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Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α.\n(A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p\u003c0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p\u003c0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p\u003c0.05 compared to GATA-3 isolated from unstimulated cells. # p\u003c0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p\u003c0.05, **p\u003c0.01 between groups. All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test. "}

{"project":"GO-BP","denotations":[{"id":"T18536","span":{"begin":246,"end":264},"obj":"http://purl.obolibrary.org/obo/GO_0005049"}],"text":"10.1371/journal.pmed.1000076.g004 Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α.\n(A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p\u003c0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p\u003c0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p\u003c0.05 compared to GATA-3 isolated from unstimulated cells. # p\u003c0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p\u003c0.05, **p\u003c0.01 between groups. All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test. "}

{"project":"GO-MF","denotations":[{"id":"T18537","span":{"begin":157,"end":164},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T18538","span":{"begin":257,"end":264},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T18539","span":{"begin":654,"end":661},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T18540","span":{"begin":778,"end":785},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T18541","span":{"begin":246,"end":264},"obj":"http://purl.obolibrary.org/obo/GO_0005049"}],"text":"10.1371/journal.pmed.1000076.g004 Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α.\n(A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p\u003c0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p\u003c0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p\u003c0.05 compared to GATA-3 isolated from unstimulated cells. # p\u003c0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p\u003c0.05, **p\u003c0.01 between groups. All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test. "}

{"project":"GO-CC","denotations":[{"id":"T18542","span":{"begin":228,"end":233},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18543","span":{"begin":410,"end":415},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18544","span":{"begin":593,"end":598},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18545","span":{"begin":723,"end":728},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"10.1371/journal.pmed.1000076.g004 Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α.\n(A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p\u003c0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p\u003c0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p\u003c0.05 compared to GATA-3 isolated from unstimulated cells. # p\u003c0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p\u003c0.05, **p\u003c0.01 between groups. All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test. "}

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