PMC:2674207 / 480-919 JSONTXT

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    pmc-enju-pas

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critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}

    bionlp-st-ge-2016-coref

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    bionlp-st-ge-2016-spacy-parsed

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critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}

    GO-BP

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    GO-MF

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    GO-CC

    {"project":"GO-CC","denotations":[{"id":"T778","span":{"begin":119,"end":124},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":" critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}

    sentences

    {"project":"sentences","denotations":[{"id":"T138","span":{"begin":179,"end":294},"obj":"Sentence"},{"id":"T139","span":{"begin":295,"end":432},"obj":"Sentence"},{"id":"T8","span":{"begin":179,"end":294},"obj":"Sentence"},{"id":"T9","span":{"begin":295,"end":432},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":" critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}

    events-check-again

    {"project":"events-check-again","denotations":[{"id":"T880","span":{"begin":18,"end":28},"obj":"Regulation"},{"id":"T881","span":{"begin":18,"end":28},"obj":"Regulation"},{"id":"T882","span":{"begin":18,"end":28},"obj":"Regulation"},{"id":"T883","span":{"begin":33,"end":43},"obj":"Gene_expression"},{"id":"T884","span":{"begin":33,"end":43},"obj":"Gene_expression"},{"id":"T885","span":{"begin":33,"end":43},"obj":"Gene_expression"},{"id":"T886","span":{"begin":61,"end":79},"obj":"Protein"},{"id":"T887","span":{"begin":81,"end":85},"obj":"Protein"},{"id":"T888","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T889","span":{"begin":275,"end":281},"obj":"Protein"},{"id":"T890","span":{"begin":315,"end":321},"obj":"Regulation"},{"id":"T891","span":{"begin":370,"end":376},"obj":"Protein"},{"id":"T892","span":{"begin":377,"end":387},"obj":"Regulation"}],"relations":[{"id":"R684","pred":"themeOf","subj":"T884","obj":"T882"},{"id":"R686","pred":"themeOf","subj":"T885","obj":"T881"},{"id":"R688","pred":"themeOf","subj":"T886","obj":"T884"},{"id":"R689","pred":"themeOf","subj":"T887","obj":"T883"},{"id":"R690","pred":"themeOf","subj":"T888","obj":"T885"},{"id":"R692","pred":"themeOf","subj":"T891","obj":"T892"},{"id":"R694","pred":"themeOf","subj":"T892","obj":"T890"},{"id":"R766","pred":"themeOf","subj":"T883","obj":"T880"}],"text":" critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}

    bionlp-st-ge-2016-reference-tees

    {"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T924","span":{"begin":61,"end":85},"obj":"Protein"},{"id":"T925","span":{"begin":33,"end":43},"obj":"Gene_expression"},{"id":"T926","span":{"begin":18,"end":28},"obj":"Regulation"},{"id":"T927","span":{"begin":275,"end":281},"obj":"Protein"},{"id":"T928","span":{"begin":264,"end":271},"obj":"Regulation"},{"id":"T929","span":{"begin":370,"end":376},"obj":"Protein"},{"id":"T930","span":{"begin":377,"end":387},"obj":"Regulation"},{"id":"T931","span":{"begin":315,"end":321},"obj":"Regulation"}],"relations":[{"id":"R740","pred":"themeOf","subj":"T924","obj":"T925"},{"id":"R742","pred":"themeOf","subj":"T925","obj":"T926"},{"id":"R743","pred":"themeOf","subj":"T927","obj":"T928"},{"id":"R744","pred":"themeOf","subj":"T929","obj":"T930"},{"id":"R745","pred":"themeOf","subj":"T930","obj":"T931"}],"text":" critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}

    bionlp-st-ge-2016-reference

    {"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T96","span":{"begin":18,"end":28},"obj":"Regulation"},{"id":"T97","span":{"begin":18,"end":28},"obj":"Regulation"},{"id":"T98","span":{"begin":18,"end":28},"obj":"Regulation"},{"id":"T99","span":{"begin":33,"end":43},"obj":"Gene_expression"},{"id":"T100","span":{"begin":33,"end":43},"obj":"Gene_expression"},{"id":"T101","span":{"begin":33,"end":43},"obj":"Gene_expression"},{"id":"T102","span":{"begin":61,"end":79},"obj":"Protein"},{"id":"T103","span":{"begin":81,"end":85},"obj":"Protein"},{"id":"T104","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T105","span":{"begin":275,"end":281},"obj":"Protein"},{"id":"T106","span":{"begin":315,"end":321},"obj":"Regulation"},{"id":"T107","span":{"begin":370,"end":376},"obj":"Protein"},{"id":"T108","span":{"begin":377,"end":387},"obj":"Regulation"}],"relations":[{"id":"R71","pred":"themeOf","subj":"T99","obj":"T96"},{"id":"R72","pred":"themeOf","subj":"T100","obj":"T98"},{"id":"R74","pred":"themeOf","subj":"T102","obj":"T100"},{"id":"R73","pred":"themeOf","subj":"T101","obj":"T97"},{"id":"R75","pred":"themeOf","subj":"T103","obj":"T99"},{"id":"R76","pred":"themeOf","subj":"T104","obj":"T101"},{"id":"R77","pred":"themeOf","subj":"T107","obj":"T108"},{"id":"R78","pred":"themeOf","subj":"T108","obj":"T106"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":" critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}

    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T432","span":{"begin":81,"end":85},"obj":"P05113"},{"id":"T433","span":{"begin":91,"end":96},"obj":"P35225"},{"id":"T434","span":{"begin":275,"end":281},"obj":"P23771"},{"id":"T435","span":{"begin":370,"end":376},"obj":"P23771"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":" critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}

    test2

    {"project":"test2","denotations":[{"id":"T53","span":{"begin":10,"end":14},"obj":"Regulation"},{"id":"T54","span":{"begin":18,"end":28},"obj":"Regulation"},{"id":"T55","span":{"begin":33,"end":43},"obj":"Gene_expression"},{"id":"T56","span":{"begin":61,"end":79},"obj":"Protein"},{"id":"T57","span":{"begin":81,"end":85},"obj":"Protein"},{"id":"T58","span":{"begin":91,"end":96},"obj":"Protein"},{"id":"T59","span":{"begin":264,"end":271},"obj":"Regulation"},{"id":"T60","span":{"begin":275,"end":281},"obj":"Protein"},{"id":"T61","span":{"begin":370,"end":376},"obj":"Protein"},{"id":"T62","span":{"begin":377,"end":387},"obj":"Regulation"}],"relations":[{"id":"R44","pred":"themeOf","subj":"T55","obj":"T54"},{"id":"R45","pred":"themeOf","subj":"T56","obj":"T55"},{"id":"R46","pred":"themeOf","subj":"T57","obj":"T55"},{"id":"R47","pred":"themeOf","subj":"T58","obj":"T55"},{"id":"R48","pred":"themeOf","subj":"T60","obj":"T59"},{"id":"R49","pred":"themeOf","subj":"T61","obj":"T62"}],"text":" critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.\n\nMetho"}