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{"project":"GO-MF","denotations":[{"id":"T770","span":{"begin":99,"end":104},"obj":"http://purl.obolibrary.org/obo/GO_0005136"},{"id":"T771","span":{"begin":106,"end":110},"obj":"http://purl.obolibrary.org/obo/GO_0005137"},{"id":"T772","span":{"begin":116,"end":121},"obj":"http://purl.obolibrary.org/obo/GO_0005144"}],"text":"Background\nGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo."}

{"project":"GO-CC","denotations":[{"id":"T778","span":{"begin":144,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Background\nGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo."}

{"project":"sentences","denotations":[{"id":"T136","span":{"begin":0,"end":10},"obj":"Sentence"},{"id":"T137","span":{"begin":11,"end":203},"obj":"Sentence"},{"id":"T138","span":{"begin":204,"end":319},"obj":"Sentence"},{"id":"T139","span":{"begin":320,"end":457},"obj":"Sentence"},{"id":"T6","span":{"begin":0,"end":10},"obj":"Sentence"},{"id":"T7","span":{"begin":11,"end":203},"obj":"Sentence"},{"id":"T8","span":{"begin":204,"end":319},"obj":"Sentence"},{"id":"T9","span":{"begin":320,"end":457},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Background\nGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo."}

{"project":"events-check-again","denotations":[{"id":"T879","span":{"begin":11,"end":17},"obj":"Protein"},{"id":"T880","span":{"begin":43,"end":53},"obj":"Regulation"},{"id":"T881","span":{"begin":43,"end":53},"obj":"Regulation"},{"id":"T882","span":{"begin":43,"end":53},"obj":"Regulation"},{"id":"T883","span":{"begin":58,"end":68},"obj":"Gene_expression"},{"id":"T884","span":{"begin":58,"end":68},"obj":"Gene_expression"},{"id":"T885","span":{"begin":58,"end":68},"obj":"Gene_expression"},{"id":"T886","span":{"begin":86,"end":104},"obj":"Protein"},{"id":"T887","span":{"begin":106,"end":110},"obj":"Protein"},{"id":"T888","span":{"begin":116,"end":121},"obj":"Protein"},{"id":"T889","span":{"begin":300,"end":306},"obj":"Protein"},{"id":"T890","span":{"begin":340,"end":346},"obj":"Regulation"},{"id":"T891","span":{"begin":395,"end":401},"obj":"Protein"},{"id":"T892","span":{"begin":402,"end":412},"obj":"Regulation"}],"relations":[{"id":"R684","pred":"themeOf","subj":"T884","obj":"T882"},{"id":"R686","pred":"themeOf","subj":"T885","obj":"T881"},{"id":"R688","pred":"themeOf","subj":"T886","obj":"T884"},{"id":"R689","pred":"themeOf","subj":"T887","obj":"T883"},{"id":"R690","pred":"themeOf","subj":"T888","obj":"T885"},{"id":"R692","pred":"themeOf","subj":"T891","obj":"T892"},{"id":"R694","pred":"themeOf","subj":"T892","obj":"T890"},{"id":"R760","pred":"causeOf","subj":"T879","obj":"T882"},{"id":"R762","pred":"causeOf","subj":"T879","obj":"T880"},{"id":"R763","pred":"causeOf","subj":"T879","obj":"T881"},{"id":"R766","pred":"themeOf","subj":"T883","obj":"T880"}],"text":"Background\nGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T923","span":{"begin":11,"end":17},"obj":"Protein"},{"id":"T924","span":{"begin":86,"end":110},"obj":"Protein"},{"id":"T925","span":{"begin":58,"end":68},"obj":"Gene_expression"},{"id":"T926","span":{"begin":43,"end":53},"obj":"Regulation"},{"id":"T927","span":{"begin":300,"end":306},"obj":"Protein"},{"id":"T928","span":{"begin":289,"end":296},"obj":"Regulation"},{"id":"T929","span":{"begin":395,"end":401},"obj":"Protein"},{"id":"T930","span":{"begin":402,"end":412},"obj":"Regulation"},{"id":"T931","span":{"begin":340,"end":346},"obj":"Regulation"}],"relations":[{"id":"R739","pred":"causeOf","subj":"T923","obj":"T926"},{"id":"R740","pred":"themeOf","subj":"T924","obj":"T925"},{"id":"R742","pred":"themeOf","subj":"T925","obj":"T926"},{"id":"R743","pred":"themeOf","subj":"T927","obj":"T928"},{"id":"R744","pred":"themeOf","subj":"T929","obj":"T930"},{"id":"R745","pred":"themeOf","subj":"T930","obj":"T931"}],"text":"Background\nGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T96","span":{"begin":43,"end":53},"obj":"Regulation"},{"id":"T97","span":{"begin":43,"end":53},"obj":"Regulation"},{"id":"T98","span":{"begin":43,"end":53},"obj":"Regulation"},{"id":"T99","span":{"begin":58,"end":68},"obj":"Gene_expression"},{"id":"T100","span":{"begin":58,"end":68},"obj":"Gene_expression"},{"id":"T101","span":{"begin":58,"end":68},"obj":"Gene_expression"},{"id":"T102","span":{"begin":86,"end":104},"obj":"Protein"},{"id":"T103","span":{"begin":106,"end":110},"obj":"Protein"},{"id":"T104","span":{"begin":116,"end":121},"obj":"Protein"},{"id":"T105","span":{"begin":300,"end":306},"obj":"Protein"},{"id":"T106","span":{"begin":340,"end":346},"obj":"Regulation"},{"id":"T107","span":{"begin":395,"end":401},"obj":"Protein"},{"id":"T108","span":{"begin":402,"end":412},"obj":"Regulation"},{"id":"T95","span":{"begin":11,"end":17},"obj":"Protein"}],"relations":[{"id":"R71","pred":"themeOf","subj":"T99","obj":"T96"},{"id":"R72","pred":"themeOf","subj":"T100","obj":"T98"},{"id":"R74","pred":"themeOf","subj":"T102","obj":"T100"},{"id":"R774","pred":"causeOf","subj":"T95","obj":"T98"},{"id":"R775","pred":"causeOf","subj":"T95","obj":"T96"},{"id":"R73","pred":"themeOf","subj":"T101","obj":"T97"},{"id":"R75","pred":"themeOf","subj":"T103","obj":"T99"},{"id":"R76","pred":"themeOf","subj":"T104","obj":"T101"},{"id":"R77","pred":"themeOf","subj":"T107","obj":"T108"},{"id":"R78","pred":"themeOf","subj":"T108","obj":"T106"},{"id":"R776","pred":"causeOf","subj":"T95","obj":"T97"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Background\nGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T431","span":{"begin":11,"end":17},"obj":"P23771"},{"id":"T432","span":{"begin":106,"end":110},"obj":"P05113"},{"id":"T433","span":{"begin":116,"end":121},"obj":"P35225"},{"id":"T434","span":{"begin":300,"end":306},"obj":"P23771"},{"id":"T435","span":{"begin":395,"end":401},"obj":"P23771"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Background\nGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo."}

{"project":"test2","denotations":[{"id":"T52","span":{"begin":11,"end":17},"obj":"Protein"},{"id":"T53","span":{"begin":35,"end":39},"obj":"Regulation"},{"id":"T54","span":{"begin":43,"end":53},"obj":"Regulation"},{"id":"T55","span":{"begin":58,"end":68},"obj":"Gene_expression"},{"id":"T56","span":{"begin":86,"end":104},"obj":"Protein"},{"id":"T57","span":{"begin":106,"end":110},"obj":"Protein"},{"id":"T58","span":{"begin":116,"end":121},"obj":"Protein"},{"id":"T59","span":{"begin":289,"end":296},"obj":"Regulation"},{"id":"T60","span":{"begin":300,"end":306},"obj":"Protein"},{"id":"T61","span":{"begin":395,"end":401},"obj":"Protein"},{"id":"T62","span":{"begin":402,"end":412},"obj":"Regulation"}],"relations":[{"id":"R42","pred":"causeOf","subj":"T52","obj":"T54"},{"id":"R43","pred":"causeOf","subj":"T52","obj":"T53"},{"id":"R44","pred":"themeOf","subj":"T55","obj":"T54"},{"id":"R45","pred":"themeOf","subj":"T56","obj":"T55"},{"id":"R46","pred":"themeOf","subj":"T57","obj":"T55"},{"id":"R47","pred":"themeOf","subj":"T58","obj":"T55"},{"id":"R48","pred":"themeOf","subj":"T60","obj":"T59"},{"id":"R49","pred":"themeOf","subj":"T61","obj":"T62"}],"text":"Background\nGATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases. Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown. We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo."}