| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T43 |
0-28 |
Sentence |
denotes |
What Do These Findings Mean? |
| T44 |
29-236 |
Sentence |
denotes |
These findings, obtained both in the laboratory and in patients, suggest that corticosteroids inhibit the expression of Th2 cytokines and thus reduce allergic inflammation through two interacting mechanisms. |
| T45 |
237-516 |
Sentence |
denotes |
They suggest that corticosteroids prevent the nuclear translocation of GATA-3, a key regulator of Th2 cytokine expression, by competing with GATA-3 for binding to importin-α and by preventing the phosphorylation of GATA-3, a modification that allows GATA-3 to bind to importin-α. |
| T46 |
517-837 |
Sentence |
denotes |
This dual mechanism of corticosteroid action may help to explain why these drugs are so effective in the treatment of allergic diseases, although further experiments are needed to show that the lymphocytes resident at sites of allergic inflammation respond to corticosteroids in the same way as lymphocytes in the blood. |
| T47 |
838-1005 |
Sentence |
denotes |
Finally, these findings suggest that the interaction between phosphorylated GATA-3 and importin-α might be a potential target for new treatments for allergic diseases. |
