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PMC:2674207 / 39909-45398 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
19436703-17277157-86274499 907-909 17277157 denotes 12
19436703-17277157-86274500 1139-1141 17277157 denotes 12
19436703-9891038-86274501 1241-1243 9891038 denotes 22
19436703-12391149-86274502 2756-2758 12391149 denotes 38
19436703-17099067-86274503 2761-2763 17099067 denotes 39
19436703-11140432-86274504 3827-3829 11140432 denotes 37
19436703-12001789-86274505 4534-4536 12001789 denotes 40
19436703-10887335-86274506 4539-4541 10887335 denotes 42
19436703-16266385-86274507 5322-5324 16266385 denotes 43
T69957 907-909 17277157 denotes 12
T58723 1139-1141 17277157 denotes 12
T89702 1241-1243 9891038 denotes 22
T56173 2756-2758 12391149 denotes 38
T354 2761-2763 17099067 denotes 39
T43358 3827-3829 11140432 denotes 37
T80830 4534-4536 12001789 denotes 40
T19947 4539-4541 10887335 denotes 42
T80216 5322-5324 16266385 denotes 43

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T13351 11-15 RB denotes Here
T13352 16-18 PRP denotes we
T13353 19-23 VB denotes have
T13354 24-36 VB denotes demonstrated
T13355 36-37 -COMMA- denotes ,
T13356 38-40 TO denotes to
T13357 41-44 PRP-DOLLAR- denotes our
T13358 45-54 NN denotes knowledge
T13359 55-58 IN denotes for
T13360 59-62 DT denotes the
T13361 63-68 JJ denotes first
T13362 69-73 NN denotes time
T13363 73-74 -COMMA- denotes ,
T13364 75-79 IN denotes that
T13365 80-95 NN denotes corticosteroids
T13366 96-99 MD denotes may
T13367 100-107 VB denotes inhibit
T13368 108-114 NN denotes GATA-3
T13369 115-123 NN denotes function
T13370 124-127 CC denotes and
T13371 128-137 RB denotes therefore
T13372 138-141 DT denotes the
T13373 142-155 NN denotes transcription
T13374 156-158 IN denotes of
T13375 159-162 NN denotes Th2
T13376 163-168 NN denotes genes
T13377 169-172 IN denotes via
T13378 173-176 CD denotes two
T13379 177-185 JJ denotes distinct
T13380 186-189 CC denotes but
T13381 190-201 VB denotes interacting
T13382 202-211 JJ denotes molecular
T13383 212-222 NN denotes mechanisms
T13384 224-231 RB denotes Firstly
T13385 231-232 -COMMA- denotes ,
T13386 233-257 JJ denotes corticosteroid-activated
T13387 258-260 NN denotes GR
T13388 261-268 VB denotes appears
T13389 269-271 TO denotes to
T13390 272-279 VB denotes compete
T13391 280-284 IN denotes with
T13392 285-294 VB denotes activated
T13393 295-301 NN denotes GATA-3
T13394 302-305 IN denotes for
T13395 306-313 JJ denotes nuclear
T13396 314-320 NN denotes import
T13397 321-324 IN denotes via
T13398 325-335 NN denotes importin-α
T13399 335-336 -COMMA- denotes ,
T13400 337-342 WDT denotes which
T13401 343-345 VB denotes is
T13402 346-354 VB denotes required
T13403 355-358 IN denotes for
T13404 359-362 DT denotes the
T13405 363-370 JJ denotes nuclear
T13406 371-380 NN denotes transport
T13407 381-383 IN denotes of
T13408 384-388 CC denotes both
T13409 389-395 NN denotes GATA-3
T13410 396-399 CC denotes and
T13411 400-402 NN denotes GR
T13412 404-412 RB denotes Secondly
T13413 412-413 -COMMA- denotes ,
T13414 414-429 NN denotes corticosteroids
T13415 430-432 IN denotes at
T13416 433-439 JJ denotes higher
T13417 440-454 NN denotes concentrations
T13418 455-463 VB denotes increase
T13419 464-467 DT denotes the
T13420 468-478 NN denotes expression
T13421 479-481 IN denotes of
T13422 482-487 NN denotes MKP-1
T13423 487-488 -COMMA- denotes ,
T13424 489-490 DT denotes a
T13425 491-497 JJ denotes potent
T13426 498-507 NN denotes inhibitor
T13427 508-510 IN denotes of
T13428 511-514 NN denotes p38
T13429 515-519 NN denotes MAPK
T13430 520-528 NN denotes activity
T13431 529-532 CC denotes and
T13432 533-540 RB denotes thereby
T13433 541-548 VB denotes prevent
T13434 549-550 NN denotes T
T13435 551-555 NN denotes cell
T13436 556-576 NN denotes receptor/co-receptor
T13437 577-587 NN denotes activation
T13438 588-590 IN denotes of
T13439 591-594 NN denotes p38
T13440 595-599 NN denotes MAPK
T13441 600-602 TO denotes to
T13442 603-610 VB denotes prevent
T13443 611-614 DT denotes the
T13444 615-630 NN denotes phosphorylation
T13445 631-633 IN denotes of
T13446 634-640 NN denotes GATA-3
T13447 641-645 WDT denotes that
T13448 646-648 VB denotes is
T13449 649-658 JJ denotes necessary
T13450 659-662 IN denotes for
T13451 663-674 NN denotes interaction
T13452 675-679 IN denotes with
T13453 680-690 JJ denotes importin-α
T13454 691-694 CC denotes and
T13455 695-705 JJ denotes subsequent
T13456 706-713 JJ denotes nuclear
T13457 714-720 NN denotes import
T13458 722-724 PRP denotes We
T13459 725-729 VB denotes have
T13460 730-740 RB denotes previously
T13461 741-746 VB denotes shown
T13462 747-751 IN denotes that
T13463 752-765 NN denotes translocation
T13464 766-768 IN denotes of
T13465 769-775 NN denotes GATA-3
T13466 776-780 IN denotes from
T13467 781-784 DT denotes the
T13468 785-794 NN denotes cytoplasm
T13469 795-797 TO denotes to
T13470 798-801 DT denotes the
T13471 802-809 NN denotes nucleus
T13472 810-818 VB denotes involves
T13473 819-822 DT denotes the
T13474 823-830 JJ denotes nuclear
T13475 831-842 NN denotes transporter
T13476 843-850 NN denotes protein
T13477 851-861 NN denotes importin-α
T13478 861-862 -COMMA- denotes ,
T13479 863-868 WDT denotes which
T13480 869-878 VB denotes interacts
T13481 879-883 IN denotes with
T13482 884-898 VB denotes phosphorylated
T13483 899-905 NN denotes GATA-3
T13484 906-907 -LRB- denotes [
T13485 907-909 CD denotes 12
T13486 909-910 -RRB- denotes ]
T13487 912-914 PRP denotes We
T13488 915-919 VB denotes have
T13489 920-924 RB denotes also
T13490 925-935 RB denotes previously
T13491 936-944 VB denotes reported
T13492 945-949 IN denotes that
T13493 950-956 NN denotes GATA-3
T13494 957-966 NN denotes knockdown
T13495 967-972 VB denotes using
T13496 973-978 NN denotes siRNA
T13497 979-986 VB denotes results
T13498 987-989 IN denotes in
T13499 990-1001 NN denotes suppression
T13500 1002-1004 IN denotes of
T13501 1005-1029 JJ denotes anti-CD3/CD28–stimulated
T13502 1030-1039 NN denotes IL-4/IL-5
T13503 1040-1044 NN denotes mRNA
T13504 1045-1054 NN denotes induction
T13505 1054-1055 -COMMA- denotes ,
T13506 1056-1060 RB denotes thus
T13507 1061-1072 VB denotes implicating
T13508 1073-1075 DT denotes an
T13509 1076-1085 JJ denotes essential
T13510 1086-1090 NN denotes role
T13511 1091-1094 IN denotes for
T13512 1095-1101 NN denotes GATA-3
T13513 1102-1104 IN denotes in
T13514 1105-1108 DT denotes the
T13515 1109-1122 NN denotes transcription
T13516 1123-1125 IN denotes of
T13517 1126-1131 DT denotes these
T13518 1132-1137 NN denotes genes
T13519 1138-1139 -LRB- denotes [
T13520 1139-1141 CD denotes 12
T13521 1141-1142 -RRB- denotes ]
T13522 1144-1146 PRP denotes We
T13523 1147-1150 RB denotes now
T13524 1151-1158 VB denotes confirm
T13525 1158-1159 -COMMA- denotes ,
T13526 1160-1162 IN denotes in
T13527 1163-1168 JJ denotes human
T13528 1169-1170 NN denotes T
T13529 1171-1176 NN denotes cells
T13530 1176-1177 -COMMA- denotes ,
T13531 1178-1182 IN denotes that
T13532 1183-1185 NN denotes GR
T13533 1186-1190 RB denotes also
T13534 1191-1195 VB denotes uses
T13535 1196-1199 DT denotes the
T13536 1200-1204 JJ denotes same
T13537 1205-1212 JJ denotes nuclear
T13538 1213-1219 NN denotes import
T13539 1220-1229 NN denotes mechanism
T13540 1230-1232 IN denotes as
T13541 1233-1239 NN denotes GATA-3
T13542 1240-1241 -LRB- denotes [
T13543 1241-1243 CD denotes 22
T13544 1243-1244 -RRB- denotes ]
T13545 1246-1248 PRP denotes We
T13546 1249-1258 RB denotes therefore
T13547 1259-1266 VB denotes propose
T13548 1267-1271 IN denotes that
T13549 1272-1277 EX denotes there
T13550 1278-1280 VB denotes is
T13551 1281-1292 NN denotes competition
T13552 1293-1300 IN denotes between
T13553 1301-1317 JJ denotes ligand-activated
T13554 1318-1320 NN denotes GR
T13555 1321-1324 CC denotes and
T13556 1325-1339 NN denotes phospho-GATA-3
T13557 1340-1343 IN denotes for
T13558 1344-1351 JJ denotes nuclear
T13559 1352-1358 NN denotes import
T13560 1360-1371 RB denotes Furthermore
T13561 1371-1372 -COMMA- denotes ,
T13562 1373-1375 PRP denotes we
T13563 1376-1380 VB denotes have
T13564 1381-1386 VB denotes shown
T13565 1387-1391 IN denotes that
T13566 1392-1397 EX denotes there
T13567 1398-1400 VB denotes is
T13568 1401-1413 JJ denotes preferential
T13569 1414-1421 NN denotes binding
T13570 1422-1424 IN denotes of
T13571 1425-1435 NN denotes importin-α
T13572 1436-1438 TO denotes to
T13573 1439-1448 VB denotes activated
T13574 1449-1451 NN denotes GR
T13575 1452-1456 IN denotes over
T13576 1457-1471 NN denotes phospho-GATA-3
T13577 1471-1472 -COMMA- denotes ,
T13578 1473-1475 IN denotes so
T13579 1476-1480 IN denotes that
T13580 1481-1496 NN denotes corticosteroids
T13581 1497-1502 MD denotes would
T13582 1503-1517 RB denotes preferentially
T13583 1518-1524 VB denotes reduce
T13584 1525-1531 NN denotes GATA-3
T13585 1532-1537 NN denotes entry
T13586 1538-1541 CC denotes and
T13587 1542-1546 RB denotes thus
T13588 1547-1554 RB denotes rapidly
T13589 1555-1561 VB denotes switch
T13590 1562-1565 RP denotes off
T13591 1566-1569 NN denotes Th2
T13592 1570-1574 NN denotes gene
T13593 1575-1588 NN denotes transcription
T13594 1589-1596 IN denotes without
T13595 1597-1600 DT denotes any
T13596 1601-1605 NN denotes need
T13597 1606-1609 IN denotes for
T13598 1610-1613 DT denotes any
T13599 1614-1626 JJ denotes intermediate
T13600 1627-1632 NN denotes steps
T13601 1634-1645 RB denotes Furthermore
T13602 1645-1646 -COMMA- denotes ,
T13603 1647-1652 EX denotes there
T13604 1653-1656 VB denotes was
T13605 1657-1661 DT denotes some
T13606 1662-1668 NN denotes degree
T13607 1669-1671 IN denotes of
T13608 1672-1683 NN denotes specificity
T13609 1684-1687 IN denotes for
T13610 1688-1694 NN denotes GATA-3
T13611 1694-1695 -COMMA- denotes ,
T13612 1696-1698 IN denotes as
T13613 1699-1706 JJ denotes nuclear
T13614 1707-1720 NN denotes translocation
T13615 1721-1723 IN denotes of
T13616 1724-1727 DT denotes the
T13617 1728-1731 NN denotes p65
T13618 1732-1739 NN denotes subunit
T13619 1740-1742 IN denotes of
T13620 1743-1748 NN denotes NF-κB
T13621 1749-1752 VB denotes was
T13622 1753-1756 RB denotes not
T13623 1757-1765 VB denotes affected
T13624 1766-1768 IN denotes by
T13625 1769-1783 NN denotes corticosteroid
T13626 1784-1792 NN denotes exposure
T13627 1794-1796 PRP denotes We
T13628 1797-1803 VB denotes tested
T13629 1804-1808 DT denotes some
T13630 1809-1820 JJ denotes alternative
T13631 1821-1833 NN denotes explanations
T13632 1834-1837 IN denotes for
T13633 1838-1842 DT denotes this
T13634 1843-1849 NN denotes effect
T13635 1850-1852 IN denotes of
T13636 1853-1855 NN denotes FP
T13637 1856-1858 IN denotes on
T13638 1859-1865 NN denotes GATA-3
T13639 1866-1873 JJ denotes nuclear
T13640 1874-1883 NN denotes exclusion
T13641 1884-1887 CC denotes and
T13642 1888-1894 VB denotes failed
T13643 1895-1897 TO denotes to
T13644 1898-1902 VB denotes show
T13645 1903-1907 IN denotes that
T13646 1908-1910 NN denotes FP
T13647 1911-1917 CC denotes either
T13648 1918-1926 VB denotes enhances
T13649 1927-1933 NN denotes GATA-3
T13650 1934-1941 JJ denotes nuclear
T13651 1942-1948 NN denotes export
T13652 1949-1957 RB denotes directly
T13653 1958-1960 CC denotes or
T13654 1961-1968 VB denotes induces
T13655 1969-1975 NN denotes GATA-3
T13656 1976-1987 NN denotes degradation
T13657 1989-1992 DT denotes The
T13658 1993-2001 NN denotes evidence
T13659 2002-2006 IN denotes from
T13660 2007-2010 DT denotes the
T13661 2011-2013 FW denotes in
T13662 2014-2019 FW denotes vitro
T13663 2020-2031 NN denotes competition
T13664 2032-2038 NN denotes assays
T13665 2039-2043 VB denotes does
T13666 2043-2044 -COMMA- denotes ,
T13667 2045-2052 RB denotes however
T13668 2052-2053 -COMMA- denotes ,
T13669 2054-2061 VB denotes suggest
T13670 2062-2066 IN denotes that
T13671 2067-2075 VB denotes purified
T13672 2076-2085 VB denotes activated
T13673 2086-2088 NN denotes GR
T13674 2089-2092 MD denotes can
T13675 2093-2100 RB denotes clearly
T13676 2101-2110 VB denotes attenuate
T13677 2111-2119 VB denotes purified
T13678 2120-2145 NN denotes phospho-GATA-3–importin-α
T13679 2146-2157 NN denotes association
T13680 2158-2161 CC denotes and
T13681 2162-2166 IN denotes that
T13682 2167-2170 DT denotes the
T13683 2171-2179 NN denotes converse
T13684 2180-2184 VB denotes does
T13685 2185-2188 RB denotes not
T13686 2189-2194 VB denotes occur
T13687 2196-2207 RB denotes Furthermore
T13688 2207-2208 -COMMA- denotes ,
T13689 2209-2211 PRP denotes we
T13690 2212-2216 VB denotes have
T13691 2217-2222 VB denotes shown
T13692 2223-2227 IN denotes that
T13693 2228-2232 RB denotes only
T13694 2233-2247 NN denotes phospho-GATA-3
T13695 2248-2251 MD denotes can
T13696 2252-2261 VB denotes associate
T13697 2262-2266 IN denotes with
T13698 2267-2277 NN denotes importin-α
T13699 2279-2283 DT denotes This
T13700 2284-2293 NN denotes mechanism
T13701 2294-2296 VB denotes is
T13702 2297-2306 JJ denotes sensitive
T13703 2307-2309 TO denotes to
T13704 2310-2314 RB denotes very
T13705 2315-2318 JJ denotes low
T13706 2319-2333 NN denotes concentrations
T13707 2334-2336 IN denotes of
T13708 2337-2351 NN denotes corticosteroid
T13709 2352-2355 CC denotes and
T13710 2356-2361 MD denotes would
T13711 2362-2364 VB denotes be
T13712 2365-2370 JJ denotes rapid
T13713 2371-2373 IN denotes in
T13714 2374-2379 NN denotes onset
T13715 2380-2382 IN denotes as
T13716 2383-2385 DT denotes no
T13717 2386-2393 NN denotes changes
T13718 2394-2396 IN denotes in
T13719 2397-2404 NN denotes protein
T13720 2405-2414 NN denotes synthesis
T13721 2415-2418 VB denotes are
T13722 2419-2427 VB denotes required
T13723 2429-2433 DT denotes This
T13724 2434-2439 JJ denotes acute
T13725 2440-2449 NN denotes mechanism
T13726 2450-2453 MD denotes may
T13727 2454-2458 RB denotes also
T13728 2459-2469 VB denotes contribute
T13729 2470-2472 TO denotes to
T13730 2473-2476 DT denotes the
T13731 2477-2486 NN denotes reduction
T13732 2487-2489 IN denotes in
T13733 2490-2496 NN denotes GATA-3
T13734 2497-2504 JJ denotes nuclear
T13735 2505-2511 NN denotes import
T13736 2512-2515 CC denotes and
T13737 2516-2519 MD denotes may
T13738 2520-2524 VB denotes play
T13739 2525-2526 DT denotes a
T13740 2527-2532 JJ denotes major
T13741 2533-2537 NN denotes role
T13742 2538-2540 IN denotes at
T13743 2541-2544 JJ denotes low
T13744 2545-2559 NN denotes corticosteroid
T13745 2560-2574 NN denotes concentrations
T13746 2575-2581 CC denotes and/or
T13747 2582-2584 IN denotes at
T13748 2585-2590 JJ denotes early
T13749 2591-2595 NN denotes time
T13750 2596-2602 NN denotes points
T13751 2603-2608 RB denotes prior
T13752 2609-2611 TO denotes to
T13753 2612-2617 NN denotes MKP-1
T13754 2618-2627 NN denotes induction
T13755 2629-2644 NN denotes Corticosteroids
T13756 2645-2648 MD denotes can
T13757 2649-2657 VB denotes modulate
T13758 2658-2661 NN denotes p38
T13759 2662-2666 NN denotes MAPK
T13760 2667-2675 NN denotes activity
T13761 2676-2683 IN denotes through
T13762 2684-2687 DT denotes the
T13763 2688-2697 NN denotes induction
T13764 2698-2700 IN denotes of
T13765 2701-2706 NN denotes MKP-1
T13766 2706-2707 -COMMA- denotes ,
T13767 2708-2709 DT denotes a
T13768 2710-2716 JJ denotes potent
T13769 2717-2727 JJ denotes endogenous
T13770 2728-2737 NN denotes inhibitor
T13771 2738-2740 IN denotes of
T13772 2741-2745 NN denotes MAPK
T13773 2746-2754 NN denotes function
T13774 2755-2756 -LRB- denotes [
T13775 2756-2758 CD denotes 38
T13776 2758-2759 -RRB- denotes ]
T13777 2759-2760 -COMMA- denotes ,
T13778 2760-2761 -LRB- denotes [
T13779 2761-2763 CD denotes 39
T13780 2763-2764 -RRB- denotes ]
T13781 2766-2768 PRP denotes We
T13782 2769-2775 VB denotes report
T13783 2776-2780 RB denotes here
T13784 2781-2782 DT denotes a
T13785 2783-2788 JJ denotes rapid
T13786 2789-2798 NN denotes induction
T13787 2799-2801 IN denotes of
T13788 2802-2807 NN denotes MKP-1
T13789 2808-2812 NN denotes mRNA
T13790 2813-2822 VB denotes following
T13791 2823-2834 NN denotes stimulation
T13792 2835-2837 IN denotes of
T13793 2838-2843 NN denotes cells
T13794 2844-2848 IN denotes with
T13795 2849-2859 RB denotes relatively
T13796 2860-2864 JJ denotes high
T13797 2865-2879 NN denotes concentrations
T13798 2880-2882 IN denotes of
T13799 2883-2885 NN denotes FP
T13800 2887-2889 PRP denotes We
T13801 2890-2901 VB denotes hypothesize
T13802 2902-2906 IN denotes that
T13803 2907-2911 DT denotes this
T13804 2912-2917 JJ denotes rapid
T13805 2918-2927 NN denotes induction
T13806 2928-2930 IN denotes of
T13807 2931-2936 NN denotes MKP-1
T13808 2937-2940 MD denotes can
T13809 2941-2947 VB denotes reduce
T13810 2948-2954 NN denotes GATA-3
T13811 2955-2962 JJ denotes nuclear
T13812 2963-2969 NN denotes import
T13813 2970-2972 IN denotes by
T13814 2973-2984 VB denotes attenuating
T13815 2985-2988 NN denotes p38
T13816 2989-2993 NN denotes MAPK
T13817 2994-3002 NN denotes activity
T13818 3003-3006 CC denotes and
T13819 3007-3017 JJ denotes subsequent
T13820 3018-3024 NN denotes GATA-3
T13821 3025-3040 NN denotes phosphorylation
T13822 3040-3041 -COMMA- denotes ,
T13823 3042-3046 RB denotes thus
T13824 3047-3057 VB denotes preventing
T13825 3058-3065 JJ denotes nuclear
T13826 3066-3079 NN denotes translocation
T13827 3081-3084 DT denotes The
T13828 3085-3093 NN denotes location
T13829 3094-3096 IN denotes of
T13830 3097-3100 DT denotes the
T13831 3101-3107 NN denotes serine
T13832 3108-3115 NN denotes residue
T13833 3115-3116 -LRB- denotes (
T13834 3116-3117 NN denotes s
T13835 3117-3118 -RRB- denotes )
T13836 3119-3121 IN denotes of
T13837 3122-3128 NN denotes GATA-3
T13838 3129-3133 WDT denotes that
T13839 3134-3137 VB denotes are
T13840 3138-3152 VB denotes phosphorylated
T13841 3153-3155 IN denotes by
T13842 3156-3159 NN denotes p38
T13843 3160-3164 NN denotes MAPK
T13844 3165-3168 VB denotes are
T13845 3169-3178 RB denotes currently
T13846 3179-3186 JJ denotes unknown
T13847 3186-3187 -COMMA- denotes ,
T13848 3188-3191 CC denotes but
T13849 3192-3193 DT denotes a
T13850 3194-3208 NN denotes bioinformatics
T13851 3209-3215 NN denotes search
T13852 3216-3217 -LRB- denotes (
T13853 3217-3222 NNP denotes Motif
T13854 3223-3230 NNP denotes Scanner
T13855 3230-3231 -COMMA- denotes ,
T13856 3232-3236 NN denotes http
T13857 3236-3237 -COLON- denotes :
T13858 3237-3275 LS denotes //scansite.mit.edu/motifscan_seq.phtml
T13859 3275-3276 -RRB- denotes )
T13860 3277-3286 VB denotes indicates
T13861 3287-3289 IN denotes at
T13862 3290-3295 JJ denotes least
T13863 3296-3301 CD denotes three
T13864 3302-3311 JJ denotes potential
T13865 3312-3315 NN denotes p38
T13866 3316-3330 JJ denotes MAPK-sensitive
T13867 3331-3337 NN denotes serine
T13868 3338-3346 NN denotes residues
T13869 3348-3350 IN denotes As
T13870 3351-3360 VB denotes predicted
T13871 3361-3365 IN denotes from
T13872 3366-3371 DT denotes these
T13873 3372-3374 FW denotes in
T13874 3375-3380 FW denotes vitro
T13875 3381-3385 NN denotes data
T13876 3385-3386 -COMMA- denotes ,
T13877 3387-3397 NN denotes impairment
T13878 3398-3400 IN denotes of
T13879 3401-3407 NN denotes GATA-3
T13880 3408-3415 JJ denotes nuclear
T13881 3416-3422 NN denotes import
T13882 3423-3425 IN denotes by
T13883 3426-3428 NN denotes FP
T13884 3429-3432 MD denotes may
T13885 3432-3433 -COMMA- denotes ,
T13886 3434-3436 IN denotes at
T13887 3437-3442 JJ denotes least
T13888 3443-3445 IN denotes in
T13889 3446-3450 NN denotes part
T13890 3450-3451 -COMMA- denotes ,
T13891 3452-3460 VB denotes underlie
T13892 3461-3464 DT denotes the
T13893 3465-3473 NN denotes efficacy
T13894 3474-3476 IN denotes of
T13895 3477-3492 NN denotes corticosteroids
T13896 3493-3495 IN denotes in
T13897 3496-3507 VB denotes suppressing
T13898 3508-3516 JJ denotes allergic
T13899 3517-3529 NN denotes inflammation
T13900 3531-3539 IN denotes Although
T13901 3540-3542 PRP denotes we
T13902 3543-3546 VB denotes did
T13903 3547-3550 RB denotes not
T13904 3551-3557 VB denotes assess
T13905 3558-3561 DT denotes the
T13906 3562-3567 JJ denotes acute
T13907 3568-3578 JJ denotes inhibitory
T13908 3579-3585 NN denotes effect
T13909 3586-3588 IN denotes of
T13910 3589-3591 NN denotes FP
T13911 3592-3594 IN denotes on
T13912 3595-3598 DT denotes the
T13913 3599-3609 NN denotes expression
T13914 3610-3612 IN denotes of
T13915 3613-3617 NN denotes IL-4
T13916 3618-3622 NN denotes mRNA
T13917 3623-3625 FW denotes in
T13918 3626-3630 FW denotes vivo
T13919 3630-3631 -COMMA- denotes ,
T13920 3632-3633 DT denotes a
T13921 3634-3640 JJ denotes single
T13922 3641-3651 NN denotes inhalation
T13923 3652-3654 IN denotes of
T13924 3655-3657 NN denotes FP
T13925 3658-3659 -LRB- denotes (
T13926 3659-3662 CD denotes 500
T13927 3663-3665 NN denotes µg
T13928 3665-3666 -RRB- denotes )
T13929 3667-3670 MD denotes may
T13930 3671-3675 VB denotes have
T13931 3676-3686 JJ denotes comparable
T13932 3687-3694 NN denotes effects
T13933 3694-3695 -COMMA- denotes ,
T13934 3696-3698 IN denotes as
T13935 3699-3701 PRP denotes it
T13936 3702-3710 VB denotes provides
T13937 3711-3717 NN denotes plasma
T13938 3718-3724 NN denotes levels
T13939 3725-3731 IN denotes within
T13940 3732-3733 DT denotes a
T13941 3734-3742 JJ denotes relevant
T13942 3743-3748 NN denotes range
T13943 3749-3751 IN denotes of
T13944 3752-3766 NN denotes concentrations
T13945 3767-3771 VB denotes used
T13946 3772-3774 TO denotes to
T13947 3775-3783 VB denotes suppress
T13948 3784-3788 NN denotes IL-4
T13949 3789-3802 NN denotes transcription
T13950 3803-3805 IN denotes in
T13951 3806-3809 PRP-DOLLAR- denotes our
T13952 3810-3812 FW denotes in
T13953 3813-3818 FW denotes vitro
T13954 3819-3825 NN denotes system
T13955 3826-3827 -LRB- denotes [
T13956 3827-3829 CD denotes 37
T13957 3829-3830 -RRB- denotes ]
T13958 3832-3833 DT denotes A
T13959 3834-3839 JJ denotes lower
T13960 3840-3844 NN denotes dose
T13961 3845-3847 IN denotes of
T13962 3848-3855 VB denotes inhaled
T13963 3856-3858 NN denotes FP
T13964 3859-3860 -LRB- denotes (
T13965 3860-3863 CD denotes 100
T13966 3864-3866 NN denotes µg
T13967 3866-3867 -RRB- denotes )
T13968 3868-3871 VB denotes was
T13969 3872-3875 RB denotes not
T13970 3876-3885 JJ denotes effective
T13971 3885-3886 -COMMA- denotes ,
T13972 3887-3890 CC denotes but
T13973 3891-3897 NN denotes plasma
T13974 3898-3912 NN denotes concentrations
T13975 3913-3916 MD denotes may
T13976 3917-3919 VB denotes be
T13977 3920-3925 IN denotes below
T13978 3926-3931 DT denotes those
T13979 3932-3940 VB denotes required
T13980 3941-3944 IN denotes for
T13981 3945-3951 NN denotes GATA-3
T13982 3952-3962 NN denotes inhibition
T13983 3964-3971 RB denotes However
T13984 3971-3972 -COMMA- denotes ,
T13985 3973-3975 PRP denotes it
T13986 3976-3978 VB denotes is
T13987 3979-3985 JJ denotes likely
T13988 3986-3990 IN denotes that
T13989 3991-3994 DT denotes the
T13990 3995-4001 JJ denotes higher
T13991 4002-4016 NN denotes concentrations
T13992 4017-4019 IN denotes of
T13993 4020-4022 NN denotes FP
T13994 4023-4025 IN denotes in
T13995 4026-4029 DT denotes the
T13996 4030-4037 NN denotes airways
T13997 4038-4043 IN denotes after
T13998 4044-4051 VB denotes inhaled
T13999 4052-4066 NN denotes administration
T14000 4067-4072 MD denotes would
T14001 4073-4075 VB denotes be
T14002 4076-4085 JJ denotes effective
T14003 4086-4088 IN denotes in
T14004 4089-4099 VB denotes inhibiting
T14005 4100-4106 NN denotes GATA-3
T14006 4107-4109 IN denotes in
T14007 4110-4116 NN denotes airway
T14008 4117-4118 NN denotes T
T14009 4119-4124 NN denotes cells
T14010 4125-4127 IN denotes of
T14011 4128-4134 NN denotes asthma
T14012 4135-4143 NN denotes patients
T14013 4145-4148 DT denotes The
T14014 4149-4154 NN denotes study
T14015 4155-4157 IN denotes of
T14016 4158-4163 NN denotes PBMCs
T14017 4164-4168 IN denotes from
T14018 4169-4175 NN denotes asthma
T14019 4176-4184 NN denotes patients
T14020 4185-4192 VB denotes treated
T14021 4193-4197 IN denotes with
T14022 4198-4205 VB denotes inhaled
T14023 4206-4220 NN denotes corticosteroid
T14024 4221-4228 NN denotes therapy
T14025 4229-4236 RB denotes clearly
T14026 4237-4249 VB denotes demonstrates
T14027 4250-4254 IN denotes that
T14028 4255-4260 DT denotes these
T14029 4261-4270 JJ denotes molecular
T14030 4271-4281 NN denotes mechanisms
T14031 4282-4285 VB denotes are
T14032 4286-4292 JJ denotes likely
T14033 4293-4295 TO denotes to
T14034 4296-4300 RB denotes also
T14035 4301-4306 VB denotes occur
T14036 4307-4309 IN denotes in
T14037 4310-4318 NN denotes patients
T14038 4319-4321 IN denotes at
T14039 4322-4333 JJ denotes therapeutic
T14040 4334-4339 NN denotes doses
T14041 4340-4342 IN denotes of
T14042 4343-4350 VB denotes inhaled
T14043 4351-4366 NN denotes corticosteroids
T14044 4368-4370 IN denotes In
T14045 4371-4379 NN denotes addition
T14046 4379-4380 -COMMA- denotes ,
T14047 4381-4389 JJ denotes previous
T14048 4390-4397 NN denotes studies
T14049 4398-4402 VB denotes have
T14050 4403-4408 VB denotes shown
T14051 4409-4413 IN denotes that
T14052 4414-4429 NN denotes corticosteroids
T14053 4430-4433 MD denotes can
T14054 4434-4442 VB denotes suppress
T14055 4443-4447 NN denotes IL-4
T14056 4448-4451 CC denotes and
T14057 4452-4456 NN denotes IL-5
T14058 4457-4464 NN denotes release
T14059 4465-4469 IN denotes from
T14060 4470-4480 JJ denotes peripheral
T14061 4481-4486 NN denotes blood
T14062 4487-4492 NN denotes cells
T14063 4493-4495 IN denotes of
T14064 4496-4502 NN denotes asthma
T14065 4503-4511 NN denotes patients
T14066 4512-4514 FW denotes in
T14067 4515-4520 FW denotes vitro
T14068 4521-4524 CC denotes and
T14069 4525-4527 FW denotes in
T14070 4528-4532 FW denotes vivo
T14071 4533-4534 -LRB- denotes [
T14072 4534-4536 CD denotes 40
T14073 4536-4537 -RRB- denotes ]
T14074 4537-4538 CD denotes –
T14075 4538-4539 -LRB- denotes [
T14076 4539-4541 CD denotes 42
T14077 4541-4542 -RRB- denotes ]
T14078 4544-4546 IN denotes In
T14079 4547-4554 NN denotes summary
T14080 4554-4555 -COMMA- denotes ,
T14081 4556-4559 PRP-DOLLAR- denotes our
T14082 4560-4564 NN denotes data
T14083 4565-4572 VB denotes provide
T14084 4573-4581 NN denotes evidence
T14085 4582-4585 IN denotes for
T14086 4586-4587 DT denotes a
T14087 4588-4593 JJ denotes novel
T14088 4594-4600 NN denotes action
T14089 4601-4603 IN denotes of
T14090 4604-4619 NN denotes corticosteroids
T14091 4619-4620 -COLON- denotes :
T14092 4621-4632 NN denotes suppression
T14093 4633-4635 IN denotes of
T14094 4636-4644 JJ denotes allergic
T14095 4645-4657 NN denotes inflammation
T14096 4658-4665 IN denotes through
T14097 4666-4667 DT denotes a
T14098 4668-4673 JJ denotes rapid
T14099 4674-4684 JJ denotes inhibitory
T14100 4685-4691 NN denotes effect
T14101 4692-4694 IN denotes on
T14102 4695-4701 NN denotes GATA-3
T14103 4702-4709 JJ denotes nuclear
T14104 4710-4723 NN denotes translocation
T14105 4724-4726 IN denotes by
T14106 4727-4739 JJ denotes preferential
T14107 4740-4747 NN denotes binding
T14108 4748-4750 TO denotes to
T14109 4751-4754 DT denotes the
T14110 4755-4761 JJ denotes shared
T14111 4762-4769 JJ denotes nuclear
T14112 4770-4776 NN denotes import
T14113 4777-4784 NN denotes protein
T14114 4785-4795 NN denotes importin-α
T14115 4796-4799 CC denotes and
T14116 4800-4802 IN denotes by
T14117 4803-4804 DT denotes a
T14118 4805-4811 JJ denotes second
T14119 4812-4821 NN denotes mechanism
T14120 4822-4831 VB denotes involving
T14121 4832-4841 VB denotes increased
T14122 4842-4851 NN denotes synthesis
T14123 4852-4854 IN denotes of
T14124 4855-4860 NN denotes MKP-1
T14125 4860-4861 -COMMA- denotes ,
T14126 4862-4867 WDT denotes which
T14127 4868-4876 VB denotes inhibits
T14128 4877-4880 NN denotes p38
T14129 4881-4885 NN denotes MAPK
T14130 4885-4886 -COMMA- denotes ,
T14131 4887-4891 RB denotes thus
T14132 4892-4902 VB denotes preventing
T14133 4903-4906 DT denotes the
T14134 4907-4922 NN denotes phosphorylation
T14135 4923-4925 IN denotes of
T14136 4926-4932 NN denotes GATA-3
T14137 4933-4937 WDT denotes that
T14138 4938-4940 VB denotes is
T14139 4941-4950 JJ denotes necessary
T14140 4951-4954 IN denotes for
T14141 4955-4962 JJ denotes nuclear
T14142 4963-4976 NN denotes translocation
T14143 4977-4979 IN denotes of
T14144 4980-4986 NN denotes GATA-3
T14145 4988-4993 DT denotes These
T14146 4994-4997 CD denotes two
T14147 4998-5008 NN denotes mechanisms
T14148 5009-5012 VB denotes are
T14149 5013-5019 JJ denotes likely
T14150 5020-5022 TO denotes to
T14151 5023-5025 VB denotes be
T14152 5026-5037 JJ denotes synergistic
T14153 5037-5038 -COMMA- denotes ,
T14154 5039-5049 VB denotes accounting
T14155 5050-5053 IN denotes for
T14156 5054-5057 DT denotes the
T14157 5058-5063 JJ denotes rapid
T14158 5064-5067 CC denotes and
T14159 5068-5074 JJ denotes potent
T14160 5075-5081 NN denotes effect
T14161 5082-5084 IN denotes of
T14162 5085-5100 NN denotes corticosteroids
T14163 5101-5103 IN denotes on
T14164 5104-5112 JJ denotes allergic
T14165 5113-5125 NN denotes inflammation
T14166 5127-5131 DT denotes This
T14167 5132-5134 VB denotes is
T14168 5135-5146 VB denotes exemplified
T14169 5147-5149 IN denotes by
T14170 5150-5153 DT denotes the
T14171 5154-5159 JJ denotes rapid
T14172 5160-5170 JJ denotes inhibitory
T14173 5171-5177 NN denotes effect
T14174 5178-5180 IN denotes of
T14175 5181-5188 JJ denotes topical
T14176 5189-5204 NN denotes corticosteroids
T14177 5205-5207 IN denotes on
T14178 5208-5213 JJ denotes nasal
T14179 5214-5217 NN denotes Th2
T14180 5218-5226 NN denotes cytokine
T14181 5227-5234 NN denotes release
T14182 5235-5240 IN denotes after
T14183 5241-5249 NN denotes allergen
T14184 5250-5261 NN denotes provocation
T14185 5262-5264 IN denotes in
T14186 5265-5276 NN denotes individuals
T14187 5277-5281 IN denotes with
T14188 5282-5290 JJ denotes seasonal
T14189 5291-5299 JJ denotes allergic
T14190 5300-5308 NN denotes rhinitis
T14191 5309-5310 -LRB- denotes (
T14192 5310-5313 NN denotes hay
T14193 5314-5319 NN denotes fever
T14194 5319-5320 -RRB- denotes )
T14195 5321-5322 -LRB- denotes [
T14196 5322-5324 CD denotes 43
T14197 5324-5325 -RRB- denotes ]
T14198 5327-5337 NN denotes Prevention
T14199 5338-5340 IN denotes of
T14200 5341-5355 NN denotes phospho-GATA-3
T14201 5356-5367 NN denotes interaction
T14202 5368-5372 IN denotes with
T14203 5373-5383 NN denotes importin-α
T14204 5384-5387 MD denotes may
T14205 5388-5395 VB denotes provide
T14206 5396-5397 DT denotes a
T14207 5398-5401 JJ denotes new
T14208 5402-5410 NN denotes approach
T14209 5411-5414 IN denotes for
T14210 5415-5418 DT denotes the
T14211 5419-5430 NN denotes development
T14212 5431-5433 IN denotes of
T14213 5434-5439 JJ denotes novel
T14214 5440-5449 NN denotes therapies
T14215 5450-5453 IN denotes for
T14216 5454-5457 DT denotes the
T14217 5458-5467 NN denotes treatment
T14218 5468-5470 IN denotes of
T14219 5471-5479 JJ denotes allergic
T14220 5480-5488 NN denotes diseases
R11419 T13352 T13353 arg1Of we,have
R11420 T13352 T13354 arg1Of we,demonstrated
R11421 T13354 T13351 arg1Of demonstrated,Here
R11422 T13354 T13353 arg2Of demonstrated,have
R11423 T13354 T13355 arg1Of demonstrated,","
R11424 T13354 T13356 arg1Of demonstrated,to
R11425 T13354 T13363 arg1Of demonstrated,","
R11426 T13358 T13356 arg2Of knowledge,to
R11427 T13358 T13357 arg1Of knowledge,our
R11428 T13358 T13359 arg1Of knowledge,for
R11429 T13362 T13359 arg2Of time,for
R11430 T13362 T13360 arg1Of time,the
R11431 T13362 T13361 arg1Of time,first
R11432 T13365 T13366 arg1Of corticosteroids,may
R11433 T13365 T13367 arg1Of corticosteroids,inhibit
R11434 T13367 T13354 arg2Of inhibit,demonstrated
R11435 T13367 T13364 arg1Of inhibit,that
R11436 T13367 T13366 arg2Of inhibit,may
R11437 T13369 T13368 arg1Of function,GATA-3
R11438 T13369 T13370 arg1Of function,and
R11439 T13370 T13367 arg2Of and,inhibit
R11440 T13373 T13370 arg2Of transcription,and
R11441 T13373 T13371 arg1Of transcription,therefore
R11442 T13373 T13372 arg1Of transcription,the
R11443 T13373 T13374 arg1Of transcription,of
R11444 T13373 T13377 arg1Of transcription,via
R11445 T13376 T13374 arg2Of genes,of
R11446 T13376 T13375 arg1Of genes,Th2
R11447 T13379 T13380 arg1Of distinct,but
R11448 T13381 T13380 arg2Of interacting,but
R11449 T13383 T13377 arg2Of mechanisms,via
R11450 T13383 T13378 arg1Of mechanisms,two
R11451 T13383 T13379 arg1Of mechanisms,distinct
R11452 T13383 T13381 arg1Of mechanisms,interacting
R11453 T13383 T13382 arg1Of mechanisms,molecular
R11454 T13387 T13386 arg1Of GR,corticosteroid-activated
R11455 T13387 T13388 arg1Of GR,appears
R11456 T13387 T13390 arg1Of GR,compete
R11457 T13388 T13384 arg1Of appears,Firstly
R11458 T13388 T13385 arg1Of appears,","
R11459 T13390 T13388 arg2Of compete,appears
R11460 T13390 T13389 arg1Of compete,to
R11461 T13390 T13391 arg1Of compete,with
R11462 T13390 T13397 arg1Of compete,via
R11463 T13393 T13391 arg2Of GATA-3,with
R11464 T13393 T13392 arg2Of GATA-3,activated
R11465 T13393 T13394 arg1Of GATA-3,for
R11466 T13396 T13394 arg2Of import,for
R11467 T13396 T13395 arg1Of import,nuclear
R11468 T13398 T13397 arg2Of importin-α,via
R11469 T13398 T13399 arg1Of importin-α,","
R11470 T13398 T13400 arg1Of importin-α,which
R11471 T13398 T13401 arg1Of importin-α,is
R11472 T13398 T13402 arg2Of importin-α,required
R11473 T13402 T13401 arg2Of required,is
R11474 T13402 T13403 arg1Of required,for
R11475 T13406 T13403 arg2Of transport,for
R11476 T13406 T13404 arg1Of transport,the
R11477 T13406 T13405 arg1Of transport,nuclear
R11478 T13406 T13407 arg1Of transport,of
R11479 T13409 T13410 arg1Of GATA-3,and
R11480 T13410 T13407 arg2Of and,of
R11481 T13410 T13408 arg1Of and,both
R11482 T13411 T13410 arg2Of GR,and
R11483 T13414 T13415 arg1Of corticosteroids,at
R11484 T13414 T13418 arg1Of corticosteroids,increase
R11485 T13414 T13433 arg1Of corticosteroids,prevent
R11486 T13417 T13415 arg2Of concentrations,at
R11487 T13417 T13416 arg1Of concentrations,higher
R11488 T13418 T13431 arg1Of increase,and
R11489 T13420 T13418 arg2Of expression,increase
R11490 T13420 T13419 arg1Of expression,the
R11491 T13420 T13421 arg1Of expression,of
R11492 T13422 T13421 arg2Of MKP-1,of
R11493 T13422 T13423 arg1Of MKP-1,","
R11494 T13426 T13423 arg2Of inhibitor,","
R11495 T13426 T13424 arg1Of inhibitor,a
R11496 T13426 T13425 arg1Of inhibitor,potent
R11497 T13426 T13427 arg1Of inhibitor,of
R11498 T13430 T13427 arg2Of activity,of
R11499 T13430 T13428 arg1Of activity,p38
R11500 T13430 T13429 arg1Of activity,MAPK
R11501 T13431 T13412 arg1Of and,Secondly
R11502 T13431 T13413 arg1Of and,","
R11503 T13433 T13431 arg2Of prevent,and
R11504 T13433 T13432 arg1Of prevent,thereby
R11505 T13437 T13433 arg2Of activation,prevent
R11506 T13437 T13434 arg1Of activation,T
R11507 T13437 T13435 arg1Of activation,cell
R11508 T13437 T13436 arg1Of activation,receptor/co-receptor
R11509 T13437 T13438 arg1Of activation,of
R11510 T13437 T13441 modOf activation,to
R11511 T13440 T13438 arg2Of MAPK,of
R11512 T13440 T13439 arg1Of MAPK,p38
R11513 T13442 T13441 arg1Of prevent,to
R11514 T13444 T13442 arg2Of phosphorylation,prevent
R11515 T13444 T13443 arg1Of phosphorylation,the
R11516 T13444 T13445 arg1Of phosphorylation,of
R11517 T13444 T13447 arg1Of phosphorylation,that
R11518 T13444 T13448 arg1Of phosphorylation,is
R11519 T13444 T13449 arg1Of phosphorylation,necessary
R11520 T13446 T13445 arg2Of GATA-3,of
R11521 T13449 T13448 arg2Of necessary,is
R11522 T13449 T13450 arg1Of necessary,for
R11523 T13451 T13450 arg2Of interaction,for
R11524 T13451 T13452 arg1Of interaction,with
R11525 T13453 T13454 arg1Of importin-α,and
R11526 T13455 T13454 arg2Of subsequent,and
R11527 T13457 T13452 arg2Of import,with
R11528 T13457 T13453 arg1Of import,importin-α
R11529 T13457 T13455 arg1Of import,subsequent
R11530 T13457 T13456 arg1Of import,nuclear
R11531 T13458 T13459 arg1Of We,have
R11532 T13458 T13461 arg1Of We,shown
R11533 T13461 T13459 arg2Of shown,have
R11534 T13461 T13460 arg1Of shown,previously
R11535 T13463 T13464 arg1Of translocation,of
R11536 T13463 T13469 arg1Of translocation,to
R11537 T13463 T13472 arg1Of translocation,involves
R11538 T13465 T13464 arg2Of GATA-3,of
R11539 T13465 T13466 arg1Of GATA-3,from
R11540 T13468 T13466 arg2Of cytoplasm,from
R11541 T13468 T13467 arg1Of cytoplasm,the
R11542 T13471 T13469 arg2Of nucleus,to
R11543 T13471 T13470 arg1Of nucleus,the
R11544 T13472 T13461 arg2Of involves,shown
R11545 T13472 T13462 arg1Of involves,that
R11546 T13477 T13472 arg2Of importin-α,involves
R11547 T13477 T13473 arg1Of importin-α,the
R11548 T13477 T13474 arg1Of importin-α,nuclear
R11549 T13477 T13475 arg1Of importin-α,transporter
R11550 T13477 T13476 arg1Of importin-α,protein
R11551 T13477 T13478 arg1Of importin-α,","
R11552 T13477 T13479 arg1Of importin-α,which
R11553 T13477 T13480 arg1Of importin-α,interacts
R11554 T13480 T13481 arg1Of interacts,with
R11555 T13480 T13484 arg1Of interacts,[
R11556 T13483 T13481 arg2Of GATA-3,with
R11557 T13483 T13482 arg2Of GATA-3,phosphorylated
R11558 T13485 T13484 arg2Of 12,[
R11559 T13486 T13484 arg3Of ],[
R11560 T13487 T13488 arg1Of We,have
R11561 T13487 T13491 arg1Of We,reported
R11562 T13491 T13488 arg2Of reported,have
R11563 T13491 T13489 arg1Of reported,also
R11564 T13491 T13490 arg1Of reported,previously
R11565 T13494 T13493 arg1Of knockdown,GATA-3
R11566 T13494 T13495 arg1Of knockdown,using
R11567 T13494 T13497 arg1Of knockdown,results
R11568 T13496 T13495 arg2Of siRNA,using
R11569 T13497 T13491 arg2Of results,reported
R11570 T13497 T13492 arg1Of results,that
R11571 T13497 T13498 arg1Of results,in
R11572 T13497 T13505 arg1Of results,","
R11573 T13497 T13507 modOf results,implicating
R11574 T13499 T13498 arg2Of suppression,in
R11575 T13499 T13500 arg1Of suppression,of
R11576 T13504 T13500 arg2Of induction,of
R11577 T13504 T13501 arg1Of induction,anti-CD3/CD28–stimulated
R11578 T13504 T13502 arg1Of induction,IL-4/IL-5
R11579 T13504 T13503 arg1Of induction,mRNA
R11580 T13507 T13506 arg1Of implicating,thus
R11581 T13507 T13519 arg1Of implicating,[
R11582 T13510 T13507 arg2Of role,implicating
R11583 T13510 T13508 arg1Of role,an
R11584 T13510 T13509 arg1Of role,essential
R11585 T13510 T13511 arg1Of role,for
R11586 T13510 T13513 arg1Of role,in
R11587 T13512 T13511 arg2Of GATA-3,for
R11588 T13515 T13513 arg2Of transcription,in
R11589 T13515 T13514 arg1Of transcription,the
R11590 T13515 T13516 arg1Of transcription,of
R11591 T13518 T13516 arg2Of genes,of
R11592 T13518 T13517 arg1Of genes,these
R11593 T13520 T13519 arg2Of 12,[
R11594 T13521 T13519 arg3Of ],[
R11595 T13522 T13524 arg1Of We,confirm
R11596 T13524 T13523 arg1Of confirm,now
R11597 T13524 T13525 arg1Of confirm,","
R11598 T13524 T13526 arg1Of confirm,in
R11599 T13524 T13530 arg1Of confirm,","
R11600 T13529 T13526 arg2Of cells,in
R11601 T13529 T13527 arg1Of cells,human
R11602 T13529 T13528 arg1Of cells,T
R11603 T13532 T13534 arg1Of GR,uses
R11604 T13534 T13524 arg2Of uses,confirm
R11605 T13534 T13531 arg1Of uses,that
R11606 T13534 T13533 arg1Of uses,also
R11607 T13534 T13540 arg1Of uses,as
R11608 T13534 T13542 arg1Of uses,[
R11609 T13539 T13534 arg2Of mechanism,uses
R11610 T13539 T13535 arg1Of mechanism,the
R11611 T13539 T13536 arg1Of mechanism,same
R11612 T13539 T13537 arg1Of mechanism,nuclear
R11613 T13539 T13538 arg1Of mechanism,import
R11614 T13541 T13540 arg2Of GATA-3,as
R11615 T13543 T13542 arg2Of 22,[
R11616 T13544 T13542 arg3Of ],[
R11617 T13545 T13547 arg1Of We,propose
R11618 T13547 T13546 arg1Of propose,therefore
R11619 T13549 T13550 arg1Of there,is
R11620 T13550 T13547 arg2Of is,propose
R11621 T13550 T13548 arg1Of is,that
R11622 T13551 T13550 arg2Of competition,is
R11623 T13551 T13552 arg1Of competition,between
R11624 T13551 T13557 arg1Of competition,for
R11625 T13554 T13555 arg1Of GR,and
R11626 T13555 T13552 arg2Of and,between
R11627 T13555 T13553 arg1Of and,ligand-activated
R11628 T13556 T13555 arg2Of phospho-GATA-3,and
R11629 T13559 T13557 arg2Of import,for
R11630 T13559 T13558 arg1Of import,nuclear
R11631 T13562 T13563 arg1Of we,have
R11632 T13562 T13564 arg1Of we,shown
R11633 T13564 T13560 arg1Of shown,Furthermore
R11634 T13564 T13561 arg1Of shown,","
R11635 T13564 T13563 arg2Of shown,have
R11636 T13566 T13567 arg1Of there,is
R11637 T13567 T13564 arg2Of is,shown
R11638 T13567 T13565 arg1Of is,that
R11639 T13567 T13577 arg1Of is,","
R11640 T13567 T13578 arg1Of is,so
R11641 T13569 T13567 arg2Of binding,is
R11642 T13569 T13568 arg1Of binding,preferential
R11643 T13569 T13570 arg1Of binding,of
R11644 T13569 T13572 arg1Of binding,to
R11645 T13569 T13575 arg1Of binding,over
R11646 T13571 T13570 arg2Of importin-α,of
R11647 T13574 T13572 arg2Of GR,to
R11648 T13574 T13573 arg2Of GR,activated
R11649 T13576 T13575 arg2Of phospho-GATA-3,over
R11650 T13578 T13579 arg1Of so,that
R11651 T13580 T13581 arg1Of corticosteroids,would
R11652 T13580 T13583 arg1Of corticosteroids,reduce
R11653 T13580 T13589 arg1Of corticosteroids,switch
R11654 T13583 T13586 arg1Of reduce,and
R11655 T13585 T13583 arg2Of entry,reduce
R11656 T13585 T13584 arg1Of entry,GATA-3
R11657 T13586 T13578 arg2Of and,so
R11658 T13586 T13581 arg2Of and,would
R11659 T13586 T13582 arg1Of and,preferentially
R11660 T13589 T13586 arg2Of switch,and
R11661 T13589 T13587 arg1Of switch,thus
R11662 T13589 T13588 arg1Of switch,rapidly
R11663 T13589 T13590 arg1Of switch,off
R11664 T13589 T13594 arg1Of switch,without
R11665 T13593 T13589 arg2Of transcription,switch
R11666 T13593 T13591 arg1Of transcription,Th2
R11667 T13593 T13592 arg1Of transcription,gene
R11668 T13596 T13594 arg2Of need,without
R11669 T13596 T13595 arg1Of need,any
R11670 T13596 T13597 arg1Of need,for
R11671 T13600 T13597 arg2Of steps,for
R11672 T13600 T13598 arg1Of steps,any
R11673 T13600 T13599 arg1Of steps,intermediate
R11674 T13603 T13604 arg1Of there,was
R11675 T13604 T13601 arg1Of was,Furthermore
R11676 T13604 T13602 arg1Of was,","
R11677 T13604 T13611 arg1Of was,","
R11678 T13604 T13612 arg1Of was,as
R11679 T13606 T13604 arg2Of degree,was
R11680 T13606 T13605 arg1Of degree,some
R11681 T13606 T13607 arg1Of degree,of
R11682 T13606 T13609 arg1Of degree,for
R11683 T13608 T13607 arg2Of specificity,of
R11684 T13610 T13609 arg2Of GATA-3,for
R11685 T13614 T13613 arg1Of translocation,nuclear
R11686 T13614 T13615 arg1Of translocation,of
R11687 T13614 T13621 arg1Of translocation,was
R11688 T13614 T13623 arg2Of translocation,affected
R11689 T13618 T13615 arg2Of subunit,of
R11690 T13618 T13616 arg1Of subunit,the
R11691 T13618 T13617 arg1Of subunit,p65
R11692 T13618 T13619 arg1Of subunit,of
R11693 T13620 T13619 arg2Of NF-κB,of
R11694 T13623 T13612 arg2Of affected,as
R11695 T13623 T13621 arg2Of affected,was
R11696 T13623 T13622 arg1Of affected,not
R11697 T13626 T13623 arg1Of exposure,affected
R11698 T13626 T13624 arg2Of exposure,by
R11699 T13626 T13625 arg1Of exposure,corticosteroid
R11700 T13627 T13628 arg1Of We,tested
R11701 T13627 T13642 arg1Of We,failed
R11702 T13627 T13644 arg1Of We,show
R11703 T13628 T13641 arg1Of tested,and
R11704 T13631 T13628 arg2Of explanations,tested
R11705 T13631 T13629 arg1Of explanations,some
R11706 T13631 T13630 arg1Of explanations,alternative
R11707 T13631 T13632 arg1Of explanations,for
R11708 T13634 T13632 arg2Of effect,for
R11709 T13634 T13633 arg1Of effect,this
R11710 T13634 T13635 arg1Of effect,of
R11711 T13634 T13637 arg1Of effect,on
R11712 T13636 T13635 arg2Of FP,of
R11713 T13640 T13637 arg2Of exclusion,on
R11714 T13640 T13638 arg1Of exclusion,GATA-3
R11715 T13640 T13639 arg1Of exclusion,nuclear
R11716 T13642 T13641 arg2Of failed,and
R11717 T13644 T13642 arg2Of show,failed
R11718 T13644 T13643 arg1Of show,to
R11719 T13646 T13648 arg1Of FP,enhances
R11720 T13646 T13654 arg1Of FP,induces
R11721 T13648 T13647 arg1Of enhances,either
R11722 T13648 T13652 arg1Of enhances,directly
R11723 T13648 T13653 arg1Of enhances,or
R11724 T13651 T13648 arg2Of export,enhances
R11725 T13651 T13649 arg1Of export,GATA-3
R11726 T13651 T13650 arg1Of export,nuclear
R11727 T13653 T13644 arg2Of or,show
R11728 T13653 T13645 arg1Of or,that
R11729 T13654 T13653 arg2Of induces,or
R11730 T13656 T13654 arg2Of degradation,induces
R11731 T13656 T13655 arg1Of degradation,GATA-3
R11732 T13658 T13657 arg1Of evidence,The
R11733 T13658 T13659 arg1Of evidence,from
R11734 T13658 T13665 arg1Of evidence,does
R11735 T13658 T13669 arg1Of evidence,suggest
R11736 T13662 T13661 arg1Of vitro,in
R11737 T13664 T13659 arg2Of assays,from
R11738 T13664 T13660 arg1Of assays,the
R11739 T13664 T13662 arg1Of assays,vitro
R11740 T13664 T13663 arg1Of assays,competition
R11741 T13669 T13665 arg2Of suggest,does
R11742 T13669 T13666 arg1Of suggest,","
R11743 T13669 T13667 arg1Of suggest,however
R11744 T13669 T13668 arg1Of suggest,","
R11745 T13673 T13671 arg2Of GR,purified
R11746 T13673 T13672 arg2Of GR,activated
R11747 T13673 T13674 arg1Of GR,can
R11748 T13673 T13676 arg1Of GR,attenuate
R11749 T13676 T13670 arg1Of attenuate,that
R11750 T13676 T13674 arg2Of attenuate,can
R11751 T13676 T13675 arg1Of attenuate,clearly
R11752 T13676 T13680 arg1Of attenuate,and
R11753 T13679 T13676 arg2Of association,attenuate
R11754 T13679 T13677 arg2Of association,purified
R11755 T13679 T13678 arg1Of association,phospho-GATA-3–importin-α
R11756 T13680 T13669 arg2Of and,suggest
R11757 T13681 T13680 arg2Of that,and
R11758 T13683 T13682 arg1Of converse,the
R11759 T13683 T13684 arg1Of converse,does
R11760 T13683 T13686 arg1Of converse,occur
R11761 T13686 T13681 arg2Of occur,that
R11762 T13686 T13684 arg2Of occur,does
R11763 T13686 T13685 arg1Of occur,not
R11764 T13689 T13690 arg1Of we,have
R11765 T13689 T13691 arg1Of we,shown
R11766 T13691 T13687 arg1Of shown,Furthermore
R11767 T13691 T13688 arg1Of shown,","
R11768 T13691 T13690 arg2Of shown,have
R11769 T13694 T13693 arg1Of phospho-GATA-3,only
R11770 T13694 T13695 arg1Of phospho-GATA-3,can
R11771 T13694 T13696 arg1Of phospho-GATA-3,associate
R11772 T13696 T13691 arg2Of associate,shown
R11773 T13696 T13692 arg1Of associate,that
R11774 T13696 T13695 arg2Of associate,can
R11775 T13696 T13697 arg1Of associate,with
R11776 T13698 T13697 arg2Of importin-α,with
R11777 T13700 T13699 arg1Of mechanism,This
R11778 T13700 T13701 arg1Of mechanism,is
R11779 T13700 T13702 arg1Of mechanism,sensitive
R11780 T13700 T13710 arg1Of mechanism,would
R11781 T13700 T13711 arg1Of mechanism,be
R11782 T13700 T13712 arg1Of mechanism,rapid
R11783 T13701 T13709 arg1Of is,and
R11784 T13702 T13701 arg2Of sensitive,is
R11785 T13702 T13703 arg1Of sensitive,to
R11786 T13705 T13704 arg1Of low,very
R11787 T13706 T13703 arg2Of concentrations,to
R11788 T13706 T13705 arg1Of concentrations,low
R11789 T13706 T13707 arg1Of concentrations,of
R11790 T13708 T13707 arg2Of corticosteroid,of
R11791 T13711 T13709 arg2Of be,and
R11792 T13711 T13710 arg2Of be,would
R11793 T13711 T13713 arg1Of be,in
R11794 T13711 T13715 arg1Of be,as
R11795 T13712 T13711 arg2Of rapid,be
R11796 T13714 T13713 arg2Of onset,in
R11797 T13717 T13716 arg1Of changes,no
R11798 T13717 T13718 arg1Of changes,in
R11799 T13717 T13721 arg1Of changes,are
R11800 T13717 T13722 arg2Of changes,required
R11801 T13720 T13718 arg2Of synthesis,in
R11802 T13720 T13719 arg1Of synthesis,protein
R11803 T13722 T13715 arg2Of required,as
R11804 T13722 T13721 arg2Of required,are
R11805 T13725 T13723 arg1Of mechanism,This
R11806 T13725 T13724 arg1Of mechanism,acute
R11807 T13725 T13726 arg1Of mechanism,may
R11808 T13725 T13728 arg1Of mechanism,contribute
R11809 T13725 T13737 arg1Of mechanism,may
R11810 T13725 T13738 arg1Of mechanism,play
R11811 T13728 T13726 arg2Of contribute,may
R11812 T13728 T13727 arg1Of contribute,also
R11813 T13728 T13729 arg1Of contribute,to
R11814 T13728 T13736 arg1Of contribute,and
R11815 T13731 T13729 arg2Of reduction,to
R11816 T13731 T13730 arg1Of reduction,the
R11817 T13731 T13732 arg1Of reduction,in
R11818 T13735 T13732 arg2Of import,in
R11819 T13735 T13733 arg1Of import,GATA-3
R11820 T13735 T13734 arg1Of import,nuclear
R11821 T13738 T13736 arg2Of play,and
R11822 T13738 T13737 arg2Of play,may
R11823 T13738 T13742 arg1Of play,at
R11824 T13738 T13747 arg1Of play,at
R11825 T13741 T13738 arg2Of role,play
R11826 T13741 T13739 arg1Of role,a
R11827 T13741 T13740 arg1Of role,major
R11828 T13742 T13746 arg1Of at,and/or
R11829 T13745 T13742 arg2Of concentrations,at
R11830 T13745 T13743 arg1Of concentrations,low
R11831 T13745 T13744 arg1Of concentrations,corticosteroid
R11832 T13747 T13746 arg2Of at,and/or
R11833 T13750 T13747 arg2Of points,at
R11834 T13750 T13748 arg1Of points,early
R11835 T13750 T13749 arg1Of points,time
R11836 T13750 T13751 arg1Of points,prior
R11837 T13751 T13752 arg1Of prior,to
R11838 T13754 T13752 arg2Of induction,to
R11839 T13754 T13753 arg1Of induction,MKP-1
R11840 T13755 T13756 arg1Of Corticosteroids,can
R11841 T13755 T13757 arg1Of Corticosteroids,modulate
R11842 T13757 T13756 arg2Of modulate,can
R11843 T13757 T13761 arg1Of modulate,through
R11844 T13757 T13777 arg1Of modulate,","
R11845 T13757 T13778 arg1Of modulate,[
R11846 T13760 T13757 arg2Of activity,modulate
R11847 T13760 T13758 arg1Of activity,p38
R11848 T13760 T13759 arg1Of activity,MAPK
R11849 T13763 T13761 arg2Of induction,through
R11850 T13763 T13762 arg1Of induction,the
R11851 T13763 T13764 arg1Of induction,of
R11852 T13763 T13766 arg1Of induction,","
R11853 T13765 T13764 arg2Of MKP-1,of
R11854 T13770 T13766 arg2Of inhibitor,","
R11855 T13770 T13767 arg1Of inhibitor,a
R11856 T13770 T13768 arg1Of inhibitor,potent
R11857 T13770 T13769 arg1Of inhibitor,endogenous
R11858 T13770 T13771 arg1Of inhibitor,of
R11859 T13773 T13771 arg2Of function,of
R11860 T13773 T13772 arg1Of function,MAPK
R11861 T13773 T13774 arg1Of function,[
R11862 T13775 T13774 arg2Of 38,[
R11863 T13776 T13774 arg3Of ],[
R11864 T13779 T13778 arg2Of 39,[
R11865 T13780 T13778 arg3Of ],[
R11866 T13781 T13782 arg1Of We,report
R11867 T13782 T13783 arg1Of report,here
R11868 T13786 T13782 arg2Of induction,report
R11869 T13786 T13784 arg1Of induction,a
R11870 T13786 T13785 arg1Of induction,rapid
R11871 T13786 T13787 arg1Of induction,of
R11872 T13786 T13790 arg1Of induction,following
R11873 T13789 T13787 arg2Of mRNA,of
R11874 T13789 T13788 arg1Of mRNA,MKP-1
R11875 T13791 T13790 arg2Of stimulation,following
R11876 T13791 T13792 arg1Of stimulation,of
R11877 T13791 T13794 arg1Of stimulation,with
R11878 T13793 T13792 arg2Of cells,of
R11879 T13796 T13795 arg1Of high,relatively
R11880 T13797 T13794 arg2Of concentrations,with
R11881 T13797 T13796 arg1Of concentrations,high
R11882 T13797 T13798 arg1Of concentrations,of
R11883 T13799 T13798 arg2Of FP,of
R11884 T13800 T13801 arg1Of We,hypothesize
R11885 T13805 T13803 arg1Of induction,this
R11886 T13805 T13804 arg1Of induction,rapid
R11887 T13805 T13806 arg1Of induction,of
R11888 T13805 T13808 arg1Of induction,can
R11889 T13805 T13809 arg1Of induction,reduce
R11890 T13805 T13814 arg1Of induction,attenuating
R11891 T13805 T13824 arg1Of induction,preventing
R11892 T13807 T13806 arg2Of MKP-1,of
R11893 T13809 T13801 arg2Of reduce,hypothesize
R11894 T13809 T13802 arg1Of reduce,that
R11895 T13809 T13808 arg2Of reduce,can
R11896 T13809 T13813 arg1Of reduce,by
R11897 T13812 T13809 arg2Of import,reduce
R11898 T13812 T13810 arg1Of import,GATA-3
R11899 T13812 T13811 arg1Of import,nuclear
R11900 T13814 T13822 arg1Of attenuating,","
R11901 T13817 T13815 arg1Of activity,p38
R11902 T13817 T13816 arg1Of activity,MAPK
R11903 T13817 T13818 arg1Of activity,and
R11904 T13818 T13814 arg2Of and,attenuating
R11905 T13821 T13818 arg2Of phosphorylation,and
R11906 T13821 T13819 arg1Of phosphorylation,subsequent
R11907 T13821 T13820 arg1Of phosphorylation,GATA-3
R11908 T13822 T13813 arg2Of ",",by
R11909 T13824 T13822 arg2Of preventing,","
R11910 T13824 T13823 arg1Of preventing,thus
R11911 T13826 T13824 arg2Of translocation,preventing
R11912 T13826 T13825 arg1Of translocation,nuclear
R11913 T13828 T13827 arg1Of location,The
R11914 T13828 T13829 arg1Of location,of
R11915 T13828 T13838 arg1Of location,that
R11916 T13828 T13839 arg1Of location,are
R11917 T13828 T13840 arg2Of location,phosphorylated
R11918 T13828 T13844 arg1Of location,are
R11919 T13828 T13846 arg1Of location,unknown
R11920 T13832 T13829 arg2Of residue,of
R11921 T13832 T13830 arg1Of residue,the
R11922 T13832 T13831 arg1Of residue,serine
R11923 T13832 T13833 arg1Of residue,(
R11924 T13832 T13836 arg1Of residue,of
R11925 T13834 T13833 arg2Of s,(
R11926 T13835 T13833 arg3Of ),(
R11927 T13837 T13836 arg2Of GATA-3,of
R11928 T13840 T13839 arg2Of phosphorylated,are
R11929 T13843 T13840 arg1Of MAPK,phosphorylated
R11930 T13843 T13841 arg2Of MAPK,by
R11931 T13843 T13842 arg1Of MAPK,p38
R11932 T13844 T13845 arg1Of are,currently
R11933 T13844 T13848 arg1Of are,but
R11934 T13846 T13844 arg2Of unknown,are
R11935 T13848 T13847 arg1Of but,","
R11936 T13854 T13849 arg1Of Scanner,a
R11937 T13854 T13850 arg1Of Scanner,bioinformatics
R11938 T13854 T13851 arg1Of Scanner,search
R11939 T13854 T13852 arg1Of Scanner,(
R11940 T13854 T13853 arg1Of Scanner,Motif
R11941 T13854 T13855 arg1Of Scanner,","
R11942 T13854 T13860 arg1Of Scanner,indicates
R11943 T13856 T13855 arg2Of http,","
R11944 T13856 T13857 arg1Of http,:
R11945 T13858 T13859 arg1Of //scansite.mit.edu/motifscan_seq.phtml,)
R11946 T13860 T13848 arg2Of indicates,but
R11947 T13860 T13858 arg1Of indicates,//scansite.mit.edu/motifscan_seq.phtml
R11948 T13863 T13861 arg1Of three,at
R11949 T13863 T13862 arg1Of three,least
R11950 T13868 T13860 arg2Of residues,indicates
R11951 T13868 T13863 arg1Of residues,three
R11952 T13868 T13864 arg1Of residues,potential
R11953 T13868 T13865 arg1Of residues,p38
R11954 T13868 T13866 arg1Of residues,MAPK-sensitive
R11955 T13868 T13867 arg1Of residues,serine
R11956 T13870 T13869 arg2Of predicted,As
R11957 T13870 T13871 arg1Of predicted,from
R11958 T13874 T13873 arg1Of vitro,in
R11959 T13875 T13871 arg2Of data,from
R11960 T13875 T13872 arg1Of data,these
R11961 T13875 T13874 arg1Of data,vitro
R11962 T13877 T13878 arg1Of impairment,of
R11963 T13877 T13882 arg1Of impairment,by
R11964 T13877 T13884 arg1Of impairment,may
R11965 T13877 T13891 arg1Of impairment,underlie
R11966 T13881 T13878 arg2Of import,of
R11967 T13881 T13879 arg1Of import,GATA-3
R11968 T13881 T13880 arg1Of import,nuclear
R11969 T13883 T13882 arg2Of FP,by
R11970 T13887 T13886 arg1Of least,at
R11971 T13888 T13887 arg1Of in,least
R11972 T13889 T13888 arg2Of part,in
R11973 T13890 T13869 arg1Of ",",As
R11974 T13890 T13876 arg1Of ",",","
R11975 T13891 T13890 arg2Of underlie,","
R11976 T13893 T13891 arg2Of efficacy,underlie
R11977 T13893 T13892 arg1Of efficacy,the
R11978 T13893 T13894 arg1Of efficacy,of
R11979 T13893 T13896 arg1Of efficacy,in
R11980 T13895 T13894 arg2Of corticosteroids,of
R11981 T13897 T13896 arg2Of suppressing,in
R11982 T13899 T13897 arg2Of inflammation,suppressing
R11983 T13899 T13898 arg1Of inflammation,allergic
R11984 T13901 T13902 arg1Of we,did
R11985 T13901 T13904 arg1Of we,assess
R11986 T13904 T13900 arg2Of assess,Although
R11987 T13904 T13902 arg2Of assess,did
R11988 T13904 T13903 arg1Of assess,not
R11989 T13904 T13918 arg1Of assess,vivo
R11990 T13907 T13906 arg1Of inhibitory,acute
R11991 T13908 T13904 arg2Of effect,assess
R11992 T13908 T13905 arg1Of effect,the
R11993 T13908 T13907 arg1Of effect,inhibitory
R11994 T13908 T13909 arg1Of effect,of
R11995 T13908 T13911 arg1Of effect,on
R11996 T13910 T13909 arg2Of FP,of
R11997 T13913 T13911 arg2Of expression,on
R11998 T13913 T13912 arg1Of expression,the
R11999 T13913 T13914 arg1Of expression,of
R12000 T13916 T13914 arg2Of mRNA,of
R12001 T13916 T13915 arg1Of mRNA,IL-4
R12002 T13918 T13917 arg1Of vivo,in
R12003 T13922 T13920 arg1Of inhalation,a
R12004 T13922 T13921 arg1Of inhalation,single
R12005 T13922 T13923 arg1Of inhalation,of
R12006 T13922 T13929 arg1Of inhalation,may
R12007 T13922 T13930 arg1Of inhalation,have
R12008 T13924 T13923 arg2Of FP,of
R12009 T13924 T13925 arg1Of FP,(
R12010 T13927 T13925 arg2Of µg,(
R12011 T13927 T13926 arg1Of µg,500
R12012 T13928 T13925 arg3Of ),(
R12013 T13930 T13900 arg1Of have,Although
R12014 T13930 T13919 arg1Of have,","
R12015 T13930 T13929 arg2Of have,may
R12016 T13930 T13933 arg1Of have,","
R12017 T13930 T13934 arg1Of have,as
R12018 T13932 T13930 arg2Of effects,have
R12019 T13932 T13931 arg1Of effects,comparable
R12020 T13935 T13936 arg1Of it,provides
R12021 T13936 T13934 arg2Of provides,as
R12022 T13936 T13939 arg1Of provides,within
R12023 T13938 T13936 arg2Of levels,provides
R12024 T13938 T13937 arg1Of levels,plasma
R12025 T13942 T13939 arg2Of range,within
R12026 T13942 T13940 arg1Of range,a
R12027 T13942 T13941 arg1Of range,relevant
R12028 T13942 T13943 arg1Of range,of
R12029 T13944 T13943 arg2Of concentrations,of
R12030 T13944 T13945 arg2Of concentrations,used
R12031 T13947 T13945 arg3Of suppress,used
R12032 T13947 T13946 arg1Of suppress,to
R12033 T13947 T13950 arg1Of suppress,in
R12034 T13949 T13947 arg2Of transcription,suppress
R12035 T13949 T13948 arg1Of transcription,IL-4
R12036 T13953 T13952 arg1Of vitro,in
R12037 T13954 T13950 arg2Of system,in
R12038 T13954 T13951 arg1Of system,our
R12039 T13954 T13953 arg1Of system,vitro
R12040 T13954 T13955 arg1Of system,[
R12041 T13956 T13955 arg2Of 37,[
R12042 T13957 T13955 arg3Of ],[
R12043 T13960 T13958 arg1Of dose,A
R12044 T13960 T13959 arg1Of dose,lower
R12045 T13960 T13961 arg1Of dose,of
R12046 T13960 T13968 arg1Of dose,was
R12047 T13960 T13970 arg1Of dose,effective
R12048 T13963 T13961 arg2Of FP,of
R12049 T13963 T13962 arg2Of FP,inhaled
R12050 T13963 T13964 arg1Of FP,(
R12051 T13966 T13964 arg2Of µg,(
R12052 T13966 T13965 arg1Of µg,100
R12053 T13967 T13964 arg3Of ),(
R12054 T13968 T13969 arg1Of was,not
R12055 T13968 T13972 arg1Of was,but
R12056 T13970 T13968 arg2Of effective,was
R12057 T13972 T13971 arg1Of but,","
R12058 T13974 T13973 arg1Of concentrations,plasma
R12059 T13974 T13975 arg1Of concentrations,may
R12060 T13974 T13976 arg1Of concentrations,be
R12061 T13974 T13977 arg1Of concentrations,below
R12062 T13976 T13972 arg2Of be,but
R12063 T13976 T13975 arg2Of be,may
R12064 T13977 T13976 arg2Of below,be
R12065 T13978 T13977 arg2Of those,below
R12066 T13978 T13979 arg2Of those,required
R12067 T13979 T13980 arg1Of required,for
R12068 T13982 T13980 arg2Of inhibition,for
R12069 T13982 T13981 arg1Of inhibition,GATA-3
R12070 T13985 T13986 arg1Of it,is
R12071 T13985 T13987 arg1Of it,likely
R12072 T13986 T13983 arg1Of is,However
R12073 T13986 T13984 arg1Of is,","
R12074 T13987 T13986 arg2Of likely,is
R12075 T13991 T13989 arg1Of concentrations,the
R12076 T13991 T13990 arg1Of concentrations,higher
R12077 T13991 T13992 arg1Of concentrations,of
R12078 T13991 T13994 arg1Of concentrations,in
R12079 T13991 T14000 arg1Of concentrations,would
R12080 T13991 T14001 arg1Of concentrations,be
R12081 T13991 T14002 arg1Of concentrations,effective
R12082 T13993 T13992 arg2Of FP,of
R12083 T13996 T13994 arg2Of airways,in
R12084 T13996 T13995 arg1Of airways,the
R12085 T13996 T13997 arg1Of airways,after
R12086 T13999 T13997 arg2Of administration,after
R12087 T13999 T13998 arg2Of administration,inhaled
R12088 T14001 T13987 arg2Of be,likely
R12089 T14001 T13988 arg1Of be,that
R12090 T14001 T14000 arg2Of be,would
R12091 T14002 T14001 arg2Of effective,be
R12092 T14002 T14003 arg1Of effective,in
R12093 T14004 T14003 arg2Of inhibiting,in
R12094 T14004 T14006 arg1Of inhibiting,in
R12095 T14005 T14004 arg2Of GATA-3,inhibiting
R12096 T14009 T14006 arg2Of cells,in
R12097 T14009 T14007 arg1Of cells,airway
R12098 T14009 T14008 arg1Of cells,T
R12099 T14009 T14010 arg1Of cells,of
R12100 T14012 T14010 arg2Of patients,of
R12101 T14012 T14011 arg1Of patients,asthma
R12102 T14014 T14013 arg1Of study,The
R12103 T14014 T14015 arg1Of study,of
R12104 T14014 T14026 arg1Of study,demonstrates
R12105 T14016 T14015 arg2Of PBMCs,of
R12106 T14016 T14017 arg1Of PBMCs,from
R12107 T14019 T14017 arg2Of patients,from
R12108 T14019 T14018 arg1Of patients,asthma
R12109 T14019 T14020 arg2Of patients,treated
R12110 T14020 T14021 arg1Of treated,with
R12111 T14024 T14021 arg2Of therapy,with
R12112 T14024 T14022 arg2Of therapy,inhaled
R12113 T14024 T14023 arg1Of therapy,corticosteroid
R12114 T14026 T14025 arg1Of demonstrates,clearly
R12115 T14030 T14028 arg1Of mechanisms,these
R12116 T14030 T14029 arg1Of mechanisms,molecular
R12117 T14030 T14031 arg1Of mechanisms,are
R12118 T14030 T14032 arg1Of mechanisms,likely
R12119 T14030 T14035 arg1Of mechanisms,occur
R12120 T14031 T14026 arg2Of are,demonstrates
R12121 T14031 T14027 arg1Of are,that
R12122 T14032 T14031 arg2Of likely,are
R12123 T14035 T14032 arg2Of occur,likely
R12124 T14035 T14033 arg1Of occur,to
R12125 T14035 T14034 arg1Of occur,also
R12126 T14035 T14036 arg1Of occur,in
R12127 T14037 T14036 arg2Of patients,in
R12128 T14037 T14038 arg1Of patients,at
R12129 T14040 T14038 arg2Of doses,at
R12130 T14040 T14039 arg1Of doses,therapeutic
R12131 T14040 T14041 arg1Of doses,of
R12132 T14043 T14041 arg2Of corticosteroids,of
R12133 T14043 T14042 arg2Of corticosteroids,inhaled
R12134 T14045 T14044 arg2Of addition,In
R12135 T14048 T14047 arg1Of studies,previous
R12136 T14048 T14049 arg1Of studies,have
R12137 T14048 T14050 arg1Of studies,shown
R12138 T14050 T14044 arg1Of shown,In
R12139 T14050 T14046 arg1Of shown,","
R12140 T14050 T14049 arg2Of shown,have
R12141 T14052 T14053 arg1Of corticosteroids,can
R12142 T14052 T14054 arg1Of corticosteroids,suppress
R12143 T14054 T14050 arg2Of suppress,shown
R12144 T14054 T14051 arg1Of suppress,that
R12145 T14054 T14053 arg2Of suppress,can
R12146 T14055 T14056 arg1Of IL-4,and
R12147 T14057 T14056 arg2Of IL-5,and
R12148 T14058 T14055 arg1Of release,IL-4
R12149 T14058 T14057 arg1Of release,IL-5
R12150 T14058 T14059 arg1Of release,from
R12151 T14058 T14067 arg1Of release,vitro
R12152 T14058 T14068 arg1Of release,and
R12153 T14062 T14059 arg2Of cells,from
R12154 T14062 T14060 arg1Of cells,peripheral
R12155 T14062 T14061 arg1Of cells,blood
R12156 T14062 T14063 arg1Of cells,of
R12157 T14065 T14063 arg2Of patients,of
R12158 T14065 T14064 arg1Of patients,asthma
R12159 T14067 T14066 arg1Of vitro,in
R12160 T14068 T14054 arg2Of and,suppress
R12161 T14070 T14069 arg1Of vivo,in
R12162 T14072 T14071 arg2Of 40,[
R12163 T14073 T14071 arg3Of ],[
R12164 T14074 T14068 arg2Of –,and
R12165 T14074 T14070 arg1Of –,vivo
R12166 T14074 T14071 arg1Of –,[
R12167 T14074 T14075 arg1Of –,[
R12168 T14076 T14075 arg2Of 42,[
R12169 T14077 T14075 arg3Of ],[
R12170 T14079 T14078 arg2Of summary,In
R12171 T14082 T14081 arg1Of data,our
R12172 T14082 T14083 arg1Of data,provide
R12173 T14083 T14078 arg1Of provide,In
R12174 T14083 T14080 arg1Of provide,","
R12175 T14083 T14096 arg1Of provide,through
R12176 T14083 T14116 arg1Of provide,by
R12177 T14084 T14083 arg2Of evidence,provide
R12178 T14084 T14085 arg1Of evidence,for
R12179 T14088 T14089 arg1Of action,of
R12180 T14090 T14089 arg2Of corticosteroids,of
R12181 T14090 T14091 arg1Of corticosteroids,:
R12182 T14092 T14085 arg2Of suppression,for
R12183 T14092 T14086 arg1Of suppression,a
R12184 T14092 T14087 arg1Of suppression,novel
R12185 T14092 T14088 arg1Of suppression,action
R12186 T14092 T14093 arg1Of suppression,of
R12187 T14095 T14093 arg2Of inflammation,of
R12188 T14095 T14094 arg1Of inflammation,allergic
R12189 T14096 T14115 arg1Of through,and
R12190 T14100 T14096 arg2Of effect,through
R12191 T14100 T14097 arg1Of effect,a
R12192 T14100 T14098 arg1Of effect,rapid
R12193 T14100 T14099 arg1Of effect,inhibitory
R12194 T14100 T14101 arg1Of effect,on
R12195 T14100 T14105 arg1Of effect,by
R12196 T14104 T14101 arg2Of translocation,on
R12197 T14104 T14102 arg1Of translocation,GATA-3
R12198 T14104 T14103 arg1Of translocation,nuclear
R12199 T14107 T14105 arg2Of binding,by
R12200 T14107 T14106 arg1Of binding,preferential
R12201 T14107 T14108 arg1Of binding,to
R12202 T14114 T14108 arg2Of importin-α,to
R12203 T14114 T14109 arg1Of importin-α,the
R12204 T14114 T14110 arg1Of importin-α,shared
R12205 T14114 T14111 arg1Of importin-α,nuclear
R12206 T14114 T14112 arg1Of importin-α,import
R12207 T14114 T14113 arg1Of importin-α,protein
R12208 T14116 T14115 arg2Of by,and
R12209 T14119 T14116 arg2Of mechanism,by
R12210 T14119 T14117 arg1Of mechanism,a
R12211 T14119 T14118 arg1Of mechanism,second
R12212 T14119 T14120 arg1Of mechanism,involving
R12213 T14122 T14120 arg2Of synthesis,involving
R12214 T14122 T14121 arg2Of synthesis,increased
R12215 T14122 T14123 arg1Of synthesis,of
R12216 T14122 T14125 arg1Of synthesis,","
R12217 T14122 T14126 arg1Of synthesis,which
R12218 T14122 T14127 arg1Of synthesis,inhibits
R12219 T14124 T14123 arg2Of MKP-1,of
R12220 T14127 T14130 arg1Of inhibits,","
R12221 T14127 T14132 modOf inhibits,preventing
R12222 T14129 T14127 arg2Of MAPK,inhibits
R12223 T14129 T14128 arg1Of MAPK,p38
R12224 T14132 T14131 arg1Of preventing,thus
R12225 T14134 T14132 arg2Of phosphorylation,preventing
R12226 T14134 T14133 arg1Of phosphorylation,the
R12227 T14134 T14135 arg1Of phosphorylation,of
R12228 T14134 T14137 arg1Of phosphorylation,that
R12229 T14134 T14138 arg1Of phosphorylation,is
R12230 T14134 T14139 arg1Of phosphorylation,necessary
R12231 T14136 T14135 arg2Of GATA-3,of
R12232 T14139 T14138 arg2Of necessary,is
R12233 T14139 T14140 arg1Of necessary,for
R12234 T14142 T14140 arg2Of translocation,for
R12235 T14142 T14141 arg1Of translocation,nuclear
R12236 T14142 T14143 arg1Of translocation,of
R12237 T14144 T14143 arg2Of GATA-3,of
R12238 T14147 T14145 arg1Of mechanisms,These
R12239 T14147 T14146 arg1Of mechanisms,two
R12240 T14147 T14148 arg1Of mechanisms,are
R12241 T14147 T14149 arg1Of mechanisms,likely
R12242 T14147 T14151 arg1Of mechanisms,be
R12243 T14147 T14152 arg1Of mechanisms,synergistic
R12244 T14147 T14154 arg1Of mechanisms,accounting
R12245 T14148 T14153 arg1Of are,","
R12246 T14148 T14154 modOf are,accounting
R12247 T14149 T14148 arg2Of likely,are
R12248 T14151 T14149 arg2Of be,likely
R12249 T14151 T14150 arg1Of be,to
R12250 T14152 T14151 arg2Of synergistic,be
R12251 T14154 T14155 arg1Of accounting,for
R12252 T14157 T14158 arg1Of rapid,and
R12253 T14159 T14158 arg2Of potent,and
R12254 T14160 T14155 arg2Of effect,for
R12255 T14160 T14156 arg1Of effect,the
R12256 T14160 T14157 arg1Of effect,rapid
R12257 T14160 T14159 arg1Of effect,potent
R12258 T14160 T14161 arg1Of effect,of
R12259 T14160 T14163 arg1Of effect,on
R12260 T14162 T14161 arg2Of corticosteroids,of
R12261 T14165 T14163 arg2Of inflammation,on
R12262 T14165 T14164 arg1Of inflammation,allergic
R12263 T14166 T14167 arg1Of This,is
R12264 T14166 T14168 arg2Of This,exemplified
R12265 T14168 T14167 arg2Of exemplified,is
R12266 T14173 T14168 arg1Of effect,exemplified
R12267 T14173 T14169 arg2Of effect,by
R12268 T14173 T14170 arg1Of effect,the
R12269 T14173 T14171 arg1Of effect,rapid
R12270 T14173 T14172 arg1Of effect,inhibitory
R12271 T14173 T14174 arg1Of effect,of
R12272 T14173 T14177 arg1Of effect,on
R12273 T14173 T14182 arg1Of effect,after
R12274 T14176 T14174 arg2Of corticosteroids,of
R12275 T14176 T14175 arg1Of corticosteroids,topical
R12276 T14181 T14177 arg2Of release,on
R12277 T14181 T14178 arg1Of release,nasal
R12278 T14181 T14179 arg1Of release,Th2
R12279 T14181 T14180 arg1Of release,cytokine
R12280 T14184 T14182 arg2Of provocation,after
R12281 T14184 T14183 arg1Of provocation,allergen
R12282 T14184 T14185 arg1Of provocation,in
R12283 T14186 T14185 arg2Of individuals,in
R12284 T14186 T14187 arg1Of individuals,with
R12285 T14190 T14187 arg2Of rhinitis,with
R12286 T14190 T14188 arg1Of rhinitis,seasonal
R12287 T14190 T14189 arg1Of rhinitis,allergic
R12288 T14190 T14191 arg1Of rhinitis,(
R12289 T14190 T14195 arg1Of rhinitis,[
R12290 T14193 T14191 arg2Of fever,(
R12291 T14193 T14192 arg1Of fever,hay
R12292 T14194 T14191 arg3Of ),(
R12293 T14196 T14195 arg2Of 43,[
R12294 T14197 T14195 arg3Of ],[
R12295 T14198 T14199 arg1Of Prevention,of
R12296 T14198 T14204 arg1Of Prevention,may
R12297 T14198 T14205 arg1Of Prevention,provide
R12298 T14201 T14199 arg2Of interaction,of
R12299 T14201 T14200 arg1Of interaction,phospho-GATA-3
R12300 T14201 T14202 arg1Of interaction,with
R12301 T14203 T14202 arg2Of importin-α,with
R12302 T14205 T14204 arg2Of provide,may
R12303 T14208 T14205 arg2Of approach,provide
R12304 T14208 T14206 arg1Of approach,a
R12305 T14208 T14207 arg1Of approach,new
R12306 T14208 T14209 arg1Of approach,for
R12307 T14211 T14209 arg2Of development,for
R12308 T14211 T14210 arg1Of development,the
R12309 T14211 T14212 arg1Of development,of
R12310 T14211 T14215 arg1Of development,for
R12311 T14214 T14212 arg2Of therapies,of
R12312 T14214 T14213 arg1Of therapies,novel
R12313 T14217 T14215 arg2Of treatment,for
R12314 T14217 T14216 arg1Of treatment,the
R12315 T14217 T14218 arg1Of treatment,of
R12316 T14220 T14218 arg2Of diseases,of
R12317 T14220 T14219 arg1Of diseases,allergic

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T14221 641-645 Anaphor denotes that
T14222 615-630 Antecedent denotes phosphorylation
T14223 1126-1137 Anaphor denotes these genes
T14224 1030-1034 Antecedent denotes IL-4
T14225 1035-1039 Antecedent denotes IL-5
R12318 T14221 T14222 boundBy that,phosphorylation
R12319 T14223 T14224 boundBy these genes,IL-4
R12320 T14223 T14225 boundBy these genes,IL-5

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T14309 11-15 RB denotes Here
T14310 16-18 PRP denotes we
T14311 19-23 VBP denotes have
T14312 24-36 VBN denotes demonstrated
T14313 36-37 , denotes ,
T14314 38-40 TO denotes to
T14315 41-44 PRP$ denotes our
T14316 45-54 NN denotes knowledge
T14317 55-58 IN denotes for
T14318 59-62 DT denotes the
T14319 63-68 JJ denotes first
T14320 69-73 NN denotes time
T14321 73-74 , denotes ,
T14322 75-79 IN denotes that
T14323 80-95 NNS denotes corticosteroids
T14324 96-99 MD denotes may
T14325 100-107 VB denotes inhibit
T14326 108-114 JJ denotes GATA-3
T14327 115-123 NN denotes function
T14328 124-127 CC denotes and
T14329 128-137 RB denotes therefore
T14330 138-141 DT denotes the
T14331 142-155 NN denotes transcription
T14332 156-158 IN denotes of
T14333 159-162 JJ denotes Th2
T14334 163-168 NNS denotes genes
T14335 169-172 IN denotes via
T14336 173-176 CD denotes two
T14337 177-185 JJ denotes distinct
T14338 186-189 CC denotes but
T14339 190-201 VBG denotes interacting
T14340 202-211 JJ denotes molecular
T14341 212-222 NNS denotes mechanisms
T14342 222-223 . denotes .
T14343 224-231 RB denotes Firstly
T14344 231-232 , denotes ,
T14345 233-257 JJ denotes corticosteroid-activated
T14346 258-260 NNP denotes GR
T14347 261-268 VBZ denotes appears
T14348 269-271 TO denotes to
T14349 272-279 VB denotes compete
T14350 280-284 IN denotes with
T14351 285-294 VBN denotes activated
T14352 295-301 NNP denotes GATA-3
T14353 302-305 IN denotes for
T14354 306-313 JJ denotes nuclear
T14355 314-320 NN denotes import
T14356 321-324 IN denotes via
T14357 325-335 JJ denotes importin-α
T14358 335-336 , denotes ,
T14359 337-342 WDT denotes which
T14360 343-345 VBZ denotes is
T14361 346-354 VBN denotes required
T14362 355-358 IN denotes for
T14363 359-362 DT denotes the
T14364 363-370 JJ denotes nuclear
T14365 371-380 NN denotes transport
T14366 381-383 IN denotes of
T14367 384-388 DT denotes both
T14368 389-395 NNP denotes GATA-3
T14369 396-399 CC denotes and
T14370 400-402 NNP denotes GR
T14371 402-403 . denotes .
T14372 404-412 RB denotes Secondly
T14373 412-413 , denotes ,
T14374 414-429 NNS denotes corticosteroids
T14375 430-432 IN denotes at
T14376 433-439 JJR denotes higher
T14377 440-454 NNS denotes concentrations
T14378 455-463 VB denotes increase
T14379 464-467 DT denotes the
T14380 468-478 NN denotes expression
T14381 479-481 IN denotes of
T14382 482-487 NNP denotes MKP-1
T14383 487-488 , denotes ,
T14384 489-490 DT denotes a
T14385 491-497 JJ denotes potent
T14386 498-507 NN denotes inhibitor
T14387 508-510 IN denotes of
T14388 511-514 CD denotes p38
T14389 515-519 NNP denotes MAPK
T14390 520-528 NN denotes activity
T14391 529-532 CC denotes and
T14392 533-540 RB denotes thereby
T14393 541-548 VB denotes prevent
T14394 549-550 NNP denotes T
T14395 551-555 NN denotes cell
T14396 556-576 NN denotes receptor/co-receptor
T14397 577-587 NN denotes activation
T14398 588-590 IN denotes of
T14399 591-594 CD denotes p38
T14400 595-599 NNP denotes MAPK
T14401 600-602 TO denotes to
T14402 603-610 VB denotes prevent
T14403 611-614 DT denotes the
T14404 615-630 NN denotes phosphorylation
T14405 631-633 IN denotes of
T14406 634-640 NN denotes GATA-3
T14407 641-645 WDT denotes that
T14408 646-648 VBZ denotes is
T14409 649-658 JJ denotes necessary
T14410 659-662 IN denotes for
T14411 663-674 NN denotes interaction
T14412 675-679 IN denotes with
T14413 680-690 JJ denotes importin-α
T14414 691-694 CC denotes and
T14415 695-705 JJ denotes subsequent
T14416 706-713 JJ denotes nuclear
T14417 714-720 NN denotes import
T14418 720-721 . denotes .
T14419 722-724 PRP denotes We
T14420 725-729 VBP denotes have
T14421 730-740 RB denotes previously
T14422 741-746 VBN denotes shown
T14423 747-751 IN denotes that
T14424 752-765 NN denotes translocation
T14425 766-768 IN denotes of
T14426 769-775 NN denotes GATA-3
T14427 776-780 IN denotes from
T14428 781-784 DT denotes the
T14429 785-794 NN denotes cytoplasm
T14430 795-797 TO denotes to
T14431 798-801 DT denotes the
T14432 802-809 NN denotes nucleus
T14433 810-818 VBZ denotes involves
T14434 819-822 DT denotes the
T14435 823-830 JJ denotes nuclear
T14436 831-842 NN denotes transporter
T14437 843-850 NN denotes protein
T14438 851-861 NN denotes importin-α
T14439 861-862 , denotes ,
T14440 863-868 WDT denotes which
T14441 869-878 VBZ denotes interacts
T14442 879-883 IN denotes with
T14443 884-898 VBN denotes phosphorylated
T14444 899-905 NNP denotes GATA-3
T14445 906-907 NNP denotes [
T14446 907-909 CD denotes 12
T14447 909-910 NNP denotes ]
T14448 910-911 . denotes .
T14449 912-914 PRP denotes We
T14450 915-919 VBP denotes have
T14451 920-924 RB denotes also
T14452 925-935 RB denotes previously
T14453 936-944 VBN denotes reported
T14454 945-949 IN denotes that
T14455 950-956 JJ denotes GATA-3
T14456 957-966 NN denotes knockdown
T14457 967-972 VBG denotes using
T14458 973-978 NNP denotes siRNA
T14459 979-986 NNS denotes results
T14460 987-989 IN denotes in
T14461 990-1001 NN denotes suppression
T14462 1002-1004 IN denotes of
T14463 1005-1013 JJ denotes anti-CD3
T14464 1013-1014 NN denotes /
T14465 1014-1018 CD denotes CD28
T14466 1019-1029 VBD denotes stimulated
T14467 1030-1034 NN denotes IL-4
T14468 1034-1035 NN denotes /
T14469 1035-1039 NN denotes IL-5
T14470 1040-1044 NNP denotes mRNA
T14471 1045-1054 NN denotes induction
T14472 1054-1055 , denotes ,
T14473 1056-1060 RB denotes thus
T14474 1061-1072 VBG denotes implicating
T14475 1073-1075 DT denotes an
T14476 1076-1085 JJ denotes essential
T14477 1086-1090 NN denotes role
T14478 1091-1094 IN denotes for
T14479 1095-1101 NNP denotes GATA-3
T14480 1102-1104 IN denotes in
T14481 1105-1108 DT denotes the
T14482 1109-1122 NN denotes transcription
T14483 1123-1125 IN denotes of
T14484 1126-1131 DT denotes these
T14485 1132-1137 NNS denotes genes
T14486 1138-1139 NNP denotes [
T14487 1139-1141 CD denotes 12
T14488 1141-1142 NNP denotes ]
T14489 1142-1143 . denotes .
T14490 1144-1146 PRP denotes We
T14491 1147-1150 RB denotes now
T14492 1151-1158 VBP denotes confirm
T14493 1158-1159 , denotes ,
T14494 1160-1162 IN denotes in
T14495 1163-1168 JJ denotes human
T14496 1169-1170 NNP denotes T
T14497 1171-1176 NNS denotes cells
T14498 1176-1177 , denotes ,
T14499 1178-1182 IN denotes that
T14500 1183-1185 NNP denotes GR
T14501 1186-1190 RB denotes also
T14502 1191-1195 VBZ denotes uses
T14503 1196-1199 DT denotes the
T14504 1200-1204 JJ denotes same
T14505 1205-1212 JJ denotes nuclear
T14506 1213-1219 NN denotes import
T14507 1220-1229 NN denotes mechanism
T14508 1230-1232 IN denotes as
T14509 1233-1239 JJ denotes GATA-3
T14510 1240-1241 NNP denotes [
T14511 1241-1243 CD denotes 22
T14512 1243-1244 NNP denotes ]
T14513 1244-1245 . denotes .
T14514 1246-1248 PRP denotes We
T14515 1249-1258 RB denotes therefore
T14516 1259-1266 VBP denotes propose
T14517 1267-1271 IN denotes that
T14518 1272-1277 EX denotes there
T14519 1278-1280 VBZ denotes is
T14520 1281-1292 NN denotes competition
T14521 1293-1300 IN denotes between
T14522 1301-1317 JJ denotes ligand-activated
T14523 1318-1320 NNP denotes GR
T14524 1321-1324 CC denotes and
T14525 1325-1339 NNP denotes phospho-GATA-3
T14526 1340-1343 IN denotes for
T14527 1344-1351 JJ denotes nuclear
T14528 1352-1358 NN denotes import
T14529 1358-1359 . denotes .
T14530 1360-1371 RB denotes Furthermore
T14531 1371-1372 , denotes ,
T14532 1373-1375 PRP denotes we
T14533 1376-1380 VBP denotes have
T14534 1381-1386 VBN denotes shown
T14535 1387-1391 IN denotes that
T14536 1392-1397 EX denotes there
T14537 1398-1400 VBZ denotes is
T14538 1401-1413 JJ denotes preferential
T14539 1414-1421 JJ denotes binding
T14540 1422-1424 IN denotes of
T14541 1425-1435 JJ denotes importin-α
T14542 1436-1438 TO denotes to
T14543 1439-1448 VBN denotes activated
T14544 1449-1451 NNP denotes GR
T14545 1452-1456 IN denotes over
T14546 1457-1471 NNP denotes phospho-GATA-3
T14547 1471-1472 , denotes ,
T14548 1473-1475 RB denotes so
T14549 1476-1480 IN denotes that
T14550 1481-1496 NNS denotes corticosteroids
T14551 1497-1502 MD denotes would
T14552 1503-1517 RB denotes preferentially
T14553 1518-1524 VB denotes reduce
T14554 1525-1531 JJ denotes GATA-3
T14555 1532-1537 NN denotes entry
T14556 1538-1541 CC denotes and
T14557 1542-1546 RB denotes thus
T14558 1547-1554 RB denotes rapidly
T14559 1555-1561 VB denotes switch
T14560 1562-1565 RP denotes off
T14561 1566-1569 CD denotes Th2
T14562 1570-1574 NN denotes gene
T14563 1575-1588 NN denotes transcription
T14564 1589-1596 IN denotes without
T14565 1597-1600 DT denotes any
T14566 1601-1605 NN denotes need
T14567 1606-1609 IN denotes for
T14568 1610-1613 DT denotes any
T14569 1614-1626 JJ denotes intermediate
T14570 1627-1632 NNS denotes steps
T14571 1632-1633 . denotes .
T14572 1634-1645 RB denotes Furthermore
T14573 1645-1646 , denotes ,
T14574 1647-1652 EX denotes there
T14575 1653-1656 VBD denotes was
T14576 1657-1661 DT denotes some
T14577 1662-1668 NN denotes degree
T14578 1669-1671 IN denotes of
T14579 1672-1683 NN denotes specificity
T14580 1684-1687 IN denotes for
T14581 1688-1694 NNP denotes GATA-3
T14582 1694-1695 , denotes ,
T14583 1696-1698 IN denotes as
T14584 1699-1706 JJ denotes nuclear
T14585 1707-1720 NN denotes translocation
T14586 1721-1723 IN denotes of
T14587 1724-1727 DT denotes the
T14588 1728-1731 CD denotes p65
T14589 1732-1739 NN denotes subunit
T14590 1740-1742 IN denotes of
T14591 1743-1748 NN denotes NF-κB
T14592 1749-1752 VBD denotes was
T14593 1753-1756 RB denotes not
T14594 1757-1765 VBN denotes affected
T14595 1766-1768 IN denotes by
T14596 1769-1783 JJ denotes corticosteroid
T14597 1784-1792 NN denotes exposure
T14598 1792-1793 . denotes .
T14599 1794-1796 PRP denotes We
T14600 1797-1803 VBD denotes tested
T14601 1804-1808 DT denotes some
T14602 1809-1820 JJ denotes alternative
T14603 1821-1833 NNS denotes explanations
T14604 1834-1837 IN denotes for
T14605 1838-1842 DT denotes this
T14606 1843-1849 NN denotes effect
T14607 1850-1852 IN denotes of
T14608 1853-1855 NNP denotes FP
T14609 1856-1858 IN denotes on
T14610 1859-1865 NNP denotes GATA-3
T14611 1866-1873 JJ denotes nuclear
T14612 1874-1883 NN denotes exclusion
T14613 1884-1887 CC denotes and
T14614 1888-1894 VBD denotes failed
T14615 1895-1897 TO denotes to
T14616 1898-1902 VB denotes show
T14617 1903-1907 IN denotes that
T14618 1908-1910 NNP denotes FP
T14619 1911-1917 CC denotes either
T14620 1918-1926 VBZ denotes enhances
T14621 1927-1933 JJ denotes GATA-3
T14622 1934-1941 JJ denotes nuclear
T14623 1942-1948 NN denotes export
T14624 1949-1957 RB denotes directly
T14625 1958-1960 CC denotes or
T14626 1961-1968 VBZ denotes induces
T14627 1969-1975 JJ denotes GATA-3
T14628 1976-1987 NN denotes degradation
T14629 1987-1988 . denotes .
T14630 1989-1992 DT denotes The
T14631 1993-2001 NN denotes evidence
T14632 2002-2006 IN denotes from
T14633 2007-2010 DT denotes the
T14634 2011-2013 IN denotes in
T14635 2014-2019 NN denotes vitro
T14636 2020-2031 NN denotes competition
T14637 2032-2038 VBZ denotes assays
T14638 2039-2043 VBZ denotes does
T14639 2043-2044 , denotes ,
T14640 2045-2052 RB denotes however
T14641 2052-2053 , denotes ,
T14642 2054-2061 VBP denotes suggest
T14643 2062-2066 IN denotes that
T14644 2067-2075 JJ denotes purified
T14645 2076-2085 VBN denotes activated
T14646 2086-2088 NNP denotes GR
T14647 2089-2092 MD denotes can
T14648 2093-2100 RB denotes clearly
T14649 2101-2110 VB denotes attenuate
T14650 2111-2119 VBN denotes purified
T14651 2120-2134 JJ denotes phospho-GATA-3
T14652 2135-2145 JJ denotes importin-α
T14653 2146-2157 NN denotes association
T14654 2158-2161 CC denotes and
T14655 2162-2166 IN denotes that
T14656 2167-2170 DT denotes the
T14657 2171-2179 NN denotes converse
T14658 2180-2184 VBZ denotes does
T14659 2185-2188 RB denotes not
T14660 2189-2194 VB denotes occur
T14661 2194-2195 . denotes .
T14662 2196-2207 RB denotes Furthermore
T14663 2207-2208 , denotes ,
T14664 2209-2211 PRP denotes we
T14665 2212-2216 VBP denotes have
T14666 2217-2222 VBN denotes shown
T14667 2223-2227 IN denotes that
T14668 2228-2232 RB denotes only
T14669 2233-2247 JJ denotes phospho-GATA-3
T14670 2248-2251 MD denotes can
T14671 2252-2261 VB denotes associate
T14672 2262-2266 IN denotes with
T14673 2267-2277 JJ denotes importin-α
T14674 2277-2278 . denotes .
T14675 2279-2283 DT denotes This
T14676 2284-2293 NN denotes mechanism
T14677 2294-2296 VBZ denotes is
T14678 2297-2306 JJ denotes sensitive
T14679 2307-2309 TO denotes to
T14680 2310-2314 RB denotes very
T14681 2315-2318 JJ denotes low
T14682 2319-2333 NNS denotes concentrations
T14683 2334-2336 IN denotes of
T14684 2337-2351 JJ denotes corticosteroid
T14685 2352-2355 CC denotes and
T14686 2356-2361 MD denotes would
T14687 2362-2364 VB denotes be
T14688 2365-2370 JJ denotes rapid
T14689 2371-2373 IN denotes in
T14690 2374-2379 NN denotes onset
T14691 2380-2382 IN denotes as
T14692 2383-2385 DT denotes no
T14693 2386-2393 NNS denotes changes
T14694 2394-2396 IN denotes in
T14695 2397-2404 NN denotes protein
T14696 2405-2414 NN denotes synthesis
T14697 2415-2418 VBP denotes are
T14698 2419-2427 VBN denotes required
T14699 2427-2428 . denotes .
T14700 2429-2433 DT denotes This
T14701 2434-2439 JJ denotes acute
T14702 2440-2449 NN denotes mechanism
T14703 2450-2453 MD denotes may
T14704 2454-2458 RB denotes also
T14705 2459-2469 VB denotes contribute
T14706 2470-2472 TO denotes to
T14707 2473-2476 DT denotes the
T14708 2477-2486 NN denotes reduction
T14709 2487-2489 IN denotes in
T14710 2490-2496 JJ denotes GATA-3
T14711 2497-2504 JJ denotes nuclear
T14712 2505-2511 NN denotes import
T14713 2512-2515 CC denotes and
T14714 2516-2519 MD denotes may
T14715 2520-2524 VB denotes play
T14716 2525-2526 DT denotes a
T14717 2527-2532 JJ denotes major
T14718 2533-2537 NN denotes role
T14719 2538-2540 IN denotes at
T14720 2541-2544 JJ denotes low
T14721 2545-2559 JJ denotes corticosteroid
T14722 2560-2574 NNS denotes concentrations
T14723 2575-2581 CC denotes and/or
T14724 2582-2584 IN denotes at
T14725 2585-2590 JJ denotes early
T14726 2591-2595 NN denotes time
T14727 2596-2602 NNS denotes points
T14728 2603-2608 RB denotes prior
T14729 2609-2611 TO denotes to
T14730 2612-2617 NNP denotes MKP-1
T14731 2618-2627 NN denotes induction
T14732 2627-2628 . denotes .
T14733 2629-2644 NNS denotes Corticosteroids
T14734 2645-2648 MD denotes can
T14735 2649-2657 VB denotes modulate
T14736 2658-2661 CD denotes p38
T14737 2662-2666 NNP denotes MAPK
T14738 2667-2675 NN denotes activity
T14739 2676-2683 IN denotes through
T14740 2684-2687 DT denotes the
T14741 2688-2697 NN denotes induction
T14742 2698-2700 IN denotes of
T14743 2701-2706 NNP denotes MKP-1
T14744 2706-2707 , denotes ,
T14745 2708-2709 DT denotes a
T14746 2710-2716 JJ denotes potent
T14747 2717-2727 JJ denotes endogenous
T14748 2728-2737 NN denotes inhibitor
T14749 2738-2740 IN denotes of
T14750 2741-2745 NNP denotes MAPK
T14751 2746-2754 NN denotes function
T14752 2755-2756 NNP denotes [
T14753 2756-2758 CD denotes 38
T14754 2758-2759 NNP denotes ]
T14755 2759-2760 , denotes ,
T14756 2760-2761 NNP denotes [
T14757 2761-2763 CD denotes 39
T14758 2763-2764 NNP denotes ]
T14759 2764-2765 . denotes .
T14760 2766-2768 PRP denotes We
T14761 2769-2775 VBP denotes report
T14762 2776-2780 RB denotes here
T14763 2781-2782 DT denotes a
T14764 2783-2788 JJ denotes rapid
T14765 2789-2798 NN denotes induction
T14766 2799-2801 IN denotes of
T14767 2802-2807 NNP denotes MKP-1
T14768 2808-2812 NNP denotes mRNA
T14769 2813-2822 VBG denotes following
T14770 2823-2834 NN denotes stimulation
T14771 2835-2837 IN denotes of
T14772 2838-2843 NNS denotes cells
T14773 2844-2848 IN denotes with
T14774 2849-2859 RB denotes relatively
T14775 2860-2864 JJ denotes high
T14776 2865-2879 NNS denotes concentrations
T14777 2880-2882 IN denotes of
T14778 2883-2885 NNP denotes FP
T14779 2885-2886 . denotes .
T14780 2887-2889 PRP denotes We
T14781 2890-2901 VBP denotes hypothesize
T14782 2902-2906 IN denotes that
T14783 2907-2911 DT denotes this
T14784 2912-2917 JJ denotes rapid
T14785 2918-2927 NN denotes induction
T14786 2928-2930 IN denotes of
T14787 2931-2936 NN denotes MKP-1
T14788 2937-2940 MD denotes can
T14789 2941-2947 VB denotes reduce
T14790 2948-2954 JJ denotes GATA-3
T14791 2955-2962 JJ denotes nuclear
T14792 2963-2969 NN denotes import
T14793 2970-2972 IN denotes by
T14794 2973-2984 VBG denotes attenuating
T14795 2985-2988 CD denotes p38
T14796 2989-2993 NNP denotes MAPK
T14797 2994-3002 NN denotes activity
T14798 3003-3006 CC denotes and
T14799 3007-3017 JJ denotes subsequent
T14800 3018-3024 NN denotes GATA-3
T14801 3025-3040 NN denotes phosphorylation
T14802 3040-3041 , denotes ,
T14803 3042-3046 RB denotes thus
T14804 3047-3057 VBG denotes preventing
T14805 3058-3065 JJ denotes nuclear
T14806 3066-3079 NN denotes translocation
T14807 3079-3080 . denotes .
T14808 3081-3084 DT denotes The
T14809 3085-3093 NN denotes location
T14810 3094-3096 IN denotes of
T14811 3097-3100 DT denotes the
T14812 3101-3107 NN denotes serine
T14813 3108-3115 NN denotes residue
T14814 3115-3116 -LRB- denotes (
T14815 3116-3117 PRP denotes s
T14816 3117-3118 -RRB- denotes )
T14817 3119-3121 IN denotes of
T14818 3122-3128 NN denotes GATA-3
T14819 3129-3133 WDT denotes that
T14820 3134-3137 VBP denotes are
T14821 3138-3152 VBN denotes phosphorylated
T14822 3153-3155 IN denotes by
T14823 3156-3159 CD denotes p38
T14824 3160-3164 NNP denotes MAPK
T14825 3165-3168 VBP denotes are
T14826 3169-3178 RB denotes currently
T14827 3179-3186 JJ denotes unknown
T14828 3186-3187 , denotes ,
T14829 3188-3191 CC denotes but
T14830 3192-3193 DT denotes a
T14831 3194-3208 NNS denotes bioinformatics
T14832 3209-3215 NN denotes search
T14833 3216-3217 -LRB- denotes (
T14834 3217-3222 NNP denotes Motif
T14835 3223-3230 NNP denotes Scanner
T14836 3230-3231 , denotes ,
T14837 3232-3275 NNP denotes http://scansite.mit.edu/motifscan_seq.phtml
T14838 3275-3276 -RRB- denotes )
T14839 3277-3286 VBZ denotes indicates
T14840 3287-3289 IN denotes at
T14841 3290-3295 JJS denotes least
T14842 3296-3301 CD denotes three
T14843 3302-3311 JJ denotes potential
T14844 3312-3315 CD denotes p38
T14845 3316-3330 JJ denotes MAPK-sensitive
T14846 3331-3337 NN denotes serine
T14847 3338-3346 NNS denotes residues
T14848 3346-3347 . denotes .
T14849 3348-3350 IN denotes As
T14850 3351-3360 VBN denotes predicted
T14851 3361-3365 IN denotes from
T14852 3366-3371 DT denotes these
T14853 3372-3374 IN denotes in
T14854 3375-3380 NN denotes vitro
T14855 3381-3385 NNS denotes data
T14856 3385-3386 , denotes ,
T14857 3387-3397 NN denotes impairment
T14858 3398-3400 IN denotes of
T14859 3401-3407 JJ denotes GATA-3
T14860 3408-3415 JJ denotes nuclear
T14861 3416-3422 NN denotes import
T14862 3423-3425 IN denotes by
T14863 3426-3428 NNP denotes FP
T14864 3429-3432 MD denotes may
T14865 3432-3433 , denotes ,
T14866 3434-3436 IN denotes at
T14867 3437-3442 JJS denotes least
T14868 3443-3445 IN denotes in
T14869 3446-3450 NN denotes part
T14870 3450-3451 , denotes ,
T14871 3452-3460 VBP denotes underlie
T14872 3461-3464 DT denotes the
T14873 3465-3473 NN denotes efficacy
T14874 3474-3476 IN denotes of
T14875 3477-3492 NNS denotes corticosteroids
T14876 3493-3495 IN denotes in
T14877 3496-3507 VBG denotes suppressing
T14878 3508-3516 JJ denotes allergic
T14879 3517-3529 NN denotes inflammation
T14880 3529-3530 . denotes .
T14881 3531-3539 IN denotes Although
T14882 3540-3542 PRP denotes we
T14883 3543-3546 VBD denotes did
T14884 3547-3550 RB denotes not
T14885 3551-3557 VB denotes assess
T14886 3558-3561 DT denotes the
T14887 3562-3567 JJ denotes acute
T14888 3568-3578 JJ denotes inhibitory
T14889 3579-3585 NN denotes effect
T14890 3586-3588 IN denotes of
T14891 3589-3591 NNP denotes FP
T14892 3592-3594 IN denotes on
T14893 3595-3598 DT denotes the
T14894 3599-3609 NN denotes expression
T14895 3610-3612 IN denotes of
T14896 3613-3617 NN denotes IL-4
T14897 3618-3622 NNP denotes mRNA
T14898 3623-3625 IN denotes in
T14899 3626-3630 NN denotes vivo
T14900 3630-3631 , denotes ,
T14901 3632-3633 DT denotes a
T14902 3634-3640 JJ denotes single
T14903 3641-3651 NN denotes inhalation
T14904 3652-3654 IN denotes of
T14905 3655-3657 NNP denotes FP
T14906 3658-3659 -LRB- denotes (
T14907 3659-3662 CD denotes 500
T14908 3663-3665 NN denotes µg
T14909 3665-3666 -RRB- denotes )
T14910 3667-3670 MD denotes may
T14911 3671-3675 VB denotes have
T14912 3676-3686 JJ denotes comparable
T14913 3687-3694 NNS denotes effects
T14914 3694-3695 , denotes ,
T14915 3696-3698 IN denotes as
T14916 3699-3701 PRP denotes it
T14917 3702-3710 VBZ denotes provides
T14918 3711-3717 NN denotes plasma
T14919 3718-3724 NNS denotes levels
T14920 3725-3731 IN denotes within
T14921 3732-3733 DT denotes a
T14922 3734-3742 JJ denotes relevant
T14923 3743-3748 NN denotes range
T14924 3749-3751 IN denotes of
T14925 3752-3766 NNS denotes concentrations
T14926 3767-3771 VBN denotes used
T14927 3772-3774 TO denotes to
T14928 3775-3783 VB denotes suppress
T14929 3784-3788 NN denotes IL-4
T14930 3789-3802 NN denotes transcription
T14931 3803-3805 IN denotes in
T14932 3806-3809 PRP$ denotes our
T14933 3810-3812 IN denotes in
T14934 3813-3818 NN denotes vitro
T14935 3819-3825 NN denotes system
T14936 3826-3827 NNP denotes [
T14937 3827-3829 CD denotes 37
T14938 3829-3830 NNP denotes ]
T14939 3830-3831 . denotes .
T14940 3832-3833 DT denotes A
T14941 3834-3839 JJR denotes lower
T14942 3840-3844 NN denotes dose
T14943 3845-3847 IN denotes of
T14944 3848-3855 JJ denotes inhaled
T14945 3856-3858 NNP denotes FP
T14946 3859-3860 -LRB- denotes (
T14947 3860-3863 CD denotes 100
T14948 3864-3866 NN denotes µg
T14949 3866-3867 -RRB- denotes )
T14950 3868-3871 VBD denotes was
T14951 3872-3875 RB denotes not
T14952 3876-3885 JJ denotes effective
T14953 3885-3886 , denotes ,
T14954 3887-3890 CC denotes but
T14955 3891-3897 NN denotes plasma
T14956 3898-3912 NNS denotes concentrations
T14957 3913-3916 MD denotes may
T14958 3917-3919 VB denotes be
T14959 3920-3925 IN denotes below
T14960 3926-3931 DT denotes those
T14961 3932-3940 VBN denotes required
T14962 3941-3944 IN denotes for
T14963 3945-3951 JJ denotes GATA-3
T14964 3952-3962 NN denotes inhibition
T14965 3962-3963 . denotes .
T14966 3964-3971 RB denotes However
T14967 3971-3972 , denotes ,
T14968 3973-3975 PRP denotes it
T14969 3976-3978 VBZ denotes is
T14970 3979-3985 JJ denotes likely
T14971 3986-3990 IN denotes that
T14972 3991-3994 DT denotes the
T14973 3995-4001 JJR denotes higher
T14974 4002-4016 NNS denotes concentrations
T14975 4017-4019 IN denotes of
T14976 4020-4022 NNP denotes FP
T14977 4023-4025 IN denotes in
T14978 4026-4029 DT denotes the
T14979 4030-4037 NNS denotes airways
T14980 4038-4043 IN denotes after
T14981 4044-4051 JJ denotes inhaled
T14982 4052-4066 NN denotes administration
T14983 4067-4072 MD denotes would
T14984 4073-4075 VB denotes be
T14985 4076-4085 JJ denotes effective
T14986 4086-4088 IN denotes in
T14987 4089-4099 VBG denotes inhibiting
T14988 4100-4106 NN denotes GATA-3
T14989 4107-4109 IN denotes in
T14990 4110-4116 NN denotes airway
T14991 4117-4118 NNP denotes T
T14992 4119-4124 NNS denotes cells
T14993 4125-4127 IN denotes of
T14994 4128-4134 NN denotes asthma
T14995 4135-4143 NNS denotes patients
T14996 4143-4144 . denotes .
T14997 4145-4148 DT denotes The
T14998 4149-4154 NN denotes study
T14999 4155-4157 IN denotes of
T15000 4158-4163 NNS denotes PBMCs
T15001 4164-4168 IN denotes from
T15002 4169-4175 NN denotes asthma
T15003 4176-4184 NNS denotes patients
T15004 4185-4192 VBN denotes treated
T15005 4193-4197 IN denotes with
T15006 4198-4205 JJ denotes inhaled
T15007 4206-4220 JJ denotes corticosteroid
T15008 4221-4228 NN denotes therapy
T15009 4229-4236 RB denotes clearly
T15010 4237-4249 VBZ denotes demonstrates
T15011 4250-4254 IN denotes that
T15012 4255-4260 DT denotes these
T15013 4261-4270 JJ denotes molecular
T15014 4271-4281 NNS denotes mechanisms
T15015 4282-4285 VBP denotes are
T15016 4286-4292 JJ denotes likely
T15017 4293-4295 TO denotes to
T15018 4296-4300 RB denotes also
T15019 4301-4306 VB denotes occur
T15020 4307-4309 IN denotes in
T15021 4310-4318 NNS denotes patients
T15022 4319-4321 IN denotes at
T15023 4322-4333 JJ denotes therapeutic
T15024 4334-4339 NNS denotes doses
T15025 4340-4342 IN denotes of
T15026 4343-4350 JJ denotes inhaled
T15027 4351-4366 NNS denotes corticosteroids
T15028 4366-4367 . denotes .
T15029 4368-4370 IN denotes In
T15030 4371-4379 NN denotes addition
T15031 4379-4380 , denotes ,
T15032 4381-4389 JJ denotes previous
T15033 4390-4397 NNS denotes studies
T15034 4398-4402 VBP denotes have
T15035 4403-4408 VBN denotes shown
T15036 4409-4413 IN denotes that
T15037 4414-4429 NNS denotes corticosteroids
T15038 4430-4433 MD denotes can
T15039 4434-4442 VB denotes suppress
T15040 4443-4447 NN denotes IL-4
T15041 4448-4451 CC denotes and
T15042 4452-4456 NN denotes IL-5
T15043 4457-4464 NN denotes release
T15044 4465-4469 IN denotes from
T15045 4470-4480 JJ denotes peripheral
T15046 4481-4486 NN denotes blood
T15047 4487-4492 NNS denotes cells
T15048 4493-4495 IN denotes of
T15049 4496-4502 NN denotes asthma
T15050 4503-4511 NNS denotes patients
T15051 4512-4514 IN denotes in
T15052 4515-4520 NN denotes vitro
T15053 4521-4524 CC denotes and
T15054 4525-4527 IN denotes in
T15055 4528-4532 NN denotes vivo
T15056 4533-4534 NNP denotes [
T15057 4534-4536 CD denotes 40
T15058 4536-4537 NNP denotes ]
T15059 4538-4539 NNP denotes [
T15060 4539-4541 CD denotes 42
T15061 4541-4542 NNP denotes ]
T15062 4542-4543 . denotes .
T15063 4544-4546 IN denotes In
T15064 4547-4554 NN denotes summary
T15065 4554-4555 , denotes ,
T15066 4556-4559 PRP$ denotes our
T15067 4560-4564 NNS denotes data
T15068 4565-4572 VBP denotes provide
T15069 4573-4581 NN denotes evidence
T15070 4582-4585 IN denotes for
T15071 4586-4587 DT denotes a
T15072 4588-4593 NN denotes novel
T15073 4594-4600 NN denotes action
T15074 4601-4603 IN denotes of
T15075 4604-4619 NNS denotes corticosteroids
T15076 4619-4620 : denotes :
T15077 4621-4632 NN denotes suppression
T15078 4633-4635 IN denotes of
T15079 4636-4644 JJ denotes allergic
T15080 4645-4657 NN denotes inflammation
T15081 4658-4665 IN denotes through
T15082 4666-4667 DT denotes a
T15083 4668-4673 JJ denotes rapid
T15084 4674-4684 JJ denotes inhibitory
T15085 4685-4691 NN denotes effect
T15086 4692-4694 IN denotes on
T15087 4695-4701 JJ denotes GATA-3
T15088 4702-4709 JJ denotes nuclear
T15089 4710-4723 NN denotes translocation
T15090 4724-4726 IN denotes by
T15091 4727-4739 JJ denotes preferential
T15092 4740-4747 JJ denotes binding
T15093 4748-4750 TO denotes to
T15094 4751-4754 DT denotes the
T15095 4755-4761 VBN denotes shared
T15096 4762-4769 JJ denotes nuclear
T15097 4770-4776 NN denotes import
T15098 4777-4784 NN denotes protein
T15099 4785-4795 NN denotes importin-α
T15100 4796-4799 CC denotes and
T15101 4800-4802 IN denotes by
T15102 4803-4804 DT denotes a
T15103 4805-4811 JJ denotes second
T15104 4812-4821 NN denotes mechanism
T15105 4822-4831 VBG denotes involving
T15106 4832-4841 VBN denotes increased
T15107 4842-4851 NN denotes synthesis
T15108 4852-4854 IN denotes of
T15109 4855-4860 NNP denotes MKP-1
T15110 4860-4861 , denotes ,
T15111 4862-4867 WDT denotes which
T15112 4868-4876 VBZ denotes inhibits
T15113 4877-4880 CD denotes p38
T15114 4881-4885 NNP denotes MAPK
T15115 4885-4886 , denotes ,
T15116 4887-4891 RB denotes thus
T15117 4892-4902 VBG denotes preventing
T15118 4903-4906 DT denotes the
T15119 4907-4922 NN denotes phosphorylation
T15120 4923-4925 IN denotes of
T15121 4926-4932 NN denotes GATA-3
T15122 4933-4937 WDT denotes that
T15123 4938-4940 VBZ denotes is
T15124 4941-4950 JJ denotes necessary
T15125 4951-4954 IN denotes for
T15126 4955-4962 JJ denotes nuclear
T15127 4963-4976 NN denotes translocation
T15128 4977-4979 IN denotes of
T15129 4980-4986 NN denotes GATA-3
T15130 4986-4987 . denotes .
T15131 4988-4993 DT denotes These
T15132 4994-4997 CD denotes two
T15133 4998-5008 NNS denotes mechanisms
T15134 5009-5012 VBP denotes are
T15135 5013-5019 JJ denotes likely
T15136 5020-5022 TO denotes to
T15137 5023-5025 VB denotes be
T15138 5026-5037 JJ denotes synergistic
T15139 5037-5038 , denotes ,
T15140 5039-5049 VBG denotes accounting
T15141 5050-5053 IN denotes for
T15142 5054-5057 DT denotes the
T15143 5058-5063 JJ denotes rapid
T15144 5064-5067 CC denotes and
T15145 5068-5074 JJ denotes potent
T15146 5075-5081 NN denotes effect
T15147 5082-5084 IN denotes of
T15148 5085-5100 NNS denotes corticosteroids
T15149 5101-5103 IN denotes on
T15150 5104-5112 JJ denotes allergic
T15151 5113-5125 NN denotes inflammation
T15152 5125-5126 . denotes .
T15153 5127-5131 DT denotes This
T15154 5132-5134 VBZ denotes is
T15155 5135-5146 VBN denotes exemplified
T15156 5147-5149 IN denotes by
T15157 5150-5153 DT denotes the
T15158 5154-5159 JJ denotes rapid
T15159 5160-5170 JJ denotes inhibitory
T15160 5171-5177 NN denotes effect
T15161 5178-5180 IN denotes of
T15162 5181-5188 JJ denotes topical
T15163 5189-5204 NNS denotes corticosteroids
T15164 5205-5207 IN denotes on
T15165 5208-5213 JJ denotes nasal
T15166 5214-5217 JJ denotes Th2
T15167 5218-5226 NN denotes cytokine
T15168 5227-5234 NN denotes release
T15169 5235-5240 IN denotes after
T15170 5241-5249 NN denotes allergen
T15171 5250-5261 NN denotes provocation
T15172 5262-5264 IN denotes in
T15173 5265-5276 NNS denotes individuals
T15174 5277-5281 IN denotes with
T15175 5282-5290 JJ denotes seasonal
T15176 5291-5299 JJ denotes allergic
T15177 5300-5308 NN denotes rhinitis
T15178 5309-5310 -LRB- denotes (
T15179 5310-5313 NN denotes hay
T15180 5314-5319 NN denotes fever
T15181 5319-5320 -RRB- denotes )
T15182 5321-5322 NNP denotes [
T15183 5322-5324 CD denotes 43
T15184 5324-5325 NNP denotes ]
T15185 5325-5326 . denotes .
T15186 5327-5337 NNP denotes Prevention
T15187 5338-5340 IN denotes of
T15188 5341-5355 JJ denotes phospho-GATA-3
T15189 5356-5367 NN denotes interaction
T15190 5368-5372 IN denotes with
T15191 5373-5383 NN denotes importin-α
T15192 5384-5387 MD denotes may
T15193 5388-5395 VB denotes provide
T15194 5396-5397 DT denotes a
T15195 5398-5401 JJ denotes new
T15196 5402-5410 NN denotes approach
T15197 5411-5414 IN denotes for
T15198 5415-5418 DT denotes the
T15199 5419-5430 NN denotes development
T15200 5431-5433 IN denotes of
T15201 5434-5439 NN denotes novel
T15202 5440-5449 NNS denotes therapies
T15203 5450-5453 IN denotes for
T15204 5454-5457 DT denotes the
T15205 5458-5467 NN denotes treatment
T15206 5468-5470 IN denotes of
T15207 5471-5479 JJ denotes allergic
T15208 5480-5488 NNS denotes diseases
T15209 5488-5489 . denotes .
R12321 T14309 T14312 advmod Here,demonstrated
R12322 T14310 T14312 nsubj we,demonstrated
R12323 T14311 T14312 aux have,demonstrated
R12324 T14312 T14312 ROOT demonstrated,demonstrated
R12325 T14313 T14312 punct ",",demonstrated
R12326 T14314 T14312 prep to,demonstrated
R12327 T14315 T14316 poss our,knowledge
R12328 T14316 T14314 pobj knowledge,to
R12329 T14317 T14316 prep for,knowledge
R12330 T14318 T14320 det the,time
R12331 T14319 T14320 amod first,time
R12332 T14320 T14317 pobj time,for
R12333 T14321 T14312 punct ",",demonstrated
R12334 T14322 T14325 mark that,inhibit
R12335 T14323 T14325 nsubj corticosteroids,inhibit
R12336 T14324 T14325 aux may,inhibit
R12337 T14325 T14312 ccomp inhibit,demonstrated
R12338 T14326 T14327 compound GATA-3,function
R12339 T14327 T14325 dobj function,inhibit
R12340 T14328 T14325 cc and,inhibit
R12341 T14329 T14331 advmod therefore,transcription
R12342 T14330 T14331 det the,transcription
R12343 T14331 T14325 conj transcription,inhibit
R12344 T14332 T14331 prep of,transcription
R12345 T14333 T14334 amod Th2,genes
R12346 T14334 T14332 pobj genes,of
R12347 T14335 T14331 prep via,transcription
R12348 T14336 T14341 nummod two,mechanisms
R12349 T14337 T14341 amod distinct,mechanisms
R12350 T14338 T14337 cc but,distinct
R12390 T14378 T14378 ROOT increase,increase
R12391 T14379 T14380 det the,expression
R12392 T14380 T14378 dobj expression,increase
R12393 T14381 T14380 prep of,expression
R12394 T14382 T14381 pobj MKP-1,of
R12395 T14383 T14382 punct ",",MKP-1
R12396 T14384 T14386 det a,inhibitor
R12397 T14385 T14386 amod potent,inhibitor
R12398 T14386 T14382 appos inhibitor,MKP-1
R12399 T14387 T14386 prep of,inhibitor
R12400 T14388 T14390 nummod p38,activity
R12401 T14389 T14390 compound MAPK,activity
R12402 T14390 T14387 pobj activity,of
R12403 T14391 T14378 cc and,increase
R12404 T14392 T14393 advmod thereby,prevent
R12405 T14393 T14378 conj prevent,increase
R12406 T14394 T14397 compound T,activation
R12407 T14395 T14396 compound cell,receptor/co-receptor
R12408 T14396 T14397 compound receptor/co-receptor,activation
R12409 T14397 T14393 dobj activation,prevent
R12410 T14398 T14397 prep of,activation
R12411 T14399 T14400 nummod p38,MAPK
R12412 T14400 T14398 pobj MAPK,of
R12413 T14401 T14402 aux to,prevent
R12414 T14402 T14393 advcl prevent,prevent
R12415 T14403 T14404 det the,phosphorylation
R12416 T14404 T14402 dobj phosphorylation,prevent
R12417 T14405 T14404 prep of,phosphorylation
R12418 T14406 T14405 pobj GATA-3,of
R12419 T14407 T14408 nsubj that,is
R12420 T14408 T14406 relcl is,GATA-3
R12421 T14409 T14408 acomp necessary,is
R12422 T14410 T14409 prep for,necessary
R12423 T14411 T14410 pobj interaction,for
R12424 T14412 T14411 prep with,interaction
R12425 T14413 T14412 pobj importin-α,with
R12426 T14414 T14413 cc and,importin-α
R12427 T14415 T14417 amod subsequent,import
R12428 T14416 T14417 amod nuclear,import
R12429 T14417 T14413 conj import,importin-α
R12458 T14446 T14447 nummod 12,]
R12459 T14447 T14445 appos ],[
R12460 T14448 T14422 punct .,shown
R12461 T14449 T14453 nsubj We,reported
R12462 T14450 T14453 aux have,reported
R12463 T14451 T14453 advmod also,reported
R12464 T14452 T14453 advmod previously,reported
R12465 T14453 T14453 ROOT reported,reported
R12466 T14454 T14466 mark that,stimulated
R12467 T14455 T14456 amod GATA-3,knockdown
R12468 T14456 T14466 nsubj knockdown,stimulated
R12469 T14457 T14456 acl using,knockdown
R12470 T14458 T14459 compound siRNA,results
R12471 T14459 T14457 dobj results,using
R12472 T14460 T14459 prep in,results
R12473 T14461 T14460 pobj suppression,in
R12474 T14462 T14461 prep of,suppression
R12475 T14463 T14464 compound anti-CD3,/
R12476 T14464 T14465 compound /,CD28
R12477 T14465 T14462 pobj CD28,of
R12478 T14466 T14453 ccomp stimulated,reported
R12479 T14467 T14469 compound IL-4,IL-5
R12480 T14468 T14469 compound /,IL-5
R12481 T14469 T14470 compound IL-5,mRNA
R12482 T14470 T14471 compound mRNA,induction
R12483 T14471 T14466 dobj induction,stimulated
R12484 T14472 T14466 punct ",",stimulated
R12485 T14473 T14474 advmod thus,implicating
R12486 T14474 T14466 prep implicating,stimulated
R12487 T14475 T14477 det an,role
R12488 T14476 T14477 amod essential,role
R12489 T14477 T14474 dobj role,implicating
R12490 T14478 T14477 prep for,role
R12491 T14479 T14478 pobj GATA-3,for
R12492 T14480 T14477 prep in,role
R12493 T14481 T14482 det the,transcription
R12494 T14482 T14480 pobj transcription,in
R12495 T14483 T14482 prep of,transcription
R12496 T14484 T14485 det these,genes
R12497 T14485 T14483 pobj genes,of
R12498 T14486 T14488 nmod [,]
R12499 T14487 T14488 nummod 12,]
R12500 T14488 T14482 appos ],transcription
R12501 T14489 T14453 punct .,reported
R12502 T14490 T14492 nsubj We,confirm
R12503 T14491 T14492 advmod now,confirm
R12504 T14492 T14492 ROOT confirm,confirm
R12505 T14493 T14492 punct ",",confirm
R12506 T14494 T14492 prep in,confirm
R12507 T14495 T14497 amod human,cells
R12508 T14496 T14497 compound T,cells
R12509 T14497 T14494 pobj cells,in
R12510 T14498 T14492 punct ",",confirm
R12511 T14499 T14502 mark that,uses
R12512 T14500 T14502 nsubj GR,uses
R12513 T14501 T14502 advmod also,uses
R12514 T14502 T14492 ccomp uses,confirm
R12515 T14503 T14507 det the,mechanism
R12516 T14504 T14507 amod same,mechanism
R12517 T14505 T14507 amod nuclear,mechanism
R12518 T14506 T14507 compound import,mechanism
R12519 T14507 T14502 dobj mechanism,uses
R12520 T14508 T14502 prep as,uses
R12521 T14509 T14510 compound GATA-3,[
R12522 T14510 T14508 pobj [,as
R12523 T14511 T14512 nummod 22,]
R12524 T14512 T14510 appos ],[
R12525 T14513 T14492 punct .,confirm
R12526 T14514 T14516 nsubj We,propose
R12527 T14515 T14516 advmod therefore,propose
R12528 T14516 T14516 ROOT propose,propose
R12529 T14517 T14519 mark that,is
R12530 T14518 T14519 expl there,is
R12531 T14519 T14516 ccomp is,propose
R12532 T14520 T14519 attr competition,is
R12533 T14521 T14520 prep between,competition
R12534 T14522 T14523 compound ligand-activated,GR
R12535 T14523 T14521 pobj GR,between
R12536 T14524 T14523 cc and,GR
R12537 T14525 T14523 conj phospho-GATA-3,GR
R12538 T14526 T14520 prep for,competition
R12539 T14527 T14528 amod nuclear,import
R12540 T14528 T14526 pobj import,for
R12541 T14529 T14516 punct .,propose
R12542 T14530 T14534 advmod Furthermore,shown
R12543 T14531 T14534 punct ",",shown
R12544 T14532 T14534 nsubj we,shown
R12545 T14533 T14534 aux have,shown
R12546 T14534 T14534 ROOT shown,shown
R12547 T14535 T14537 mark that,is
R12548 T14536 T14537 expl there,is
R12549 T14537 T14534 ccomp is,shown
R12550 T14538 T14539 amod preferential,binding
R12551 T14539 T14537 attr binding,is
R12552 T14540 T14539 prep of,binding
R12553 T14541 T14540 pobj importin-α,of
R12554 T14542 T14543 aux to,activated
R12555 T14543 T14534 xcomp activated,shown
R12556 T14544 T14543 dobj GR,activated
R12557 T14545 T14543 prep over,activated
R12558 T14546 T14545 pobj phospho-GATA-3,over
R12559 T14547 T14534 punct ",",shown
R12560 T14548 T14553 mark so,reduce
R12561 T14549 T14553 mark that,reduce
R12562 T14550 T14553 nsubj corticosteroids,reduce
R12563 T14551 T14553 aux would,reduce
R12564 T14552 T14553 advmod preferentially,reduce
R12565 T14553 T14534 advcl reduce,shown
R12566 T14554 T14555 compound GATA-3,entry
R12567 T14555 T14553 dobj entry,reduce
R12568 T14556 T14553 cc and,reduce
R12569 T14557 T14559 advmod thus,switch
R12570 T14558 T14559 advmod rapidly,switch
R12571 T14559 T14553 conj switch,reduce
R12572 T14560 T14559 prt off,switch
R12573 T14561 T14563 nummod Th2,transcription
R12574 T14562 T14563 compound gene,transcription
R12575 T14563 T14559 dobj transcription,switch
R12576 T14564 T14559 prep without,switch
R12577 T14565 T14566 det any,need
R12578 T14566 T14564 pobj need,without
R12579 T14567 T14566 prep for,need
R12580 T14568 T14570 det any,steps
R12581 T14569 T14570 amod intermediate,steps
R12582 T14570 T14567 pobj steps,for
R12583 T14571 T14534 punct .,shown
R12584 T14572 T14575 advmod Furthermore,was
R12585 T14573 T14575 punct ",",was
R12586 T14574 T14575 expl there,was
R12587 T14575 T14575 ROOT was,was
R12588 T14576 T14577 det some,degree
R12589 T14577 T14575 attr degree,was
R12590 T14578 T14577 prep of,degree
R12591 T14579 T14578 pobj specificity,of
R12592 T14580 T14577 prep for,degree
R12593 T14581 T14580 pobj GATA-3,for
R12594 T14582 T14577 punct ",",degree
R12595 T14583 T14594 mark as,affected
R12596 T14584 T14585 amod nuclear,translocation
R12597 T14585 T14583 pobj translocation,as
R12598 T14586 T14585 prep of,translocation
R12599 T14587 T14589 det the,subunit
R12600 T14588 T14589 nummod p65,subunit
R12601 T14589 T14586 pobj subunit,of
R12602 T14590 T14589 prep of,subunit
R12603 T14591 T14590 pobj NF-κB,of
R12604 T14592 T14594 auxpass was,affected
R12605 T14593 T14594 neg not,affected
R12606 T14594 T14575 advcl affected,was
R12607 T14595 T14594 agent by,affected
R12608 T14596 T14597 amod corticosteroid,exposure
R12609 T14597 T14595 pobj exposure,by
R12610 T14598 T14575 punct .,was
R12611 T14599 T14600 nsubj We,tested
R12612 T14600 T14600 ROOT tested,tested
R12613 T14601 T14603 det some,explanations
R12614 T14602 T14603 amod alternative,explanations
R12615 T14603 T14600 dobj explanations,tested
R12616 T14604 T14603 prep for,explanations
R12617 T14605 T14606 det this,effect
R12618 T14606 T14604 pobj effect,for
R12619 T14607 T14606 prep of,effect
R12620 T14608 T14607 pobj FP,of
R12621 T14609 T14606 prep on,effect
R12622 T14610 T14612 nmod GATA-3,exclusion
R12623 T14611 T14612 amod nuclear,exclusion
R12624 T14612 T14609 pobj exclusion,on
R12625 T14613 T14600 cc and,tested
R12626 T14614 T14600 conj failed,tested
R12627 T14615 T14616 aux to,show
R12628 T14616 T14614 xcomp show,failed
R12629 T14617 T14620 mark that,enhances
R12630 T14618 T14620 nsubj FP,enhances
R12631 T14619 T14620 preconj either,enhances
R12632 T14620 T14616 ccomp enhances,show
R12633 T14621 T14623 amod GATA-3,export
R12634 T14622 T14623 amod nuclear,export
R12635 T14623 T14620 dobj export,enhances
R12636 T14624 T14620 advmod directly,enhances
R12637 T14625 T14620 cc or,enhances
R12638 T14626 T14620 conj induces,enhances
R12639 T14627 T14628 amod GATA-3,degradation
R12640 T14628 T14626 dobj degradation,induces
R12641 T14629 T14600 punct .,tested
R12642 T14630 T14631 det The,evidence
R12643 T14631 T14638 nsubj evidence,does
R12644 T14632 T14631 prep from,evidence
R12645 T14633 T14638 det the,does
R12646 T14634 T14638 prep in,does
R12647 T14635 T14636 amod vitro,competition
R12648 T14636 T14637 compound competition,assays
R12649 T14637 T14634 pobj assays,in
R12650 T14638 T14642 aux does,suggest
R12651 T14639 T14642 punct ",",suggest
R12652 T14640 T14642 advmod however,suggest
R12653 T14641 T14642 punct ",",suggest
R12654 T14642 T14642 ROOT suggest,suggest
R12655 T14643 T14649 mark that,attenuate
R12656 T14644 T14646 amod purified,GR
R12657 T14645 T14646 amod activated,GR
R12658 T14646 T14649 nsubj GR,attenuate
R12659 T14647 T14649 aux can,attenuate
R12660 T14648 T14649 advmod clearly,attenuate
R12661 T14649 T14642 ccomp attenuate,suggest
R12662 T14650 T14651 amod purified,phospho-GATA-3
R12663 T14651 T14649 dobj phospho-GATA-3,attenuate
R12664 T14652 T14653 amod importin-α,association
R12665 T14653 T14651 appos association,phospho-GATA-3
R12666 T14654 T14649 cc and,attenuate
R12667 T14655 T14660 mark that,occur
R12668 T14656 T14657 det the,converse
R12669 T14657 T14660 nsubj converse,occur
R12670 T14658 T14660 aux does,occur
R12671 T14659 T14660 neg not,occur
R12672 T14660 T14649 conj occur,attenuate
R12673 T14661 T14642 punct .,suggest
R12674 T14662 T14666 advmod Furthermore,shown
R12675 T14663 T14666 punct ",",shown
R12676 T14664 T14666 nsubj we,shown
R12677 T14665 T14666 aux have,shown
R12678 T14666 T14666 ROOT shown,shown
R12679 T14667 T14671 mark that,associate
R12680 T14668 T14669 advmod only,phospho-GATA-3
R12681 T14669 T14671 nsubj phospho-GATA-3,associate
R12682 T14670 T14671 aux can,associate
R12683 T14671 T14666 ccomp associate,shown
R12684 T14672 T14671 prep with,associate
R12685 T14673 T14672 pobj importin-α,with
R12686 T14674 T14666 punct .,shown
R12687 T14675 T14676 det This,mechanism
R12688 T14676 T14677 nsubj mechanism,is
R12689 T14677 T14677 ROOT is,is
R12690 T14678 T14677 acomp sensitive,is
R12691 T14679 T14678 prep to,sensitive
R12692 T14680 T14681 advmod very,low
R12693 T14681 T14682 amod low,concentrations
R12694 T14682 T14679 pobj concentrations,to
R12695 T14683 T14682 prep of,concentrations
R12696 T14684 T14683 pobj corticosteroid,of
R12697 T14685 T14677 cc and,is
R12698 T14686 T14687 aux would,be
R12699 T14687 T14677 conj be,is
R12700 T14688 T14687 acomp rapid,be
R12701 T14689 T14688 prep in,rapid
R12702 T14690 T14689 pobj onset,in
R12703 T14691 T14698 mark as,required
R12704 T14692 T14693 det no,changes
R12705 T14693 T14698 nsubjpass changes,required
R12706 T14694 T14693 prep in,changes
R12707 T14695 T14696 compound protein,synthesis
R12741 T14729 T14728 prep to,prior
R12742 T14730 T14731 compound MKP-1,induction
R12743 T14731 T14729 pobj induction,to
R12744 T14732 T14705 punct .,contribute
R12745 T14733 T14735 nsubj Corticosteroids,modulate
R12746 T14734 T14735 aux can,modulate
R12747 T14735 T14735 ROOT modulate,modulate
R12748 T14736 T14738 nummod p38,activity
R12749 T14737 T14738 compound MAPK,activity
R12750 T14738 T14735 dobj activity,modulate
R12751 T14739 T14735 prep through,modulate
R12752 T14740 T14741 det the,induction
R12753 T14741 T14739 pobj induction,through
R12754 T14742 T14741 prep of,induction
R12755 T14743 T14742 pobj MKP-1,of
R12756 T14744 T14743 punct ",",MKP-1
R12757 T14745 T14748 det a,inhibitor
R12758 T14746 T14748 amod potent,inhibitor
R12759 T14747 T14748 amod endogenous,inhibitor
R12760 T14748 T14743 appos inhibitor,MKP-1
R12761 T14749 T14748 prep of,inhibitor
R12762 T14750 T14751 compound MAPK,function
R12763 T14751 T14749 pobj function,of
R12764 T14752 T14754 nmod [,]
R12765 T14753 T14754 nummod 38,]
R12766 T14754 T14748 appos ],inhibitor
R12767 T14755 T14754 punct ",",]
R12768 T14756 T14758 nmod [,]
R12769 T14757 T14758 nummod 39,]
R12770 T14758 T14754 appos ],]
R12771 T14759 T14735 punct .,modulate
R12772 T14760 T14761 nsubj We,report
R12773 T14761 T14761 ROOT report,report
R12774 T14762 T14761 advmod here,report
R12775 T14763 T14765 det a,induction
R12776 T14764 T14765 amod rapid,induction
R12777 T14765 T14761 dobj induction,report
R12778 T14766 T14765 prep of,induction
R12779 T14767 T14768 compound MKP-1,mRNA
R12780 T14768 T14766 pobj mRNA,of
R12781 T14769 T14765 prep following,induction
R12782 T14770 T14769 pobj stimulation,following
R12783 T14771 T14770 prep of,stimulation
R12784 T14772 T14771 pobj cells,of
R12785 T14773 T14772 prep with,cells
R12786 T14774 T14775 advmod relatively,high
R12787 T14775 T14776 amod high,concentrations
R12788 T14776 T14773 pobj concentrations,with
R12789 T14777 T14776 prep of,concentrations
R12790 T14778 T14777 pobj FP,of
R12791 T14779 T14761 punct .,report
R12792 T14780 T14781 nsubj We,hypothesize
R12793 T14781 T14781 ROOT hypothesize,hypothesize
R12794 T14782 T14789 mark that,reduce
R12795 T14783 T14785 det this,induction
R12796 T14784 T14785 amod rapid,induction
R12797 T14785 T14789 nsubj induction,reduce
R12798 T14786 T14785 prep of,induction
R12799 T14787 T14786 pobj MKP-1,of
R12800 T14788 T14789 aux can,reduce
R12801 T14789 T14781 ccomp reduce,hypothesize
R12802 T14790 T14792 amod GATA-3,import
R12803 T14791 T14792 amod nuclear,import
R12804 T14792 T14789 dobj import,reduce
R12805 T14793 T14789 prep by,reduce
R12806 T14794 T14793 pcomp attenuating,by
R12807 T14795 T14797 nummod p38,activity
R12808 T14796 T14797 compound MAPK,activity
R12809 T14797 T14794 dobj activity,attenuating
R12810 T14798 T14797 cc and,activity
R12811 T14799 T14801 amod subsequent,phosphorylation
R12812 T14800 T14801 compound GATA-3,phosphorylation
R12813 T14801 T14797 conj phosphorylation,activity
R12814 T14802 T14789 punct ",",reduce
R12815 T14803 T14804 advmod thus,preventing
R12816 T14804 T14789 advcl preventing,reduce
R12817 T14805 T14806 amod nuclear,translocation
R12818 T14806 T14804 dobj translocation,preventing
R12819 T14807 T14781 punct .,hypothesize
R12820 T14808 T14809 det The,location
R12821 T14809 T14825 nsubj location,are
R12822 T14810 T14809 prep of,location
R12823 T14811 T14813 det the,residue
R12824 T14812 T14813 compound serine,residue
R12825 T14813 T14810 pobj residue,of
R12826 T14814 T14813 punct (,residue
R12827 T14815 T14813 appos s,residue
R12828 T14816 T14813 punct ),residue
R12829 T14817 T14813 prep of,residue
R12830 T14818 T14817 pobj GATA-3,of
R12831 T14819 T14821 nsubjpass that,phosphorylated
R12832 T14820 T14821 auxpass are,phosphorylated
R12833 T14821 T14813 relcl phosphorylated,residue
R12834 T14822 T14821 agent by,phosphorylated
R12835 T14823 T14824 nummod p38,MAPK
R12836 T14824 T14822 pobj MAPK,by
R12837 T14825 T14825 ROOT are,are
R12838 T14826 T14825 advmod currently,are
R12839 T14827 T14825 acomp unknown,are
R12840 T14828 T14825 punct ",",are
R12841 T14829 T14825 cc but,are
R12842 T14830 T14832 det a,search
R12843 T14831 T14832 compound bioinformatics,search
R12844 T14832 T14839 nsubj search,indicates
R12845 T14833 T14832 punct (,search
R12846 T14834 T14835 compound Motif,Scanner
R12847 T14835 T14832 appos Scanner,search
R12848 T14836 T14835 punct ",",Scanner
R12849 T14837 T14835 appos http://scansite.mit.edu/motifscan_seq.phtml,Scanner
R12850 T14838 T14835 punct ),Scanner
R12851 T14839 T14825 conj indicates,are
R12852 T14840 T14841 advmod at,least
R12853 T14841 T14842 advmod least,three
R12854 T14842 T14847 nummod three,residues
R12855 T14843 T14847 amod potential,residues
R12856 T14844 T14847 nummod p38,residues
R12857 T14845 T14847 amod MAPK-sensitive,residues
R12858 T14846 T14847 compound serine,residues
R12859 T14847 T14839 dobj residues,indicates
R12860 T14848 T14839 punct .,indicates
R12861 T14849 T14850 mark As,predicted
R12862 T14850 T14871 advcl predicted,underlie
R12863 T14851 T14850 prep from,predicted
R12864 T14852 T14851 pobj these,from
R12865 T14853 T14850 prep in,predicted
R12866 T14854 T14855 compound vitro,data
R12867 T14855 T14853 pobj data,in
R12868 T14856 T14855 punct ",",data
R12869 T14857 T14871 nsubj impairment,underlie
R12870 T14858 T14857 prep of,impairment
R12871 T14859 T14861 amod GATA-3,import
R12872 T14860 T14861 amod nuclear,import
R12873 T14861 T14858 pobj import,of
R12874 T14862 T14857 prep by,impairment
R12875 T14863 T14862 pobj FP,by
R12876 T14864 T14871 aux may,underlie
R12877 T14865 T14871 punct ",",underlie
R12878 T14866 T14867 advmod at,least
R12879 T14867 T14868 advmod least,in
R12880 T14868 T14871 prep in,underlie
R12881 T14869 T14868 pobj part,in
R12882 T14870 T14871 punct ",",underlie
R12883 T14871 T14871 ROOT underlie,underlie
R12884 T14872 T14873 det the,efficacy
R12885 T14873 T14871 dobj efficacy,underlie
R12886 T14874 T14873 prep of,efficacy
R12887 T14875 T14874 pobj corticosteroids,of
R12888 T14876 T14871 prep in,underlie
R12889 T14877 T14876 pcomp suppressing,in
R12890 T14878 T14879 amod allergic,inflammation
R12891 T14879 T14877 dobj inflammation,suppressing
R12892 T14880 T14871 punct .,underlie
R12893 T14881 T14885 mark Although,assess
R12894 T14882 T14885 nsubj we,assess
R12895 T14883 T14885 aux did,assess
R12896 T14884 T14885 neg not,assess
R12897 T14885 T14911 advcl assess,have
R12898 T14886 T14889 det the,effect
R12899 T14887 T14889 amod acute,effect
R12900 T14888 T14889 amod inhibitory,effect
R12901 T14889 T14885 dobj effect,assess
R12902 T14890 T14889 prep of,effect
R12903 T14891 T14890 pobj FP,of
R12904 T14892 T14889 prep on,effect
R12905 T14893 T14894 det the,expression
R12906 T14894 T14892 pobj expression,on
R12907 T14895 T14894 prep of,expression
R12908 T14896 T14897 compound IL-4,mRNA
R12909 T14897 T14895 pobj mRNA,of
R12910 T14898 T14889 prep in,effect
R12911 T14899 T14898 pobj vivo,in
R12912 T14900 T14899 punct ",",vivo
R12913 T14901 T14903 det a,inhalation
R12914 T14902 T14903 amod single,inhalation
R12915 T14903 T14911 nsubj inhalation,have
R12916 T14904 T14903 prep of,inhalation
R12917 T14905 T14904 pobj FP,of
R12918 T14906 T14905 punct (,FP
R12919 T14907 T14908 nummod 500,µg
R12920 T14908 T14905 appos µg,FP
R12921 T14909 T14905 punct ),FP
R12922 T14910 T14911 aux may,have
R12923 T14911 T14911 ROOT have,have
R12924 T14912 T14913 amod comparable,effects
R12925 T14913 T14911 dobj effects,have
R12926 T14914 T14911 punct ",",have
R12927 T14915 T14917 mark as,provides
R12928 T14916 T14917 nsubj it,provides
R12929 T14917 T14911 advcl provides,have
R12930 T14918 T14919 compound plasma,levels
R12931 T14919 T14917 dobj levels,provides
R12932 T14920 T14917 prep within,provides
R12933 T14921 T14923 det a,range
R12934 T14922 T14923 amod relevant,range
R12935 T14923 T14920 pobj range,within
R12936 T14924 T14923 prep of,range
R12937 T14925 T14924 pobj concentrations,of
R12938 T14926 T14911 advcl used,have
R12939 T14927 T14928 aux to,suppress
R12940 T14928 T14926 xcomp suppress,used
R12941 T14929 T14930 compound IL-4,transcription
R12942 T14930 T14928 dobj transcription,suppress
R12943 T14931 T14928 prep in,suppress
R12944 T14932 T14931 pobj our,in
R12945 T14933 T14928 prep in,suppress
R12946 T14934 T14935 amod vitro,system
R12947 T14935 T14933 pobj system,in
R12948 T14936 T14938 nmod [,]
R12949 T14937 T14938 nummod 37,]
R12950 T14938 T14928 conj ],suppress
R12951 T14939 T14911 punct .,have
R12952 T14940 T14942 det A,dose
R12953 T14941 T14942 amod lower,dose
R12954 T14942 T14950 nsubj dose,was
R12955 T14943 T14942 prep of,dose
R12956 T14944 T14945 amod inhaled,FP
R12957 T14945 T14943 pobj FP,of
R12958 T14946 T14945 punct (,FP
R12959 T14947 T14948 nummod 100,µg
R12960 T14948 T14945 appos µg,FP
R12961 T14949 T14948 punct ),µg
R12962 T14950 T14950 ROOT was,was
R12963 T14951 T14950 neg not,was
R12964 T14952 T14950 acomp effective,was
R12965 T14953 T14950 punct ",",was
R12966 T14954 T14950 cc but,was
R12967 T14955 T14956 compound plasma,concentrations
R12968 T14956 T14958 nsubj concentrations,be
R12969 T14957 T14958 aux may,be
R12970 T14958 T14950 conj be,was
R12971 T14959 T14958 prep below,be
R12972 T14960 T14959 pobj those,below
R12973 T14961 T14960 acl required,those
R12974 T14962 T14961 prep for,required
R12975 T14963 T14964 amod GATA-3,inhibition
R12976 T14964 T14962 pobj inhibition,for
R12977 T14965 T14958 punct .,be
R12978 T14966 T14969 advmod However,is
R12979 T14967 T14969 punct ",",is
R12980 T14968 T14969 nsubj it,is
R12981 T14969 T14969 ROOT is,is
R12982 T14970 T14969 acomp likely,is
R12983 T14971 T14984 mark that,be
R12984 T14972 T14974 det the,concentrations
R12985 T14973 T14974 amod higher,concentrations
R12986 T14974 T14984 nsubj concentrations,be
R12987 T14975 T14974 prep of,concentrations
R12988 T14976 T14975 pobj FP,of
R12989 T14977 T14974 prep in,concentrations
R12990 T14978 T14979 det the,airways
R12991 T14979 T14977 pobj airways,in
R12992 T14980 T14974 prep after,concentrations
R12993 T14981 T14982 amod inhaled,administration
R12994 T14982 T14980 pobj administration,after
R12995 T14983 T14984 aux would,be
R12996 T14984 T14970 ccomp be,likely
R12997 T14985 T14984 acomp effective,be
R12998 T14986 T14985 prep in,effective
R12999 T14987 T14986 pcomp inhibiting,in
R13000 T14988 T14987 dobj GATA-3,inhibiting
R13001 T14989 T14987 prep in,inhibiting
R13002 T14990 T14991 compound airway,T
R13003 T14991 T14992 compound T,cells
R13004 T14992 T14989 pobj cells,in
R13005 T14993 T14992 prep of,cells
R13006 T14994 T14995 compound asthma,patients
R13007 T14995 T14993 pobj patients,of
R13008 T14996 T14969 punct .,is
R13009 T14997 T14998 det The,study
R13010 T14998 T15010 nsubj study,demonstrates
R13011 T14999 T14998 prep of,study
R13012 T15000 T14999 pobj PBMCs,of
R13013 T15001 T14998 prep from,study
R13014 T15002 T15003 compound asthma,patients
R13015 T15003 T15001 pobj patients,from
R13016 T15004 T14998 acl treated,study
R13017 T15005 T15004 prep with,treated
R13018 T15006 T15008 amod inhaled,therapy
R13019 T15007 T15008 amod corticosteroid,therapy
R13020 T15008 T15005 pobj therapy,with
R13021 T15009 T15010 advmod clearly,demonstrates
R13022 T15010 T15010 ROOT demonstrates,demonstrates
R13023 T15011 T15015 mark that,are
R13024 T15012 T15014 det these,mechanisms
R13025 T15013 T15014 amod molecular,mechanisms
R13026 T15014 T15015 nsubj mechanisms,are
R13027 T15015 T15010 ccomp are,demonstrates
R13028 T15016 T15015 acomp likely,are
R13029 T15017 T15019 aux to,occur
R13030 T15018 T15019 advmod also,occur
R13031 T15019 T15016 xcomp occur,likely
R13032 T15020 T15019 prep in,occur
R13033 T15021 T15020 pobj patients,in
R13034 T15022 T15021 prep at,patients
R13035 T15023 T15024 amod therapeutic,doses
R13036 T15024 T15022 pobj doses,at
R13037 T15025 T15024 prep of,doses
R13038 T15026 T15027 amod inhaled,corticosteroids
R13039 T15027 T15025 pobj corticosteroids,of
R13040 T15028 T15010 punct .,demonstrates
R13041 T15029 T15035 prep In,shown
R13042 T15030 T15029 pobj addition,In
R13043 T15031 T15035 punct ",",shown
R13044 T15032 T15033 amod previous,studies
R13045 T15033 T15035 nsubj studies,shown
R13046 T15034 T15035 aux have,shown
R13047 T15035 T15035 ROOT shown,shown
R13048 T15036 T15039 mark that,suppress
R13049 T15037 T15039 nsubj corticosteroids,suppress
R13050 T15038 T15039 aux can,suppress
R13051 T15039 T15035 ccomp suppress,shown
R13052 T15040 T15043 nmod IL-4,release
R13053 T15041 T15040 cc and,IL-4
R13054 T15042 T15043 compound IL-5,release
R13055 T15043 T15039 dobj release,suppress
R13056 T15044 T15043 prep from,release
R13057 T15045 T15047 amod peripheral,cells
R13058 T15046 T15047 compound blood,cells
R13059 T15047 T15044 pobj cells,from
R13060 T15048 T15047 prep of,cells
R13061 T15049 T15050 compound asthma,patients
R13062 T15050 T15048 pobj patients,of
R13063 T15051 T15043 prep in,release
R13064 T15052 T15051 pobj vitro,in
R13065 T15053 T15051 cc and,in
R13066 T15054 T15051 conj in,in
R13067 T15055 T15056 compound vivo,[
R13068 T15056 T15054 pobj [,in
R13069 T15057 T15058 nummod 40,]
R13070 T15058 T15056 appos ],[
R13071 T15059 T15056 appos [,[
R13072 T15060 T15061 nummod 42,]
R13073 T15061 T15056 appos ],[
R13074 T15062 T15035 punct .,shown
R13075 T15063 T15068 prep In,provide
R13076 T15064 T15063 pobj summary,In
R13077 T15065 T15068 punct ",",provide
R13078 T15066 T15067 poss our,data
R13079 T15067 T15068 nsubj data,provide
R13080 T15068 T15068 ROOT provide,provide
R13081 T15069 T15068 dobj evidence,provide
R13082 T15070 T15069 prep for,evidence
R13083 T15071 T15073 det a,action
R13084 T15072 T15073 compound novel,action
R13085 T15073 T15070 pobj action,for
R13086 T15074 T15073 prep of,action
R13087 T15075 T15074 pobj corticosteroids,of
R13088 T15076 T15069 punct :,evidence
R13089 T15077 T15069 conj suppression,evidence
R13090 T15078 T15077 prep of,suppression
R13091 T15079 T15080 amod allergic,inflammation
R13092 T15080 T15078 pobj inflammation,of
R13093 T15081 T15068 prep through,provide
R13094 T15082 T15085 det a,effect
R13095 T15083 T15085 amod rapid,effect
R13096 T15084 T15085 amod inhibitory,effect
R13097 T15085 T15081 pobj effect,through
R13098 T15086 T15085 prep on,effect
R13099 T15087 T15089 amod GATA-3,translocation
R13100 T15088 T15089 amod nuclear,translocation
R13101 T15089 T15086 pobj translocation,on
R13102 T15090 T15085 prep by,effect
R13103 T15091 T15092 amod preferential,binding
R13104 T15092 T15085 amod binding,effect
R13105 T15093 T15092 prep to,binding
R13106 T15094 T15098 det the,protein
R13107 T15095 T15098 amod shared,protein
R13108 T15096 T15097 amod nuclear,import
R13109 T15097 T15098 compound import,protein
R13110 T15098 T15099 compound protein,importin-α
R13111 T15099 T15093 pobj importin-α,to
R13112 T15100 T15081 cc and,through
R13113 T15101 T15081 conj by,through
R13114 T15102 T15104 det a,mechanism
R13115 T15103 T15104 amod second,mechanism
R13116 T15104 T15101 pobj mechanism,by
R13117 T15105 T15104 acl involving,mechanism
R13118 T15106 T15107 amod increased,synthesis
R13119 T15107 T15068 dobj synthesis,provide
R13120 T15108 T15107 prep of,synthesis
R13121 T15109 T15108 pobj MKP-1,of
R13122 T15110 T15109 punct ",",MKP-1
R13123 T15111 T15112 nsubj which,inhibits
R13124 T15112 T15109 relcl inhibits,MKP-1
R13125 T15113 T15114 nummod p38,MAPK
R13126 T15114 T15112 dobj MAPK,inhibits
R13127 T15115 T15068 punct ",",provide
R13128 T15116 T15117 advmod thus,preventing
R13129 T15117 T15068 advcl preventing,provide
R13130 T15118 T15119 det the,phosphorylation
R13131 T15119 T15117 dobj phosphorylation,preventing
R13132 T15120 T15119 prep of,phosphorylation
R13133 T15121 T15120 pobj GATA-3,of
R13134 T15122 T15123 nsubj that,is
R13135 T15123 T15121 relcl is,GATA-3
R13136 T15124 T15123 acomp necessary,is
R13137 T15125 T15124 prep for,necessary
R13138 T15126 T15127 amod nuclear,translocation
R13139 T15127 T15125 pobj translocation,for
R13140 T15128 T15127 prep of,translocation
R13141 T15129 T15128 pobj GATA-3,of
R13142 T15130 T15068 punct .,provide
R13143 T15131 T15133 det These,mechanisms
R13144 T15132 T15133 nummod two,mechanisms
R13145 T15133 T15134 nsubj mechanisms,are
R13146 T15134 T15134 ROOT are,are
R13147 T15135 T15134 acomp likely,are
R13148 T15136 T15137 aux to,be
R13149 T15137 T15135 xcomp be,likely
R13150 T15138 T15137 acomp synergistic,be
R13151 T15139 T15137 punct ",",be
R13152 T15140 T15137 advcl accounting,be
R13153 T15141 T15140 prep for,accounting
R13154 T15142 T15146 det the,effect
R13155 T15143 T15146 amod rapid,effect
R13156 T15144 T15143 cc and,rapid
R13157 T15145 T15143 conj potent,rapid
R13158 T15146 T15141 pobj effect,for
R13159 T15147 T15146 prep of,effect
R13160 T15148 T15147 pobj corticosteroids,of
R13161 T15149 T15148 prep on,corticosteroids
R13162 T15150 T15151 amod allergic,inflammation
R13163 T15151 T15149 pobj inflammation,on
R13164 T15152 T15134 punct .,are
R13165 T15153 T15155 nsubjpass This,exemplified
R13166 T15154 T15155 auxpass is,exemplified
R13167 T15155 T15155 ROOT exemplified,exemplified
R13168 T15156 T15155 agent by,exemplified
R13169 T15157 T15160 det the,effect
R13170 T15158 T15160 amod rapid,effect
R13171 T15159 T15160 amod inhibitory,effect
R13172 T15160 T15156 pobj effect,by
R13173 T15161 T15160 prep of,effect
R13174 T15162 T15163 amod topical,corticosteroids
R13175 T15163 T15161 pobj corticosteroids,of
R13176 T15164 T15163 prep on,corticosteroids
R13177 T15165 T15168 amod nasal,release
R13178 T15166 T15168 amod Th2,release
R13179 T15167 T15168 compound cytokine,release
R13180 T15168 T15164 pobj release,on
R13181 T15169 T15155 prep after,exemplified
R13182 T15170 T15171 compound allergen,provocation
R13183 T15171 T15169 pobj provocation,after
R13184 T15172 T15171 prep in,provocation
R13185 T15173 T15172 pobj individuals,in
R13186 T15174 T15173 prep with,individuals
R13187 T15175 T15177 amod seasonal,rhinitis
R13188 T15176 T15177 amod allergic,rhinitis
R13189 T15177 T15174 pobj rhinitis,with
R13190 T15178 T15177 punct (,rhinitis
R13191 T15179 T15180 compound hay,fever
R13192 T15180 T15177 appos fever,rhinitis
R13193 T15181 T15177 punct ),rhinitis
R13194 T15182 T15184 quantmod [,]
R13195 T15183 T15184 nummod 43,]
R13196 T15184 T15173 appos ],individuals
R13197 T15185 T15155 punct .,exemplified
R13198 T15186 T15193 nsubj Prevention,provide
R13199 T15187 T15186 prep of,Prevention
R13200 T15188 T15189 amod phospho-GATA-3,interaction
R13201 T15189 T15187 pobj interaction,of
R13202 T15190 T15189 prep with,interaction
R13203 T15191 T15190 pobj importin-α,with
R13204 T15192 T15193 aux may,provide
R13205 T15193 T15193 ROOT provide,provide
R13206 T15194 T15196 det a,approach
R13207 T15195 T15196 amod new,approach
R13208 T15196 T15193 dobj approach,provide
R13209 T15197 T15196 prep for,approach
R13210 T15198 T15199 det the,development
R13211 T15199 T15197 pobj development,for
R13212 T15200 T15199 prep of,development
R13213 T15201 T15202 compound novel,therapies
R13214 T15202 T15200 pobj therapies,of
R13215 T15203 T15202 prep for,therapies
R13216 T15204 T15205 det the,treatment
R13217 T15205 T15203 pobj treatment,for
R13218 T15206 T15205 prep of,treatment
R13219 T15207 T15208 amod allergic,diseases
R13220 T15208 T15206 pobj diseases,of
R13221 T15209 T15193 punct .,provide
R12351 T14339 T14337 conj interacting,distinct
R12352 T14340 T14341 amod molecular,mechanisms
R12353 T14341 T14335 pobj mechanisms,via
R12354 T14342 T14312 punct .,demonstrated
R12355 T14343 T14347 advmod Firstly,appears
R12356 T14344 T14347 punct ",",appears
R12357 T14345 T14346 compound corticosteroid-activated,GR
R12358 T14346 T14347 nsubj GR,appears
R12359 T14347 T14347 ROOT appears,appears
R12360 T14348 T14349 aux to,compete
R12361 T14349 T14347 xcomp compete,appears
R12362 T14350 T14349 prep with,compete
R12363 T14351 T14352 amod activated,GATA-3
R12364 T14352 T14350 pobj GATA-3,with
R12365 T14353 T14349 prep for,compete
R12366 T14354 T14355 amod nuclear,import
R12367 T14355 T14353 pobj import,for
R12368 T14356 T14349 prep via,compete
R12369 T14357 T14356 pobj importin-α,via
R12370 T14358 T14357 punct ",",importin-α
R12371 T14359 T14361 nsubjpass which,required
R12372 T14360 T14361 auxpass is,required
R12373 T14361 T14349 advcl required,compete
R12374 T14362 T14361 prep for,required
R12375 T14363 T14365 det the,transport
R12376 T14364 T14365 amod nuclear,transport
R12377 T14365 T14362 pobj transport,for
R12378 T14366 T14365 prep of,transport
R12379 T14367 T14368 preconj both,GATA-3
R12380 T14368 T14366 pobj GATA-3,of
R12381 T14369 T14368 cc and,GATA-3
R12382 T14370 T14368 conj GR,GATA-3
R12383 T14371 T14347 punct .,appears
R12384 T14372 T14378 advmod Secondly,increase
R12385 T14373 T14378 punct ",",increase
R12386 T14374 T14378 nsubj corticosteroids,increase
R12387 T14375 T14374 prep at,corticosteroids
R12388 T14376 T14377 amod higher,concentrations
R12389 T14377 T14375 pobj concentrations,at
R12430 T14418 T14378 punct .,increase
R12431 T14419 T14422 nsubj We,shown
R12432 T14420 T14422 aux have,shown
R12433 T14421 T14422 advmod previously,shown
R12434 T14422 T14422 ROOT shown,shown
R12435 T14423 T14433 mark that,involves
R12436 T14424 T14433 nsubj translocation,involves
R12437 T14425 T14424 prep of,translocation
R12438 T14426 T14425 pobj GATA-3,of
R12439 T14427 T14424 prep from,translocation
R12440 T14428 T14429 det the,cytoplasm
R12441 T14429 T14427 pobj cytoplasm,from
R12442 T14430 T14424 prep to,translocation
R12443 T14431 T14432 det the,nucleus
R12444 T14432 T14430 pobj nucleus,to
R12445 T14433 T14422 ccomp involves,shown
R12446 T14434 T14437 det the,protein
R12447 T14435 T14436 amod nuclear,transporter
R12448 T14436 T14437 compound transporter,protein
R12449 T14437 T14438 compound protein,importin-α
R12450 T14438 T14433 dobj importin-α,involves
R12451 T14439 T14438 punct ",",importin-α
R12452 T14440 T14441 nsubj which,interacts
R12453 T14441 T14438 relcl interacts,importin-α
R12454 T14442 T14441 prep with,interacts
R12455 T14443 T14445 amod phosphorylated,[
R12456 T14444 T14445 compound GATA-3,[
R12457 T14445 T14442 pobj [,with
R12708 T14696 T14694 pobj synthesis,in
R12709 T14697 T14698 auxpass are,required
R12710 T14698 T14687 advcl required,be
R12711 T14699 T14677 punct .,is
R12712 T14700 T14702 det This,mechanism
R12713 T14701 T14702 amod acute,mechanism
R12714 T14702 T14705 nsubj mechanism,contribute
R12715 T14703 T14705 aux may,contribute
R12716 T14704 T14705 advmod also,contribute
R12717 T14705 T14705 ROOT contribute,contribute
R12718 T14706 T14705 prep to,contribute
R12719 T14707 T14708 det the,reduction
R12720 T14708 T14706 pobj reduction,to
R12721 T14709 T14708 prep in,reduction
R12722 T14710 T14712 amod GATA-3,import
R12723 T14711 T14712 amod nuclear,import
R12724 T14712 T14709 pobj import,in
R12725 T14713 T14705 cc and,contribute
R12726 T14714 T14715 aux may,play
R12727 T14715 T14705 conj play,contribute
R12728 T14716 T14718 det a,role
R12729 T14717 T14718 amod major,role
R12730 T14718 T14715 dobj role,play
R12731 T14719 T14715 prep at,play
R12732 T14720 T14722 amod low,concentrations
R12733 T14721 T14722 amod corticosteroid,concentrations
R12734 T14722 T14719 pobj concentrations,at
R12735 T14723 T14719 cc and/or,at
R12736 T14724 T14719 conj at,at
R12737 T14725 T14726 amod early,time
R12738 T14726 T14724 pobj time,at
R12739 T14727 T14728 compound points,prior
R12740 T14728 T14715 advmod prior,play

UBERON-AE

Id Subject Object Predicate Lexical cue
T13159 4481-4486 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GO-BP

Id Subject Object Predicate Lexical cue
T15238 142-155 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15239 1109-1122 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15240 1575-1588 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15241 3789-3802 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15242 306-320 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15243 706-720 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15244 1205-1219 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15245 1344-1358 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15246 2497-2511 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15247 2955-2969 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15248 3408-3422 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15249 4762-4776 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15250 363-380 http://purl.obolibrary.org/obo/GO_0051169 denotes nuclear transport
T15251 371-380 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T15252 511-514 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15253 591-594 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15254 2658-2661 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15255 2985-2988 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15256 3156-3159 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15257 3312-3315 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15258 515-519 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15259 595-599 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15260 2662-2666 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15261 2741-2745 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15262 2989-2993 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15263 3160-3164 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15264 3316-3320 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15265 4881-4885 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15266 577-599 http://purl.obolibrary.org/obo/GO_1900745 denotes activation of p38 MAPK
T15267 615-630 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15268 3025-3040 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15269 4907-4922 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15270 1414-1435 http://purl.obolibrary.org/obo/GO_0005049 denotes binding of importin-α
T15271 1934-1948 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T15272 1976-1987 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T15273 2397-2414 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T15274 2405-2414 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T15275 4842-4851 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T15276 3517-3529 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15277 4645-4657 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15278 5113-5125 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15279 4770-4784 http://purl.obolibrary.org/obo/GO_0017038 denotes import protein
T15280 5419-5430 http://purl.obolibrary.org/obo/GO_0032502 denotes development

GO-MF

Id Subject Object Predicate Lexical cue
T15296 595-599 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15297 2662-2666 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15298 2741-2745 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15299 2989-2993 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15300 3160-3164 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15301 3316-3320 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15302 4881-4885 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15303 1030-1034 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15304 3613-3617 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15305 3784-3788 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15306 4443-4447 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15307 1035-1039 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T15308 4452-4456 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T15309 1301-1307 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T15310 1414-1421 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15311 4740-4747 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15312 1414-1435 http://purl.obolibrary.org/obo/GO_0005049 denotes binding of importin-α
T15289 511-514 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15290 591-594 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15291 2658-2661 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15292 2985-2988 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15293 3156-3159 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15294 3312-3315 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15295 515-519 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

GO-CC

Id Subject Object Predicate Lexical cue
T15313 551-555 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T15314 1171-1176 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15315 2838-2843 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15316 4119-4124 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15317 4487-4492 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15318 785-794 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T15319 802-809 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus

sentences

Id Subject Object Predicate Lexical cue
T13323 11-223 Sentence denotes Here we have demonstrated, to our knowledge for the first time, that corticosteroids may inhibit GATA-3 function and therefore the transcription of Th2 genes via two distinct but interacting molecular mechanisms.
T13324 224-403 Sentence denotes Firstly, corticosteroid-activated GR appears to compete with activated GATA-3 for nuclear import via importin-α, which is required for the nuclear transport of both GATA-3 and GR.
T13325 404-721 Sentence denotes Secondly, corticosteroids at higher concentrations increase the expression of MKP-1, a potent inhibitor of p38 MAPK activity and thereby prevent T cell receptor/co-receptor activation of p38 MAPK to prevent the phosphorylation of GATA-3 that is necessary for interaction with importin-α and subsequent nuclear import.
T13326 722-911 Sentence denotes We have previously shown that translocation of GATA-3 from the cytoplasm to the nucleus involves the nuclear transporter protein importin-α, which interacts with phosphorylated GATA-3 [12].
T13327 912-1143 Sentence denotes We have also previously reported that GATA-3 knockdown using siRNA results in suppression of anti-CD3/CD28–stimulated IL-4/IL-5 mRNA induction, thus implicating an essential role for GATA-3 in the transcription of these genes [12].
T13328 1144-1245 Sentence denotes We now confirm, in human T cells, that GR also uses the same nuclear import mechanism as GATA-3 [22].
T13329 1246-1359 Sentence denotes We therefore propose that there is competition between ligand-activated GR and phospho-GATA-3 for nuclear import.
T13330 1360-1633 Sentence denotes Furthermore, we have shown that there is preferential binding of importin-α to activated GR over phospho-GATA-3, so that corticosteroids would preferentially reduce GATA-3 entry and thus rapidly switch off Th2 gene transcription without any need for any intermediate steps.
T13331 1634-1793 Sentence denotes Furthermore, there was some degree of specificity for GATA-3, as nuclear translocation of the p65 subunit of NF-κB was not affected by corticosteroid exposure.
T13332 1794-1988 Sentence denotes We tested some alternative explanations for this effect of FP on GATA-3 nuclear exclusion and failed to show that FP either enhances GATA-3 nuclear export directly or induces GATA-3 degradation.
T13333 1989-2195 Sentence denotes The evidence from the in vitro competition assays does, however, suggest that purified activated GR can clearly attenuate purified phospho-GATA-3–importin-α association and that the converse does not occur.
T13334 2196-2278 Sentence denotes Furthermore, we have shown that only phospho-GATA-3 can associate with importin-α.
T13335 2279-2428 Sentence denotes This mechanism is sensitive to very low concentrations of corticosteroid and would be rapid in onset as no changes in protein synthesis are required.
T13336 2429-2628 Sentence denotes This acute mechanism may also contribute to the reduction in GATA-3 nuclear import and may play a major role at low corticosteroid concentrations and/or at early time points prior to MKP-1 induction.
T13337 2629-2765 Sentence denotes Corticosteroids can modulate p38 MAPK activity through the induction of MKP-1, a potent endogenous inhibitor of MAPK function [38],[39].
T13338 2766-2886 Sentence denotes We report here a rapid induction of MKP-1 mRNA following stimulation of cells with relatively high concentrations of FP.
T13339 2887-3080 Sentence denotes We hypothesize that this rapid induction of MKP-1 can reduce GATA-3 nuclear import by attenuating p38 MAPK activity and subsequent GATA-3 phosphorylation, thus preventing nuclear translocation.
T13340 3081-3347 Sentence denotes The location of the serine residue(s) of GATA-3 that are phosphorylated by p38 MAPK are currently unknown, but a bioinformatics search (Motif Scanner, http://scansite.mit.edu/motifscan_seq.phtml) indicates at least three potential p38 MAPK-sensitive serine residues.
T13341 3348-3530 Sentence denotes As predicted from these in vitro data, impairment of GATA-3 nuclear import by FP may, at least in part, underlie the efficacy of corticosteroids in suppressing allergic inflammation.
T13342 3531-3831 Sentence denotes Although we did not assess the acute inhibitory effect of FP on the expression of IL-4 mRNA in vivo, a single inhalation of FP (500 µg) may have comparable effects, as it provides plasma levels within a relevant range of concentrations used to suppress IL-4 transcription in our in vitro system [37].
T13343 3832-3963 Sentence denotes A lower dose of inhaled FP (100 µg) was not effective, but plasma concentrations may be below those required for GATA-3 inhibition.
T13344 3964-4144 Sentence denotes However, it is likely that the higher concentrations of FP in the airways after inhaled administration would be effective in inhibiting GATA-3 in airway T cells of asthma patients.
T13345 4145-4367 Sentence denotes The study of PBMCs from asthma patients treated with inhaled corticosteroid therapy clearly demonstrates that these molecular mechanisms are likely to also occur in patients at therapeutic doses of inhaled corticosteroids.
T13346 4368-4543 Sentence denotes In addition, previous studies have shown that corticosteroids can suppress IL-4 and IL-5 release from peripheral blood cells of asthma patients in vitro and in vivo [40]–[42].
T13347 4544-4987 Sentence denotes In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3.
T13348 4988-5126 Sentence denotes These two mechanisms are likely to be synergistic, accounting for the rapid and potent effect of corticosteroids on allergic inflammation.
T13349 5127-5326 Sentence denotes This is exemplified by the rapid inhibitory effect of topical corticosteroids on nasal Th2 cytokine release after allergen provocation in individuals with seasonal allergic rhinitis (hay fever) [43].
T13350 5327-5489 Sentence denotes Prevention of phospho-GATA-3 interaction with importin-α may provide a new approach for the development of novel therapies for the treatment of allergic diseases.
T261 0-10 Sentence denotes Discussion
T262 11-223 Sentence denotes Here we have demonstrated, to our knowledge for the first time, that corticosteroids may inhibit GATA-3 function and therefore the transcription of Th2 genes via two distinct but interacting molecular mechanisms.
T263 224-403 Sentence denotes Firstly, corticosteroid-activated GR appears to compete with activated GATA-3 for nuclear import via importin-α, which is required for the nuclear transport of both GATA-3 and GR.
T264 404-721 Sentence denotes Secondly, corticosteroids at higher concentrations increase the expression of MKP-1, a potent inhibitor of p38 MAPK activity and thereby prevent T cell receptor/co-receptor activation of p38 MAPK to prevent the phosphorylation of GATA-3 that is necessary for interaction with importin-α and subsequent nuclear import.
T265 722-911 Sentence denotes We have previously shown that translocation of GATA-3 from the cytoplasm to the nucleus involves the nuclear transporter protein importin-α, which interacts with phosphorylated GATA-3 [12].
T266 912-1143 Sentence denotes We have also previously reported that GATA-3 knockdown using siRNA results in suppression of anti-CD3/CD28–stimulated IL-4/IL-5 mRNA induction, thus implicating an essential role for GATA-3 in the transcription of these genes [12].
T267 1144-1245 Sentence denotes We now confirm, in human T cells, that GR also uses the same nuclear import mechanism as GATA-3 [22].
T268 1246-1359 Sentence denotes We therefore propose that there is competition between ligand-activated GR and phospho-GATA-3 for nuclear import.
T269 1360-1633 Sentence denotes Furthermore, we have shown that there is preferential binding of importin-α to activated GR over phospho-GATA-3, so that corticosteroids would preferentially reduce GATA-3 entry and thus rapidly switch off Th2 gene transcription without any need for any intermediate steps.
T270 1634-1793 Sentence denotes Furthermore, there was some degree of specificity for GATA-3, as nuclear translocation of the p65 subunit of NF-κB was not affected by corticosteroid exposure.
T271 1794-1988 Sentence denotes We tested some alternative explanations for this effect of FP on GATA-3 nuclear exclusion and failed to show that FP either enhances GATA-3 nuclear export directly or induces GATA-3 degradation.
T272 1989-2195 Sentence denotes The evidence from the in vitro competition assays does, however, suggest that purified activated GR can clearly attenuate purified phospho-GATA-3–importin-α association and that the converse does not occur.
T273 2196-2278 Sentence denotes Furthermore, we have shown that only phospho-GATA-3 can associate with importin-α.
T274 2279-2428 Sentence denotes This mechanism is sensitive to very low concentrations of corticosteroid and would be rapid in onset as no changes in protein synthesis are required.
T275 2429-2628 Sentence denotes This acute mechanism may also contribute to the reduction in GATA-3 nuclear import and may play a major role at low corticosteroid concentrations and/or at early time points prior to MKP-1 induction.
T276 2629-2765 Sentence denotes Corticosteroids can modulate p38 MAPK activity through the induction of MKP-1, a potent endogenous inhibitor of MAPK function [38],[39].
T277 2766-2886 Sentence denotes We report here a rapid induction of MKP-1 mRNA following stimulation of cells with relatively high concentrations of FP.
T278 2887-3080 Sentence denotes We hypothesize that this rapid induction of MKP-1 can reduce GATA-3 nuclear import by attenuating p38 MAPK activity and subsequent GATA-3 phosphorylation, thus preventing nuclear translocation.
T279 3081-3347 Sentence denotes The location of the serine residue(s) of GATA-3 that are phosphorylated by p38 MAPK are currently unknown, but a bioinformatics search (Motif Scanner, http://scansite.mit.edu/motifscan_seq.phtml) indicates at least three potential p38 MAPK-sensitive serine residues.
T280 3348-3530 Sentence denotes As predicted from these in vitro data, impairment of GATA-3 nuclear import by FP may, at least in part, underlie the efficacy of corticosteroids in suppressing allergic inflammation.
T281 3531-3831 Sentence denotes Although we did not assess the acute inhibitory effect of FP on the expression of IL-4 mRNA in vivo, a single inhalation of FP (500 µg) may have comparable effects, as it provides plasma levels within a relevant range of concentrations used to suppress IL-4 transcription in our in vitro system [37].
T282 3832-3963 Sentence denotes A lower dose of inhaled FP (100 µg) was not effective, but plasma concentrations may be below those required for GATA-3 inhibition.
T283 3964-4144 Sentence denotes However, it is likely that the higher concentrations of FP in the airways after inhaled administration would be effective in inhibiting GATA-3 in airway T cells of asthma patients.
T284 4145-4367 Sentence denotes The study of PBMCs from asthma patients treated with inhaled corticosteroid therapy clearly demonstrates that these molecular mechanisms are likely to also occur in patients at therapeutic doses of inhaled corticosteroids.
T285 4368-4543 Sentence denotes In addition, previous studies have shown that corticosteroids can suppress IL-4 and IL-5 release from peripheral blood cells of asthma patients in vitro and in vivo [40]–[42].
T286 4544-4987 Sentence denotes In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3.
T287 4988-5126 Sentence denotes These two mechanisms are likely to be synergistic, accounting for the rapid and potent effect of corticosteroids on allergic inflammation.
T288 5127-5326 Sentence denotes This is exemplified by the rapid inhibitory effect of topical corticosteroids on nasal Th2 cytokine release after allergen provocation in individuals with seasonal allergic rhinitis (hay fever) [43].
T289 5327-5489 Sentence denotes Prevention of phospho-GATA-3 interaction with importin-α may provide a new approach for the development of novel therapies for the treatment of allergic diseases.

ICD10

Id Subject Object Predicate Lexical cue
T15281 4128-4134 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T15282 4169-4175 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T15283 4496-4502 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T15284 4128-4134 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T15285 4169-4175 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T15286 4496-4502 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T15287 5291-5308 http://purl.bioontology.org/ontology/ICD10/J30.4 denotes allergic rhinitis
T15288 5314-5319 http://purl.bioontology.org/ontology/ICD10/R50.9 denotes fever

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T15783 108-114 Protein denotes GATA-3
T15784 248-257 Positive_regulation denotes activated
T15785 258-260 Protein denotes GR
T15786 272-279 Negative_regulation denotes compete
T15787 285-294 Positive_regulation denotes activated
T15788 295-301 Protein denotes GATA-3
T15789 306-313 Entity denotes nuclear
T15790 314-320 Localization denotes import
T15791 321-324 Regulation denotes via
T15792 346-354 Regulation denotes required
T15793 346-354 Regulation denotes required
T15794 363-370 Entity denotes nuclear
T15795 371-380 Localization denotes transport
T15796 371-380 Localization denotes transport
T15797 389-395 Protein denotes GATA-3
T15798 400-402 Protein denotes GR
T15799 455-463 Positive_regulation denotes increase
T15800 468-478 Gene_expression denotes expression
T15801 482-487 Protein denotes MKP-1
T15802 603-610 Negative_regulation denotes prevent
T15803 615-630 Phosphorylation denotes phosphorylation
T15804 634-640 Protein denotes GATA-3
T15805 649-658 Positive_regulation denotes necessary
T15806 649-658 Positive_regulation denotes necessary
T15807 663-674 Binding denotes interaction
T15808 695-705 Positive_regulation denotes subsequent
T15809 706-713 Entity denotes nuclear
T15810 714-720 Localization denotes import
T15811 752-765 Localization denotes translocation
T15812 769-775 Protein denotes GATA-3
T15813 802-809 Entity denotes nucleus
T15814 810-818 Regulation denotes involves
T15815 869-878 Binding denotes interacts
T15816 884-898 Phosphorylation denotes phosphorylated
T15817 899-905 Protein denotes GATA-3
T15818 950-956 Protein denotes GATA-3
T15819 957-966 Gene_expression denotes knockdown true
T15820 990-1001 Negative_regulation denotes suppression
T15821 990-1001 Negative_regulation denotes suppression
T15822 1019-1029 Positive_regulation denotes stimulated
T15823 1019-1029 Positive_regulation denotes stimulated
T15824 1030-1034 Protein denotes IL-4
T15825 1035-1039 Protein denotes IL-5
T15826 1045-1054 Transcription denotes induction
T15827 1045-1054 Transcription denotes induction
T15828 1086-1090 Regulation denotes role
T15829 1086-1090 Regulation denotes role
T15830 1095-1101 Protein denotes GATA-3
T15831 1109-1122 Transcription denotes transcription
T15832 1109-1122 Transcription denotes transcription
T15833 1183-1185 Protein denotes GR
T15834 1205-1212 Entity denotes nuclear
T15835 1213-1219 Localization denotes import
T15836 1233-1239 Protein denotes GATA-3
T15837 1281-1292 Negative_regulation denotes competition true
T15838 1318-1320 Protein denotes GR
T15839 1325-1332 Phosphorylation denotes phospho
T15840 1333-1339 Protein denotes GATA-3
T15841 1344-1351 Entity denotes nuclear
T15842 1352-1358 Localization denotes import
T15843 1414-1421 Binding denotes binding
T15844 1414-1421 Binding denotes binding
T15845 1439-1448 Positive_regulation denotes activated
T15846 1449-1451 Protein denotes GR
T15847 1457-1464 Phosphorylation denotes phospho
T15848 1465-1471 Protein denotes GATA-3
T15849 1518-1524 Negative_regulation denotes reduce true
T15850 1525-1531 Protein denotes GATA-3
T15851 1532-1537 Localization denotes entry
T15852 1688-1694 Protein denotes GATA-3
T15853 1699-1706 Entity denotes nuclear
T15854 1707-1720 Localization denotes translocation
T15855 1728-1731 Protein denotes p65
T15856 1757-1765 Regulation denotes affected true
T15857 1838-1849 Negative_regulation denotes this effect
T15858 1859-1865 Protein denotes GATA-3
T15859 1866-1873 Entity denotes nuclear
T15860 1874-1883 Localization denotes exclusion
T15861 1918-1926 Positive_regulation denotes enhances true
T15862 1927-1933 Protein denotes GATA-3
T15863 1934-1941 Entity denotes nuclear
T15864 1942-1948 Localization denotes export
T15865 1961-1968 Positive_regulation denotes induces true
T15866 1969-1975 Protein denotes GATA-3
T15867 1976-1987 Protein_catabolism denotes degradation
T15868 2076-2085 Positive_regulation denotes activated
T15869 2086-2088 Protein denotes GR
T15870 2101-2110 Negative_regulation denotes attenuate
T15871 2120-2127 Phosphorylation denotes phospho
T15872 2128-2134 Protein denotes GATA-3
T15873 2146-2157 Binding denotes association
T15874 2233-2240 Phosphorylation denotes phospho
T15875 2241-2247 Protein denotes GATA-3
T15876 2252-2261 Binding denotes associate
T15877 2459-2469 Positive_regulation denotes contribute true
T15878 2477-2486 Negative_regulation denotes reduction
T15879 2490-2496 Protein denotes GATA-3
T15880 2497-2504 Entity denotes nuclear
T15881 2505-2511 Localization denotes import
T15882 2533-2537 Regulation denotes role true
T15883 2612-2617 Protein denotes MKP-1
T15884 2618-2627 Gene_expression denotes induction
T15885 2688-2697 Positive_regulation denotes induction
T15886 2701-2706 Protein denotes MKP-1
T15887 2789-2798 Gene_expression denotes induction
T15888 2802-2807 Protein denotes MKP-1
T15889 2813-2822 Positive_regulation denotes following
T15890 2918-2927 Gene_expression denotes induction
T15891 2931-2936 Protein denotes MKP-1
T15892 2941-2947 Negative_regulation denotes reduce
T15893 2948-2954 Protein denotes GATA-3
T15894 2955-2962 Entity denotes nuclear
T15895 2963-2969 Localization denotes import
T15896 2973-2984 Negative_regulation denotes attenuating
T15897 3007-3017 Regulation denotes subsequent
T15898 3018-3024 Protein denotes GATA-3
T15899 3025-3040 Phosphorylation denotes phosphorylation
T15900 3047-3057 Negative_regulation denotes preventing true
T15901 3058-3065 Entity denotes nuclear
T15902 3066-3079 Localization denotes translocation
T15903 3101-3115 Entity denotes serine residue
T15904 3122-3128 Protein denotes GATA-3
T15905 3138-3152 Phosphorylation denotes phosphorylated
T15906 3387-3397 Negative_regulation denotes impairment
T15907 3401-3407 Protein denotes GATA-3
T15908 3408-3415 Entity denotes nuclear
T15909 3416-3422 Localization denotes import
T15910 3568-3585 Negative_regulation denotes inhibitory effect true true
T15911 3599-3609 Transcription denotes expression
T15912 3613-3617 Protein denotes IL-4
T15913 3775-3783 Negative_regulation denotes suppress
T15914 3784-3788 Protein denotes IL-4
T15915 3789-3802 Transcription denotes transcription
T15916 3945-3951 Protein denotes GATA-3
T15917 3952-3962 Negative_regulation denotes inhibition
T15918 4089-4099 Negative_regulation denotes inhibiting
T15919 4100-4106 Protein denotes GATA-3
T15920 4434-4442 Negative_regulation denotes suppress
T15921 4434-4442 Negative_regulation denotes suppress
T15922 4443-4447 Protein denotes IL-4
T15923 4452-4456 Protein denotes IL-5
T15924 4457-4464 Localization denotes release
T15925 4457-4464 Localization denotes release
T15926 4674-4691 Negative_regulation denotes inhibitory effect
T15927 4674-4691 Negative_regulation denotes inhibitory effect
T15928 4695-4701 Protein denotes GATA-3
T15929 4702-4709 Entity denotes nuclear
T15930 4710-4723 Localization denotes translocation
T15931 4740-4747 Binding denotes binding
T15932 4832-4841 Positive_regulation denotes increased
T15933 4842-4851 Gene_expression denotes synthesis
T15934 4855-4860 Protein denotes MKP-1
T15935 4892-4902 Negative_regulation denotes preventing
T15936 4907-4922 Phosphorylation denotes phosphorylation
T15937 4926-4932 Protein denotes GATA-3
T15938 4941-4950 Positive_regulation denotes necessary
T15939 4955-4962 Entity denotes nuclear
T15940 4963-4976 Localization denotes translocation
T15941 4980-4986 Protein denotes GATA-3
T15942 5327-5337 Negative_regulation denotes Prevention
T15943 5341-5348 Phosphorylation denotes phospho
T15944 5349-5355 Protein denotes GATA-3
T15945 5356-5367 Binding denotes interaction
R13552 T15785 T15784 themeOf GR,activated
R13553 T15785 T15786 causeOf GR,compete
R13555 T15788 T15786 themeOf GATA-3,compete
R13558 T15788 T15787 themeOf GATA-3,activated
R13559 T15788 T15790 themeOf GATA-3,import
R13560 T15789 T15790 locationOf nuclear,import
R13562 T15790 T15791 themeOf import,via
R13564 T15794 T15796 locationOf nuclear,transport
R13565 T15794 T15795 locationOf nuclear,transport
R13566 T15795 T15792 themeOf transport,required
R13568 T15796 T15793 themeOf transport,required
R13569 T15797 T15796 themeOf GATA-3,transport
R13570 T15798 T15795 themeOf GR,transport
R13572 T15800 T15799 themeOf expression,increase
R13573 T15801 T15800 themeOf MKP-1,expression
R13576 T15803 T15802 themeOf phosphorylation,prevent
R13577 T15803 T15805 causeOf phosphorylation,necessary
R13578 T15803 T15806 causeOf phosphorylation,necessary
R13579 T15804 T15803 themeOf GATA-3,phosphorylation
R13580 T15804 T15807 themeOf GATA-3,interaction
R13581 T15804 T15810 themeOf GATA-3,import
R13583 T15807 T15805 themeOf interaction,necessary
R13584 T15807 T15808 causeOf interaction,subsequent
R13585 T15809 T15810 locationOf nuclear,import
R13587 T15810 T15806 themeOf import,necessary
R13588 T15810 T15808 themeOf import,subsequent
R13589 T15811 T15814 themeOf translocation,involves
R13590 T15812 T15811 themeOf GATA-3,translocation
R13591 T15813 T15811 locationOf nucleus,translocation
R13592 T15817 T15815 themeOf GATA-3,interacts
R13593 T15817 T15816 themeOf GATA-3,phosphorylated
R13594 T15818 T15819 themeOf GATA-3,knockdown
R13596 T15819 T15820 causeOf knockdown,suppression
R13597 T15819 T15821 causeOf knockdown,suppression
R13598 T15822 T15821 themeOf stimulated,suppression
R13600 T15823 T15820 themeOf stimulated,suppression
R13601 T15824 T15826 themeOf IL-4,induction
R13602 T15824 T15832 themeOf IL-4,transcription
R13603 T15825 T15827 themeOf IL-5,induction
R13604 T15825 T15831 themeOf IL-5,transcription
R13606 T15826 T15823 themeOf induction,stimulated
R13607 T15827 T15822 themeOf induction,stimulated
R13609 T15830 T15829 causeOf GATA-3,role
R13610 T15830 T15828 causeOf GATA-3,role
R13611 T15831 T15828 themeOf transcription,role
R13612 T15832 T15829 themeOf transcription,role
R13613 T15833 T15835 themeOf GR,import
R13614 T15834 T15835 locationOf nuclear,import
R13616 T15838 T15837 causeOf GR,competition
R13618 T15840 T15842 themeOf GATA-3,import
R13619 T15840 T15839 themeOf GATA-3,phospho
R13620 T15841 T15842 locationOf nuclear,import
R13621 T15842 T15837 themeOf import,competition
R13622 T15883 T15884 themeOf MKP-1,induction
R13623 T15846 T15843 themeOf GR,binding
R13624 T15846 T15845 themeOf GR,activated
R13625 T15848 T15844 themeOf GATA-3,binding
R13626 T15848 T15847 themeOf GATA-3,phospho
R13627 T15850 T15851 themeOf GATA-3,entry
R13628 T15884 T15882 themeOf induction,role
R13629 T15851 T15849 themeOf entry,reduce
R13630 T15853 T15854 locationOf nuclear,translocation
R13631 T15886 T15885 themeOf MKP-1,induction
R13632 T15854 T15856 themeOf translocation,affected
R13633 T15855 T15854 themeOf p65,translocation
R13634 T15858 T15860 themeOf GATA-3,exclusion
R13635 T15887 T15889 themeOf induction,following
R13636 T15859 T15860 locationOf nuclear,exclusion
R13637 T15860 T15857 themeOf exclusion,this effect
R13638 T15888 T15887 themeOf MKP-1,induction
R13639 T15862 T15864 themeOf GATA-3,export
R13640 T15863 T15864 locationOf nuclear,export
R13641 T15864 T15861 themeOf export,enhances
R13642 T15866 T15867 themeOf GATA-3,degradation
R13643 T15890 T15896 causeOf induction,attenuating
R13644 T15867 T15865 themeOf degradation,induces
R13645 T15869 T15868 themeOf GR,activated
R13646 T15869 T15870 causeOf GR,attenuate
R13647 T15891 T15890 themeOf MKP-1,induction
R13648 T15872 T15873 themeOf GATA-3,association
R13649 T15872 T15871 themeOf GATA-3,phospho
R13650 T15873 T15870 themeOf association,attenuate
R13651 T15893 T15902 themeOf GATA-3,translocation
R13652 T15875 T15874 themeOf GATA-3,phospho
R13653 T15875 T15876 themeOf GATA-3,associate
R13654 T15878 T15877 themeOf reduction,contribute
R13655 T15879 T15881 themeOf GATA-3,import
R13656 T15880 T15881 locationOf nuclear,import
R13657 T15893 T15895 themeOf GATA-3,import
R13658 T15881 T15878 themeOf import,reduction
R13659 T15894 T15895 locationOf nuclear,import
R13660 T15895 T15892 themeOf import,reduce
R13661 T15896 T15900 causeOf attenuating,preventing
R13662 T15896 T15892 causeOf attenuating,reduce
R13663 T15897 T15896 themeOf subsequent,attenuating
R13664 T15898 T15899 themeOf GATA-3,phosphorylation
R13665 T15899 T15897 themeOf phosphorylation,subsequent
R13666 T15901 T15902 locationOf nuclear,translocation
R13667 T15902 T15900 themeOf translocation,preventing
R13668 T15903 T15905 themeOf serine residue,phosphorylated
R13669 T15903 T15904 partOf serine residue,GATA-3
R13670 T15907 T15909 themeOf GATA-3,import
R13671 T15908 T15909 locationOf nuclear,import
R13672 T15909 T15906 themeOf import,impairment
R13673 T15911 T15910 themeOf expression,inhibitory effect
R13674 T15912 T15911 themeOf IL-4,expression
R13675 T15914 T15915 themeOf IL-4,transcription
R13676 T15915 T15913 themeOf transcription,suppress
R13677 T15916 T15917 themeOf GATA-3,inhibition
R13678 T15919 T15918 themeOf GATA-3,inhibiting
R13679 T15922 T15924 themeOf IL-4,release
R13680 T15923 T15925 themeOf IL-5,release
R13681 T15924 T15921 themeOf release,suppress
R13682 T15925 T15920 themeOf release,suppress
R13683 T15928 T15930 themeOf GATA-3,translocation
R13684 T15928 T15931 themeOf GATA-3,binding
R13685 T15929 T15930 locationOf nuclear,translocation
R13686 T15930 T15927 themeOf translocation,inhibitory effect
R13687 T15930 T15926 themeOf translocation,inhibitory effect
R13688 T15931 T15927 causeOf binding,inhibitory effect
R13689 T15932 T15926 causeOf increased,inhibitory effect
R13690 T15932 T15935 causeOf increased,preventing
R13691 T15933 T15932 themeOf synthesis,increased
R13692 T15934 T15933 themeOf MKP-1,synthesis
R13693 T15936 T15935 themeOf phosphorylation,preventing
R13694 T15937 T15936 themeOf GATA-3,phosphorylation
R13695 T15939 T15940 locationOf nuclear,translocation
R13696 T15940 T15938 themeOf translocation,necessary
R13697 T15941 T15940 themeOf GATA-3,translocation
R13698 T15944 T15945 themeOf GATA-3,interaction
R13699 T15944 T15943 themeOf GATA-3,phospho
R13700 T15945 T15942 themeOf interaction,Prevention

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T15646 108-114 Protein denotes GATA-3
T15647 159-168 Protein denotes Th2 genes
T15648 142-155 Transcription denotes transcription
T15649 258-260 Protein denotes GR
T15650 295-301 Protein denotes GATA-3
T15651 389-395 Protein denotes GATA-3
T15652 400-402 Protein denotes GR
T15653 272-279 Binding denotes compete
T15654 285-294 Positive_regulation denotes activated
T15655 306-313 Entity denotes nuclear
T15656 363-370 Entity denotes nuclear
T15657 371-380 Localization denotes transport
T15658 371-380 Localization denotes transport
T15659 346-354 Positive_regulation denotes required
T15660 346-354 Positive_regulation denotes required
T15661 482-487 Protein denotes MKP-1
T15662 511-519 Protein denotes p38 MAPK
T15663 549-576 Protein denotes T cell receptor/co-receptor
T15664 591-599 Protein denotes p38 MAPK
T15665 634-640 Protein denotes GATA-3
T15666 680-690 Protein denotes importin-α
T15667 468-478 Gene_expression denotes expression
T15668 498-507 Negative_regulation denotes inhibitor
T15669 577-587 Positive_regulation denotes activation
T15670 615-630 Phosphorylation denotes phosphorylation
T15671 663-674 Binding denotes interaction
T15672 706-713 Entity denotes nuclear
T15673 714-720 Localization denotes import
T15674 455-463 Positive_regulation denotes increase
T15675 541-548 Negative_regulation denotes prevent
T15676 603-610 Negative_regulation denotes prevent
T15677 649-658 Positive_regulation denotes necessary
T15678 769-775 Protein denotes GATA-3
T15679 823-861 Protein denotes nuclear transporter protein importin-α
T15680 802-809 Entity denotes nucleus
T15681 869-878 Binding denotes interacts
T15682 752-765 Localization denotes translocation
T15683 950-956 Protein denotes GATA-3
T15684 1010-1013 Protein denotes CD3
T15685 1014-1018 Protein denotes CD28
T15686 1030-1044 Protein denotes IL-4/IL-5 mRNA
T15687 1095-1101 Protein denotes GATA-3
T15688 957-966 Negative_regulation denotes knockdown
T15689 1109-1122 Transcription denotes transcription
T15690 1183-1185 Protein denotes GR
T15691 1318-1320 Protein denotes GR
T15692 1425-1435 Protein denotes importin-α
T15693 1449-1451 Protein denotes GR
T15694 1566-1574 Protein denotes Th2 gene
T15695 1414-1421 Binding denotes binding
T15696 1414-1421 Binding denotes binding
T15697 1439-1448 Positive_regulation denotes activated
T15698 1439-1448 Positive_regulation denotes activated
T15699 1439-1448 Positive_regulation denotes activated
T15700 1575-1588 Transcription denotes transcription
T15701 1555-1561 Negative_regulation denotes switch
T15702 1555-1561 Positive_regulation denotes switch
T15703 1688-1694 Protein denotes GATA-3
T15704 1728-1739 Protein denotes p65 subunit
T15705 1743-1748 Protein denotes NF-κB
T15706 1699-1706 Entity denotes nuclear
T15707 1707-1720 Localization denotes translocation
T15708 1707-1720 Localization denotes translocation
T15709 1757-1765 Regulation denotes affected
T15710 1757-1765 Regulation denotes affected
T15711 1853-1855 Protein denotes FP
T15712 1859-1865 Protein denotes GATA-3
T15713 1969-1975 Protein denotes GATA-3
T15714 1866-1873 Entity denotes nuclear
T15715 1874-1883 Localization denotes exclusion
T15716 1976-1987 Protein_catabolism denotes degradation
T15717 1961-1968 Positive_regulation denotes induces
T15718 2086-2088 Protein denotes GR
T15719 2076-2085 Positive_regulation denotes activated
T15720 2267-2277 Protein denotes importin-α
T15721 2252-2261 Binding denotes associate
T15722 2612-2617 Protein denotes MKP-1
T15723 2618-2627 Positive_regulation denotes induction
T15724 2658-2666 Protein denotes p38 MAPK
T15725 2701-2706 Protein denotes MKP-1
T15726 2741-2745 Protein denotes MAPK
T15727 2688-2697 Positive_regulation denotes induction
T15728 2728-2737 Negative_regulation denotes inhibitor
T15729 2649-2657 Regulation denotes modulate
T15730 2688-2697 Positive_regulation denotes induction
T15731 2802-2812 Protein denotes MKP-1 mRNA
T15732 2883-2885 Protein denotes FP
T15733 2789-2798 Positive_regulation denotes induction
T15734 2931-2936 Protein denotes MKP-1
T15735 2985-2993 Protein denotes p38 MAPK
T15736 2918-2927 Positive_regulation denotes induction
T15737 2955-2962 Entity denotes nuclear
T15738 2973-2984 Positive_regulation denotes attenuating
T15739 3025-3040 Phosphorylation denotes phosphorylation
T15740 3058-3065 Entity denotes nuclear
T15741 2973-2984 Positive_regulation denotes attenuating
T15742 3122-3128 Protein denotes GATA-3
T15743 3156-3164 Protein denotes p38 MAPK
T15744 3312-3315 Protein denotes p38
T15745 3138-3152 Phosphorylation denotes phosphorylated
T15746 3426-3428 Protein denotes FP
T15747 3613-3622 Protein denotes IL-4 mRNA
T15748 3784-3788 Protein denotes IL-4
T15749 3599-3609 Gene_expression denotes expression
T15750 3789-3802 Transcription denotes transcription
T15751 3579-3585 Regulation denotes effect
T15752 3775-3783 Negative_regulation denotes suppress
T15753 3945-3951 Protein denotes GATA-3
T15754 3952-3962 Negative_regulation denotes inhibition
T15755 4020-4022 Protein denotes FP
T15756 4100-4106 Protein denotes GATA-3
T15757 4089-4099 Negative_regulation denotes inhibiting
T15758 4443-4447 Protein denotes IL-4
T15759 4452-4456 Protein denotes IL-5
T15760 4457-4464 Localization denotes release
T15761 4457-4464 Localization denotes release
T15762 4434-4442 Negative_regulation denotes suppress
T15763 4434-4442 Negative_regulation denotes suppress
T15764 4785-4795 Protein denotes importin-α
T15765 4855-4860 Protein denotes MKP-1
T15766 4877-4885 Protein denotes p38 MAPK
T15767 4926-4932 Protein denotes GATA-3
T15768 4980-4986 Protein denotes GATA-3
T15769 4702-4709 Entity denotes nuclear
T15770 4740-4747 Binding denotes binding
T15771 4842-4851 Gene_expression denotes synthesis
T15772 4868-4876 Negative_regulation denotes inhibits
T15773 4907-4922 Phosphorylation denotes phosphorylation
T15774 4955-4962 Entity denotes nuclear
T15775 4963-4976 Localization denotes translocation
T15776 4832-4841 Positive_regulation denotes increased
T15777 4892-4902 Negative_regulation denotes preventing
T15778 4941-4950 Positive_regulation denotes necessary
T15779 5208-5234 Protein denotes nasal Th2 cytokine release
T15780 5373-5383 Protein denotes importin-α
T15781 5356-5367 Binding denotes interaction
T15782 5327-5337 Negative_regulation denotes Prevention
R13478 T15647 T15648 themeOf Th2 genes,transcription
R13483 T15649 T15653 themeOf GR,compete
R13488 T15650 T15653 themeOf GATA-3,compete
R13489 T15650 T15654 themeOf GATA-3,activated
R13490 T15651 T15657 themeOf GATA-3,transport
R13491 T15652 T15658 themeOf GR,transport
R13492 T15656 T15657 locationOf nuclear,transport
R13493 T15656 T15658 locationOf nuclear,transport
R13494 T15725 T15727 themeOf MKP-1,induction
R13495 T15726 T15728 themeOf MAPK,inhibitor
R13496 T15657 T15659 themeOf transport,required
R13497 T15727 T15729 themeOf induction,modulate
R13498 T15728 T15730 themeOf inhibitor,induction
R13499 T15658 T15660 themeOf transport,required
R13500 T15731 T15733 themeOf MKP-1 mRNA,induction
R13501 T15661 T15667 themeOf MKP-1,expression
R13502 T15734 T15736 themeOf MKP-1,induction
R13503 T15662 T15668 themeOf p38 MAPK,inhibitor
R13504 T15735 T15738 themeOf p38 MAPK,attenuating
R13505 T15735 T15739 themeOf p38 MAPK,phosphorylation
R13506 T15736 T15738 causeOf induction,attenuating
R13507 T15736 T15741 causeOf induction,attenuating
R13508 T15664 T15669 themeOf p38 MAPK,activation
R13509 T15739 T15741 themeOf phosphorylation,attenuating
R13510 T15665 T15670 themeOf GATA-3,phosphorylation
R13511 T15742 T15745 themeOf GATA-3,phosphorylated
R13512 T15665 T15677 causeOf GATA-3,necessary
R13513 T15666 T15671 themeOf importin-α,interaction
R13514 T15747 T15749 themeOf IL-4 mRNA,expression
R13515 T15748 T15750 themeOf IL-4,transcription
R13516 T15666 T15673 themeOf importin-α,import
R13517 T15749 T15751 themeOf expression,effect
R13518 T15667 T15674 themeOf expression,increase
R13519 T15750 T15752 themeOf transcription,suppress
R13520 T15669 T15675 themeOf activation,prevent
R13521 T15753 T15754 themeOf GATA-3,inhibition
R13522 T15756 T15757 themeOf GATA-3,inhibiting
R13523 T15670 T15676 themeOf phosphorylation,prevent
R13524 T15758 T15760 themeOf IL-4,release
R13525 T15759 T15761 themeOf IL-5,release
R13526 T15671 T15677 themeOf interaction,necessary
R13527 T15760 T15762 themeOf release,suppress
R13528 T15761 T15763 themeOf release,suppress
R13529 T15672 T15673 locationOf nuclear,import
R13530 T15764 T15770 themeOf importin-α,binding
R13531 T15765 T15771 themeOf MKP-1,synthesis
R13532 T15678 T15682 themeOf GATA-3,translocation
R13533 T15766 T15772 themeOf p38 MAPK,inhibits
R13534 T15767 T15773 themeOf GATA-3,phosphorylation
R13535 T15767 T15778 causeOf GATA-3,necessary
R13536 T15768 T15775 themeOf GATA-3,translocation
R13537 T15771 T15776 themeOf synthesis,increased
R13538 T15773 T15777 themeOf phosphorylation,preventing
R13539 T15774 T15775 locationOf nuclear,translocation
R13540 T15775 T15778 themeOf translocation,necessary
R13541 T15679 T15681 themeOf nuclear transporter protein importin-α,interacts
R13542 T15780 T15781 themeOf importin-α,interaction
R13543 T15781 T15782 themeOf interaction,Prevention
R13544 T15680 T15682 locationOf nucleus,translocation
R13545 T15683 T15688 themeOf GATA-3,knockdown
R13546 T15687 T15689 themeOf GATA-3,transcription
R13547 T15692 T15695 themeOf importin-α,binding
R13548 T15692 T15696 themeOf importin-α,binding
R13549 T15693 T15696 themeOf GR,binding
R13550 T15693 T15697 themeOf GR,activated
R13551 T15694 T15700 themeOf Th2 gene,transcription
R13554 T15695 T15698 themeOf binding,activated
R13556 T15696 T15699 themeOf binding,activated
R13557 T15700 T15701 themeOf transcription,switch
R13561 T15700 T15702 themeOf transcription,switch
R13563 T15704 T15707 themeOf p65 subunit,translocation
R13567 T15705 T15708 themeOf NF-κB,translocation
R13571 T15706 T15707 locationOf nuclear,translocation
R13574 T15706 T15708 locationOf nuclear,translocation
R13575 T15707 T15709 themeOf translocation,affected
R13582 T15708 T15710 themeOf translocation,affected
R13586 T15712 T15715 themeOf GATA-3,exclusion
R13595 T15713 T15716 themeOf GATA-3,degradation
R13599 T15714 T15715 locationOf nuclear,exclusion
R13605 T15716 T15717 themeOf degradation,induces
R13608 T15718 T15719 themeOf GR,activated
R13615 T15720 T15721 themeOf importin-α,associate
R13617 T15722 T15723 themeOf MKP-1,induction

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T13173 371-380 Localization denotes transport
T13174 389-395 Protein denotes GATA-3
T13175 400-402 Protein denotes GR
T13176 455-463 Positive_regulation denotes increase
T13177 468-478 Gene_expression denotes expression
T13178 482-487 Protein denotes MKP-1
T13179 603-610 Negative_regulation denotes prevent
T13180 615-630 Phosphorylation denotes phosphorylation
T13181 634-640 Protein denotes GATA-3
T13182 649-658 Positive_regulation denotes necessary
T13183 649-658 Positive_regulation denotes necessary
T13184 663-674 Binding denotes interaction
T13185 695-705 Positive_regulation denotes subsequent
T13186 706-713 Entity denotes nuclear
T13187 714-720 Localization denotes import
T13188 752-765 Localization denotes translocation
T13189 769-775 Protein denotes GATA-3
T13190 802-809 Entity denotes nucleus
T13191 810-818 Regulation denotes involves
T13192 869-878 Binding denotes interacts
T13193 884-898 Phosphorylation denotes phosphorylated
T13194 899-905 Protein denotes GATA-3
T13195 950-956 Protein denotes GATA-3
T13196 957-966 Gene_expression denotes knockdown true
T13197 990-1001 Negative_regulation denotes suppression
T13198 990-1001 Negative_regulation denotes suppression
T13199 1019-1029 Positive_regulation denotes stimulated
T13200 1019-1029 Positive_regulation denotes stimulated
T13201 1030-1034 Protein denotes IL-4
T13202 1035-1039 Protein denotes IL-5
T13203 1045-1054 Transcription denotes induction
T13204 1045-1054 Transcription denotes induction
T13205 1086-1090 Regulation denotes role
T13206 1086-1090 Regulation denotes role
T13207 1095-1101 Protein denotes GATA-3
T13208 1109-1122 Transcription denotes transcription
T13209 1109-1122 Transcription denotes transcription
T13210 1183-1185 Protein denotes GR
T13211 1205-1212 Entity denotes nuclear
T13212 1213-1219 Localization denotes import
T13213 1233-1239 Protein denotes GATA-3
T13214 1281-1292 Negative_regulation denotes competition true
T13215 1318-1320 Protein denotes GR
T13216 1325-1332 Phosphorylation denotes phospho
T13217 1333-1339 Protein denotes GATA-3
T13218 1344-1351 Entity denotes nuclear
T13219 1352-1358 Localization denotes import
T13220 1414-1421 Binding denotes binding
T13221 1414-1421 Binding denotes binding
T13222 1439-1448 Positive_regulation denotes activated
T13223 1449-1451 Protein denotes GR
T13224 1457-1464 Phosphorylation denotes phospho
T13225 1465-1471 Protein denotes GATA-3
T13226 1518-1524 Negative_regulation denotes reduce true
T13227 1525-1531 Protein denotes GATA-3
T13228 1532-1537 Localization denotes entry
T13229 1688-1694 Protein denotes GATA-3
T13230 1699-1706 Entity denotes nuclear
T13231 1707-1720 Localization denotes translocation
T13232 1728-1731 Protein denotes p65
T13233 1757-1765 Regulation denotes affected true
T13234 1838-1849 Negative_regulation denotes this effect
T13235 1859-1865 Protein denotes GATA-3
T13236 1866-1873 Entity denotes nuclear
T13237 1874-1883 Localization denotes exclusion
T13238 1918-1926 Positive_regulation denotes enhances true
T13239 1927-1933 Protein denotes GATA-3
T13240 1934-1941 Entity denotes nuclear
T13241 1942-1948 Localization denotes export
T13242 1961-1968 Positive_regulation denotes induces true
T13243 1969-1975 Protein denotes GATA-3
T13244 1976-1987 Protein_catabolism denotes degradation
T13245 2076-2085 Positive_regulation denotes activated
T13246 2086-2088 Protein denotes GR
T13247 2101-2110 Negative_regulation denotes attenuate
T13248 2120-2127 Phosphorylation denotes phospho
T13249 2128-2134 Protein denotes GATA-3
T13250 2146-2157 Binding denotes association
T13251 2233-2240 Phosphorylation denotes phospho
T13252 2241-2247 Protein denotes GATA-3
T13253 2252-2261 Binding denotes associate
T13254 2459-2469 Positive_regulation denotes contribute true
T13255 2477-2486 Negative_regulation denotes reduction
T13256 2490-2496 Protein denotes GATA-3
T13257 2497-2504 Entity denotes nuclear
T13258 2505-2511 Localization denotes import
T13259 2533-2537 Regulation denotes role true
T13260 2612-2617 Protein denotes MKP-1
T13261 2618-2627 Gene_expression denotes induction
T13262 2688-2697 Positive_regulation denotes induction
T13263 2701-2706 Protein denotes MKP-1
T13264 2789-2798 Gene_expression denotes induction
T13265 2802-2807 Protein denotes MKP-1
T13266 2813-2822 Positive_regulation denotes following
T13267 2918-2927 Gene_expression denotes induction
T13268 2931-2936 Protein denotes MKP-1
T13269 2941-2947 Negative_regulation denotes reduce
T13270 2948-2954 Protein denotes GATA-3
T13271 2955-2962 Entity denotes nuclear
T13272 2963-2969 Localization denotes import
T13273 2973-2984 Negative_regulation denotes attenuating
T13274 3007-3017 Regulation denotes subsequent
T13275 3018-3024 Protein denotes GATA-3
T13276 3025-3040 Phosphorylation denotes phosphorylation
T13277 3047-3057 Negative_regulation denotes preventing true
T13278 3058-3065 Entity denotes nuclear
T13279 3066-3079 Localization denotes translocation
T13280 3101-3115 Entity denotes serine residue
T13281 3122-3128 Protein denotes GATA-3
T13282 3138-3152 Phosphorylation denotes phosphorylated
T13283 3387-3397 Negative_regulation denotes impairment
T13284 3401-3407 Protein denotes GATA-3
T13285 3408-3415 Entity denotes nuclear
T13286 3416-3422 Localization denotes import
T13287 3568-3585 Negative_regulation denotes inhibitory effect true true
T13288 3599-3609 Transcription denotes expression
T13289 3613-3617 Protein denotes IL-4
T13290 3775-3783 Negative_regulation denotes suppress
T13291 3784-3788 Protein denotes IL-4
T13292 3789-3802 Transcription denotes transcription
T13293 3945-3951 Protein denotes GATA-3
T13294 3952-3962 Negative_regulation denotes inhibition
T13295 4089-4099 Negative_regulation denotes inhibiting
T13296 4100-4106 Protein denotes GATA-3
T13297 4434-4442 Negative_regulation denotes suppress
T13298 4434-4442 Negative_regulation denotes suppress
T13299 4443-4447 Protein denotes IL-4
T13300 4452-4456 Protein denotes IL-5
T13301 4457-4464 Localization denotes release
T13302 4457-4464 Localization denotes release
T13303 4674-4691 Negative_regulation denotes inhibitory effect
T13304 4674-4691 Negative_regulation denotes inhibitory effect
T13305 4695-4701 Protein denotes GATA-3
T13306 4702-4709 Entity denotes nuclear
T13307 4710-4723 Localization denotes translocation
T13308 4740-4747 Binding denotes binding
T13309 4832-4841 Positive_regulation denotes increased
T13310 4842-4851 Gene_expression denotes synthesis
T13311 4855-4860 Protein denotes MKP-1
T13312 4892-4902 Negative_regulation denotes preventing
T13313 4907-4922 Phosphorylation denotes phosphorylation
T13314 4926-4932 Protein denotes GATA-3
T13315 4941-4950 Positive_regulation denotes necessary
T13316 4955-4962 Entity denotes nuclear
T13317 4963-4976 Localization denotes translocation
T13318 4980-4986 Protein denotes GATA-3
T13319 5327-5337 Negative_regulation denotes Prevention
T13320 5341-5348 Phosphorylation denotes phospho
T13321 5349-5355 Protein denotes GATA-3
T13160 108-114 Protein denotes GATA-3
T13161 248-257 Positive_regulation denotes activated
T13162 258-260 Protein denotes GR
T13163 272-279 Negative_regulation denotes compete
T13164 285-294 Positive_regulation denotes activated
T13165 295-301 Protein denotes GATA-3
T13166 306-313 Entity denotes nuclear
T13167 314-320 Localization denotes import
T13168 321-324 Regulation denotes via
T13169 346-354 Regulation denotes required
T13170 346-354 Regulation denotes required
T13171 363-370 Entity denotes nuclear
T13172 371-380 Localization denotes transport
T13322 5356-5367 Binding denotes interaction
R11287 T13162 T13161 themeOf GR,activated
R11288 T13162 T13163 causeOf GR,compete
R11289 T13165 T13163 themeOf GATA-3,compete
R11294 T13171 T13173 locationOf nuclear,transport
R11295 T13171 T13172 locationOf nuclear,transport
R11296 T13172 T13169 themeOf transport,required
R11297 T13173 T13170 themeOf transport,required
R11298 T13174 T13173 themeOf GATA-3,transport
R11299 T13175 T13172 themeOf GR,transport
R11300 T13177 T13176 themeOf expression,increase
R11301 T13178 T13177 themeOf MKP-1,expression
R11302 T13180 T13179 themeOf phosphorylation,prevent
R11303 T13180 T13182 causeOf phosphorylation,necessary
R11304 T13180 T13183 causeOf phosphorylation,necessary
R11305 T13181 T13180 themeOf GATA-3,phosphorylation
R11306 T13181 T13184 themeOf GATA-3,interaction
R11307 T13181 T13187 themeOf GATA-3,import
R11308 T13184 T13182 themeOf interaction,necessary
R11309 T13184 T13185 causeOf interaction,subsequent
R11310 T13186 T13187 locationOf nuclear,import
R11311 T13187 T13183 themeOf import,necessary
R11312 T13187 T13185 themeOf import,subsequent
R11313 T13188 T13191 themeOf translocation,involves
R11314 T13189 T13188 themeOf GATA-3,translocation
R11315 T13190 T13188 locationOf nucleus,translocation
R11316 T13194 T13192 themeOf GATA-3,interacts
R11317 T13194 T13193 themeOf GATA-3,phosphorylated
R11318 T13195 T13196 themeOf GATA-3,knockdown
R11319 T13196 T13197 causeOf knockdown,suppression
R11320 T13196 T13198 causeOf knockdown,suppression
R11321 T13199 T13198 themeOf stimulated,suppression
R11322 T13200 T13197 themeOf stimulated,suppression
R11323 T13201 T13203 themeOf IL-4,induction
R11324 T13201 T13209 themeOf IL-4,transcription
R11325 T13202 T13204 themeOf IL-5,induction
R11326 T13202 T13208 themeOf IL-5,transcription
R11327 T13203 T13200 themeOf induction,stimulated
R11328 T13204 T13199 themeOf induction,stimulated
R11329 T13207 T13206 causeOf GATA-3,role
R11330 T13207 T13205 causeOf GATA-3,role
R11331 T13208 T13205 themeOf transcription,role
R11332 T13209 T13206 themeOf transcription,role
R11333 T13210 T13212 themeOf GR,import
R11334 T13211 T13212 locationOf nuclear,import
R11335 T13215 T13214 causeOf GR,competition
R11336 T13217 T13219 themeOf GATA-3,import
R11337 T13217 T13216 themeOf GATA-3,phospho
R11338 T13218 T13219 locationOf nuclear,import
R11339 T13219 T13214 themeOf import,competition
R11340 T13223 T13220 themeOf GR,binding
R11341 T13223 T13222 themeOf GR,activated
R11342 T13225 T13221 themeOf GATA-3,binding
R11343 T13225 T13224 themeOf GATA-3,phospho
R11344 T13227 T13228 themeOf GATA-3,entry
R11345 T13228 T13226 themeOf entry,reduce
R11346 T13230 T13231 locationOf nuclear,translocation
R11347 T13231 T13233 themeOf translocation,affected
R11348 T13232 T13231 themeOf p65,translocation
R11349 T13235 T13237 themeOf GATA-3,exclusion
R11350 T13236 T13237 locationOf nuclear,exclusion
R11351 T13237 T13234 themeOf exclusion,this effect
R11352 T13239 T13241 themeOf GATA-3,export
R11354 T13241 T13238 themeOf export,enhances
R11367 T13258 T13255 themeOf import,reduction
R11368 T13260 T13261 themeOf MKP-1,induction
R11369 T13261 T13259 themeOf induction,role
R11370 T13263 T13262 themeOf MKP-1,induction
R11371 T13264 T13266 themeOf induction,following
R11372 T13265 T13264 themeOf MKP-1,induction
R11373 T13267 T13273 causeOf induction,attenuating
R11374 T13268 T13267 themeOf MKP-1,induction
R11376 T13270 T13272 themeOf GATA-3,import
R11377 T13271 T13272 locationOf nuclear,import
R11378 T13272 T13269 themeOf import,reduce
R11380 T13273 T13269 causeOf attenuating,reduce
R11381 T13274 T13273 themeOf subsequent,attenuating
R11382 T13275 T13276 themeOf GATA-3,phosphorylation
R11383 T13276 T13274 themeOf phosphorylation,subsequent
R11401 T13305 T13307 themeOf GATA-3,translocation
R11402 T13305 T13308 themeOf GATA-3,binding
R11403 T13306 T13307 locationOf nuclear,translocation
R11404 T13307 T13304 themeOf translocation,inhibitory effect
R11405 T13307 T13303 themeOf translocation,inhibitory effect
R11406 T13308 T13304 causeOf binding,inhibitory effect
R11407 T13309 T13303 causeOf increased,inhibitory effect
R11408 T13309 T13312 causeOf increased,preventing
R11409 T13310 T13309 themeOf synthesis,increased
R11410 T13311 T13310 themeOf MKP-1,synthesis
R11411 T13313 T13312 themeOf phosphorylation,preventing
R11412 T13314 T13313 themeOf GATA-3,phosphorylation
R11413 T13316 T13317 locationOf nuclear,translocation
R11414 T13317 T13315 themeOf translocation,necessary
R11415 T13318 T13317 themeOf GATA-3,translocation
R11416 T13321 T13322 themeOf GATA-3,interaction
R11417 T13321 T13320 themeOf GATA-3,phospho
R11418 T13322 T13319 themeOf interaction,Prevention
R11398 T13300 T13302 themeOf IL-5,release
R11292 T13166 T13167 locationOf nuclear,import
R11293 T13167 T13168 themeOf import,via
R11375 T13270 T13279 themeOf GATA-3,translocation
R11379 T13273 T13277 causeOf attenuating,preventing
R11384 T13278 T13279 locationOf nuclear,translocation
R11385 T13279 T13277 themeOf translocation,preventing
R11386 T13280 T13282 themeOf serine residue,phosphorylated
R11387 T13280 T13281 partOf serine residue,GATA-3
R11388 T13284 T13286 themeOf GATA-3,import
R11389 T13285 T13286 locationOf nuclear,import
R11390 T13286 T13283 themeOf import,impairment
R11391 T13288 T13287 themeOf expression,inhibitory effect
R11392 T13289 T13288 themeOf IL-4,expression
R11393 T13291 T13292 themeOf IL-4,transcription
R11394 T13292 T13290 themeOf transcription,suppress
R11395 T13293 T13294 themeOf GATA-3,inhibition
R11396 T13296 T13295 themeOf GATA-3,inhibiting
R11397 T13299 T13301 themeOf IL-4,release
R11399 T13301 T13298 themeOf release,suppress
R11400 T13302 T13297 themeOf release,suppress
R11290 T13165 T13164 themeOf GATA-3,activated
R11291 T13165 T13167 themeOf GATA-3,import
R11353 T13240 T13241 locationOf nuclear,export
R11355 T13243 T13244 themeOf GATA-3,degradation
R11356 T13244 T13242 themeOf degradation,induces
R11357 T13246 T13245 themeOf GR,activated
R11358 T13246 T13247 causeOf GR,attenuate
R11359 T13249 T13250 themeOf GATA-3,association
R11360 T13249 T13248 themeOf GATA-3,phospho
R11361 T13250 T13247 themeOf association,attenuate
R11362 T13252 T13251 themeOf GATA-3,phospho
R11363 T13252 T13253 themeOf GATA-3,associate
R11364 T13255 T13254 themeOf reduction,contribute
R11365 T13256 T13258 themeOf GATA-3,import
R11366 T13257 T13258 locationOf nuclear,import

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T14226 108-114 P23771 denotes GATA-3
T14227 258-260 P04150 denotes GR
T14228 295-301 P23771 denotes GATA-3
T14229 389-395 P23771 denotes GATA-3
T14230 400-402 P04150 denotes GR
T14231 482-487 P28562 denotes MKP-1
T14232 511-514 Q16539 denotes p38
T14233 511-514 Q15759 denotes p38
T14234 511-514 P53778 denotes p38
T14235 511-514 O15264 denotes p38
T14236 591-594 P53778 denotes p38
T14237 591-594 Q15759 denotes p38
T14238 591-594 Q16539 denotes p38
T14239 591-594 O15264 denotes p38
T14240 634-640 P23771 denotes GATA-3
T14241 769-775 P23771 denotes GATA-3
T14242 899-905 P23771 denotes GATA-3
T14243 950-956 P23771 denotes GATA-3
T14244 1010-1013 P04234 denotes CD3
T14245 1010-1013 P09693 denotes CD3
T14246 1010-1013 P20963 denotes CD3
T14247 1010-1013 P07766 denotes CD3
T14248 1014-1018 P10747 denotes CD28
T14249 1030-1034 P05112 denotes IL-4
T14250 1035-1039 P05113 denotes IL-5
T14251 1095-1101 P23771 denotes GATA-3
T14252 1183-1185 P04150 denotes GR
T14253 1233-1239 P23771 denotes GATA-3
T14254 1318-1320 P04150 denotes GR
T14255 1333-1339 P23771 denotes GATA-3
T14256 1449-1451 P04150 denotes GR
T14257 1465-1471 P23771 denotes GATA-3
T14258 1525-1531 P23771 denotes GATA-3
T14259 1688-1694 P23771 denotes GATA-3
T14260 1728-1731 Q04206 denotes p65
T14261 1728-1731 P21579 denotes p65
T14262 1859-1865 P23771 denotes GATA-3
T14263 1927-1933 P23771 denotes GATA-3
T14264 1969-1975 P23771 denotes GATA-3
T14265 2086-2088 P04150 denotes GR
T14266 2128-2134 P23771 denotes GATA-3
T14267 2241-2247 P23771 denotes GATA-3
T14268 2490-2496 P23771 denotes GATA-3
T14269 2612-2617 P28562 denotes MKP-1
T14270 2658-2661 P53778 denotes p38
T14271 2658-2661 O15264 denotes p38
T14272 2658-2661 Q16539 denotes p38
T14273 2658-2661 Q15759 denotes p38
T14274 2701-2706 P28562 denotes MKP-1
T14275 2802-2807 P28562 denotes MKP-1
T14276 2849-2859 Q04864 denotes relatively
T14277 2931-2936 P28562 denotes MKP-1
T14278 2948-2954 P23771 denotes GATA-3
T14279 2985-2988 Q16539 denotes p38
T14280 2985-2988 P53778 denotes p38
T14281 2985-2988 Q15759 denotes p38
T14282 2985-2988 O15264 denotes p38
T14283 3018-3024 P23771 denotes GATA-3
T14284 3122-3128 P23771 denotes GATA-3
T14285 3156-3159 P53778 denotes p38
T14286 3156-3159 O15264 denotes p38
T14287 3156-3159 Q15759 denotes p38
T14288 3156-3159 Q16539 denotes p38
T14294 3613-3617 P05112 denotes IL-4
T14295 3784-3788 P05112 denotes IL-4
T14296 3945-3951 P23771 denotes GATA-3
T14297 4100-4106 P23771 denotes GATA-3
T14298 4443-4447 P05112 denotes IL-4
T14299 4452-4456 P05113 denotes IL-5
T14300 4695-4701 P23771 denotes GATA-3
T14301 4855-4860 P28562 denotes MKP-1
T14302 4877-4880 Q16539 denotes p38
T14303 4877-4880 Q15759 denotes p38
T14304 4877-4880 P53778 denotes p38
T14305 4877-4880 O15264 denotes p38
T14306 4926-4932 P23771 denotes GATA-3
T14307 4980-4986 P23771 denotes GATA-3
T14308 5349-5355 P23771 denotes GATA-3
T14289 3312-3315 Q16539 denotes p38
T14290 3312-3315 Q15759 denotes p38
T14291 3312-3315 O15264 denotes p38
T14292 3312-3315 P53778 denotes p38
T14293 3401-3407 P23771 denotes GATA-3

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T13008 100-107 Negative_regulation denotes inhibit
T13009 108-114 Protein denotes GATA-3
T13010 248-257 Positive_regulation denotes activated
T13011 258-260 Protein denotes GR
T13012 285-294 Positive_regulation denotes activated
T13013 295-301 Protein denotes GATA-3
T13014 306-313 Entity denotes nuclear
T13015 314-320 Localization denotes import
T13016 321-324 Positive_regulation denotes via
T13017 346-354 Positive_regulation denotes required
T13018 363-370 Entity denotes nuclear
T13019 371-380 Localization denotes transport
T13020 389-395 Protein denotes GATA-3
T13021 400-402 Protein denotes GR
T13022 455-463 Positive_regulation denotes increase
T13023 468-478 Gene_expression denotes expression
T13024 482-487 Protein denotes MKP-1
T13025 603-610 Negative_regulation denotes prevent
T13026 615-630 Phosphorylation denotes phosphorylation
T13027 634-640 Protein denotes GATA-3
T13028 649-658 Positive_regulation denotes necessary
T13029 663-674 Binding denotes interaction
T13030 706-713 Entity denotes nuclear true
T13031 714-720 Localization denotes import
T13032 752-765 Localization denotes translocation
T13033 769-775 Protein denotes GATA-3
T13034 802-809 Entity denotes nucleus
T13035 810-818 Positive_regulation denotes involves
T13036 869-878 Binding denotes interacts
T13037 884-898 Phosphorylation denotes phosphorylated
T13038 899-905 Protein denotes GATA-3
T13039 950-956 Protein denotes GATA-3
T13040 957-966 Negative_regulation denotes knockdown
T13041 990-1001 Negative_regulation denotes suppression
T13042 1019-1029 Positive_regulation denotes stimulated true
T13043 1030-1034 Protein denotes IL-4
T13044 1035-1039 Protein denotes IL-5
T13045 1040-1044 Transcription denotes mRNA
T13046 1045-1054 Positive_regulation denotes induction
T13047 1086-1090 Regulation denotes role
T13048 1095-1101 Protein denotes GATA-3
T13049 1183-1185 Protein denotes GR true
T13050 1205-1212 Entity denotes nuclear
T13051 1213-1219 Localization denotes import
T13052 1233-1239 Protein denotes GATA-3 true
T13053 1308-1317 Positive_regulation denotes activated
T13054 1318-1320 Protein denotes GR
T13055 1325-1332 Phosphorylation denotes phospho true
T13056 1333-1339 Protein denotes GATA-3
T13057 1344-1351 Entity denotes nuclear true
T13058 1352-1358 Localization denotes import
T13059 1414-1421 Binding denotes binding
T13060 1439-1448 Positive_regulation denotes activated
T13061 1449-1451 Protein denotes GR
T13062 1457-1464 Phosphorylation denotes phospho
T13063 1465-1471 Protein denotes GATA-3
T13064 1518-1524 Negative_regulation denotes reduce
T13065 1525-1531 Protein denotes GATA-3 true
T13066 1532-1537 Binding denotes entry
T13067 1688-1694 Protein denotes GATA-3
T13068 1699-1706 Entity denotes nuclear true
T13069 1707-1720 Localization denotes translocation
T13070 1728-1731 Protein denotes p65
T13071 1757-1765 Regulation denotes affected
T13072 1843-1849 Regulation denotes effect
T13073 1859-1865 Protein denotes GATA-3
T13074 1866-1873 Entity denotes nuclear
T13075 1874-1883 Localization denotes exclusion
T13076 1918-1926 Positive_regulation denotes enhances
T13077 1927-1933 Protein denotes GATA-3
T13078 1934-1941 Entity denotes nuclear
T13079 1942-1948 Localization denotes export true
T13080 1961-1968 Positive_regulation denotes induces
T13081 1969-1975 Protein denotes GATA-3
T13082 1976-1987 Protein_catabolism denotes degradation
T13083 2076-2085 Positive_regulation denotes activated
T13084 2086-2088 Protein denotes GR true true
T13085 2101-2110 Negative_regulation denotes attenuate
T13086 2120-2127 Phosphorylation denotes phospho
T13087 2128-2134 Protein denotes GATA-3
T13088 2146-2157 Binding denotes association
T13089 2233-2240 Phosphorylation denotes phospho
T13090 2241-2247 Protein denotes GATA-3
T13091 2252-2261 Binding denotes associate
T13092 2459-2469 Positive_regulation denotes contribute
T13093 2477-2486 Negative_regulation denotes reduction
T13094 2490-2496 Protein denotes GATA-3
T13095 2497-2504 Entity denotes nuclear
T13096 2505-2511 Localization denotes import
T13097 2612-2617 Protein denotes MKP-1
T13098 2618-2627 Positive_regulation denotes induction
T13099 2688-2697 Positive_regulation denotes induction
T13100 2701-2706 Protein denotes MKP-1
T13101 2789-2798 Positive_regulation denotes induction
T13102 2802-2807 Protein denotes MKP-1
T13103 2813-2822 Positive_regulation denotes following
T13104 2918-2927 Positive_regulation denotes induction
T13105 2931-2936 Protein denotes MKP-1
T13106 2941-2947 Negative_regulation denotes reduce
T13107 2948-2954 Protein denotes GATA-3
T13108 2955-2962 Entity denotes nuclear
T13109 2963-2969 Localization denotes import
T13110 3007-3017 Positive_regulation denotes subsequent
T13111 3018-3024 Protein denotes GATA-3
T13112 3025-3040 Phosphorylation denotes phosphorylation
T13113 3047-3057 Negative_regulation denotes preventing
T13114 3058-3065 Entity denotes nuclear
T13115 3066-3079 Localization denotes translocation
T13116 3101-3115 Entity denotes serine residue
T13117 3122-3128 Protein denotes GATA-3
T13118 3138-3152 Phosphorylation denotes phosphorylated
T13119 3401-3407 Protein denotes GATA-3
T13120 3408-3415 Entity denotes nuclear
T13121 3416-3422 Localization denotes import
T13122 3568-3578 Negative_regulation denotes inhibitory
T13123 3579-3585 Regulation denotes effect
T13124 3599-3609 Gene_expression denotes expression
T13125 3613-3617 Protein denotes IL-4
T13126 3775-3783 Negative_regulation denotes suppress
T13127 3784-3788 Protein denotes IL-4
T13128 3789-3802 Transcription denotes transcription
T13129 3932-3940 Positive_regulation denotes required
T13130 3945-3951 Protein denotes GATA-3
T13131 3952-3962 Negative_regulation denotes inhibition
T13132 4089-4099 Negative_regulation denotes inhibiting
T13133 4100-4106 Protein denotes GATA-3
T13134 4434-4442 Negative_regulation denotes suppress
T13135 4443-4447 Protein denotes IL-4
T13136 4452-4456 Protein denotes IL-5
T13137 4457-4464 Localization denotes release
T13138 4685-4691 Regulation denotes effect
T13139 4695-4701 Protein denotes GATA-3
T13140 4702-4709 Entity denotes nuclear
T13141 4710-4723 Localization denotes translocation
T13142 4740-4747 Binding denotes binding
T13143 4762-4769 Entity denotes nuclear
T13144 4770-4776 Localization denotes import
T13145 4832-4841 Positive_regulation denotes increased
T13146 4842-4851 Gene_expression denotes synthesis
T13147 4855-4860 Protein denotes MKP-1
T13148 4892-4902 Negative_regulation denotes preventing
T13149 4907-4922 Phosphorylation denotes phosphorylation
T13150 4926-4932 Protein denotes GATA-3
T13151 4941-4950 Positive_regulation denotes necessary
T13152 4955-4962 Entity denotes nuclear
T13153 4963-4976 Localization denotes translocation
T13154 4980-4986 Protein denotes GATA-3
T13155 5327-5337 Negative_regulation denotes Prevention
T13156 5341-5348 Phosphorylation denotes phospho
T13157 5349-5355 Protein denotes GATA-3
T13158 5356-5367 Binding denotes interaction
R11178 T13009 T13008 themeOf GATA-3,inhibit
R11179 T13011 T13010 themeOf GR,activated
R11180 T13013 T13015 themeOf GATA-3,import
R11181 T13014 T13015 locationOf nuclear,import
R11182 T13015 T13016 themeOf import,via
R11183 T13018 T13019 locationOf nuclear,transport
R11184 T13019 T13017 themeOf transport,required
R11185 T13020 T13019 themeOf GATA-3,transport
R11186 T13021 T13019 themeOf GR,transport
R11187 T13023 T13022 themeOf expression,increase
R11188 T13024 T13023 themeOf MKP-1,expression
R11189 T13026 T13028 causeOf phosphorylation,necessary
R11190 T13026 T13025 themeOf phosphorylation,prevent
R11191 T13027 T13029 themeOf GATA-3,interaction
R11192 T13027 T13031 themeOf GATA-3,import
R11193 T13027 T13026 themeOf GATA-3,phosphorylation
R11194 T13029 T13028 themeOf interaction,necessary
R11195 T13030 T13031 locationOf nuclear,import
R11196 T13031 T13028 themeOf import,necessary
R11197 T13032 T13035 themeOf translocation,involves
R11198 T13033 T13032 themeOf GATA-3,translocation
R11199 T13034 T13032 locationOf nucleus,translocation
R11200 T13038 T13037 themeOf GATA-3,phosphorylated
R11201 T13038 T13036 themeOf GATA-3,interacts
R11202 T13039 T13040 themeOf GATA-3,knockdown
R11203 T13040 T13041 causeOf knockdown,suppression
R11204 T13043 T13046 themeOf IL-4,induction
R11205 T13046 T13042 themeOf induction,stimulated
R11206 T13048 T13047 causeOf GATA-3,role
R11207 T13049 T13051 themeOf GR,import
R11208 T13050 T13051 locationOf nuclear,import
R11209 T13054 T13058 themeOf GR,import
R11210 T13054 T13053 themeOf GR,activated
R11211 T13056 T13058 themeOf GATA-3,import
R11212 T13056 T13055 themeOf GATA-3,phospho
R11213 T13057 T13058 locationOf nuclear,import
R11214 T13061 T13060 themeOf GR,activated
R11215 T13063 T13062 themeOf GATA-3,phospho
R11216 T13065 T13066 themeOf GATA-3,entry
R11217 T13065 T13064 themeOf GATA-3,reduce
R11218 T13066 T13064 themeOf entry,reduce
R11219 T13068 T13069 locationOf nuclear,translocation
R11220 T13069 T13071 themeOf translocation,affected
R11221 T13070 T13069 themeOf p65,translocation
R11222 T13073 T13075 themeOf GATA-3,exclusion
R11223 T13074 T13075 locationOf nuclear,exclusion
R11224 T13075 T13072 themeOf exclusion,effect
R11225 T13077 T13079 themeOf GATA-3,export
R11226 T13078 T13079 locationOf nuclear,export
R11227 T13079 T13076 themeOf export,enhances
R11228 T13081 T13082 themeOf GATA-3,degradation
R11229 T13082 T13080 themeOf degradation,induces
R11230 T13084 T13085 causeOf GR,attenuate
R11231 T13084 T13083 themeOf GR,activated
R11232 T13086 T13085 themeOf phospho,attenuate
R11233 T13087 T13088 themeOf GATA-3,association
R11234 T13088 T13085 themeOf association,attenuate
R11235 T13090 T13089 themeOf GATA-3,phospho
R11236 T13090 T13091 themeOf GATA-3,associate
R11237 T13093 T13092 themeOf reduction,contribute
R11238 T13094 T13096 themeOf GATA-3,import
R11239 T13095 T13096 locationOf nuclear,import
R11240 T13096 T13093 themeOf import,reduction
R11241 T13097 T13098 themeOf MKP-1,induction
R11242 T13098 T13093 themeOf induction,reduction
R11243 T13100 T13099 themeOf MKP-1,induction
R11244 T13101 T13103 themeOf induction,following
R11245 T13102 T13101 themeOf MKP-1,induction
R11246 T13105 T13104 themeOf MKP-1,induction
R11247 T13107 T13115 themeOf GATA-3,translocation
R11248 T13107 T13109 themeOf GATA-3,import
R11249 T13108 T13109 locationOf nuclear,import
R11250 T13109 T13106 themeOf import,reduce
R11251 T13111 T13115 themeOf GATA-3,translocation
R11252 T13111 T13112 themeOf GATA-3,phosphorylation
R11253 T13112 T13113 causeOf phosphorylation,preventing
R11254 T13112 T13110 themeOf phosphorylation,subsequent
R11255 T13114 T13115 locationOf nuclear,translocation
R11256 T13115 T13113 themeOf translocation,preventing
R11257 T13116 T13118 themeOf serine residue,phosphorylated
R11258 T13116 T13117 partOf serine residue,GATA-3
R11259 T13119 T13121 themeOf GATA-3,import
R11260 T13120 T13121 locationOf nuclear,import
R11261 T13125 T13124 themeOf IL-4,expression
R11262 T13127 T13128 themeOf IL-4,transcription
R11263 T13128 T13126 themeOf transcription,suppress
R11264 T13130 T13131 themeOf GATA-3,inhibition
R11265 T13131 T13129 themeOf inhibition,required
R11266 T13133 T13132 themeOf GATA-3,inhibiting
R11267 T13135 T13137 themeOf IL-4,release
R11268 T13136 T13137 themeOf IL-5,release
R11269 T13137 T13134 themeOf release,suppress
R11270 T13139 T13144 themeOf GATA-3,import
R11271 T13139 T13141 themeOf GATA-3,translocation
R11272 T13140 T13141 locationOf nuclear,translocation
R11273 T13141 T13138 themeOf translocation,effect
R11274 T13143 T13144 locationOf nuclear,import
R11275 T13146 T13145 themeOf synthesis,increased
R11276 T13147 T13146 themeOf MKP-1,synthesis
R11277 T13149 T13151 causeOf phosphorylation,necessary
R11278 T13149 T13148 themeOf phosphorylation,preventing
R11279 T13150 T13149 themeOf GATA-3,phosphorylation
R11280 T13152 T13153 locationOf nuclear,translocation
R11281 T13153 T13151 themeOf translocation,necessary
R11282 T13154 T13153 themeOf GATA-3,translocation
R11283 T13156 T13155 themeOf phospho,Prevention
R11284 T13157 T13156 themeOf GATA-3,phospho
R11285 T13157 T13158 themeOf GATA-3,interaction
R11286 T13158 T13155 themeOf interaction,Prevention