1866-1869 PRP-DOLLAR- denotes its
T1654 1870-1877 JJ denotes nuclear
T1655 1878-1890 NN denotes localisation
T1656 1891-1892 -LRB- denotes [
T1657 1892-1894 CD denotes 12
T1658 1894-1895 -RRB- denotes ]
T1659 1895-1896 -COMMA- denotes ,
T1660 1896-1897 -LRB- denotes [
T1661 1897-1899 CD denotes 14
T1662 1899-1900 -RRB- denotes ]
T1663 1902-1905 DT denotes The
T1664 1906-1914 NN denotes affinity
T1665 1915-1917 IN denotes of
T1666 1918-1921 DT denotes the
T1667 1922-1936 JJ denotes importin-α–NLS
T1668 1937-1948 NN denotes interaction
T1669 1949-1951 VB denotes is
T1670 1952-1961 VB denotes regulated
T1671 1962-1964 IN denotes by
T1672 1965-1980 NN denotes phosphorylation
T1673 1981-1982 -LRB- denotes [
T1674 1982-1984 CD denotes 15
T1675 1984-1985 -RRB- denotes ]
T1676 1985-1986 -COMMA- denotes ,
T1677 1987-1990 CC denotes and
T1678 1991-1993 PRP denotes we
T1679 1994-1998 VB denotes have
T1680 1999-2004 VB denotes shown
T1681 2005-2009 IN denotes that
T1682 2010-2013 NN denotes p38
T1683 2014-2031 JJ denotes mitogen-activated
T1684 2032-2039 NN denotes protein
T1685 2040-2046 NN denotes kinase
T1686 2047-2048 -LRB- denotes (
T1687 2048-2052 NN denotes MAPK
T1688 2052-2053 -RRB- denotes )
T1689 2054-2059 VB denotes plays
T1690 2060-2061 DT denotes a
T1691 2062-2070 JJ denotes critical
T1692 2071-2075 NN denotes role
T1693 2076-2078 IN denotes in
T1694 2079-2094 VB denotes phosphorylating
T1695 2095-2101 NN denotes GATA-3
T1696 2102-2104 TO denotes to
T1697 2105-2112 VB denotes enhance
T1698 2113-2116 PRP-DOLLAR- denotes its
T1699 2117-2128 NN denotes interaction
T1700 2129-2133 IN denotes with
T1701 2134-2144 JJ denotes importin-α
T1702 2145-2148 CC denotes and
T1703 2149-2159 JJ denotes subsequent
T1704 2160-2169 NN denotes transport
T1705 2170-2174 IN denotes into
T1706 2175-2178 DT denotes the
T1707 2179-2186 NN denotes nucleus
T1708 2187-2188 -LRB- denotes [
T1709 2188-2190 CD denotes 12
T1710 2190-2191 -RRB- denotes ]
T1711 2193-2208 NN denotes Corticosteroids
T1712 2209-2212 VB denotes are
T1713 2213-2219 RB denotes highly
T1714 2220-2229 JJ denotes effective
T1715 2230-2232 IN denotes in
T1716 2233-2236 DT denotes the
T1717 2237-2246 NN denotes treatment
T1718 2247-2249 IN denotes of
T1719 2250-2258 JJ denotes allergic
T1720 2259-2271 NN denotes inflammation
T1721 2271-2272 -COMMA- denotes ,
T1722 2273-2277 IN denotes with
T1723 2278-2284 JJ denotes marked
T1724 2285-2296 NN denotes suppression
T1725 2297-2299 IN denotes of
T1726 2300-2303 NN denotes Th2
T1727 2304-2313 NN denotes cytokines
T1728 2314-2316 IN denotes in
T1729 2317-2324 NN denotes airways
T1730 2325-2327 IN denotes of
T1731 2328-2336 NN denotes patients
T1732 2337-2341 IN denotes with
T1733 2342-2348 NN denotes asthma
T1734 2349-2350 -LRB- denotes [
T1735 2350-2352 CD denotes 16
T1736 2352-2353 -RRB- denotes ]
T1737 2355-2370 NN denotes Corticosteroids
T1738 2371-2378 VB denotes mediate
T1739 2379-2384 PRP-DOLLAR- denotes their
T1740 2385-2402 JJ denotes anti-inflammatory
T1741 2403-2410 NN denotes effects
T1742 2411-2418 IN denotes through
T1743 2419-2426 NN denotes binding
T1744 2427-2429 TO denotes to
T1745 2430-2444 NN denotes glucocorticoid
T1746 2445-2454 NN denotes receptors
T1747 2455-2456 -LRB- denotes (
T1748 2456-2459 NN denotes GRs
T1749 2459-2460 -RRB- denotes )
T1750 2460-2461 -COMMA- denotes ,
T1751 2462-2467 WDT denotes which
T1752 2468-2472 RB denotes then
T1753 2473-2484 VB denotes translocate
T1754 2485-2487 TO denotes to
T1755 2488-2491 DT denotes the
T1756 2492-2499 NN denotes nucleus
T1757 2500-2505 WRB denotes where
T1758 2506-2510 PRP denotes they
T1759 2511-2519 VB denotes interact
T1760 2520-2524 IN denotes with
T1761 2525-2539 NN denotes glucocorticoid
T1762 2540-2548 NN denotes response
T1763 2549-2557 NN denotes elements
T1764 2558-2559 -LRB- denotes (
T1765 2559-2563 NN denotes GREs
T1766 2563-2564 -RRB- denotes )
T1767 2565-2567 IN denotes in
T1768 2568-2571 DT denotes the
T1769 2572-2580 NN denotes promoter
T1770 2581-2588 NN denotes regions
T1771 2589-2591 IN denotes of
T1772 2592-2609 JJ denotes steroid-sensitive
T1773 2610-2615 NN denotes genes
T1774 2617-2630 RB denotes Alternatively
T1775 2630-2631 -COMMA- denotes ,
T1776 2632-2641 VB denotes activated
T1777 2642-2644 NN denotes GR
T1778 2645-2654 VB denotes interacts
T1779 2655-2659 IN denotes with
T1780 2660-2671 NN denotes coactivator
T1781 2672-2681 NN denotes molecules
T1782 2682-2684 TO denotes to
T1783 2685-2693 VB denotes suppress
T1784 2694-2697 DT denotes the
T1785 2698-2708 NN denotes expression
T1786 2709-2711 IN denotes of
T1787 2712-2724 JJ denotes inflammatory
T1788 2725-2730 NN denotes genes
T1789 2731-2733 IN denotes by
T1790 2734-2744 VB denotes inhibiting
T1791 2745-2748 DT denotes the
T1792 2749-2755 NN denotes action
T1793 2756-2758 IN denotes of
T1794 2759-2774 JJ denotes proinflammatory
T1795 2775-2788 NN denotes transcription
T1796 2789-2796 NN denotes factors
T1797 2797-2801 JJ denotes such
T1798 2802-2804 IN denotes as
T1799 2805-2812 JJ denotes nuclear
T1800 2813-2822 NN denotes factor-κB
T1801 2823-2824 -LRB- denotes (
T1802 2824-2829 NN denotes NF-κB
T1803 2829-2830 -RRB- denotes )
T1804 2831-2838 IN denotes through
T1805 2839-2842 DT denotes the
T1806 2843-2854 NN denotes recruitment
T1807 2855-2857 IN denotes of
T1808 2858-2870 NN denotes co-repressor
T1809 2871-2880 NN denotes molecules
T1810 2881-2885 JJ denotes such
T1811 2886-2888 IN denotes as
T1812 2889-2896 NN denotes histone
T1813 2897-2910 NN denotes deacetylase-2
T1814 2911-2912 -LRB- denotes [
T1815 2912-2914 CD denotes 17
T1816 2914-2915 -RRB- denotes ]
T1817 2915-2916 -COMMA- denotes ,
T1818 2916-2917 -LRB- denotes [
T1819 2917-2919 CD denotes 18
T1820 2919-2920 -RRB- denotes ]
T1821 2922-2929 JJ denotes Nuclear
T1822 2930-2942 NN denotes localisation
T1823 2943-2946 CC denotes and
T1824 2947-2956 NN denotes retention
T1825 2957-2959 IN denotes of
T1826 2960-2962 NN denotes GR
T1827 2963-2965 VB denotes is
T1828 2966-2974 VB denotes mediated
T1829 2975-2982 IN denotes through
T1830 2983-2986 DT denotes the
T1831 2987-2994 JJ denotes nuclear
T1832 2995-3007 NN denotes localisation
T1833 3008-3017 NN denotes sequences
T1834 3018-3021 NN denotes NL1
T1835 3022-3025 CC denotes and
T1836 3026-3029 NN denotes NL2
T1837 3030-3031 -LRB- denotes [
T1838 3031-3033 CD denotes 19
T1839 3033-3034 -RRB- denotes ]
T1840 3034-3035 -COMMA- denotes ,
T1841 3036-3038 IN denotes by
T1842 3039-3046 JJ denotes nuclear
T1843 3047-3056 NN denotes retention
T1844 3057-3064 NN denotes signals
T1845 3065-3066 -LRB- denotes [
T1846 3066-3068 CD denotes 20
T1847 3068-3069 -RRB- denotes ]
T1848 3069-3070 -COMMA- denotes ,
T1849 3071-3074 CC denotes and
T1850 3075-3077 IN denotes by
T1851 3078-3085 NN denotes control
T1852 3086-3088 IN denotes of
T1853 3089-3096 JJ denotes nuclear
T1854 3097-3103 NN denotes export
T1855 3104-3107 IN denotes via
T1856 3108-3109 DT denotes a
T1857 3110-3121 JJ denotes chromosomal
T1858 3122-3128 NN denotes region
T1859 3129-3140 NN denotes maintenance
T1860 3141-3142 CD denotes 1
T1861 3143-3144 -LRB- denotes (
T1862 3144-3149 NN denotes CRM-1
T1863 3149-3150 -RRB- denotes )
T1864 3151-3160 JJ denotes dependent
T1865 3161-3168 NN denotes pathway
T1866 3169-3170 -LRB- denotes [
T1867 3170-3172 CD denotes 21
T1868 3172-3173 -RRB- denotes ]
T1869 3175-3178 NN denotes NL1
T1870 3178-3179 -COMMA- denotes ,
T1871 3180-3185 WDT denotes which
T1872 3186-3188 VB denotes is
T1873 3189-3196 JJ denotes similar
T1874 3197-3199 TO denotes to
T1875 3200-3203 DT denotes the
T1876 3204-3208 NN denotes SV40
T1877 3209-3212 NN denotes NLS
T1878 3212-3213 -COMMA- denotes ,
T1879 3214-3219 VB denotes binds
T1880 3220-3222 TO denotes to
T1881 3223-3233 JJ denotes importin-α
T1882 3234-3235 -LRB- denotes [
T1883 3235-3237 CD denotes 22
T1884 3237-3238 -RRB- denotes ]
T1885 3240-3243 NN denotes NL1
T1886 3244-3246 VB denotes is
T1887 3247-3256 VB denotes activated
T1888 3257-3261 CC denotes both
T1889 3262-3264 IN denotes by
T1890 3265-3279 NN denotes glucocorticoid
T1891 3280-3288 NN denotes agonists
T1892 3289-3293 JJ denotes such
T1893 3294-3296 IN denotes as
T1894 3297-3310 NN denotes dexamethasone
T1895 3311-3314 CC denotes and
T1896 3315-3326 NN denotes fluticasone
T1897 3327-3337 NN denotes propionate
T1898 3338-3339 -LRB- denotes (
T1899 3339-3341 NN denotes FP
T1900 3341-3342 -RRB- denotes )
T1901 3343-3346 CC denotes and
T1902 3347-3349 IN denotes by
T1903 3350-3364 NN denotes glucocorticoid
T1904 3365-3376 NN denotes antagonists
T1905 3377-3381 JJ denotes such
T1906 3382-3384 IN denotes as
T1907 3385-3397 NN denotes mifepristone
T1908 3398-3399 -LRB- denotes (
T1909 3399-3404 NN denotes RU486
T1910 3404-3405 -RRB- denotes )
T1911 3406-3407 -LRB- denotes [
T1912 3407-3409 CD denotes 23
T1913 3409-3410 -RRB- denotes ]
T1914 3412-3415 NN denotes NL1
T1915 3416-3419 MD denotes can
T1916 3420-3422 VB denotes be
T1917 3423-3430 VB denotes mutated
T1918 3430-3431 -COMMA- denotes ,
T1919 3432-3435 CC denotes and
T1920 3436-3439 DT denotes the
T1921 3440-3449 VB denotes resulting
T1922 3450-3452 NN denotes GR
T1923 3453-3458 RB denotes still
T1924 3459-3471 VB denotes translocates
T1925 3472-3474 TO denotes to
T1926 3475-3478 DT denotes the
T1927 3479-3486 NN denotes nucleus
T1928 3487-3489 IN denotes in
T1929 3490-3498 NN denotes response
T1930 3499-3501 TO denotes to
T1931 3502-3509 NN denotes ligands
T1932 3509-3510 -COMMA- denotes ,
T1933 3511-3514 CC denotes but
T1934 3515-3518 IN denotes via
T1935 3519-3530 NN denotes interaction
T1936 3531-3535 IN denotes with
T1937 3536-3544 NN denotes importin
T1938 3545-3546 CD denotes 7
T1939 3546-3547 -COMMA- denotes ,
T1940 3548-3550 DT denotes an
T1941 3551-3556 NN denotes event
T1942 3557-3561 WDT denotes that
T1943 3562-3570 VB denotes requires
T1944 3571-3573 DT denotes an
T1945 3574-3580 JJ denotes as-yet
T1946 3581-3588 JJ denotes unknown
T1947 3589-3598 NN denotes component
T1948 3599-3600 -LRB- denotes [
T1949 3600-3602 CD denotes 23
T1950 3602-3603 -RRB- denotes ]
T1951 3605-3608 NN denotes NL2
T1952 3609-3611 VB denotes is
T1953 3612-3618 RB denotes poorly
T1954 3619-3626 VB denotes defined
T1955 3626-3627 -COMMA- denotes ,
T1956 3628-3636 VB denotes residing
T1957 3637-3639 IN denotes in
T1958 3640-3643 DT denotes the
T1959 3644-3658 JJ denotes ligand-binding
T1960 3659-3665 NN denotes domain
T1961 3665-3666 -COMMA- denotes ,
T1962 3667-3670 CC denotes and
T1963 3671-3675 RB denotes much
T1964 3676-3680 JJ denotes less
T1965 3681-3683 VB denotes is
T1966 3684-3689 VB denotes known
T1967 3690-3695 IN denotes about
T1968 3696-3699 PRP-DOLLAR- denotes its
T1969 3700-3709 NN denotes mechanism
T1970 3710-3712 IN denotes of
T1971 3713-3715 NN denotes GR
T1972 3716-3722 NN denotes import
T1973 3723-3724 -LRB- denotes [
T1974 3724-3726 CD denotes 24
T1975 3726-3727 -RRB- denotes ]
T1976 3729-3730 DT denotes A
T1977 3731-3738 NN denotes variety
T1978 3739-3741 IN denotes of
T1979 3742-3747 JJ denotes other
T1980 3748-3755 NN denotes factors
T1981 3756-3759 VB denotes are
T1982 3760-3764 RB denotes also
T1983 3765-3774 JJ denotes important
T1984 3775-3778 IN denotes for
T1985 3779-3782 DT denotes the
T1986 3783-3793 NN denotes regulation
T1987 3794-3796 IN denotes of
T1988 3797-3799 NN denotes GR
T1989 3800-3810 NN denotes activation
T1990 3811-3814 CC denotes and
T1991 3815-3822 JJ denotes nuclear
T1992 3823-3829 NN denotes import
T1993 3830-3839 VB denotes including
T1994 3840-3850 NN denotes chaperones
T1995 3851-3855 JJ denotes such
T1996 3856-3858 IN denotes as
T1997 3859-3864 NN denotes Hsp90
T1998 3865-3868 CC denotes and
T1999 3869-3874 JJ denotes other
T2000 3875-3888 NN denotes immunophilins
T2001 3889-3890 -LRB- denotes [
T2002 3890-3892 CD denotes 24
T2003 3892-3893 -RRB- denotes ]
T2004 3893-3894 CD denotes –
T2005 3894-3895 -LRB- denotes [
T2006 3895-3897 CD denotes 26
T2007 3897-3898 -RRB- denotes ]
T2008 3899-3902 CC denotes and
T2009 3903-3916 JJ denotes FK506-binding
T2010 3917-3925 NN denotes proteins
T2011 3926-3930 WDT denotes that
T2012 3931-3934 MD denotes may
T2013 3935-3937 VB denotes be
T2014 3938-3944 VB denotes linked
T2015 3945-3947 TO denotes to
T2016 3948-3954 NN denotes dynein
T2017 3955-3961 CC denotes and/or
T2018 3962-3976 JJ denotes peptidylprolyl
T2019 3977-3986 NN denotes isomerase
T2020 3987-3988 -LRB- denotes [
T2021 3988-3990 CD denotes 27
T2022 3990-3991 -RRB- denotes ]
T2023 3991-3992 -COMMA- denotes ,
T2024 3992-3993 -LRB- denotes [
T2025 3993-3995 CD denotes 28
T2026 3995-3996 -RRB- denotes ]
T2027 3998-4005 RB denotes However
T2028 4005-4006 -COMMA- denotes ,
T2029 4007-4010 DT denotes the
T2030 4011-4020 JJ denotes molecular
T2031 4021-4026 NN denotes basis
T2032 4027-4030 IN denotes for
T2033 4031-4034 DT denotes the
T2034 4035-4045 NN denotes inhibition
T2035 4046-4048 IN denotes of
T2036 4049-4052 NN denotes Th2
T2037 4053-4062 NN denotes cytokines
T2038 4063-4065 IN denotes by
T2039 4066-4081 NN denotes corticosteroids
T2040 4082-4084 VB denotes is
T2041 4085-4088 RB denotes not
T2042 4089-4093 RB denotes well
T2043 4094-4104 VB denotes understood
T2044 4104-4105 -COMMA- denotes ,
T2045 4106-4113 IN denotes because
T2046 4114-4117 DT denotes the
T2047 4118-4123 NN denotes genes
T2048 4124-4132 VB denotes encoding
T2049 4133-4137 NN denotes IL-4
T2050 4137-4138 -COMMA- denotes ,
T2051 4139-4143 NN denotes IL-5
T2052 4143-4144 -COMMA- denotes ,
T2053 4145-4148 CC denotes and
T2054 4149-4154 NN denotes IL-13
T2055 4155-4157 VB denotes do
T2056 4158-4161 RB denotes not
T2057 4162-4166 VB denotes have
T2058 4167-4170 DT denotes any
T2059 4171-4183 JJ denotes recognisable
T2060 4184-4187 NN denotes GRE
T2061 4188-4196 NN denotes sequence
T2062 4197-4198 -LRB- denotes [
T2063 4198-4200 CD denotes 29
T2064 4200-4201 -RRB- denotes ]
T2065 4202-4205 CC denotes and
T2066 4206-4209 VB denotes are
T2067 4210-4214 RB denotes only
T2068 4215-4221 RB denotes partly
T2069 4222-4231 VB denotes regulated
T2070 4232-4234 IN denotes by
T2071 4235-4240 NN denotes NF-κB
T2072 4241-4243 IN denotes in
T2073 4244-4249 JJ denotes human
T2074 4250-4255 NN denotes cells
T2075 4256-4257 -LRB- denotes [
T2076 4257-4259 CD denotes 30
T2077 4259-4260 -RRB- denotes ]
T2078 4260-4261 CD denotes –
T2079 4261-4262 -LRB- denotes [
T2080 4262-4264 CD denotes 32
T2081 4264-4265 -RRB- denotes ]
T2082 4267-4272 VB denotes Using
T2083 4273-4287 NN denotes overexpression
T2084 4288-4291 CC denotes and
T2085 4292-4304 NN denotes CAT-reporter
T2086 4305-4310 NN denotes genes
T2087 4310-4311 -COMMA- denotes ,
T2088 4312-4320 NNP denotes Lavender
T2089 4321-4324 CC denotes and
T2090 4325-4335 NN denotes colleagues
T2091 4336-4337 -LRB- denotes [
T2092 4337-4339 CD denotes 33
T2093 4339-4340 -RRB- denotes ]
T2094 4341-4345 VB denotes have
T2095 4346-4351 VB denotes shown
T2096 4352-4356 IN denotes that
T2097 4357-4359 NN denotes GR
T2098 4360-4367 VB denotes reduced
T2099 4368-4383 JJ denotes GATA-3-mediated
T2100 4384-4388 NN denotes IL-5
T2101 4389-4392 CC denotes and
T2102 4393-4396 CD denotes -13
T2103 4397-4405 NN denotes promoter
T2104 4406-4414 NN denotes activity
T2105 4415-4417 IN denotes in
T2106 4418-4423 JJ denotes human
T2107 4424-4428 JJ denotes CD4+
T2108 4429-4430 NN denotes T
T2109 4431-4436 NN denotes cells
T2110 4438-4441 DT denotes The
T2111 4442-4449 NN denotes authors
T2112 4450-4460 VB denotes postulated
T2113 4461-4465 IN denotes that
T2114 4466-4471 JJ denotes local
T2115 4472-4483 NN denotes recruitment
T2116 4484-4486 IN denotes of
T2117 4487-4489 NN denotes GR
T2118 4490-4493 MD denotes may
T2119 4494-4499 VB denotes alter
T2120 4500-4503 DT denotes the
T2121 4504-4511 NN denotes ability
T2122 4512-4514 IN denotes of
T2123 4515-4521 NN denotes GATA-3
T2124 4522-4528 CC denotes either
T2125 4529-4531 TO denotes to
T2126 4532-4536 VB denotes bind
T2127 4537-4539 TO denotes to
T2128 4540-4543 PRP-DOLLAR- denotes its
T2129 4544-4550 NN denotes target
T2130 4551-4555 NN denotes site
T2131 4555-4556 -COMMA- denotes ,
T2132 4557-4559 TO denotes to
T2133 4560-4565 VB denotes cause
T2134 4566-4581 JJ denotes transcriptional
T2135 4582-4595 NN denotes up-regulation
T2136 4595-4596 -COMMA- denotes ,
T2137 4597-4599 CC denotes or
T2138 4600-4602 TO denotes to
T2139 4603-4611 VB denotes maintain
T2140 4612-4614 DT denotes an
T2141 4615-4626 NN denotes environment
T2142 4627-4631 WDT denotes that
T2143 4632-4634 VB denotes is
T2144 4635-4645 JJ denotes permissive
T2145 4646-4649 IN denotes for
T2146 4650-4663 NN denotes transcription
T2147 4665-4667 PRP denotes We
T2148 4668-4677 RB denotes therefore
T2149 4678-4690 VB denotes investigated
T2150 4691-4694 DT denotes the
T2151 4695-4702 NN denotes effects
T2152 4703-4705 IN denotes of
T2153 4706-4707 DT denotes a
T2154 4708-4717 JJ denotes synthetic
T2155 4718-4732 NN denotes corticosteroid
T2156 4732-4733 -COMMA- denotes ,
T2157 4734-4736 NN denotes FP
T2158 4736-4737 -COMMA- denotes ,
T2159 4738-4740 IN denotes on
T2160 4741-4747 NN denotes GATA-3
T2161 4748-4763 NN denotes phosphorylation
T2162 4764-4767 CC denotes and
T2163 4768-4775 JJ denotes nuclear
T2164 4776-4789 NN denotes translocation
T2165 4790-4792 IN denotes in
T2166 4793-4794 DT denotes a
T2167 4795-4796 NN denotes T
T2168 4797-4807 NN denotes lymphocyte
T2169 4808-4812 NN denotes cell
T2170 4813-4817 NN denotes line
T2171 4818-4819 -LRB- denotes (
T2172 4819-4825 NN denotes HuT-78
T2173 4825-4826 -RRB- denotes )
T2174 4827-4830 CC denotes and
T2175 4831-4833 IN denotes in
T2176 4834-4844 JJ denotes peripheral
T2177 4845-4850 NN denotes blood
T2178 4851-4862 JJ denotes mononuclear
T2179 4863-4868 NN denotes cells
T2180 4869-4878 VB denotes activated
T2181 4879-4881 IN denotes by
T2182 4882-4890 JJ denotes anti-CD3
T2183 4891-4894 CC denotes and
T2184 4895-4904 JJ denotes anti-CD28
T2185 4905-4915 NN denotes antibodies
T2186 4916-4918 FW denotes in
T2187 4919-4924 FW denotes vitro
T2188 4926-4928 PRP denotes We
T2189 4929-4933 RB denotes also
T2190 4934-4941 VB denotes studied
T2191 4942-4945 DT denotes the
T2192 4946-4953 NN denotes effects
T2193 4954-4956 IN denotes of
T2194 4957-4964 VB denotes inhaled
T2195 4965-4976 NN denotes fluticasone
T2196 4977-4984 NN denotes therapy
T2197 4985-4987 IN denotes on
T2198 4988-4994 NN denotes GATA-3
T2199 4995-5006 JJ denotes subcellular
T2200 5007-5019 NN denotes localization
T2201 5020-5022 IN denotes in
T2202 5023-5033 JJ denotes peripheral
T2203 5034-5039 NN denotes blood
T2204 5040-5051 JJ denotes mononuclear
T2205 5052-5057 NN denotes cells
T2206 5058-5059 -LRB- denotes (
T2207 5059-5064 NN denotes PBMCs
T2208 5064-5065 -RRB- denotes )
T2209 5066-5070 IN denotes from
T2210 5071-5079 NN denotes patients
T2211 5080-5084 IN denotes with
T2212 5085-5091 NN denotes asthma
R1046 T1321 T1322 arg1Of Inflammation,in
R1047 T1321 T1334 arg1Of Inflammation,is
R1048 T1321 T1335 arg2Of Inflammation,mediated
R1049 T1324 T1322 arg2Of diseases,in
R1050 T1324 T1323 arg1Of diseases,allergic
R1051 T1324 T1326 arg1Of diseases,as
R1052 T1326 T1325 arg1Of as,such
R1053 T1327 T1328 arg1Of asthma,","
R1054 T1328 T1331 arg1Of ",",and
R1055 T1329 T1328 arg2Of rhinitis,","
R1056 T1331 T1326 arg2Of and,as
R1057 T1331 T1330 arg1Of and,","
R1058 T1333 T1331 arg2Of dermatitis,and
R1059 T1333 T1332 arg1Of dermatitis,atopic
R1060 T1335 T1334 arg2Of mediated,is
R1061 T1335 T1336 arg1Of mediated,via
R1062 T1337 T1336 arg2Of expression,via
R1063 T1337 T1338 arg1Of expression,of
R1064 T1340 T1339 arg1Of cytokines,the
R1065 T1341 T1342 arg1Of interleukin,(
R1066 T1341 T1345 arg1Of interleukin,-4
R1067 T1341 T1346 arg1Of interleukin,","
R1068 T1343 T1342 arg2Of IL,(
R1069 T1344 T1342 arg3Of ),(
R1070 T1346 T1349 arg1Of ",",and
R1071 T1347 T1346 arg2Of IL-5,","
R1072 T1349 T1338 arg2Of and,of
R1073 T1349 T1340 arg1Of and,cytokines
R1074 T1349 T1348 arg1Of and,","
R1075 T1349 T1351 arg1Of and,from
R1076 T1350 T1349 arg2Of IL-13,and
R1077 T1355 T1354 arg2Of Th2,(
R1078 T1356 T1354 arg3Of ),(
R1079 T1357 T1351 arg2Of cells,from
R1080 T1357 T1352 arg1Of cells,T
R1081 T1357 T1353 arg1Of cells,helper-2
R1082 T1357 T1354 arg1Of cells,(
R1083 T1358 T1359 arg1Of IL-4,and
R1084 T1359 T1361 arg1Of and,regulate
R1085 T1360 T1359 arg2Of IL-13,and
R1086 T1361 T1370 arg1Of regulate,whereas
R1087 T1363 T1361 arg2Of expression,regulate
R1088 T1363 T1362 arg1Of expression,the
R1089 T1363 T1364 arg1Of expression,of
R1090 T1363 T1366 arg1Of expression,from
R1091 T1365 T1364 arg2Of IgE,of
R1092 T1368 T1366 arg2Of lymphocytes,from
R1093 T1368 T1367 arg1Of lymphocytes,B
R1094 T1370 T1369 arg1Of whereas,","
R1095 T1371 T1372 arg1Of IL-5,plays
R1096 T1372 T1370 arg2Of plays,whereas
R1097 T1372 T1376 arg1Of plays,in
R1098 T1375 T1372 arg2Of role,plays
R1099 T1375 T1373 arg1Of role,a
R1100 T1375 T1374 arg1Of role,key
R1101 T1378 T1376 arg2Of inflammation,in
R1102 T1378 T1377 arg1Of inflammation,eosinophilic
R1103 T1378 T1379 arg1Of inflammation,[
R1104 T1380 T1379 arg2Of 1,[
R1105 T1381 T1379 arg3Of ],[
R1106 T1383 T1382 arg1Of cytokines,Th2
R1107 T1383 T1384 arg1Of cytokines,are
R1108 T1383 T1385 arg2Of cytokines,regulated
R1109 T1385 T1384 arg2Of regulated,are
R1110 T1392 T1385 arg1Of GATA-3,regulated
R1111 T1392 T1386 arg2Of GATA-3,by
R1112 T1392 T1387 arg1Of GATA-3,the
R1113 T1392 T1388 arg1Of GATA-3,zinc
R1114 T1392 T1389 arg1Of GATA-3,finger
R1115 T1392 T1390 arg1Of GATA-3,transcription
R1116 T1392 T1391 arg1Of GATA-3,factor
R1117 T1392 T1393 arg1Of GATA-3,","
R1118 T1392 T1394 arg1Of GATA-3,which
R1119 T1392 T1395 arg1Of GATA-3,is
R1120 T1392 T1397 arg2Of GATA-3,expressed
R1121 T1397 T1395 arg2Of expressed,is
R1122 T1397 T1396 arg1Of expressed,predominantly
R1123 T1397 T1398 arg1Of expressed,in
R1124 T1397 T1404 arg1Of expressed,","
R1125 T1397 T1405 arg1Of expressed,[
R1126 T1400 T1398 arg2Of cells,in
R1127 T1400 T1399 arg1Of cells,Th2
R1128 T1400 T1401 arg1Of cells,[
R1129 T1402 T1401 arg2Of 2,[
R1130 T1403 T1401 arg3Of ],[
R1131 T1406 T1405 arg2Of 3,[
R1132 T1407 T1405 arg3Of ],[
R1133 T1408 T1409 arg1Of GATA-3,determines
R1134 T1408 T1415 arg1Of GATA-3,activates
R1135 T1409 T1413 arg1Of determines,and
R1136 T1412 T1409 arg2Of differentiation,determines
R1137 T1412 T1410 arg1Of differentiation,Th2
R1138 T1412 T1411 arg1Of differentiation,cell
R1139 T1413 T1432 arg1Of and,[
R1140 T1415 T1413 arg2Of activates,and
R1141 T1415 T1414 arg1Of activates,selectively
R1142 T1415 T1425 arg1Of activates,through
R1143 T1417 T1415 arg2Of promoters,activates
R1144 T1417 T1416 arg1Of promoters,the
R1145 T1417 T1418 arg1Of promoters,of
R1146 T1419 T1420 arg1Of IL-4,","
R1147 T1420 T1423 arg1Of ",",and
R1148 T1421 T1420 arg2Of IL-5,","
R1149 T1423 T1418 arg2Of and,of
R1150 T1423 T1422 arg1Of and,","
R1151 T1424 T1423 arg2Of IL-13,and
R1152 T1426 T1425 arg2Of chromatin,through
R1153 T1426 T1427 arg1Of chromatin,remodelling
R1154 T1429 T1428 arg2Of 4,[
R1155 T1430 T1428 arg3Of ],[
R1156 T1431 T1427 arg2Of –,remodelling
R1157 T1431 T1428 arg1Of –,[
R1158 T1433 T1432 arg2Of 7,[
R1159 T1434 T1432 arg3Of ],[
R1160 T1437 T1435 arg1Of role,The
R1161 T1437 T1436 arg1Of role,key
R1162 T1437 T1438 arg1Of role,of
R1163 T1437 T1440 arg1Of role,in
R1164 T1437 T1444 arg1Of role,has
R1165 T1437 T1445 arg1Of role,been
R1166 T1437 T1446 arg2Of role,demonstrated
R1167 T1439 T1438 arg2Of GATA-3,of
R1168 T1443 T1440 arg2Of inflammation,in
R1169 T1443 T1441 arg1Of inflammation,allergic
R1170 T1443 T1442 arg1Of inflammation,airway
R1171 T1446 T1444 arg2Of demonstrated,has
R1172 T1446 T1445 arg2Of demonstrated,been
R1173 T1446 T1447 arg1Of demonstrated,in
R1174 T1446 T1456 arg1Of demonstrated,in
R1175 T1446 T1465 arg1Of demonstrated,by
R1176 T1446 T1476 arg1Of demonstrated,","
R1177 T1446 T1477 arg1Of demonstrated,[
R1178 T1448 T1447 arg2Of mice,in
R1179 T1452 T1446 arg1Of release,demonstrated
R1180 T1452 T1449 arg2Of release,by
R1181 T1452 T1450 arg1Of release,the
R1182 T1452 T1451 arg2Of release,reduced
R1183 T1452 T1453 arg1Of release,of
R1184 T1455 T1453 arg2Of cytokines,of
R1185 T1455 T1454 arg1Of cytokines,Th2
R1186 T1456 T1464 arg1Of in,and
R1187 T1457 T1456 arg2Of animals,in
R1188 T1457 T1458 arg2Of animals,treated
R1189 T1458 T1459 arg1Of treated,with
R1190 T1461 T1459 arg2Of mutants,with
R1191 T1461 T1460 arg1Of mutants,dominant-negative
R1192 T1461 T1462 arg1Of mutants,of
R1193 T1463 T1462 arg2Of GATA-3,of
R1194 T1465 T1464 arg2Of by,and
R1195 T1467 T1465 arg2Of application,by
R1196 T1467 T1466 arg1Of application,local
R1197 T1467 T1468 arg1Of application,of
R1198 T1467 T1471 arg1Of application,to
R1199 T1470 T1468 arg2Of oligonucleotides,of
R1200 T1470 T1469 arg1Of oligonucleotides,antisense
R1201 T1472 T1471 arg2Of GATA-3,to
R1202 T1472 T1473 arg1Of GATA-3,[
R1203 T1474 T1473 arg2Of 8,[
R1204 T1475 T1473 arg3Of ],[
R1205 T1478 T1477 arg2Of 9,[
R1206 T1479 T1477 arg3Of ],[
R1207 T1483 T1482 arg1Of knock-out,conditional
R1208 T1483 T1484 arg1Of knock-out,of
R1209 T1483 T1488 arg1Of knock-out,in
R1210 T1483 T1490 arg1Of knock-out,reduces
R1211 T1487 T1484 arg2Of gene,of
R1212 T1487 T1485 arg1Of gene,the
R1213 T1487 T1486 arg1Of gene,Gata3
R1214 T1489 T1488 arg2Of mice,in
R1215 T1490 T1480 arg1Of reduces,Furthermore
R1216 T1490 T1481 arg1Of reduces,","
R1217 T1490 T1504 arg1Of reduces,and
R1218 T1491 T1490 arg2Of expression,reduces
R1219 T1491 T1492 arg1Of expression,of
R1220 T1491 T1496 arg1Of expression,vitro
R1221 T1491 T1499 arg1Of expression,vivo
R1222 T1491 T1500 arg1Of expression,[
R1223 T1494 T1492 arg2Of cytokines,of
R1224 T1494 T1493 arg1Of cytokines,Th2
R1225 T1496 T1495 arg1Of vitro,in
R1226 T1496 T1497 arg1Of vitro,and
R1227 T1499 T1497 arg2Of vivo,and
R1228 T1499 T1498 arg1Of vivo,in
R1229 T1501 T1500 arg2Of 10,[
R1230 T1502 T1500 arg3Of ],[
R1231 T1504 T1503 arg1Of and,","
R1232 T1506 T1505 arg1Of results,similar
R1233 T1506 T1507 arg1Of results,have
R1234 T1506 T1508 arg1Of results,been
R1235 T1506 T1509 arg2Of results,reported
R1236 T1509 T1504 arg2Of reported,and
R1237 T1509 T1507 arg2Of reported,have
R1238 T1509 T1508 arg2Of reported,been
R1239 T1509 T1510 arg1Of reported,in
R1240 T1514 T1510 arg2Of lymphocytes,in
R1241 T1514 T1511 arg2Of lymphocytes,isolated
R1242 T1514 T1512 arg1Of lymphocytes,murine
R1243 T1514 T1513 arg1Of lymphocytes,CD4+
R1244 T1514 T1515 arg1Of lymphocytes,[
R1245 T1516 T1515 arg2Of 11,[
R1246 T1517 T1515 arg3Of ],[
R1247 T1520 T1521 arg1Of knockdown,of
R1248 T1520 T1530 arg1Of knockdown,results
R1249 T1523 T1521 arg2Of expression,of
R1250 T1523 T1522 arg1Of expression,GATA-3
R1251 T1523 T1524 arg1Of expression,using
R1252 T1524 T1526 arg1Of using,in
R1253 T1525 T1524 arg2Of siRNA,using
R1254 T1529 T1526 arg2Of cells,in
R1255 T1529 T1527 arg1Of cells,human
R1256 T1529 T1528 arg1Of cells,T
R1257 T1530 T1518 arg1Of results,Finally
R1258 T1530 T1519 arg1Of results,","
R1259 T1530 T1531 arg1Of results,in
R1260 T1530 T1538 arg1Of results,[
R1261 T1532 T1531 arg2Of loss,in
R1262 T1532 T1533 arg1Of loss,of
R1263 T1537 T1533 arg2Of expression,of
R1264 T1537 T1534 arg1Of expression,anti-CD3/CD28-mediated
R1265 T1537 T1535 arg1Of expression,Th2
R1266 T1537 T1536 arg1Of expression,cytokine
R1267 T1539 T1538 arg2Of 12,[
R1268 T1540 T1538 arg3Of ],[
R1269 T1542 T1541 arg2Of order,In
R1270 T1542 T1543 arg1Of order,for
R1271 T1544 T1543 arg2Of GATA-3,for
R1272 T1544 T1546 arg1Of GATA-3,regulate
R1273 T1546 T1543 arg3Of regulate,for
R1274 T1546 T1545 arg1Of regulate,to
R1275 T1548 T1546 arg2Of expression,regulate
R1276 T1548 T1547 arg1Of expression,gene
R1277 T1550 T1551 arg1Of it,must
R1278 T1550 T1552 arg1Of it,translocate
R1279 T1552 T1541 arg1Of translocate,In
R1280 T1552 T1549 arg1Of translocate,","
R1281 T1552 T1551 arg2Of translocate,must
R1282 T1552 T1553 arg1Of translocate,from
R1283 T1555 T1553 arg2Of cytoplasm,from
R1284 T1555 T1554 arg1Of cytoplasm,the
R1285 T1555 T1556 arg1Of cytoplasm,into
R1286 T1558 T1556 arg2Of nucleus,into
R1287 T1558 T1557 arg1Of nucleus,the
R1288 T1558 T1559 modOf nucleus,to
R1289 T1560 T1559 arg1Of access,to
R1290 T1563 T1560 arg2Of genes,access
R1291 T1563 T1561 arg1Of genes,its
R1292 T1563 T1562 arg1Of genes,target
R1293 T1566 T1564 arg2Of expression,Enhanced
R1294 T1566 T1565 arg1Of expression,nuclear
R1295 T1566 T1567 arg1Of expression,of
R1296 T1566 T1574 arg1Of expression,was
R1297 T1566 T1576 arg2Of expression,demonstrated
R1298 T1566 T1585 arg1Of expression,was
R1299 T1566 T1587 arg2Of expression,confirmed
R1300 T1568 T1567 arg2Of GATA-3,of
R1301 T1568 T1569 arg1Of GATA-3,following
R1302 T1573 T1569 arg2Of activation,following
R1303 T1573 T1570 arg1Of activation,T
R1304 T1573 T1571 arg1Of activation,cell
R1305 T1573 T1572 arg1Of activation,receptor
R1306 T1576 T1574 arg2Of demonstrated,was
R1307 T1576 T1575 arg1Of demonstrated,first
R1308 T1576 T1577 arg1Of demonstrated,in
R1309 T1576 T1581 arg1Of demonstrated,[
R1310 T1576 T1584 arg1Of demonstrated,and
R1311 T1580 T1577 arg2Of cells,in
R1312 T1580 T1578 arg1Of cells,murine
R1313 T1580 T1579 arg1Of cells,T
R1314 T1582 T1581 arg2Of 13,[
R1315 T1583 T1581 arg3Of ],[
R1316 T1587 T1584 arg2Of confirmed,and
R1317 T1587 T1585 arg2Of confirmed,was
R1318 T1587 T1586 arg1Of confirmed,recently
R1319 T1587 T1588 arg1Of confirmed,in
R1320 T1587 T1592 arg1Of confirmed,following
R1321 T1591 T1588 arg2Of cells,in
R1322 T1591 T1589 arg1Of cells,human
R1323 T1591 T1590 arg1Of cells,T
R1324 T1595 T1593 arg1Of receptor,T
R1325 T1595 T1594 arg1Of receptor,cell
R1326 T1595 T1596 arg1Of receptor,and
R1327 T1596 T1592 arg2Of and,following
R1328 T1598 T1596 arg2Of stimulation,and
R1329 T1598 T1597 arg1Of stimulation,co-receptor
R1330 T1598 T1599 arg1Of stimulation,[
R1331 T1600 T1599 arg2Of 12,[
R1332 T1601 T1599 arg3Of ],[
R1333 T1602 T1603 arg1Of GATA-3,contains
R1334 T1602 T1613 arg1Of GATA-3,is
R1335 T1602 T1614 arg2Of GATA-3,transported
R1336 T1603 T1609 arg1Of contains,[
R1337 T1603 T1612 arg1Of contains,and
R1338 T1608 T1603 arg2Of signal,contains
R1339 T1608 T1604 arg1Of signal,a
R1340 T1608 T1605 arg1Of signal,classical
R1341 T1608 T1606 arg1Of signal,nuclear
R1342 T1608 T1607 arg1Of signal,import
R1343 T1610 T1609 arg2Of 14,[
R1344 T1611 T1609 arg3Of ],[
R1345 T1614 T1612 arg2Of transported,and
R1346 T1614 T1613 arg2Of transported,is
R1347 T1614 T1615 arg1Of transported,into
R1348 T1614 T1618 arg1Of transported,by
R1349 T1614 T1630 arg1Of transported,[
R1350 T1617 T1615 arg2Of nucleus,into
R1351 T1617 T1616 arg1Of nucleus,the
R1352 T1623 T1618 arg2Of importin-α,by
R1353 T1623 T1619 arg1Of importin-α,the
R1354 T1623 T1620 arg1Of importin-α,nuclear
R1355 T1623 T1621 arg1Of importin-α,import
R1356 T1623 T1622 arg1Of importin-α,protein
R1357 T1623 T1624 arg1Of importin-α,(
R1358 T1626 T1624 arg2Of known,(
R1359 T1626 T1625 arg1Of known,also
R1360 T1626 T1627 arg1Of known,as
R1361 T1628 T1627 arg2Of karyopherin-α,as
R1362 T1629 T1624 arg3Of ),(
R1363 T1631 T1630 arg2Of 12,[
R1364 T1632 T1630 arg3Of ],[
R1365 T1633 T1634 arg1Of Deletion,of
R1366 T1633 T1652 arg1Of Deletion,prevents
R1367 T1636 T1634 arg2Of region,of
R1368 T1636 T1635 arg1Of region,a
R1369 T1636 T1637 arg1Of region,encompassing
R1370 T1642 T1639 arg1Of sequence,GATA-3
R1371 T1642 T1640 arg1Of sequence,nuclear
R1372 T1642 T1641 arg1Of sequence,localisation
R1373 T1642 T1643 arg1Of sequence,(
R1374 T1644 T1643 arg2Of NLS,(
R1375 T1645 T1643 arg3Of ),(
R1376 T1646 T1637 arg2Of region,encompassing
R1377 T1646 T1638 arg1Of region,the
R1378 T1646 T1642 arg1Of region,sequence
R1379 T1646 T1647 arg1Of region,in
R1380 T1648 T1649 arg1Of murine,and
R1381 T1650 T1649 arg2Of human,and
R1382 T1651 T1647 arg2Of cells,in
R1383 T1651 T1648 arg1Of cells,murine
R1384 T1651 T1650 arg1Of cells,human
R1385 T1652 T1659 arg1Of prevents,","
R1386 T1652 T1660 arg1Of prevents,[
R1387 T1655 T1652 arg2Of localisation,prevents
R1388 T1655 T1653 arg1Of localisation,its
R1389 T1655 T1654 arg1Of localisation,nuclear
R1390 T1655 T1656 arg1Of localisation,[
R1391 T1657 T1656 arg2Of 12,[
R1392 T1658 T1656 arg3Of ],[
R1393 T1661 T1660 arg2Of 14,[
R1394 T1662 T1660 arg3Of ],[
R1395 T1664 T1663 arg1Of affinity,The
R1396 T1664 T1665 arg1Of affinity,of
R1397 T1664 T1669 arg1Of affinity,is
R1398 T1664 T1670 arg2Of affinity,regulated
R1399 T1668 T1665 arg2Of interaction,of
R1400 T1668 T1666 arg1Of interaction,the
R1401 T1668 T1667 arg1Of interaction,importin-α–NLS
R1402 T1670 T1669 arg2Of regulated,is
R1403 T1670 T1677 arg1Of regulated,and
R1404 T1672 T1670 arg1Of phosphorylation,regulated
R1405 T1672 T1671 arg2Of phosphorylation,by
R1406 T1672 T1673 arg1Of phosphorylation,[
R1407 T1674 T1673 arg2Of 15,[
R1408 T1675 T1673 arg3Of ],[
R1409 T1677 T1676 arg1Of and,","
R1410 T1678 T1679 arg1Of we,have
R1411 T1678 T1680 arg1Of we,shown
R1412 T1680 T1677 arg2Of shown,and
R1413 T1680 T1679 arg2Of shown,have
R1414 T1685 T1682 arg1Of kinase,p38
R1415 T1685 T1683 arg1Of kinase,mitogen-activated
R1416 T1685 T1684 arg1Of kinase,protein
R1417 T1685 T1686 arg1Of kinase,(
R1418 T1685 T1689 arg1Of kinase,plays
R1419 T1687 T1686 arg2Of MAPK,(
R1420 T1688 T1686 arg3Of ),(
R1421 T1689 T1680 arg2Of plays,shown
R1422 T1689 T1681 arg1Of plays,that
R1423 T1689 T1693 arg1Of plays,in
R1424 T1689 T1708 arg1Of plays,[
R1425 T1692 T1689 arg2Of role,plays
R1426 T1692 T1690 arg1Of role,a
R1427 T1692 T1691 arg1Of role,critical
R1428 T1694 T1693 arg2Of phosphorylating,in
R1429 T1694 T1696 modOf phosphorylating,to
R1430 T1695 T1694 arg2Of GATA-3,phosphorylating
R1431 T1697 T1696 arg1Of enhance,to
R1432 T1699 T1697 arg2Of interaction,enhance
R1433 T1699 T1698 arg1Of interaction,its
R1434 T1699 T1700 arg1Of interaction,with
R1435 T1699 T1705 arg1Of interaction,into
R1436 T1701 T1702 arg1Of importin-α,and
R1437 T1703 T1702 arg2Of subsequent,and
R1438 T1704 T1700 arg2Of transport,with
R1439 T1704 T1701 arg1Of transport,importin-α
R1440 T1704 T1703 arg1Of transport,subsequent
R1441 T1707 T1705 arg2Of nucleus,into
R1442 T1707 T1706 arg1Of nucleus,the
R1443 T1709 T1708 arg2Of 12,[
R1444 T1710 T1708 arg3Of ],[
R1445 T1711 T1712 arg1Of Corticosteroids,are
R1446 T1711 T1714 arg1Of Corticosteroids,effective
R1447 T1712 T1721 arg1Of are,","
R1448 T1712 T1722 arg1Of are,with
R1449 T1712 T1734 arg1Of are,[
R1450 T1714 T1712 arg2Of effective,are
R1451 T1714 T1713 arg1Of effective,highly
R1452 T1714 T1715 arg1Of effective,in
R1453 T1717 T1715 arg2Of treatment,in
R1454 T1717 T1716 arg1Of treatment,the
R1455 T1717 T1718 arg1Of treatment,of
R1456 T1720 T1718 arg2Of inflammation,of
R1457 T1720 T1719 arg1Of inflammation,allergic
R1458 T1724 T1722 arg2Of suppression,with
R1459 T1724 T1723 arg1Of suppression,marked
R1460 T1724 T1725 arg1Of suppression,of
R1461 T1724 T1728 arg1Of suppression,in
R1462 T1727 T1725 arg2Of cytokines,of
R1463 T1727 T1726 arg1Of cytokines,Th2
R1464 T1729 T1728 arg2Of airways,in
R1465 T1729 T1730 arg1Of airways,of
R1466 T1731 T1730 arg2Of patients,of
R1467 T1731 T1732 arg1Of patients,with
R1468 T1733 T1732 arg2Of asthma,with
R1469 T1735 T1734 arg2Of 16,[
R1470 T1736 T1734 arg3Of ],[
R1471 T1737 T1738 arg1Of Corticosteroids,mediate
R1472 T1738 T1742 arg1Of mediate,through
R1473 T1741 T1738 arg2Of effects,mediate
R1474 T1741 T1739 arg1Of effects,their
R1475 T1741 T1740 arg1Of effects,anti-inflammatory
R1476 T1743 T1742 arg2Of binding,through
R1477 T1743 T1744 arg1Of binding,to
R1478 T1746 T1744 arg2Of receptors,to
R1479 T1746 T1745 arg1Of receptors,glucocorticoid
R1480 T1746 T1747 arg1Of receptors,(
R1481 T1746 T1750 arg1Of receptors,","
R1482 T1746 T1751 arg1Of receptors,which
R1483 T1746 T1753 arg1Of receptors,translocate
R1484 T1748 T1747 arg2Of GRs,(
R1485 T1749 T1747 arg3Of ),(
R1486 T1753 T1752 arg1Of translocate,then
R1487 T1753 T1754 arg1Of translocate,to
R1488 T1756 T1754 arg2Of nucleus,to
R1489 T1756 T1755 arg1Of nucleus,the
R1490 T1756 T1757 arg1Of nucleus,where
R1491 T1758 T1759 arg1Of they,interact
R1492 T1759 T1757 arg2Of interact,where
R1493 T1759 T1760 arg1Of interact,with
R1494 T1763 T1760 arg2Of elements,with
R1495 T1763 T1761 arg1Of elements,glucocorticoid
R1496 T1763 T1762 arg1Of elements,response
R1497 T1763 T1764 arg1Of elements,(
R1498 T1763 T1767 arg1Of elements,in
R1499 T1765 T1764 arg2Of GREs,(
R1500 T1766 T1764 arg3Of ),(
R1501 T1770 T1767 arg2Of regions,in
R1502 T1770 T1768 arg1Of regions,the
R1503 T1770 T1769 arg1Of regions,promoter
R1504 T1770 T1771 arg1Of regions,of
R1505 T1773 T1771 arg2Of genes,of
R1506 T1773 T1772 arg1Of genes,steroid-sensitive
R1507 T1777 T1776 arg2Of GR,activated
R1508 T1777 T1778 arg1Of GR,interacts
R1509 T1777 T1783 arg1Of GR,suppress
R1510 T1777 T1790 arg1Of GR,inhibiting
R1511 T1778 T1774 arg1Of interacts,Alternatively
R1512 T1778 T1775 arg1Of interacts,","
R1513 T1778 T1779 arg1Of interacts,with
R1514 T1778 T1817 arg1Of interacts,","
R1515 T1778 T1818 arg1Of interacts,[
R1516 T1781 T1779 arg2Of molecules,with
R1517 T1781 T1780 arg1Of molecules,coactivator
R1518 T1783 T1778 arg2Of suppress,interacts
R1519 T1783 T1782 arg1Of suppress,to
R1520 T1783 T1789 arg1Of suppress,by
R1521 T1785 T1783 arg2Of expression,suppress
R1522 T1785 T1784 arg1Of expression,the
R1523 T1785 T1786 arg1Of expression,of
R1524 T1788 T1786 arg2Of genes,of
R1525 T1788 T1787 arg1Of genes,inflammatory
R1526 T1790 T1789 arg2Of inhibiting,by
R1527 T1790 T1804 arg1Of inhibiting,through
R1528 T1792 T1790 arg2Of action,inhibiting
R1529 T1792 T1791 arg1Of action,the
R1530 T1792 T1793 arg1Of action,of
R1531 T1796 T1793 arg2Of factors,of
R1532 T1796 T1794 arg1Of factors,proinflammatory
R1533 T1796 T1795 arg1Of factors,transcription
R1534 T1796 T1798 arg1Of factors,as
R1535 T1798 T1797 arg1Of as,such
R1536 T1800 T1798 arg2Of factor-κB,as
R1537 T1800 T1799 arg1Of factor-κB,nuclear
R1538 T1800 T1801 arg1Of factor-κB,(
R1539 T1802 T1801 arg2Of NF-κB,(
R1540 T1803 T1801 arg3Of ),(
R1541 T1806 T1804 arg2Of recruitment,through
R1542 T1806 T1805 arg1Of recruitment,the
R1543 T1806 T1807 arg1Of recruitment,of
R1544 T1809 T1807 arg2Of molecules,of
R1545 T1809 T1808 arg1Of molecules,co-repressor
R1546 T1809 T1811 arg1Of molecules,as
R1547 T1811 T1810 arg1Of as,such
R1548 T1813 T1811 arg2Of deacetylase-2,as
R1549 T1813 T1812 arg1Of deacetylase-2,histone
R1550 T1813 T1814 arg1Of deacetylase-2,[
R1551 T1815 T1814 arg2Of 17,[
R1552 T1816 T1814 arg3Of ],[
R1553 T1819 T1818 arg2Of 18,[
R1554 T1820 T1818 arg3Of ],[
R1555 T1822 T1821 arg1Of localisation,Nuclear
R1556 T1822 T1823 arg1Of localisation,and
R1557 T1823 T1827 arg1Of and,is
R1558 T1823 T1828 arg2Of and,mediated
R1559 T1824 T1823 arg2Of retention,and
R1560 T1824 T1825 arg1Of retention,of
R1561 T1826 T1825 arg2Of GR,of
R1562 T1828 T1827 arg2Of mediated,is
R1563 T1828 T1829 arg1Of mediated,through
R1564 T1828 T1840 arg1Of mediated,","
R1565 T1828 T1841 arg1Of mediated,by
R1566 T1828 T1850 arg1Of mediated,by
R1567 T1828 T1855 arg1Of mediated,via
R1568 T1828 T1866 arg1Of mediated,[
R1569 T1834 T1830 arg1Of NL1,the
R1570 T1834 T1831 arg1Of NL1,nuclear
R1571 T1834 T1832 arg1Of NL1,localisation
R1572 T1834 T1833 arg1Of NL1,sequences
R1573 T1834 T1835 arg1Of NL1,and
R1574 T1835 T1829 arg2Of and,through
R1575 T1836 T1835 arg2Of NL2,and
R1576 T1836 T1837 arg1Of NL2,[
R1577 T1838 T1837 arg2Of 19,[
R1578 T1839 T1837 arg3Of ],[
R1579 T1841 T1849 arg1Of by,and
R1580 T1844 T1841 arg2Of signals,by
R1581 T1844 T1842 arg1Of signals,nuclear
R1582 T1844 T1843 arg1Of signals,retention
R1583 T1844 T1845 arg1Of signals,[
R1584 T1846 T1845 arg2Of 20,[
R1585 T1847 T1845 arg3Of ],[
R1586 T1849 T1848 arg1Of and,","
R1587 T1850 T1849 arg2Of by,and
R1588 T1851 T1850 arg2Of control,by
R1589 T1851 T1852 arg1Of control,of
R1590 T1854 T1852 arg2Of export,of
R1591 T1854 T1853 arg1Of export,nuclear
R1592 T1862 T1861 arg2Of CRM-1,(
R1593 T1863 T1861 arg3Of ),(
R1594 T1865 T1855 arg2Of pathway,via
R1595 T1865 T1856 arg1Of pathway,a
R1596 T1865 T1857 arg1Of pathway,chromosomal
R1597 T1865 T1858 arg1Of pathway,region
R1598 T1865 T1859 arg1Of pathway,maintenance
R1599 T1865 T1860 arg1Of pathway,1
R1600 T1865 T1861 arg1Of pathway,(
R1601 T1865 T1864 arg1Of pathway,dependent
R1602 T1867 T1866 arg2Of 21,[
R1603 T1868 T1866 arg3Of ],[
R1604 T1869 T1870 arg1Of NL1,","
R1605 T1869 T1871 arg1Of NL1,which
R1606 T1869 T1872 arg1Of NL1,is
R1607 T1869 T1873 arg1Of NL1,similar
R1608 T1869 T1879 arg1Of NL1,binds
R1609 T1873 T1872 arg2Of similar,is
R1610 T1873 T1874 arg1Of similar,to
R1611 T1877 T1874 arg2Of NLS,to
R1612 T1877 T1875 arg1Of NLS,the
R1613 T1877 T1876 arg1Of NLS,SV40
R1614 T1879 T1878 arg1Of binds,","
R1615 T1879 T1880 arg1Of binds,to
R1616 T1881 T1880 arg2Of importin-α,to
R1617 T1881 T1882 arg1Of importin-α,[
R1618 T1883 T1882 arg2Of 22,[
R1619 T1884 T1882 arg3Of ],[
R1620 T1885 T1886 arg1Of NL1,is
R1621 T1885 T1887 arg2Of NL1,activated
R1622 T1887 T1886 arg2Of activated,is
R1623 T1887 T1889 arg1Of activated,by
R1624 T1887 T1902 arg1Of activated,by
R1625 T1889 T1888 arg1Of by,both
R1626 T1889 T1901 arg1Of by,and
R1627 T1891 T1889 arg2Of agonists,by
R1628 T1891 T1890 arg1Of agonists,glucocorticoid
R1629 T1891 T1893 arg1Of agonists,as
R1630 T1893 T1892 arg1Of as,such
R1631 T1894 T1895 arg1Of dexamethasone,and
R1632 T1895 T1893 arg2Of and,as
R1633 T1897 T1895 arg2Of propionate,and
R1634 T1897 T1896 arg1Of propionate,fluticasone
R1635 T1897 T1898 arg1Of propionate,(
R1636 T1899 T1898 arg2Of FP,(
R1637 T1900 T1898 arg3Of ),(
R1638 T1902 T1901 arg2Of by,and
R1639 T1904 T1902 arg2Of antagonists,by
R1640 T1904 T1903 arg1Of antagonists,glucocorticoid
R1641 T1904 T1906 arg1Of antagonists,as
R1642 T1906 T1905 arg1Of as,such
R1643 T1907 T1906 arg2Of mifepristone,as
R1644 T1907 T1908 arg1Of mifepristone,(
R1645 T1907 T1911 arg1Of mifepristone,[
R1646 T1909 T1908 arg2Of RU486,(
R1647 T1910 T1908 arg3Of ),(
R1648 T1912 T1911 arg2Of 23,[
R1649 T1913 T1911 arg3Of ],[
R1650 T1914 T1915 arg1Of NL1,can
R1651 T1914 T1916 arg1Of NL1,be
R1652 T1914 T1917 arg2Of NL1,mutated
R1653 T1917 T1915 arg2Of mutated,can
R1654 T1917 T1916 arg2Of mutated,be
R1655 T1917 T1919 arg1Of mutated,and
R1656 T1919 T1918 arg1Of and,","
R1657 T1922 T1920 arg1Of GR,the
R1658 T1922 T1921 arg1Of GR,resulting
R1659 T1922 T1924 arg1Of GR,translocates
R1660 T1924 T1919 arg2Of translocates,and
R1661 T1924 T1923 arg1Of translocates,still
R1662 T1924 T1925 arg1Of translocates,to
R1663 T1924 T1928 arg1Of translocates,in
R1664 T1924 T1934 arg1Of translocates,via
R1665 T1927 T1925 arg2Of nucleus,to
R1666 T1927 T1926 arg1Of nucleus,the
R1667 T1928 T1933 arg1Of in,but
R1668 T1929 T1928 arg2Of response,in
R1669 T1929 T1930 arg1Of response,to
R1670 T1931 T1930 arg2Of ligands,to
R1671 T1933 T1932 arg1Of but,","
R1672 T1934 T1933 arg2Of via,but
R1673 T1935 T1934 arg2Of interaction,via
R1674 T1935 T1936 arg1Of interaction,with
R1675 T1937 T1936 arg2Of importin,with
R1676 T1937 T1938 arg1Of importin,7
R1677 T1937 T1939 arg1Of importin,","
R1678 T1941 T1939 arg2Of event,","
R1679 T1941 T1940 arg1Of event,an
R1680 T1941 T1942 arg1Of event,that
R1681 T1941 T1943 arg1Of event,requires
R1682 T1943 T1948 arg1Of requires,[
R1683 T1990 T1987 arg2Of and,of
R1684 T1947 T1943 arg2Of component,requires
R1685 T1992 T1993 arg1Of import,including
R1686 T1994 T1993 arg2Of chaperones,including
R1687 T1994 T1996 arg1Of chaperones,as
R1688 T1947 T1944 arg1Of component,an
R1689 T1996 T1995 arg1Of as,such
R1690 T1997 T1998 arg1Of Hsp90,and
R1691 T1947 T1945 arg1Of component,as-yet
R1692 T1998 T1996 arg2Of and,as
R1693 T1998 T2001 arg1Of and,[
R1694 T1947 T1946 arg1Of component,unknown
R1695 T2000 T1998 arg2Of immunophilins,and
R1696 T2000 T1999 arg1Of immunophilins,other
R1697 T1949 T1948 arg2Of 23,[
R1698 T2002 T2001 arg2Of 24,[
R1699 T2003 T2001 arg3Of ],[
R1700 T2004 T2005 arg1Of –,[
R1701 T2004 T2008 arg1Of –,and
R1702 T1950 T1948 arg3Of ],[
R1703 T2006 T2005 arg2Of 26,[
R1704 T2007 T2005 arg3Of ],[
R1705 T2008 T1990 arg2Of and,and
R1706 T2008 T1991 arg1Of and,nuclear
R1707 T2008 T1992 arg1Of and,import
R1708 T1951 T1952 arg1Of NL2,is
R1709 T2010 T2008 arg2Of proteins,and
R1710 T2010 T2009 arg1Of proteins,FK506-binding
R1711 T2010 T2011 arg1Of proteins,that
R1712 T2010 T2012 arg1Of proteins,may
R1713 T2010 T2013 arg1Of proteins,be
R1714 T2010 T2014 arg2Of proteins,linked
R1715 T1951 T1954 arg2Of NL2,defined
R1716 T2014 T2012 arg2Of linked,may
R1717 T2014 T2013 arg2Of linked,be
R1718 T2014 T2015 arg1Of linked,to
R1719 T1954 T1952 arg2Of defined,is
R1720 T2016 T2017 arg1Of dynein,and/or
R1721 T2017 T2015 arg2Of and/or,to
R1722 T2017 T2020 arg1Of and/or,[
R1723 T2019 T2017 arg2Of isomerase,and/or
R1724 T2019 T2018 arg1Of isomerase,peptidylprolyl
R1725 T2021 T2020 arg2Of 27,[
R1726 T2022 T2020 arg3Of ],[
R1727 T1954 T1953 arg1Of defined,poorly
R1728 T1954 T1955 arg1Of defined,","
R1729 T2025 T2024 arg2Of 28,[
R1730 T1954 T1956 modOf defined,residing
R1731 T2026 T2024 arg3Of ],[
R1732 T1954 T1962 arg1Of defined,and
R1733 T1956 T1957 arg1Of residing,in
R1734 T2031 T2029 arg1Of basis,the
R1735 T2031 T2030 arg1Of basis,molecular
R1736 T2031 T2032 arg1Of basis,for
R1737 T2031 T2040 arg1Of basis,is
R1738 T2031 T2043 arg2Of basis,understood
R1739 T1960 T1957 arg2Of domain,in
R1740 T2034 T2032 arg2Of inhibition,for
R1741 T2034 T2033 arg1Of inhibition,the
R1742 T2034 T2035 arg1Of inhibition,of
R1743 T2034 T2038 arg1Of inhibition,by
R1744 T2037 T2035 arg2Of cytokines,of
R1745 T2037 T2036 arg1Of cytokines,Th2
R1746 T2039 T2038 arg2Of corticosteroids,by
R1747 T1960 T1958 arg1Of domain,the
R1748 T1960 T1959 arg1Of domain,ligand-binding
R1749 T2043 T2027 arg1Of understood,However
R1750 T2043 T2028 arg1Of understood,","
R1751 T2043 T2040 arg2Of understood,is
R1752 T2043 T2041 arg1Of understood,not
R1753 T2043 T2042 arg1Of understood,well
R1754 T2043 T2044 arg1Of understood,","
R1755 T2043 T2045 arg1Of understood,because
R1756 T1962 T1961 arg1Of and,","
R1757 T2047 T2046 arg1Of genes,the
R1758 T2047 T2048 arg1Of genes,encoding
R1759 T2047 T2055 arg1Of genes,do
R1760 T2047 T2057 arg1Of genes,have
R1761 T1964 T1963 arg1Of less,much
R1762 T2047 T2066 arg1Of genes,are
R1763 T2047 T2069 arg2Of genes,regulated
R1764 T2049 T2050 arg1Of IL-4,","
R1765 T2050 T2053 arg1Of ",",and
R1766 T1964 T1965 arg1Of less,is
R1767 T1964 T1966 arg2Of less,known
R1768 T1966 T1962 arg2Of known,and
R1769 T2051 T2050 arg2Of IL-5,","
R1770 T2053 T2048 arg2Of and,encoding
R1771 T2053 T2052 arg1Of and,","
R1772 T2054 T2053 arg2Of IL-13,and
R1773 T2057 T2055 arg2Of have,do
R1774 T2057 T2056 arg1Of have,not
R1775 T2057 T2065 arg1Of have,and
R1776 T1966 T1965 arg2Of known,is
R1777 T1966 T1967 arg1Of known,about
R1778 T2061 T2057 arg2Of sequence,have
R1779 T2061 T2058 arg1Of sequence,any
R1780 T2061 T2059 arg1Of sequence,recognisable
R1781 T2061 T2060 arg1Of sequence,GRE
R1782 T2061 T2062 arg1Of sequence,[
R1783 T2063 T2062 arg2Of 29,[
R1784 T1969 T1967 arg2Of mechanism,about
R1785 T2064 T2062 arg3Of ],[
R1786 T2065 T2045 arg2Of and,because
R1787 T2065 T2079 arg1Of and,[
R1788 T2068 T2067 arg1Of partly,only
R1789 T1969 T1968 arg1Of mechanism,its
R1790 T2069 T2065 arg2Of regulated,and
R1791 T2069 T2066 arg2Of regulated,are
R1792 T2069 T2068 arg1Of regulated,partly
R1793 T2069 T2072 arg1Of regulated,in
R1794 T2069 T2075 arg1Of regulated,[
R1795 T2069 T2078 arg1Of regulated,–
R1796 T2071 T2069 arg1Of NF-κB,regulated
R1797 T2071 T2070 arg2Of NF-κB,by
R1798 T1969 T1970 arg1Of mechanism,of
R1799 T1972 T1970 arg2Of import,of
R1800 T2074 T2072 arg2Of cells,in
R1801 T2074 T2073 arg1Of cells,human
R1802 T2076 T2075 arg2Of 30,[
R1803 T2077 T2075 arg3Of ],[
R1804 T1972 T1971 arg1Of import,GR
R1805 T1972 T1973 arg1Of import,[
R1806 T2080 T2079 arg2Of 32,[
R1807 T1974 T1973 arg2Of 24,[
R1808 T2081 T2079 arg3Of ],[
R1809 T2083 T2084 arg1Of overexpression,and
R1810 T1975 T1973 arg3Of ],[
R1811 T2085 T2084 arg2Of CAT-reporter,and
R1812 T2086 T2082 arg2Of genes,Using
R1813 T2086 T2083 arg1Of genes,overexpression
R1814 T2086 T2085 arg1Of genes,CAT-reporter
R1815 T1977 T1976 arg1Of variety,A
R1816 T1977 T1978 arg1Of variety,of
R1817 T1977 T1981 arg1Of variety,are
R1818 T1977 T1983 arg1Of variety,important
R1819 T1980 T1978 arg2Of factors,of
R1820 T2088 T2089 arg1Of Lavender,and
R1821 T2089 T2082 arg1Of and,Using
R1822 T2089 T2094 arg1Of and,have
R1823 T2089 T2095 arg1Of and,shown
R1824 T2090 T2089 arg2Of colleagues,and
R1825 T2090 T2091 arg1Of colleagues,[
R1826 T2092 T2091 arg2Of 33,[
R1827 T2093 T2091 arg3Of ],[
R1828 T1980 T1979 arg1Of factors,other
R1829 T2095 T2082 modOf shown,Using
R1830 T1981 T1982 arg1Of are,also
R1831 T1981 T2023 arg1Of are,","
R1832 T1981 T2024 arg1Of are,[
R1833 T2095 T2087 arg1Of shown,","
R1834 T2095 T2094 arg2Of shown,have
R1835 T1983 T1981 arg2Of important,are
R1836 T2097 T2098 arg1Of GR,reduced
R1837 T2098 T2095 arg2Of reduced,shown
R1838 T2098 T2096 arg1Of reduced,that
R1839 T1983 T1984 arg1Of important,for
R1840 T2100 T2101 arg1Of IL-5,and
R1841 T1986 T1984 arg2Of regulation,for
R1842 T2102 T2101 arg2Of -13,and
R1843 T2104 T2098 arg2Of activity,reduced
R1844 T2104 T2099 arg1Of activity,GATA-3-mediated
R1845 T2104 T2100 arg1Of activity,IL-5
R1846 T2104 T2102 arg1Of activity,-13
R1847 T2104 T2103 arg1Of activity,promoter
R1848 T2104 T2105 arg1Of activity,in
R1849 T1986 T1985 arg1Of regulation,the
R1850 T1986 T1987 arg1Of regulation,of
R1851 T2109 T2105 arg2Of cells,in
R1852 T2109 T2106 arg1Of cells,human
R1853 T2109 T2107 arg1Of cells,CD4+
R1854 T2109 T2108 arg1Of cells,T
R1855 T1989 T1988 arg1Of activation,GR
R1856 T2111 T2110 arg1Of authors,The
R1857 T2111 T2112 arg1Of authors,postulated
R1858 T2115 T2114 arg1Of recruitment,local
R1859 T2115 T2116 arg1Of recruitment,of
R1860 T2115 T2118 arg1Of recruitment,may
R1861 T2115 T2119 arg1Of recruitment,alter
R1862 T1989 T1990 arg1Of activation,and
R1863 T2117 T2116 arg2Of GR,of
R1864 T2184 T2183 arg2Of anti-CD28,and
R1865 T2119 T2112 arg2Of alter,postulated
R1866 T2119 T2113 arg1Of alter,that
R1867 T2119 T2118 arg2Of alter,may
R1868 T2121 T2119 arg2Of ability,alter
R1869 T2121 T2120 arg1Of ability,the
R1870 T2185 T2180 arg1Of antibodies,activated
R1871 T2121 T2122 arg1Of ability,of
R1872 T2123 T2122 arg2Of GATA-3,of
R1873 T2123 T2125 modOf GATA-3,to
R1874 T2126 T2124 arg1Of bind,either
R1875 T2126 T2125 arg1Of bind,to
R1876 T2126 T2127 arg1Of bind,to
R1877 T2185 T2181 arg2Of antibodies,by
R1878 T2185 T2182 arg1Of antibodies,anti-CD3
R1879 T2130 T2127 arg2Of site,to
R1880 T2185 T2184 arg1Of antibodies,anti-CD28
R1881 T2130 T2128 arg1Of site,its
R1882 T2130 T2129 arg1Of site,target
R1883 T2130 T2131 arg1Of site,","
R1884 T2187 T2186 arg1Of vitro,in
R1885 T2133 T2132 arg1Of cause,to
R1886 T2133 T2137 arg1Of cause,or
R1887 T2135 T2133 arg2Of up-regulation,cause
R1888 T2135 T2134 arg1Of up-regulation,transcriptional
R1889 T2188 T2190 arg1Of We,studied
R1890 T2137 T2131 arg2Of or,","
R1891 T2137 T2136 arg1Of or,","
R1892 T2139 T2137 arg2Of maintain,or
R1893 T2139 T2138 arg1Of maintain,to
R1894 T2190 T2189 arg1Of studied,also
R1895 T2141 T2139 arg2Of environment,maintain
R1896 T2141 T2140 arg1Of environment,an
R1897 T2141 T2142 arg1Of environment,that
R1898 T2141 T2143 arg1Of environment,is
R1899 T2141 T2144 arg1Of environment,permissive
R1900 T2144 T2143 arg2Of permissive,is
R1901 T2144 T2145 arg1Of permissive,for
R1902 T2192 T2190 arg2Of effects,studied
R1903 T2146 T2145 arg2Of transcription,for
R1904 T2147 T2149 arg1Of We,investigated
R1905 T2192 T2191 arg1Of effects,the
R1906 T2149 T2148 arg1Of investigated,therefore
R1907 T2149 T2158 arg1Of investigated,","
R1908 T2149 T2159 arg1Of investigated,on
R1909 T2192 T2193 arg1Of effects,of
R1910 T2151 T2149 arg2Of effects,investigated
R1911 T2151 T2150 arg1Of effects,the
R1912 T2151 T2152 arg1Of effects,of
R1913 T2192 T2197 arg1Of effects,on
R1914 T2155 T2152 arg2Of corticosteroid,of
R1915 T2155 T2153 arg1Of corticosteroid,a
R1916 T2155 T2154 arg1Of corticosteroid,synthetic
R1917 T2155 T2156 arg1Of corticosteroid,","
R1918 T2157 T2156 arg2Of FP,","
R1919 T2196 T2193 arg2Of therapy,of
R1920 T2161 T2160 arg1Of phosphorylation,GATA-3
R1921 T2161 T2162 arg1Of phosphorylation,and
R1922 T2162 T2159 arg2Of and,on
R1923 T2162 T2165 arg1Of and,in
R1924 T2162 T2175 arg1Of and,in
R1925 T2164 T2162 arg2Of translocation,and
R1926 T2164 T2163 arg1Of translocation,nuclear
R1927 T2165 T2174 arg1Of in,and
R1928 T2196 T2194 arg2Of therapy,inhaled
R1929 T2196 T2195 arg1Of therapy,fluticasone
R1930 T2170 T2165 arg2Of line,in
R1931 T2170 T2166 arg1Of line,a
R1932 T2170 T2167 arg1Of line,T
R1933 T2170 T2168 arg1Of line,lymphocyte
R1934 T2170 T2169 arg1Of line,cell
R1935 T2170 T2171 arg1Of line,(
R1936 T2172 T2171 arg2Of HuT-78,(
R1937 T2200 T2197 arg2Of localization,on
R1938 T2173 T2171 arg3Of ),(
R1939 T2175 T2174 arg2Of in,and
R1940 T2200 T2198 arg1Of localization,GATA-3
R1941 T2179 T2175 arg2Of cells,in
R1942 T2179 T2176 arg1Of cells,peripheral
R1943 T2179 T2177 arg1Of cells,blood
R1944 T2179 T2178 arg1Of cells,mononuclear
R1945 T2179 T2180 arg2Of cells,activated
R1946 T2180 T2187 arg1Of activated,vitro
R1947 T2200 T2199 arg1Of localization,subcellular
R1948 T2182 T2183 arg1Of anti-CD3,and
R1949 T2200 T2201 arg1Of localization,in
R1950 T2205 T2201 arg2Of cells,in
R1951 T2205 T2202 arg1Of cells,peripheral
R1952 T2205 T2203 arg1Of cells,blood
R1953 T2205 T2204 arg1Of cells,mononuclear
R1954 T2205 T2206 arg1Of cells,(
R1955 T2205 T2209 arg1Of cells,from
R1956 T2207 T2206 arg2Of PBMCs,(
R1957 T2208 T2206 arg3Of ),(
R1959 T2210 T2209 arg2Of patients,from
R1962 T2210 T2211 arg1Of patients,with
R1964 T2212 T2211 arg2Of asthma,with

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T2213 410-415 Anaphor denotes which
T2214 402-408 Antecedent denotes GATA-3
T2215 1266-1268 Anaphor denotes it
T2216 1230-1236 Antecedent denotes GATA-3
T2217 1332-1335 Anaphor denotes its
T2218 2113-2116 Anaphor denotes its
T2219 2095-2101 Antecedent denotes GATA-3
T2220 2462-2467 Anaphor denotes which
T2221 2430-2454 Antecedent denotes glucocorticoid receptors
T2222 2506-2510 Anaphor denotes they
T2223 2462-2467 Antecedent denotes which
R1958 T2213 T2214 boundBy which,GATA-3
R1960 T2215 T2216 boundBy it,GATA-3
R1961 T2217 T2216 boundBy its,GATA-3
R1963 T2218 T2219 boundBy its,GATA-3
R1965 T2220 T2221 boundBy which,glucocorticoid receptors
R1966 T2222 T2220 boundBy they,which

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T2279 13-25 NNP denotes Inflammation
T2280 26-28 IN denotes in
T2281 29-37 JJ denotes allergic
T2282 38-46 NNS denotes diseases
T2283 47-51 JJ denotes such
T2284 52-54 IN denotes as
T2285 55-61 NN denotes asthma
T2286 61-62 , denotes ,
T2287 63-71 NN denotes rhinitis
T2288 71-72 , denotes ,
T2289 73-76 CC denotes and
T2290 77-83 JJ denotes atopic
T2291 84-94 NN denotes dermatitis
T2292 95-97 VBZ denotes is
T2293 98-106 VBN denotes mediated
T2294 107-110 IN denotes via
T2295 111-121 NN denotes expression
T2296 122-124 IN denotes of
T2297 125-128 DT denotes the
T2298 129-138 NNS denotes cytokines
T2299 139-150 VBP denotes interleukin
T2300 151-152 -LRB- denotes (
T2301 152-154 NNP denotes IL
T2302 154-155 -RRB- denotes )
T2303 155-157 CD denotes -4
T2304 157-158 , denotes ,
T2305 159-163 NN denotes IL-5
T2306 163-164 , denotes ,
T2307 165-168 CC denotes and
T2308 169-174 NN denotes IL-13
T2309 175-179 IN denotes from
T2310 180-181 NNP denotes T
T2311 182-190 JJ denotes helper-2
T2312 191-192 -LRB- denotes (
T2313 192-195 JJ denotes Th2
T2314 195-196 -RRB- denotes )
T2315 197-202 NNS denotes cells
T2316 202-203 . denotes .
T2317 204-208 NN denotes IL-4
T2318 209-212 CC denotes and
T2319 213-218 JJ denotes IL-13
T2320 219-227 VB denotes regulate
T2321 228-231 DT denotes the
T2322 232-242 NN denotes expression
T2323 243-245 IN denotes of
T2324 246-249 NNP denotes IgE
T2325 250-254 IN denotes from
T2326 255-256 NNP denotes B
T2327 257-268 NNS denotes lymphocytes
T2328 268-269 , denotes ,
T2329 270-277 IN denotes whereas
T2330 278-282 NNP denotes IL-5
T2331 283-288 VBZ denotes plays
T2332 289-290 DT denotes a
T2333 291-294 JJ denotes key
T2334 295-299 NN denotes role
T2335 300-302 IN denotes in
T2336 303-315 JJ denotes eosinophilic
T2337 316-328 NN denotes inflammation
T2338 329-330 NNP denotes [
T2339 330-331 CD denotes 1
T2340 331-332 NNP denotes ]
T2341 332-333 . denotes .
T2342 334-337 CD denotes Th2
T2343 338-347 NNS denotes cytokines
T2344 348-351 VBP denotes are
T2345 352-361 VBN denotes regulated
T2346 362-364 IN denotes by
T2347 365-368 DT denotes the
T2348 369-373 NN denotes zinc
T2349 374-380 NN denotes finger
T2350 381-394 NN denotes transcription
T2351 395-401 NN denotes factor
T2352 402-408 NNP denotes GATA-3
T2353 408-409 , denotes ,
T2354 410-415 WDT denotes which
T2355 416-418 VBZ denotes is
T2356 419-432 RB denotes predominantly
T2357 433-442 VBN denotes expressed
T2358 443-445 IN denotes in
T2359 446-449 JJ denotes Th2
T2360 450-455 NNS denotes cells
T2361 456-457 VBP denotes [
T2362 457-458 CD denotes 2
T2363 458-459 NNP denotes ]
T2364 459-460 , denotes ,
T2365 460-461 NNP denotes [
T2366 461-462 CD denotes 3
T2367 462-463 NNP denotes ]
T2368 463-464 . denotes .
T2369 465-471 JJ denotes GATA-3
T2370 472-482 VBZ denotes determines
T2371 483-486 NNP denotes Th2
T2372 487-491 NN denotes cell
T2373 492-507 NN denotes differentiation
T2374 508-511 CC denotes and
T2375 512-523 RB denotes selectively
T2376 524-533 VBZ denotes activates
T2377 534-537 DT denotes the
T2378 538-547 NNS denotes promoters
T2379 548-550 IN denotes of
T2380 551-555 NN denotes IL-4
T2381 555-556 , denotes ,
T2382 557-561 NN denotes IL-5
T2383 561-562 , denotes ,
T2384 563-566 CC denotes and
T2385 567-572 NN denotes IL-13
T2386 573-580 IN denotes through
T2387 581-590 NN denotes chromatin
T2388 591-602 VBG denotes remodelling
T2389 603-604 NNP denotes [
T2390 604-605 CD denotes 4
T2391 605-606 NNP denotes ]
T2392 607-608 NN denotes [
T2393 608-609 CD denotes 7
T2394 609-610 NNP denotes ]
T2395 610-611 . denotes .
T2396 612-615 DT denotes The
T2397 616-619 JJ denotes key
T2398 620-624 NN denotes role
T2399 625-627 IN denotes of
T2400 628-634 NN denotes GATA-3
T2401 635-637 IN denotes in
T2402 638-646 JJ denotes allergic
T2403 647-653 NN denotes airway
T2404 654-666 NN denotes inflammation
T2405 667-670 VBZ denotes has
T2406 671-675 VBN denotes been
T2407 676-688 VBN denotes demonstrated
T2408 689-691 IN denotes in
T2409 692-696 NNS denotes mice
T2410 697-699 IN denotes by
T2411 700-703 DT denotes the
T2412 704-711 VBN denotes reduced
T2413 712-719 NN denotes release
T2414 720-722 IN denotes of
T2415 723-726 JJ denotes Th2
T2416 727-736 NNS denotes cytokines
T2417 737-739 IN denotes in
T2418 740-747 NNS denotes animals
T2419 748-755 VBN denotes treated
T2420 756-760 IN denotes with
T2421 761-778 JJ denotes dominant-negative
T2422 779-786 NNS denotes mutants
T2423 787-789 IN denotes of
T2424 790-796 NN denotes GATA-3
T2425 797-800 CC denotes and
T2426 801-803 IN denotes by
T2427 804-809 JJ denotes local
T2428 810-821 NN denotes application
T2429 822-824 IN denotes of
T2430 825-834 JJ denotes antisense
T2431 835-851 NNS denotes oligonucleotides
T2432 852-854 TO denotes to
T2433 855-861 NNP denotes GATA-3
T2434 862-863 NNP denotes [
T2435 863-864 CD denotes 8
T2436 864-865 NNP denotes ]
T2437 865-866 , denotes ,
T2438 866-867 NNP denotes [
T2439 867-868 CD denotes 9
T2440 868-869 NNP denotes ]
T2441 869-870 . denotes .
T2442 871-882 RB denotes Furthermore
T2443 882-883 , denotes ,
T2444 884-895 JJ denotes conditional
T2445 896-905 NN denotes knock-out
T2446 906-908 IN denotes of
T2447 909-912 DT denotes the
T2448 913-918 NNP denotes Gata3
T2449 919-923 NN denotes gene
T2450 924-926 IN denotes in
T2451 927-931 NNS denotes mice
T2452 932-939 VBZ denotes reduces
T2453 940-950 NN denotes expression
T2454 951-953 IN denotes of
T2455 954-957 JJ denotes Th2
T2456 958-967 NNS denotes cytokines
T2457 968-970 IN denotes in
T2458 971-976 NN denotes vitro
T2459 977-980 CC denotes and
T2460 981-983 IN denotes in
T2461 984-988 NN denotes vivo
T2462 989-990 NNP denotes [
T2463 990-992 CD denotes 10
T2464 992-993 NNP denotes ]
T2465 993-994 , denotes ,
T2466 995-998 CC denotes and
T2467 999-1006 JJ denotes similar
T2468 1007-1014 NNS denotes results
T2469 1015-1019 VBP denotes have
T2470 1020-1024 VBN denotes been
T2471 1025-1033 VBN denotes reported
T2472 1034-1036 IN denotes in
T2473 1037-1045 JJ denotes isolated
T2474 1046-1052 NN denotes murine
T2475 1053-1056 NNP denotes CD4
T2476 1056-1057 NNP denotes +
T2477 1058-1069 VBZ denotes lymphocytes
T2478 1070-1071 NNP denotes [
T2479 1071-1073 CD denotes 11
T2480 1073-1074 NNP denotes ]
T2481 1074-1075 . denotes .
T2482 1076-1083 RB denotes Finally
T2483 1083-1084 , denotes ,
T2484 1085-1094 NN denotes knockdown
T2485 1095-1097 IN denotes of
T2486 1098-1104 JJ denotes GATA-3
T2487 1105-1115 NN denotes expression
T2488 1116-1121 VBG denotes using
T2489 1122-1127 NNP denotes siRNA
T2490 1128-1130 IN denotes in
T2491 1131-1136 JJ denotes human
T2492 1137-1138 NNP denotes T
T2493 1139-1144 NNS denotes cells
T2494 1145-1152 NNS denotes results
T2495 1153-1155 IN denotes in
T2496 1156-1160 NN denotes loss
T2497 1161-1163 IN denotes of
T2498 1164-1172 JJ denotes anti-CD3
T2499 1172-1173 NN denotes /
T2500 1173-1186 JJ denotes CD28-mediated
T2501 1187-1190 JJ denotes Th2
T2502 1191-1199 NN denotes cytokine
T2503 1200-1210 NN denotes expression
T2504 1211-1212 NNP denotes [
T2505 1212-1214 CD denotes 12
T2506 1214-1215 NNP denotes ]
T2507 1215-1216 . denotes .
T2508 1217-1219 IN denotes In
T2509 1220-1225 NN denotes order
T2510 1226-1229 IN denotes for
T2511 1230-1236 NN denotes GATA-3
T2512 1237-1239 TO denotes to
T2513 1240-1248 VB denotes regulate
T2514 1249-1253 NN denotes gene
T2515 1254-1264 NN denotes expression
T2516 1264-1265 , denotes ,
T2517 1266-1268 PRP denotes it
T2518 1269-1273 MD denotes must
T2519 1274-1285 VB denotes translocate
T2520 1286-1290 IN denotes from
T2521 1291-1294 DT denotes the
T2522 1295-1304 NN denotes cytoplasm
T2523 1305-1309 IN denotes into
T2524 1310-1313 DT denotes the
T2525 1314-1321 NN denotes nucleus
T2526 1322-1324 TO denotes to
T2527 1325-1331 VB denotes access
T2528 1332-1335 PRP$ denotes its
T2529 1336-1342 NN denotes target
T2530 1343-1348 NNS denotes genes
T2531 1348-1349 . denotes .
T2532 1350-1358 JJ denotes Enhanced
T2533 1359-1366 JJ denotes nuclear
T2534 1367-1377 NN denotes expression
T2535 1378-1380 IN denotes of
T2536 1381-1387 NN denotes GATA-3
T2537 1388-1397 VBG denotes following
T2538 1398-1399 NNP denotes T
T2539 1400-1404 NN denotes cell
T2540 1405-1413 NN denotes receptor
T2541 1414-1424 NN denotes activation
T2542 1425-1428 VBD denotes was
T2543 1429-1434 JJ denotes first
T2544 1435-1447 VBN denotes demonstrated
T2545 1448-1450 IN denotes in
T2546 1451-1457 NN denotes murine
T2547 1458-1459 NNP denotes T
T2548 1460-1465 NNS denotes cells
T2549 1466-1467 NNP denotes [
T2550 1467-1469 CD denotes 13
T2551 1469-1470 NNP denotes ]
T2552 1471-1474 CC denotes and
T2553 1475-1478 VBD denotes was
T2554 1479-1487 RB denotes recently
T2555 1488-1497 VBN denotes confirmed
T2556 1498-1500 IN denotes in
T2557 1501-1506 JJ denotes human
T2558 1507-1508 NNP denotes T
T2559 1509-1514 NNS denotes cells
T2560 1515-1524 VBG denotes following
T2561 1525-1526 NNP denotes T
T2562 1527-1531 NN denotes cell
T2563 1532-1540 NN denotes receptor
T2564 1541-1544 CC denotes and
T2565 1545-1556 NN denotes co-receptor
T2566 1557-1568 NN denotes stimulation
T2567 1569-1570 NNP denotes [
T2568 1570-1572 CD denotes 12
T2569 1572-1573 NNP denotes ]
T2570 1573-1574 . denotes .
T2571 1575-1581 JJ denotes GATA-3
T2572 1582-1590 VBZ denotes contains
T2573 1591-1592 DT denotes a
T2574 1593-1602 JJ denotes classical
T2575 1603-1610 JJ denotes nuclear
T2576 1611-1617 NN denotes import
T2577 1618-1624 NN denotes signal
T2578 1625-1626 NNP denotes [
T2579 1626-1628 CD denotes 14
T2580 1628-1629 NNP denotes ]
T2581 1630-1633 CC denotes and
T2582 1634-1636 VBZ denotes is
T2583 1637-1648 VBN denotes transported
T2584 1649-1653 IN denotes into
T2585 1654-1657 DT denotes the
T2586 1658-1665 NN denotes nucleus
T2587 1666-1668 IN denotes by
T2588 1669-1672 DT denotes the
T2589 1673-1680 JJ denotes nuclear
T2590 1681-1687 NN denotes import
T2591 1688-1695 NN denotes protein
T2592 1696-1706 NN denotes importin-α
T2593 1707-1708 -LRB- denotes (
T2594 1708-1712 RB denotes also
T2595 1713-1718 VBN denotes known
T2596 1719-1721 IN denotes as
T2597 1722-1735 NN denotes karyopherin-α
T2598 1735-1736 -RRB- denotes )
T2599 1737-1738 NNP denotes [
T2600 1738-1740 CD denotes 12
T2601 1740-1741 NNP denotes ]
T2602 1741-1742 . denotes .
T2603 1743-1751 NN denotes Deletion
T2604 1752-1754 IN denotes of
T2605 1755-1756 DT denotes a
T2606 1757-1763 NN denotes region
T2607 1764-1776 VBG denotes encompassing
T2608 1777-1780 DT denotes the
T2609 1781-1787 JJ denotes GATA-3
T2610 1788-1795 JJ denotes nuclear
T2611 1796-1808 NN denotes localisation
T2612 1809-1817 NN denotes sequence
T2613 1818-1819 -LRB- denotes (
T2614 1819-1822 NNP denotes NLS
T2615 1822-1823 -RRB- denotes )
T2616 1824-1830 NN denotes region
T2617 1831-1833 IN denotes in
T2618 1834-1840 NN denotes murine
T2619 1841-1844 CC denotes and
T2620 1845-1850 JJ denotes human
T2621 1851-1856 NNS denotes cells
T2622 1857-1865 VBZ denotes prevents
T2623 1866-1869 PRP$ denotes its
T2624 1870-1877 JJ denotes nuclear
T2625 1878-1890 NN denotes localisation
T2626 1891-1892 NNP denotes [
T2627 1892-1894 CD denotes 12
T2628 1894-1895 NNP denotes ]
T2629 1895-1896 , denotes ,
T2630 1896-1897 NNP denotes [
T2631 1897-1899 CD denotes 14
T2632 1899-1900 NNP denotes ]
T2633 1900-1901 . denotes .
T2634 1902-1905 DT denotes The
T2635 1906-1914 NN denotes affinity
T2636 1915-1917 IN denotes of
T2637 1918-1921 DT denotes the
T2638 1922-1932 JJ denotes importin-α
T2639 1933-1936 NNP denotes NLS
T2640 1937-1948 NN denotes interaction
T2641 1949-1951 VBZ denotes is
T2642 1952-1961 VBN denotes regulated
T2643 1962-1964 IN denotes by
T2644 1965-1980 NN denotes phosphorylation
T2645 1981-1982 NNP denotes [
T2646 1982-1984 CD denotes 15
T2647 1984-1985 NNP denotes ]
T2648 1985-1986 , denotes ,
T2649 1987-1990 CC denotes and
T2650 1991-1993 PRP denotes we
T2651 1994-1998 VBP denotes have
T2652 1999-2004 VBN denotes shown
T2653 2005-2009 IN denotes that
T2654 2010-2013 CD denotes p38
T2655 2014-2031 JJ denotes mitogen-activated
T2656 2032-2039 NN denotes protein
T2657 2040-2046 NN denotes kinase
T2658 2047-2048 -LRB- denotes (
T2659 2048-2052 NNP denotes MAPK
T2660 2052-2053 -RRB- denotes )
T2661 2054-2059 VBZ denotes plays
T2662 2060-2061 DT denotes a
T2663 2062-2070 JJ denotes critical
T2664 2071-2075 NN denotes role
T2665 2076-2078 IN denotes in
T2666 2079-2094 VBG denotes phosphorylating
T2667 2095-2101 NN denotes GATA-3
T2668 2102-2104 TO denotes to
T2669 2105-2112 VB denotes enhance
T2670 2113-2116 PRP$ denotes its
T2671 2117-2128 NN denotes interaction
T2672 2129-2133 IN denotes with
T2673 2134-2144 JJ denotes importin-α
T2674 2145-2148 CC denotes and
T2675 2149-2159 JJ denotes subsequent
T2676 2160-2169 NN denotes transport
T2677 2170-2174 IN denotes into
T2678 2175-2178 DT denotes the
T2679 2179-2186 NN denotes nucleus
T2680 2187-2188 NNP denotes [
T2681 2188-2190 CD denotes 12
T2682 2190-2191 NNP denotes ]
T2683 2191-2192 . denotes .
T2684 2193-2208 NNS denotes Corticosteroids
T2685 2209-2212 VBP denotes are
T2686 2213-2219 RB denotes highly
T2687 2220-2229 JJ denotes effective
T2688 2230-2232 IN denotes in
T2689 2233-2236 DT denotes the
T2690 2237-2246 NN denotes treatment
T2691 2247-2249 IN denotes of
T2692 2250-2258 JJ denotes allergic
T2693 2259-2271 NN denotes inflammation
T2694 2271-2272 , denotes ,
T2695 2273-2277 IN denotes with
T2696 2278-2284 JJ denotes marked
T2697 2285-2296 NN denotes suppression
T2698 2297-2299 IN denotes of
T2699 2300-2303 JJ denotes Th2
T2700 2304-2313 NNS denotes cytokines
T2701 2314-2316 IN denotes in
T2702 2317-2324 NNS denotes airways
T2703 2325-2327 IN denotes of
T2704 2328-2336 NNS denotes patients
T2705 2337-2341 IN denotes with
T2706 2342-2348 NN denotes asthma
T2707 2349-2350 NNP denotes [
T2708 2350-2352 CD denotes 16
T2709 2352-2353 NNP denotes ]
T2710 2353-2354 . denotes .
T2711 2355-2370 NNS denotes Corticosteroids
T2712 2371-2378 VBP denotes mediate
T2713 2379-2384 PRP$ denotes their
T2714 2385-2402 JJ denotes anti-inflammatory
T2715 2403-2410 NNS denotes effects
T2716 2411-2418 IN denotes through
T2717 2419-2426 JJ denotes binding
T2718 2427-2429 TO denotes to
T2719 2430-2444 JJ denotes glucocorticoid
T2720 2445-2454 NNS denotes receptors
T2721 2455-2456 -LRB- denotes (
T2722 2456-2459 NNS denotes GRs
T2723 2459-2460 -RRB- denotes )
T2724 2460-2461 , denotes ,
T2725 2462-2467 WDT denotes which
T2726 2468-2472 RB denotes then
T2727 2473-2484 VBP denotes translocate
T2728 2485-2487 TO denotes to
T2729 2488-2491 DT denotes the
T2730 2492-2499 NN denotes nucleus
T2731 2500-2505 WRB denotes where
T2732 2506-2510 PRP denotes they
T2733 2511-2519 VBP denotes interact
T2734 2520-2524 IN denotes with
T2735 2525-2539 JJ denotes glucocorticoid
T2736 2540-2548 NN denotes response
T2737 2549-2557 NNS denotes elements
T2738 2558-2559 -LRB- denotes (
T2739 2559-2563 NNS denotes GREs
T2740 2563-2564 -RRB- denotes )
T2741 2565-2567 IN denotes in
T2742 2568-2571 DT denotes the
T2743 2572-2580 NN denotes promoter
T2744 2581-2588 NNS denotes regions
T2745 2589-2591 IN denotes of
T2746 2592-2609 JJ denotes steroid-sensitive
T2747 2610-2615 NNS denotes genes
T2748 2615-2616 . denotes .
T2749 2617-2630 RB denotes Alternatively
T2750 2630-2631 , denotes ,
T2751 2632-2641 VBN denotes activated
T2752 2642-2644 NNP denotes GR
T2753 2645-2654 NNS denotes interacts
T2754 2655-2659 IN denotes with
T2755 2660-2671 NN denotes coactivator
T2756 2672-2681 NNS denotes molecules
T2757 2682-2684 TO denotes to
T2758 2685-2693 VB denotes suppress
T2759 2694-2697 DT denotes the
T2760 2698-2708 NN denotes expression
T2761 2709-2711 IN denotes of
T2762 2712-2724 JJ denotes inflammatory
T2763 2725-2730 NNS denotes genes
T2764 2731-2733 IN denotes by
T2765 2734-2744 VBG denotes inhibiting
T2766 2745-2748 DT denotes the
T2767 2749-2755 NN denotes action
T2768 2756-2758 IN denotes of
T2769 2759-2774 JJ denotes proinflammatory
T2770 2775-2788 NN denotes transcription
T2771 2789-2796 NNS denotes factors
T2772 2797-2801 JJ denotes such
T2773 2802-2804 IN denotes as
T2774 2805-2812 JJ denotes nuclear
T2775 2813-2822 NNP denotes factor-κB
T2776 2823-2824 -LRB- denotes (
T2777 2824-2829 NNP denotes NF-κB
T2778 2829-2830 -RRB- denotes )
T2779 2831-2838 IN denotes through
T2780 2839-2842 DT denotes the
T2781 2843-2854 NN denotes recruitment
T2782 2855-2857 IN denotes of
T2783 2858-2870 NN denotes co-repressor
T2784 2871-2880 NNS denotes molecules
T2785 2881-2885 JJ denotes such
T2786 2886-2888 IN denotes as
T2787 2889-2896 NN denotes histone
T2788 2897-2910 JJ denotes deacetylase-2
T2789 2911-2912 NNP denotes [
T2790 2912-2914 CD denotes 17
T2791 2914-2915 NNP denotes ]
T2792 2915-2916 , denotes ,
T2793 2916-2917 NNP denotes [
T2794 2917-2919 CD denotes 18
T2795 2919-2920 NNP denotes ]
T2796 2920-2921 . denotes .
T2797 2922-2929 NNP denotes Nuclear
T2798 2930-2942 NN denotes localisation
T2799 2943-2946 CC denotes and
T2800 2947-2956 NN denotes retention
T2801 2957-2959 IN denotes of
T2802 2960-2962 NNP denotes GR
T2803 2963-2965 VBZ denotes is
T2804 2966-2974 VBN denotes mediated
T2805 2975-2982 IN denotes through
T2806 2983-2986 DT denotes the
T2807 2987-2994 JJ denotes nuclear
T2808 2995-3007 NN denotes localisation
T2809 3008-3017 NNS denotes sequences
T2810 3018-3021 NNP denotes NL1
T2811 3022-3025 CC denotes and
T2812 3026-3029 NNP denotes NL2
T2813 3030-3031 NNP denotes [
T2814 3031-3033 CD denotes 19
T2815 3033-3034 NNP denotes ]
T2816 3034-3035 , denotes ,
T2817 3036-3038 IN denotes by
T2818 3039-3046 JJ denotes nuclear
T2819 3047-3056 NN denotes retention
T2820 3057-3064 VBZ denotes signals
T2821 3065-3066 NNP denotes [
T2822 3066-3068 CD denotes 20
T2823 3068-3069 NNP denotes ]
T2824 3069-3070 , denotes ,
T2825 3071-3074 CC denotes and
T2826 3075-3077 IN denotes by
T2827 3078-3085 NN denotes control
T2828 3086-3088 IN denotes of
T2829 3089-3096 JJ denotes nuclear
T2830 3097-3103 NN denotes export
T2831 3104-3107 IN denotes via
T2832 3108-3109 DT denotes a
T2833 3110-3121 JJ denotes chromosomal
T2834 3122-3128 NN denotes region
T2835 3129-3140 NN denotes maintenance
T2836 3141-3142 CD denotes 1
T2837 3143-3144 -LRB- denotes (
T2838 3144-3149 NN denotes CRM-1
T2839 3149-3150 -RRB- denotes )
T2840 3151-3160 JJ denotes dependent
T2841 3161-3168 NN denotes pathway
T2842 3169-3170 NNP denotes [
T2843 3170-3172 CD denotes 21
T2844 3172-3173 NNP denotes ]
T2845 3173-3174 . denotes .
T2846 3175-3178 CD denotes NL1
T2847 3178-3179 , denotes ,
T2848 3180-3185 WDT denotes which
T2849 3186-3188 VBZ denotes is
T2850 3189-3196 JJ denotes similar
T2851 3197-3199 TO denotes to
T2852 3200-3203 DT denotes the
T2853 3204-3208 NNP denotes SV40
T2854 3209-3212 NNP denotes NLS
T2855 3212-3213 , denotes ,
T2856 3214-3219 VBZ denotes binds
T2857 3220-3222 TO denotes to
T2858 3223-3233 VB denotes importin-α
T2859 3234-3235 NNP denotes [
T2860 3235-3237 CD denotes 22
T2861 3237-3238 NNP denotes ]
T2862 3238-3239 . denotes .
T2863 3240-3243 CD denotes NL1
T2864 3244-3246 VBZ denotes is
T2865 3247-3256 VBN denotes activated
T2866 3257-3261 DT denotes both
T2867 3262-3264 IN denotes by
T2868 3265-3279 JJ denotes glucocorticoid
T2869 3280-3288 NNS denotes agonists
T2870 3289-3293 JJ denotes such
T2871 3294-3296 IN denotes as
T2872 3297-3310 NN denotes dexamethasone
T2873 3311-3314 CC denotes and
T2874 3315-3326 NN denotes fluticasone
T2875 3327-3337 NN denotes propionate
T2876 3338-3339 -LRB- denotes (
T2877 3339-3341 NNP denotes FP
T2878 3341-3342 -RRB- denotes )
T2879 3343-3346 CC denotes and
T2880 3347-3349 IN denotes by
T2881 3350-3364 JJ denotes glucocorticoid
T2882 3365-3376 NNS denotes antagonists
T2883 3377-3381 JJ denotes such
T2884 3382-3384 IN denotes as
T2885 3385-3397 NN denotes mifepristone
T2886 3398-3399 -LRB- denotes (
T2887 3399-3404 NNP denotes RU486
T2888 3404-3405 -RRB- denotes )
T2889 3406-3407 NNP denotes [
T2890 3407-3409 CD denotes 23
T2891 3409-3410 NNP denotes ]
T2892 3410-3411 . denotes .
T2893 3412-3415 CD denotes NL1
T2894 3416-3419 MD denotes can
T2895 3420-3422 VB denotes be
T2896 3423-3430 VBN denotes mutated
T2897 3430-3431 , denotes ,
T2898 3432-3435 CC denotes and
T2899 3436-3439 DT denotes the
T2900 3440-3449 VBG denotes resulting
T2901 3450-3452 NNP denotes GR
T2902 3453-3458 RB denotes still
T2903 3459-3471 VBZ denotes translocates
T2904 3472-3474 TO denotes to
T2905 3475-3478 DT denotes the
T2906 3479-3486 NN denotes nucleus
T2907 3487-3489 IN denotes in
T2908 3490-3498 NN denotes response
T2909 3499-3501 TO denotes to
T2910 3502-3509 NNS denotes ligands
T2911 3509-3510 , denotes ,
T2912 3511-3514 CC denotes but
T2913 3515-3518 IN denotes via
T2914 3519-3530 NN denotes interaction
T2915 3531-3535 IN denotes with
T2916 3536-3544 NN denotes importin
T2917 3545-3546 CD denotes 7
T2918 3546-3547 , denotes ,
T2919 3548-3550 DT denotes an
T2920 3551-3556 NN denotes event
T2921 3557-3561 WDT denotes that
T2922 3562-3570 VBZ denotes requires
T2923 3571-3573 DT denotes an
T2924 3574-3580 RB denotes as-yet
T2925 3581-3588 JJ denotes unknown
T2926 3589-3598 NN denotes component
T2927 3599-3600 NNP denotes [
T2928 3600-3602 CD denotes 23
T2929 3602-3603 NNP denotes ]
T2930 3603-3604 . denotes .
T2931 3605-3608 CD denotes NL2
T2932 3609-3611 VBZ denotes is
T2933 3612-3618 RB denotes poorly
T2934 3619-3626 VBN denotes defined
T2935 3626-3627 , denotes ,
T2936 3628-3636 VBG denotes residing
T2937 3637-3639 IN denotes in
T2938 3640-3643 DT denotes the
T2939 3644-3658 JJ denotes ligand-binding
T2940 3659-3665 NN denotes domain
T2941 3665-3666 , denotes ,
T2942 3667-3670 CC denotes and
T2943 3671-3675 RB denotes much
T2944 3676-3680 JJR denotes less
T2945 3681-3683 VBZ denotes is
T2946 3684-3689 VBN denotes known
T2947 3690-3695 IN denotes about
T2948 3696-3699 PRP$ denotes its
T2949 3700-3709 NN denotes mechanism
T2950 3710-3712 IN denotes of
T2951 3713-3715 NNP denotes GR
T2952 3716-3722 NN denotes import
T2953 3723-3724 NNP denotes [
T2954 3724-3726 CD denotes 24
T2955 3726-3727 NNP denotes ]
T2956 3727-3728 . denotes .
T2957 3729-3730 DT denotes A
T2958 3731-3738 NN denotes variety
T2959 3739-3741 IN denotes of
T2960 3742-3747 JJ denotes other
T2961 3748-3755 NNS denotes factors
T2962 3756-3759 VBP denotes are
T2963 3760-3764 RB denotes also
T2964 3765-3774 JJ denotes important
T2965 3775-3778 IN denotes for
T2966 3779-3782 DT denotes the
T2967 3783-3793 NN denotes regulation
T2968 3794-3796 IN denotes of
T2969 3797-3799 NNP denotes GR
T2970 3800-3810 NN denotes activation
T2971 3811-3814 CC denotes and
T2972 3815-3822 JJ denotes nuclear
T2973 3823-3829 NN denotes import
T2974 3830-3839 VBG denotes including
T2975 3840-3850 NNS denotes chaperones
T2976 3851-3855 JJ denotes such
T2977 3856-3858 IN denotes as
T2978 3859-3864 NNP denotes Hsp90
T2979 3865-3868 CC denotes and
T2980 3869-3874 JJ denotes other
T2981 3875-3888 NNS denotes immunophilins
T2982 3889-3890 NNP denotes [
T2983 3890-3892 CD denotes 24
T2984 3892-3893 NNP denotes ]
T2985 3894-3895 NNP denotes [
T2986 3895-3897 CD denotes 26
T2987 3897-3898 NNP denotes ]
T2988 3899-3902 CC denotes and
T2989 3903-3916 JJ denotes FK506-binding
T2990 3917-3925 NNS denotes proteins
T2991 3926-3930 WDT denotes that
T2992 3931-3934 MD denotes may
T2993 3935-3937 VB denotes be
T2994 3938-3944 VBN denotes linked
T2995 3945-3947 TO denotes to
T2996 3948-3954 VB denotes dynein
T2997 3955-3961 CC denotes and/or
T2998 3962-3976 VB denotes peptidylprolyl
T2999 3977-3986 JJ denotes isomerase
T3000 3987-3988 NNP denotes [
T3001 3988-3990 CD denotes 27
T3002 3990-3991 NNP denotes ]
T3003 3991-3992 , denotes ,
T3004 3992-3993 NNP denotes [
T3005 3993-3995 CD denotes 28
T3006 3995-3996 NNP denotes ]
T3007 3996-3997 . denotes .
T3008 3998-4005 RB denotes However
T3009 4005-4006 , denotes ,
T3010 4007-4010 DT denotes the
T3011 4011-4020 JJ denotes molecular
T3012 4021-4026 NN denotes basis
T3013 4027-4030 IN denotes for
T3014 4031-4034 DT denotes the
T3015 4035-4045 NN denotes inhibition
T3016 4046-4048 IN denotes of
T3017 4049-4052 JJ denotes Th2
T3018 4053-4062 NNS denotes cytokines
T3019 4063-4065 IN denotes by
T3020 4066-4081 NNS denotes corticosteroids
T3021 4082-4084 VBZ denotes is
T3022 4085-4088 RB denotes not
T3023 4089-4093 RB denotes well
T3024 4094-4104 VBN denotes understood
T3025 4104-4105 , denotes ,
T3026 4106-4113 IN denotes because
T3027 4114-4117 DT denotes the
T3028 4118-4123 NNS denotes genes
T3029 4124-4132 VBG denotes encoding
T3030 4133-4137 NN denotes IL-4
T3031 4137-4138 , denotes ,
T3032 4139-4143 NN denotes IL-5
T3033 4143-4144 , denotes ,
T3034 4145-4148 CC denotes and
T3035 4149-4154 NNP denotes IL-13
T3036 4155-4157 VBP denotes do
T3037 4158-4161 RB denotes not
T3038 4162-4166 VB denotes have
T3039 4167-4170 DT denotes any
T3040 4171-4183 JJ denotes recognisable
T3041 4184-4187 NNP denotes GRE
T3042 4188-4196 NN denotes sequence
T3043 4197-4198 NNP denotes [
T3044 4198-4200 CD denotes 29
T3045 4200-4201 NNP denotes ]
T3046 4202-4205 CC denotes and
T3047 4206-4209 VBP denotes are
T3048 4210-4214 RB denotes only
T3049 4215-4221 RB denotes partly
T3050 4222-4231 VBN denotes regulated
T3051 4232-4234 IN denotes by
T3052 4235-4240 NNP denotes NF-κB
T3053 4241-4243 IN denotes in
T3054 4244-4249 JJ denotes human
T3055 4250-4255 NNS denotes cells
T3056 4256-4257 NNP denotes [
T3057 4257-4259 CD denotes 30
T3058 4259-4260 NNP denotes ]
T3059 4261-4262 NNP denotes [
T3060 4262-4264 CD denotes 32
T3061 4264-4265 NNP denotes ]
T3062 4265-4266 . denotes .
T3063 4267-4272 VBG denotes Using
T3064 4273-4287 NN denotes overexpression
T3065 4288-4291 CC denotes and
T3066 4292-4304 JJ denotes CAT-reporter
T3067 4305-4310 NNS denotes genes
T3068 4310-4311 , denotes ,
T3069 4312-4320 NNP denotes Lavender
T3070 4321-4324 CC denotes and
T3071 4325-4335 NNS denotes colleagues
T3072 4336-4337 NNP denotes [
T3073 4337-4339 CD denotes 33
T3074 4339-4340 NNP denotes ]
T3075 4341-4345 VBP denotes have
T3076 4346-4351 VBN denotes shown
T3077 4352-4356 IN denotes that
T3078 4357-4359 NNP denotes GR
T3079 4360-4367 VBD denotes reduced
T3080 4368-4383 JJ denotes GATA-3-mediated
T3081 4384-4388 NN denotes IL-5
T3082 4389-4392 CC denotes and
T3083 4393-4396 CD denotes -13
T3084 4397-4405 NN denotes promoter
T3085 4406-4414 NN denotes activity
T3086 4415-4417 IN denotes in
T3087 4418-4423 JJ denotes human
T3088 4424-4427 NNP denotes CD4
T3089 4427-4428 CD denotes +
T3090 4429-4430 NNP denotes T
T3091 4431-4436 NNS denotes cells
T3092 4436-4437 . denotes .
T3093 4438-4441 DT denotes The
T3094 4442-4449 NNS denotes authors
T3095 4450-4460 VBD denotes postulated
T3096 4461-4465 IN denotes that
T3097 4466-4471 JJ denotes local
T3098 4472-4483 NN denotes recruitment
T3099 4484-4486 IN denotes of
T3100 4487-4489 NNP denotes GR
T3101 4490-4493 MD denotes may
T3102 4494-4499 VB denotes alter
T3103 4500-4503 DT denotes the
T3104 4504-4511 NN denotes ability
T3105 4512-4514 IN denotes of
T3106 4515-4521 JJ denotes GATA-3
T3107 4522-4528 CC denotes either
T3108 4529-4531 TO denotes to
T3109 4532-4536 NN denotes bind
T3110 4537-4539 TO denotes to
T3111 4540-4543 PRP$ denotes its
T3112 4544-4550 NN denotes target
T3113 4551-4555 NN denotes site
T3114 4555-4556 , denotes ,
T3115 4557-4559 TO denotes to
T3116 4560-4565 VB denotes cause
T3117 4566-4581 JJ denotes transcriptional
T3118 4582-4595 NN denotes up-regulation
T3119 4595-4596 , denotes ,
T3120 4597-4599 CC denotes or
T3121 4600-4602 TO denotes to
T3122 4603-4611 VB denotes maintain
T3123 4612-4614 DT denotes an
T3124 4615-4626 NN denotes environment
T3125 4627-4631 WDT denotes that
T3126 4632-4634 VBZ denotes is
T3127 4635-4645 JJ denotes permissive
T3128 4646-4649 IN denotes for
T3129 4650-4663 NN denotes transcription
T3130 4663-4664 . denotes .
T3131 4665-4667 PRP denotes We
T3132 4668-4677 RB denotes therefore
T3133 4678-4690 VBD denotes investigated
T3134 4691-4694 DT denotes the
T3135 4695-4702 NNS denotes effects
T3136 4703-4705 IN denotes of
T3137 4706-4707 DT denotes a
T3138 4708-4717 JJ denotes synthetic
T3139 4718-4732 NN denotes corticosteroid
T3140 4732-4733 , denotes ,
T3141 4734-4736 NNP denotes FP
T3142 4736-4737 , denotes ,
T3143 4738-4740 IN denotes on
T3144 4741-4747 JJ denotes GATA-3
T3145 4748-4763 NN denotes phosphorylation
T3146 4764-4767 CC denotes and
T3147 4768-4775 JJ denotes nuclear
T3148 4776-4789 NN denotes translocation
T3149 4790-4792 IN denotes in
T3150 4793-4794 DT denotes a
T3151 4795-4796 NNP denotes T
T3152 4797-4807 NN denotes lymphocyte
T3153 4808-4812 NN denotes cell
T3154 4813-4817 NN denotes line
T3155 4818-4819 -LRB- denotes (
T3156 4819-4825 JJ denotes HuT-78
T3157 4825-4826 -RRB- denotes )
T3158 4827-4830 CC denotes and
T3159 4831-4833 IN denotes in
T3160 4834-4844 JJ denotes peripheral
T3161 4845-4850 NN denotes blood
T3162 4851-4862 NN denotes mononuclear
T3163 4863-4868 NNS denotes cells
T3164 4869-4878 VBN denotes activated
T3165 4879-4881 IN denotes by
T3166 4882-4890 JJ denotes anti-CD3
T3167 4891-4894 CC denotes and
T3168 4895-4904 JJ denotes anti-CD28
T3169 4905-4915 NNS denotes antibodies
T3170 4916-4918 IN denotes in
T3171 4919-4924 NN denotes vitro
T3172 4924-4925 . denotes .
T3173 4926-4928 PRP denotes We
T3174 4929-4933 RB denotes also
T3175 4934-4941 VBD denotes studied
T3176 4942-4945 DT denotes the
T3177 4946-4953 NNS denotes effects
T3178 4954-4956 IN denotes of
T3179 4957-4964 JJ denotes inhaled
T3180 4965-4976 NN denotes fluticasone
T3181 4977-4984 NN denotes therapy
T3182 4985-4987 IN denotes on
T3183 4988-4994 JJ denotes GATA-3
T3184 4995-5006 JJ denotes subcellular
T3185 5007-5019 NN denotes localization
T3186 5020-5022 IN denotes in
T3187 5023-5033 JJ denotes peripheral
T3188 5034-5039 NN denotes blood
T3189 5040-5051 NN denotes mononuclear
T3190 5052-5057 NNS denotes cells
T3191 5058-5059 -LRB- denotes (
T3192 5059-5064 NNS denotes PBMCs
T3193 5064-5065 -RRB- denotes )
T3194 5066-5070 IN denotes from
T3195 5071-5079 NNS denotes patients
T3196 5080-5084 IN denotes with
T3197 5085-5091 NN denotes asthma
T3198 5091-5092 . denotes .
R1977 T2289 T2287 cc and,rhinitis
R1978 T2290 T2291 amod atopic,dermatitis
R1979 T2291 T2287 conj dermatitis,rhinitis
R1980 T2292 T2293 auxpass is,mediated
R1981 T2293 T2293 ROOT mediated,mediated
R1982 T2294 T2293 prep via,mediated
R1983 T2295 T2294 pobj expression,via
R1984 T2296 T2295 prep of,expression
R1985 T2297 T2298 det the,cytokines
R1986 T2298 T2296 pobj cytokines,of
R1987 T2299 T2293 conj interleukin,mediated
R1988 T2300 T2301 punct (,IL
R1989 T2301 T2299 appos IL,interleukin
R1990 T2302 T2301 punct ),IL
R1991 T2303 T2301 nummod -4,IL
R1992 T2327 T2325 pobj lymphocytes,from
R1993 T2304 T2301 punct ",",IL
R1994 T2328 T2320 punct ",",regulate
R1995 T2305 T2301 appos IL-5,IL
R1996 T2306 T2305 punct ",",IL-5
R1997 T2329 T2331 mark whereas,plays
R1998 T2307 T2305 cc and,IL-5
R1999 T2330 T2331 nsubj IL-5,plays
R2000 T2331 T2320 advcl plays,regulate
R2001 T2308 T2305 conj IL-13,IL-5
R2002 T2332 T2334 det a,role
R2003 T2333 T2334 amod key,role
R2004 T2334 T2331 dobj role,plays
R2005 T2335 T2334 prep in,role
R2006 T2309 T2308 prep from,IL-13
R2007 T2336 T2337 amod eosinophilic,inflammation
R2008 T2337 T2335 pobj inflammation,in
R2009 T2310 T2311 compound T,helper-2
R2010 T2338 T2340 quantmod [,]
R2011 T2339 T2340 nummod 1,]
R2012 T2340 T2331 npadvmod ],plays
R2013 T2311 T2309 pobj helper-2,from
R2014 T2341 T2320 punct .,regulate
R2015 T2342 T2343 nummod Th2,cytokines
R2016 T2343 T2345 nsubjpass cytokines,regulated
R2017 T2312 T2311 punct (,helper-2
R2018 T2344 T2345 auxpass are,regulated
R2019 T2313 T2311 appos Th2,helper-2
R2020 T2314 T2311 punct ),helper-2
R2021 T2315 T2309 pobj cells,from
R2022 T2345 T2345 ROOT regulated,regulated
R2023 T2346 T2345 agent by,regulated
R2024 T2347 T2351 det the,factor
R2025 T2348 T2350 compound zinc,transcription
R2026 T2349 T2350 compound finger,transcription
R2027 T2316 T2293 punct .,mediated
R2028 T2350 T2351 compound transcription,factor
R2029 T2351 T2346 pobj factor,by
R2030 T2317 T2320 nsubj IL-4,regulate
R2031 T2352 T2351 appos GATA-3,factor
R2032 T2353 T2351 punct ",",factor
R2033 T2354 T2357 nsubjpass which,expressed
R2034 T2318 T2317 cc and,IL-4
R2035 T2355 T2357 auxpass is,expressed
R2036 T2356 T2357 advmod predominantly,expressed
R2037 T2357 T2351 relcl expressed,factor
R2038 T2319 T2317 conj IL-13,IL-4
R2039 T2358 T2357 prep in,expressed
R2040 T2320 T2320 ROOT regulate,regulate
R2041 T2321 T2322 det the,expression
R2042 T2359 T2360 amod Th2,cells
R2043 T2322 T2320 dobj expression,regulate
R2044 T2360 T2358 pobj cells,in
R2045 T2361 T2363 nmod [,]
R2046 T2362 T2363 nummod 2,]
R2047 T2363 T2367 nmod ],]
R2048 T2323 T2322 prep of,expression
R2049 T2364 T2363 punct ",",]
R2050 T2324 T2323 pobj IgE,of
R2051 T2325 T2320 prep from,regulate
R2052 T2365 T2363 conj [,]
R2053 T2326 T2327 compound B,lymphocytes
R2054 T2366 T2367 nummod 3,]
R2055 T2367 T2345 npadvmod ],regulated
R2056 T2368 T2345 punct .,regulated
R2057 T2456 T2454 pobj cytokines,of
R2058 T2369 T2370 nsubj GATA-3,determines
R2059 T2370 T2370 ROOT determines,determines
R2060 T2371 T2373 compound Th2,differentiation
R2061 T2372 T2373 compound cell,differentiation
R2062 T2457 T2452 prep in,reduces
R2063 T2373 T2370 dobj differentiation,determines
R2064 T2374 T2370 cc and,determines
R2065 T2375 T2376 advmod selectively,activates
R2066 T2458 T2457 pobj vitro,in
R2067 T2376 T2370 conj activates,determines
R2068 T2377 T2378 det the,promoters
R2069 T2378 T2376 dobj promoters,activates
R2070 T2459 T2457 cc and,in
R2071 T2379 T2378 prep of,promoters
R2072 T2380 T2379 pobj IL-4,of
R2073 T2381 T2380 punct ",",IL-4
R2074 T2382 T2380 conj IL-5,IL-4
R2075 T2383 T2382 punct ",",IL-5
R2076 T2384 T2382 cc and,IL-5
R2077 T2385 T2382 conj IL-13,IL-5
R2078 T2460 T2457 conj in,in
R2079 T2386 T2376 prep through,activates
R2080 T2387 T2388 compound chromatin,remodelling
R2081 T2388 T2389 compound remodelling,[
R2082 T2389 T2391 nmod [,]
R2083 T2461 T2460 pobj vivo,in
R2084 T2390 T2391 nummod 4,]
R2085 T2391 T2386 pobj ],through
R2086 T2392 T2394 nmod [,]
R2087 T2462 T2464 nmod [,]
R2088 T2393 T2392 nummod 7,[
R2089 T2394 T2391 appos ],]
R2090 T2463 T2464 nummod 10,]
R2091 T2395 T2370 punct .,determines
R2092 T2396 T2398 det The,role
R2093 T2397 T2398 amod key,role
R2094 T2464 T2452 dobj ],reduces
R2095 T2398 T2407 nsubjpass role,demonstrated
R2096 T2399 T2398 prep of,role
R2097 T2400 T2399 pobj GATA-3,of
R2098 T2465 T2464 punct ",",]
R2099 T2401 T2400 prep in,GATA-3
R2100 T2402 T2404 amod allergic,inflammation
R2101 T2403 T2404 compound airway,inflammation
R2102 T2466 T2464 cc and,]
R2103 T2404 T2401 pobj inflammation,in
R2104 T2405 T2407 aux has,demonstrated
R2105 T2406 T2407 auxpass been,demonstrated
R2106 T2407 T2407 ROOT demonstrated,demonstrated
R2107 T2467 T2468 amod similar,results
R2108 T2408 T2407 prep in,demonstrated
R2109 T2409 T2408 pobj mice,in
R2110 T2468 T2464 conj results,]
R2111 T2410 T2407 agent by,demonstrated
R2112 T2469 T2471 aux have,reported
R2113 T2411 T2413 det the,release
R2114 T2470 T2471 auxpass been,reported
R2115 T2412 T2413 amod reduced,release
R2116 T2471 T2452 conj reported,reduces
R2117 T2413 T2410 pobj release,by
R2118 T2414 T2413 prep of,release
R2119 T2415 T2416 amod Th2,cytokines
R2120 T2472 T2471 prep in,reported
R2121 T2416 T2414 pobj cytokines,of
R2122 T2417 T2416 prep in,cytokines
R2123 T2418 T2417 pobj animals,in
R2124 T2473 T2474 amod isolated,murine
R2125 T2419 T2418 acl treated,animals
R2126 T2420 T2419 prep with,treated
R2127 T2421 T2422 amod dominant-negative,mutants
R2128 T2474 T2472 pobj murine,in
R2129 T2422 T2420 pobj mutants,with
R2130 T2423 T2422 prep of,mutants
R2131 T2475 T2476 compound CD4,+
R2132 T2476 T2477 nsubj +,lymphocytes
R2133 T2424 T2423 pobj GATA-3,of
R2134 T2425 T2420 cc and,with
R2135 T2426 T2419 agent by,treated
R2136 T2477 T2471 parataxis lymphocytes,reported
R2137 T2427 T2428 amod local,application
R2138 T2428 T2426 pobj application,by
R2139 T2429 T2428 prep of,application
R2140 T2478 T2480 nmod [,]
R2141 T2430 T2431 amod antisense,oligonucleotides
R2142 T2431 T2429 pobj oligonucleotides,of
R2143 T2479 T2480 nummod 11,]
R2144 T2432 T2419 prep to,treated
R2145 T2433 T2436 nmod GATA-3,]
R2146 T2434 T2436 nmod [,]
R2147 T2480 T2477 dobj ],lymphocytes
R2148 T2435 T2436 nummod 8,]
R2149 T2436 T2432 pobj ],to
R2150 T2437 T2436 punct ",",]
R2151 T2438 T2440 nmod [,]
R2152 T2481 T2477 punct .,lymphocytes
R2153 T2439 T2440 nummod 9,]
R2154 T2440 T2436 appos ],]
R2155 T2482 T2488 advmod Finally,using
R2156 T2441 T2407 punct .,demonstrated
R2157 T2442 T2452 advmod Furthermore,reduces
R2158 T2443 T2445 punct ",",knock-out
R2159 T2483 T2488 punct ",",using
R2160 T2444 T2445 amod conditional,knock-out
R2161 T2445 T2452 nsubj knock-out,reduces
R2162 T2446 T2445 prep of,knock-out
R2163 T2484 T2488 nsubj knockdown,using
R2164 T2447 T2449 det the,gene
R2165 T2448 T2449 compound Gata3,gene
R2166 T2449 T2446 pobj gene,of
R2167 T2450 T2445 prep in,knock-out
R2168 T2485 T2484 prep of,knockdown
R2169 T2451 T2450 pobj mice,in
R2170 T2452 T2452 ROOT reduces,reduces
R2171 T2486 T2487 amod GATA-3,expression
R2172 T2453 T2452 dobj expression,reduces
R2173 T2454 T2453 prep of,expression
R2174 T2455 T2456 compound Th2,cytokines
R2175 T2487 T2485 pobj expression,of
R2176 T2488 T2488 ROOT using,using
R2177 T2489 T2488 dobj siRNA,using
R2178 T2490 T2488 prep in,using
R2179 T2491 T2493 amod human,cells
R2180 T2553 T2555 auxpass was,confirmed
R2181 T2554 T2555 advmod recently,confirmed
R2182 T2492 T2493 compound T,cells
R2183 T2555 T2544 conj confirmed,demonstrated
R2184 T2556 T2555 prep in,confirmed
R2185 T2557 T2559 amod human,cells
R2186 T2493 T2494 compound cells,results
R2187 T2558 T2559 compound T,cells
R2188 T2559 T2556 pobj cells,in
R2189 T2560 T2555 prep following,confirmed
R2190 T2494 T2490 pobj results,in
R2191 T2561 T2563 compound T,receptor
R2192 T2562 T2563 compound cell,receptor
R2193 T2563 T2560 pobj receptor,following
R2194 T2495 T2494 prep in,results
R2195 T2564 T2563 cc and,receptor
R2196 T2565 T2566 compound co-receptor,stimulation
R2197 T2496 T2495 pobj loss,in
R2198 T2566 T2563 conj stimulation,receptor
R2199 T2567 T2569 nmod [,]
R2200 T2568 T2569 nummod 12,]
R2201 T2497 T2496 prep of,loss
R2202 T2569 T2566 nmod ],stimulation
R2203 T2570 T2544 punct .,demonstrated
R2204 T2571 T2572 nsubj GATA-3,contains
R2205 T2498 T2503 amod anti-CD3,expression
R2206 T2499 T2503 nmod /,expression
R2207 T2572 T2572 ROOT contains,contains
R2208 T2500 T2503 nmod CD28-mediated,expression
R2209 T2573 T2577 det a,signal
R2210 T2574 T2577 amod classical,signal
R2211 T2501 T2503 amod Th2,expression
R2212 T2575 T2576 amod nuclear,import
R2213 T2576 T2577 compound import,signal
R2214 T2577 T2572 dobj signal,contains
R2215 T2502 T2503 compound cytokine,expression
R2216 T2578 T2580 nmod [,]
R2217 T2579 T2580 nummod 14,]
R2218 T2580 T2577 appos ],signal
R2219 T2503 T2497 pobj expression,of
R2220 T2581 T2572 cc and,contains
R2221 T2504 T2506 nmod [,]
R2222 T2582 T2583 auxpass is,transported
R2223 T2505 T2506 nummod 12,]
R2224 T2583 T2572 conj transported,contains
R2225 T2584 T2583 prep into,transported
R2226 T2585 T2586 det the,nucleus
R2227 T2586 T2584 pobj nucleus,into
R2228 T2587 T2583 agent by,transported
R2229 T2506 T2503 appos ],expression
R2230 T2588 T2591 det the,protein
R2231 T2589 T2591 amod nuclear,protein
R2232 T2590 T2591 compound import,protein
R2233 T2507 T2488 punct .,using
R2234 T2591 T2587 pobj protein,by
R2235 T2592 T2583 conj importin-α,transported
R2236 T2593 T2595 punct (,known
R2237 T2508 T2519 prep In,translocate
R2238 T2594 T2595 advmod also,known
R2239 T2595 T2592 acl known,importin-α
R2240 T2596 T2595 prep as,known
R2241 T2509 T2508 pobj order,In
R2242 T2597 T2596 pobj karyopherin-α,as
R2243 T2598 T2592 punct ),importin-α
R2244 T2599 T2601 nmod [,]
R2245 T2510 T2513 mark for,regulate
R2246 T2600 T2601 nummod 12,]
R2247 T2601 T2572 dep ],contains
R2248 T2602 T2572 punct .,contains
R2249 T2511 T2513 nsubj GATA-3,regulate
R2250 T2603 T2622 nsubj Deletion,prevents
R2251 T2604 T2603 prep of,Deletion
R2252 T2605 T2606 det a,region
R2253 T2512 T2513 aux to,regulate
R2254 T2606 T2604 pobj region,of
R2255 T2607 T2606 acl encompassing,region
R2256 T2608 T2612 det the,sequence
R2257 T2513 T2509 advcl regulate,order
R2258 T2609 T2612 amod GATA-3,sequence
R2259 T2610 T2611 amod nuclear,localisation
R2260 T2514 T2515 compound gene,expression
R2261 T2611 T2612 compound localisation,sequence
R2262 T2515 T2513 dobj expression,regulate
R2263 T2612 T2607 dobj sequence,encompassing
R2264 T2613 T2612 punct (,sequence
R2265 T2614 T2612 appos NLS,sequence
R2266 T2516 T2519 punct ",",translocate
R2267 T2615 T2612 punct ),sequence
R2268 T2616 T2606 conj region,region
R2269 T2617 T2603 prep in,Deletion
R2270 T2517 T2519 nsubj it,translocate
R2271 T2618 T2617 pobj murine,in
R2272 T2619 T2618 cc and,murine
R2273 T2620 T2621 amod human,cells
R2274 T2518 T2519 aux must,translocate
R2275 T2621 T2618 conj cells,murine
R2276 T2622 T2622 ROOT prevents,prevents
R2277 T2623 T2625 poss its,localisation
R2278 T2624 T2625 amod nuclear,localisation
R2279 T2625 T2622 dobj localisation,prevents
R2280 T2519 T2519 ROOT translocate,translocate
R2281 T2626 T2628 nmod [,]
R2282 T2520 T2519 prep from,translocate
R2283 T2627 T2628 nummod 12,]
R2284 T2628 T2622 dobj ],prevents
R2285 T2629 T2628 punct ",",]
R2286 T2521 T2522 det the,cytoplasm
R2287 T2630 T2628 conj [,]
R2288 T2631 T2632 nummod 14,]
R2289 T2632 T2628 conj ],]
R2290 T2522 T2520 pobj cytoplasm,from
R2291 T2633 T2622 punct .,prevents
R2292 T2634 T2635 det The,affinity
R2293 T2635 T2642 nsubjpass affinity,regulated
R2294 T2523 T2519 prep into,translocate
R2295 T2636 T2635 prep of,affinity
R2296 T2637 T2638 det the,importin-α
R2297 T2638 T2636 pobj importin-α,of
R2298 T2524 T2525 det the,nucleus
R2299 T2639 T2640 compound NLS,interaction
R2300 T2640 T2642 nsubjpass interaction,regulated
R2301 T2641 T2642 auxpass is,regulated
R2302 T2525 T2523 pobj nucleus,into
R2303 T2642 T2642 ROOT regulated,regulated
R2304 T2643 T2642 agent by,regulated
R2305 T2644 T2645 compound phosphorylation,[
R2306 T2526 T2527 aux to,access
R2307 T2645 T2647 nmod [,]
R2308 T2646 T2647 nummod 15,]
R2309 T2647 T2643 pobj ],by
R2310 T2527 T2519 advcl access,translocate
R2311 T2648 T2642 punct ",",regulated
R2312 T2649 T2642 cc and,regulated
R2313 T2528 T2530 poss its,genes
R2314 T2529 T2530 compound target,genes
R2315 T2650 T2652 nsubj we,shown
R2316 T2530 T2527 dobj genes,access
R2317 T2651 T2652 aux have,shown
R2318 T2652 T2642 conj shown,regulated
R2319 T2653 T2661 mark that,plays
R2320 T2531 T2519 punct .,translocate
R2321 T2654 T2657 nummod p38,kinase
R2322 T2655 T2657 amod mitogen-activated,kinase
R2323 T2656 T2657 compound protein,kinase
R2324 T2532 T2534 amod Enhanced,expression
R2325 T2657 T2661 nsubj kinase,plays
R2326 T2658 T2659 punct (,MAPK
R2327 T2533 T2534 amod nuclear,expression
R2328 T2659 T2657 appos MAPK,kinase
R2329 T2660 T2657 punct ),kinase
R2330 T2534 T2544 nsubjpass expression,demonstrated
R2331 T2661 T2652 ccomp plays,shown
R2332 T2662 T2664 det a,role
R2333 T2663 T2664 amod critical,role
R2334 T2535 T2534 prep of,expression
R2335 T2664 T2661 dobj role,plays
R2336 T2665 T2664 prep in,role
R2337 T2536 T2535 pobj GATA-3,of
R2338 T2537 T2534 acl following,expression
R2341 T2538 T2541 compound T,activation
R2345 T2539 T2540 compound cell,receptor
R2350 T2540 T2541 compound receptor,activation
R2353 T2541 T2537 pobj activation,following
R2357 T2542 T2544 auxpass was,demonstrated
R2358 T2680 T2682 nmod [,]
R2359 T2681 T2682 nummod 12,]
R2360 T2682 T2679 appos ],nucleus
R2361 T2543 T2544 advmod first,demonstrated
R2362 T2683 T2652 punct .,shown
R2363 T2684 T2685 nsubj Corticosteroids,are
R2364 T2685 T2685 ROOT are,are
R2365 T2686 T2687 advmod highly,effective
R2366 T2544 T2544 ROOT demonstrated,demonstrated
R2367 T2687 T2685 acomp effective,are
R2368 T2688 T2687 prep in,effective
R2369 T2689 T2690 det the,treatment
R2370 T2545 T2544 prep in,demonstrated
R2371 T2690 T2688 pobj treatment,in
R2372 T2691 T2690 prep of,treatment
R2373 T2546 T2547 compound murine,T
R2374 T2692 T2693 amod allergic,inflammation
R2375 T2693 T2691 pobj inflammation,of
R2376 T2694 T2685 punct ",",are
R2377 T2695 T2685 prep with,are
R2378 T2696 T2697 amod marked,suppression
R2379 T2697 T2695 pobj suppression,with
R2380 T2547 T2548 compound T,cells
R2381 T2698 T2697 prep of,suppression
R2382 T2699 T2700 amod Th2,cytokines
R2383 T2700 T2698 pobj cytokines,of
R2384 T2701 T2697 prep in,suppression
R2385 T2548 T2545 pobj cells,in
R2386 T2702 T2701 pobj airways,in
R2387 T2703 T2702 prep of,airways
R2388 T2704 T2703 pobj patients,of
R2389 T2549 T2551 nmod [,]
R2390 T2705 T2704 prep with,patients
R2391 T2706 T2705 pobj asthma,with
R2392 T2707 T2709 quantmod [,]
R2393 T2550 T2551 nummod 13,]
R2394 T2708 T2709 nummod 16,]
R2395 T2709 T2685 npadvmod ],are
R2396 T2710 T2685 punct .,are
R2397 T2711 T2712 nsubj Corticosteroids,mediate
R2398 T2551 T2548 appos ],cells
R2399 T2712 T2712 ROOT mediate,mediate
R2400 T2713 T2715 poss their,effects
R2401 T2552 T2544 cc and,demonstrated
R2402 T2714 T2715 amod anti-inflammatory,effects
R2403 T2747 T2745 pobj genes,of
R2404 T2715 T2712 dobj effects,mediate
R2405 T2716 T2712 prep through,mediate
R2406 T2748 T2712 punct .,mediate
R2407 T2717 T2716 amod binding,through
R2408 T2749 T2751 advmod Alternatively,activated
R2409 T2718 T2717 prep to,binding
R2410 T2750 T2751 punct ",",activated
R2411 T2719 T2720 amod glucocorticoid,receptors
R2412 T2751 T2751 ROOT activated,activated
R2413 T2752 T2753 compound GR,interacts
R2414 T2720 T2718 pobj receptors,to
R2415 T2721 T2720 punct (,receptors
R2416 T2722 T2720 appos GRs,receptors
R2417 T2753 T2751 dobj interacts,activated
R2418 T2723 T2720 punct ),receptors
R2419 T2724 T2720 punct ",",receptors
R2420 T2725 T2727 nsubj which,translocate
R2421 T2754 T2753 prep with,interacts
R2422 T2726 T2727 advmod then,translocate
R2423 T2727 T2720 relcl translocate,receptors
R2424 T2755 T2756 compound coactivator,molecules
R2425 T2728 T2727 prep to,translocate
R2426 T2729 T2730 det the,nucleus
R2427 T2730 T2728 pobj nucleus,to
R2428 T2756 T2754 pobj molecules,with
R2429 T2731 T2733 advmod where,interact
R2430 T2757 T2758 aux to,suppress
R2431 T2732 T2733 nsubj they,interact
R2432 T2733 T2730 relcl interact,nucleus
R2433 T2734 T2733 prep with,interact
R2434 T2758 T2751 advcl suppress,activated
R2435 T2735 T2737 amod glucocorticoid,elements
R2436 T2736 T2737 compound response,elements
R2437 T2737 T2734 pobj elements,with
R2438 T2759 T2760 det the,expression
R2439 T2738 T2739 punct (,GREs
R2440 T2760 T2758 dobj expression,suppress
R2441 T2739 T2737 appos GREs,elements
R2442 T2740 T2737 punct ),elements
R2443 T2761 T2760 prep of,expression
R2444 T2741 T2733 prep in,interact
R2445 T2742 T2744 det the,regions
R2446 T2743 T2744 compound promoter,regions
R2447 T2762 T2763 amod inflammatory,genes
R2448 T2744 T2741 pobj regions,in
R2449 T2745 T2744 prep of,regions
R2450 T2746 T2747 amod steroid-sensitive,genes
R2451 T2763 T2761 pobj genes,of
R2452 T2764 T2758 prep by,suppress
R2453 T2765 T2764 pcomp inhibiting,by
R2454 T2766 T2767 det the,action
R2455 T2844 T2841 appos ],pathway
R2456 T2767 T2765 dobj action,inhibiting
R2457 T2845 T2820 punct .,signals
R2458 T2846 T2856 nsubj NL1,binds
R2459 T2768 T2767 prep of,action
R2460 T2847 T2846 punct ",",NL1
R2461 T2848 T2849 nsubj which,is
R2462 T2849 T2846 relcl is,NL1
R2463 T2769 T2771 amod proinflammatory,factors
R2464 T2850 T2849 acomp similar,is
R2465 T2851 T2850 prep to,similar
R2466 T2852 T2854 det the,NLS
R2467 T2770 T2771 compound transcription,factors
R2468 T2853 T2854 compound SV40,NLS
R2469 T2854 T2851 pobj NLS,to
R2470 T2855 T2849 punct ",",is
R2471 T2771 T2768 pobj factors,of
R2472 T2856 T2856 ROOT binds,binds
R2473 T2857 T2858 aux to,importin-α
R2474 T2858 T2856 xcomp importin-α,binds
R2475 T2772 T2773 amod such,as
R2476 T2859 T2858 dobj [,importin-α
R2477 T2860 T2861 nummod 22,]
R2478 T2861 T2856 npadvmod ],binds
R2479 T2862 T2856 punct .,binds
R2480 T2863 T2865 nsubjpass NL1,activated
R2481 T2864 T2865 auxpass is,activated
R2482 T2773 T2771 prep as,factors
R2483 T2865 T2865 ROOT activated,activated
R2484 T2866 T2867 advmod both,by
R2485 T2867 T2865 agent by,activated
R2486 T2868 T2869 amod glucocorticoid,agonists
R2487 T2774 T2775 amod nuclear,factor-κB
R2488 T2869 T2867 pobj agonists,by
R2489 T2775 T2773 pobj factor-κB,as
R2490 T2870 T2871 amod such,as
R2491 T2871 T2869 prep as,agonists
R2492 T2872 T2871 pobj dexamethasone,as
R2493 T2873 T2872 cc and,dexamethasone
R2494 T2776 T2775 punct (,factor-κB
R2495 T2874 T2875 compound fluticasone,propionate
R2496 T2875 T2872 conj propionate,dexamethasone
R2497 T2876 T2877 punct (,FP
R2498 T2877 T2875 appos FP,propionate
R2499 T2777 T2775 appos NF-κB,factor-κB
R2500 T2878 T2877 punct ),FP
R2501 T2879 T2867 cc and,by
R2502 T2880 T2867 conj by,by
R2503 T2778 T2775 punct ),factor-κB
R2504 T2779 T2765 prep through,inhibiting
R2505 T2881 T2882 amod glucocorticoid,antagonists
R2506 T2780 T2781 det the,recruitment
R2507 T2781 T2779 pobj recruitment,through
R2508 T2882 T2880 pobj antagonists,by
R2509 T2782 T2781 prep of,recruitment
R2510 T2883 T2884 amod such,as
R2511 T2783 T2784 compound co-repressor,molecules
R2512 T2784 T2782 pobj molecules,of
R2513 T2884 T2882 prep as,antagonists
R2514 T2885 T2884 pobj mifepristone,as
R2515 T2785 T2786 amod such,as
R2516 T2886 T2885 punct (,mifepristone
R2517 T2887 T2889 nmod RU486,[
R2518 T2888 T2889 punct ),[
R2519 T2786 T2784 prep as,molecules
R2520 T2889 T2865 npadvmod [,activated
R2521 T2890 T2891 nummod 23,]
R2522 T2891 T2889 appos ],[
R2523 T2787 T2789 compound histone,[
R2524 T2892 T2865 punct .,activated
R2525 T2893 T2896 nsubjpass NL1,mutated
R2526 T2788 T2789 compound deacetylase-2,[
R2527 T2894 T2896 aux can,mutated
R2528 T2789 T2786 pobj [,as
R2529 T2895 T2896 auxpass be,mutated
R2530 T2896 T2896 ROOT mutated,mutated
R2531 T2790 T2791 nummod 17,]
R2532 T2897 T2896 punct ",",mutated
R2533 T2898 T2896 cc and,mutated
R2534 T2899 T2901 det the,GR
R2535 T2791 T2789 conj ],[
R2536 T2900 T2901 amod resulting,GR
R2537 T2901 T2903 nsubj GR,translocates
R2538 T2902 T2903 advmod still,translocates
R2539 T2792 T2791 punct ",",]
R2540 T2903 T2896 conj translocates,mutated
R2541 T2904 T2903 prep to,translocates
R2542 T2905 T2906 det the,nucleus
R2543 T2793 T2791 conj [,]
R2544 T2906 T2904 pobj nucleus,to
R2545 T2907 T2903 prep in,translocates
R2546 T2908 T2907 pobj response,in
R2547 T2794 T2795 nummod 18,]
R2548 T2909 T2908 prep to,response
R2549 T2910 T2909 pobj ligands,to
R2550 T2911 T2903 punct ",",translocates
R2551 T2795 T2791 conj ],]
R2552 T2912 T2903 cc but,translocates
R2553 T2913 T2903 conj via,translocates
R2554 T2914 T2913 pobj interaction,via
R2555 T2796 T2751 punct .,activated
R2556 T2915 T2914 prep with,interaction
R2557 T2916 T2915 pobj importin,with
R2558 T2917 T2916 nummod 7,importin
R2559 T2797 T2798 compound Nuclear,localisation
R2560 T2918 T2916 punct ",",importin
R2561 T2919 T2920 det an,event
R2562 T2920 T2916 appos event,importin
R2563 T2798 T2804 nsubjpass localisation,mediated
R2564 T2921 T2922 nsubj that,requires
R2565 T2922 T2920 relcl requires,event
R2566 T2923 T2926 det an,component
R2567 T2799 T2798 cc and,localisation
R2568 T2924 T2925 advmod as-yet,unknown
R2569 T2925 T2926 amod unknown,component
R2570 T2926 T2922 dobj component,requires
R2571 T2800 T2798 conj retention,localisation
R2572 T2927 T2926 appos [,component
R2573 T2801 T2800 prep of,retention
R2574 T2928 T2929 nummod 23,]
R2575 T2929 T2922 dobj ],requires
R2576 T2802 T2801 pobj GR,of
R2577 T2930 T2903 punct .,translocates
R2578 T2931 T2934 nsubjpass NL2,defined
R2579 T2932 T2934 auxpass is,defined
R2580 T2933 T2934 advmod poorly,defined
R2581 T2934 T2934 ROOT defined,defined
R2582 T2935 T2934 punct ",",defined
R2583 T2803 T2804 auxpass is,mediated
R2584 T2936 T2934 advcl residing,defined
R2585 T2937 T2936 prep in,residing
R2586 T2938 T2940 det the,domain
R2587 T2804 T2820 ccomp mediated,signals
R2588 T2939 T2940 amod ligand-binding,domain
R2589 T2940 T2937 pobj domain,in
R2590 T2805 T2804 prep through,mediated
R2591 T2806 T2809 det the,sequences
R2592 T2807 T2808 amod nuclear,localisation
R2593 T2941 T2934 punct ",",defined
R2594 T2808 T2809 compound localisation,sequences
R2595 T2942 T2934 cc and,defined
R2596 T2943 T2944 advmod much,less
R2597 T2944 T2946 advmod less,known
R2598 T2809 T2805 pobj sequences,through
R2599 T2945 T2946 auxpass is,known
R2600 T2946 T2934 conj known,defined
R2601 T2947 T2946 prep about,known
R2602 T2810 T2809 appos NL1,sequences
R2603 T2948 T2949 poss its,mechanism
R2604 T2949 T2947 pobj mechanism,about
R2605 T2950 T2949 prep of,mechanism
R2606 T2811 T2810 cc and,NL1
R2607 T2951 T2953 compound GR,[
R2608 T2952 T2953 compound import,[
R2609 T2953 T2950 pobj [,of
R2610 T2812 T2813 compound NL2,[
R2611 T2954 T2955 nummod 24,]
R2612 T2955 T2949 appos ],mechanism
R2613 T2956 T2934 punct .,defined
R2614 T2813 T2810 conj [,NL1
R2615 T2957 T2958 det A,variety
R2616 T2958 T2962 nsubj variety,are
R2617 T2959 T2958 prep of,variety
R2618 T2814 T2815 nummod 19,]
R2619 T2960 T2961 amod other,factors
R2620 T2961 T2959 pobj factors,of
R2621 T2962 T2962 ROOT are,are
R2622 T2815 T2810 conj ],NL1
R2623 T2963 T2962 advmod also,are
R2624 T2964 T2962 acomp important,are
R2625 T2965 T2964 prep for,important
R2626 T2816 T2804 punct ",",mediated
R2627 T2966 T2967 det the,regulation
R2628 T2967 T2965 pobj regulation,for
R2629 T2968 T2967 prep of,regulation
R2630 T2969 T2970 compound GR,activation
R2631 T2970 T2968 pobj activation,of
R2632 T2817 T2804 agent by,mediated
R2633 T2971 T2970 cc and,activation
R2634 T2818 T2819 amod nuclear,retention
R2635 T2972 T2973 amod nuclear,import
R2636 T2819 T2817 pobj retention,by
R2637 T2973 T2970 conj import,activation
R2638 T2974 T2967 prep including,regulation
R2639 T2975 T2974 pobj chaperones,including
R2640 T2820 T2820 ROOT signals,signals
R2641 T2976 T2977 amod such,as
R2642 T2821 T2823 nmod [,]
R2643 T2822 T2823 nummod 20,]
R2644 T2977 T2975 prep as,chaperones
R2645 T2823 T2820 dobj ],signals
R2646 T2824 T2820 punct ",",signals
R2647 T2978 T2990 nmod Hsp90,proteins
R2648 T2825 T2820 cc and,signals
R2649 T2979 T2978 cc and,Hsp90
R2650 T2826 T2820 conj by,signals
R2651 T2827 T2826 pobj control,by
R2652 T2980 T2981 amod other,immunophilins
R2653 T2828 T2827 prep of,control
R2654 T2981 T2978 conj immunophilins,Hsp90
R2655 T2829 T2830 amod nuclear,export
R2656 T2982 T2978 conj [,Hsp90
R2657 T2830 T2828 pobj export,of
R2658 T2983 T2984 nummod 24,]
R2659 T2984 T2978 conj ],Hsp90
R2660 T2831 T2820 prep via,signals
R2661 T2985 T2978 conj [,Hsp90
R2662 T2986 T2987 nummod 26,]
R2663 T2832 T2841 det a,pathway
R2664 T2987 T2990 nmod ],proteins
R2665 T2988 T2987 cc and,]
R2666 T2989 T2990 amod FK506-binding,proteins
R2667 T2833 T2834 amod chromosomal,region
R2668 T2990 T2977 pobj proteins,as
R2669 T2991 T2994 nsubjpass that,linked
R2670 T2992 T2994 aux may,linked
R2671 T2834 T2835 compound region,maintenance
R2672 T2993 T2994 auxpass be,linked
R2673 T2994 T2990 relcl linked,proteins
R2674 T2995 T2996 aux to,dynein
R2675 T2996 T2994 xcomp dynein,linked
R2676 T2835 T2841 nmod maintenance,pathway
R2677 T2997 T2996 cc and/or,dynein
R2678 T2998 T2996 conj peptidylprolyl,dynein
R2679 T2999 T3000 compound isomerase,[
R2680 T3000 T2998 dobj [,peptidylprolyl
R2681 T3001 T3002 nummod 27,]
R2682 T3002 T2998 npadvmod ],peptidylprolyl
R2683 T2836 T2835 nummod 1,maintenance
R2684 T3003 T3002 punct ",",]
R2685 T3004 T3002 appos [,]
R2686 T3005 T3006 nummod 28,]
R2687 T2837 T2835 punct (,maintenance
R2688 T3006 T3002 appos ],]
R2689 T3007 T2962 punct .,are
R2690 T3008 T3021 advmod However,is
R2691 T2838 T2835 appos CRM-1,maintenance
R2692 T3009 T3021 punct ",",is
R2693 T3010 T3012 det the,basis
R2694 T3011 T3012 amod molecular,basis
R2695 T2839 T2835 punct ),maintenance
R2696 T3012 T3021 nsubj basis,is
R2697 T3013 T3012 prep for,basis
R2698 T2840 T2841 amod dependent,pathway
R2699 T3014 T3015 det the,inhibition
R2700 T3015 T3013 pobj inhibition,for
R2701 T2841 T2831 pobj pathway,via
R2702 T2842 T2844 nmod [,]
R2704 T2843 T2844 nummod 21,]
R2780 T3167 T3166 cc and,anti-CD3
R2781 T3168 T3166 conj anti-CD28,anti-CD3
R2782 T3169 T3165 pobj antibodies,by
R2784 T3170 T3164 prep in,activated
R2785 T3171 T3170 pobj vitro,in
R2786 T3172 T3133 punct .,investigated
R2788 T3173 T3175 nsubj We,studied
R2789 T3174 T3175 advmod also,studied
R2790 T3175 T3175 ROOT studied,studied
R2793 T3176 T3177 det the,effects
R2795 T3177 T3175 dobj effects,studied
R2796 T3178 T3177 prep of,effects
R2798 T3179 T3181 amod inhaled,therapy
R2799 T3180 T3181 compound fluticasone,therapy
R2800 T3181 T3178 pobj therapy,of
R2802 T3182 T3181 prep on,therapy
R2803 T3183 T3185 amod GATA-3,localization
R2804 T3184 T3185 amod subcellular,localization
R2806 T3185 T3182 pobj localization,on
R2807 T3186 T3185 prep in,localization
R2808 T3187 T3190 amod peripheral,cells
R2810 T3188 T3189 compound blood,mononuclear
R2811 T3189 T3190 compound mononuclear,cells
R2812 T3190 T3186 pobj cells,in
R2814 T3191 T3192 punct (,PBMCs
R2815 T3192 T3190 appos PBMCs,cells
R2816 T3193 T3192 punct ),PBMCs
R2818 T3194 T3192 prep from,PBMCs
R2819 T3195 T3194 pobj patients,from
R2820 T3196 T3192 prep with,PBMCs
R2822 T3197 T3196 pobj asthma,with
R2823 T3198 T3175 punct .,studied
R2835 T3083 T3085 nummod -13,activity
R2836 T3084 T3085 compound promoter,activity
R2837 T3085 T3079 conj activity,reduced
R2838 T3086 T3085 prep in,activity
R2839 T3087 T3091 amod human,cells
R2840 T3088 T3091 compound CD4,cells
R2841 T3089 T3091 nummod +,cells
R2842 T3090 T3091 compound T,cells
R2843 T3091 T3086 pobj cells,in
R2844 T3092 T3076 punct .,shown
R2845 T3093 T3094 det The,authors
R2846 T3094 T3095 nsubj authors,postulated
R2847 T3095 T3095 ROOT postulated,postulated
R2848 T3096 T3102 mark that,alter
R2881 T3129 T3128 pobj transcription,for
R2882 T3130 T3095 punct .,postulated
R2883 T3131 T3133 nsubj We,investigated
R2884 T3132 T3133 advmod therefore,investigated
R2885 T3133 T3133 ROOT investigated,investigated
R2886 T3134 T3135 det the,effects
R2703 T3016 T3015 prep of,inhibition
R2705 T3017 T3018 amod Th2,cytokines
R2706 T3018 T3016 pobj cytokines,of
R2707 T3038 T3021 advcl have,is
R2708 T3019 T3015 prep by,inhibition
R2709 T3020 T3019 pobj corticosteroids,by
R2710 T3021 T3021 ROOT is,is
R2711 T3022 T3021 neg not,is
R2712 T3039 T3042 det any,sequence
R2713 T3023 T3024 advmod well,understood
R2714 T3024 T3021 acomp understood,is
R2715 T3040 T3042 amod recognisable,sequence
R2716 T3025 T3021 punct ",",is
R2717 T3026 T3038 mark because,have
R2718 T3027 T3028 det the,genes
R2719 T3041 T3042 compound GRE,sequence
R2720 T3028 T3038 nsubj genes,have
R2721 T3029 T3028 acl encoding,genes
R2722 T3030 T3029 dobj IL-4,encoding
R2723 T3042 T3038 dobj sequence,have
R2724 T3031 T3030 punct ",",IL-4
R2725 T3032 T3030 conj IL-5,IL-4
R2726 T3033 T3032 punct ",",IL-5
R2727 T3043 T3045 nmod [,]
R2728 T3034 T3029 cc and,encoding
R2729 T3035 T3038 nsubj IL-13,have
R2730 T3036 T3038 aux do,have
R2731 T3037 T3038 neg not,have
R2732 T3044 T3045 nummod 29,]
R2733 T3045 T3042 appos ],sequence
R2734 T3046 T3038 cc and,have
R2735 T3047 T3050 auxpass are,regulated
R2736 T3048 T3050 advmod only,regulated
R2738 T3049 T3050 advmod partly,regulated
R2741 T3050 T3038 conj regulated,have
R2745 T3051 T3050 agent by,regulated
R2750 T3052 T3051 pobj NF-κB,by
R2753 T3053 T3050 prep in,regulated
R2758 T3054 T3055 amod human,cells
R2762 T3055 T3053 pobj cells,in
R2765 T3056 T3058 nmod [,]
R2769 T3057 T3058 nummod 30,]
R2773 T3058 T3055 appos ],cells
R2776 T3059 T3055 appos [,cells
R2783 T3060 T3061 nummod 32,]
R2787 T3061 T3059 appos ],[
R2791 T3062 T3021 punct .,is
R2792 T3063 T3076 advcl Using,shown
R2794 T3064 T3063 dobj overexpression,Using
R2797 T3065 T3064 cc and,overexpression
R2801 T3066 T3067 amod CAT-reporter,genes
R2805 T3067 T3064 conj genes,overexpression
R2809 T3068 T3067 punct ",",genes
R2813 T3069 T3076 nsubj Lavender,shown
R2817 T3070 T3069 cc and,Lavender
R2821 T3071 T3069 conj colleagues,Lavender
R2824 T3072 T3074 nmod [,]
R2825 T3073 T3074 nummod 33,]
R2826 T3074 T3071 appos ],colleagues
R2827 T3075 T3076 aux have,shown
R2828 T3076 T3076 ROOT shown,shown
R2829 T3077 T3079 mark that,reduced
R2830 T3078 T3079 nsubj GR,reduced
R2831 T3079 T3076 ccomp reduced,shown
R2832 T3080 T3081 amod GATA-3-mediated,IL-5
R2833 T3081 T3079 dobj IL-5,reduced
R2834 T3082 T3079 cc and,reduced
R2849 T3097 T3098 amod local,recruitment
R2850 T3098 T3102 nsubj recruitment,alter
R2851 T3099 T3098 prep of,recruitment
R2852 T3100 T3099 pobj GR,of
R2853 T3101 T3102 aux may,alter
R2854 T3102 T3095 ccomp alter,postulated
R2855 T3103 T3104 det the,ability
R2856 T3104 T3102 dobj ability,alter
R2857 T3105 T3104 prep of,ability
R2858 T3106 T3105 pobj GATA-3,of
R2859 T3107 T3109 preconj either,bind
R2860 T3108 T3109 aux to,bind
R2861 T3109 T3104 conj bind,ability
R2862 T3110 T3102 prep to,alter
R2863 T3111 T3113 poss its,site
R2864 T3112 T3113 compound target,site
R2865 T3113 T3110 pobj site,to
R2866 T3114 T3102 punct ",",alter
R2867 T3115 T3116 aux to,cause
R2868 T3116 T3102 advcl cause,alter
R2869 T3117 T3118 amod transcriptional,up-regulation
R2870 T3118 T3116 dobj up-regulation,cause
R2871 T3119 T3118 punct ",",up-regulation
R2872 T3120 T3116 cc or,cause
R2873 T3121 T3122 aux to,maintain
R2874 T3122 T3116 conj maintain,cause
R2875 T3123 T3124 det an,environment
R2876 T3124 T3122 dobj environment,maintain
R2877 T3125 T3126 nsubj that,is
R2878 T3126 T3124 relcl is,environment
R2879 T3127 T3126 acomp permissive,is
R2880 T3128 T3127 prep for,permissive
R2737 T3135 T3133 dobj effects,investigated
R2739 T3136 T3135 prep of,effects
R2740 T3137 T3139 det a,corticosteroid
R2742 T3138 T3139 amod synthetic,corticosteroid
R2743 T3139 T3136 pobj corticosteroid,of
R2744 T3140 T3139 punct ",",corticosteroid
R2746 T3141 T3139 appos FP,corticosteroid
R2747 T3142 T3139 punct ",",corticosteroid
R2748 T3143 T3135 prep on,effects
R2749 T3144 T3145 amod GATA-3,phosphorylation
R2751 T3145 T3143 pobj phosphorylation,on
R2752 T3146 T3145 cc and,phosphorylation
R2754 T3147 T3148 amod nuclear,translocation
R2755 T3148 T3145 conj translocation,phosphorylation
R2756 T3149 T3135 prep in,effects
R2757 T3150 T3154 det a,line
R2759 T3151 T3154 compound T,line
R2760 T3152 T3154 compound lymphocyte,line
R2761 T3153 T3154 compound cell,line
R2763 T3154 T3149 pobj line,in
R2764 T3155 T3156 punct (,HuT-78
R2766 T3156 T3154 appos HuT-78,line
R2767 T3157 T3156 punct ),HuT-78
R2768 T3158 T3149 cc and,in
R2770 T3159 T3149 conj in,in
R2771 T3160 T3163 amod peripheral,cells
R2772 T3161 T3162 compound blood,mononuclear
R2774 T3162 T3163 compound mononuclear,cells
R2775 T3163 T3159 pobj cells,in
R2777 T3164 T3163 acl activated,cells
R2778 T3165 T3164 agent by,activated
R2779 T3166 T3169 amod anti-CD3,antibodies
R1967 T2279 T2293 nsubjpass Inflammation,mediated
R1968 T2280 T2279 prep in,Inflammation
R1969 T2281 T2282 amod allergic,diseases
R1970 T2282 T2280 pobj diseases,in
R1971 T2283 T2284 amod such,as
R1972 T2284 T2282 prep as,diseases
R1973 T2285 T2284 pobj asthma,as
R1974 T2286 T2285 punct ",",asthma
R1975 T2287 T2285 conj rhinitis,asthma
R1976 T2288 T2287 punct ",",rhinitis
R2339 T2666 T2665 pcomp phosphorylating,in
R2340 T2667 T2666 dobj GATA-3,phosphorylating
R2342 T2668 T2669 aux to,enhance
R2343 T2669 T2661 advcl enhance,plays
R2344 T2670 T2671 poss its,interaction
R2346 T2671 T2669 dobj interaction,enhance
R2347 T2672 T2671 prep with,interaction
R2348 T2673 T2676 amod importin-α,transport
R2349 T2674 T2673 cc and,importin-α
R2351 T2675 T2673 conj subsequent,importin-α
R2352 T2676 T2672 pobj transport,with
R2354 T2677 T2669 prep into,enhance
R2355 T2678 T2679 det the,nucleus
R2356 T2679 T2677 pobj nucleus,into

UBERON-AE

Id Subject Object Predicate Lexical cue
T1179 4845-4850 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1180 5034-5039 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GO-BP

Id Subject Object Predicate Lexical cue
T3229 381-394 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3230 2775-2788 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3231 4650-4663 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3232 487-507 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T3233 581-602 http://purl.obolibrary.org/obo/GO_0006338 denotes chromatin remodelling
T3234 1249-1264 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T3235 1603-1617 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3236 1673-1687 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3237 3815-3829 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3238 1618-1624 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T3239 3057-3064 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T3240 1637-1648 http://purl.obolibrary.org/obo/GO_0006810 denotes transported
T3241 2160-2169 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T3242 1637-1665 http://purl.obolibrary.org/obo/GO_0051169 denotes transported into the nucleus
T3243 2160-2186 http://purl.obolibrary.org/obo/GO_0051169 denotes transport into the nucleus
T3244 1658-1695 http://purl.obolibrary.org/obo/GO_0006606 denotes nucleus by the nuclear import protein
T3245 1681-1695 http://purl.obolibrary.org/obo/GO_0017038 denotes import protein
T3246 1796-1808 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3247 1878-1890 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3248 2930-2942 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3249 2995-3007 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3250 5007-5019 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T3251 1965-1980 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3252 4748-4763 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3253 2010-2013 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T3254 2048-2052 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T3255 2022-2046 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T3256 2022-2046 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T3257 2022-2046 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T3258 2022-2046 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T3259 2525-2548 http://purl.obolibrary.org/obo/GO_0051384 denotes glucocorticoid response
T3260 2947-2956 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T3261 3047-3056 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T3262 3089-3103 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T3263 3783-3793 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3264 4585-4595 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3265 3875-3888 http://purl.obolibrary.org/obo/GO_0003755 denotes immunophilins
T3266 3948-3954 http://purl.obolibrary.org/obo/GO_0003777 denotes dynein
T3267 4292-4295 http://purl.obolibrary.org/obo/GO_0004096 denotes CAT
T3268 4863-4878 http://purl.obolibrary.org/obo/GO_0001775 denotes cells activated
T3225 13-25 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T3226 316-328 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3227 654-666 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3228 2259-2271 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

GO-MF

Id Subject Object Predicate Lexical cue
T3290 3644-3665 http://purl.obolibrary.org/obo/GO_0050693 denotes ligand-binding domain
T3291 3875-3888 http://purl.obolibrary.org/obo/GO_0003755 denotes immunophilins
T3292 3903-3916 http://purl.obolibrary.org/obo/GO_0005528 denotes FK506-binding
T3293 3909-3925 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T3294 3948-3954 http://purl.obolibrary.org/obo/GO_0003777 denotes dynein
T3295 4292-4295 http://purl.obolibrary.org/obo/GO_0004096 denotes CAT
T3296 4905-4915 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T3269 152-157 http://purl.obolibrary.org/obo/GO_0005136 denotes IL)-4
T3270 554-559 http://purl.obolibrary.org/obo/GO_0005136 denotes 4, IL
T3271 4136-4141 http://purl.obolibrary.org/obo/GO_0005136 denotes 4, IL
T3272 159-163 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3273 278-282 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3274 557-561 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3275 4139-4143 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3276 4384-4388 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3277 169-174 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T3278 213-218 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T3279 567-572 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T3280 4149-4154 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T3281 2010-2013 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T3282 2048-2052 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T3283 2022-2046 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T3284 2419-2426 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3285 3651-3658 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3286 3502-3509 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T3287 3644-3650 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T3288 2419-2454 http://purl.obolibrary.org/obo/GO_0035259 denotes binding to glucocorticoid receptors
T3289 2987-3017 http://purl.obolibrary.org/obo/GO_0008139 denotes nuclear localisation sequences

GO-CC

Id Subject Object Predicate Lexical cue
T3311 1851-1856 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3312 4250-4255 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3306 197-202 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3307 450-455 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3308 1139-1144 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3309 1460-1465 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3310 1509-1514 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3313 4431-4436 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3314 4863-4868 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3315 5052-5057 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3316 581-590 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T3317 1295-1304 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T3318 1314-1321 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3319 1658-1665 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3320 2179-2186 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3321 2492-2499 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3322 3479-3486 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3323 2775-2812 http://purl.obolibrary.org/obo/GO_0044798 denotes transcription factors such as nuclear
T3324 3110-3121 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosomal
T3325 3110-3128 http://purl.obolibrary.org/obo/GO_0098687 denotes chromosomal region
T3326 4905-4915 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T3327 4905-4915 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies

sentences

Id Subject Object Predicate Lexical cue
T1295 13-203 Sentence denotes Inflammation in allergic diseases such as asthma, rhinitis, and atopic dermatitis is mediated via expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells.
T1296 204-333 Sentence denotes IL-4 and IL-13 regulate the expression of IgE from B lymphocytes, whereas IL-5 plays a key role in eosinophilic inflammation [1].
T1297 334-464 Sentence denotes Th2 cytokines are regulated by the zinc finger transcription factor GATA-3, which is predominantly expressed in Th2 cells [2],[3].
T1298 465-611 Sentence denotes GATA-3 determines Th2 cell differentiation and selectively activates the promoters of IL-4, IL-5, and IL-13 through chromatin remodelling [4]–[7].
T1299 612-870 Sentence denotes The key role of GATA-3 in allergic airway inflammation has been demonstrated in mice by the reduced release of Th2 cytokines in animals treated with dominant-negative mutants of GATA-3 and by local application of antisense oligonucleotides to GATA-3 [8],[9].
T1300 871-1075 Sentence denotes Furthermore, conditional knock-out of the Gata3 gene in mice reduces expression of Th2 cytokines in vitro and in vivo [10], and similar results have been reported in isolated murine CD4+ lymphocytes [11].
T1301 1076-1216 Sentence denotes Finally, knockdown of GATA-3 expression using siRNA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].
T1302 1217-1349 Sentence denotes In order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes.
T1303 1350-1574 Sentence denotes Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12].
T1304 1575-1742 Sentence denotes GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12].
T1305 1743-1901 Sentence denotes Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14].
T1306 1902-2192 Sentence denotes The affinity of the importin-α–NLS interaction is regulated by phosphorylation [15], and we have shown that p38 mitogen-activated protein kinase (MAPK) plays a critical role in phosphorylating GATA-3 to enhance its interaction with importin-α and subsequent transport into the nucleus [12].
T1307 2193-2354 Sentence denotes Corticosteroids are highly effective in the treatment of allergic inflammation, with marked suppression of Th2 cytokines in airways of patients with asthma [16].
T1308 2355-2616 Sentence denotes Corticosteroids mediate their anti-inflammatory effects through binding to glucocorticoid receptors (GRs), which then translocate to the nucleus where they interact with glucocorticoid response elements (GREs) in the promoter regions of steroid-sensitive genes.
T1309 2617-2921 Sentence denotes Alternatively, activated GR interacts with coactivator molecules to suppress the expression of inflammatory genes by inhibiting the action of proinflammatory transcription factors such as nuclear factor-κB (NF-κB) through the recruitment of co-repressor molecules such as histone deacetylase-2 [17],[18].
T1310 2922-3174 Sentence denotes Nuclear localisation and retention of GR is mediated through the nuclear localisation sequences NL1 and NL2 [19], by nuclear retention signals [20], and by control of nuclear export via a chromosomal region maintenance 1 (CRM-1) dependent pathway [21].
T1311 3175-3239 Sentence denotes NL1, which is similar to the SV40 NLS, binds to importin-α [22].
T1312 3240-3411 Sentence denotes NL1 is activated both by glucocorticoid agonists such as dexamethasone and fluticasone propionate (FP) and by glucocorticoid antagonists such as mifepristone (RU486) [23].
T1313 3412-3604 Sentence denotes NL1 can be mutated, and the resulting GR still translocates to the nucleus in response to ligands, but via interaction with importin 7, an event that requires an as-yet unknown component [23].
T1314 3605-3728 Sentence denotes NL2 is poorly defined, residing in the ligand-binding domain, and much less is known about its mechanism of GR import [24].
T1315 3729-3997 Sentence denotes A variety of other factors are also important for the regulation of GR activation and nuclear import including chaperones such as Hsp90 and other immunophilins [24]–[26] and FK506-binding proteins that may be linked to dynein and/or peptidylprolyl isomerase [27],[28].
T1316 3998-4266 Sentence denotes However, the molecular basis for the inhibition of Th2 cytokines by corticosteroids is not well understood, because the genes encoding IL-4, IL-5, and IL-13 do not have any recognisable GRE sequence [29] and are only partly regulated by NF-κB in human cells [30]–[32].
T1317 4267-4437 Sentence denotes Using overexpression and CAT-reporter genes, Lavender and colleagues [33] have shown that GR reduced GATA-3-mediated IL-5 and -13 promoter activity in human CD4+ T cells.
T1318 4438-4664 Sentence denotes The authors postulated that local recruitment of GR may alter the ability of GATA-3 either to bind to its target site, to cause transcriptional up-regulation, or to maintain an environment that is permissive for transcription.
T1319 4665-4925 Sentence denotes We therefore investigated the effects of a synthetic corticosteroid, FP, on GATA-3 phosphorylation and nuclear translocation in a T lymphocyte cell line (HuT-78) and in peripheral blood mononuclear cells activated by anti-CD3 and anti-CD28 antibodies in vitro.
T1320 4926-5092 Sentence denotes We also studied the effects of inhaled fluticasone therapy on GATA-3 subcellular localization in peripheral blood mononuclear cells (PBMCs) from patients with asthma.
T51 0-12 Sentence denotes Introduction
T52 13-203 Sentence denotes Inflammation in allergic diseases such as asthma, rhinitis, and atopic dermatitis is mediated via expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells.
T53 204-333 Sentence denotes IL-4 and IL-13 regulate the expression of IgE from B lymphocytes, whereas IL-5 plays a key role in eosinophilic inflammation [1].
T54 334-464 Sentence denotes Th2 cytokines are regulated by the zinc finger transcription factor GATA-3, which is predominantly expressed in Th2 cells [2],[3].
T55 465-611 Sentence denotes GATA-3 determines Th2 cell differentiation and selectively activates the promoters of IL-4, IL-5, and IL-13 through chromatin remodelling [4]–[7].
T56 612-870 Sentence denotes The key role of GATA-3 in allergic airway inflammation has been demonstrated in mice by the reduced release of Th2 cytokines in animals treated with dominant-negative mutants of GATA-3 and by local application of antisense oligonucleotides to GATA-3 [8],[9].
T57 871-1075 Sentence denotes Furthermore, conditional knock-out of the Gata3 gene in mice reduces expression of Th2 cytokines in vitro and in vivo [10], and similar results have been reported in isolated murine CD4+ lymphocytes [11].
T58 1076-1216 Sentence denotes Finally, knockdown of GATA-3 expression using siRNA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].
T59 1217-1349 Sentence denotes In order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes.
T60 1350-1574 Sentence denotes Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12].
T61 1575-1742 Sentence denotes GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12].
T62 1743-1901 Sentence denotes Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14].
T63 1902-2192 Sentence denotes The affinity of the importin-α–NLS interaction is regulated by phosphorylation [15], and we have shown that p38 mitogen-activated protein kinase (MAPK) plays a critical role in phosphorylating GATA-3 to enhance its interaction with importin-α and subsequent transport into the nucleus [12].
T64 2193-2354 Sentence denotes Corticosteroids are highly effective in the treatment of allergic inflammation, with marked suppression of Th2 cytokines in airways of patients with asthma [16].
T65 2355-2616 Sentence denotes Corticosteroids mediate their anti-inflammatory effects through binding to glucocorticoid receptors (GRs), which then translocate to the nucleus where they interact with glucocorticoid response elements (GREs) in the promoter regions of steroid-sensitive genes.
T66 2617-2921 Sentence denotes Alternatively, activated GR interacts with coactivator molecules to suppress the expression of inflammatory genes by inhibiting the action of proinflammatory transcription factors such as nuclear factor-κB (NF-κB) through the recruitment of co-repressor molecules such as histone deacetylase-2 [17],[18].
T67 2922-3174 Sentence denotes Nuclear localisation and retention of GR is mediated through the nuclear localisation sequences NL1 and NL2 [19], by nuclear retention signals [20], and by control of nuclear export via a chromosomal region maintenance 1 (CRM-1) dependent pathway [21].
T68 3175-3239 Sentence denotes NL1, which is similar to the SV40 NLS, binds to importin-α [22].
T69 3240-3411 Sentence denotes NL1 is activated both by glucocorticoid agonists such as dexamethasone and fluticasone propionate (FP) and by glucocorticoid antagonists such as mifepristone (RU486) [23].
T70 3412-3604 Sentence denotes NL1 can be mutated, and the resulting GR still translocates to the nucleus in response to ligands, but via interaction with importin 7, an event that requires an as-yet unknown component [23].
T71 3605-3728 Sentence denotes NL2 is poorly defined, residing in the ligand-binding domain, and much less is known about its mechanism of GR import [24].
T72 3729-3997 Sentence denotes A variety of other factors are also important for the regulation of GR activation and nuclear import including chaperones such as Hsp90 and other immunophilins [24]–[26] and FK506-binding proteins that may be linked to dynein and/or peptidylprolyl isomerase [27],[28].
T73 3998-4266 Sentence denotes However, the molecular basis for the inhibition of Th2 cytokines by corticosteroids is not well understood, because the genes encoding IL-4, IL-5, and IL-13 do not have any recognisable GRE sequence [29] and are only partly regulated by NF-κB in human cells [30]–[32].
T74 4267-4437 Sentence denotes Using overexpression and CAT-reporter genes, Lavender and colleagues [33] have shown that GR reduced GATA-3-mediated IL-5 and -13 promoter activity in human CD4+ T cells.
T75 4438-4664 Sentence denotes The authors postulated that local recruitment of GR may alter the ability of GATA-3 either to bind to its target site, to cause transcriptional up-regulation, or to maintain an environment that is permissive for transcription.
T76 4665-4925 Sentence denotes We therefore investigated the effects of a synthetic corticosteroid, FP, on GATA-3 phosphorylation and nuclear translocation in a T lymphocyte cell line (HuT-78) and in peripheral blood mononuclear cells activated by anti-CD3 and anti-CD28 antibodies in vitro.
T77 4926-5092 Sentence denotes We also studied the effects of inhaled fluticasone therapy on GATA-3 subcellular localization in peripheral blood mononuclear cells (PBMCs) from patients with asthma.

ICD10

Id Subject Object Predicate Lexical cue
T3297 55-61 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T3298 2342-2348 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T3299 5085-5091 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T3300 55-61 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3301 2342-2348 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3302 5085-5091 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3303 77-94 http://purl.bioontology.org/ontology/ICD10/L20 denotes atopic dermatitis
T3304 77-94 http://purl.bioontology.org/ontology/ICD10/L20.9 denotes atopic dermatitis
T3305 84-94 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis

events-check-again

Id Subject Object Predicate Lexical cue Speculation
T3556 139-157 Protein denotes interleukin (IL)-4
T3557 159-163 Protein denotes IL-5
T3558 169-174 Protein denotes IL-13
T3559 204-208 Protein denotes IL-4
T3560 213-218 Protein denotes IL-13
T3561 278-282 Protein denotes IL-5
T3562 402-408 Protein denotes GATA-3
T3563 433-442 Gene_expression denotes expressed
T3564 465-471 Protein denotes GATA-3
T3565 524-533 Positive_regulation denotes activates
T3566 524-533 Positive_regulation denotes activates
T3567 524-533 Positive_regulation denotes activates
T3568 538-547 Entity denotes promoters
T3569 551-555 Protein denotes IL-4
T3570 557-561 Protein denotes IL-5
T3571 567-572 Protein denotes IL-13
T3572 628-634 Protein denotes GATA-3
T3573 790-796 Protein denotes GATA-3
T3574 855-861 Protein denotes GATA-3
T3575 913-918 Protein denotes Gata3
T3576 1053-1056 Protein denotes CD4
T3577 1085-1094 Negative_regulation denotes knockdown
T3578 1098-1104 Protein denotes GATA-3
T3579 1105-1115 Gene_expression denotes expression
T3580 1230-1236 Protein denotes GATA-3
T3581 1274-1285 Localization denotes translocate
T3582 1314-1321 Entity denotes nucleus
T3583 1325-1331 Binding denotes access
T3584 1336-1342 Binding denotes target
T3585 1359-1366 Entity denotes nuclear
T3586 1367-1377 Localization denotes expression
T3587 1381-1387 Protein denotes GATA-3
T3588 1388-1397 Positive_regulation denotes following
T3589 1515-1524 Positive_regulation denotes following
T3590 1575-1581 Protein denotes GATA-3
T3591 1637-1648 Localization denotes transported
T3592 1658-1665 Entity denotes nucleus
T3593 1781-1787 Protein denotes GATA-3
T3594 2071-2075 Regulation denotes role
T3595 2079-2094 Phosphorylation denotes phosphorylating
T3596 2095-2101 Protein denotes GATA-3
T3597 2105-2112 Positive_regulation denotes enhance
T3598 2117-2128 Binding denotes interaction
T3599 2419-2426 Binding denotes binding
T3600 2430-2454 Protein denotes glucocorticoid receptors
T3601 2456-2459 Protein denotes GRs
T3602 2473-2484 Localization denotes translocate
T3603 2492-2499 Entity denotes nucleus
T3604 2511-2519 Binding denotes interact
T3605 2632-2641 Positive_regulation denotes activated
T3606 2642-2644 Protein denotes GR
T3607 2645-2654 Binding denotes interacts
T3608 2843-2854 Binding denotes recruitment
T3609 2889-2910 Protein denotes histone deacetylase-2
T3610 2922-2929 Entity denotes Nuclear
T3611 2930-2942 Localization denotes localisation
T3612 2947-2956 Localization denotes retention
T3613 2960-2962 Protein denotes GR
T3614 2966-2974 Positive_regulation denotes mediated
T3615 2966-2974 Positive_regulation denotes mediated
T3616 3078-3085 Regulation denotes control
T3617 3089-3096 Entity denotes nuclear
T3618 3097-3103 Localization denotes export
T3619 3110-3142 Protein denotes chromosomal region maintenance 1
T3620 3144-3149 Protein denotes CRM-1
T3621 3151-3160 Regulation denotes dependent
T3622 3175-3178 Entity denotes NL1
T3623 3214-3219 Binding denotes binds
T3624 3440-3449 Regulation denotes resulting
T3625 3450-3452 Protein denotes GR
T3626 3459-3471 Localization denotes translocates
T3627 3479-3486 Entity denotes nucleus
T3628 3487-3501 Positive_regulation denotes in response to
T3629 3519-3530 Binding denotes interaction
T3630 3536-3546 Protein denotes importin 7
T3631 3562-3570 Positive_regulation denotes requires
T3632 3713-3715 Protein denotes GR
T3633 3716-3722 Localization denotes import
T3634 3765-3774 Regulation denotes important
T3635 3783-3793 Regulation denotes regulation
T3636 3797-3799 Protein denotes GR
T3637 3800-3810 Positive_regulation denotes activation
T3638 4133-4137 Protein denotes IL-4
T3639 4139-4143 Protein denotes IL-5
T3640 4149-4154 Protein denotes IL-13
T3641 4222-4231 Regulation denotes regulated
T3642 4222-4231 Regulation denotes regulated
T3643 4222-4231 Regulation denotes regulated
T3644 4292-4295 Protein denotes CAT
T3645 4357-4359 Protein denotes GR
T3646 4360-4367 Negative_regulation denotes reduced
T3647 4360-4367 Negative_regulation denotes reduced
T3648 4368-4374 Protein denotes GATA-3
T3649 4375-4383 Positive_regulation denotes mediated
T3650 4375-4383 Positive_regulation denotes mediated
T3651 4384-4388 Protein denotes IL-5
T3652 4393-4396 Protein denotes -13
T3653 4406-4414 Gene_expression denotes activity
T3654 4406-4414 Gene_expression denotes activity
T3655 4424-4427 Protein denotes CD4
T3656 4472-4483 Localization denotes recruitment
T3657 4487-4489 Protein denotes GR
T3658 4494-4499 Regulation denotes alter true
T3659 4515-4521 Protein denotes GATA-3
T3660 4532-4536 Binding denotes bind
T3661 4695-4702 Regulation denotes effects true
T3662 4695-4702 Regulation denotes effects true
T3663 4741-4747 Protein denotes GATA-3
T3664 4748-4763 Phosphorylation denotes phosphorylation
T3665 4768-4775 Entity denotes nuclear
T3666 4776-4789 Localization denotes translocation
T3667 4946-4953 Regulation denotes effects
T3668 4988-4994 Protein denotes GATA-3
T3669 5007-5019 Localization denotes localization
R3043 T3562 T3563 themeOf GATA-3,expressed
R3044 T3564 T3566 causeOf GATA-3,activates
R3045 T3564 T3567 causeOf GATA-3,activates
R3046 T3564 T3565 causeOf GATA-3,activates
R3049 T3568 T3566 themeOf promoters,activates
R3050 T3568 T3570 partOf promoters,IL-5
R3051 T3568 T3567 themeOf promoters,activates
R3052 T3568 T3569 partOf promoters,IL-4
R3053 T3568 T3565 themeOf promoters,activates
R3054 T3568 T3571 partOf promoters,IL-13
R3059 T3578 T3579 themeOf GATA-3,expression
R3060 T3579 T3577 themeOf expression,knockdown
R3062 T3580 T3581 themeOf GATA-3,translocate
R3063 T3580 T3583 themeOf GATA-3,access
R3064 T3580 T3584 themeOf GATA-3,target
R3065 T3582 T3581 locationOf nucleus,translocate
R3069 T3585 T3586 locationOf nuclear,expression
R3070 T3586 T3588 themeOf expression,following
R3071 T3586 T3589 themeOf expression,following
R3073 T3587 T3586 themeOf GATA-3,expression
R3075 T3590 T3591 themeOf GATA-3,transported
R3076 T3592 T3591 locationOf nucleus,transported
R3079 T3595 T3594 themeOf phosphorylating,role
R3080 T3595 T3597 causeOf phosphorylating,enhance
R3081 T3596 T3595 themeOf GATA-3,phosphorylating
R3082 T3596 T3598 themeOf GATA-3,interaction
R3084 T3598 T3597 themeOf interaction,enhance
R3085 T3600 T3599 themeOf glucocorticoid receptors,binding
R3086 T3600 T3602 themeOf glucocorticoid receptors,translocate
R3087 T3600 T3604 themeOf glucocorticoid receptors,interact
R3089 T3601 T3600 equivalentTo GRs,glucocorticoid receptors
R3091 T3603 T3602 locationOf nucleus,translocate
R3092 T3606 T3605 themeOf GR,activated
R3093 T3606 T3607 themeOf GR,interacts
R3094 T3606 T3608 themeOf GR,recruitment
R3096 T3609 T3608 themeOf histone deacetylase-2,recruitment
R3097 T3610 T3611 locationOf Nuclear,localisation
R3098 T3611 T3615 themeOf localisation,mediated
R3099 T3612 T3614 themeOf retention,mediated
R3100 T3613 T3611 themeOf GR,localisation
R3101 T3613 T3612 themeOf GR,retention
R3102 T3613 T3618 themeOf GR,export
R3103 T3616 T3615 causeOf control,mediated
R3104 T3616 T3614 causeOf control,mediated
R3105 T3616 T3621 themeOf control,dependent
R3106 T3617 T3618 locationOf nuclear,export
R3107 T3618 T3616 themeOf export,control
R3108 T3619 T3621 causeOf chromosomal region maintenance 1,dependent
R3109 T3620 T3619 equivalentTo CRM-1,chromosomal region maintenance 1
R3110 T3622 T3623 themeOf NL1,binds
R3111 T3622 T3613 partOf NL1,GR
R3112 T3625 T3626 themeOf GR,translocates
R3113 T3625 T3629 themeOf GR,interaction
R3114 T3626 T3624 themeOf translocates,resulting
R3115 T3626 T3628 themeOf translocates,in response to
R3116 T3627 T3626 locationOf nucleus,translocates
R3117 T3629 T3628 causeOf interaction,in response to
R3118 T3629 T3631 themeOf interaction,requires
R3119 T3630 T3629 themeOf importin 7,interaction
R3120 T3632 T3633 themeOf GR,import
R3121 T3635 T3634 themeOf regulation,important
R3122 T3636 T3637 themeOf GR,activation
R3123 T3637 T3635 themeOf activation,regulation
R3124 T3638 T3641 themeOf IL-4,regulated
R3125 T3639 T3643 themeOf IL-5,regulated
R3126 T3640 T3642 themeOf IL-13,regulated
R3127 T3645 T3646 causeOf GR,reduced
R3128 T3645 T3647 causeOf GR,reduced
R3129 T3648 T3649 causeOf GATA-3,mediated
R3130 T3648 T3650 causeOf GATA-3,mediated
R3131 T3649 T3646 themeOf mediated,reduced
R3132 T3650 T3647 themeOf mediated,reduced
R3133 T3651 T3653 themeOf IL-5,activity
R3134 T3652 T3654 themeOf -13,activity
R3135 T3653 T3649 themeOf activity,mediated
R3136 T3654 T3650 themeOf activity,mediated
R3137 T3656 T3658 causeOf recruitment,alter
R3138 T3657 T3656 themeOf GR,recruitment
R3139 T3659 T3660 themeOf GATA-3,bind
R3140 T3660 T3658 themeOf bind,alter
R3141 T3663 T3664 themeOf GATA-3,phosphorylation
R3142 T3663 T3666 themeOf GATA-3,translocation
R3143 T3664 T3662 themeOf phosphorylation,effects
R3144 T3665 T3666 locationOf nuclear,translocation
R3145 T3666 T3661 themeOf translocation,effects
R3146 T3668 T3669 themeOf GATA-3,localization
R3147 T3669 T3667 themeOf localization,effects

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Speculation
T1201 1053-1056 Protein denotes CD4
T1202 1085-1094 Negative_regulation denotes knockdown
T1203 1098-1104 Protein denotes GATA-3
T1204 1105-1115 Gene_expression denotes expression
T1205 1230-1236 Protein denotes GATA-3
T1206 1274-1285 Localization denotes translocate
T1207 1314-1321 Entity denotes nucleus
T1208 1325-1331 Binding denotes access
T1209 1336-1342 Binding denotes target
T1210 1359-1366 Entity denotes nuclear
T1211 1367-1377 Localization denotes expression
T1212 1381-1387 Protein denotes GATA-3
T1213 1388-1397 Positive_regulation denotes following
T1214 1515-1524 Positive_regulation denotes following
T1215 1575-1581 Protein denotes GATA-3
T1216 1637-1648 Localization denotes transported
T1217 1658-1665 Entity denotes nucleus
T1218 1781-1787 Protein denotes GATA-3
T1219 2071-2075 Regulation denotes role
T1220 2079-2094 Phosphorylation denotes phosphorylating
T1221 2095-2101 Protein denotes GATA-3
T1222 2105-2112 Positive_regulation denotes enhance
T1223 2117-2128 Binding denotes interaction
T1224 2419-2426 Binding denotes binding
T1225 2430-2454 Protein denotes glucocorticoid receptors
T1226 2456-2459 Protein denotes GRs
T1227 2473-2484 Localization denotes translocate
T1228 2492-2499 Entity denotes nucleus
T1229 2511-2519 Binding denotes interact
T1256 3562-3570 Positive_regulation denotes requires
T1257 3713-3715 Protein denotes GR
T1258 3716-3722 Localization denotes import
T1259 3765-3774 Regulation denotes important
T1260 3783-3793 Regulation denotes regulation
T1261 3797-3799 Protein denotes GR
T1262 3800-3810 Positive_regulation denotes activation
T1263 4133-4137 Protein denotes IL-4
T1264 4139-4143 Protein denotes IL-5
T1265 4149-4154 Protein denotes IL-13
T1266 4222-4231 Regulation denotes regulated
T1267 4222-4231 Regulation denotes regulated
T1268 4222-4231 Regulation denotes regulated
T1269 4292-4295 Protein denotes CAT
T1270 4357-4359 Protein denotes GR
T1271 4360-4367 Negative_regulation denotes reduced
T1272 4360-4367 Negative_regulation denotes reduced
T1273 4368-4374 Protein denotes GATA-3
T1274 4375-4383 Positive_regulation denotes mediated
T1275 4375-4383 Positive_regulation denotes mediated
T1276 4384-4388 Protein denotes IL-5
T1277 4393-4396 Protein denotes -13
T1278 4406-4414 Gene_expression denotes activity
T1279 4406-4414 Gene_expression denotes activity
T1280 4424-4427 Protein denotes CD4
T1281 4472-4483 Localization denotes recruitment
T1282 4487-4489 Protein denotes GR
T1283 4494-4499 Regulation denotes alter true
T1284 4515-4521 Protein denotes GATA-3
T1285 4532-4536 Binding denotes bind
T1286 4695-4702 Regulation denotes effects true
T1287 4695-4702 Regulation denotes effects true
T1288 4741-4747 Protein denotes GATA-3
T1289 4748-4763 Phosphorylation denotes phosphorylation
T1290 4768-4775 Entity denotes nuclear
T1291 4776-4789 Localization denotes translocation
T1292 4946-4953 Regulation denotes effects
T1293 4988-4994 Protein denotes GATA-3
T1294 5007-5019 Localization denotes localization
T1181 139-157 Protein denotes interleukin (IL)-4
T1182 159-163 Protein denotes IL-5
T1183 169-174 Protein denotes IL-13
T1184 204-208 Protein denotes IL-4
T1185 213-218 Protein denotes IL-13
T1186 278-282 Protein denotes IL-5
T1187 402-408 Protein denotes GATA-3
T1188 433-442 Gene_expression denotes expressed
T1189 465-471 Protein denotes GATA-3
T1190 524-533 Positive_regulation denotes activates
T1191 524-533 Positive_regulation denotes activates
T1192 524-533 Positive_regulation denotes activates
T1193 538-547 Entity denotes promoters
T1194 551-555 Protein denotes IL-4
T1195 557-561 Protein denotes IL-5
T1196 567-572 Protein denotes IL-13
T1197 628-634 Protein denotes GATA-3
T1198 790-796 Protein denotes GATA-3
T1199 855-861 Protein denotes GATA-3
T1200 913-918 Protein denotes Gata3
T1230 2632-2641 Positive_regulation denotes activated
T1231 2642-2644 Protein denotes GR
T1232 2645-2654 Binding denotes interacts
T1233 2843-2854 Binding denotes recruitment
T1234 2889-2910 Protein denotes histone deacetylase-2
T1235 2922-2929 Entity denotes Nuclear
T1236 2930-2942 Localization denotes localisation
T1237 2947-2956 Localization denotes retention
T1238 2960-2962 Protein denotes GR
T1239 2966-2974 Positive_regulation denotes mediated
T1240 2966-2974 Positive_regulation denotes mediated
T1241 3078-3085 Regulation denotes control
T1242 3089-3096 Entity denotes nuclear
T1243 3097-3103 Localization denotes export
T1244 3110-3142 Protein denotes chromosomal region maintenance 1
T1245 3144-3149 Protein denotes CRM-1
T1246 3151-3160 Regulation denotes dependent
T1247 3175-3178 Entity denotes NL1
T1248 3214-3219 Binding denotes binds
T1249 3440-3449 Regulation denotes resulting
T1250 3450-3452 Protein denotes GR
T1251 3459-3471 Localization denotes translocates
T1252 3479-3486 Entity denotes nucleus
T1253 3487-3501 Positive_regulation denotes in response to
T1254 3519-3530 Binding denotes interaction
T1255 3536-3546 Protein denotes importin 7
R970 T1204 T1202 themeOf expression,knockdown
R971 T1205 T1206 themeOf GATA-3,translocate
R972 T1205 T1208 themeOf GATA-3,access
R973 T1205 T1209 themeOf GATA-3,target
R974 T1207 T1206 locationOf nucleus,translocate
R975 T1210 T1211 locationOf nuclear,expression
R976 T1211 T1213 themeOf expression,following
R977 T1211 T1214 themeOf expression,following
R978 T1212 T1211 themeOf GATA-3,expression
R979 T1215 T1216 themeOf GATA-3,transported
R980 T1217 T1216 locationOf nucleus,transported
R981 T1220 T1219 themeOf phosphorylating,role
R982 T1220 T1222 causeOf phosphorylating,enhance
R983 T1221 T1220 themeOf GATA-3,phosphorylating
R984 T1221 T1223 themeOf GATA-3,interaction
R985 T1223 T1222 themeOf interaction,enhance
R986 T1225 T1224 themeOf glucocorticoid receptors,binding
R987 T1225 T1227 themeOf glucocorticoid receptors,translocate
R988 T1225 T1229 themeOf glucocorticoid receptors,interact
R989 T1226 T1225 equivalentTo GRs,glucocorticoid receptors
R990 T1228 T1227 locationOf nucleus,translocate
R991 T1231 T1230 themeOf GR,activated
R992 T1231 T1232 themeOf GR,interacts
R993 T1231 T1233 themeOf GR,recruitment
R994 T1234 T1233 themeOf histone deacetylase-2,recruitment
R995 T1235 T1236 locationOf Nuclear,localisation
R996 T1236 T1240 themeOf localisation,mediated
R997 T1237 T1239 themeOf retention,mediated
R998 T1238 T1236 themeOf GR,localisation
R999 T1238 T1237 themeOf GR,retention
R1000 T1238 T1243 themeOf GR,export
R1001 T1241 T1240 causeOf control,mediated
R1002 T1241 T1239 causeOf control,mediated
R1003 T1241 T1246 themeOf control,dependent
R1004 T1242 T1243 locationOf nuclear,export
R1005 T1243 T1241 themeOf export,control
R1006 T1244 T1246 causeOf chromosomal region maintenance 1,dependent
R1007 T1245 T1244 equivalentTo CRM-1,chromosomal region maintenance 1
R1008 T1247 T1248 themeOf NL1,binds
R1009 T1247 T1238 partOf NL1,GR
R1010 T1250 T1251 themeOf GR,translocates
R1011 T1250 T1254 themeOf GR,interaction
R1012 T1251 T1249 themeOf translocates,resulting
R1013 T1251 T1253 themeOf translocates,in response to
R1014 T1252 T1251 locationOf nucleus,translocates
R1015 T1254 T1253 causeOf interaction,in response to
R1016 T1254 T1256 themeOf interaction,requires
R1017 T1255 T1254 themeOf importin 7,interaction
R1018 T1257 T1258 themeOf GR,import
R1019 T1260 T1259 themeOf regulation,important
R1020 T1261 T1262 themeOf GR,activation
R1021 T1262 T1260 themeOf activation,regulation
R1022 T1263 T1266 themeOf IL-4,regulated
R1023 T1264 T1268 themeOf IL-5,regulated
R1024 T1265 T1267 themeOf IL-13,regulated
R1025 T1270 T1271 causeOf GR,reduced
R1026 T1270 T1272 causeOf GR,reduced
R1027 T1273 T1274 causeOf GATA-3,mediated
R1028 T1273 T1275 causeOf GATA-3,mediated
R1029 T1274 T1271 themeOf mediated,reduced
R1030 T1275 T1272 themeOf mediated,reduced
R1031 T1276 T1278 themeOf IL-5,activity
R1032 T1277 T1279 themeOf -13,activity
R1033 T1278 T1274 themeOf activity,mediated
R1034 T1279 T1275 themeOf activity,mediated
R1035 T1281 T1283 causeOf recruitment,alter
R1036 T1282 T1281 themeOf GR,recruitment
R1037 T1284 T1285 themeOf GATA-3,bind
R1038 T1285 T1283 themeOf bind,alter
R1039 T1288 T1289 themeOf GATA-3,phosphorylation
R1040 T1288 T1291 themeOf GATA-3,translocation
R1041 T1289 T1287 themeOf phosphorylation,effects
R1042 T1290 T1291 locationOf nuclear,translocation
R1043 T1291 T1286 themeOf translocation,effects
R1044 T1293 T1294 themeOf GATA-3,localization
R1045 T1294 T1292 themeOf localization,effects
R959 T1187 T1188 themeOf GATA-3,expressed
R960 T1189 T1191 causeOf GATA-3,activates
R961 T1189 T1192 causeOf GATA-3,activates
R962 T1189 T1190 causeOf GATA-3,activates
R963 T1193 T1191 themeOf promoters,activates
R964 T1193 T1195 partOf promoters,IL-5
R965 T1193 T1192 themeOf promoters,activates
R966 T1193 T1194 partOf promoters,IL-4
R967 T1193 T1190 themeOf promoters,activates
R968 T1193 T1196 partOf promoters,IL-13
R969 T1203 T1204 themeOf GATA-3,expression

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T2224 159-163 P05113 denotes IL-5
T2225 169-174 P35225 denotes IL-13
T2226 204-208 P05112 denotes IL-4
T2227 213-218 P35225 denotes IL-13
T2228 278-282 P05113 denotes IL-5
T2229 402-408 P23771 denotes GATA-3
T2230 465-471 P23771 denotes GATA-3
T2231 551-555 P05112 denotes IL-4
T2232 557-561 P05113 denotes IL-5
T2233 567-572 P35225 denotes IL-13
T2234 628-634 P23771 denotes GATA-3
T2235 790-796 P23771 denotes GATA-3
T2236 855-861 P23771 denotes GATA-3
T2237 913-918 P23771 denotes Gata3
T2238 1053-1056 P01730 denotes CD4
T2239 1098-1104 P23771 denotes GATA-3
T2240 1169-1172 P09693 denotes CD3
T2241 1169-1172 P20963 denotes CD3
T2242 1169-1172 P04234 denotes CD3
T2243 1169-1172 P07766 denotes CD3
T2244 1173-1177 P10747 denotes CD28
T2245 1230-1236 P23771 denotes GATA-3
T2246 1381-1387 P23771 denotes GATA-3
T2247 1575-1581 P23771 denotes GATA-3
T2248 1781-1787 P23771 denotes GATA-3
T2249 2010-2013 Q16539 denotes p38
T2250 2010-2013 P53778 denotes p38
T2251 2010-2013 Q15759 denotes p38
T2252 2010-2013 O15264 denotes p38
T2253 2014-2046 P28482 denotes mitogen-activated protein kinase
T2254 2014-2046 P27361 denotes mitogen-activated protein kinase
T2255 2095-2101 P23771 denotes GATA-3
T2256 2430-2454 P04150 denotes glucocorticoid receptors
T2257 2456-2459 P04150 denotes GRs
T2258 2642-2644 P04150 denotes GR
T2259 2960-2962 P04150 denotes GR
T2260 3450-3452 P04150 denotes GR
T2261 3713-3715 P04150 denotes GR
T2262 3797-3799 P04150 denotes GR
T2263 4133-4137 P05112 denotes IL-4
T2264 4139-4143 P05113 denotes IL-5
T2265 4149-4154 P35225 denotes IL-13
T2266 4357-4359 P04150 denotes GR
T2267 4368-4374 P23771 denotes GATA-3
T2268 4384-4388 P05113 denotes IL-5
T2269 4424-4427 P01730 denotes CD4
T2270 4487-4489 P04150 denotes GR
T2271 4515-4521 P23771 denotes GATA-3
T2272 4741-4747 P23771 denotes GATA-3
T2273 4887-4890 P07766 denotes CD3
T2274 4887-4890 P09693 denotes CD3
T2275 4887-4890 P04234 denotes CD3
T2276 4887-4890 P20963 denotes CD3
T2277 4900-4904 P10747 denotes CD28
T2278 4988-4994 P23771 denotes GATA-3

test2

Id Subject Object Predicate Lexical cue Speculation
T1071 111-121 Gene_expression denotes expression
T1072 139-157 Protein denotes interleukin (IL)-4
T1073 159-163 Protein denotes IL-5
T1074 169-174 Protein denotes IL-13
T1075 204-208 Protein denotes IL-4
T1076 213-218 Protein denotes IL-13
T1077 219-227 Regulation denotes regulate
T1078 232-242 Gene_expression denotes expression
T1079 278-282 Protein denotes IL-5
T1080 352-361 Regulation denotes regulated
T1081 402-408 Protein denotes GATA-3
T1082 433-442 Gene_expression denotes expressed
T1083 465-471 Protein denotes GATA-3
T1084 524-533 Positive_regulation denotes activates
T1085 538-547 Entity denotes promoters
T1086 551-555 Protein denotes IL-4
T1087 557-561 Protein denotes IL-5
T1088 567-572 Protein denotes IL-13
T1089 628-634 Protein denotes GATA-3
T1090 761-770 Negative_regulation denotes dominant-
T1091 790-796 Protein denotes GATA-3
T1092 855-861 Protein denotes GATA-3
T1093 913-918 Protein denotes Gata3
T1094 1053-1056 Protein denotes CD4
T1095 1085-1094 Negative_regulation denotes knockdown
T1096 1098-1104 Protein denotes GATA-3
T1097 1105-1115 Gene_expression denotes expression
T1098 1230-1236 Protein denotes GATA-3
T1099 1274-1285 Localization denotes translocate
T1100 1314-1321 Entity denotes nucleus
T1101 1350-1358 Positive_regulation denotes Enhanced
T1102 1359-1366 Entity denotes nuclear
T1103 1367-1377 Localization denotes expression
T1104 1381-1387 Protein denotes GATA-3
T1105 1388-1397 Positive_regulation denotes following
T1106 1414-1424 Positive_regulation denotes activation
T1107 1575-1581 Protein denotes GATA-3
T1108 1611-1617 Localization denotes import
T1109 1658-1665 Entity denotes nucleus
T1110 1681-1687 Localization denotes import
T1111 1781-1787 Protein denotes GATA-3
T1112 1952-1961 Regulation denotes regulated
T1113 1965-1980 Phosphorylation denotes phosphorylation
T1114 2071-2075 Regulation denotes role
T1115 2079-2094 Phosphorylation denotes phosphorylating
T1116 2095-2101 Protein denotes GATA-3
T1117 2105-2112 Positive_regulation denotes enhance
T1118 2117-2128 Binding denotes interaction
T1119 2419-2426 Binding denotes binding
T1120 2430-2454 Protein denotes glucocorticoid receptors
T1121 2456-2459 Protein denotes GRs true
T1122 2473-2484 Localization denotes translocate
T1123 2492-2499 Entity denotes nucleus true
T1124 2511-2519 Binding denotes interact
T1125 2632-2641 Positive_regulation denotes activated true
T1126 2642-2644 Protein denotes GR
T1127 2645-2654 Binding denotes interacts
T1128 2843-2854 Binding denotes recruitment
T1129 2889-2910 Protein denotes histone deacetylase-2
T1130 2922-2929 Entity denotes Nuclear
T1131 2930-2942 Localization denotes localisation
T1132 2947-2956 Localization denotes retention
T1133 2960-2962 Protein denotes GR
T1134 2966-2974 Positive_regulation denotes mediated
T1135 3047-3056 Localization denotes retention
T1136 3089-3096 Entity denotes nuclear
T1137 3097-3103 Localization denotes export
T1138 3110-3142 Protein denotes chromosomal region maintenance 1
T1139 3144-3149 Protein denotes CRM-1
T1140 3214-3219 Binding denotes binds
T1141 3440-3449 Positive_regulation denotes resulting
T1142 3450-3452 Protein denotes GR
T1143 3459-3471 Localization denotes translocates
T1144 3479-3486 Entity denotes nucleus
T1145 3487-3501 Positive_regulation denotes in response to
T1146 3519-3530 Binding denotes interaction
T1147 3536-3546 Protein denotes importin 7
T1148 3713-3715 Protein denotes GR
T1149 3716-3722 Localization denotes import
T1150 3783-3793 Regulation denotes regulation
T1151 3797-3799 Protein denotes GR
T1152 3800-3810 Positive_regulation denotes activation
T1153 3815-3822 Entity denotes nuclear
T1154 3823-3829 Localization denotes import
T1155 3909-3916 Binding denotes binding
T1156 4133-4137 Protein denotes IL-4
T1157 4139-4143 Protein denotes IL-5
T1158 4149-4154 Protein denotes IL-13
T1159 4292-4295 Protein denotes CAT
T1160 4357-4359 Protein denotes GR
T1161 4360-4367 Negative_regulation denotes reduced
T1162 4368-4374 Protein denotes GATA-3
T1163 4375-4383 Positive_regulation denotes mediated
T1164 4384-4388 Protein denotes IL-5
T1165 4393-4396 Protein denotes -13
T1166 4424-4427 Protein denotes CD4
T1167 4472-4483 Binding denotes recruitment
T1168 4487-4489 Protein denotes GR
T1169 4494-4499 Regulation denotes alter
T1170 4515-4521 Protein denotes GATA-3
T1171 4532-4536 Binding denotes bind
T1172 4582-4595 Positive_regulation denotes up-regulation
T1173 4741-4747 Protein denotes GATA-3
T1174 4748-4763 Phosphorylation denotes phosphorylation
T1175 4768-4775 Entity denotes nuclear
T1176 4776-4789 Localization denotes translocation
T1177 4988-4994 Protein denotes GATA-3
T1178 5007-5019 Localization denotes localization
R889 T1072 T1071 themeOf interleukin (IL)-4,expression
R890 T1073 T1071 themeOf IL-5,expression
R891 T1074 T1071 themeOf IL-13,expression
R892 T1078 T1077 themeOf expression,regulate
R893 T1081 T1082 themeOf GATA-3,expressed
R894 T1083 T1084 causeOf GATA-3,activates
R895 T1085 T1084 themeOf promoters,activates
R896 T1085 T1087 partOf promoters,IL-5
R897 T1085 T1088 partOf promoters,IL-13
R898 T1085 T1086 partOf promoters,IL-4
R899 T1096 T1097 themeOf GATA-3,expression
R900 T1097 T1095 themeOf expression,knockdown
R901 T1098 T1099 themeOf GATA-3,translocate
R902 T1100 T1099 locationOf nucleus,translocate
R903 T1102 T1103 locationOf nuclear,expression
R904 T1103 T1101 themeOf expression,Enhanced
R905 T1103 T1105 themeOf expression,following
R906 T1104 T1103 themeOf GATA-3,expression
R907 T1107 T1108 themeOf GATA-3,import
R908 T1107 T1110 themeOf GATA-3,import
R909 T1109 T1108 locationOf nucleus,import
R910 T1115 T1114 themeOf phosphorylating,role
R911 T1116 T1115 themeOf GATA-3,phosphorylating
R912 T1116 T1117 causeOf GATA-3,enhance
R913 T1116 T1118 themeOf GATA-3,interaction
R914 T1118 T1117 themeOf interaction,enhance
R915 T1120 T1119 themeOf glucocorticoid receptors,binding
R916 T1120 T1124 themeOf glucocorticoid receptors,interact
R917 T1120 T1122 themeOf glucocorticoid receptors,translocate
R918 T1121 T1120 equivalentTo GRs,glucocorticoid receptors
R919 T1123 T1122 locationOf nucleus,translocate
R920 T1126 T1127 themeOf GR,interacts
R921 T1126 T1128 themeOf GR,recruitment
R922 T1126 T1125 themeOf GR,activated
R923 T1129 T1128 themeOf histone deacetylase-2,recruitment
R924 T1130 T1131 locationOf Nuclear,localisation
R925 T1131 T1134 themeOf localisation,mediated
R926 T1132 T1134 themeOf retention,mediated
R927 T1133 T1131 themeOf GR,localisation
R928 T1133 T1137 themeOf GR,export
R929 T1133 T1132 themeOf GR,retention
R930 T1133 T1135 themeOf GR,retention
R931 T1136 T1137 locationOf nuclear,export
R932 T1139 T1138 equivalentTo CRM-1,chromosomal region maintenance 1
R933 T1142 T1146 themeOf GR,interaction
R934 T1142 T1143 themeOf GR,translocates
R935 T1143 T1145 themeOf translocates,in response to
R936 T1143 T1141 themeOf translocates,resulting
R937 T1144 T1143 locationOf nucleus,translocates
R938 T1146 T1145 causeOf interaction,in response to
R939 T1147 T1146 themeOf importin 7,interaction
R940 T1148 T1149 themeOf GR,import
R941 T1151 T1154 themeOf GR,import
R942 T1151 T1155 themeOf GR,binding
R943 T1151 T1152 themeOf GR,activation
R944 T1152 T1150 themeOf activation,regulation
R945 T1153 T1154 locationOf nuclear,import
R946 T1154 T1150 themeOf import,regulation
R947 T1155 T1150 themeOf binding,regulation
R948 T1160 T1161 causeOf GR,reduced
R949 T1162 T1163 causeOf GATA-3,mediated
R950 T1163 T1161 themeOf mediated,reduced
R951 T1167 T1169 causeOf recruitment,alter
R952 T1168 T1167 themeOf GR,recruitment
R953 T1170 T1172 themeOf GATA-3,up-regulation
R954 T1170 T1171 themeOf GATA-3,bind
R955 T1173 T1174 themeOf GATA-3,phosphorylation
R956 T1173 T1176 themeOf GATA-3,translocation
R957 T1175 T1176 locationOf nuclear,translocation
R958 T1177 T1178 themeOf GATA-3,localization