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2_test

Id Subject Object Predicate Lexical cue
19436703-12876556-86274493 189-191 12876556 denotes 32
19436703-17277157-86274494 449-451 17277157 denotes 12
19436703-11140432-86274495 791-793 11140432 denotes 37
19436703-17314103-86274496 2758-2760 17314103 denotes 20
19436703-15496417-86274497 5301-5303 15496417 denotes 28
19436703-15591061-86274498 12827-12829 15591061 denotes 27
T38523 189-191 12876556 denotes 32
T73484 449-451 17277157 denotes 12
T58090 791-793 11140432 denotes 37
T64889 2758-2760 17314103 denotes 20
T59134 5301-5303 15496417 denotes 28
T7645 12827-12829 15591061 denotes 27

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T8245 9-12 DT denotes The
T8246 13-19 NN denotes Effect
T8247 20-22 IN denotes of
T8248 23-38 NN denotes Corticosteroids
T8249 39-41 IN denotes on
T8250 42-48 NN denotes GATA-3
T8251 49-56 JJ denotes Nuclear
T8252 57-70 NN denotes Translocation
T8253 71-74 CC denotes and
T8254 75-79 NN denotes IL-4
T8255 80-84 NN denotes mRNA
T8256 85-100 NN denotes Corticosteroids
T8257 101-104 VB denotes are
T8258 105-114 JJ denotes effective
T8259 115-117 IN denotes in
T8260 118-128 VB denotes inhibiting
T8261 129-145 JJ denotes GATA-3-regulated
T8262 146-150 NN denotes IL-4
T8263 151-155 NN denotes gene
T8264 156-166 NN denotes expression
T8265 167-169 FW denotes in
T8266 170-175 FW denotes vitro
T8267 176-179 CC denotes and
T8268 180-182 FW denotes in
T8269 183-187 FW denotes vivo
T8270 188-189 -LRB- denotes [
T8271 189-191 CD denotes 32
T8272 191-192 -RRB- denotes ]
T8273 194-196 PRP denotes We
T8274 197-206 RB denotes therefore
T8275 207-219 VB denotes investigated
T8276 220-227 IN denotes whether
T8277 228-243 NN denotes corticosteroids
T8278 244-250 VB denotes affect
T8279 251-275 JJ denotes anti-CD3/CD28–stimulated
T8280 276-283 JJ denotes nuclear
T8281 284-290 NN denotes import
T8282 291-293 IN denotes of
T8283 294-300 NN denotes GATA-3
T8284 302-313 NN denotes Stimulation
T8285 314-316 IN denotes of
T8286 317-322 NN denotes cells
T8287 323-327 IN denotes with
T8288 328-341 NN denotes anti-CD3/CD28
T8289 342-350 VB denotes resulted
T8290 351-353 IN denotes in
T8291 354-355 DT denotes a
T8292 356-361 JJ denotes rapid
T8293 362-381 JJ denotes cytoplasmic/nuclear
T8294 382-388 NN denotes GATA-3
T8295 389-402 NN denotes translocation
T8296 403-404 -LRB- denotes (
T8297 404-410 NN denotes Figure
T8298 411-413 NN denotes 1A
T8299 413-414 -RRB- denotes )
T8300 414-415 -COMMA- denotes ,
T8301 416-426 VB denotes confirming
T8302 427-430 PRP-DOLLAR- denotes our
T8303 431-439 JJ denotes previous
T8304 440-447 NN denotes results
T8305 448-449 -LRB- denotes [
T8306 449-451 CD denotes 12
T8307 451-452 -RRB- denotes ]
T8308 454-456 PRP denotes We
T8309 457-461 RB denotes also
T8310 462-471 VB denotes confirmed
T8311 472-473 DT denotes a
T8312 474-479 JJ denotes clear
T8313 480-490 NN denotes separation
T8314 491-493 IN denotes of
T8315 494-501 JJ denotes nuclear
T8316 502-505 CC denotes and
T8317 506-515 JJ denotes cytosolic
T8318 516-525 NN denotes fractions
T8319 526-528 IN denotes as
T8320 529-538 VB denotes indicated
T8321 539-541 IN denotes by
T8322 542-549 NN denotes histone
T8323 550-552 NN denotes H1
T8324 553-556 CC denotes and
T8325 557-562 NN denotes MEK-1
T8326 563-570 NN denotes markers
T8327 571-572 -LRB- denotes (
T8328 572-578 NN denotes Figure
T8329 579-581 NN denotes 1B
T8330 581-582 -RRB- denotes )
T8331 584-587 DT denotes The
T8332 588-594 JJ denotes potent
T8333 595-602 JJ denotes topical
T8334 603-617 NN denotes corticosteroid
T8335 618-620 NN denotes FP
T8336 621-627 VB denotes caused
T8337 628-637 JJ denotes sustained
T8338 638-642 NN denotes loss
T8339 643-645 IN denotes of
T8340 646-653 JJ denotes nuclear
T8341 654-660 NN denotes GATA-3
T8342 661-671 NN denotes expression
T8343 672-675 CC denotes and
T8344 676-687 JJ denotes cytoplasmic
T8345 688-697 NN denotes retention
T8346 698-700 IN denotes of
T8347 701-707 NN denotes GATA-3
T8348 708-710 IN denotes at
T8349 711-725 NN denotes concentrations
T8350 726-733 VB denotes ranging
T8351 734-738 IN denotes from
T8352 739-744 CD denotes 10−12
T8353 745-747 TO denotes to
T8354 748-752 CD denotes 10−8
T8355 753-754 NN denotes M
T8356 754-755 -COMMA- denotes ,
T8357 756-761 WDT denotes which
T8358 762-767 VB denotes cover
T8359 768-771 DT denotes the
T8360 772-783 JJ denotes therapeutic
T8361 784-789 NN denotes range
T8362 790-791 -LRB- denotes [
T8363 791-793 CD denotes 37
T8364 793-794 -RRB- denotes ]
T8365 796-800 DT denotes This
T8366 801-807 NN denotes effect
T8367 808-811 VB denotes was
T8368 812-826 NN denotes concentration-
T8369 827-830 CC denotes and
T8370 831-845 JJ denotes time-dependent
T8371 845-846 -COMMA- denotes ,
T8372 847-851 IN denotes with
T8373 852-853 DT denotes a
T8374 854-858 JJ denotes peak
T8375 859-865 NN denotes effect
T8376 866-868 IN denotes of
T8377 869-878 RB denotes 11.6-fold
T8378 879-881 IN denotes at
T8379 882-884 CD denotes 30
T8380 885-888 NN denotes min
T8381 889-891 IN denotes at
T8382 892-893 DT denotes a
T8383 894-907 NN denotes concentration
T8384 908-910 IN denotes of
T8385 911-915 CD denotes 10−8
T8386 916-917 NN denotes M
T8387 918-919 -LRB- denotes (
T8388 919-925 NN denotes Figure
T8389 926-928 NN denotes 1C
T8390 928-929 -RRB- denotes )
T8391 930-933 CC denotes and
T8392 934-937 VB denotes was
T8393 938-948 VB denotes associated
T8394 949-953 IN denotes with
T8395 954-960 JJ denotes marked
T8396 961-971 NN denotes reductions
T8397 972-974 IN denotes in
T8398 975-999 JJ denotes anti-CD3/CD28–stimulated
T8399 1000-1004 NN denotes IL-4
T8400 1005-1008 CC denotes and
T8401 1009-1013 NN denotes IL-5
T8402 1014-1018 NN denotes mRNA
T8403 1019-1029 NN denotes expression
T8404 1030-1031 -LRB- denotes (
T8405 1031-1037 NN denotes Figure
T8406 1038-1040 NN denotes 1D
T8407 1040-1041 -RRB- denotes )
T8408 1042-1045 CC denotes and
T8409 1046-1047 DT denotes a
T8410 1048-1052 NN denotes loss
T8411 1053-1055 IN denotes of
T8412 1056-1062 NN denotes GATA-3
T8413 1063-1070 NN denotes binding
T8414 1071-1073 TO denotes to
T8415 1074-1077 DT denotes the
T8416 1078-1084 JJ denotes native
T8417 1085-1089 NN denotes IL-5
T8418 1090-1098 NN denotes promoter
T8419 1099-1100 -LRB- denotes (
T8420 1100-1106 NN denotes Figure
T8421 1107-1109 NN denotes 1E
T8422 1109-1110 -RRB- denotes )
T8946 2661-2677 JJ denotes Ligand-Activated
T8947 2678-2680 NN denotes GR
T8948 2681-2689 VB denotes Competes
T8949 2690-2694 IN denotes with
T8950 2695-2701 NN denotes GATA-3
T8951 2702-2705 IN denotes for
T8952 2706-2716 NN denotes Importin-α
T8953 2717-2719 PRP denotes We
T8954 2720-2729 VB denotes confirmed
T8955 2730-2733 CC denotes and
T8956 2734-2742 VB denotes extended
T8957 2743-2751 JJ denotes previous
T8958 2752-2756 NN denotes data
T8959 2757-2758 -LRB- denotes [
T8960 2758-2760 CD denotes 20
T8961 2760-2761 -RRB- denotes ]
T8962 2762-2764 TO denotes to
T8963 2765-2769 VB denotes show
T8964 2770-2774 IN denotes that
T8965 2775-2791 JJ denotes ligand-activated
T8966 2792-2794 NN denotes GR
T8967 2795-2797 RB denotes as
T8968 2798-2802 RB denotes well
T8969 2803-2805 IN denotes as
T8970 2806-2812 NN denotes GATA-3
T8971 2813-2817 VB denotes uses
T8972 2818-2828 JJ denotes importin-α
T8973 2829-2832 IN denotes for
T8974 2833-2836 PRP-DOLLAR- denotes its
T8975 2837-2844 JJ denotes nuclear
T8976 2845-2851 NN denotes import
T8977 2852-2853 -LRB- denotes (
T8978 2853-2859 NN denotes Figure
T8979 2860-2862 NN denotes 2A
T8980 2863-2866 CC denotes and
T8981 2867-2869 NN denotes 2B
T8982 2869-2870 -RRB- denotes )
T8983 2872-2876 DT denotes This
T8984 2877-2888 NN denotes interaction
T8985 2889-2896 IN denotes between
T8986 2897-2899 NN denotes GR
T8987 2900-2903 CC denotes and
T8988 2904-2914 NN denotes importin-α
T8989 2915-2918 VB denotes was
T8990 2919-2930 JJ denotes significant
T8991 2931-2933 IN denotes at
T8992 2934-2948 NN denotes concentrations
T8993 2949-2951 RB denotes as
T8994 2952-2955 JJ denotes low
T8995 2956-2958 IN denotes as
T8996 2959-2964 CD denotes 10−12
T8997 2965-2966 NN denotes M
T8998 2967-2970 CC denotes and
T8999 2971-2974 VB denotes was
T9000 2975-2982 JJ denotes maximal
T9001 2983-2987 IN denotes with
T9002 2988-2992 CD denotes 10−8
T9003 2993-2994 NN denotes M
T9004 2995-2997 NN denotes FP
T9005 2999-3009 JJ denotes Subsequent
T9006 3010-3012 NN denotes GR
T9007 3013-3020 JJ denotes nuclear
T9008 3021-3034 NN denotes translocation
T9009 3035-3038 VB denotes was
T9010 3039-3044 JJ denotes rapid
T9011 3045-3048 CC denotes and
T9012 3049-3058 JJ denotes sustained
T9013 3059-3061 IN denotes at
T9014 3062-3073 JJ denotes significant
T9015 3074-3080 NN denotes levels
T9016 3081-3084 IN denotes for
T9017 3085-3087 IN denotes at
T9018 3088-3093 JJ denotes least
T9019 3094-3096 CD denotes 14
T9020 3097-3098 NN denotes h
T9021 3099-3100 -LRB- denotes (
T9022 3100-3106 NN denotes Figure
T9023 3107-3109 NN denotes 2B
T9024 3109-3110 -RRB- denotes )
T9025 3112-3117 VB denotes Using
T9026 3118-3128 JJ denotes IP-Western
T9027 3129-3137 NN denotes blotting
T9028 3138-3140 PRP denotes we
T9029 3141-3147 VB denotes showed
T9030 3148-3152 IN denotes that
T9031 3153-3155 NN denotes FP
T9032 3156-3158 IN denotes at
T9033 3159-3169 CD denotes 10−12–10−8
T9034 3170-3171 NN denotes M
T9035 3172-3181 VB denotes decreased
T9036 3182-3185 DT denotes the
T9037 3186-3197 NN denotes association
T9038 3198-3205 IN denotes between
T9039 3206-3212 NN denotes GATA-3
T9040 3213-3216 CC denotes and
T9041 3217-3227 NN denotes importin-α
T9042 3228-3235 VB denotes induced
T9043 3236-3238 IN denotes by
T9044 3239-3252 JJ denotes anti-CD3/CD28
T9045 3253-3264 NN denotes stimulation
T9046 3265-3267 IN denotes in
T9047 3268-3269 DT denotes a
T9048 3270-3293 JJ denotes concentration-dependent
T9049 3294-3300 NN denotes manner
T9050 3301-3302 -LRB- denotes (
T9051 3302-3308 NN denotes Figure
T9052 3309-3311 NN denotes 2C
T9053 3311-3312 -RRB- denotes )
T9054 3314-3316 IN denotes In
T9055 3317-3325 NN denotes addition
T9056 3325-3326 -COMMA- denotes ,
T9057 3327-3332 VB denotes using
T9058 3333-3345 JJ denotes GFP-labelled
T9059 3346-3352 NN denotes GATA-3
T9060 3353-3356 CC denotes and
T9061 3357-3365 JJ denotes confocal
T9062 3366-3376 NN denotes microscopy
T9063 3377-3379 PRP denotes we
T9064 3380-3392 VB denotes demonstrated
T9065 3393-3397 IN denotes that
T9066 3398-3404 NN denotes GATA-3
T9067 3405-3412 JJ denotes nuclear
T9068 3413-3419 NN denotes import
T9069 3420-3429 VB denotes following
T9070 3430-3443 JJ denotes anti-CD3/CD28
T9071 3444-3455 NN denotes stimulation
T9072 3456-3459 IN denotes for
T9073 3460-3462 CD denotes 30
T9074 3463-3466 NN denotes min
T9075 3467-3470 VB denotes was
T9076 3471-3481 VB denotes attenuated
T9077 3482-3484 IN denotes by
T9078 3485-3497 NN denotes pretreatment
T9079 3498-3502 IN denotes with
T9080 3503-3505 NN denotes FP
T9081 3506-3507 -LRB- denotes (
T9082 3507-3511 CD denotes 10−8
T9083 3512-3513 NN denotes M
T9084 3513-3514 -RRB- denotes )
T9085 3515-3516 -LRB- denotes (
T9086 3516-3522 NN denotes Figure
T9087 3523-3525 NN denotes 2D
T9088 3525-3526 -RRB- denotes )
T9702 5088-5094 NN denotes Effect
T9703 5095-5097 IN denotes on
T9704 5098-5103 NN denotes MKP-1
T9705 5104-5117 NN denotes Dexamethasone
T9706 5118-5126 VB denotes inhibits
T9707 5127-5130 NN denotes p38
T9708 5131-5135 NN denotes MAPK
T9709 5136-5144 NN denotes function
T9710 5145-5147 IN denotes in
T9711 5148-5149 DT denotes a
T9712 5150-5154 NN denotes cell
T9713 5155-5168 JJ denotes type–specific
T9714 5169-5175 NN denotes manner
T9715 5176-5183 IN denotes through
T9716 5184-5187 DT denotes the
T9717 5188-5193 JJ denotes rapid
T9718 5194-5203 NN denotes induction
T9719 5204-5206 IN denotes of
T9720 5207-5210 DT denotes the
T9721 5211-5215 JJ denotes dual
T9722 5216-5222 NN denotes kinase
T9723 5223-5234 NN denotes phosphatase
T9724 5235-5240 NN denotes MKP-1
T9725 5241-5242 -LRB- denotes (
T9726 5242-5246 NN denotes MAPK
T9727 5247-5260 NN denotes phosphatase-1
T9728 5260-5261 -RRB- denotes )
T9729 5261-5262 -COMMA- denotes ,
T9730 5263-5266 CC denotes and
T9731 5267-5271 DT denotes this
T9732 5272-5278 NN denotes effect
T9733 5279-5284 VB denotes lasts
T9734 5285-5288 IN denotes for
T9735 5289-5291 RB denotes up
T9736 5292-5294 TO denotes to
T9737 5295-5297 CD denotes 24
T9738 5298-5299 NN denotes h
T9739 5300-5301 -LRB- denotes [
T9740 5301-5303 CD denotes 28
T9741 5303-5304 -RRB- denotes ]
T9742 5306-5308 NN denotes FP
T9743 5309-5310 -LRB- denotes (
T9744 5310-5314 CD denotes 10−8
T9745 5315-5316 NN denotes M
T9746 5316-5317 -RRB- denotes )
T9747 5318-5327 NN denotes treatment
T9748 5328-5330 IN denotes of
T9749 5331-5337 NN denotes HuT-78
T9750 5338-5343 NN denotes cells
T9751 5344-5353 VB denotes activated
T9752 5354-5356 IN denotes by
T9753 5357-5370 JJ denotes anti-CD3/CD28
T9754 5371-5373 FW denotes in
T9755 5374-5379 FW denotes vitro
T9756 5380-5393 RB denotes significantly
T9757 5394-5403 VB denotes decreased
T9758 5404-5407 NN denotes p38
T9759 5408-5412 NN denotes MAPK
T9760 5413-5428 NN denotes phosphorylation
T9761 5429-5430 -LRB- denotes (
T9762 5430-5436 NN denotes Figure
T9763 5437-5439 NN denotes 3A
T9764 5439-5440 -RRB- denotes )
T9765 5441-5444 CC denotes and
T9766 5445-5453 NN denotes activity
T9767 5454-5462 VB denotes measured
T9768 5463-5465 IN denotes by
T9769 5466-5481 NN denotes phosphorylation
T9770 5482-5484 IN denotes of
T9771 5485-5488 DT denotes the
T9772 5489-5499 JJ denotes downstream
T9773 5500-5506 NN denotes target
T9774 5507-5512 NN denotes ATF-2
T9775 5513-5514 -LRB- denotes (
T9776 5514-5520 NN denotes Figure
T9777 5521-5523 NN denotes 3B
T9778 5523-5524 -RRB- denotes )
T9779 5526-5530 DT denotes This
T9780 5531-5537 NN denotes effect
T9781 5538-5541 VB denotes was
T9782 5542-5550 VB denotes detected
T9783 5551-5553 IN denotes at
T9784 5554-5556 CD denotes 30
T9785 5557-5560 NN denotes min
T9786 5561-5564 CC denotes and
T9787 5565-5571 VB denotes lasted
T9788 5572-5575 IN denotes for
T9789 5576-5578 IN denotes at
T9790 5579-5584 JJ denotes least
T9791 5585-5587 CD denotes 14
T9792 5588-5589 NN denotes h
T9793 5590-5591 -LRB- denotes (
T9794 5591-5597 NN denotes Figure
T9795 5598-5600 NN denotes 3B
T9796 5600-5601 -RRB- denotes )
T9797 5603-5605 NN denotes FP
T9798 5606-5607 -LRB- denotes (
T9799 5607-5611 CD denotes 10−8
T9800 5612-5613 NN denotes M
T9801 5613-5614 -RRB- denotes )
T9802 5615-5619 RB denotes also
T9803 5620-5633 RB denotes significantly
T9804 5634-5641 VB denotes reduced
T9805 5642-5648 NN denotes GATA-3
T9806 5649-5655 NN denotes serine
T9807 5656-5671 NN denotes phosphorylation
T9808 5672-5679 VB denotes induced
T9809 5680-5682 IN denotes by
T9810 5683-5696 JJ denotes anti-CD3/CD28
T9811 5697-5708 NN denotes stimulation
T9812 5709-5711 IN denotes in
T9813 5712-5716 CC denotes both
T9814 5717-5718 DT denotes a
T9815 5719-5724 NN denotes time-
T9816 5725-5728 CC denotes and
T9817 5729-5752 JJ denotes concentration-dependent
T9818 5753-5759 NN denotes manner
T9819 5760-5761 -LRB- denotes (
T9820 5761-5767 NN denotes Figure
T9821 5768-5770 NN denotes 3C
T9822 5770-5771 -RRB- denotes )
T9823 5773-5777 DT denotes This
T9824 5778-5787 NN denotes reduction
T9825 5788-5790 IN denotes in
T9826 5791-5797 NN denotes GATA-3
T9827 5798-5813 NN denotes phosphorylation
T9828 5814-5817 VB denotes was
T9829 5818-5822 RB denotes also
T9830 5823-5827 VB denotes seen
T9831 5828-5832 IN denotes with
T9832 5833-5838 JJ denotes lower
T9833 5839-5853 NN denotes concentrations
T9834 5854-5856 IN denotes of
T9835 5857-5859 NN denotes FP
T9836 5861-5863 PRP denotes We
T9837 5864-5869 VB denotes found
T9838 5870-5874 IN denotes that
T9839 5875-5877 NN denotes FP
T9840 5878-5891 RB denotes significantly
T9841 5892-5899 VB denotes induced
T9842 5900-5905 NN denotes MKP-1
T9843 5906-5910 NN denotes mRNA
T9844 5911-5913 IN denotes in
T9845 5914-5918 CC denotes both
T9846 5919-5920 DT denotes a
T9847 5921-5926 NN denotes time-
T9848 5927-5930 CC denotes and
T9849 5931-5954 JJ denotes concentration-dependent
T9850 5955-5961 NN denotes manner
T9851 5961-5962 -COMMA- denotes ,
T9852 5963-5971 VB denotes reaching
T9853 5972-5973 DT denotes a
T9854 5974-5981 NN denotes plateau
T9855 5982-5984 IN denotes at
T9856 5985-5989 CD denotes 10−8
T9857 5990-5991 NN denotes M
T9858 5992-5997 IN denotes after
T9859 5998-6000 CD denotes 10
T9860 6001-6004 NN denotes min
T9861 6005-6006 -LRB- denotes (
T9862 6006-6012 NN denotes Figure
T9863 6013-6015 NN denotes 3D
T9864 6016-6019 CC denotes and
T9865 6020-6022 NN denotes 3E
T9866 6022-6023 -RRB- denotes )
T9867 6025-6032 RB denotes However
T9868 6032-6033 -COMMA- denotes ,
T9869 6034-6037 DT denotes the
T9870 6038-6045 NN denotes effects
T9871 6046-6048 IN denotes of
T9872 6049-6051 NN denotes FP
T9873 6052-6054 IN denotes on
T9874 6055-6061 NN denotes GATA-3
T9875 6062-6069 JJ denotes nuclear
T9876 6070-6076 NN denotes import
T9877 6076-6077 -COMMA- denotes ,
T9878 6078-6088 JJ denotes importin-α
T9879 6089-6100 NN denotes association
T9880 6101-6104 CC denotes and
T9881 6105-6109 NN denotes IL-4
T9882 6110-6114 NN denotes mRNA
T9883 6115-6125 NN denotes expression
T9884 6126-6129 VB denotes are
T9885 6130-6134 VB denotes seen
T9886 6135-6137 IN denotes at
T9887 6138-6149 RB denotes 10,000-fold
T9888 6150-6155 JJ denotes lower
T9889 6156-6170 NN denotes concentrations
T9890 6171-6172 -LRB- denotes (
T9891 6172-6177 CD denotes 10−12
T9892 6178-6179 NN denotes M
T9893 6179-6180 -COMMA- denotes ,
T9894 6181-6184 VB denotes see
T9895 6185-6191 NN denotes Figure
T9896 6192-6193 CD denotes 2
T9897 6193-6194 -RRB- denotes )
T9898 7505-7510 VB denotes Using
T9899 7511-7513 DT denotes an
T9900 7514-7516 FW denotes in
T9901 7517-7522 FW denotes vitro
T9902 7523-7534 NN denotes competition
T9903 7535-7540 NN denotes assay
T9904 7541-7542 -LRB- denotes (
T9905 7542-7548 NN denotes Figure
T9906 7549-7551 NN denotes 4A
T9907 7551-7552 -RRB- denotes )
T9908 7553-7562 VB denotes utilizing
T9909 7563-7571 VB denotes purified
T9910 7572-7581 VB denotes activated
T9911 7582-7588 NN denotes GATA-3
T9912 7588-7589 -COMMA- denotes ,
T9913 7590-7600 NN denotes importin-α
T9914 7600-7601 -COMMA- denotes ,
T9915 7602-7605 CC denotes and
T9916 7606-7615 VB denotes activated
T9917 7616-7618 NN denotes GR
T9918 7618-7619 -COMMA- denotes ,
T9919 7620-7622 PRP denotes we
T9920 7623-7635 VB denotes demonstrated
T9921 7636-7640 IN denotes that
T9922 7641-7650 VB denotes activated
T9923 7651-7653 NN denotes GR
T9924 7654-7667 RB denotes significantly
T9925 7668-7677 VB denotes increased
T9926 7678-7691 JJ denotes GR-importin-α
T9927 7692-7703 NN denotes association
T9928 7704-7706 IN denotes in
T9929 7707-7710 DT denotes the
T9930 7711-7719 NN denotes presence
T9931 7720-7723 CC denotes and
T9932 7724-7731 NN denotes absence
T9933 7732-7734 IN denotes of
T9934 7735-7744 VB denotes activated
T9935 7745-7751 NN denotes GATA-3
T9936 7752-7753 -LRB- denotes (
T9937 7753-7759 NN denotes Figure
T9938 7760-7762 NN denotes 4B
T9939 7762-7763 -RRB- denotes )
T9940 7765-7769 DT denotes This
T9941 7770-7776 NN denotes effect
T9942 7777-7779 VB denotes is
T9943 7780-7783 RB denotes not
T9944 7784-7790 JJ denotes mutual
T9945 7790-7791 -COMMA- denotes ,
T9946 7792-7797 IN denotes since
T9947 7798-7807 VB denotes activated
T9948 7808-7814 NN denotes GATA-3
T9949 7815-7818 VB denotes did
T9950 7819-7822 RB denotes not
T9951 7823-7828 VB denotes block
T9952 7829-7842 JJ denotes GR–importin-α
T9953 7843-7854 NN denotes association
T9954 7855-7856 -LRB- denotes (
T9955 7856-7862 NN denotes Figure
T9956 7863-7865 NN denotes 4C
T9957 7865-7866 -RRB- denotes )
T9958 7868-7873 DT denotes These
T9959 7874-7878 NN denotes data
T9960 7879-7883 RB denotes also
T9961 7884-7891 VB denotes suggest
T9962 7892-7896 IN denotes that
T9963 7897-7901 CC denotes both
T9964 7902-7911 VB denotes activated
T9965 7912-7914 NN denotes GR
T9966 7915-7918 CC denotes and
T9967 7919-7933 NN denotes phospho-GATA-3
T9968 7934-7937 MD denotes can
T9969 7938-7946 RB denotes directly
T9970 7947-7956 VB denotes associate
T9971 7957-7961 IN denotes with
T9972 7962-7972 JJ denotes importin-α
T9973 7973-7974 -LRB- denotes (
T9974 7974-7980 NN denotes Figure
T9975 7981-7983 NN denotes 4D
T9976 7983-7984 -RRB- denotes )
T9977 7985-7988 CC denotes and
T9978 7989-7993 IN denotes that
T9979 7994-8003 VB denotes activated
T9980 8004-8006 NN denotes GR
T9981 8007-8017 VB denotes attenuates
T9982 8018-8021 DT denotes the
T9983 8022-8047 JJ denotes phospho-GATA-3/importin-α
T9984 8048-8059 NN denotes interaction
T9985 8060-8062 IN denotes in
T9986 8063-8064 DT denotes a
T9987 8065-8088 JJ denotes concentration-dependent
T9988 8089-8095 NN denotes manner
T9989 8096-8097 -LRB- denotes (
T9990 8097-8103 NN denotes Figure
T9991 8104-8106 NN denotes 4E
T9992 8106-8107 -RRB- denotes )
T9993 8109-8117 RB denotes Together
T9994 8117-8118 -COMMA- denotes ,
T9995 8119-8123 DT denotes this
T9996 8124-8132 VB denotes suggests
T9997 8133-8137 IN denotes that
T9998 8138-8154 JJ denotes ligand-activated
T9999 8155-8157 NN denotes GR
T10000 8158-8161 MD denotes may
T10001 8162-8169 VB denotes compete
T10002 8170-8174 IN denotes with
T10003 8175-8189 NN denotes phospho-GATA-3
T10004 8190-8193 IN denotes for
T10005 8194-8204 JJ denotes importin-α
T10006 8205-8208 CC denotes and
T10007 8209-8216 RB denotes thereby
T10008 8217-8222 VB denotes limit
T10009 8223-8229 NN denotes GATA-3
T10010 8230-8237 JJ denotes nuclear
T10011 8238-8244 NN denotes import
T10012 9334-9339 JJ denotes Other
T10013 9340-9348 JJ denotes possible
T10014 9349-9364 NN denotes interpretations
T10015 9365-9367 IN denotes of
T10016 9368-9371 PRP-DOLLAR- denotes our
T10017 9372-9379 NN denotes results
T10018 9380-9385 MD denotes could
T10019 9386-9393 VB denotes include
T10020 9394-9396 DT denotes an
T10021 9397-9403 NN denotes effect
T10022 9404-9406 IN denotes of
T10023 9407-9409 NN denotes FP
T10024 9410-9412 IN denotes on
T10025 9413-9419 NN denotes GATA-3
T10026 9420-9427 JJ denotes nuclear
T10027 9428-9434 NN denotes export
T10028 9435-9441 CC denotes and/or
T10029 9442-9453 NN denotes degradation
T10030 9455-9465 NNP denotes Leptomycin
T10031 9466-9467 NNP denotes B
T10032 9467-9468 -COMMA- denotes ,
T10033 9469-9474 WDT denotes which
T10034 9475-9483 VB denotes inhibits
T10035 9484-9491 JJ denotes nuclear
T10036 9492-9498 NN denotes export
T10037 9498-9499 -COMMA- denotes ,
T10038 9500-9503 VB denotes did
T10039 9504-9507 RB denotes not
T10040 9508-9514 VB denotes affect
T10041 9515-9518 DT denotes the
T10042 9519-9526 NN denotes ability
T10043 9527-9529 IN denotes of
T10044 9530-9532 NN denotes FP
T10045 9533-9535 TO denotes to
T10046 9536-9541 VB denotes block
T10047 9542-9548 NN denotes GATA-3
T10048 9549-9556 JJ denotes nuclear
T10049 9557-9569 NN denotes localization
T10050 9570-9571 -LRB- denotes (
T10051 9571-9577 NN denotes Figure
T10052 9578-9580 NN denotes 5A
T10053 9580-9581 -RRB- denotes )
T10054 9583-9595 RB denotes Additionally
T10055 9595-9596 -COMMA- denotes ,
T10056 9597-9599 NN denotes FP
T10057 9600-9603 VB denotes had
T10058 9604-9606 DT denotes no
T10059 9607-9613 NN denotes effect
T10060 9614-9616 IN denotes on
T10061 9617-9622 JJ denotes whole
T10062 9623-9627 NN denotes cell
T10063 9628-9634 NN denotes GATA-3
T10064 9635-9645 NN denotes expression
T10065 9646-9652 IN denotes during
T10066 9653-9656 DT denotes the
T10067 9657-9661 NN denotes time
T10068 9662-9668 NN denotes course
T10069 9669-9671 IN denotes of
T10070 9672-9677 DT denotes these
T10071 9678-9689 NN denotes experiments
T10072 9690-9691 -LRB- denotes (
T10073 9691-9697 NN denotes Figure
T10074 9698-9700 NN denotes 5B
T10075 9700-9701 -RRB- denotes )
T10076 9703-9706 CC denotes Nor
T10077 9707-9710 VB denotes did
T10078 9711-9719 NN denotes addition
T10079 9720-9722 IN denotes of
T10080 9723-9725 NN denotes FP
T10081 9726-9736 JJ denotes subsequent
T10082 9737-9739 TO denotes to
T10083 9740-9753 JJ denotes anti-CD3/CD28
T10084 9754-9761 JJ denotes nuclear
T10085 9762-9775 NN denotes translocation
T10086 9776-9782 VB denotes affect
T10087 9783-9789 NN denotes GATA-3
T10088 9790-9797 JJ denotes nuclear
T10089 9798-9807 NN denotes residency
T10090 9808-9809 -LRB- denotes (
T10091 9809-9815 NN denotes Figure
T10092 9816-9818 NN denotes 5C
T10093 9818-9819 -RRB- denotes )
T10094 9819-9820 -COMMA- denotes ,
T10095 9821-9831 VB denotes suggesting
T10096 9832-9836 IN denotes that
T10097 9837-9846 VB denotes activated
T10098 9847-9849 NN denotes GR
T10099 9850-9854 VB denotes does
T10100 9855-9858 RB denotes not
T10101 9859-9866 VB denotes enhance
T10102 9867-9873 NN denotes GATA-3
T10103 9874-9881 JJ denotes nuclear
T10104 9882-9888 NN denotes export
T10105 9890-9897 RB denotes Finally
T10106 9897-9898 -COMMA- denotes ,
T10107 9899-9902 DT denotes the
T10108 9903-9909 NN denotes effect
T10109 9910-9912 IN denotes of
T10110 9913-9915 NN denotes FP
T10111 9916-9918 IN denotes on
T10112 9919-9925 NN denotes GATA-3
T10113 9926-9933 JJ denotes nuclear
T10114 9934-9940 NN denotes import
T10115 9941-9944 VB denotes was
T10116 9945-9948 RB denotes not
T10117 9949-9960 JJ denotes nonspecific
T10118 9960-9961 -COMMA- denotes ,
T10119 9962-9967 IN denotes since
T10120 9968-9970 NN denotes FP
T10121 9971-9972 -LRB- denotes (
T10122 9972-9976 CD denotes 10−8
T10123 9977-9978 NN denotes M
T10124 9978-9979 -RRB- denotes )
T10125 9980-9983 VB denotes had
T10126 9984-9986 DT denotes no
T10127 9987-9993 NN denotes effect
T10128 9994-9996 IN denotes on
T10129 9997-10000 NN denotes p65
T10130 10001-10008 JJ denotes nuclear
T10131 10009-10022 NN denotes translocation
T10132 10023-10031 VB denotes measured
T10133 10032-10034 IN denotes at
T10134 10035-10037 CD denotes 60
T10135 10038-10041 NN denotes min
T10136 10042-10043 -LRB- denotes (
T10137 10043-10049 NN denotes Figure
T10138 10050-10052 NN denotes 5D
T10139 10052-10053 -RRB- denotes )
T11309 11106-11109 DT denotes The
T11310 11110-11120 JJ denotes Inhibitory
T11311 11121-11127 NN denotes Effect
T11312 11128-11130 IN denotes of
T11313 11131-11146 NN denotes Corticosteroids
T11314 11147-11149 IN denotes on
T11315 11150-11156 NN denotes GATA-3
T11316 11157-11164 JJ denotes Nuclear
T11317 11165-11177 NN denotes Localization
T11318 11178-11180 IN denotes in
T11319 11181-11188 JJ denotes Primary
T11320 11189-11190 NN denotes T
T11321 11191-11202 NN denotes Lymphocytes
T11322 11203-11205 NNP denotes Ex
T11323 11206-11210 NNP denotes Vivo
T11324 11211-11214 CC denotes and
T11325 11215-11217 IN denotes In
T11326 11218-11222 FW denotes Vivo
T11327 11223-11232 NN denotes Treatment
T11328 11233-11237 IN denotes with
T11329 11238-11240 NN denotes FP
T11330 11241-11243 FW denotes ex
T11331 11244-11248 FW denotes vivo
T11332 11249-11261 VB denotes demonstrated
T11333 11262-11263 DT denotes a
T11334 11264-11287 JJ denotes concentration-dependent
T11335 11288-11296 NN denotes decrease
T11336 11297-11299 IN denotes in
T11337 11300-11303 DT denotes the
T11338 11304-11310 JJ denotes direct
T11339 11311-11322 NN denotes interaction
T11340 11323-11330 IN denotes between
T11341 11331-11345 NN denotes phospho-GATA-3
T11342 11346-11349 CC denotes and
T11343 11350-11360 NN denotes importin-α
T11344 11361-11363 IN denotes in
T11345 11364-11369 NN denotes PBMCs
T11346 11370-11374 IN denotes from
T11347 11375-11383 NN denotes patients
T11348 11384-11388 IN denotes with
T11349 11389-11395 NN denotes asthma
T11350 11396-11397 -LRB- denotes (
T11351 11397-11403 NN denotes Figure
T11352 11404-11406 NN denotes 6A
T11353 11407-11410 CC denotes and
T11354 11411-11413 NN denotes 6B
T11355 11413-11414 -RRB- denotes )
T11356 11414-11415 -COMMA- denotes ,
T11357 11416-11421 WDT denotes which
T11358 11422-11425 VB denotes was
T11359 11426-11439 RB denotes significantly
T11360 11440-11449 VB denotes inhibited
T11361 11450-11452 IN denotes at
T11362 11453-11458 CD denotes 10−12
T11363 11459-11460 NN denotes M
T11364 11461-11463 NN denotes FP
T11365 11464-11465 -LRB- denotes (
T11366 11465-11466 NN denotes p
T11367 11466-11467 JJ denotes <
T11368 11467-11472 CD denotes 0.001
T11369 11472-11473 -COMMA- denotes ,
T11370 11474-11479 NN denotes ANOVA
T11371 11480-11483 CC denotes and
T11372 11484-11496 NNP denotes Newman-Keuls
T11373 11497-11501 NN denotes test
T11374 11501-11502 -RRB- denotes )
T11375 11503-11506 CC denotes and
T11376 11507-11517 RB denotes completely
T11377 11518-11528 VB denotes attenuated
T11378 11529-11531 IN denotes by
T11379 11532-11536 CD denotes 10−8
T11380 11537-11538 NN denotes M
T11381 11539-11541 NN denotes FP
T11382 11542-11543 -LRB- denotes (
T11383 11543-11544 NN denotes p
T11384 11544-11545 JJ denotes <
T11385 11545-11550 CD denotes 0.001
T11386 11550-11551 -COMMA- denotes ,
T11387 11552-11557 NN denotes ANOVA
T11388 11558-11561 CC denotes and
T11389 11562-11574 NNP denotes Newman-Keuls
T11390 11575-11579 NN denotes test
T11391 11579-11580 -RRB- denotes )
T11392 12531-12534 PRP-DOLLAR- denotes Our
T11393 12535-12543 JJ denotes previous
T11394 12544-12545 NN denotes T
T11395 12546-12550 NN denotes cell
T11396 12551-12555 NN denotes line
T11397 12556-12563 NN denotes studies
T11398 12564-12573 VB denotes indicated
T11399 12574-12578 IN denotes that
T11400 12579-12584 CD denotes 10−12
T11401 12585-12586 NN denotes M
T11402 12587-12589 NN denotes FP
T11403 12590-12600 VB denotes suppresses
T11404 12601-12605 NN denotes IL-4
T11405 12606-12609 CC denotes and
T11406 12610-12612 CD denotes -5
T11407 12613-12617 NN denotes gene
T11408 12618-12628 NN denotes expression
T11409 12629-12632 CC denotes and
T11410 12633-12643 VB denotes attenuated
T11411 12644-12647 DT denotes the
T11412 12648-12659 NN denotes interaction
T11413 12660-12662 IN denotes of
T11414 12663-12669 NN denotes GATA-3
T11415 12670-12674 IN denotes with
T11416 12675-12685 NN denotes importin-α
T11417 12686-12687 -LRB- denotes (
T11418 12687-12690 VB denotes see
T11419 12691-12698 NN denotes Figures
T11420 12699-12701 NN denotes 1D
T11421 12702-12705 CC denotes and
T11422 12706-12707 CD denotes 2
T11423 12707-12708 -RRB- denotes )
T11424 12710-12714 DT denotes This
T11425 12715-12728 NN denotes concentration
T11426 12729-12731 VB denotes is
T11427 12732-12737 JJ denotes close
T11428 12738-12740 TO denotes to
T11429 12741-12745 JJ denotes peak
T11430 12746-12752 NN denotes plasma
T11431 12753-12759 NN denotes levels
T11432 12760-12768 VB denotes obtained
T11433 12769-12773 IN denotes from
T11434 12774-12783 JJ denotes asthmatic
T11435 12784-12792 NN denotes patients
T11436 12793-12800 VB denotes treated
T11437 12801-12805 IN denotes with
T11438 12806-12813 VB denotes inhaled
T11439 12814-12816 NN denotes FP
T11440 12817-12818 -LRB- denotes (
T11441 12818-12821 CD denotes 500
T11442 12822-12824 NN denotes µg
T11443 12824-12825 -RRB- denotes )
T11444 12826-12827 -LRB- denotes [
T11445 12827-12829 CD denotes 27
T11446 12829-12830 -RRB- denotes ]
T11447 12832-12839 VB denotes Inhaled
T11448 12840-12842 NN denotes FP
T11449 12843-12844 -LRB- denotes (
T11450 12844-12847 CD denotes 500
T11451 12848-12850 NN denotes µg
T11452 12850-12851 -RRB- denotes )
T11453 12852-12861 NN denotes treatment
T11454 12862-12864 IN denotes of
T11455 12865-12870 CD denotes seven
T11456 12871-12884 JJ denotes steroid-naive
T11457 12885-12891 NN denotes asthma
T11458 12892-12900 NN denotes patients
T11459 12901-12914 RB denotes significantly
T11460 12915-12922 VB denotes reduced
T11461 12923-12940 NN denotes GATA-3–importin-α
T11462 12941-12952 NN denotes interaction
T11463 12953-12955 FW denotes in
T11464 12956-12960 FW denotes vivo
T11465 12961-12963 IN denotes in
T11466 12964-12965 DT denotes a
T11467 12966-12980 JJ denotes time-dependent
T11468 12981-12987 NN denotes manner
T11469 12989-12993 DT denotes This
T11470 12994-13002 VB denotes produced
T11471 13003-13004 DT denotes a
T11472 13005-13006 JJ denotes >
T11473 13006-13008 CD denotes 90
T11474 13008-13009 NN denotes %
T11475 13010-13018 NN denotes decrease
T11476 13019-13021 IN denotes in
T11477 13022-13039 NN denotes GATA-3–importin-α
T11478 13040-13051 NN denotes association
T11479 13052-13054 IN denotes at
T11480 13055-13056 CD denotes 2
T11481 13057-13058 NN denotes h
T11482 13059-13060 -LRB- denotes (
T11483 13060-13066 NN denotes median
T11484 13067-13068 -LRB- denotes [
T11485 13068-13070 CD denotes 95
T11486 13070-13071 NN denotes %
T11487 13072-13074 NN denotes CI
T11488 13074-13075 -RRB- denotes ]
T11489 13075-13076 -COMMA- denotes ,
T11490 13077-13083 CD denotes 13,494
T11491 13084-13085 -LRB- denotes [
T11492 13085-13097 CD denotes 6,828–17,829
T11493 13097-13098 -RRB- denotes ]
T11494 13099-13105 IN denotes versus
T11495 13106-13109 CD denotes 879
T11496 13110-13111 -LRB- denotes [
T11497 13111-13120 CD denotes 597–1,165
T11498 13120-13121 -RRB- denotes ]
T11499 13121-13122 -COLON- denotes ;
T11500 13123-13124 NN denotes p
T11501 13124-13125 SYM denotes <
T11502 13125-13129 CD denotes 0.05
T11503 13130-13138 NNP denotes Friedman
T11504 13138-13140 POS denotes 's
T11505 13141-13149 NN denotes analysis
T11506 13149-13150 -RRB- denotes )
T11507 13152-13159 RB denotes However
T11508 13159-13160 -COMMA- denotes ,
T11509 13161-13165 DT denotes this
T11510 13166-13169 VB denotes did
T11511 13170-13173 RB denotes not
T11512 13174-13179 VB denotes reach
T11513 13180-13192 NN denotes significance
T11514 13193-13198 VB denotes using
T11515 13199-13207 NNP denotes Wilcoxon
T11516 13207-13209 POS denotes 's
T11517 13210-13219 JJ denotes post-test
T11518 13220-13228 NN denotes analysis
T11519 13229-13230 -LRB- denotes (
T11520 13230-13238 NN denotes W = 6.00
T11521 13238-13239 -RRB- denotes )
T11522 13240-13248 RB denotes probably
T11523 13249-13252 JJ denotes due
T11524 13253-13255 TO denotes to
T11525 13256-13259 JJ denotes low
T11526 13260-13267 NN denotes numbers
T11527 13268-13270 IN denotes of
T11528 13271-13283 NN denotes participants
T11529 13285-13292 JJ denotes Similar
T11530 13293-13300 NN denotes results
T11531 13301-13305 VB denotes were
T11532 13306-13314 VB denotes observed
T11533 13315-13319 WRB denotes when
T11534 13320-13337 NN denotes GATA-3–importin-α
T11535 13338-13349 NN denotes association
T11536 13350-13353 VB denotes was
T11537 13354-13362 VB denotes measured
T11538 13363-13364 -LRB- denotes (
T11539 13364-13370 NN denotes Figure
T11540 13371-13373 NN denotes 6C
T11541 13374-13377 CC denotes and
T11542 13378-13380 NN denotes 6D
T11543 13380-13381 -RRB- denotes )
T11544 13383-13386 DT denotes The
T11545 13387-13392 JJ denotes lower
T11546 13393-13397 NN denotes dose
T11547 13398-13400 IN denotes of
T11548 13401-13403 NN denotes FP
T11549 13404-13405 -LRB- denotes (
T11550 13405-13408 CD denotes 100
T11551 13409-13411 NN denotes µg
T11552 13411-13412 -RRB- denotes )
T11553 13413-13416 VB denotes was
T11554 13417-13420 RB denotes not
T11555 13421-13430 JJ denotes effective
T11556 13432-13435 DT denotes The
T11557 13436-13446 JJ denotes attenuated
T11558 13447-13458 NN denotes interaction
T11559 13459-13461 IN denotes of
T11560 13462-13468 NN denotes GATA-3
T11561 13469-13472 VB denotes did
T11562 13473-13476 RB denotes not
T11563 13477-13483 VB denotes result
T11564 13484-13488 IN denotes from
T11565 13489-13492 DT denotes the
T11566 13493-13502 JJ denotes defective
T11567 13503-13512 NN denotes recycling
T11568 13513-13515 IN denotes of
T11569 13516-13526 NN denotes importin-α
T11570 13526-13527 -COMMA- denotes ,
T11571 13528-13530 IN denotes as
T11572 13531-13532 DT denotes a
T11573 13533-13544 JJ denotes significant
T11574 13545-13553 NN denotes decrease
T11575 13554-13556 IN denotes in
T11576 13557-13560 DT denotes the
T11577 13561-13570 NN denotes abundance
T11578 13571-13573 IN denotes of
T11579 13574-13584 NN denotes importin-α
T11580 13585-13587 IN denotes in
T11581 13588-13591 DT denotes the
T11582 13592-13603 JJ denotes cytoplasmic
T11583 13604-13608 NN denotes pool
T11584 13609-13612 VB denotes was
T11585 13613-13616 RB denotes not
T11586 13617-13625 VB denotes detected
T11587 13626-13627 -LRB- denotes (
T11588 13627-13633 NN denotes Figure
T11589 13634-13636 NN denotes 6E
T11590 13636-13637 -RRB- denotes )
T11591 13639-13641 PRP denotes We
T11592 13642-13649 RB denotes further
T11593 13650-13658 VB denotes examined
T11594 13659-13666 IN denotes whether
T11595 13667-13674 VB denotes inhaled
T11596 13675-13677 NN denotes FP
T11597 13678-13683 MD denotes could
T11598 13684-13690 VB denotes affect
T11599 13691-13699 JJ denotes cellular
T11600 13700-13712 NN denotes localization
T11601 13713-13715 IN denotes of
T11602 13716-13722 NN denotes GATA-3
T11603 13723-13725 IN denotes in
T11604 13726-13736 JJ denotes peripheral
T11605 13737-13742 NN denotes blood
T11606 13743-13744 NN denotes T
T11607 13745-13750 NN denotes cells
T11608 13752-13761 NN denotes Treatment
T11609 13762-13766 IN denotes with
T11610 13767-13774 VB denotes inhaled
T11611 13775-13777 NN denotes FP
T11612 13778-13779 -LRB- denotes (
T11613 13779-13782 CD denotes 500
T11614 13783-13785 NN denotes µg
T11615 13785-13786 -RRB- denotes )
T11616 13787-13790 IN denotes for
T11617 13791-13792 CD denotes 2
T11618 13793-13794 NN denotes h
T11619 13795-13808 RB denotes significantly
T11620 13809-13818 VB denotes increased
T11621 13819-13821 NN denotes GR
T11622 13822-13829 JJ denotes nuclear
T11623 13830-13843 NN denotes translocation
T11624 13844-13845 -LRB- denotes (
T11625 13845-13851 NN denotes Figure
T11626 13852-13854 NN denotes 7A
T11627 13854-13855 -RRB- denotes )
T11628 13856-13859 CC denotes and
T11629 13860-13873 RB denotes concomitantly
T11630 13874-13883 VB denotes decreased
T11631 13884-13887 DT denotes the
T11632 13888-13894 NN denotes number
T11633 13895-13897 IN denotes of
T11634 13898-13905 JJ denotes nuclear
T11635 13906-13912 NN denotes GATA-3
T11636 13913-13927 JJ denotes immunoreactive
T11637 13928-13938 JJ denotes peripheral
T11638 13939-13944 NN denotes blood
T11639 13945-13946 NN denotes T
T11640 13947-13952 NN denotes cells
T11641 13953-13954 -LRB- denotes (
T11642 13954-13956 CD denotes 37
T11643 13956-13957 NN denotes %
T11644 13957-13961 CD denotes ±4.2
T11645 13961-13962 NN denotes %
T11646 13963-13969 IN denotes versus
T11647 13970-13974 CD denotes 58.2
T11648 13974-13975 NN denotes %
T11649 13975-13980 CD denotes ±4.95
T11650 13980-13981 NN denotes %
T11651 13981-13982 -COMMA- denotes ,
T11652 13983-13992 NN denotes p = 0.016
T11653 13992-13993 -COMMA- denotes ,
T11654 13994-14002 NN denotes W = 28.0
T11655 14002-14003 -COMMA- denotes ,
T11656 14004-14012 NNP denotes Wilcoxon
T11657 14012-14014 POS denotes 's
T11658 14015-14019 NN denotes rank
T11659 14020-14024 NN denotes test
T11660 14024-14025 -RRB- denotes )
T11661 14026-14034 VB denotes compared
T11662 14035-14039 IN denotes with
T11663 14040-14047 NN denotes placebo
T11664 14048-14050 IN denotes as
T11665 14051-14059 VB denotes measured
T11666 14060-14062 IN denotes by
T11667 14063-14082 NN denotes immunocytochemistry
T11668 14083-14084 -LRB- denotes (
T11669 14084-14090 NN denotes Figure
T11670 14091-14093 NN denotes 7A
T11671 14094-14097 CC denotes and
T11672 14098-14100 NN denotes 7B
T11673 14100-14101 -RRB- denotes )
T11674 14103-14107 DT denotes This
T11675 14108-14111 VB denotes was
T11676 14112-14121 VB denotes confirmed
T11677 14122-14124 IN denotes by
T11678 14125-14132 JJ denotes Western
T11679 14133-14141 NN denotes blotting
T11680 14141-14142 -COMMA- denotes ,
T11681 14143-14148 WDT denotes which
T11682 14149-14153 RB denotes also
T11683 14154-14163 VB denotes indicated
T11684 14164-14168 IN denotes that
T11685 14169-14173 DT denotes this
T11686 14174-14180 NN denotes effect
T11687 14181-14184 VB denotes was
T11688 14185-14189 CC denotes both
T11689 14190-14195 NN denotes time-
T11690 14196-14199 CC denotes and
T11691 14200-14214 JJ denotes dose-dependent
T11692 14215-14216 -LRB- denotes (
T11693 14216-14222 NN denotes Figure
T11694 14223-14225 NN denotes 7C
T11695 14226-14229 CC denotes and
T11696 14230-14232 NN denotes 7D
T11697 14232-14233 -RRB- denotes )
T11698 14235-14239 RB denotes Thus
T11699 14239-14240 -COMMA- denotes ,
T11700 14241-14248 VB denotes inhaled
T11701 14249-14251 NN denotes FP
T11702 14252-14253 -LRB- denotes (
T11703 14253-14256 CD denotes 500
T11704 14257-14259 NN denotes µg
T11705 14259-14260 -RRB- denotes )
T11706 14261-14268 VB denotes induced
T11707 14269-14280 JJ denotes significant
T11708 14281-14285 NN denotes loss
T11709 14286-14288 IN denotes in
T11710 14289-14296 JJ denotes nuclear
T11711 14297-14303 NN denotes GATA-3
T11712 14304-14306 IN denotes at
T11713 14307-14308 CD denotes 2
T11714 14309-14310 NN denotes h
T11715 14311-14312 -LRB- denotes (
T11716 14312-14318 NN denotes median
T11717 14319-14320 -LRB- denotes [
T11718 14320-14322 CD denotes 95
T11719 14322-14323 NN denotes %
T11720 14324-14326 NN denotes CI
T11721 14326-14327 -RRB- denotes ]
T11722 14327-14328 -COMMA- denotes ,
T11723 14329-14333 CD denotes 0.40
T11724 14334-14335 -LRB- denotes [
T11725 14335-14344 CD denotes 0.27–0.53
T11726 14344-14345 -RRB- denotes ]
T11727 14346-14352 IN denotes versus
T11728 14353-14357 CD denotes 0.14
T11729 14358-14359 -LRB- denotes [
T11730 14359-14368 CD denotes 0.11–0.19
T11731 14368-14369 -RRB- denotes ]
T11732 14369-14370 -COMMA- denotes ,
T11733 14371-14372 NN denotes p
T11734 14372-14373 SYM denotes <
T11735 14373-14377 CD denotes 0.05
T11736 14377-14378 -COMMA- denotes ,
T11737 14379-14388 NN denotes W = 21.00
T11738 14388-14389 -COMMA- denotes ,
T11739 14390-14398 NNP denotes Wilcoxon
T11740 14398-14400 POS denotes 's
T11741 14401-14405 NN denotes rank
T11742 14406-14410 NN denotes test
T11743 14410-14411 -RRB- denotes )
T11744 14412-14413 -LRB- denotes (
T11745 14413-14419 NN denotes Figure
T11746 14420-14422 NN denotes 7C
T11747 14422-14423 -RRB- denotes )
T11748 14424-14427 CC denotes and
T11749 14428-14439 JJ denotes cytoplasmic
T11750 14440-14446 NN denotes GATA-3
T11751 14447-14453 NN denotes levels
T11752 14454-14458 VB denotes were
T11753 14459-14467 VB denotes enhanced
T11754 14468-14470 IN denotes by
T11755 14471-14478 VB denotes inhaled
T11756 14479-14481 NN denotes FP
T11757 14482-14484 IN denotes in
T11758 14485-14486 DT denotes a
T11759 14487-14501 JJ denotes dose-dependent
T11760 14502-14508 NN denotes manner
T11761 14509-14510 -LRB- denotes (
T11762 14510-14516 NN denotes median
T11763 14517-14518 -LRB- denotes [
T11764 14518-14520 CD denotes 95
T11765 14520-14521 NN denotes %
T11766 14522-14524 NN denotes CI
T11767 14524-14525 -RRB- denotes ]
T11768 14525-14526 -COMMA- denotes ,
T11769 14527-14533 CD denotes 0.0032
T11770 14534-14535 -LRB- denotes [
T11771 14535-14548 CD denotes 0.0026–0.0039
T11772 14548-14549 -RRB- denotes ]
T11773 14550-14556 IN denotes versus
T11774 14557-14562 CD denotes 0.658
T11775 14563-14564 -LRB- denotes [
T11776 14564-14575 CD denotes 0.592–0.720
T11777 14575-14576 -RRB- denotes ]
T11778 14576-14577 -COMMA- denotes ,
T11779 14578-14579 NN denotes p
T11780 14579-14580 SYM denotes <
T11781 14580-14584 CD denotes 0.05
T11782 14584-14585 -COMMA- denotes ,
T11783 14586-14596 NN denotes W = −21.00
T11784 14596-14597 -COMMA- denotes ,
T11785 14598-14606 NNP denotes Wilcoxon
T11786 14606-14608 POS denotes 's
T11787 14609-14613 NN denotes rank
T11788 14614-14618 NN denotes test
T11789 14618-14619 -RRB- denotes )
T11790 14620-14621 -LRB- denotes (
T11791 14621-14627 NN denotes Figure
T11792 14628-14630 NN denotes 7D
T11793 14630-14631 -RRB- denotes )
T11794 14633-14635 IN denotes In
T11795 14636-14644 NN denotes addition
T11796 14644-14645 -COMMA- denotes ,
T11797 14646-14648 NN denotes FP
T11798 14649-14650 -LRB- denotes (
T11799 14650-14653 CD denotes 500
T11800 14654-14656 NN denotes µg
T11801 14656-14657 -RRB- denotes )
T11802 14658-14667 VB denotes inhibited
T11803 14668-14671 NN denotes p38
T11804 14672-14676 NN denotes MAPK
T11805 14677-14692 NN denotes phosphorylation
T11806 14693-14695 IN denotes in
T11807 14696-14703 JJ denotes primary
T11808 14704-14705 NN denotes T
T11809 14706-14711 NN denotes cells
T11810 14712-14714 FW denotes in
T11811 14715-14719 FW denotes vivo
T11812 14720-14722 IN denotes at
T11813 14723-14724 CD denotes 2
T11814 14725-14726 NN denotes h
T11815 14727-14729 IN denotes in
T11816 14730-14737 NN denotes samples
T11817 14738-14742 IN denotes from
T11818 14743-14746 CD denotes two
T11819 14747-14755 NN denotes patients
T11820 14756-14757 -LRB- denotes (
T11821 14757-14763 NN denotes Figure
T11822 14764-14766 NN denotes 7E
T11823 14766-14767 -RRB- denotes )
T11824 16255-16260 VB denotes Taken
T11825 16261-16269 RB denotes together
T11826 16269-16270 -COMMA- denotes ,
T11827 16271-16274 PRP-DOLLAR- denotes our
T11828 16275-16279 NN denotes data
T11829 16280-16287 VB denotes suggest
T11830 16288-16292 IN denotes that
T11831 16293-16300 VB denotes inhaled
T11832 16301-16303 NN denotes FP
T11833 16304-16311 VB denotes reduces
T11834 16312-16319 JJ denotes nuclear
T11835 16320-16332 NN denotes localization
T11836 16333-16335 IN denotes of
T11837 16336-16342 NN denotes GATA-3
T11838 16343-16345 FW denotes in
T11839 16346-16350 FW denotes vivo
T11840 16351-16353 IN denotes by
T11841 16354-16361 RB denotes acutely
T11842 16362-16372 VB denotes inhibiting
T11843 16373-16396 NN denotes phospho-GATA-3–importin
T11844 16397-16408 NN denotes association
T11845 16410-16414 DT denotes This
T11846 16415-16421 NN denotes effect
T11847 16422-16425 MD denotes may
T11848 16426-16428 VB denotes be
T11849 16429-16435 JJ denotes direct
T11850 16435-16436 -COMMA- denotes ,
T11851 16437-16444 IN denotes through
T11852 16445-16456 NN denotes competition
T11853 16457-16460 IN denotes for
T11854 16461-16471 JJ denotes importin-α
T11855 16472-16474 CC denotes or
T11856 16475-16485 VB denotes associated
T11857 16486-16495 NN denotes molecules
T11858 16495-16496 -COMMA- denotes ,
T11859 16497-16499 CC denotes or
T11860 16500-16509 JJ denotes secondary
T11861 16510-16512 TO denotes to
T11862 16513-16515 DT denotes an
T11863 16516-16522 NN denotes effect
T11864 16523-16525 IN denotes on
T11865 16526-16529 NN denotes p38
T11866 16530-16543 JJ denotes MAPK-mediated
T11867 16544-16550 NN denotes GATA-3
T11868 16551-16566 NN denotes phosphorylation
T11869 16567-16570 IN denotes via
T11870 16571-16576 JJ denotes rapid
T11871 16577-16586 NN denotes induction
T11872 16587-16589 IN denotes of
T11873 16590-16595 NN denotes MKP-1
T11874 16597-16600 DT denotes The
T11875 16601-16612 NN denotes combination
T11876 16613-16615 IN denotes of
T11877 16616-16621 DT denotes these
T11878 16622-16625 CD denotes two
T11879 16626-16637 VB denotes interacting
T11880 16638-16645 NN denotes effects
T11881 16646-16649 MD denotes can
T11882 16650-16656 VB denotes result
T11883 16657-16659 IN denotes in
T11884 16660-16668 JJ denotes complete
T11885 16669-16680 NN denotes suppression
T11886 16681-16683 IN denotes of
T11887 16684-16690 NN denotes GATA-3
T11888 16691-16698 JJ denotes nuclear
T11889 16699-16705 NN denotes import
T11890 16706-16709 CC denotes and
T11891 16710-16714 RB denotes thus
T11892 16715-16718 NN denotes Th2
T11893 16719-16727 NN denotes cytokine
T11894 16728-16732 NN denotes gene
T11895 16733-16743 NN denotes expression
T16038 1156-1167 NN denotes Fluticasone
T16039 1168-1178 NN denotes propionate
T16040 1179-1193 VB denotes down-regulates
T16041 1194-1197 NN denotes Th2
T16042 1198-1206 NN denotes cytokine
T16043 1207-1211 NN denotes gene
T16044 1212-1222 NN denotes expression
T16045 1223-1226 CC denotes and
T16046 1227-1235 VB denotes inhibits
T16047 1236-1242 NN denotes GATA-3
T16048 1243-1250 JJ denotes nuclear
T16049 1251-1257 NN denotes import
T16050 1259-1260 -LRB- denotes (
T16051 1260-1261 NN denotes A
T16052 1261-1262 -RRB- denotes )
T16053 1263-1276 JJ denotes Anti-CD3/CD28
T16054 1277-1286 NN denotes treatment
T16055 1287-1289 IN denotes of
T16056 1290-1296 NN denotes HuT-78
T16057 1297-1302 NN denotes cells
T16058 1303-1310 VB denotes results
T16059 1311-1313 IN denotes in
T16060 1314-1327 NN denotes translocation
T16061 1328-1330 IN denotes of
T16062 1331-1337 NN denotes GATA-3
T16063 1338-1342 IN denotes from
T16064 1343-1346 DT denotes the
T16065 1347-1356 NN denotes cytoplasm
T16066 1357-1359 TO denotes to
T16067 1360-1363 DT denotes the
T16068 1364-1371 NN denotes nucleus
T16069 1372-1378 IN denotes within
T16070 1379-1381 CD denotes 30
T16071 1382-1386 NN denotes min.
T16072 1387-1388 -LRB- denotes (
T16073 1388-1389 NN denotes B
T16074 1389-1390 -RRB- denotes )
T16075 1391-1398 NN denotes Histone
T16076 1399-1401 NN denotes H1
T16077 1402-1405 CC denotes and
T16078 1406-1411 NN denotes MEK-1
T16079 1412-1416 VB denotes were
T16080 1417-1421 VB denotes used
T16081 1422-1424 TO denotes to
T16082 1425-1432 VB denotes confirm
T16083 1433-1441 JJ denotes distinct
T16084 1442-1452 NN denotes separation
T16085 1453-1455 IN denotes of
T16086 1456-1467 JJ denotes cytoplasmic
T16087 1468-1471 CC denotes and
T16088 1472-1479 JJ denotes nuclear
T16089 1480-1488 NN denotes extracts
T16090 1489-1491 IN denotes in
T16091 1492-1497 CD denotes three
T16092 1498-1506 JJ denotes separate
T16093 1507-1519 NN denotes experiments.
T16094 1520-1521 -LRB- denotes (
T16095 1521-1522 NN denotes C
T16096 1522-1523 -RRB- denotes )
T16097 1524-1531 JJ denotes Western
T16098 1532-1536 NN denotes blot
T16099 1537-1545 NN denotes analysis
T16100 1546-1548 IN denotes of
T16101 1549-1559 JJ denotes FP-treated
T16102 1560-1566 NN denotes HuT-78
T16103 1567-1572 NN denotes cells
T16104 1573-1585 VB denotes demonstrated
T16105 1586-1594 JJ denotes impaired
T16106 1595-1602 JJ denotes nuclear
T16107 1603-1615 NN denotes localization
T16108 1616-1618 IN denotes of
T16109 1619-1625 NN denotes GATA-3
T16110 1626-1633 VB denotes induced
T16111 1634-1636 IN denotes by
T16112 1637-1650 JJ denotes anti-CD3/CD28
T16113 1651-1665 NN denotes co-stimulation
T16114 1666-1668 IN denotes in
T16115 1669-1670 DT denotes a
T16116 1671-1676 NN denotes time-
T16117 1677-1678 -LRB- denotes (
T16118 1678-1680 IN denotes at
T16119 1681-1685 CD denotes 10−8
T16120 1686-1687 NN denotes M
T16121 1688-1690 NN denotes FP
T16122 1690-1691 -RRB- denotes )
T16123 1692-1695 CC denotes and
T16124 1696-1710 NN denotes concentration-
T16125 1711-1712 -LRB- denotes (
T16126 1712-1714 IN denotes at
T16127 1715-1717 CD denotes 60
T16128 1718-1721 NN denotes min
T16129 1722-1727 IN denotes after
T16130 1728-1739 NN denotes stimulation
T16131 1739-1740 -RRB- denotes )
T16132 1741-1750 JJ denotes dependent
T16133 1751-1757 NN denotes manner
T16134 1759-1764 NN denotes Cells
T16135 1765-1769 VB denotes were
T16136 1770-1780 VB denotes pretreated
T16137 1781-1785 IN denotes with
T16138 1786-1788 NN denotes FP
T16139 1789-1792 IN denotes for
T16140 1793-1795 CD denotes 30
T16141 1796-1799 NN denotes min
T16142 1800-1805 JJ denotes prior
T16143 1806-1808 TO denotes to
T16144 1809-1820 NN denotes stimulation
T16145 1822-1826 NN denotes MEK1
T16146 1827-1830 CC denotes and
T16147 1831-1838 NN denotes histone
T16148 1839-1841 NN denotes H1
T16149 1842-1846 VB denotes were
T16150 1847-1851 VB denotes used
T16151 1852-1854 TO denotes to
T16152 1855-1866 VB denotes demonstrate
T16153 1867-1872 JJ denotes equal
T16154 1873-1884 JJ denotes cytoplasmic
T16155 1885-1888 CC denotes and
T16156 1889-1896 JJ denotes nuclear
T16157 1897-1904 NN denotes loading
T16158 1905-1917 RB denotes respectively
T16159 1919-1926 NN denotes Results
T16160 1927-1930 VB denotes are
T16161 1931-1940 VB denotes presented
T16162 1941-1952 RB denotes graphically
T16163 1953-1958 IN denotes below
T16164 1959-1961 IN denotes as
T16165 1962-1970 NN denotes mean±SEM
T16166 1971-1973 IN denotes of
T16167 1974-1976 IN denotes at
T16168 1977-1982 JJ denotes least
T16169 1983-1988 CD denotes three
T16170 1989-2000 JJ denotes independent
T16171 2001-2013 NN denotes experiments.
T16172 2014-2017 SYM denotes ***
T16173 2018-2019 NN denotes p
T16174 2019-2020 SYM denotes <
T16175 2020-2025 CD denotes 0.001
T16176 2026-2034 VB denotes compared
T16177 2035-2037 TO denotes to
T16178 2038-2044 NN denotes t = 0.
T16179 2045-2046 -LRB- denotes (
T16180 2046-2047 NN denotes D
T16181 2047-2048 -RRB- denotes )
T16182 2049-2055 NN denotes RT-PCR
T16183 2056-2063 VB denotes showing
T16184 2064-2068 IN denotes that
T16185 2069-2071 NN denotes FP
T16186 2072-2080 VB denotes inhibits
T16187 2081-2085 NN denotes IL-4
T16188 2086-2089 CC denotes and
T16189 2090-2094 NN denotes IL-5
T16190 2095-2099 NN denotes mRNA
T16191 2100-2110 NN denotes expression
T16192 2111-2113 IN denotes in
T16193 2114-2135 JJ denotes CD3/CD28-costimulated
T16194 2136-2141 NN denotes cells
T16195 2143-2148 NN denotes GAPDH
T16196 2149-2152 VB denotes was
T16197 2153-2157 VB denotes used
T16198 2158-2160 IN denotes as
T16199 2161-2162 DT denotes a
T16200 2163-2170 NN denotes loading
T16201 2171-2178 NN denotes control
T16202 2180-2185 JJ denotes Lower
T16203 2186-2192 NN denotes panels
T16204 2193-2197 VB denotes show
T16205 2198-2207 JJ denotes graphical
T16206 2208-2216 NN denotes analysis
T16207 2217-2219 IN denotes of
T16208 2220-2227 NN denotes results
T16209 2228-2237 VB denotes presented
T16210 2238-2240 IN denotes as
T16211 2241-2249 NN denotes mean±SEM
T16212 2250-2252 IN denotes of
T16213 2253-2255 IN denotes at
T16214 2256-2261 JJ denotes least
T16215 2262-2267 CD denotes three
T16216 2268-2279 JJ denotes independent
T16217 2280-2292 NN denotes experiments.
T16218 2293-2294 -SHARP- denotes #
T16219 2294-2295 -SHARP- denotes #
T16220 2295-2296 -SHARP- denotes #
T16221 2018-2019 NN denotes p
T16222 2019-2020 SYM denotes <
T16223 2020-2025 CD denotes 0.001
T16224 2026-2034 VB denotes compared
T16225 2035-2037 TO denotes to
T16226 2317-2324 NN denotes control
T16227 2324-2325 -COMMA- denotes ,
T16228 2326-2330 NN denotes ***p
T16229 2330-2331 SYM denotes <
T16230 2331-2336 CD denotes 0.001
T16231 2337-2345 VB denotes compared
T16232 2346-2348 TO denotes to
T16233 2349-2374 JJ denotes anti-CD3/CD28–stimulated.
T16234 2375-2376 -LRB- denotes (
T16235 2376-2377 NN denotes E
T16236 2377-2378 -RRB- denotes )
T16237 2379-2381 NN denotes FP
T16238 2382-2383 -LRB- denotes (
T16239 2383-2385 CD denotes 10
T16240 2386-2388 NN denotes nM
T16241 2388-2389 -RRB- denotes )
T16242 2390-2397 VB denotes reduces
T16243 2398-2401 DT denotes the
T16244 2402-2409 NN denotes ability
T16245 2410-2412 IN denotes of
T16246 2413-2437 JJ denotes anti-CD3/CD28-stimulated
T16247 2438-2444 NN denotes GATA-3
T16248 2445-2447 TO denotes to
T16249 2448-2457 VB denotes associate
T16250 2458-2462 IN denotes with
T16251 2463-2466 DT denotes the
T16252 2467-2473 JJ denotes native
T16253 2474-2478 NN denotes IL-5
T16254 2479-2487 NN denotes promoter
T16255 2488-2490 CD denotes 60
T16256 2491-2494 NN denotes min
T16257 2495-2500 IN denotes after
T16258 2501-2512 NN denotes stimulation
T16259 2514-2518 NN denotes Data
T16260 2519-2522 VB denotes are
T16261 2523-2527 RB denotes also
T16262 2528-2533 VB denotes shown
T16263 2534-2545 RB denotes graphically
T16264 2546-2548 IN denotes as
T16265 2549-2557 NN denotes mean±SEM
T16266 2558-2560 IN denotes of
T16267 2561-2566 CD denotes three
T16268 2567-2578 JJ denotes independent
T16269 2579-2590 NN denotes experiments
T16270 2592-2595 DT denotes All
T16271 2596-2600 NN denotes data
T16272 2601-2605 VB denotes were
T16273 2606-2614 VB denotes analysed
T16274 2615-2617 IN denotes by
T16275 2618-2623 NN denotes ANOVA
T16276 2624-2632 VB denotes followed
T16277 2633-2635 IN denotes by
T16278 2636-2648 NN denotes Newman-Keuls
T16279 2649-2658 JJ denotes post-test
T16826 3572-3583 NN denotes Fluticasone
T16827 3584-3594 NN denotes propionate
T16828 3595-3602 VB denotes reduces
T16829 3603-3609 NN denotes GATA-3
T16830 3610-3621 NN denotes association
T16831 3622-3626 IN denotes with
T16832 3627-3637 NN denotes importin-α
T16833 3638-3641 CC denotes and
T16834 3642-3648 NN denotes GATA-3
T16835 3649-3656 JJ denotes nuclear
T16836 3657-3663 NN denotes import
T16837 3665-3666 -LRB- denotes (
T16838 3666-3667 NN denotes A
T16839 3667-3668 -RRB- denotes )
T16840 3669-3676 JJ denotes Western
T16841 3677-3681 NN denotes blot
T16842 3682-3690 NN denotes analysis
T16843 3691-3703 VB denotes demonstrates
T16844 3704-3705 DT denotes a
T16845 3706-3711 NN denotes time-
T16846 3712-3713 -LRB- denotes (
T16847 3713-3715 IN denotes at
T16848 3716-3720 CD denotes 10−8
T16849 3721-3722 NN denotes M
T16850 3723-3725 NN denotes FP
T16851 3725-3726 -RRB- denotes )
T16852 3727-3730 CC denotes and
T16853 3731-3745 NN denotes concentration-
T16854 3746-3747 -LRB- denotes (
T16855 3747-3749 IN denotes at
T16856 3750-3752 CD denotes 60
T16857 3753-3756 NN denotes min
T16858 3757-3762 IN denotes after
T16859 3763-3774 NN denotes stimulation
T16860 3774-3775 -RRB- denotes )
T16861 3776-3785 JJ denotes dependent
T16862 3786-3795 NN denotes induction
T16863 3796-3798 IN denotes of
T16864 3799-3811 JJ denotes FP-activated
T16865 3812-3814 NN denotes GR
T16866 3815-3826 NN denotes interaction
T16867 3827-3831 IN denotes with
T16868 3832-3842 NN denotes importin-α
T16869 3843-3844 -LRB- denotes (
T16870 3844-3849 NN denotes Imp-α
T16871 3849-3850 -RRB- denotes )
T16872 3852-3853 DT denotes A
T16873 3854-3862 JJ denotes positive
T16874 3863-3870 NN denotes control
T16875 3871-3874 IN denotes for
T16876 3875-3877 NN denotes GR
T16877 3878-3889 NN denotes association
T16878 3890-3894 IN denotes with
T16879 3895-3903 NN denotes importin
T16880 3904-3906 VB denotes is
T16881 3907-3912 VB denotes shown
T16882 3914-3928 NN denotes Quantification
T16883 3929-3931 IN denotes of
T16884 3932-3935 DT denotes the
T16885 3936-3948 NN denotes densitometry
T16886 3949-3953 NN denotes data
T16887 3954-3956 VB denotes is
T16888 3957-3962 VB denotes shown
T16889 3963-3968 IN denotes below
T16890 3970-3974 DT denotes Each
T16891 3975-3978 NN denotes bar
T16892 3979-3989 VB denotes represents
T16893 3990-3998 NN denotes mean±SEM
T16894 3999-4001 IN denotes of
T16895 4002-4004 IN denotes at
T16896 4005-4010 JJ denotes least
T16897 4011-4016 CD denotes three
T16898 4017-4028 JJ denotes independent
T16899 4029-4041 NN denotes experiments.
T16900 4042-4045 SYM denotes ***
T16901 4046-4047 NN denotes p
T16902 4047-4048 SYM denotes <
T16903 4048-4053 CD denotes 0.001
T16904 4054-4062 VB denotes compared
T16905 4063-4065 TO denotes to
T16906 4066-4073 NN denotes control
T16907 4073-4074 -COMMA- denotes ,
T16908 4075-4076 -SHARP- denotes #
T16909 4076-4077 -SHARP- denotes #
T16910 4077-4078 -SHARP- denotes #
T16911 4079-4080 NN denotes p
T16912 4080-4081 SYM denotes <
T16913 4081-4087 CD denotes 0.001.
T16914 4088-4089 -LRB- denotes (
T16915 4089-4090 NN denotes B
T16916 4090-4091 -RRB- denotes )
T16917 4092-4099 JJ denotes Western
T16918 4100-4104 NN denotes blot
T16919 4105-4113 NN denotes analysis
T16920 4114-4126 VB denotes demonstrated
T16921 4127-4128 DT denotes a
T16922 4129-4134 NN denotes time-
T16923 4135-4136 -LRB- denotes (
T16924 4136-4138 IN denotes at
T16925 4139-4143 CD denotes 10−8
T16926 4144-4145 NN denotes M
T16927 4146-4148 NN denotes FP
T16928 4148-4149 -RRB- denotes )
T16929 4150-4153 CC denotes and
T16930 4154-4168 NN denotes concentration-
T16931 4169-4170 -LRB- denotes (
T16932 4170-4172 IN denotes at
T16933 4173-4175 CD denotes 60
T16934 4176-4179 NN denotes min
T16935 4180-4185 IN denotes after
T16936 4186-4197 NN denotes stimulation
T16937 4197-4198 -RRB- denotes )
T16938 4199-4208 JJ denotes dependent
T16939 4209-4218 NN denotes induction
T16940 4219-4221 IN denotes of
T16941 4222-4234 JJ denotes FP-activated
T16942 4235-4237 NN denotes GR
T16943 4238-4245 JJ denotes nuclear
T16944 4246-4259 NN denotes translocation
T16945 4260-4268 VB denotes measured
T16946 4269-4271 IN denotes by
T16947 4272-4274 NN denotes IP
T16948 4276-4290 NN denotes Quantification
T16949 4291-4293 IN denotes of
T16950 4294-4297 DT denotes the
T16951 4298-4310 NN denotes densitometry
T16952 4311-4315 NN denotes data
T16953 4316-4318 VB denotes is
T16954 4319-4324 VB denotes shown
T16955 4325-4330 IN denotes below
T16956 4332-4336 DT denotes Each
T16957 4337-4340 NN denotes bar
T16958 4341-4351 VB denotes represents
T16959 4352-4360 NN denotes mean±SEM
T16960 4361-4363 IN denotes of
T16961 4364-4366 IN denotes at
T16962 4367-4372 JJ denotes least
T16963 4373-4378 CD denotes three
T16964 4379-4390 JJ denotes independent
T16965 4391-4403 NN denotes experiments.
T16966 4404-4408 NN denotes ***p
T16967 4408-4409 SYM denotes <
T16968 4409-4414 CD denotes 0.001
T16969 4415-4423 VB denotes compared
T16970 4424-4426 TO denotes to
T16971 4427-4435 NN denotes control.
T16972 4436-4437 -LRB- denotes (
T16973 4437-4438 NN denotes C
T16974 4438-4439 -RRB- denotes )
T16975 4440-4447 JJ denotes Western
T16976 4448-4452 NN denotes blot
T16977 4453-4461 NN denotes analysis
T16978 4462-4464 IN denotes of
T16979 4465-4471 NN denotes HuT-78
T16980 4472-4477 NN denotes cells
T16981 4478-4485 VB denotes treated
T16982 4486-4490 IN denotes with
T16983 4491-4493 NN denotes FP
T16984 4494-4497 CC denotes and
T16985 4498-4511 JJ denotes anti-CD3/CD28
T16986 4512-4526 NN denotes co-stimulation
T16987 4527-4539 VB denotes demonstrated
T16988 4540-4541 DT denotes a
T16989 4542-4565 JJ denotes concentration-dependent
T16990 4566-4574 NN denotes decrease
T16991 4575-4577 IN denotes in
T16992 4578-4595 NN denotes GATA-3–importin-α
T16993 4596-4607 NN denotes association
T16994 4608-4610 IN denotes at
T16995 4611-4613 CD denotes 20
T16996 4614-4617 NN denotes min
T16997 4619-4633 NN denotes Quantification
T16998 4634-4636 IN denotes of
T16999 4637-4640 DT denotes the
T17000 4641-4653 NN denotes densitometry
T17001 4654-4658 NN denotes data
T17002 4659-4661 VB denotes is
T17003 4662-4667 VB denotes shown
T17004 4668-4673 IN denotes below
T17005 4675-4679 DT denotes Each
T17006 4680-4683 NN denotes bar
T17007 4684-4694 VB denotes represents
T17008 4695-4703 NN denotes mean±SEM
T17009 4704-4706 IN denotes of
T17010 4707-4709 IN denotes at
T17011 4710-4715 JJ denotes least
T17012 4716-4721 CD denotes three
T17013 4722-4733 JJ denotes independent
T17014 4734-4746 NN denotes experiments.
T17015 4747-4748 -SHARP- denotes #
T17016 4748-4749 -SHARP- denotes #
T17017 4749-4750 -SHARP- denotes #
T17018 2018-2019 NN denotes p
T17019 2019-2020 SYM denotes <
T17020 2020-2025 CD denotes 0.001
T17021 2026-2034 VB denotes compared
T17022 2035-2037 TO denotes to
T17023 2317-2324 NN denotes control
T17024 2324-2325 -COMMA- denotes ,
T17025 2326-2330 NN denotes ***p
T17026 2330-2331 SYM denotes <
T17027 2331-2336 CD denotes 0.001
T17028 2337-2345 VB denotes compared
T17029 2346-2348 TO denotes to
T17030 4803-4823 JJ denotes αCD3/CD28-stimulated
T17031 4824-4830 NN denotes cells.
T17032 4831-4832 -LRB- denotes (
T17033 4832-4833 NN denotes D
T17034 4833-4834 -RRB- denotes )
T17035 4835-4845 JJ denotes GFP-tagged
T17036 4846-4852 NN denotes GATA-3
T17037 4853-4856 VB denotes was
T17038 4857-4870 VB denotes overexpressed
T17039 4871-4874 CC denotes and
T17040 4875-4880 NN denotes cells
T17041 4881-4891 VB denotes stimulated
T17042 4892-4893 -LRB- denotes (
T17043 4893-4894 NN denotes b
T17044 4894-4895 -COMMA- denotes ,
T17045 4896-4897 NN denotes c
T17046 4897-4898 -RRB- denotes )
T17047 4899-4901 CC denotes or
T17048 4902-4905 RB denotes not
T17049 4906-4907 -LRB- denotes (
T17050 4907-4908 DT denotes a
T17051 4908-4909 -RRB- denotes )
T17052 4910-4913 IN denotes for
T17053 4914-4916 CD denotes 30
T17054 4917-4920 NN denotes min
T17055 4921-4925 IN denotes with
T17056 4926-4939 NN denotes anti-CD3/CD28
T17057 4941-4944 DT denotes The
T17058 4945-4951 NN denotes effect
T17059 4952-4954 IN denotes of
T17060 4955-4957 CD denotes 30
T17061 4958-4961 NN denotes min
T17062 4962-4974 NN denotes pretreatment
T17063 4975-4977 IN denotes of
T17064 4978-4983 NN denotes cells
T17065 4984-4988 IN denotes with
T17066 4989-4991 NN denotes FP
T17067 4992-4993 -LRB- denotes (
T17068 4993-4997 CD denotes 10−8
T17069 4998-4999 NN denotes M
T17070 4999-5000 -COMMA- denotes ,
T17071 5001-5002 NN denotes c
T17072 5002-5003 -RRB- denotes )
T17073 5004-5006 VB denotes is
T17074 5007-5011 RB denotes also
T17075 5012-5017 VB denotes shown
T17076 5019-5022 DT denotes All
T17077 5023-5027 NN denotes data
T17078 5028-5032 VB denotes were
T17079 5033-5041 VB denotes analysed
T17080 5042-5044 IN denotes by
T17081 5045-5050 NN denotes ANOVA
T17082 5051-5059 VB denotes followed
T17083 5060-5062 IN denotes by
T17084 5063-5075 NN denotes Newman-Keuls
T17085 5076-5085 JJ denotes post-test
T17610 6240-6251 NN denotes Fluticasone
T17611 6252-6271 VB denotes propionate–mediated
T17612 6272-6282 NN denotes inhibition
T17613 6283-6285 IN denotes of
T17614 6286-6289 NN denotes p38
T17615 6290-6293 NN denotes MAP
T17616 6294-6300 NN denotes kinase
T17617 6301-6316 NN denotes phosphorylation
T17618 6317-6320 CC denotes and
T17619 6321-6331 NN denotes activation
T17620 6332-6334 VB denotes is
T17621 6335-6345 VB denotes associated
T17622 6346-6350 IN denotes with
T17623 6351-6352 DT denotes a
T17624 6353-6359 JJ denotes marked
T17625 6360-6375 NN denotes down-regulation
T17626 6376-6378 IN denotes of
T17627 6379-6385 NN denotes GATA-3
T17628 6386-6392 NN denotes serine
T17629 6393-6408 NN denotes phosphorylation
T17630 6410-6411 -LRB- denotes (
T17631 6411-6412 NN denotes A
T17632 6412-6413 -RRB- denotes )
T17633 6414-6421 JJ denotes Western
T17634 6422-6426 NN denotes blot
T17635 6427-6435 NN denotes analysis
T17636 6436-6441 VB denotes shows
T17637 6442-6446 IN denotes that
T17638 6447-6449 NN denotes FP
T17639 6450-6451 -LRB- denotes (
T17640 6451-6455 CD denotes 10−8
T17641 6456-6457 NN denotes M
T17642 6457-6458 -COMMA- denotes ,
T17643 6459-6461 CD denotes 30
T17644 6462-6465 NN denotes min
T17645 6465-6466 -RRB- denotes )
T17646 6467-6476 NN denotes treatment
T17647 6477-6484 VB denotes reduced
T17648 6485-6489 JJ denotes dual
T17649 6490-6505 NN denotes phosphorylation
T17650 6506-6507 -LRB- denotes (
T17651 6507-6520 CD denotes threonine-180
T17652 6521-6524 CC denotes and
T17653 6525-6537 NN denotes tyrosine-182
T17654 6537-6538 -RRB- denotes )
T17655 6539-6541 IN denotes of
T17656 6542-6545 NN denotes p38
T17657 6546-6550 NN denotes MAPK
T17658 6551-6553 IN denotes in
T17659 6554-6581 JJ denotes anti-CD3/CD28–co-stimulated
T17660 6582-6588 NN denotes HuT-78
T17661 6589-6595 NN denotes cells.
T17662 6596-6597 -LRB- denotes (
T17663 6597-6598 NN denotes B
T17664 6598-6599 -RRB- denotes )
T17665 6600-6604 NN denotes Time
T17666 6605-6611 NN denotes course
T17667 6612-6614 IN denotes of
T17668 6615-6618 DT denotes the
T17669 6619-6625 NN denotes effect
T17670 6626-6628 IN denotes of
T17671 6629-6631 NN denotes FP
T17672 6632-6633 -LRB- denotes (
T17673 6633-6637 CD denotes 10−8
T17674 6638-6639 NN denotes M
T17675 6639-6640 -RRB- denotes )
T17676 6641-6643 IN denotes on
T17677 6644-6659 NN denotes phosphorylation
T17678 6660-6662 IN denotes of
T17679 6663-6672 VB denotes activated
T17680 6673-6686 NN denotes transcription
T17681 6687-6693 NN denotes factor
T17682 6694-6695 CD denotes 2
T17683 6696-6697 -LRB- denotes (
T17684 6697-6702 NN denotes ATF-2
T17685 6702-6703 -RRB- denotes )
T17686 6703-6704 -COMMA- denotes ,
T17687 6705-6706 DT denotes a
T17688 6707-6714 NN denotes measure
T17689 6715-6717 IN denotes of
T17690 6718-6721 NN denotes p38
T17691 6722-6726 NN denotes MAPK
T17692 6727-6736 NN denotes activity.
T17693 6737-6738 -LRB- denotes (
T17694 6738-6739 NN denotes C
T17695 6739-6740 -RRB- denotes )
T17696 6741-6751 JJ denotes FP-induced
T17697 6752-6762 NN denotes inhibition
T17698 6763-6765 IN denotes of
T17699 6766-6769 NN denotes p38
T17700 6770-6774 NN denotes MAPK
T17701 6775-6783 NN denotes activity
T17702 6784-6786 VB denotes is
T17703 6787-6797 VB denotes associated
T17704 6798-6802 IN denotes with
T17705 6803-6806 DT denotes the
T17706 6807-6815 NN denotes decrease
T17707 6816-6818 IN denotes of
T17708 6819-6832 JJ denotes anti-CD3/CD28
T17709 6833-6855 JJ denotes co-stimulation–induced
T17710 6856-6862 NN denotes serine
T17711 6863-6878 NN denotes phosphorylation
T17712 6879-6880 -LRB- denotes (
T17713 6880-6885 NN denotes P-Ser
T17714 6885-6886 -RRB- denotes )
T17715 6887-6889 IN denotes of
T17716 6890-6896 NN denotes GATA-3
T17717 6898-6901 IN denotes For
T17718 6902-6903 -LRB- denotes (
T17719 6903-6906 NN denotes A–C
T17720 6906-6907 -RRB- denotes )
T17721 6907-6908 -COMMA- denotes ,
T17722 6909-6923 NN denotes quantification
T17723 6924-6926 IN denotes of
T17724 6927-6930 DT denotes the
T17725 6931-6943 NN denotes densitometry
T17726 6944-6948 NN denotes data
T17727 6949-6951 VB denotes is
T17728 6952-6956 RB denotes also
T17729 6957-6962 VB denotes shown
T17730 6964-6968 DT denotes Each
T17731 6969-6972 NN denotes bar
T17732 6973-6983 VB denotes represents
T17733 6984-6992 NN denotes mean±SEM
T17734 6993-6995 IN denotes of
T17735 6996-6998 IN denotes at
T17736 6999-7004 JJ denotes least
T17737 7005-7010 CD denotes three
T17738 7011-7022 JJ denotes independent
T17739 7023-7035 NN denotes experiments.
T17740 7036-7037 -SHARP- denotes #
T17741 7037-7038 -SHARP- denotes #
T17742 7038-7039 -SHARP- denotes #
T17743 2018-2019 NN denotes p
T17744 2019-2020 SYM denotes <
T17745 2020-2025 CD denotes 0.001
T17746 2026-2034 VB denotes compared
T17747 2035-2037 TO denotes to
T17748 2317-2324 NN denotes control
T17749 2324-2325 -COMMA- denotes ,
T17750 2326-2330 NN denotes ***p
T17751 2330-2331 SYM denotes <
T17752 2331-2336 CD denotes 0.001
T17753 2337-2345 VB denotes compared
T17754 2346-2348 TO denotes to
T17755 4803-4823 JJ denotes αCD3/CD28-stimulated
T17756 4824-4830 NN denotes cells.
T17757 4831-4832 -LRB- denotes (
T17758 4832-4833 NN denotes D
T17759 4833-4834 -RRB- denotes )
T17760 7124-7126 NN denotes FP
T17761 7127-7134 VB denotes induced
T17762 7135-7140 NN denotes MKP-1
T17763 7141-7145 NN denotes mRNA
T17764 7146-7148 IN denotes in
T17765 7149-7150 DT denotes a
T17766 7151-7174 JJ denotes concentration-dependent
T17767 7175-7181 NN denotes manner
T17768 7183-7186 DT denotes All
T17769 7187-7194 NN denotes results
T17770 7195-7198 VB denotes are
T17771 7199-7213 JJ denotes representative
T17772 7214-7216 IN denotes of
T17773 7217-7219 IN denotes at
T17774 7220-7225 JJ denotes least
T17775 7226-7231 CD denotes three
T17776 7232-7243 JJ denotes independent
T17777 7244-7255 NN denotes experiments
T17778 7256-7259 CC denotes and
T17779 7260-7265 WRB denotes where
T17780 7266-7277 JJ denotes appropriate
T17781 7278-7287 VB denotes expressed
T17782 7288-7290 IN denotes as
T17783 7291-7300 NN denotes means±SEM
T17784 7300-7301 -COMMA- denotes ,
T17785 7302-7304 NN denotes *p
T17786 7304-7305 SYM denotes <
T17787 7305-7310 CD denotes 0.05.
T17788 7311-7312 -LRB- denotes (
T17789 7312-7313 NN denotes E
T17790 7313-7314 -RRB- denotes )
T17791 7315-7317 NN denotes FP
T17792 7318-7325 VB denotes induces
T17793 7326-7331 NN denotes MKP-1
T17794 7332-7336 NN denotes mRNA
T17795 7337-7339 IN denotes in
T17796 7340-7341 DT denotes a
T17797 7342-7356 JJ denotes time-dependent
T17798 7357-7363 NN denotes manner
T17799 7365-7372 NN denotes Results
T17800 7373-7376 VB denotes are
T17801 7377-7391 JJ denotes representative
T17802 7392-7394 IN denotes of
T17803 7395-7398 CD denotes two
T17804 7399-7410 JJ denotes independent
T17805 7411-7422 NN denotes experiments
T17806 7424-7427 DT denotes All
T17807 7428-7432 NN denotes data
T17808 7433-7439 IN denotes except
T17809 7440-7441 -LRB- denotes (
T17810 7441-7442 NN denotes E
T17811 7442-7443 -RRB- denotes )
T17812 7444-7448 VB denotes were
T17813 7449-7457 VB denotes analysed
T17814 7458-7460 IN denotes by
T17815 7461-7466 NN denotes ANOVA
T17816 7467-7475 VB denotes followed
T17817 7476-7478 IN denotes by
T17818 7479-7491 NN denotes Newman-Keuls
T17819 7492-7501 JJ denotes post-test
T18718 10099-10110 NN denotes Fluticasone
T18719 10111-10121 NN denotes propionate
T18720 10122-10126 VB denotes does
T18721 10127-10130 RB denotes not
T18722 10131-10137 VB denotes affect
T18723 10138-10144 NN denotes GATA-3
T18724 10145-10152 JJ denotes nuclear
T18725 10153-10159 NN denotes export
T18726 10161-10162 -LRB- denotes (
T18727 10162-10163 NN denotes A
T18728 10163-10164 -RRB- denotes )
T18729 10165-10172 JJ denotes Western
T18730 10173-10177 NN denotes blot
T18731 10178-10186 NN denotes analysis
T18732 10187-10194 VB denotes showing
T18733 10195-10199 IN denotes that
T18734 10200-10203 DT denotes the
T18735 10204-10211 JJ denotes nuclear
T18736 10212-10218 NN denotes export
T18737 10219-10228 NN denotes inhibitor
T18738 10229-10239 NN denotes leptomycin
T18739 10240-10241 NN denotes B
T18740 10242-10243 -LRB- denotes (
T18741 10243-10244 CD denotes 2
T18742 10245-10247 NN denotes nM
T18743 10247-10248 -RRB- denotes )
T18744 10249-10253 VB denotes does
T18745 10254-10257 RB denotes not
T18746 10258-10264 VB denotes affect
T18747 10265-10268 DT denotes the
T18748 10269-10276 NN denotes ability
T18749 10277-10279 IN denotes of
T18750 10280-10282 NN denotes FP
T18751 10283-10284 -LRB- denotes (
T18752 10284-10288 CD denotes 10−8
T18753 10289-10290 NN denotes M
T18754 10290-10291 -RRB- denotes )
T18755 10292-10294 TO denotes to
T18756 10295-10302 VB denotes prevent
T18757 10303-10327 JJ denotes anti-CD3/CD28–stimulated
T18758 10328-10334 NN denotes GATA-3
T18759 10335-10342 JJ denotes nuclear
T18760 10343-10355 NN denotes localization
T18761 10356-10364 VB denotes measured
T18762 10365-10367 IN denotes at
T18763 10368-10370 CD denotes 60
T18764 10371-10375 NN denotes min.
T18765 10376-10380 NN denotes ***p
T18766 10380-10381 SYM denotes <
T18767 10381-10386 CD denotes 0.001
T18768 10387-10395 VB denotes compared
T18769 10396-10398 TO denotes to
T18770 10399-10411 JJ denotes unstimulated
T18771 10412-10417 NN denotes cells
T18772 10417-10418 -COMMA- denotes ,
T18773 10419-10420 -SHARP- denotes #
T18774 10420-10421 -SHARP- denotes #
T18775 10421-10422 -SHARP- denotes #
T18776 2329-2330 NN denotes p
T18777 2330-2331 SYM denotes <
T18778 2331-2336 CD denotes 0.001
T18779 2337-2345 VB denotes compared
T18780 2346-2348 TO denotes to
T18781 2349-2373 JJ denotes anti-CD3/CD28–stimulated
T18782 10468-10474 NN denotes cells.
T18783 10475-10476 -LRB- denotes (
T18784 10476-10477 NN denotes B
T18785 10477-10478 -RRB- denotes )
T18786 10479-10486 JJ denotes Western
T18787 10487-10491 NN denotes blot
T18788 10492-10500 NN denotes analysis
T18789 10501-10508 VB denotes showing
T18790 10509-10513 IN denotes that
T18791 10514-10516 NN denotes FP
T18792 10517-10518 -LRB- denotes (
T18793 10518-10522 CD denotes 10−8
T18794 10523-10524 NN denotes M
T18795 10524-10525 -RRB- denotes )
T18796 10526-10530 VB denotes does
T18797 10531-10534 RB denotes not
T18798 10535-10541 VB denotes affect
T18799 10542-10552 JJ denotes whole-cell
T18800 10553-10559 NN denotes GATA-3
T18801 10560-10571 NN denotes degradation
T18802 10572-10576 IN denotes over
T18803 10577-10579 CD denotes 17
T18804 10580-10582 NN denotes h.
T18805 10583-10584 -LRB- denotes (
T18806 10584-10585 NN denotes C
T18807 10585-10586 -RRB- denotes )
T18808 10587-10597 JJ denotes GFP-tagged
T18809 10598-10604 NN denotes GATA-3
T18810 10605-10607 VB denotes is
T18811 10608-10621 VB denotes overexpressed
T18812 10622-10625 CC denotes and
T18813 10626-10631 NN denotes cells
T18814 10632-10642 VB denotes stimulated
T18815 10643-10644 -LRB- denotes (
T18816 10644-10647 NN denotes b–j
T18817 10647-10648 -RRB- denotes )
T18818 10649-10651 CC denotes or
T18819 10652-10655 RB denotes not
T18820 10656-10657 -LRB- denotes (
T18821 10657-10658 DT denotes a
T18822 10658-10659 -RRB- denotes )
T18823 10660-10664 IN denotes with
T18824 10665-10678 NN denotes anti-CD3/CD28
T18825 10680-10683 DT denotes The
T18826 10684-10690 NN denotes effect
T18827 10691-10693 IN denotes of
T18828 10694-10702 VB denotes treating
T18829 10703-10708 NN denotes cells
T18830 10709-10713 IN denotes with
T18831 10714-10716 NN denotes FP
T18832 10717-10718 -LRB- denotes (
T18833 10718-10722 CD denotes 10−8
T18834 10723-10724 NN denotes M
T18835 10724-10725 -COMMA- denotes ,
T18836 10726-10729 NN denotes f–j
T18837 10729-10730 -RRB- denotes )
T18838 10731-10736 IN denotes after
T18839 10737-10739 CD denotes 30
T18840 10740-10743 NN denotes min
T18841 10744-10755 NN denotes stimulation
T18842 10756-10760 IN denotes with
T18843 10761-10774 NN denotes anti-CD3/CD28
T18844 10775-10777 VB denotes is
T18845 10778-10782 RB denotes also
T18846 10783-10789 NN denotes shown.
T18847 10790-10791 -LRB- denotes (
T18848 10791-10792 NN denotes D
T18849 10792-10793 -RRB- denotes )
T18850 10794-10796 NN denotes FP
T18851 10797-10798 -LRB- denotes (
T18852 10798-10802 CD denotes 10−8
T18853 10803-10804 NN denotes M
T18854 10804-10805 -RRB- denotes )
T18855 10806-10810 VB denotes does
T18856 10811-10814 RB denotes not
T18857 10815-10822 VB denotes prevent
T18858 10823-10847 JJ denotes anti-CD3/CD28–stimulated
T18859 10848-10851 NN denotes p65
T18860 10852-10859 JJ denotes nuclear
T18861 10860-10873 NN denotes translocation
T18862 10874-10876 IN denotes at
T18863 10877-10879 CD denotes 60
T18864 10880-10883 NN denotes min
T18865 10884-10889 IN denotes after
T18866 10890-10902 NN denotes stimulation.
T18867 10903-10906 NN denotes **p
T18868 10906-10907 SYM denotes <
T18869 10907-10911 CD denotes 0.01
T18870 10912-10920 VB denotes compared
T18871 10921-10923 TO denotes to
T18872 10924-10936 JJ denotes unstimulated
T18873 10937-10942 NN denotes cells
T18874 10944-10947 DT denotes All
T18875 10948-10955 NN denotes results
T18876 10956-10959 VB denotes are
T18877 10960-10974 JJ denotes representative
T18878 10975-10977 IN denotes of
T18879 10978-10980 IN denotes at
T18880 10981-10986 JJ denotes least
T18881 10987-10991 CD denotes four
T18882 10992-11003 JJ denotes independent
T18883 11004-11015 NN denotes experiments
T18884 11016-11019 CC denotes and
T18885 11020-11023 VB denotes are
T18886 11024-11029 VB denotes shown
T18887 11030-11032 IN denotes as
T18888 11033-11041 NN denotes mean±SEM
T18889 11043-11050 NN denotes Results
T18890 11051-11055 VB denotes were
T18891 11056-11064 VB denotes analysed
T18892 11065-11067 IN denotes by
T18893 11068-11073 NN denotes ANOVA
T18894 11074-11082 VB denotes followed
T18895 11083-11085 IN denotes by
T18896 11086-11098 JJ denotes Newman-Keuls
T18897 11099-11103 NN denotes test
T19291 11626-11637 NN denotes Fluticasone
T19292 11638-11648 NN denotes propionate
T19293 11649-11656 VB denotes impairs
T19294 11657-11663 NN denotes GATA-3
T19295 11664-11675 NN denotes interaction
T19296 11676-11680 IN denotes with
T19297 11681-11691 NN denotes importin-α
T19298 11692-11695 CC denotes and
T19299 11696-11702 NN denotes GATA-3
T19300 11703-11710 JJ denotes nuclear
T19301 11711-11723 NN denotes localization
T19302 11724-11726 FW denotes in
T19303 11727-11731 FW denotes vivo
T19304 11732-11735 CC denotes and
T19305 11736-11738 FW denotes ex
T19306 11739-11743 FW denotes vivo
T19307 11745-11746 -LRB- denotes (
T19308 11746-11747 NN denotes A
T19309 11748-11751 CC denotes and
T19310 11752-11753 NN denotes B
T19311 11753-11754 -RRB- denotes )
T19312 11755-11777 NN denotes Co-immunoprecipitation
T19313 11778-11786 NN denotes analysis
T19314 11787-11789 IN denotes of
T19315 11790-11795 NN denotes PBMCs
T19316 11796-11800 IN denotes from
T19317 11801-11814 JJ denotes steroid-naïve
T19318 11815-11821 NN denotes asthma
T19319 11822-11830 NN denotes patients
T19320 11831-11838 VB denotes treated
T19321 11839-11843 IN denotes with
T19322 11844-11846 NN denotes FP
T19323 11847-11849 FW denotes in
T19324 11850-11855 FW denotes vitro
T19325 11856-11868 VB denotes demonstrated
T19326 11869-11877 JJ denotes impaired
T19327 11878-11889 NN denotes interaction
T19328 11890-11897 IN denotes between
T19329 11898-11904 NN denotes GATA-3
T19330 11905-11908 CC denotes and
T19331 11909-11919 NN denotes importin-α
T19332 11920-11928 VB denotes measured
T19333 11929-11931 IN denotes at
T19334 11932-11934 CD denotes 60
T19335 11935-11938 NN denotes min
T19336 11940-11944 DT denotes Each
T19337 11945-11948 NN denotes bar
T19338 11949-11959 VB denotes represents
T19339 11960-11963 DT denotes the
T19340 11964-11972 NN denotes mean±SEM
T19341 11973-11975 IN denotes of
T19342 11976-11978 IN denotes at
T19343 11979-11984 JJ denotes least
T19344 11985-11990 CD denotes three
T19345 11991-12002 JJ denotes independent
T19346 12003-12014 NN denotes experiments
T19347 12014-12015 -COLON- denotes ;
T19348 12016-12019 SYM denotes ***
T19349 12020-12021 NN denotes p
T19350 12021-12022 SYM denotes <
T19351 12022-12027 CD denotes 0.001
T19352 12028-12036 VB denotes compared
T19353 12037-12041 IN denotes with
T19354 12042-12049 NN denotes control
T19355 12050-12052 IN denotes as
T19356 12053-12063 VB denotes determined
T19357 12064-12066 IN denotes by
T19358 12067-12085 JJ denotes ANOVA/Newman-Keuls
T19359 12086-12095 NN denotes analysis.
T19360 12096-12097 -LRB- denotes (
T19361 12097-12098 NN denotes C
T19362 12099-12102 CC denotes and
T19363 12103-12104 NN denotes D
T19364 12104-12105 -RRB- denotes )
T19365 12106-12128 NN denotes Co-immunoprecipitation
T19366 12129-12137 NN denotes analyses
T19367 12138-12140 IN denotes of
T19368 12141-12146 NN denotes PBMCs
T19369 12147-12151 IN denotes from
T19370 12152-12165 JJ denotes steroid-naïve
T19371 12166-12172 NN denotes asthma
T19372 12173-12181 NN denotes patients
T19373 12182-12189 VB denotes treated
T19374 12190-12194 IN denotes with
T19375 12195-12202 VB denotes inhaled
T19376 12203-12205 NN denotes FP
T19377 12206-12207 -LRB- denotes (
T19378 12207-12210 CD denotes 500
T19379 12211-12213 NN denotes µg
T19380 12214-12217 IN denotes via
T19381 12218-12219 DT denotes a
T19382 12220-12226 NN denotes spacer
T19383 12226-12227 -RRB- denotes )
T19384 12228-12230 FW denotes in
T19385 12231-12235 FW denotes vivo
T19386 12236-12248 VB denotes demonstrated
T19387 12249-12258 VB denotes decreased
T19388 12259-12270 NN denotes association
T19389 12271-12278 IN denotes between
T19390 12279-12285 NN denotes GATA-3
T19391 12286-12289 CC denotes and
T19392 12290-12300 NN denotes importin-α
T19393 12302-12305 DT denotes The
T19394 12306-12316 JJ denotes individual
T19395 12317-12323 NN denotes values
T19396 12324-12327 IN denotes for
T19397 12328-12332 DT denotes each
T19398 12333-12342 NN denotes treatment
T19399 12343-12346 VB denotes are
T19400 12347-12356 VB denotes presented
T19401 12357-12369 NN denotes graphically.
T19402 12370-12371 -LRB- denotes (
T19403 12371-12372 NN denotes E
T19404 12372-12373 -RRB- denotes )
T19405 12374-12388 JJ denotes Representative
T19406 12389-12396 JJ denotes Western
T19407 12397-12401 NN denotes blot
T19408 12402-12409 VB denotes showing
T19409 12410-12414 IN denotes that
T19410 12415-12425 JJ denotes importin-α
T19411 12426-12436 NN denotes expression
T19412 12437-12440 VB denotes was
T19413 12441-12451 JJ denotes unaffected
T19414 12452-12454 IN denotes by
T19415 12455-12465 NN denotes inhalation
T19416 12466-12468 IN denotes of
T19417 12469-12471 NN denotes FP
T19418 12473-12477 NN denotes Blot
T19419 12478-12480 VB denotes is
T19420 12481-12495 JJ denotes representative
T19421 12496-12498 IN denotes of
T19422 12499-12503 NN denotes gels
T19423 12504-12508 IN denotes from
T19424 12509-12514 CD denotes three
T19425 12515-12527 NN denotes participants
T19732 14813-14820 VB denotes Inhaled
T19733 14821-14832 NN denotes fluticasone
T19734 14833-14843 NN denotes propionate
T19735 14844-14851 VB denotes impairs
T19736 14852-14858 NN denotes GATA-3
T19737 14859-14866 JJ denotes nuclear
T19738 14867-14879 NN denotes localization
T19739 14880-14882 IN denotes in
T19740 14883-14888 NN denotes PBMCs
T19741 14890-14891 -LRB- denotes (
T19742 14891-14892 NN denotes A
T19743 14892-14893 -RRB- denotes )
T19744 14894-14908 JJ denotes Representative
T19745 14909-14928 NN denotes immunocytochemistry
T19746 14929-14931 IN denotes of
T19747 14932-14939 VB denotes showing
T19748 14940-14943 DT denotes the
T19749 14944-14950 NN denotes effect
T19750 14951-14953 IN denotes of
T19751 14954-14961 VB denotes inhaled
T19752 14962-14964 NN denotes FP
T19753 14965-14966 -LRB- denotes (
T19754 14966-14969 CD denotes 500
T19755 14970-14972 NN denotes µg
T19756 14972-14973 -RRB- denotes )
T19757 14974-14976 IN denotes on
T19758 14977-14979 NN denotes GR
T19759 14980-14983 CC denotes and
T19760 14984-14990 NN denotes GATA-3
T19761 14991-14998 JJ denotes nuclear
T19762 14999-15012 NN denotes localisation.
T19763 15013-15014 -LRB- denotes (
T19764 15014-15015 NN denotes B
T19765 15015-15016 -RRB- denotes )
T19766 15017-15024 JJ denotes Nuclear
T19767 15025-15031 NN denotes GATA-3
T19768 15032-15048 NN denotes immunoreactivity
T19769 15049-15051 IN denotes in
T19770 15052-15057 NN denotes PBMCs
T19771 15058-15062 IN denotes from
T19772 15063-15068 CD denotes seven
T19773 15069-15082 JJ denotes steroid-naïve
T19774 15083-15089 NN denotes asthma
T19775 15090-15098 NN denotes patients
T19776 15099-15100 CD denotes 2
T19777 15101-15102 NN denotes h
T19778 15103-15112 VB denotes following
T19779 15113-15120 VB denotes inhaled
T19780 15121-15123 NN denotes FP
T19781 15124-15133 NN denotes treatment
T19782 15134-15135 -LRB- denotes (
T19783 15135-15138 CD denotes 100
T19784 15139-15141 CC denotes or
T19785 15142-15145 CD denotes 500
T19786 15146-15148 NN denotes µg
T19787 15149-15152 IN denotes via
T19788 15153-15159 NN denotes spacer
T19789 15159-15160 -RRB- denotes )
T19790 15162-15165 DT denotes The
T19791 15166-15172 JJ denotes median
T19792 15173-15176 CC denotes and
T19793 15177-15190 JJ denotes interquartile
T19794 15191-15197 NN denotes ranges
T19795 15198-15201 IN denotes for
T19796 15202-15206 DT denotes each
T19797 15207-15216 NN denotes treatment
T19798 15217-15220 VB denotes are
T19799 15221-15230 VB denotes presented
T19800 15231-15233 IN denotes as
T19801 15234-15235 DT denotes a
T19802 15236-15252 NN denotes box-and-whiskers
T19803 15253-15257 NN denotes plot
T19804 15258-15259 -LRB- denotes (
T19805 15259-15264 NN denotes n = 7
T19806 15264-15265 -RRB- denotes )
T19807 15265-15266 -COLON- denotes ;
T19808 15267-15268 SYM denotes *
T19809 15269-15270 NN denotes p
T19810 15270-15271 SYM denotes <
T19811 15271-15275 CD denotes 0.05
T19812 15276-15284 NNP denotes Wilcoxon
T19813 15284-15286 POS denotes 's
T19814 15287-15291 NN denotes rank
T19815 15292-15296 NN denotes test
T19816 15297-15305 VB denotes compared
T19817 15306-15310 IN denotes with
T19818 15311-15319 NN denotes placebo.
T19819 15320-15321 -LRB- denotes (
T19820 15321-15322 NN denotes C
T19821 15322-15323 -RRB- denotes )
T19822 15324-15338 NN denotes Immunoblotting
T19823 15339-15347 NN denotes analyses
T19824 15348-15350 IN denotes of
T19825 15351-15356 NN denotes PBMCs
T19826 15357-15369 VB denotes demonstrated
T19827 15370-15371 DT denotes a
T19828 15372-15386 JJ denotes time-dependent
T19829 15387-15395 NN denotes decrease
T19830 15396-15398 IN denotes in
T19831 15399-15406 JJ denotes nuclear
T19832 15407-15417 NN denotes expression
T19833 15418-15420 IN denotes of
T19834 15421-15427 NN denotes GATA-3
T19835 15427-15428 -COMMA- denotes ,
T19836 15429-15432 CC denotes and
T19837 15433-15442 VB denotes increased
T19838 15443-15454 JJ denotes cytoplasmic
T19839 15455-15461 NN denotes GATA-3
T19840 15462-15472 NN denotes expression
T19841 15473-15478 IN denotes after
T19842 15479-15489 NN denotes inhalation
T19843 15490-15492 IN denotes of
T19844 15493-15496 NNP denotes FP.
T19845 15497-15498 -LRB- denotes (
T19846 15498-15499 NN denotes D
T19847 15499-15500 -RRB- denotes )
T19848 15501-15515 NN denotes Immunoblotting
T19849 15516-15524 NN denotes analyses
T19850 15525-15527 IN denotes of
T19851 15528-15533 NN denotes PBMCs
T19852 15534-15546 VB denotes demonstrated
T19853 15547-15548 DT denotes a
T19854 15549-15563 JJ denotes dose-dependent
T19855 15564-15572 NN denotes decrease
T19856 15573-15575 IN denotes in
T19857 15576-15583 JJ denotes nuclear
T19858 15584-15594 NN denotes expression
T19859 15595-15597 IN denotes of
T19860 15598-15604 NN denotes GATA-3
T19861 15604-15605 -COMMA- denotes ,
T19862 15606-15609 CC denotes and
T19863 15610-15619 VB denotes increased
T19864 15620-15631 JJ denotes cytoplasmic
T19865 15632-15638 NN denotes GATA-3
T19866 15639-15649 NN denotes expression
T19867 15650-15651 CD denotes 2
T19868 15652-15653 NN denotes h
T19869 15654-15659 IN denotes after
T19870 15660-15670 NN denotes inhalation
T19871 15671-15673 IN denotes of
T19872 15674-15676 NN denotes FP
T19873 15678-15685 NN denotes Histone
T19874 15686-15688 NN denotes H1
T19875 15689-15692 CC denotes and
T19876 15693-15698 NN denotes MEK-1
T19877 15699-15713 NN denotes immunoblotting
T19878 15714-15723 VB denotes confirmed
T19879 15724-15734 JJ denotes equivalent
T19880 15735-15740 JJ denotes total
T19881 15741-15748 NN denotes protein
T19882 15749-15756 VB denotes loading
T19883 15757-15760 IN denotes for
T19884 15761-15764 DT denotes the
T19885 15765-15772 JJ denotes nuclear
T19886 15773-15776 CC denotes and
T19887 15777-15788 JJ denotes cytoplasmic
T19888 15789-15798 NN denotes fractions
T19889 15799-15811 RB denotes respectively
T19890 15813-15827 NN denotes Quantification
T19891 15828-15830 IN denotes of
T19892 15831-15834 DT denotes the
T19893 15835-15847 NN denotes densitometry
T19894 15848-15852 NN denotes data
T19895 15853-15855 IN denotes in
T19896 15856-15857 -LRB- denotes (
T19897 15857-15858 NN denotes C
T19898 15858-15859 -RRB- denotes )
T19899 15860-15863 CC denotes and
T19900 15864-15865 -LRB- denotes (
T19901 15865-15866 NN denotes D
T19902 15866-15867 -RRB- denotes )
T19903 15868-15870 VB denotes is
T19904 15871-15876 VB denotes shown
T19905 15877-15879 IN denotes as
T19906 15880-15881 DT denotes a
T19907 15882-15898 JJ denotes box-and-whiskers
T19908 15899-15903 NN denotes plot
T19909 15904-15906 IN denotes of
T19910 15907-15914 NN denotes results
T19911 15915-15919 IN denotes from
T19912 15920-15925 NN denotes n = 6
T19913 15926-15938 NN denotes participants
T19914 15939-15942 IN denotes for
T19915 15943-15948 WDT denotes which
T19916 15949-15953 NN denotes data
T19917 15954-15958 VB denotes were
T19918 15959-15969 JJ denotes available.
T19919 15970-15972 NN denotes *p
T19920 15972-15973 SYM denotes <
T19921 15973-15977 CD denotes 0.05
T19922 15978-15986 VB denotes compared
T19923 15987-15989 TO denotes to
T19924 15990-15998 VB denotes control.
T19925 15999-16000 -LRB- denotes (
T19926 16000-16001 NN denotes E
T19927 16001-16002 -RRB- denotes )
T19928 16003-16010 JJ denotes Western
T19929 16011-16015 NN denotes blot
T19930 16016-16024 NN denotes analyses
T19931 16025-16027 IN denotes of
T19932 16028-16033 NN denotes PBMCs
T19933 16034-16046 VB denotes demonstrated
T19934 16047-16048 DT denotes a
T19935 16049-16063 JJ denotes time-dependent
T19936 16064-16072 NN denotes decrease
T19937 16073-16075 IN denotes in
T19938 16076-16080 JJ denotes dual
T19939 16081-16096 NN denotes phosphorylation
T19940 16097-16098 -LRB- denotes (
T19941 16098-16111 CD denotes threonine-180
T19942 16112-16115 CC denotes and
T19943 16116-16128 NN denotes tyrosine-182
T19944 16128-16129 -RRB- denotes )
T19945 16130-16132 IN denotes of
T19946 16133-16136 NN denotes p38
T19947 16137-16141 NN denotes MAPK
T19948 16142-16147 IN denotes after
T19949 16148-16158 NN denotes inhalation
T19950 16159-16161 IN denotes of
T19951 16162-16164 NN denotes FP
T19952 16165-16166 -LRB- denotes (
T19953 16166-16169 CD denotes 500
T19954 16170-16172 NN denotes µg
T19955 16172-16173 -RRB- denotes )
T19956 16175-16178 DT denotes The
T19957 16179-16186 NN denotes results
T19958 16187-16192 VB denotes shown
T19959 16193-16195 IN denotes in
T19960 16196-16197 -LRB- denotes (
T19961 16197-16198 NN denotes E
T19962 16198-16199 -RRB- denotes )
T19963 16200-16203 VB denotes are
T19964 16204-16218 JJ denotes representative
T19965 16219-16221 IN denotes of
T19966 16222-16229 NN denotes samples
T19967 16230-16234 IN denotes from
T19968 16235-16238 CD denotes two
T19969 16239-16251 NN denotes participants
R7117 T8246 T8245 arg1Of Effect,The
R7118 T8246 T8247 arg1Of Effect,of
R7119 T8246 T8249 arg1Of Effect,on
R7120 T8248 T8247 arg2Of Corticosteroids,of
R7121 T8252 T8250 arg1Of Translocation,GATA-3
R7122 T8252 T8251 arg1Of Translocation,Nuclear
R7123 T8252 T8253 arg1Of Translocation,and
R7124 T8253 T8249 arg2Of and,on
R7125 T8255 T8253 arg2Of mRNA,and
R7126 T8255 T8254 arg1Of mRNA,IL-4
R7127 T8256 T8257 arg1Of Corticosteroids,are
R7128 T8256 T8258 arg1Of Corticosteroids,effective
R7129 T8258 T8257 arg2Of effective,are
R7130 T8258 T8259 arg1Of effective,in
R7131 T8260 T8259 arg2Of inhibiting,in
R7132 T8260 T8270 arg1Of inhibiting,[
R7133 T8264 T8260 arg2Of expression,inhibiting
R7134 T8264 T8261 arg1Of expression,GATA-3-regulated
R7135 T8264 T8262 arg1Of expression,IL-4
R7136 T8264 T8263 arg1Of expression,gene
R7137 T8264 T8266 arg1Of expression,vitro
R7138 T8264 T8269 arg1Of expression,vivo
R7139 T8266 T8265 arg1Of vitro,in
R7140 T8266 T8267 arg1Of vitro,and
R7141 T8269 T8267 arg2Of vivo,and
R7142 T8269 T8268 arg1Of vivo,in
R7143 T8271 T8270 arg2Of 32,[
R7144 T8272 T8270 arg3Of ],[
R7145 T8273 T8275 arg1Of We,investigated
R7146 T8275 T8274 arg1Of investigated,therefore
R7147 T8277 T8278 arg1Of corticosteroids,affect
R7148 T8278 T8275 arg2Of affect,investigated
R7149 T8278 T8276 arg1Of affect,whether
R7150 T8281 T8278 arg2Of import,affect
R7151 T8281 T8279 arg1Of import,anti-CD3/CD28–stimulated
R7152 T8281 T8280 arg1Of import,nuclear
R7153 T8281 T8282 arg1Of import,of
R7154 T8283 T8282 arg2Of GATA-3,of
R7155 T8284 T8285 arg1Of Stimulation,of
R7156 T8284 T8287 arg1Of Stimulation,with
R7157 T8284 T8289 arg1Of Stimulation,resulted
R7158 T8286 T8285 arg2Of cells,of
R7159 T8288 T8287 arg2Of anti-CD3/CD28,with
R7160 T8289 T8290 arg1Of resulted,in
R7161 T8289 T8300 arg1Of resulted,","
R7162 T8289 T8301 modOf resulted,confirming
R7163 T8289 T8305 arg1Of resulted,[
R7164 T8295 T8290 arg2Of translocation,in
R7165 T8295 T8291 arg1Of translocation,a
R7166 T8295 T8292 arg1Of translocation,rapid
R7167 T8295 T8293 arg1Of translocation,cytoplasmic/nuclear
R7168 T8295 T8294 arg1Of translocation,GATA-3
R7169 T8295 T8296 arg1Of translocation,(
R7170 T8298 T8296 arg2Of 1A,(
R7171 T8298 T8297 arg1Of 1A,Figure
R7172 T8299 T8296 arg3Of ),(
R7173 T8304 T8301 arg2Of results,confirming
R7174 T8304 T8302 arg1Of results,our
R7175 T8304 T8303 arg1Of results,previous
R7176 T8306 T8305 arg2Of 12,[
R7177 T8307 T8305 arg3Of ],[
R7178 T8308 T8310 arg1Of We,confirmed
R7179 T8310 T8309 arg1Of confirmed,also
R7180 T8310 T8319 arg1Of confirmed,as
R7181 T8313 T8310 arg2Of separation,confirmed
R7182 T8313 T8311 arg1Of separation,a
R7183 T8313 T8312 arg1Of separation,clear
R7184 T8313 T8314 arg1Of separation,of
R7185 T8315 T8316 arg1Of nuclear,and
R7186 T8317 T8316 arg2Of cytosolic,and
R7187 T8318 T8314 arg2Of fractions,of
R7188 T8318 T8315 arg1Of fractions,nuclear
R7189 T8318 T8317 arg1Of fractions,cytosolic
R7190 T8320 T8319 arg2Of indicated,as
R7191 T8323 T8322 arg1Of H1,histone
R7192 T8323 T8324 arg1Of H1,and
R7193 T8324 T8320 arg1Of and,indicated
R7194 T8324 T8321 arg2Of and,by
R7195 T8326 T8324 arg2Of markers,and
R7196 T8326 T8325 arg1Of markers,MEK-1
R7197 T8326 T8327 arg1Of markers,(
R7198 T8329 T8327 arg2Of 1B,(
R7199 T8329 T8328 arg1Of 1B,Figure
R7200 T8330 T8327 arg3Of ),(
R7201 T8335 T8331 arg1Of FP,The
R7202 T8335 T8332 arg1Of FP,potent
R7203 T8335 T8333 arg1Of FP,topical
R7204 T8335 T8334 arg1Of FP,corticosteroid
R7205 T8335 T8336 arg1Of FP,caused
R7206 T8338 T8336 arg2Of loss,caused
R7207 T8338 T8337 arg1Of loss,sustained
R7208 T8338 T8339 arg1Of loss,of
R7209 T8342 T8340 arg1Of expression,nuclear
R7210 T8342 T8341 arg1Of expression,GATA-3
R7211 T8342 T8343 arg1Of expression,and
R7212 T8343 T8339 arg2Of and,of
R7213 T8343 T8348 arg1Of and,at
R7214 T8345 T8343 arg2Of retention,and
R7215 T8345 T8344 arg1Of retention,cytoplasmic
R7216 T8345 T8346 arg1Of retention,of
R7217 T8347 T8346 arg2Of GATA-3,of
R7218 T8349 T8348 arg2Of concentrations,at
R7219 T8349 T8350 arg1Of concentrations,ranging
R7220 T8350 T8351 arg1Of ranging,from
R7221 T8352 T8353 arg1Of 10−12,to
R7222 T8354 T8353 arg2Of 10−8,to
R7223 T8355 T8351 arg2Of M,from
R7224 T8355 T8352 arg1Of M,10−12
R7225 T8355 T8356 arg1Of M,","
R7226 T8355 T8357 arg1Of M,which
R7227 T8355 T8358 arg1Of M,cover
R7228 T8361 T8358 arg2Of range,cover
R7229 T8361 T8359 arg1Of range,the
R7230 T8361 T8360 arg1Of range,therapeutic
R7231 T8361 T8362 arg1Of range,[
R7232 T8363 T8362 arg2Of 37,[
R7233 T8364 T8362 arg3Of ],[
R7234 T8366 T8365 arg1Of effect,This
R7235 T8366 T8367 arg1Of effect,was
R7236 T8366 T8368 arg1Of effect,concentration-
R7237 T8366 T8370 arg1Of effect,time-dependent
R7238 T8366 T8392 arg1Of effect,was
R7239 T8366 T8393 arg2Of effect,associated
R7240 T8367 T8371 arg1Of was,","
R7241 T8367 T8372 arg1Of was,with
R7242 T8367 T8391 arg1Of was,and
R7243 T8368 T8369 arg1Of concentration-,and
R7244 T8369 T8367 arg2Of and,was
R7245 T8370 T8369 arg2Of time-dependent,and
R7246 T8375 T8372 arg2Of effect,with
R7247 T8375 T8373 arg1Of effect,a
R7248 T8375 T8374 arg1Of effect,peak
R7249 T8375 T8376 arg1Of effect,of
R7250 T8375 T8381 arg1Of effect,at
R7251 T8379 T8377 arg1Of 30,11.6-fold
R7252 T8379 T8378 arg1Of 30,at
R7253 T8380 T8376 arg2Of min,of
R7254 T8380 T8379 arg1Of min,30
R7255 T8383 T8381 arg2Of concentration,at
R7256 T8383 T8382 arg1Of concentration,a
R7257 T8383 T8384 arg1Of concentration,of
R7258 T8386 T8384 arg2Of M,of
R7259 T8386 T8385 arg1Of M,10−8
R7260 T8386 T8387 arg1Of M,(
R7261 T8389 T8387 arg2Of 1C,(
R7262 T8389 T8388 arg1Of 1C,Figure
R7263 T8390 T8387 arg3Of ),(
R7264 T8393 T8391 arg2Of associated,and
R7265 T8393 T8392 arg2Of associated,was
R7266 T8393 T8394 arg1Of associated,with
R7267 T8396 T8394 arg2Of reductions,with
R7268 T8396 T8395 arg1Of reductions,marked
R7269 T8396 T8397 arg1Of reductions,in
R7270 T8399 T8400 arg1Of IL-4,and
R7271 T8401 T8400 arg2Of IL-5,and
R7272 T8403 T8398 arg1Of expression,anti-CD3/CD28–stimulated
R7273 T8403 T8399 arg1Of expression,IL-4
R7274 T8403 T8401 arg1Of expression,IL-5
R7275 T8403 T8402 arg1Of expression,mRNA
R7276 T8403 T8404 arg1Of expression,(
R7277 T8403 T8408 arg1Of expression,and
R7278 T8406 T8404 arg2Of 1D,(
R7279 T8406 T8405 arg1Of 1D,Figure
R7280 T8407 T8404 arg3Of ),(
R7281 T8408 T8397 arg2Of and,in
R7282 T8410 T8408 arg2Of loss,and
R7283 T8410 T8409 arg1Of loss,a
R7284 T8410 T8411 arg1Of loss,of
R7285 T8410 T8414 arg1Of loss,to
R7286 T8413 T8411 arg2Of binding,of
R7287 T8413 T8412 arg1Of binding,GATA-3
R7288 T8418 T8414 arg2Of promoter,to
R7289 T8418 T8415 arg1Of promoter,the
R7290 T8418 T8416 arg1Of promoter,native
R7291 T8418 T8417 arg1Of promoter,IL-5
R7292 T8418 T8419 arg1Of promoter,(
R7293 T8421 T8419 arg2Of 1E,(
R7294 T8421 T8420 arg1Of 1E,Figure
R7295 T8422 T8419 arg3Of ),(
R7701 T8947 T8946 arg1Of GR,Ligand-Activated
R7702 T8947 T8948 arg1Of GR,Competes
R7703 T8948 T8949 arg1Of Competes,with
R7704 T8950 T8949 arg2Of GATA-3,with
R7705 T8950 T8951 arg1Of GATA-3,for
R7706 T8952 T8951 arg2Of Importin-α,for
R7707 T8953 T8954 arg1Of We,confirmed
R7708 T8953 T8956 arg1Of We,extended
R7709 T8954 T8955 arg1Of confirmed,and
R7710 T8956 T8955 arg2Of extended,and
R7711 T8958 T8954 arg2Of data,confirmed
R7712 T8958 T8956 arg2Of data,extended
R7713 T8958 T8957 arg1Of data,previous
R7714 T8958 T8959 arg1Of data,[
R7715 T8958 T8962 modOf data,to
R7716 T8958 T8963 arg1Of data,show
R7717 T8958 T8972 arg1Of data,importin-α
R7718 T8958 T8977 arg1Of data,(
R7719 T8960 T8959 arg2Of 20,[
R7720 T8961 T8959 arg3Of ],[
R7721 T8963 T8962 arg1Of show,to
R7722 T8966 T8965 arg1Of GR,ligand-activated
R7723 T8966 T8969 arg1Of GR,as
R7724 T8969 T8967 arg1Of as,as
R7725 T8969 T8968 arg1Of as,well
R7726 T8969 T8971 arg1Of as,uses
R7727 T8970 T8969 arg2Of GATA-3,as
R7728 T8971 T8963 arg2Of uses,show
R7729 T8971 T8964 arg1Of uses,that
R7730 T8972 T8973 arg1Of importin-α,for
R7731 T8976 T8973 arg2Of import,for
R7732 T8976 T8974 arg1Of import,its
R7733 T8976 T8975 arg1Of import,nuclear
R7734 T8979 T8978 arg1Of 2A,Figure
R7735 T8979 T8980 arg1Of 2A,and
R7736 T8980 T8977 arg2Of and,(
R7737 T8981 T8980 arg2Of 2B,and
R7738 T8982 T8977 arg3Of ),(
R7739 T8984 T8983 arg1Of interaction,This
R7740 T8984 T8985 arg1Of interaction,between
R7741 T8984 T8989 arg1Of interaction,was
R7742 T8984 T8990 arg1Of interaction,significant
R7743 T8984 T8999 arg1Of interaction,was
R7744 T8984 T9000 arg1Of interaction,maximal
R7745 T8986 T8987 arg1Of GR,and
R7746 T8987 T8985 arg2Of and,between
R7747 T8988 T8987 arg2Of importin-α,and
R7748 T8989 T8991 arg1Of was,at
R7749 T8989 T8998 arg1Of was,and
R7750 T8990 T8989 arg2Of significant,was
R7751 T8992 T8991 arg2Of concentrations,at
R7752 T8992 T8994 arg1Of concentrations,low
R7753 T8994 T8993 arg1Of low,as
R7754 T8994 T8995 arg1Of low,as
R7755 T8997 T8995 arg2Of M,as
R7756 T8997 T8996 arg1Of M,10−12
R7757 T8999 T8998 arg2Of was,and
R7758 T9000 T8999 arg2Of maximal,was
R7759 T9000 T9001 arg1Of maximal,with
R7760 T9002 T9003 arg1Of 10−8,M
R7761 T9004 T9001 arg2Of FP,with
R7762 T9004 T9002 arg1Of FP,10−8
R7763 T9008 T9005 arg1Of translocation,Subsequent
R7764 T9008 T9006 arg1Of translocation,GR
R7765 T9008 T9007 arg1Of translocation,nuclear
R7766 T9008 T9009 arg1Of translocation,was
R7767 T9008 T9010 arg1Of translocation,rapid
R7768 T9008 T9012 arg1Of translocation,sustained
R7769 T9009 T9013 arg1Of was,at
R7770 T9009 T9016 arg1Of was,for
R7771 T9010 T9011 arg1Of rapid,and
R7772 T9011 T9009 arg2Of and,was
R7773 T9012 T9011 arg2Of sustained,and
R7774 T9015 T9013 arg2Of levels,at
R7775 T9015 T9014 arg1Of levels,significant
R7776 T9019 T9017 arg1Of 14,at
R7777 T9019 T9018 arg1Of 14,least
R7778 T9020 T9016 arg2Of h,for
R7779 T9020 T9019 arg1Of h,14
R7780 T9020 T9021 arg1Of h,(
R7781 T9023 T9021 arg2Of 2B,(
R7782 T9023 T9022 arg1Of 2B,Figure
R7783 T9024 T9021 arg3Of ),(
R7784 T9027 T9025 arg2Of blotting,Using
R7785 T9027 T9026 arg1Of blotting,IP-Western
R7786 T9028 T9025 arg1Of we,Using
R7787 T9028 T9029 arg1Of we,showed
R7788 T9029 T9025 modOf showed,Using
R7789 T9031 T9032 arg1Of FP,at
R7790 T9031 T9035 arg1Of FP,decreased
R7791 T9034 T9032 arg2Of M,at
R7792 T9034 T9033 arg1Of M,10−12–10−8
R7793 T9035 T9029 arg2Of decreased,showed
R7794 T9035 T9030 arg1Of decreased,that
R7795 T9037 T9035 arg2Of association,decreased
R7796 T9037 T9036 arg1Of association,the
R7797 T9037 T9038 arg1Of association,between
R7798 T9039 T9040 arg1Of GATA-3,and
R7799 T9040 T9038 arg2Of and,between
R7800 T9040 T9042 arg2Of and,induced
R7801 T9041 T9040 arg2Of importin-α,and
R7802 T9045 T9042 arg1Of stimulation,induced
R7803 T9045 T9043 arg2Of stimulation,by
R7804 T9045 T9044 arg1Of stimulation,anti-CD3/CD28
R7805 T9045 T9046 arg1Of stimulation,in
R7806 T9049 T9046 arg2Of manner,in
R7807 T9049 T9047 arg1Of manner,a
R7808 T9049 T9048 arg1Of manner,concentration-dependent
R7809 T9049 T9050 arg1Of manner,(
R7810 T9052 T9050 arg2Of 2C,(
R7811 T9052 T9051 arg1Of 2C,Figure
R7812 T9053 T9050 arg3Of ),(
R7813 T9055 T9054 arg2Of addition,In
R7814 T9059 T9058 arg1Of GATA-3,GFP-labelled
R7815 T9059 T9060 arg1Of GATA-3,and
R7816 T9060 T9057 arg2Of and,using
R7817 T9062 T9060 arg2Of microscopy,and
R7818 T9062 T9061 arg1Of microscopy,confocal
R7819 T9063 T9064 arg1Of we,demonstrated
R7820 T9064 T9054 arg1Of demonstrated,In
R7821 T9064 T9056 arg1Of demonstrated,","
R7822 T9064 T9057 modOf demonstrated,using
R7823 T9068 T9066 arg1Of import,GATA-3
R7824 T9068 T9067 arg1Of import,nuclear
R7825 T9068 T9069 arg1Of import,following
R7826 T9068 T9075 arg1Of import,was
R7827 T9068 T9076 arg2Of import,attenuated
R7828 T9071 T9069 arg2Of stimulation,following
R7829 T9071 T9070 arg1Of stimulation,anti-CD3/CD28
R7830 T9071 T9072 arg1Of stimulation,for
R7831 T9074 T9072 arg2Of min,for
R7832 T9074 T9073 arg1Of min,30
R7833 T9076 T9064 arg2Of attenuated,demonstrated
R7834 T9076 T9065 arg1Of attenuated,that
R7835 T9076 T9075 arg2Of attenuated,was
R7836 T9078 T9076 arg1Of pretreatment,attenuated
R7837 T9078 T9077 arg2Of pretreatment,by
R7838 T9078 T9079 arg1Of pretreatment,with
R7839 T9080 T9079 arg2Of FP,with
R7840 T9080 T9081 arg1Of FP,(
R7841 T9080 T9085 arg1Of FP,(
R7842 T9083 T9081 arg2Of M,(
R7843 T9083 T9082 arg1Of M,10−8
R7844 T9084 T9081 arg3Of ),(
R7845 T9087 T9085 arg2Of 2D,(
R7846 T9087 T9086 arg1Of 2D,Figure
R7847 T9088 T9085 arg3Of ),(
R8309 T9702 T9703 arg1Of Effect,on
R8310 T9704 T9703 arg2Of MKP-1,on
R8311 T9705 T9706 arg1Of Dexamethasone,inhibits
R8312 T9706 T9710 arg1Of inhibits,in
R8313 T9706 T9715 arg1Of inhibits,through
R8314 T9706 T9730 arg1Of inhibits,and
R8315 T9709 T9706 arg2Of function,inhibits
R8316 T9709 T9707 arg1Of function,p38
R8317 T9709 T9708 arg1Of function,MAPK
R8318 T9714 T9710 arg2Of manner,in
R8319 T9714 T9711 arg1Of manner,a
R8320 T9714 T9712 arg1Of manner,cell
R8321 T9714 T9713 arg1Of manner,type–specific
R8322 T9718 T9715 arg2Of induction,through
R8323 T9718 T9716 arg1Of induction,the
R8324 T9718 T9717 arg1Of induction,rapid
R8325 T9718 T9719 arg1Of induction,of
R8326 T9724 T9719 arg2Of MKP-1,of
R8327 T9724 T9720 arg1Of MKP-1,the
R8328 T9724 T9721 arg1Of MKP-1,dual
R8329 T9724 T9722 arg1Of MKP-1,kinase
R8330 T9724 T9723 arg1Of MKP-1,phosphatase
R8331 T9724 T9725 arg1Of MKP-1,(
R8332 T9727 T9725 arg2Of phosphatase-1,(
R8333 T9727 T9726 arg1Of phosphatase-1,MAPK
R8334 T9728 T9725 arg3Of ),(
R8335 T9730 T9729 arg1Of and,","
R8336 T9732 T9731 arg1Of effect,this
R8337 T9732 T9733 arg1Of effect,lasts
R8338 T9733 T9730 arg2Of lasts,and
R8339 T9733 T9734 arg1Of lasts,for
R8340 T9733 T9739 arg1Of lasts,[
R8341 T9737 T9735 arg1Of 24,up
R8342 T9737 T9736 arg1Of 24,to
R8343 T9738 T9734 arg2Of h,for
R8344 T9738 T9737 arg1Of h,24
R8345 T9740 T9739 arg2Of 28,[
R8346 T9741 T9739 arg3Of ],[
R8347 T9742 T9743 arg1Of FP,(
R8348 T9745 T9743 arg2Of M,(
R8349 T9745 T9744 arg1Of M,10−8
R8350 T9746 T9743 arg3Of ),(
R8351 T9747 T9742 arg1Of treatment,FP
R8352 T9747 T9748 arg1Of treatment,of
R8353 T9747 T9757 arg1Of treatment,decreased
R8354 T9750 T9748 arg2Of cells,of
R8355 T9750 T9749 arg1Of cells,HuT-78
R8356 T9750 T9751 arg2Of cells,activated
R8357 T9751 T9755 arg1Of activated,vitro
R8358 T9753 T9751 arg1Of anti-CD3/CD28,activated
R8359 T9753 T9752 arg2Of anti-CD3/CD28,by
R8360 T9755 T9754 arg1Of vitro,in
R8361 T9757 T9756 arg1Of decreased,significantly
R8362 T9760 T9758 arg1Of phosphorylation,p38
R8363 T9760 T9759 arg1Of phosphorylation,MAPK
R8364 T9760 T9761 arg1Of phosphorylation,(
R8365 T9760 T9765 arg1Of phosphorylation,and
R8366 T9763 T9761 arg2Of 3A,(
R8367 T9763 T9762 arg1Of 3A,Figure
R8368 T9764 T9761 arg3Of ),(
R8369 T9765 T9757 arg2Of and,decreased
R8370 T9766 T9765 arg2Of activity,and
R8371 T9766 T9767 arg2Of activity,measured
R8372 T9769 T9767 arg1Of phosphorylation,measured
R8373 T9769 T9768 arg2Of phosphorylation,by
R8374 T9769 T9770 arg1Of phosphorylation,of
R8375 T9774 T9770 arg2Of ATF-2,of
R8376 T9774 T9771 arg1Of ATF-2,the
R8377 T9774 T9772 arg1Of ATF-2,downstream
R8378 T9774 T9773 arg1Of ATF-2,target
R8379 T9774 T9775 arg1Of ATF-2,(
R8380 T9777 T9775 arg2Of 3B,(
R8381 T9777 T9776 arg1Of 3B,Figure
R8382 T9778 T9775 arg3Of ),(
R8383 T9780 T9779 arg1Of effect,This
R8384 T9780 T9781 arg1Of effect,was
R8385 T9780 T9782 arg2Of effect,detected
R8386 T9780 T9787 arg2Of effect,lasted
R8387 T9782 T9783 arg1Of detected,at
R8388 T9782 T9786 arg1Of detected,and
R8389 T9785 T9783 arg2Of min,at
R8390 T9785 T9784 arg1Of min,30
R8391 T9786 T9781 arg2Of and,was
R8392 T9787 T9786 arg2Of lasted,and
R8393 T9787 T9788 arg1Of lasted,for
R8394 T9791 T9789 arg1Of 14,at
R8395 T9791 T9790 arg1Of 14,least
R8396 T9792 T9788 arg2Of h,for
R8397 T9792 T9791 arg1Of h,14
R8398 T9792 T9793 arg1Of h,(
R8399 T9795 T9793 arg2Of 3B,(
R8400 T9795 T9794 arg1Of 3B,Figure
R8401 T9796 T9793 arg3Of ),(
R8402 T9797 T9798 arg1Of FP,(
R8403 T9797 T9804 arg1Of FP,reduced
R8404 T9800 T9798 arg2Of M,(
R8405 T9800 T9799 arg1Of M,10−8
R8406 T9801 T9798 arg3Of ),(
R8407 T9804 T9802 arg1Of reduced,also
R8408 T9804 T9803 arg1Of reduced,significantly
R8409 T9807 T9804 arg2Of phosphorylation,reduced
R8410 T9807 T9805 arg1Of phosphorylation,GATA-3
R8411 T9807 T9806 arg1Of phosphorylation,serine
R8412 T9807 T9808 arg2Of phosphorylation,induced
R8413 T9811 T9808 arg1Of stimulation,induced
R8414 T9811 T9809 arg2Of stimulation,by
R8415 T9811 T9810 arg1Of stimulation,anti-CD3/CD28
R8416 T9811 T9812 arg1Of stimulation,in
R8417 T9815 T9816 arg1Of time-,and
R8418 T9817 T9816 arg2Of concentration-dependent,and
R8419 T9818 T9812 arg2Of manner,in
R8420 T9818 T9813 arg1Of manner,both
R8421 T9818 T9814 arg1Of manner,a
R8422 T9818 T9815 arg1Of manner,time-
R8423 T9818 T9817 arg1Of manner,concentration-dependent
R8424 T9818 T9819 arg1Of manner,(
R8425 T9821 T9819 arg2Of 3C,(
R8426 T9821 T9820 arg1Of 3C,Figure
R8427 T9822 T9819 arg3Of ),(
R8428 T9824 T9823 arg1Of reduction,This
R8429 T9824 T9825 arg1Of reduction,in
R8430 T9824 T9828 arg1Of reduction,was
R8431 T9824 T9830 arg2Of reduction,seen
R8432 T9827 T9825 arg2Of phosphorylation,in
R8433 T9827 T9826 arg1Of phosphorylation,GATA-3
R8434 T9830 T9828 arg2Of seen,was
R8435 T9830 T9829 arg1Of seen,also
R8436 T9830 T9831 arg1Of seen,with
R8437 T9833 T9831 arg2Of concentrations,with
R8438 T9833 T9832 arg1Of concentrations,lower
R8439 T9833 T9834 arg1Of concentrations,of
R8440 T9835 T9834 arg2Of FP,of
R8441 T9836 T9837 arg1Of We,found
R8442 T9839 T9841 arg1Of FP,induced
R8443 T9841 T9837 arg2Of induced,found
R8444 T9841 T9838 arg1Of induced,that
R8445 T9841 T9840 arg1Of induced,significantly
R8446 T9841 T9844 arg1Of induced,in
R8447 T9841 T9851 arg1Of induced,","
R8448 T9843 T9841 arg2Of mRNA,induced
R8449 T9843 T9842 arg1Of mRNA,MKP-1
R8450 T9847 T9848 arg1Of time-,and
R8451 T9849 T9848 arg2Of concentration-dependent,and
R8452 T9850 T9844 arg2Of manner,in
R8453 T9850 T9845 arg1Of manner,both
R8454 T9850 T9846 arg1Of manner,a
R8455 T9850 T9847 arg1Of manner,time-
R8456 T9850 T9849 arg1Of manner,concentration-dependent
R8457 T9852 T9841 arg3Of reaching,induced
R8458 T9852 T9855 arg1Of reaching,at
R8459 T9852 T9858 arg1Of reaching,after
R8460 T9854 T9852 arg2Of plateau,reaching
R8461 T9854 T9853 arg1Of plateau,a
R8462 T9857 T9855 arg2Of M,at
R8463 T9857 T9856 arg1Of M,10−8
R8464 T9860 T9858 arg2Of min,after
R8465 T9860 T9859 arg1Of min,10
R8466 T9860 T9861 arg1Of min,(
R8467 T9863 T9862 arg1Of 3D,Figure
R8468 T9863 T9864 arg1Of 3D,and
R8469 T9864 T9861 arg2Of and,(
R8470 T9865 T9864 arg2Of 3E,and
R8471 T9866 T9861 arg3Of ),(
R8472 T9870 T9869 arg1Of effects,the
R8473 T9870 T9871 arg1Of effects,of
R8474 T9870 T9873 arg1Of effects,on
R8475 T9870 T9884 arg1Of effects,are
R8476 T9870 T9885 arg2Of effects,seen
R8477 T9872 T9871 arg2Of FP,of
R8478 T9876 T9874 arg1Of import,GATA-3
R8479 T9876 T9875 arg1Of import,nuclear
R8480 T9876 T9877 arg1Of import,","
R8481 T9877 T9880 arg1Of ",",and
R8482 T9879 T9877 arg2Of association,","
R8483 T9879 T9878 arg1Of association,importin-α
R8484 T9880 T9873 arg2Of and,on
R8485 T9883 T9880 arg2Of expression,and
R8486 T9883 T9881 arg1Of expression,IL-4
R8487 T9883 T9882 arg1Of expression,mRNA
R8488 T9885 T9867 arg1Of seen,However
R8489 T9885 T9868 arg1Of seen,","
R8490 T9885 T9884 arg2Of seen,are
R8491 T9885 T9886 arg1Of seen,at
R8492 T9888 T9887 arg1Of lower,"10,000-fold"
R8493 T9889 T9886 arg2Of concentrations,at
R8494 T9889 T9888 arg1Of concentrations,lower
R8495 T9889 T9890 arg1Of concentrations,(
R8496 T9892 T9891 arg1Of M,10−12
R8497 T9892 T9894 arg1Of M,see
R8498 T9894 T9890 arg2Of see,(
R8499 T9894 T9893 arg1Of see,","
R8500 T9895 T9894 arg2Of Figure,see
R8501 T9895 T9896 arg1Of Figure,2
R8502 T9897 T9890 arg3Of ),(
R8503 T9898 T9908 modOf Using,utilizing
R8504 T9901 T9900 arg1Of vitro,in
R8505 T9903 T9898 arg2Of assay,Using
R8506 T9903 T9899 arg1Of assay,an
R8507 T9903 T9901 arg1Of assay,vitro
R8508 T9903 T9902 arg1Of assay,competition
R8509 T9903 T9904 arg1Of assay,(
R8510 T9906 T9904 arg2Of 4A,(
R8511 T9906 T9905 arg1Of 4A,Figure
R8512 T9907 T9904 arg3Of ),(
R8513 T9911 T9909 arg2Of GATA-3,purified
R8514 T9911 T9910 arg2Of GATA-3,activated
R8515 T9911 T9912 arg1Of GATA-3,","
R8516 T9912 T9915 arg1Of ",",and
R8517 T9913 T9912 arg2Of importin-α,","
R8518 T9915 T9908 arg2Of and,utilizing
R8519 T9915 T9914 arg1Of and,","
R8520 T9917 T9915 arg2Of GR,and
R8521 T9917 T9916 arg2Of GR,activated
R8522 T9919 T9920 arg1Of we,demonstrated
R8523 T9920 T9898 modOf demonstrated,Using
R8524 T9920 T9918 arg1Of demonstrated,","
R8525 T9923 T9922 arg2Of GR,activated
R8526 T9923 T9925 arg1Of GR,increased
R8527 T9925 T9920 arg2Of increased,demonstrated
R8528 T9925 T9921 arg1Of increased,that
R8529 T9925 T9924 arg1Of increased,significantly
R8530 T9925 T9928 arg1Of increased,in
R8531 T9927 T9925 arg2Of association,increased
R8532 T9927 T9926 arg1Of association,GR-importin-α
R8533 T9930 T9931 arg1Of presence,and
R8534 T9931 T9928 arg2Of and,in
R8535 T9931 T9929 arg1Of and,the
R8536 T9932 T9931 arg2Of absence,and
R8537 T9935 T9925 arg3Of GATA-3,increased
R8538 T9935 T9933 arg1Of GATA-3,of
R8539 T9935 T9934 arg2Of GATA-3,activated
R8540 T9935 T9936 arg1Of GATA-3,(
R8541 T9938 T9936 arg2Of 4B,(
R8542 T9938 T9937 arg1Of 4B,Figure
R8543 T9939 T9936 arg3Of ),(
R8544 T9941 T9940 arg1Of effect,This
R8545 T9941 T9942 arg1Of effect,is
R8546 T9942 T9943 arg1Of is,not
R8547 T9944 T9945 arg1Of mutual,","
R8548 T9944 T9946 arg1Of mutual,since
R8549 T9947 T9946 arg2Of activated,since
R8550 T9948 T9944 arg1Of GATA-3,mutual
R8551 T9948 T9949 arg1Of GATA-3,did
R8552 T9948 T9951 arg1Of GATA-3,block
R8553 T9951 T9942 arg2Of block,is
R8554 T9951 T9949 arg2Of block,did
R8555 T9951 T9950 arg1Of block,not
R8556 T9953 T9951 arg2Of association,block
R8557 T9953 T9952 arg1Of association,GR–importin-α
R8558 T9953 T9954 arg1Of association,(
R8559 T9956 T9954 arg2Of 4C,(
R8560 T9956 T9955 arg1Of 4C,Figure
R8561 T9957 T9954 arg3Of ),(
R8562 T9959 T9958 arg1Of data,These
R8563 T9959 T9961 arg1Of data,suggest
R8564 T9961 T9960 arg1Of suggest,also
R8565 T9965 T9966 arg1Of GR,and
R8566 T9966 T9963 arg1Of and,both
R8567 T9966 T9964 arg2Of and,activated
R8568 T9966 T9968 arg1Of and,can
R8569 T9966 T9970 arg1Of and,associate
R8570 T9967 T9966 arg2Of phospho-GATA-3,and
R8571 T9970 T9962 arg1Of associate,that
R8572 T9970 T9968 arg2Of associate,can
R8573 T9970 T9969 arg1Of associate,directly
R8574 T9970 T9971 arg1Of associate,with
R8575 T9970 T9977 arg1Of associate,and
R8576 T9972 T9971 arg2Of importin-α,with
R8577 T9972 T9973 arg1Of importin-α,(
R8578 T9975 T9973 arg2Of 4D,(
R8579 T9975 T9974 arg1Of 4D,Figure
R8580 T9976 T9973 arg3Of ),(
R8581 T9977 T9961 arg2Of and,suggest
R8582 T9978 T9977 arg2Of that,and
R8583 T9980 T9979 arg2Of GR,activated
R8584 T9980 T9981 arg1Of GR,attenuates
R8585 T9981 T9978 arg2Of attenuates,that
R8586 T9981 T9985 arg1Of attenuates,in
R8587 T9984 T9981 arg2Of interaction,attenuates
R8588 T9984 T9982 arg1Of interaction,the
R8589 T9984 T9983 arg1Of interaction,phospho-GATA-3/importin-α
R8590 T9988 T9985 arg2Of manner,in
R8591 T9988 T9986 arg1Of manner,a
R8592 T9988 T9987 arg1Of manner,concentration-dependent
R8593 T9988 T9989 arg1Of manner,(
R8594 T9991 T9989 arg2Of 4E,(
R8595 T9991 T9990 arg1Of 4E,Figure
R8596 T9992 T9989 arg3Of ),(
R8597 T9995 T9996 arg1Of this,suggests
R8598 T9996 T9993 arg1Of suggests,Together
R8599 T9996 T9994 arg1Of suggests,","
R8600 T9999 T9998 arg1Of GR,ligand-activated
R8601 T9999 T10000 arg1Of GR,may
R8602 T9999 T10001 arg1Of GR,compete
R8603 T9999 T10008 arg1Of GR,limit
R8604 T10001 T10000 arg2Of compete,may
R8605 T10001 T10002 arg1Of compete,with
R8606 T10001 T10004 arg1Of compete,for
R8607 T10001 T10006 arg1Of compete,and
R8608 T10003 T10002 arg2Of phospho-GATA-3,with
R8609 T10005 T10004 arg2Of importin-α,for
R8610 T10006 T9996 arg2Of and,suggests
R8611 T10006 T9997 arg1Of and,that
R8612 T10008 T10006 arg2Of limit,and
R8613 T10008 T10007 arg1Of limit,thereby
R8614 T10011 T10008 arg2Of import,limit
R8615 T10011 T10009 arg1Of import,GATA-3
R8616 T10011 T10010 arg1Of import,nuclear
R8617 T10014 T10012 arg1Of interpretations,Other
R8618 T10014 T10013 arg1Of interpretations,possible
R8619 T10014 T10015 arg1Of interpretations,of
R8620 T10014 T10018 arg1Of interpretations,could
R8621 T10014 T10019 arg1Of interpretations,include
R8622 T10017 T10015 arg2Of results,of
R8623 T10017 T10016 arg1Of results,our
R8624 T10019 T10018 arg2Of include,could
R8625 T10021 T10019 arg2Of effect,include
R8626 T10021 T10020 arg1Of effect,an
R8627 T10021 T10022 arg1Of effect,of
R8628 T10021 T10024 arg1Of effect,on
R8629 T10023 T10022 arg2Of FP,of
R8630 T10027 T10025 arg1Of export,GATA-3
R8631 T10027 T10026 arg1Of export,nuclear
R8632 T10027 T10028 arg1Of export,and/or
R8633 T10028 T10024 arg2Of and/or,on
R8634 T10029 T10028 arg2Of degradation,and/or
R8635 T10031 T10030 arg1Of B,Leptomycin
R8636 T10031 T10032 arg1Of B,","
R8637 T10031 T10033 arg1Of B,which
R8638 T10031 T10034 arg1Of B,inhibits
R8639 T10031 T10038 arg1Of B,did
R8640 T10031 T10040 arg1Of B,affect
R8641 T10036 T10034 arg2Of export,inhibits
R8642 T10036 T10035 arg1Of export,nuclear
R8643 T10040 T10037 arg1Of affect,","
R8644 T10040 T10038 arg2Of affect,did
R8645 T10040 T10039 arg1Of affect,not
R8646 T10042 T10040 arg2Of ability,affect
R8647 T10042 T10041 arg1Of ability,the
R8648 T10042 T10043 arg1Of ability,of
R8649 T10042 T10045 modOf ability,to
R8650 T10044 T10043 arg2Of FP,of
R8651 T10046 T10045 arg1Of block,to
R8652 T10049 T10046 arg2Of localization,block
R8653 T10049 T10047 arg1Of localization,GATA-3
R8654 T10049 T10048 arg1Of localization,nuclear
R8655 T10049 T10050 arg1Of localization,(
R8656 T10052 T10050 arg2Of 5A,(
R8657 T10052 T10051 arg1Of 5A,Figure
R8658 T10053 T10050 arg3Of ),(
R8659 T10056 T10057 arg1Of FP,had
R8660 T10057 T10054 arg1Of had,Additionally
R8661 T10057 T10055 arg1Of had,","
R8662 T10057 T10060 arg1Of had,on
R8663 T10057 T10065 arg1Of had,during
R8664 T10059 T10057 arg2Of effect,had
R8665 T10059 T10058 arg1Of effect,no
R8666 T10064 T10060 arg2Of expression,on
R8667 T10064 T10061 arg1Of expression,whole
R8668 T10064 T10062 arg1Of expression,cell
R8669 T10064 T10063 arg1Of expression,GATA-3
R8670 T10068 T10065 arg2Of course,during
R8671 T10068 T10066 arg1Of course,the
R8672 T10068 T10067 arg1Of course,time
R8673 T10068 T10069 arg1Of course,of
R8674 T10068 T10072 arg1Of course,(
R8675 T10071 T10069 arg2Of experiments,of
R8676 T10071 T10070 arg1Of experiments,these
R8677 T10074 T10072 arg2Of 5B,(
R8678 T10074 T10073 arg1Of 5B,Figure
R8679 T10075 T10072 arg3Of ),(
R8680 T10077 T10076 arg1Of did,Nor
R8681 T10077 T10094 arg1Of did,","
R8682 T10077 T10095 modOf did,suggesting
R8683 T10078 T10077 arg1Of addition,did
R8684 T10078 T10079 arg1Of addition,of
R8685 T10078 T10081 arg1Of addition,subsequent
R8686 T10078 T10086 arg2Of addition,affect
R8687 T10080 T10079 arg2Of FP,of
R8688 T10081 T10082 arg1Of subsequent,to
R8689 T10085 T10082 arg2Of translocation,to
R8690 T10085 T10083 arg1Of translocation,anti-CD3/CD28
R8691 T10085 T10084 arg1Of translocation,nuclear
R8692 T10089 T10086 arg1Of residency,affect
R8693 T10089 T10087 arg1Of residency,GATA-3
R8694 T10089 T10088 arg1Of residency,nuclear
R8695 T10089 T10090 arg1Of residency,(
R8696 T10092 T10090 arg2Of 5C,(
R8697 T10092 T10091 arg1Of 5C,Figure
R8698 T10093 T10090 arg3Of ),(
R8699 T10098 T10097 arg2Of GR,activated
R8700 T10098 T10099 arg1Of GR,does
R8701 T10098 T10101 arg1Of GR,enhance
R8702 T10101 T10095 arg2Of enhance,suggesting
R8703 T10101 T10096 arg1Of enhance,that
R8704 T10101 T10099 arg2Of enhance,does
R8705 T10101 T10100 arg1Of enhance,not
R8706 T10104 T10101 arg2Of export,enhance
R8707 T10104 T10102 arg1Of export,GATA-3
R8708 T10104 T10103 arg1Of export,nuclear
R8709 T10108 T10107 arg1Of effect,the
R8710 T10108 T10109 arg1Of effect,of
R8711 T10108 T10111 arg1Of effect,on
R8712 T10108 T10115 arg1Of effect,was
R8713 T10108 T10117 arg1Of effect,nonspecific
R8714 T10110 T10109 arg2Of FP,of
R8715 T10114 T10111 arg2Of import,on
R8716 T10114 T10112 arg1Of import,GATA-3
R8717 T10114 T10113 arg1Of import,nuclear
R8718 T10115 T10105 arg1Of was,Finally
R8719 T10115 T10106 arg1Of was,","
R8720 T10115 T10116 arg1Of was,not
R8721 T10115 T10118 arg1Of was,","
R8722 T10117 T10115 arg2Of nonspecific,was
R8723 T10119 T10115 arg3Of since,was
R8724 T10120 T10121 arg1Of FP,(
R8725 T10120 T10125 arg1Of FP,had
R8726 T10123 T10121 arg2Of M,(
R8727 T10123 T10122 arg1Of M,10−8
R8728 T10124 T10121 arg3Of ),(
R8729 T10125 T10119 arg2Of had,since
R8730 T10125 T10128 arg1Of had,on
R8731 T10127 T10125 arg2Of effect,had
R8732 T10127 T10126 arg1Of effect,no
R8733 T10131 T10128 arg2Of translocation,on
R8734 T10131 T10129 arg1Of translocation,p65
R8735 T10131 T10130 arg1Of translocation,nuclear
R8736 T10131 T10132 arg2Of translocation,measured
R8737 T10132 T10133 arg1Of measured,at
R8738 T10135 T10133 arg2Of min,at
R8739 T10135 T10134 arg1Of min,60
R8740 T10135 T10136 arg1Of min,(
R8741 T10138 T10136 arg2Of 5D,(
R8742 T10138 T10137 arg1Of 5D,Figure
R8743 T10139 T10136 arg3Of ),(
R9645 T11311 T11309 arg1Of Effect,The
R9646 T11311 T11310 arg1Of Effect,Inhibitory
R9647 T11311 T11312 arg1Of Effect,of
R9648 T11311 T11314 arg1Of Effect,on
R9649 T11313 T11312 arg2Of Corticosteroids,of
R9650 T11317 T11314 arg2Of Localization,on
R9651 T11317 T11315 arg1Of Localization,GATA-3
R9652 T11317 T11316 arg1Of Localization,Nuclear
R9653 T11317 T11318 arg1Of Localization,in
R9654 T11317 T11325 arg1Of Localization,In
R9655 T11317 T11326 arg1Of Localization,Vivo
R9656 T11323 T11318 arg2Of Vivo,in
R9657 T11323 T11319 arg1Of Vivo,Primary
R9658 T11323 T11320 arg1Of Vivo,T
R9659 T11323 T11321 arg1Of Vivo,Lymphocytes
R9660 T11323 T11322 arg1Of Vivo,Ex
R9661 T11323 T11324 arg1Of Vivo,and
R9662 T11327 T11328 arg1Of Treatment,with
R9663 T11327 T11332 arg1Of Treatment,demonstrated
R9664 T11329 T11328 arg2Of FP,with
R9665 T11329 T11331 arg1Of FP,vivo
R9666 T11331 T11330 arg1Of vivo,ex
R9667 T11335 T11332 arg2Of decrease,demonstrated
R9668 T11335 T11333 arg1Of decrease,a
R9669 T11335 T11334 arg1Of decrease,concentration-dependent
R9670 T11335 T11336 arg1Of decrease,in
R9671 T11339 T11336 arg2Of interaction,in
R9672 T11339 T11337 arg1Of interaction,the
R9673 T11339 T11338 arg1Of interaction,direct
R9674 T11339 T11340 arg1Of interaction,between
R9675 T11341 T11342 arg1Of phospho-GATA-3,and
R9676 T11342 T11340 arg2Of and,between
R9677 T11342 T11344 arg1Of and,in
R9678 T11342 T11356 arg1Of and,","
R9679 T11342 T11357 arg1Of and,which
R9680 T11342 T11358 arg1Of and,was
R9681 T11342 T11360 arg2Of and,inhibited
R9682 T11342 T11377 arg2Of and,attenuated
R9683 T11343 T11342 arg2Of importin-α,and
R9684 T11345 T11344 arg2Of PBMCs,in
R9685 T11345 T11346 arg1Of PBMCs,from
R9686 T11347 T11346 arg2Of patients,from
R9687 T11347 T11348 arg1Of patients,with
R9688 T11347 T11350 arg1Of patients,(
R9689 T11349 T11348 arg2Of asthma,with
R9690 T11352 T11351 arg1Of 6A,Figure
R9691 T11352 T11353 arg1Of 6A,and
R9692 T11353 T11350 arg2Of and,(
R9693 T11354 T11353 arg2Of 6B,and
R9694 T11355 T11350 arg3Of ),(
R9695 T11360 T11361 arg1Of inhibited,at
R9696 T11360 T11375 arg1Of inhibited,and
R9697 T11362 T11363 arg1Of 10−12,M
R9698 T11364 T11361 arg2Of FP,at
R9699 T11364 T11362 arg1Of FP,10−12
R9700 T11364 T11365 arg1Of FP,(
R9701 T11366 T11365 arg2Of p,(
R9702 T11366 T11367 arg1Of p,<
R9703 T11366 T11369 arg1Of p,","
R9704 T11367 T11368 arg1Of <,0.001
R9705 T11370 T11371 arg1Of ANOVA,and
R9706 T11371 T11369 arg2Of and,","
R9707 T11373 T11371 arg2Of test,and
R9708 T11373 T11372 arg1Of test,Newman-Keuls
R9709 T11374 T11365 arg3Of ),(
R9710 T11375 T11358 arg2Of and,was
R9711 T11375 T11359 arg1Of and,significantly
R9712 T11377 T11375 arg2Of attenuated,and
R9713 T11377 T11376 arg1Of attenuated,completely
R9714 T11379 T11380 arg1Of 10−8,M
R9715 T11381 T11377 arg1Of FP,attenuated
R9716 T11381 T11378 arg2Of FP,by
R9717 T11381 T11379 arg1Of FP,10−8
R9718 T11381 T11382 arg1Of FP,(
R9719 T11383 T11382 arg2Of p,(
R9720 T11383 T11384 arg1Of p,<
R9721 T11383 T11386 arg1Of p,","
R9722 T11384 T11385 arg1Of <,0.001
R9723 T11387 T11388 arg1Of ANOVA,and
R9724 T11388 T11386 arg2Of and,","
R9725 T11390 T11388 arg2Of test,and
R9726 T11390 T11389 arg1Of test,Newman-Keuls
R9727 T11391 T11382 arg3Of ),(
R9728 T11397 T11392 arg1Of studies,Our
R9729 T11397 T11393 arg1Of studies,previous
R9730 T11397 T11394 arg1Of studies,T
R9731 T11397 T11395 arg1Of studies,cell
R9732 T11397 T11396 arg1Of studies,line
R9733 T11397 T11398 arg1Of studies,indicated
R9734 T11400 T11401 arg1Of 10−12,M
R9735 T11402 T11400 arg1Of FP,10−12
R9736 T11402 T11403 arg1Of FP,suppresses
R9737 T11402 T11410 arg1Of FP,attenuated
R9738 T11403 T11409 arg1Of suppresses,and
R9739 T11404 T11405 arg1Of IL-4,and
R9740 T11406 T11405 arg2Of -5,and
R9741 T11408 T11403 arg2Of expression,suppresses
R9742 T11408 T11404 arg1Of expression,IL-4
R9743 T11408 T11406 arg1Of expression,-5
R9744 T11408 T11407 arg1Of expression,gene
R9745 T11409 T11398 arg2Of and,indicated
R9746 T11409 T11399 arg1Of and,that
R9747 T11410 T11409 arg2Of attenuated,and
R9748 T11410 T11417 arg1Of attenuated,(
R9749 T11412 T11410 arg2Of interaction,attenuated
R9750 T11412 T11411 arg1Of interaction,the
R9751 T11412 T11413 arg1Of interaction,of
R9752 T11412 T11415 arg1Of interaction,with
R9753 T11414 T11413 arg2Of GATA-3,of
R9754 T11416 T11415 arg2Of importin-α,with
R9755 T11418 T11417 arg2Of see,(
R9756 T11420 T11421 arg1Of 1D,and
R9757 T11421 T11418 arg2Of and,see
R9758 T11421 T11419 arg1Of and,Figures
R9759 T11422 T11421 arg2Of 2,and
R9760 T11423 T11417 arg3Of ),(
R9761 T11425 T11424 arg1Of concentration,This
R9762 T11425 T11426 arg1Of concentration,is
R9763 T11425 T11427 arg1Of concentration,close
R9764 T11427 T11426 arg2Of close,is
R9765 T11427 T11428 arg1Of close,to
R9766 T11431 T11428 arg2Of levels,to
R9767 T11431 T11429 arg1Of levels,peak
R9768 T11431 T11430 arg1Of levels,plasma
R9769 T11431 T11432 arg2Of levels,obtained
R9770 T11432 T11433 arg1Of obtained,from
R9771 T11435 T11433 arg2Of patients,from
R9772 T11435 T11434 arg1Of patients,asthmatic
R9773 T11435 T11436 arg2Of patients,treated
R9774 T11436 T11437 arg1Of treated,with
R9775 T11436 T11444 arg1Of treated,[
R9776 T11439 T11437 arg2Of FP,with
R9777 T11439 T11438 arg2Of FP,inhaled
R9778 T11439 T11440 arg1Of FP,(
R9779 T11442 T11440 arg2Of µg,(
R9780 T11442 T11441 arg1Of µg,500
R9781 T11443 T11440 arg3Of ),(
R9782 T11445 T11444 arg2Of 27,[
R9783 T11446 T11444 arg3Of ],[
R9784 T11448 T11447 arg2Of FP,Inhaled
R9785 T11448 T11449 arg1Of FP,(
R9786 T11451 T11449 arg2Of µg,(
R9787 T11451 T11450 arg1Of µg,500
R9788 T11452 T11449 arg3Of ),(
R9789 T11453 T11448 arg1Of treatment,FP
R9790 T11453 T11454 arg1Of treatment,of
R9791 T11453 T11460 arg1Of treatment,reduced
R9792 T11458 T11454 arg2Of patients,of
R9793 T11458 T11455 arg1Of patients,seven
R9794 T11458 T11456 arg1Of patients,steroid-naive
R9795 T11458 T11457 arg1Of patients,asthma
R9796 T11460 T11459 arg1Of reduced,significantly
R9797 T11460 T11464 arg1Of reduced,vivo
R9798 T11460 T11465 arg1Of reduced,in
R9799 T11462 T11460 arg2Of interaction,reduced
R9800 T11462 T11461 arg1Of interaction,GATA-3–importin-α
R9801 T11464 T11463 arg1Of vivo,in
R9802 T11468 T11465 arg2Of manner,in
R9803 T11468 T11466 arg1Of manner,a
R9804 T11468 T11467 arg1Of manner,time-dependent
R9805 T11469 T11470 arg1Of This,produced
R9806 T11473 T11472 arg1Of 90,>
R9807 T11473 T11474 arg1Of 90,%
R9808 T11475 T11470 arg2Of decrease,produced
R9809 T11475 T11471 arg1Of decrease,a
R9810 T11475 T11473 arg1Of decrease,90
R9811 T11475 T11476 arg1Of decrease,in
R9812 T11475 T11479 arg1Of decrease,at
R9813 T11475 T11482 arg1Of decrease,(
R9814 T11478 T11476 arg2Of association,in
R9815 T11478 T11477 arg1Of association,GATA-3–importin-α
R9816 T11481 T11479 arg2Of h,at
R9817 T11481 T11480 arg1Of h,2
R9818 T11483 T11484 arg1Of median,[
R9819 T11483 T11489 arg1Of median,","
R9820 T11485 T11486 arg1Of 95,%
R9821 T11487 T11484 arg2Of CI,[
R9822 T11487 T11485 arg1Of CI,95
R9823 T11488 T11484 arg3Of ],[
R9824 T11489 T11482 arg2Of ",",(
R9825 T11489 T11494 arg1Of ",",versus
R9826 T11490 T11489 arg2Of "13,494",","
R9827 T11490 T11491 arg1Of "13,494",[
R9828 T11492 T11491 arg2Of "6,828–17,829",[
R9829 T11493 T11491 arg3Of ],[
R9830 T11495 T11496 arg1Of 879,[
R9831 T11495 T11499 arg1Of 879,;
R9832 T11495 T11504 arg2Of 879,'s
R9833 T11497 T11496 arg2Of "597–1,165",[
R9834 T11498 T11496 arg3Of ],[
R9835 T11500 T11499 arg2Of p,;
R9836 T11500 T11503 arg1Of p,Friedman
R9837 T11503 T11501 arg1Of Friedman,<
R9838 T11503 T11502 arg1Of Friedman,0.05
R9839 T11505 T11494 arg2Of analysis,versus
R9840 T11505 T11504 arg1Of analysis,'s
R9841 T11506 T11482 arg3Of ),(
R9842 T11509 T11510 arg1Of this,did
R9843 T11509 T11512 arg1Of this,reach
R9844 T11509 T11514 arg1Of this,using
R9845 T11512 T11507 arg1Of reach,However
R9846 T11512 T11508 arg1Of reach,","
R9847 T11512 T11510 arg2Of reach,did
R9848 T11512 T11511 arg1Of reach,not
R9849 T11512 T11514 modOf reach,using
R9850 T11512 T11522 arg1Of reach,probably
R9851 T11512 T11524 arg1Of reach,to
R9852 T11513 T11512 arg2Of significance,reach
R9853 T11515 T11516 arg2Of Wilcoxon,'s
R9854 T11518 T11514 arg2Of analysis,using
R9855 T11518 T11516 arg1Of analysis,'s
R9856 T11518 T11517 arg1Of analysis,post-test
R9857 T11518 T11519 arg1Of analysis,(
R9858 T11520 T11519 arg2Of W = 6.00,(
R9859 T11521 T11519 arg3Of ),(
R9860 T11524 T11523 arg1Of to,due
R9861 T11526 T11524 arg2Of numbers,to
R9862 T11526 T11525 arg1Of numbers,low
R9863 T11526 T11527 arg1Of numbers,of
R9864 T11528 T11527 arg2Of participants,of
R9865 T11530 T11529 arg1Of results,Similar
R9866 T11530 T11531 arg1Of results,were
R9867 T11530 T11532 arg2Of results,observed
R9868 T11532 T11531 arg2Of observed,were
R9869 T11532 T11533 arg1Of observed,when
R9870 T11535 T11534 arg1Of association,GATA-3–importin-α
R9871 T11535 T11536 arg1Of association,was
R9872 T11535 T11537 arg2Of association,measured
R9873 T11537 T11533 arg2Of measured,when
R9874 T11537 T11536 arg2Of measured,was
R9875 T11537 T11538 arg1Of measured,(
R9876 T11540 T11539 arg1Of 6C,Figure
R9877 T11540 T11541 arg1Of 6C,and
R9878 T11541 T11538 arg2Of and,(
R9879 T11542 T11541 arg2Of 6D,and
R9880 T11543 T11538 arg3Of ),(
R9881 T11546 T11544 arg1Of dose,The
R9882 T11546 T11545 arg1Of dose,lower
R9883 T11546 T11547 arg1Of dose,of
R9884 T11546 T11553 arg1Of dose,was
R9885 T11546 T11555 arg1Of dose,effective
R9886 T11548 T11547 arg2Of FP,of
R9887 T11548 T11549 arg1Of FP,(
R9888 T11551 T11549 arg2Of µg,(
R9889 T11551 T11550 arg1Of µg,100
R9890 T11552 T11549 arg3Of ),(
R9891 T11553 T11554 arg1Of was,not
R9892 T11555 T11553 arg2Of effective,was
R9893 T11558 T11556 arg1Of interaction,The
R9894 T11558 T11557 arg1Of interaction,attenuated
R9895 T11558 T11559 arg1Of interaction,of
R9896 T11558 T11561 arg1Of interaction,did
R9897 T11558 T11563 arg1Of interaction,result
R9898 T11560 T11559 arg2Of GATA-3,of
R9899 T11563 T11561 arg2Of result,did
R9900 T11563 T11562 arg1Of result,not
R9901 T11563 T11564 arg1Of result,from
R9902 T11563 T11570 arg1Of result,","
R9903 T11563 T11571 arg1Of result,as
R9904 T11567 T11564 arg2Of recycling,from
R9905 T11567 T11565 arg1Of recycling,the
R9906 T11567 T11566 arg1Of recycling,defective
R9907 T11567 T11568 arg1Of recycling,of
R9908 T11569 T11568 arg2Of importin-α,of
R9909 T11574 T11572 arg1Of decrease,a
R9910 T11574 T11573 arg1Of decrease,significant
R9911 T11574 T11575 arg1Of decrease,in
R9912 T11574 T11584 arg1Of decrease,was
R9913 T11574 T11586 arg2Of decrease,detected
R9914 T11577 T11575 arg2Of abundance,in
R9915 T11577 T11576 arg1Of abundance,the
R9916 T11577 T11578 arg1Of abundance,of
R9917 T11577 T11580 arg1Of abundance,in
R9918 T11579 T11578 arg2Of importin-α,of
R9919 T11583 T11580 arg2Of pool,in
R9920 T11583 T11581 arg1Of pool,the
R9921 T11583 T11582 arg1Of pool,cytoplasmic
R9922 T11586 T11571 arg2Of detected,as
R9923 T11586 T11584 arg2Of detected,was
R9924 T11586 T11585 arg1Of detected,not
R9925 T11586 T11587 arg1Of detected,(
R9926 T11589 T11587 arg2Of 6E,(
R9927 T11589 T11588 arg1Of 6E,Figure
R9928 T11590 T11587 arg3Of ),(
R9929 T11591 T11593 arg1Of We,examined
R9930 T11593 T11592 arg1Of examined,further
R9931 T11596 T11595 arg2Of FP,inhaled
R9932 T11596 T11597 arg1Of FP,could
R9933 T11596 T11598 arg1Of FP,affect
R9934 T11598 T11593 arg2Of affect,examined
R9935 T11598 T11594 arg1Of affect,whether
R9936 T11598 T11597 arg2Of affect,could
R9937 T11600 T11598 arg2Of localization,affect
R9938 T11600 T11599 arg1Of localization,cellular
R9939 T11600 T11601 arg1Of localization,of
R9940 T11600 T11603 arg1Of localization,in
R9941 T11602 T11601 arg2Of GATA-3,of
R9942 T11607 T11603 arg2Of cells,in
R9943 T11607 T11604 arg1Of cells,peripheral
R9944 T11607 T11605 arg1Of cells,blood
R9945 T11607 T11606 arg1Of cells,T
R9946 T11608 T11609 arg1Of Treatment,with
R9947 T11608 T11616 arg1Of Treatment,for
R9948 T11608 T11620 arg1Of Treatment,increased
R9949 T11608 T11630 arg1Of Treatment,decreased
R9950 T11611 T11609 arg2Of FP,with
R9951 T11611 T11610 arg2Of FP,inhaled
R9952 T11611 T11612 arg1Of FP,(
R9953 T11614 T11612 arg2Of µg,(
R9954 T11614 T11613 arg1Of µg,500
R9955 T11615 T11612 arg3Of ),(
R9956 T11618 T11616 arg2Of h,for
R9957 T11618 T11617 arg1Of h,2
R9958 T11620 T11628 arg1Of increased,and
R9959 T11623 T11620 arg2Of translocation,increased
R9960 T11623 T11621 arg1Of translocation,GR
R9961 T11623 T11622 arg1Of translocation,nuclear
R9962 T11623 T11624 arg1Of translocation,(
R9963 T11626 T11624 arg2Of 7A,(
R9964 T11626 T11625 arg1Of 7A,Figure
R9965 T11627 T11624 arg3Of ),(
R9966 T11628 T11619 arg1Of and,significantly
R9967 T11630 T11628 arg2Of decreased,and
R9968 T11630 T11629 arg1Of decreased,concomitantly
R9969 T11630 T11661 arg1Of decreased,compared
R9970 T11632 T11630 arg2Of number,decreased
R9971 T11632 T11631 arg1Of number,the
R9972 T11632 T11633 arg1Of number,of
R9973 T11640 T11633 arg2Of cells,of
R9974 T11640 T11634 arg1Of cells,nuclear
R9975 T11640 T11635 arg1Of cells,GATA-3
R9976 T11640 T11636 arg1Of cells,immunoreactive
R9977 T11640 T11637 arg1Of cells,peripheral
R9978 T11640 T11638 arg1Of cells,blood
R9979 T11640 T11639 arg1Of cells,T
R9980 T11640 T11641 arg1Of cells,(
R9981 T11645 T11641 arg2Of %,(
R9982 T11645 T11642 arg1Of %,37
R9983 T11645 T11643 arg1Of %,%
R9984 T11645 T11644 arg1Of %,±4.2
R9985 T11645 T11646 arg1Of %,versus
R9986 T11645 T11651 arg1Of %,","
R9987 T11650 T11646 arg2Of %,versus
R9988 T11650 T11647 arg1Of %,58.2
R9989 T11650 T11648 arg1Of %,%
R9990 T11650 T11649 arg1Of %,±4.95
R9991 T11652 T11651 arg2Of p = 0.016,","
R9992 T11652 T11653 arg1Of p = 0.016,","
R9993 T11652 T11655 arg1Of p = 0.016,","
R9994 T11654 T11653 arg2Of W = 28.0,","
R9995 T11656 T11657 arg2Of Wilcoxon,'s
R9996 T11659 T11655 arg2Of test,","
R9997 T11659 T11657 arg1Of test,'s
R9998 T11659 T11658 arg1Of test,rank
R9999 T11660 T11641 arg3Of ),(
R10000 T11662 T11661 arg2Of with,compared
R10001 T11663 T11662 arg2Of placebo,with
R10002 T11663 T11664 arg1Of placebo,as
R10003 T11665 T11664 arg2Of measured,as
R10004 T11665 T11666 arg1Of measured,by
R10005 T11667 T11666 arg2Of immunocytochemistry,by
R10006 T11667 T11668 arg1Of immunocytochemistry,(
R10007 T11670 T11669 arg1Of 7A,Figure
R10008 T11670 T11671 arg1Of 7A,and
R10009 T11671 T11668 arg2Of and,(
R10010 T11672 T11671 arg2Of 7B,and
R10011 T11673 T11668 arg3Of ),(
R10012 T11674 T11675 arg1Of This,was
R10013 T11674 T11676 arg2Of This,confirmed
R10014 T11676 T11675 arg2Of confirmed,was
R10015 T11679 T11676 arg1Of blotting,confirmed
R10016 T11679 T11677 arg2Of blotting,by
R10017 T11679 T11678 arg1Of blotting,Western
R10018 T11679 T11680 arg1Of blotting,","
R10019 T11679 T11681 arg1Of blotting,which
R10020 T11679 T11683 arg1Of blotting,indicated
R10021 T11683 T11682 arg1Of indicated,also
R10022 T11686 T11685 arg1Of effect,this
R10023 T11686 T11687 arg1Of effect,was
R10024 T11687 T11683 arg2Of was,indicated
R10025 T11687 T11684 arg1Of was,that
R10026 T11689 T11690 arg1Of time-,and
R10027 T11690 T11688 arg1Of and,both
R10028 T11691 T11690 arg2Of dose-dependent,and
R10029 T11694 T11693 arg1Of 7C,Figure
R10030 T11694 T11695 arg1Of 7C,and
R10031 T11695 T11687 arg2Of and,was
R10032 T11695 T11689 arg1Of and,time-
R10033 T11695 T11691 arg1Of and,dose-dependent
R10034 T11695 T11692 arg2Of and,(
R10035 T11696 T11695 arg2Of 7D,and
R10036 T11697 T11692 arg3Of ),(
R10037 T11701 T11700 arg2Of FP,inhaled
R10038 T11701 T11702 arg1Of FP,(
R10039 T11701 T11706 arg1Of FP,induced
R10040 T11704 T11702 arg2Of µg,(
R10041 T11704 T11703 arg1Of µg,500
R10042 T11705 T11702 arg3Of ),(
R10043 T11706 T11748 arg1Of induced,and
R10044 T11708 T11706 arg2Of loss,induced
R10045 T11708 T11707 arg1Of loss,significant
R10046 T11708 T11709 arg1Of loss,in
R10047 T11708 T11712 arg1Of loss,at
R10048 T11708 T11715 arg1Of loss,(
R10049 T11708 T11744 arg1Of loss,(
R10050 T11711 T11709 arg2Of GATA-3,in
R10051 T11711 T11710 arg1Of GATA-3,nuclear
R10052 T11714 T11712 arg2Of h,at
R10053 T11714 T11713 arg1Of h,2
R10054 T11716 T11715 arg2Of median,(
R10055 T11716 T11717 arg1Of median,[
R10056 T11716 T11722 arg1Of median,","
R10057 T11716 T11732 arg1Of median,","
R10058 T11718 T11719 arg1Of 95,%
R10059 T11720 T11717 arg2Of CI,[
R10060 T11720 T11718 arg1Of CI,95
R10061 T11721 T11717 arg3Of ],[
R10062 T11723 T11722 arg2Of 0.40,","
R10063 T11723 T11724 arg1Of 0.40,[
R10064 T11723 T11727 arg1Of 0.40,versus
R10065 T11725 T11724 arg2Of 0.27–0.53,[
R10066 T11726 T11724 arg3Of ],[
R10067 T11728 T11727 arg2Of 0.14,versus
R10068 T11728 T11729 arg1Of 0.14,[
R10069 T11730 T11729 arg2Of 0.11–0.19,[
R10070 T11731 T11729 arg3Of ],[
R10071 T11733 T11732 arg2Of p,","
R10072 T11733 T11734 arg1Of p,<
R10073 T11733 T11735 arg1Of p,0.05
R10074 T11733 T11736 arg1Of p,","
R10075 T11733 T11738 arg1Of p,","
R10076 T11737 T11736 arg2Of W = 21.00,","
R10077 T11739 T11740 arg2Of Wilcoxon,'s
R10078 T11742 T11738 arg2Of test,","
R10079 T11742 T11740 arg1Of test,'s
R10080 T11742 T11741 arg1Of test,rank
R10081 T11743 T11715 arg3Of ),(
R10082 T11746 T11744 arg2Of 7C,(
R10083 T11746 T11745 arg1Of 7C,Figure
R10084 T11747 T11744 arg3Of ),(
R10085 T11748 T11698 arg1Of and,Thus
R10086 T11748 T11699 arg1Of and,","
R10087 T11751 T11749 arg1Of levels,cytoplasmic
R10088 T11751 T11750 arg1Of levels,GATA-3
R10089 T11751 T11752 arg1Of levels,were
R10090 T11751 T11753 arg2Of levels,enhanced
R10091 T11753 T11748 arg2Of enhanced,and
R10092 T11753 T11752 arg2Of enhanced,were
R10093 T11753 T11757 arg1Of enhanced,in
R10094 T11756 T11753 arg1Of FP,enhanced
R10095 T11756 T11754 arg2Of FP,by
R10096 T11756 T11755 arg2Of FP,inhaled
R10097 T11760 T11757 arg2Of manner,in
R10098 T11760 T11758 arg1Of manner,a
R10099 T11760 T11759 arg1Of manner,dose-dependent
R10100 T11760 T11761 arg1Of manner,(
R10101 T11760 T11790 arg1Of manner,(
R10102 T11762 T11761 arg2Of median,(
R10103 T11762 T11763 arg1Of median,[
R10104 T11762 T11768 arg1Of median,","
R10105 T11762 T11778 arg1Of median,","
R10106 T11764 T11765 arg1Of 95,%
R10107 T11766 T11763 arg2Of CI,[
R10108 T11766 T11764 arg1Of CI,95
R10109 T11767 T11763 arg3Of ],[
R10110 T11769 T11768 arg2Of 0.0032,","
R10111 T11769 T11770 arg1Of 0.0032,[
R10112 T11769 T11773 arg1Of 0.0032,versus
R10113 T11771 T11770 arg2Of 0.0026–0.0039,[
R10114 T11772 T11770 arg3Of ],[
R10115 T11774 T11773 arg2Of 0.658,versus
R10116 T11774 T11775 arg1Of 0.658,[
R10117 T11776 T11775 arg2Of 0.592–0.720,[
R10118 T11777 T11775 arg3Of ],[
R10119 T11779 T11778 arg2Of p,","
R10120 T11779 T11780 arg1Of p,<
R10121 T11779 T11781 arg1Of p,0.05
R10122 T11779 T11782 arg1Of p,","
R10123 T11779 T11784 arg1Of p,","
R10124 T11783 T11782 arg2Of W = −21.00,","
R10125 T11785 T11786 arg2Of Wilcoxon,'s
R10126 T11788 T11784 arg2Of test,","
R10127 T11788 T11786 arg1Of test,'s
R10128 T11788 T11787 arg1Of test,rank
R10129 T11789 T11761 arg3Of ),(
R10130 T11792 T11790 arg2Of 7D,(
R10131 T11792 T11791 arg1Of 7D,Figure
R10132 T11793 T11790 arg3Of ),(
R10133 T11795 T11794 arg2Of addition,In
R10134 T11797 T11798 arg1Of FP,(
R10135 T11797 T11802 arg1Of FP,inhibited
R10136 T11800 T11798 arg2Of µg,(
R10137 T11800 T11799 arg1Of µg,500
R10138 T11801 T11798 arg3Of ),(
R10139 T11802 T11794 arg1Of inhibited,In
R10140 T11802 T11796 arg1Of inhibited,","
R10141 T11802 T11806 arg1Of inhibited,in
R10142 T11802 T11811 arg1Of inhibited,vivo
R10143 T11802 T11812 arg1Of inhibited,at
R10144 T11802 T11815 arg1Of inhibited,in
R10145 T11805 T11802 arg2Of phosphorylation,inhibited
R10146 T11805 T11803 arg1Of phosphorylation,p38
R10147 T11805 T11804 arg1Of phosphorylation,MAPK
R10148 T11809 T11806 arg2Of cells,in
R10149 T11809 T11807 arg1Of cells,primary
R10150 T11809 T11808 arg1Of cells,T
R10151 T11811 T11810 arg1Of vivo,in
R10152 T11814 T11812 arg2Of h,at
R10153 T11814 T11813 arg1Of h,2
R10154 T11816 T11815 arg2Of samples,in
R10155 T11816 T11817 arg1Of samples,from
R10156 T11819 T11817 arg2Of patients,from
R10157 T11819 T11818 arg1Of patients,two
R10158 T11819 T11820 arg1Of patients,(
R10159 T11822 T11820 arg2Of 7E,(
R10160 T11822 T11821 arg1Of 7E,Figure
R10161 T11823 T11820 arg3Of ),(
R10162 T11824 T11825 arg1Of Taken,together
R10163 T11828 T11827 arg1Of data,our
R10164 T11828 T11829 arg1Of data,suggest
R10165 T11829 T11824 modOf suggest,Taken
R10166 T11829 T11826 arg1Of suggest,","
R10167 T11832 T11831 arg2Of FP,inhaled
R10168 T11832 T11833 arg1Of FP,reduces
R10169 T11833 T11829 arg2Of reduces,suggest
R10170 T11833 T11830 arg1Of reduces,that
R10171 T11833 T11839 arg1Of reduces,vivo
R10172 T11833 T11840 arg1Of reduces,by
R10173 T11835 T11833 arg2Of localization,reduces
R10174 T11835 T11834 arg1Of localization,nuclear
R10175 T11835 T11836 arg1Of localization,of
R10176 T11837 T11836 arg2Of GATA-3,of
R10177 T11839 T11838 arg1Of vivo,in
R10178 T11842 T11840 arg2Of inhibiting,by
R10179 T11842 T11841 arg1Of inhibiting,acutely
R10180 T11844 T11842 arg2Of association,inhibiting
R10181 T11844 T11843 arg1Of association,phospho-GATA-3–importin
R10182 T11846 T11845 arg1Of effect,This
R10183 T11846 T11847 arg1Of effect,may
R10184 T11846 T11848 arg1Of effect,be
R10185 T11846 T11849 arg1Of effect,direct
R10186 T11846 T11860 arg1Of effect,secondary
R10187 T11848 T11847 arg2Of be,may
R10188 T11849 T11850 arg1Of direct,","
R10189 T11849 T11851 arg1Of direct,through
R10190 T11849 T11859 arg1Of direct,or
R10191 T11852 T11851 arg2Of competition,through
R10192 T11852 T11853 arg1Of competition,for
R10193 T11854 T11855 arg1Of importin-α,or
R10194 T11855 T11853 arg2Of or,for
R10195 T11857 T11855 arg2Of molecules,or
R10196 T11857 T11856 arg2Of molecules,associated
R10197 T11859 T11848 arg2Of or,be
R10198 T11859 T11858 arg1Of or,","
R10199 T11860 T11859 arg2Of secondary,or
R10200 T11860 T11861 arg1Of secondary,to
R10201 T11863 T11861 arg2Of effect,to
R10202 T11863 T11862 arg1Of effect,an
R10203 T11863 T11864 arg1Of effect,on
R10204 T11863 T11869 arg1Of effect,via
R10205 T11868 T11864 arg2Of phosphorylation,on
R10206 T11868 T11865 arg1Of phosphorylation,p38
R10207 T11868 T11866 arg1Of phosphorylation,MAPK-mediated
R10208 T11868 T11867 arg1Of phosphorylation,GATA-3
R10209 T11871 T11869 arg2Of induction,via
R10210 T11871 T11870 arg1Of induction,rapid
R10211 T11871 T11872 arg1Of induction,of
R10212 T11873 T11872 arg2Of MKP-1,of
R10213 T11875 T11874 arg1Of combination,The
R10214 T11875 T11876 arg1Of combination,of
R10215 T11875 T11881 arg1Of combination,can
R10216 T11875 T11882 arg1Of combination,result
R10217 T11880 T11876 arg2Of effects,of
R10218 T11880 T11877 arg1Of effects,these
R10219 T11880 T11878 arg1Of effects,two
R10220 T11880 T11879 arg1Of effects,interacting
R10221 T11882 T11881 arg2Of result,can
R10222 T11882 T11883 arg1Of result,in
R10223 T11885 T11884 arg1Of suppression,complete
R10224 T11885 T11886 arg1Of suppression,of
R10225 T11885 T11890 arg1Of suppression,and
R10226 T11889 T11886 arg2Of import,of
R10227 T11889 T11887 arg1Of import,GATA-3
R10228 T11889 T11888 arg1Of import,nuclear
R10229 T11890 T11883 arg2Of and,in
R10230 T11895 T11890 arg2Of expression,and
R10231 T11895 T11891 arg1Of expression,thus
R10232 T11895 T11892 arg1Of expression,Th2
R10233 T11895 T11893 arg1Of expression,cytokine
R10234 T11895 T11894 arg1Of expression,gene
R13756 T16039 T16038 arg1Of propionate,Fluticasone
R13757 T16039 T16040 arg1Of propionate,down-regulates
R13758 T16039 T16046 arg1Of propionate,inhibits
R13759 T16040 T16045 arg1Of down-regulates,and
R13760 T16044 T16040 arg2Of expression,down-regulates
R13761 T16044 T16041 arg1Of expression,Th2
R13762 T16044 T16042 arg1Of expression,cytokine
R13763 T16044 T16043 arg1Of expression,gene
R13764 T16046 T16045 arg2Of inhibits,and
R13765 T16049 T16046 arg2Of import,inhibits
R13766 T16049 T16047 arg1Of import,GATA-3
R13767 T16049 T16048 arg1Of import,nuclear
R13768 T16051 T16050 arg2Of A,(
R13769 T16052 T16050 arg3Of ),(
R13770 T16054 T16050 arg1Of treatment,(
R13771 T16054 T16053 arg1Of treatment,Anti-CD3/CD28
R13772 T16054 T16055 arg1Of treatment,of
R13773 T16054 T16058 arg1Of treatment,results
R13774 T16057 T16055 arg2Of cells,of
R13775 T16057 T16056 arg1Of cells,HuT-78
R13776 T16058 T16059 arg1Of results,in
R13777 T16058 T16066 arg1Of results,to
R13778 T16058 T16069 arg1Of results,within
R13779 T16058 T16077 arg1Of results,and
R13780 T16060 T16059 arg2Of translocation,in
R13781 T16060 T16061 arg1Of translocation,of
R13782 T16062 T16061 arg2Of GATA-3,of
R13783 T16062 T16063 arg1Of GATA-3,from
R13784 T16065 T16063 arg2Of cytoplasm,from
R13785 T16065 T16064 arg1Of cytoplasm,the
R13786 T16068 T16066 arg2Of nucleus,to
R13787 T16068 T16067 arg1Of nucleus,the
R13788 T16071 T16070 arg1Of min.,30
R13789 T16071 T16072 arg1Of min.,(
R13790 T16073 T16072 arg2Of B,(
R13791 T16074 T16072 arg3Of ),(
R13792 T16076 T16069 arg2Of H1,within
R13793 T16076 T16071 arg1Of H1,min.
R13794 T16076 T16075 arg1Of H1,Histone
R13795 T16078 T16079 arg1Of MEK-1,were
R13796 T16078 T16080 arg2Of MEK-1,used
R13797 T16080 T16077 arg2Of used,and
R13798 T16080 T16079 arg2Of used,were
R13799 T16082 T16080 arg3Of confirm,used
R13800 T16082 T16081 arg1Of confirm,to
R13801 T16084 T16082 arg2Of separation,confirm
R13802 T16084 T16083 arg1Of separation,distinct
R13803 T16084 T16085 arg1Of separation,of
R13804 T16084 T16090 arg1Of separation,in
R13805 T16084 T16104 modOf separation,demonstrated
R13806 T16086 T16087 arg1Of cytoplasmic,and
R13807 T16088 T16087 arg2Of nuclear,and
R13808 T16089 T16085 arg2Of extracts,of
R13809 T16089 T16086 arg1Of extracts,cytoplasmic
R13810 T16089 T16088 arg1Of extracts,nuclear
R13811 T16093 T16090 arg2Of experiments.,in
R13812 T16093 T16091 arg1Of experiments.,three
R13813 T16093 T16092 arg1Of experiments.,separate
R13814 T16093 T16094 arg1Of experiments.,(
R13815 T16095 T16094 arg2Of C,(
R13816 T16096 T16094 arg3Of ),(
R13817 T16099 T16097 arg1Of analysis,Western
R13818 T16099 T16098 arg1Of analysis,blot
R13819 T16099 T16100 arg1Of analysis,of
R13820 T16099 T16104 arg1Of analysis,demonstrated
R13821 T16103 T16100 arg2Of cells,of
R13822 T16103 T16101 arg1Of cells,FP-treated
R13823 T16103 T16102 arg1Of cells,HuT-78
R13824 T16106 T16105 arg1Of nuclear,impaired
R13825 T16107 T16104 arg2Of localization,demonstrated
R13826 T16107 T16106 arg1Of localization,nuclear
R13827 T16107 T16108 arg1Of localization,of
R13828 T16109 T16108 arg2Of GATA-3,of
R13829 T16109 T16110 arg2Of GATA-3,induced
R13830 T16113 T16112 arg1Of co-stimulation,anti-CD3/CD28
R13831 T16113 T16114 arg1Of co-stimulation,in
R13832 T16113 T16123 arg1Of co-stimulation,and
R13833 T16116 T16114 arg2Of time-,in
R13834 T16116 T16115 arg1Of time-,a
R13835 T16116 T16117 arg1Of time-,(
R13836 T16118 T16117 arg2Of at,(
R13837 T16119 T16120 arg1Of 10−8,M
R13838 T16121 T16118 arg2Of FP,at
R13839 T16121 T16119 arg1Of FP,10−8
R13840 T16122 T16117 arg3Of ),(
R13841 T16123 T16110 arg1Of and,induced
R13842 T16123 T16111 arg2Of and,by
R13843 T16124 T16125 arg1Of concentration-,(
R13844 T16126 T16125 arg2Of at,(
R13845 T16128 T16126 arg2Of min,at
R13846 T16128 T16127 arg1Of min,60
R13847 T16128 T16129 arg1Of min,after
R13848 T16130 T16129 arg2Of stimulation,after
R13849 T16131 T16125 arg3Of ),(
R13850 T16133 T16123 arg2Of manner,and
R13851 T16133 T16124 arg1Of manner,concentration-
R13852 T16133 T16132 arg1Of manner,dependent
R13853 T16134 T16135 arg1Of Cells,were
R13854 T16134 T16136 arg2Of Cells,pretreated
R13855 T16136 T16135 arg2Of pretreated,were
R13856 T16136 T16137 arg1Of pretreated,with
R13857 T16138 T16137 arg2Of FP,with
R13858 T16138 T16139 arg1Of FP,for
R13859 T16141 T16139 arg2Of min,for
R13860 T16141 T16140 arg1Of min,30
R13861 T16141 T16142 arg1Of min,prior
R13862 T16142 T16143 arg1Of prior,to
R13863 T16144 T16143 arg2Of stimulation,to
R13864 T16145 T16146 arg1Of MEK1,and
R13865 T16146 T16149 arg1Of and,were
R13866 T16146 T16150 arg2Of and,used
R13867 T16148 T16146 arg2Of H1,and
R13868 T16148 T16147 arg1Of H1,histone
R13869 T16150 T16149 arg2Of used,were
R13870 T16152 T16150 arg3Of demonstrate,used
R13871 T16152 T16151 arg1Of demonstrate,to
R13872 T16152 T16158 arg1Of demonstrate,respectively
R13873 T16154 T16155 arg1Of cytoplasmic,and
R13874 T16156 T16155 arg2Of nuclear,and
R13875 T16157 T16152 arg2Of loading,demonstrate
R13876 T16157 T16153 arg1Of loading,equal
R13877 T16157 T16154 arg1Of loading,cytoplasmic
R13878 T16157 T16156 arg1Of loading,nuclear
R13879 T16159 T16160 arg1Of Results,are
R13880 T16159 T16161 arg2Of Results,presented
R13881 T16161 T16160 arg2Of presented,are
R13882 T16161 T16163 arg1Of presented,below
R13883 T16161 T16164 arg1Of presented,as
R13884 T16161 T16176 arg1Of presented,compared
R13885 T16163 T16162 arg1Of below,graphically
R13886 T16165 T16164 arg2Of mean±SEM,as
R13887 T16165 T16166 arg1Of mean±SEM,of
R13888 T16169 T16167 arg1Of three,at
R13889 T16169 T16168 arg1Of three,least
R13890 T16171 T16166 arg2Of experiments.,of
R13891 T16171 T16169 arg1Of experiments.,three
R13892 T16171 T16170 arg1Of experiments.,independent
R13893 T16173 T16164 arg3Of p,as
R13894 T16173 T16172 arg1Of p,***
R13895 T16173 T16174 arg1Of p,<
R13896 T16175 T16161 arg3Of 0.001,presented
R13897 T16177 T16176 arg2Of to,compared
R13898 T16180 T16179 arg2Of D,(
R13899 T16181 T16179 arg3Of ),(
R13900 T16182 T16177 arg2Of RT-PCR,to
R13901 T16182 T16178 arg1Of RT-PCR,t = 0.
R13902 T16182 T16179 arg1Of RT-PCR,(
R13903 T16182 T16183 arg1Of RT-PCR,showing
R13904 T16185 T16186 arg1Of FP,inhibits
R13905 T16186 T16183 arg2Of inhibits,showing
R13906 T16186 T16184 arg1Of inhibits,that
R13907 T16187 T16188 arg1Of IL-4,and
R13908 T16189 T16188 arg2Of IL-5,and
R13909 T16191 T16186 arg2Of expression,inhibits
R13910 T16191 T16187 arg1Of expression,IL-4
R13911 T16191 T16189 arg1Of expression,IL-5
R13912 T16191 T16190 arg1Of expression,mRNA
R13913 T16191 T16192 arg1Of expression,in
R13914 T16194 T16192 arg2Of cells,in
R13915 T16194 T16193 arg1Of cells,CD3/CD28-costimulated
R13916 T16195 T16196 arg1Of GAPDH,was
R13917 T16195 T16197 arg2Of GAPDH,used
R13918 T16197 T16196 arg2Of used,was
R13919 T16197 T16198 arg1Of used,as
R13920 T16201 T16198 arg2Of control,as
R13921 T16201 T16199 arg1Of control,a
R13922 T16201 T16200 arg1Of control,loading
R13923 T16203 T16202 arg1Of panels,Lower
R13924 T16203 T16204 arg1Of panels,show
R13925 T16203 T16228 arg1Of panels,***p
R13926 T16204 T16227 arg1Of show,","
R13927 T16204 T16228 modOf show,***p
R13928 T16206 T16204 arg2Of analysis,show
R13929 T16206 T16205 arg1Of analysis,graphical
R13930 T16206 T16207 arg1Of analysis,of
R13931 T16208 T16207 arg2Of results,of
R13932 T16208 T16209 arg2Of results,presented
R13933 T16209 T16210 arg1Of presented,as
R13934 T16211 T16210 arg2Of mean±SEM,as
R13935 T16211 T16212 arg1Of mean±SEM,of
R13936 T16215 T16213 arg1Of three,at
R13937 T16215 T16214 arg1Of three,least
R13938 T16217 T16215 arg1Of experiments.,three
R13939 T16217 T16216 arg1Of experiments.,independent
R13940 T16221 T16217 arg1Of p,experiments.
R13941 T16221 T16218 arg1Of p,#
R13942 T16221 T16219 arg1Of p,#
R13943 T16221 T16220 arg1Of p,#
R13944 T16221 T16222 arg1Of p,<
R13945 T16223 T16212 arg2Of 0.001,of
R13946 T16223 T16221 arg1Of 0.001,p
R13947 T16223 T16224 arg1Of 0.001,compared
R13948 T16225 T16224 arg2Of to,compared
R13949 T16226 T16225 arg2Of control,to
R13950 T16230 T16231 arg1Of 0.001,compared
R13951 T16232 T16231 arg2Of to,compared
R13952 T16233 T16232 arg2Of anti-CD3/CD28–stimulated.,to
R13953 T16233 T16234 arg1Of anti-CD3/CD28–stimulated.,(
R13954 T16235 T16234 arg2Of E,(
R13955 T16236 T16234 arg3Of ),(
R13956 T16237 T16229 arg1Of FP,<
R13957 T16237 T16230 arg1Of FP,0.001
R13958 T16237 T16238 arg1Of FP,(
R13959 T16237 T16242 arg1Of FP,reduces
R13960 T16240 T16238 arg2Of nM,(
R13961 T16240 T16239 arg1Of nM,10
R13962 T16241 T16238 arg3Of ),(
R13963 T16242 T16228 arg2Of reduces,***p
R13964 T16244 T16242 arg2Of ability,reduces
R13965 T16244 T16243 arg1Of ability,the
R13966 T16244 T16245 arg1Of ability,of
R13967 T16244 T16248 modOf ability,to
R13968 T16247 T16245 arg2Of GATA-3,of
R13969 T16247 T16246 arg1Of GATA-3,anti-CD3/CD28-stimulated
R13970 T16249 T16248 arg1Of associate,to
R13971 T16249 T16250 arg1Of associate,with
R13972 T16256 T16250 arg2Of min,with
R13973 T16256 T16251 arg1Of min,the
R13974 T16256 T16252 arg1Of min,native
R13975 T16256 T16253 arg1Of min,IL-5
R13976 T16256 T16254 arg1Of min,promoter
R13977 T16256 T16255 arg1Of min,60
R13978 T16256 T16257 arg1Of min,after
R13979 T16258 T16257 arg2Of stimulation,after
R13980 T16259 T16260 arg1Of Data,are
R13981 T16259 T16262 arg2Of Data,shown
R13982 T16262 T16260 arg2Of shown,are
R13983 T16262 T16261 arg1Of shown,also
R13984 T16262 T16263 arg1Of shown,graphically
R13985 T16262 T16264 arg1Of shown,as
R13986 T16265 T16264 arg2Of mean±SEM,as
R13987 T16265 T16266 arg1Of mean±SEM,of
R13988 T16269 T16266 arg2Of experiments,of
R13989 T16269 T16267 arg1Of experiments,three
R13990 T16269 T16268 arg1Of experiments,independent
R13991 T16271 T16270 arg1Of data,All
R13992 T16271 T16272 arg1Of data,were
R13993 T16271 T16273 arg2Of data,analysed
R13994 T16273 T16272 arg2Of analysed,were
R13995 T16275 T16273 arg1Of ANOVA,analysed
R13996 T16275 T16274 arg2Of ANOVA,by
R13997 T16275 T16276 arg2Of ANOVA,followed
R13998 T16278 T16276 arg1Of Newman-Keuls,followed
R13999 T16278 T16277 arg2Of Newman-Keuls,by
R14000 T16278 T16279 arg1Of Newman-Keuls,post-test
R14410 T16827 T16826 arg1Of propionate,Fluticasone
R14411 T16827 T16828 arg1Of propionate,reduces
R14412 T16830 T16828 arg2Of association,reduces
R14413 T16830 T16829 arg1Of association,GATA-3
R14414 T16830 T16831 arg1Of association,with
R14415 T16832 T16833 arg1Of importin-α,and
R14416 T16833 T16831 arg2Of and,with
R14417 T16836 T16833 arg2Of import,and
R14418 T16836 T16834 arg1Of import,GATA-3
R14419 T16836 T16835 arg1Of import,nuclear
R14420 T16838 T16837 arg2Of A,(
R14421 T16839 T16837 arg3Of ),(
R14422 T16842 T16837 arg1Of analysis,(
R14423 T16842 T16840 arg1Of analysis,Western
R14424 T16842 T16841 arg1Of analysis,blot
R14425 T16842 T16843 arg1Of analysis,demonstrates
R14426 T16845 T16844 arg1Of time-,a
R14427 T16845 T16846 arg1Of time-,(
R14428 T16845 T16852 arg1Of time-,and
R14429 T16847 T16846 arg2Of at,(
R14430 T16848 T16849 arg1Of 10−8,M
R14431 T16850 T16847 arg2Of FP,at
R14432 T16850 T16848 arg1Of FP,10−8
R14433 T16851 T16846 arg3Of ),(
R14434 T16852 T16843 arg2Of and,demonstrates
R14435 T16853 T16854 arg1Of concentration-,(
R14436 T16855 T16854 arg2Of at,(
R14437 T16857 T16855 arg2Of min,at
R14438 T16857 T16856 arg1Of min,60
R14439 T16857 T16858 arg1Of min,after
R14440 T16859 T16858 arg2Of stimulation,after
R14441 T16860 T16854 arg3Of ),(
R14442 T16862 T16852 arg2Of induction,and
R14443 T16862 T16853 arg1Of induction,concentration-
R14444 T16862 T16861 arg1Of induction,dependent
R14445 T16862 T16863 arg1Of induction,of
R14446 T16866 T16863 arg2Of interaction,of
R14447 T16866 T16864 arg1Of interaction,FP-activated
R14448 T16866 T16865 arg1Of interaction,GR
R14449 T16866 T16867 arg1Of interaction,with
R14450 T16868 T16867 arg2Of importin-α,with
R14451 T16868 T16869 arg1Of importin-α,(
R14452 T16870 T16869 arg2Of Imp-α,(
R14453 T16871 T16869 arg3Of ),(
R14454 T16874 T16872 arg1Of control,A
R14455 T16874 T16873 arg1Of control,positive
R14456 T16874 T16875 arg1Of control,for
R14457 T16874 T16880 arg1Of control,is
R14458 T16874 T16881 arg2Of control,shown
R14459 T16877 T16875 arg2Of association,for
R14460 T16877 T16876 arg1Of association,GR
R14461 T16877 T16878 arg1Of association,with
R14462 T16879 T16878 arg2Of importin,with
R14463 T16881 T16880 arg2Of shown,is
R14464 T16882 T16883 arg1Of Quantification,of
R14465 T16882 T16887 arg1Of Quantification,is
R14466 T16882 T16888 arg2Of Quantification,shown
R14467 T16886 T16883 arg2Of data,of
R14468 T16886 T16884 arg1Of data,the
R14469 T16886 T16885 arg1Of data,densitometry
R14470 T16888 T16887 arg2Of shown,is
R14471 T16888 T16889 arg1Of shown,below
R14472 T16891 T16890 arg1Of bar,Each
R14473 T16891 T16892 arg1Of bar,represents
R14474 T16893 T16892 arg2Of mean±SEM,represents
R14475 T16893 T16894 arg1Of mean±SEM,of
R14476 T16897 T16895 arg1Of three,at
R14477 T16897 T16896 arg1Of three,least
R14478 T16899 T16894 arg2Of experiments.,of
R14479 T16899 T16897 arg1Of experiments.,three
R14480 T16899 T16898 arg1Of experiments.,independent
R14481 T16902 T16900 arg1Of <,***
R14482 T16902 T16901 arg1Of <,p
R14483 T16903 T16892 arg3Of 0.001,represents
R14484 T16903 T16902 arg1Of 0.001,<
R14485 T16903 T16904 arg1Of 0.001,compared
R14486 T16903 T16945 arg2Of 0.001,measured
R14487 T16905 T16904 arg2Of to,compared
R14488 T16906 T16905 arg2Of control,to
R14489 T16906 T16907 arg1Of control,","
R14490 T16906 T16912 arg1Of control,<
R14491 T16911 T16907 arg2Of p,","
R14492 T16911 T16908 arg1Of p,#
R14493 T16911 T16909 arg1Of p,#
R14494 T16911 T16910 arg1Of p,#
R14495 T16915 T16914 arg2Of B,(
R14496 T16916 T16914 arg3Of ),(
R14497 T16919 T16913 arg1Of analysis,0.001.
R14498 T16919 T16914 arg1Of analysis,(
R14499 T16919 T16917 arg1Of analysis,Western
R14500 T16919 T16918 arg1Of analysis,blot
R14501 T16919 T16920 arg1Of analysis,demonstrated
R14502 T16922 T16921 arg1Of time-,a
R14503 T16922 T16923 arg1Of time-,(
R14504 T16922 T16929 arg1Of time-,and
R14505 T16924 T16923 arg2Of at,(
R14506 T16925 T16926 arg1Of 10−8,M
R14507 T16927 T16924 arg2Of FP,at
R14508 T16927 T16925 arg1Of FP,10−8
R14509 T16928 T16923 arg3Of ),(
R14510 T16929 T16920 arg2Of and,demonstrated
R14511 T16930 T16931 arg1Of concentration-,(
R14512 T16932 T16931 arg2Of at,(
R14513 T16934 T16932 arg2Of min,at
R14514 T16934 T16933 arg1Of min,60
R14515 T16934 T16935 arg1Of min,after
R14516 T16936 T16935 arg2Of stimulation,after
R14517 T16937 T16931 arg3Of ),(
R14518 T16939 T16929 arg2Of induction,and
R14519 T16939 T16930 arg1Of induction,concentration-
R14520 T16939 T16938 arg1Of induction,dependent
R14521 T16939 T16940 arg1Of induction,of
R14522 T16944 T16940 arg2Of translocation,of
R14523 T16944 T16941 arg1Of translocation,FP-activated
R14524 T16944 T16942 arg1Of translocation,GR
R14525 T16944 T16943 arg1Of translocation,nuclear
R14526 T16945 T16920 arg3Of measured,demonstrated
R14527 T16947 T16945 arg1Of IP,measured
R14528 T16947 T16946 arg2Of IP,by
R14529 T16948 T16949 arg1Of Quantification,of
R14530 T16948 T16953 arg1Of Quantification,is
R14531 T16948 T16954 arg2Of Quantification,shown
R14532 T16952 T16949 arg2Of data,of
R14533 T16952 T16950 arg1Of data,the
R14534 T16952 T16951 arg1Of data,densitometry
R14535 T16954 T16953 arg2Of shown,is
R14536 T16954 T16955 arg1Of shown,below
R14537 T16957 T16956 arg1Of bar,Each
R14538 T16957 T16958 arg1Of bar,represents
R14539 T16958 T16984 arg1Of represents,and
R14540 T16959 T16958 arg2Of mean±SEM,represents
R14541 T16959 T16960 arg1Of mean±SEM,of
R14542 T16963 T16961 arg1Of three,at
R14543 T16963 T16962 arg1Of three,least
R14544 T16965 T16963 arg1Of experiments.,three
R14545 T16965 T16964 arg1Of experiments.,independent
R14546 T16965 T16966 arg1Of experiments.,***p
R14547 T16966 T16969 arg1Of ***p,compared
R14548 T16968 T16966 arg2Of 0.001,***p
R14549 T16968 T16967 arg1Of 0.001,<
R14550 T16970 T16969 arg2Of to,compared
R14551 T16971 T16970 arg2Of control.,to
R14552 T16971 T16972 arg1Of control.,(
R14553 T16973 T16972 arg2Of C,(
R14554 T16974 T16972 arg3Of ),(
R14555 T16977 T16960 arg2Of analysis,of
R14556 T16977 T16965 arg1Of analysis,experiments.
R14557 T16977 T16975 arg1Of analysis,Western
R14558 T16977 T16976 arg1Of analysis,blot
R14559 T16977 T16978 arg1Of analysis,of
R14560 T16980 T16978 arg2Of cells,of
R14561 T16980 T16979 arg1Of cells,HuT-78
R14562 T16980 T16981 arg2Of cells,treated
R14563 T16981 T16982 arg1Of treated,with
R14564 T16983 T16982 arg2Of FP,with
R14565 T16986 T16985 arg1Of co-stimulation,anti-CD3/CD28
R14566 T16986 T16987 arg1Of co-stimulation,demonstrated
R14567 T16987 T16984 arg2Of demonstrated,and
R14568 T16987 T16994 arg1Of demonstrated,at
R14569 T16990 T16987 arg2Of decrease,demonstrated
R14570 T16990 T16988 arg1Of decrease,a
R14571 T16990 T16989 arg1Of decrease,concentration-dependent
R14572 T16990 T16991 arg1Of decrease,in
R14573 T16993 T16991 arg2Of association,in
R14574 T16993 T16992 arg1Of association,GATA-3–importin-α
R14575 T16996 T16994 arg2Of min,at
R14576 T16996 T16995 arg1Of min,20
R14577 T16997 T16998 arg1Of Quantification,of
R14578 T16997 T17002 arg1Of Quantification,is
R14579 T16997 T17003 arg2Of Quantification,shown
R14580 T17001 T16998 arg2Of data,of
R14581 T17001 T16999 arg1Of data,the
R14582 T17001 T17000 arg1Of data,densitometry
R14583 T17003 T17002 arg2Of shown,is
R14584 T17003 T17004 arg1Of shown,below
R14585 T17006 T17005 arg1Of bar,Each
R14586 T17006 T17007 arg1Of bar,represents
R14587 T17006 T17025 arg1Of bar,***p
R14588 T17007 T17020 arg1Of represents,0.001
R14589 T17007 T17021 arg1Of represents,compared
R14590 T17007 T17024 arg1Of represents,","
R14591 T17007 T17025 modOf represents,***p
R14592 T17008 T17007 arg2Of mean±SEM,represents
R14593 T17008 T17009 arg1Of mean±SEM,of
R14594 T17012 T17010 arg1Of three,at
R14595 T17012 T17011 arg1Of three,least
R14596 T17014 T17009 arg2Of experiments.,of
R14597 T17014 T17012 arg1Of experiments.,three
R14598 T17014 T17013 arg1Of experiments.,independent
R14599 T17018 T17015 arg1Of p,#
R14600 T17018 T17016 arg1Of p,#
R14601 T17018 T17017 arg1Of p,#
R14602 T17018 T17019 arg1Of p,<
R14603 T17020 T17018 arg1Of 0.001,p
R14604 T17022 T17021 arg2Of to,compared
R14605 T17023 T17022 arg2Of control,to
R14606 T17027 T17028 arg1Of 0.001,compared
R14607 T17029 T17028 arg2Of to,compared
R14608 T17031 T17029 arg2Of cells.,to
R14609 T17031 T17030 arg1Of cells.,αCD3/CD28-stimulated
R14610 T17031 T17032 arg1Of cells.,(
R14611 T17033 T17032 arg2Of D,(
R14612 T17034 T17032 arg3Of ),(
R14613 T17036 T17026 arg1Of GATA-3,<
R14614 T17036 T17027 arg1Of GATA-3,0.001
R14615 T17036 T17035 arg1Of GATA-3,GFP-tagged
R14616 T17036 T17037 arg1Of GATA-3,was
R14617 T17036 T17038 arg2Of GATA-3,overexpressed
R14618 T17038 T17025 arg2Of overexpressed,***p
R14619 T17038 T17037 arg2Of overexpressed,was
R14620 T17040 T17039 arg1Of cells,and
R14621 T17040 T17041 arg2Of cells,stimulated
R14622 T17040 T17042 arg1Of cells,(
R14623 T17040 T17047 arg1Of cells,or
R14624 T17043 T17042 arg2Of b,(
R14625 T17043 T17044 arg1Of b,","
R14626 T17045 T17044 arg2Of c,","
R14627 T17046 T17042 arg3Of ),(
R14628 T17047 T17007 arg3Of or,represents
R14629 T17047 T17048 arg1Of or,not
R14630 T17050 T17051 arg1Of a,)
R14631 T17050 T17052 arg1Of a,for
R14632 T17054 T17052 arg2Of min,for
R14633 T17054 T17053 arg1Of min,30
R14634 T17056 T17047 arg2Of anti-CD3/CD28,or
R14635 T17056 T17049 arg1Of anti-CD3/CD28,(
R14636 T17056 T17050 arg1Of anti-CD3/CD28,a
R14637 T17056 T17055 arg1Of anti-CD3/CD28,with
R14638 T17058 T17057 arg1Of effect,The
R14639 T17058 T17059 arg1Of effect,of
R14640 T17058 T17073 arg1Of effect,is
R14641 T17058 T17075 arg2Of effect,shown
R14642 T17062 T17059 arg2Of pretreatment,of
R14643 T17062 T17060 arg1Of pretreatment,30
R14644 T17062 T17061 arg1Of pretreatment,min
R14645 T17062 T17063 arg1Of pretreatment,of
R14646 T17062 T17065 arg1Of pretreatment,with
R14647 T17064 T17063 arg2Of cells,of
R14648 T17066 T17065 arg2Of FP,with
R14649 T17066 T17067 arg1Of FP,(
R14650 T17069 T17067 arg2Of M,(
R14651 T17069 T17068 arg1Of M,10−8
R14652 T17069 T17070 arg1Of M,","
R14653 T17071 T17070 arg2Of c,","
R14654 T17072 T17067 arg3Of ),(
R14655 T17075 T17073 arg2Of shown,is
R14656 T17075 T17074 arg1Of shown,also
R14657 T17077 T17076 arg1Of data,All
R14658 T17077 T17078 arg1Of data,were
R14659 T17077 T17079 arg2Of data,analysed
R14660 T17079 T17078 arg2Of analysed,were
R14661 T17081 T17079 arg1Of ANOVA,analysed
R14662 T17081 T17080 arg2Of ANOVA,by
R14663 T17081 T17082 arg2Of ANOVA,followed
R14664 T17084 T17082 arg1Of Newman-Keuls,followed
R14665 T17084 T17083 arg2Of Newman-Keuls,by
R14666 T17084 T17085 arg1Of Newman-Keuls,post-test
R15109 T17625 T17624 arg1Of down-regulation,marked
R15094 T17610 T17611 arg1Of Fluticasone,propionate–mediated
R15095 T17611 T17618 arg1Of propionate–mediated,and
R15096 T17612 T17611 arg2Of inhibition,propionate–mediated
R15097 T17612 T17613 arg1Of inhibition,of
R15098 T17617 T17613 arg2Of phosphorylation,of
R15099 T17617 T17614 arg1Of phosphorylation,p38
R15100 T17617 T17615 arg1Of phosphorylation,MAP
R15101 T17617 T17616 arg1Of phosphorylation,kinase
R15102 T17619 T17620 arg1Of activation,is
R15103 T17619 T17621 arg2Of activation,associated
R15104 T17621 T17618 arg2Of associated,and
R15105 T17621 T17620 arg2Of associated,is
R15106 T17621 T17622 arg1Of associated,with
R15107 T17625 T17622 arg2Of down-regulation,with
R15108 T17625 T17623 arg1Of down-regulation,a
R15110 T17625 T17626 arg1Of down-regulation,of
R15111 T17629 T17626 arg2Of phosphorylation,of
R15112 T17629 T17627 arg1Of phosphorylation,GATA-3
R15113 T17629 T17628 arg1Of phosphorylation,serine
R15114 T17631 T17630 arg2Of A,(
R15115 T17632 T17630 arg3Of ),(
R15116 T17635 T17630 arg1Of analysis,(
R15117 T17635 T17633 arg1Of analysis,Western
R15118 T17635 T17634 arg1Of analysis,blot
R15119 T17635 T17636 arg1Of analysis,shows
R15120 T17638 T17639 arg1Of FP,(
R15121 T17641 T17639 arg2Of M,(
R15122 T17641 T17640 arg1Of M,10−8
R15123 T17641 T17642 arg1Of M,","
R15124 T17644 T17642 arg2Of min,","
R15125 T17644 T17643 arg1Of min,30
R15126 T17645 T17639 arg3Of ),(
R15127 T17646 T17638 arg1Of treatment,FP
R15128 T17646 T17647 arg1Of treatment,reduced
R15129 T17647 T17636 arg2Of reduced,shows
R15130 T17647 T17637 arg1Of reduced,that
R15131 T17649 T17647 arg2Of phosphorylation,reduced
R15132 T17649 T17648 arg1Of phosphorylation,dual
R15133 T17649 T17650 arg1Of phosphorylation,(
R15134 T17651 T17652 arg1Of threonine-180,and
R15135 T17652 T17650 arg2Of and,(
R15136 T17653 T17652 arg2Of tyrosine-182,and
R15137 T17654 T17650 arg3Of ),(
R15138 T17657 T17655 arg2Of MAPK,of
R15139 T17657 T17656 arg1Of MAPK,p38
R15140 T17661 T17658 arg2Of cells.,in
R15141 T17661 T17659 arg1Of cells.,anti-CD3/CD28–co-stimulated
R15142 T17661 T17660 arg1Of cells.,HuT-78
R15143 T17661 T17662 arg1Of cells.,(
R15144 T17663 T17662 arg2Of B,(
R15145 T17664 T17662 arg3Of ),(
R15146 T17666 T17665 arg1Of course,Time
R15147 T17666 T17667 arg1Of course,of
R15148 T17666 T17702 arg1Of course,is
R15149 T17666 T17703 arg2Of course,associated
R15150 T17669 T17667 arg2Of effect,of
R15151 T17669 T17668 arg1Of effect,the
R15152 T17669 T17670 arg1Of effect,of
R15153 T17669 T17676 arg1Of effect,on
R15154 T17669 T17678 arg1Of effect,of
R15155 T17671 T17670 arg2Of FP,of
R15156 T17671 T17672 arg1Of FP,(
R15157 T17674 T17672 arg2Of M,(
R15158 T17674 T17673 arg1Of M,10−8
R15159 T17675 T17672 arg3Of ),(
R15160 T17677 T17676 arg2Of phosphorylation,on
R15161 T17681 T17678 arg2Of factor,of
R15162 T17681 T17679 arg2Of factor,activated
R15163 T17681 T17680 arg1Of factor,transcription
R15164 T17681 T17682 arg1Of factor,2
R15165 T17681 T17683 arg1Of factor,(
R15166 T17681 T17686 arg1Of factor,","
R15167 T17684 T17683 arg2Of ATF-2,(
R15168 T17685 T17683 arg3Of ),(
R15169 T17688 T17686 arg2Of measure,","
R15170 T17688 T17687 arg1Of measure,a
R15171 T17688 T17689 arg1Of measure,of
R15172 T17694 T17693 arg2Of C,(
R15173 T17695 T17693 arg3Of ),(
R15174 T17697 T17689 arg2Of inhibition,of
R15175 T17697 T17690 arg1Of inhibition,p38
R15176 T17697 T17691 arg1Of inhibition,MAPK
R15177 T17697 T17692 arg1Of inhibition,activity.
R15178 T17697 T17693 arg1Of inhibition,(
R15179 T17697 T17696 arg1Of inhibition,FP-induced
R15180 T17697 T17698 arg1Of inhibition,of
R15181 T17701 T17698 arg2Of activity,of
R15182 T17701 T17699 arg1Of activity,p38
R15183 T17701 T17700 arg1Of activity,MAPK
R15184 T17703 T17702 arg2Of associated,is
R15185 T17703 T17704 arg1Of associated,with
R15186 T17706 T17704 arg2Of decrease,with
R15187 T17706 T17705 arg1Of decrease,the
R15188 T17706 T17707 arg1Of decrease,of
R15189 T17711 T17707 arg2Of phosphorylation,of
R15190 T17711 T17708 arg1Of phosphorylation,anti-CD3/CD28
R15191 T17711 T17709 arg1Of phosphorylation,co-stimulation–induced
R15192 T17711 T17710 arg1Of phosphorylation,serine
R15193 T17711 T17712 arg1Of phosphorylation,(
R15194 T17711 T17715 arg1Of phosphorylation,of
R15195 T17713 T17712 arg2Of P-Ser,(
R15196 T17714 T17712 arg3Of ),(
R15197 T17716 T17715 arg2Of GATA-3,of
R15198 T17719 T17717 arg2Of A–C,For
R15199 T17719 T17718 arg2Of A–C,(
R15200 T17720 T17718 arg3Of ),(
R15201 T17722 T17723 arg1Of quantification,of
R15202 T17722 T17727 arg1Of quantification,is
R15203 T17722 T17729 arg2Of quantification,shown
R15204 T17726 T17723 arg2Of data,of
R15205 T17726 T17724 arg1Of data,the
R15206 T17726 T17725 arg1Of data,densitometry
R15207 T17729 T17717 arg1Of shown,For
R15208 T17729 T17721 arg1Of shown,","
R15209 T17729 T17727 arg2Of shown,is
R15210 T17729 T17728 arg1Of shown,also
R15211 T17731 T17730 arg1Of bar,Each
R15212 T17731 T17732 arg1Of bar,represents
R15213 T17731 T17750 arg1Of bar,***p
R15214 T17732 T17750 modOf represents,***p
R15215 T17733 T17732 arg2Of mean±SEM,represents
R15216 T17733 T17734 arg1Of mean±SEM,of
R15217 T17737 T17735 arg1Of three,at
R15218 T17737 T17736 arg1Of three,least
R15219 T17739 T17737 arg1Of experiments.,three
R15220 T17739 T17738 arg1Of experiments.,independent
R15221 T17743 T17734 arg2Of p,of
R15222 T17743 T17739 arg1Of p,experiments.
R15223 T17743 T17740 arg1Of p,#
R15224 T17743 T17741 arg1Of p,#
R15225 T17743 T17742 arg1Of p,#
R15226 T17745 T17732 arg3Of 0.001,represents
R15227 T17745 T17744 arg1Of 0.001,<
R15228 T17745 T17746 arg1Of 0.001,compared
R15229 T17747 T17746 arg2Of to,compared
R15230 T17748 T17747 arg2Of control,to
R15231 T17750 T17749 arg1Of ***p,","
R15232 T17752 T17753 arg1Of 0.001,compared
R15233 T17754 T17753 arg2Of to,compared
R15234 T17756 T17754 arg2Of cells.,to
R15235 T17756 T17755 arg1Of cells.,αCD3/CD28-stimulated
R15236 T17756 T17757 arg1Of cells.,(
R15237 T17758 T17757 arg2Of D,(
R15238 T17759 T17757 arg3Of ),(
R15239 T17760 T17751 arg1Of FP,<
R15240 T17760 T17752 arg1Of FP,0.001
R15241 T17760 T17761 arg1Of FP,induced
R15242 T17761 T17750 arg2Of induced,***p
R15243 T17761 T17764 arg1Of induced,in
R15244 T17763 T17761 arg2Of mRNA,induced
R15245 T17763 T17762 arg1Of mRNA,MKP-1
R15246 T17767 T17764 arg2Of manner,in
R15247 T17767 T17765 arg1Of manner,a
R15248 T17767 T17766 arg1Of manner,concentration-dependent
R15249 T17769 T17768 arg1Of results,All
R15250 T17769 T17770 arg1Of results,are
R15251 T17769 T17771 arg1Of results,representative
R15252 T17771 T17770 arg2Of representative,are
R15253 T17771 T17772 arg1Of representative,of
R15254 T17775 T17773 arg1Of three,at
R15255 T17775 T17774 arg1Of three,least
R15256 T17777 T17775 arg1Of experiments,three
R15257 T17777 T17776 arg1Of experiments,independent
R15258 T17777 T17778 arg1Of experiments,and
R15259 T17778 T17772 arg2Of and,of
R15260 T17779 T17778 arg2Of where,and
R15261 T17781 T17782 arg1Of expressed,as
R15262 T17783 T17782 arg2Of means±SEM,as
R15263 T17783 T17784 arg1Of means±SEM,","
R15264 T17785 T17784 arg2Of *p,","
R15265 T17785 T17786 arg1Of *p,<
R15266 T17789 T17788 arg2Of E,(
R15267 T17790 T17788 arg3Of ),(
R15268 T17791 T17780 arg1Of FP,appropriate
R15269 T17791 T17781 arg2Of FP,expressed
R15270 T17791 T17787 arg1Of FP,0.05.
R15271 T17791 T17788 arg1Of FP,(
R15272 T17791 T17792 arg1Of FP,induces
R15273 T17792 T17779 arg1Of induces,where
R15274 T17792 T17795 arg1Of induces,in
R15275 T17794 T17792 arg2Of mRNA,induces
R15276 T17794 T17793 arg1Of mRNA,MKP-1
R15277 T17798 T17795 arg2Of manner,in
R15278 T17798 T17796 arg1Of manner,a
R15279 T17798 T17797 arg1Of manner,time-dependent
R15280 T17799 T17800 arg1Of Results,are
R15281 T17799 T17801 arg1Of Results,representative
R15282 T17801 T17800 arg2Of representative,are
R15283 T17801 T17802 arg1Of representative,of
R15284 T17805 T17802 arg2Of experiments,of
R15285 T17805 T17803 arg1Of experiments,two
R15286 T17805 T17804 arg1Of experiments,independent
R15287 T17807 T17806 arg1Of data,All
R15288 T17807 T17808 arg1Of data,except
R15289 T17807 T17809 arg1Of data,(
R15290 T17807 T17812 arg1Of data,were
R15291 T17807 T17813 arg2Of data,analysed
R15292 T17810 T17809 arg2Of E,(
R15293 T17811 T17809 arg3Of ),(
R15294 T17813 T17812 arg2Of analysed,were
R15295 T17815 T17813 arg1Of ANOVA,analysed
R15296 T17815 T17814 arg2Of ANOVA,by
R15297 T17815 T17816 arg2Of ANOVA,followed
R15298 T17818 T17816 arg1Of Newman-Keuls,followed
R15299 T17818 T17817 arg2Of Newman-Keuls,by
R15300 T17818 T17819 arg1Of Newman-Keuls,post-test
R15975 T18719 T18718 arg1Of propionate,Fluticasone
R15976 T18719 T18720 arg1Of propionate,does
R15977 T18719 T18722 arg1Of propionate,affect
R15978 T18722 T18720 arg2Of affect,does
R15979 T18722 T18721 arg1Of affect,not
R15980 T18725 T18722 arg2Of export,affect
R15981 T18725 T18723 arg1Of export,GATA-3
R15982 T18725 T18724 arg1Of export,nuclear
R15983 T18727 T18726 arg2Of A,(
R15984 T18728 T18726 arg3Of ),(
R15985 T18731 T18726 arg1Of analysis,(
R15986 T18731 T18729 arg1Of analysis,Western
R15987 T18731 T18730 arg1Of analysis,blot
R15988 T18731 T18732 arg1Of analysis,showing
R15989 T18731 T18815 arg1Of analysis,(
R15990 T18731 T18818 arg1Of analysis,or
R15991 T18739 T18734 arg1Of B,the
R15992 T18739 T18735 arg1Of B,nuclear
R15993 T18739 T18736 arg1Of B,export
R15994 T18739 T18737 arg1Of B,inhibitor
R15995 T18739 T18738 arg1Of B,leptomycin
R15996 T18739 T18740 arg1Of B,(
R15997 T18739 T18744 arg1Of B,does
R15998 T18739 T18746 arg1Of B,affect
R15999 T18742 T18740 arg2Of nM,(
R16000 T18742 T18741 arg1Of nM,2
R16001 T18743 T18740 arg3Of ),(
R16002 T18746 T18744 arg2Of affect,does
R16003 T18746 T18745 arg1Of affect,not
R16004 T18746 T18772 arg1Of affect,","
R16005 T18748 T18746 arg2Of ability,affect
R16006 T18748 T18747 arg1Of ability,the
R16007 T18748 T18749 arg1Of ability,of
R16008 T18748 T18755 modOf ability,to
R16009 T18748 T18756 arg1Of ability,prevent
R16010 T18750 T18749 arg2Of FP,of
R16011 T18750 T18751 arg1Of FP,(
R16012 T18753 T18751 arg2Of M,(
R16013 T18753 T18752 arg1Of M,10−8
R16014 T18754 T18751 arg3Of ),(
R16015 T18756 T18755 arg1Of prevent,to
R16016 T18760 T18756 arg2Of localization,prevent
R16017 T18760 T18757 arg1Of localization,anti-CD3/CD28–stimulated
R16018 T18760 T18758 arg1Of localization,GATA-3
R16019 T18760 T18759 arg1Of localization,nuclear
R16020 T18760 T18761 arg2Of localization,measured
R16021 T18760 T18768 arg1Of localization,compared
R16022 T18761 T18762 arg1Of measured,at
R16023 T18765 T18766 arg1Of ***p,<
R16024 T18767 T18762 arg2Of 0.001,at
R16025 T18767 T18763 arg1Of 0.001,60
R16026 T18767 T18764 arg1Of 0.001,min.
R16027 T18767 T18765 arg1Of 0.001,***p
R16028 T18769 T18768 arg2Of to,compared
R16029 T18771 T18769 arg2Of cells,to
R16030 T18771 T18770 arg1Of cells,unstimulated
R16031 T18772 T18732 arg2Of ",",showing
R16032 T18772 T18733 arg1Of ",",that
R16033 T18777 T18778 arg1Of <,0.001
R16034 T18777 T18779 arg1Of <,compared
R16035 T18780 T18779 arg2Of to,compared
R16036 T18782 T18780 arg2Of cells.,to
R16037 T18782 T18781 arg1Of cells.,anti-CD3/CD28–stimulated
R16038 T18782 T18783 arg1Of cells.,(
R16039 T18784 T18783 arg2Of B,(
R16040 T18785 T18783 arg3Of ),(
R16041 T18788 T18773 arg1Of analysis,#
R16042 T18788 T18774 arg1Of analysis,#
R16043 T18788 T18775 arg1Of analysis,#
R16044 T18788 T18776 arg1Of analysis,p
R16045 T18788 T18777 arg1Of analysis,<
R16046 T18788 T18786 arg1Of analysis,Western
R16047 T18788 T18787 arg1Of analysis,blot
R16048 T18788 T18789 arg1Of analysis,showing
R16049 T18788 T18810 arg1Of analysis,is
R16050 T18788 T18811 arg2Of analysis,overexpressed
R16051 T18791 T18792 arg1Of FP,(
R16052 T18791 T18796 arg1Of FP,does
R16053 T18791 T18798 arg1Of FP,affect
R16054 T18794 T18792 arg2Of M,(
R16055 T18794 T18793 arg1Of M,10−8
R16056 T18795 T18792 arg3Of ),(
R16057 T18798 T18789 arg2Of affect,showing
R16058 T18798 T18790 arg1Of affect,that
R16059 T18798 T18796 arg2Of affect,does
R16060 T18798 T18797 arg1Of affect,not
R16061 T18798 T18802 arg1Of affect,over
R16062 T18801 T18798 arg2Of degradation,affect
R16063 T18801 T18799 arg1Of degradation,whole-cell
R16064 T18801 T18800 arg1Of degradation,GATA-3
R16065 T18806 T18805 arg2Of C,(
R16066 T18807 T18805 arg3Of ),(
R16067 T18808 T18804 arg1Of GFP-tagged,h.
R16068 T18808 T18805 arg1Of GFP-tagged,(
R16069 T18809 T18802 arg2Of GATA-3,over
R16070 T18809 T18803 arg1Of GATA-3,17
R16071 T18809 T18808 arg1Of GATA-3,GFP-tagged
R16072 T18811 T18810 arg2Of overexpressed,is
R16073 T18811 T18812 arg1Of overexpressed,and
R16074 T18812 T18772 arg2Of and,","
R16075 T18813 T18814 arg1Of cells,stimulated
R16076 T18814 T18812 arg2Of stimulated,and
R16077 T18816 T18815 arg2Of b–j,(
R16078 T18817 T18815 arg3Of ),(
R16079 T18818 T18819 arg1Of or,not
R16080 T18824 T18818 arg2Of anti-CD3/CD28,or
R16081 T18824 T18820 arg1Of anti-CD3/CD28,(
R16082 T18824 T18821 arg1Of anti-CD3/CD28,a
R16083 T18824 T18822 arg1Of anti-CD3/CD28,)
R16084 T18824 T18823 arg1Of anti-CD3/CD28,with
R16085 T18826 T18825 arg1Of effect,The
R16086 T18826 T18827 arg1Of effect,of
R16087 T18826 T18855 arg1Of effect,does
R16088 T18826 T18857 arg1Of effect,prevent
R16089 T18828 T18827 arg2Of treating,of
R16090 T18828 T18830 arg1Of treating,with
R16091 T18828 T18838 arg1Of treating,after
R16092 T18829 T18828 arg2Of cells,treating
R16093 T18831 T18830 arg2Of FP,with
R16094 T18831 T18832 arg1Of FP,(
R16095 T18834 T18832 arg2Of M,(
R16096 T18834 T18833 arg1Of M,10−8
R16097 T18834 T18835 arg1Of M,","
R16098 T18836 T18835 arg2Of f–j,","
R16099 T18837 T18832 arg3Of ),(
R16100 T18841 T18839 arg1Of stimulation,30
R16101 T18841 T18840 arg1Of stimulation,min
R16102 T18841 T18842 arg1Of stimulation,with
R16103 T18841 T18844 arg1Of stimulation,is
R16104 T18843 T18842 arg2Of anti-CD3/CD28,with
R16105 T18844 T18838 arg2Of is,after
R16106 T18844 T18845 arg1Of is,also
R16107 T18844 T18850 arg1Of is,FP
R16108 T18846 T18844 arg2Of shown.,is
R16109 T18846 T18847 arg1Of shown.,(
R16110 T18848 T18847 arg2Of D,(
R16111 T18849 T18847 arg3Of ),(
R16112 T18850 T18851 arg1Of FP,(
R16113 T18853 T18851 arg2Of M,(
R16114 T18853 T18852 arg1Of M,10−8
R16115 T18854 T18851 arg3Of ),(
R16116 T18857 T18855 arg2Of prevent,does
R16117 T18857 T18856 arg1Of prevent,not
R16118 T18857 T18862 arg1Of prevent,at
R16119 T18857 T18865 arg1Of prevent,after
R16120 T18857 T18870 arg1Of prevent,compared
R16121 T18861 T18857 arg2Of translocation,prevent
R16122 T18861 T18858 arg1Of translocation,anti-CD3/CD28–stimulated
R16123 T18861 T18859 arg1Of translocation,p65
R16124 T18861 T18860 arg1Of translocation,nuclear
R16125 T18864 T18862 arg2Of min,at
R16126 T18864 T18863 arg1Of min,60
R16127 T18867 T18868 arg1Of **p,<
R16128 T18869 T18865 arg2Of 0.01,after
R16129 T18869 T18866 arg1Of 0.01,stimulation.
R16130 T18869 T18867 arg1Of 0.01,**p
R16131 T18871 T18870 arg2Of to,compared
R16132 T18873 T18871 arg2Of cells,to
R16133 T18873 T18872 arg1Of cells,unstimulated
R16134 T18875 T18874 arg1Of results,All
R16135 T18875 T18876 arg1Of results,are
R16136 T18875 T18877 arg1Of results,representative
R16137 T18875 T18885 arg1Of results,are
R16138 T18875 T18886 arg2Of results,shown
R16139 T18876 T18884 arg1Of are,and
R16140 T18877 T18876 arg2Of representative,are
R16141 T18877 T18878 arg1Of representative,of
R16142 T18881 T18879 arg1Of four,at
R16143 T18881 T18880 arg1Of four,least
R16144 T18883 T18878 arg2Of experiments,of
R16145 T18883 T18881 arg1Of experiments,four
R16146 T18883 T18882 arg1Of experiments,independent
R16147 T18886 T18884 arg2Of shown,and
R16148 T18886 T18885 arg2Of shown,are
R16149 T18886 T18887 arg1Of shown,as
R16150 T18888 T18887 arg2Of mean±SEM,as
R16151 T18889 T18890 arg1Of Results,were
R16152 T18889 T18891 arg2Of Results,analysed
R16153 T18891 T18890 arg2Of analysed,were
R16154 T18893 T18891 arg1Of ANOVA,analysed
R16155 T18893 T18892 arg2Of ANOVA,by
R16156 T18893 T18894 arg2Of ANOVA,followed
R16157 T18897 T18894 arg1Of test,followed
R16158 T18897 T18895 arg2Of test,by
R16159 T18897 T18896 arg1Of test,Newman-Keuls
R16458 T19292 T19291 arg1Of propionate,Fluticasone
R16459 T19292 T19293 arg1Of propionate,impairs
R16460 T19293 T19303 arg1Of impairs,vivo
R16461 T19293 T19306 arg1Of impairs,vivo
R16462 T19295 T19293 arg2Of interaction,impairs
R16463 T19295 T19294 arg1Of interaction,GATA-3
R16464 T19295 T19296 arg1Of interaction,with
R16465 T19297 T19298 arg1Of importin-α,and
R16466 T19298 T19296 arg2Of and,with
R16467 T19301 T19298 arg2Of localization,and
R16468 T19301 T19299 arg1Of localization,GATA-3
R16469 T19301 T19300 arg1Of localization,nuclear
R16470 T19303 T19302 arg1Of vivo,in
R16471 T19303 T19304 arg1Of vivo,and
R16472 T19306 T19304 arg2Of vivo,and
R16473 T19306 T19305 arg1Of vivo,ex
R16474 T19308 T19309 arg1Of A,and
R16475 T19309 T19307 arg2Of and,(
R16476 T19309 T19325 modOf and,demonstrated
R16477 T19310 T19309 arg2Of B,and
R16478 T19311 T19307 arg3Of ),(
R16479 T19313 T19312 arg1Of analysis,Co-immunoprecipitation
R16480 T19313 T19314 arg1Of analysis,of
R16481 T19313 T19325 arg1Of analysis,demonstrated
R16482 T19315 T19314 arg2Of PBMCs,of
R16483 T19315 T19316 arg1Of PBMCs,from
R16484 T19319 T19316 arg2Of patients,from
R16485 T19319 T19317 arg1Of patients,steroid-naïve
R16486 T19319 T19318 arg1Of patients,asthma
R16487 T19319 T19320 arg2Of patients,treated
R16488 T19319 T19324 arg1Of patients,vitro
R16489 T19320 T19321 arg1Of treated,with
R16490 T19322 T19321 arg2Of FP,with
R16491 T19324 T19323 arg1Of vitro,in
R16492 T19327 T19325 arg2Of interaction,demonstrated
R16493 T19327 T19326 arg1Of interaction,impaired
R16494 T19327 T19328 arg1Of interaction,between
R16495 T19329 T19330 arg1Of GATA-3,and
R16496 T19330 T19328 arg2Of and,between
R16497 T19330 T19332 arg2Of and,measured
R16498 T19331 T19330 arg2Of importin-α,and
R16499 T19332 T19333 arg1Of measured,at
R16500 T19335 T19333 arg2Of min,at
R16501 T19335 T19334 arg1Of min,60
R16502 T19337 T19336 arg1Of bar,Each
R16503 T19337 T19338 arg1Of bar,represents
R16504 T19338 T19347 arg1Of represents,;
R16505 T19340 T19338 arg2Of mean±SEM,represents
R16506 T19340 T19339 arg1Of mean±SEM,the
R16507 T19340 T19341 arg1Of mean±SEM,of
R16508 T19344 T19342 arg1Of three,at
R16509 T19344 T19343 arg1Of three,least
R16510 T19346 T19341 arg2Of experiments,of
R16511 T19346 T19344 arg1Of experiments,three
R16512 T19346 T19345 arg1Of experiments,independent
R16513 T19349 T19348 arg1Of p,***
R16514 T19349 T19351 arg1Of p,0.001
R16515 T19349 T19352 arg1Of p,compared
R16516 T19351 T19350 arg1Of 0.001,<
R16517 T19352 T19347 arg2Of compared,;
R16518 T19352 T19353 arg1Of compared,with
R16519 T19352 T19355 arg1Of compared,as
R16520 T19354 T19353 arg2Of control,with
R16521 T19356 T19355 arg2Of determined,as
R16522 T19356 T19357 arg1Of determined,by
R16523 T19359 T19357 arg2Of analysis.,by
R16524 T19359 T19358 arg1Of analysis.,ANOVA/Newman-Keuls
R16525 T19359 T19360 arg1Of analysis.,(
R16526 T19361 T19362 arg1Of C,and
R16527 T19362 T19360 arg2Of and,(
R16528 T19363 T19362 arg2Of D,and
R16529 T19364 T19360 arg3Of ),(
R16530 T19366 T19365 arg1Of analyses,Co-immunoprecipitation
R16531 T19366 T19367 arg1Of analyses,of
R16532 T19366 T19386 arg1Of analyses,demonstrated
R16533 T19368 T19367 arg2Of PBMCs,of
R16534 T19368 T19369 arg1Of PBMCs,from
R16535 T19372 T19369 arg2Of patients,from
R16536 T19372 T19370 arg1Of patients,steroid-naïve
R16537 T19372 T19371 arg1Of patients,asthma
R16538 T19372 T19373 arg2Of patients,treated
R16539 T19373 T19374 arg1Of treated,with
R16540 T19376 T19374 arg2Of FP,with
R16541 T19376 T19375 arg2Of FP,inhaled
R16542 T19376 T19377 arg1Of FP,(
R16543 T19376 T19385 arg1Of FP,vivo
R16544 T19379 T19377 arg2Of µg,(
R16545 T19379 T19378 arg1Of µg,500
R16546 T19379 T19380 arg1Of µg,via
R16547 T19382 T19380 arg2Of spacer,via
R16548 T19382 T19381 arg1Of spacer,a
R16549 T19383 T19377 arg3Of ),(
R16550 T19385 T19384 arg1Of vivo,in
R16551 T19386 T19347 arg3Of demonstrated,;
R16552 T19388 T19386 arg2Of association,demonstrated
R16553 T19388 T19387 arg2Of association,decreased
R16554 T19388 T19389 arg1Of association,between
R16555 T19390 T19391 arg1Of GATA-3,and
R16556 T19391 T19389 arg2Of and,between
R16557 T19392 T19391 arg2Of importin-α,and
R16558 T19395 T19393 arg1Of values,The
R16559 T19395 T19394 arg1Of values,individual
R16560 T19395 T19396 arg1Of values,for
R16561 T19395 T19399 arg1Of values,are
R16562 T19395 T19400 arg2Of values,presented
R16563 T19398 T19396 arg2Of treatment,for
R16564 T19398 T19397 arg1Of treatment,each
R16565 T19400 T19399 arg2Of presented,are
R16566 T19403 T19402 arg2Of E,(
R16567 T19404 T19402 arg3Of ),(
R16568 T19407 T19400 arg3Of blot,presented
R16569 T19407 T19401 arg1Of blot,graphically.
R16570 T19407 T19402 arg1Of blot,(
R16571 T19407 T19405 arg1Of blot,Representative
R16572 T19407 T19406 arg1Of blot,Western
R16573 T19407 T19408 arg1Of blot,showing
R16574 T19411 T19410 arg1Of expression,importin-α
R16575 T19411 T19412 arg1Of expression,was
R16576 T19411 T19413 arg2Of expression,unaffected
R16577 T19413 T19408 arg2Of unaffected,showing
R16578 T19413 T19409 arg1Of unaffected,that
R16579 T19413 T19412 arg2Of unaffected,was
R16580 T19415 T19413 arg1Of inhalation,unaffected
R16581 T19415 T19414 arg2Of inhalation,by
R16582 T19415 T19416 arg1Of inhalation,of
R16583 T19417 T19416 arg2Of FP,of
R16584 T19418 T19419 arg1Of Blot,is
R16585 T19418 T19420 arg1Of Blot,representative
R16586 T19420 T19419 arg2Of representative,is
R16587 T19420 T19421 arg1Of representative,of
R16588 T19422 T19421 arg2Of gels,of
R16589 T19422 T19423 arg1Of gels,from
R16590 T19425 T19423 arg2Of participants,from
R16591 T19425 T19424 arg1Of participants,three
R16836 T19734 T19732 arg2Of propionate,Inhaled
R16837 T19734 T19733 arg1Of propionate,fluticasone
R16838 T19734 T19735 arg1Of propionate,impairs
R16839 T19738 T19735 arg2Of localization,impairs
R16840 T19738 T19736 arg1Of localization,GATA-3
R16841 T19738 T19737 arg1Of localization,nuclear
R16842 T19738 T19739 arg1Of localization,in
R16843 T19740 T19739 arg2Of PBMCs,in
R16844 T19742 T19741 arg2Of A,(
R16845 T19743 T19741 arg3Of ),(
R16846 T19745 T19741 arg1Of immunocytochemistry,(
R16847 T19745 T19744 arg1Of immunocytochemistry,Representative
R16848 T19745 T19746 arg1Of immunocytochemistry,of
R16849 T19747 T19746 arg2Of showing,of
R16850 T19747 T19778 arg1Of showing,following
R16851 T19749 T19747 arg2Of effect,showing
R16852 T19749 T19748 arg1Of effect,the
R16853 T19749 T19750 arg1Of effect,of
R16854 T19749 T19757 arg1Of effect,on
R16855 T19752 T19750 arg2Of FP,of
R16856 T19752 T19751 arg2Of FP,inhaled
R16857 T19752 T19753 arg1Of FP,(
R16858 T19755 T19753 arg2Of µg,(
R16859 T19755 T19754 arg1Of µg,500
R16860 T19756 T19753 arg3Of ),(
R16861 T19758 T19759 arg1Of GR,and
R16862 T19760 T19759 arg2Of GATA-3,and
R16863 T19764 T19763 arg2Of B,(
R16864 T19765 T19763 arg3Of ),(
R16865 T19768 T19757 arg2Of immunoreactivity,on
R16866 T19768 T19758 arg1Of immunoreactivity,GR
R16867 T19768 T19760 arg1Of immunoreactivity,GATA-3
R16868 T19768 T19761 arg1Of immunoreactivity,nuclear
R16869 T19768 T19762 arg1Of immunoreactivity,localisation.
R16870 T19768 T19763 arg1Of immunoreactivity,(
R16871 T19768 T19766 arg1Of immunoreactivity,Nuclear
R16872 T19768 T19767 arg1Of immunoreactivity,GATA-3
R16873 T19768 T19769 arg1Of immunoreactivity,in
R16874 T19768 T19771 arg1Of immunoreactivity,from
R16875 T19770 T19769 arg2Of PBMCs,in
R16876 T19775 T19771 arg2Of patients,from
R16877 T19775 T19772 arg1Of patients,seven
R16878 T19775 T19773 arg1Of patients,steroid-naïve
R16879 T19775 T19774 arg1Of patients,asthma
R16880 T19777 T19776 arg1Of h,2
R16881 T19778 T19777 arg1Of following,h
R16882 T19781 T19778 arg2Of treatment,following
R16883 T19781 T19779 arg2Of treatment,inhaled
R16884 T19781 T19780 arg1Of treatment,FP
R16885 T19781 T19782 arg1Of treatment,(
R16886 T19783 T19784 arg1Of 100,or
R16887 T19785 T19784 arg2Of 500,or
R16888 T19786 T19782 arg2Of µg,(
R16889 T19786 T19783 arg1Of µg,100
R16890 T19786 T19785 arg1Of µg,500
R16891 T19786 T19787 arg1Of µg,via
R16892 T19788 T19787 arg2Of spacer,via
R16893 T19789 T19782 arg3Of ),(
R16894 T19791 T19792 arg1Of median,and
R16895 T19793 T19792 arg2Of interquartile,and
R16896 T19794 T19790 arg1Of ranges,The
R16897 T19794 T19791 arg1Of ranges,median
R16898 T19794 T19793 arg1Of ranges,interquartile
R16899 T19794 T19795 arg1Of ranges,for
R16900 T19794 T19798 arg1Of ranges,are
R16901 T19794 T19799 arg2Of ranges,presented
R16902 T19797 T19795 arg2Of treatment,for
R16903 T19797 T19796 arg1Of treatment,each
R16904 T19799 T19798 arg2Of presented,are
R16905 T19799 T19800 arg1Of presented,as
R16906 T19799 T19807 arg1Of presented,;
R16907 T19803 T19800 arg2Of plot,as
R16908 T19803 T19801 arg1Of plot,a
R16909 T19803 T19802 arg1Of plot,box-and-whiskers
R16910 T19803 T19804 arg1Of plot,(
R16911 T19805 T19804 arg2Of n = 7,(
R16912 T19806 T19804 arg3Of ),(
R16913 T19811 T19810 arg1Of 0.05,<
R16914 T19812 T19808 arg1Of Wilcoxon,*
R16915 T19812 T19809 arg1Of Wilcoxon,p
R16916 T19812 T19811 arg1Of Wilcoxon,0.05
R16917 T19812 T19813 arg2Of Wilcoxon,'s
R16918 T19815 T19813 arg1Of test,'s
R16919 T19815 T19814 arg1Of test,rank
R16920 T19815 T19816 arg1Of test,compared
R16921 T19815 T19826 arg1Of test,demonstrated
R16922 T19817 T19816 arg2Of with,compared
R16923 T19820 T19819 arg2Of C,(
R16924 T19821 T19819 arg3Of ),(
R16925 T19823 T19817 arg2Of analyses,with
R16926 T19823 T19818 arg1Of analyses,placebo.
R16927 T19823 T19819 arg1Of analyses,(
R16928 T19823 T19822 arg1Of analyses,Immunoblotting
R16929 T19823 T19824 arg1Of analyses,of
R16930 T19825 T19824 arg2Of PBMCs,of
R16931 T19826 T19836 arg1Of demonstrated,and
R16932 T19829 T19826 arg2Of decrease,demonstrated
R16933 T19829 T19827 arg1Of decrease,a
R16934 T19829 T19828 arg1Of decrease,time-dependent
R16935 T19829 T19830 arg1Of decrease,in
R16936 T19832 T19830 arg2Of expression,in
R16937 T19832 T19831 arg1Of expression,nuclear
R16938 T19832 T19833 arg1Of expression,of
R16939 T19834 T19833 arg2Of GATA-3,of
R16940 T19836 T19807 arg2Of and,;
R16941 T19836 T19835 arg1Of and,","
R16942 T19840 T19837 arg2Of expression,increased
R16943 T19840 T19838 arg1Of expression,cytoplasmic
R16944 T19840 T19839 arg1Of expression,GATA-3
R16945 T19840 T19841 arg1Of expression,after
R16946 T19840 T19852 arg1Of expression,demonstrated
R16947 T19840 T19863 arg1Of expression,increased
R16948 T19842 T19841 arg2Of inhalation,after
R16949 T19842 T19843 arg1Of inhalation,of
R16950 T19846 T19845 arg2Of D,(
R16951 T19847 T19845 arg3Of ),(
R16952 T19849 T19843 arg2Of analyses,of
R16953 T19849 T19844 arg1Of analyses,FP.
R16954 T19849 T19845 arg1Of analyses,(
R16955 T19849 T19848 arg1Of analyses,Immunoblotting
R16956 T19849 T19850 arg1Of analyses,of
R16957 T19851 T19850 arg2Of PBMCs,of
R16958 T19852 T19862 arg1Of demonstrated,and
R16959 T19855 T19852 arg2Of decrease,demonstrated
R16960 T19855 T19853 arg1Of decrease,a
R16961 T19855 T19854 arg1Of decrease,dose-dependent
R16962 T19855 T19856 arg1Of decrease,in
R16963 T19858 T19856 arg2Of expression,in
R16964 T19858 T19857 arg1Of expression,nuclear
R16965 T19858 T19859 arg1Of expression,of
R16966 T19860 T19859 arg2Of GATA-3,of
R16967 T19862 T19836 arg2Of and,and
R16968 T19862 T19861 arg1Of and,","
R16969 T19863 T19862 arg2Of increased,and
R16970 T19863 T19869 arg1Of increased,after
R16971 T19866 T19863 arg2Of expression,increased
R16972 T19866 T19864 arg1Of expression,cytoplasmic
R16973 T19866 T19865 arg1Of expression,GATA-3
R16974 T19868 T19867 arg1Of h,2
R16975 T19869 T19868 arg1Of after,h
R16976 T19870 T19869 arg2Of inhalation,after
R16977 T19870 T19871 arg1Of inhalation,of
R16978 T19872 T19871 arg2Of FP,of
R16979 T19874 T19873 arg1Of H1,Histone
R16980 T19874 T19875 arg1Of H1,and
R16981 T19875 T19878 arg1Of and,confirmed
R16982 T19877 T19875 arg2Of immunoblotting,and
R16983 T19877 T19876 arg1Of immunoblotting,MEK-1
R16984 T19881 T19878 arg2Of protein,confirmed
R16985 T19881 T19879 arg1Of protein,equivalent
R16986 T19881 T19880 arg1Of protein,total
R16987 T19881 T19882 arg1Of protein,loading
R16988 T19882 T19883 arg1Of loading,for
R16989 T19882 T19889 arg1Of loading,respectively
R16990 T19885 T19886 arg1Of nuclear,and
R16991 T19887 T19886 arg2Of cytoplasmic,and
R16992 T19888 T19883 arg2Of fractions,for
R16993 T19888 T19884 arg1Of fractions,the
R16994 T19888 T19885 arg1Of fractions,nuclear
R16995 T19888 T19887 arg1Of fractions,cytoplasmic
R16996 T19890 T19891 arg1Of Quantification,of
R16997 T19890 T19903 arg1Of Quantification,is
R16998 T19890 T19904 arg2Of Quantification,shown
R16999 T19894 T19891 arg2Of data,of
R17000 T19894 T19892 arg1Of data,the
R17001 T19894 T19893 arg1Of data,densitometry
R17002 T19894 T19895 arg1Of data,in
R17003 T19897 T19896 arg2Of C,(
R17004 T19897 T19899 arg1Of C,and
R17005 T19898 T19896 arg3Of ),(
R17006 T19899 T19895 arg2Of and,in
R17007 T19901 T19899 arg2Of D,and
R17008 T19901 T19900 arg2Of D,(
R17009 T19902 T19900 arg3Of ),(
R17010 T19904 T19903 arg2Of shown,is
R17011 T19904 T19905 arg1Of shown,as
R17012 T19908 T19905 arg2Of plot,as
R17013 T19908 T19906 arg1Of plot,a
R17014 T19908 T19907 arg1Of plot,box-and-whiskers
R17015 T19908 T19909 arg1Of plot,of
R17016 T19910 T19909 arg2Of results,of
R17017 T19910 T19911 arg1Of results,from
R17018 T19910 T19914 arg2Of results,for
R17019 T19910 T19915 arg1Of results,which
R17020 T19913 T19911 arg2Of participants,from
R17021 T19913 T19912 arg1Of participants,n = 6
R17022 T19916 T19917 arg1Of data,were
R17023 T19917 T19914 arg1Of were,for
R17024 T19919 T19920 arg1Of *p,<
R17025 T19921 T19917 arg2Of 0.05,were
R17026 T19921 T19918 arg1Of 0.05,available.
R17027 T19921 T19919 arg1Of 0.05,*p
R17028 T19921 T19922 arg2Of 0.05,compared
R17029 T19921 T19933 modOf 0.05,demonstrated
R17030 T19921 T19945 arg1Of 0.05,of
R17031 T19924 T19922 arg3Of control.,compared
R17032 T19924 T19923 arg1Of control.,to
R17033 T19924 T19925 arg1Of control.,(
R17034 T19926 T19925 arg2Of E,(
R17035 T19927 T19925 arg3Of ),(
R17036 T19930 T19928 arg1Of analyses,Western
R17037 T19930 T19929 arg1Of analyses,blot
R17038 T19930 T19931 arg1Of analyses,of
R17039 T19930 T19933 arg1Of analyses,demonstrated
R17040 T19932 T19931 arg2Of PBMCs,of
R17041 T19936 T19933 arg2Of decrease,demonstrated
R17042 T19936 T19934 arg1Of decrease,a
R17043 T19936 T19935 arg1Of decrease,time-dependent
R17044 T19936 T19937 arg1Of decrease,in
R17045 T19939 T19937 arg2Of phosphorylation,in
R17046 T19939 T19938 arg1Of phosphorylation,dual
R17047 T19939 T19940 arg1Of phosphorylation,(
R17048 T19941 T19942 arg1Of threonine-180,and
R17049 T19942 T19940 arg2Of and,(
R17050 T19943 T19942 arg2Of tyrosine-182,and
R17051 T19944 T19940 arg3Of ),(
R17052 T19947 T19945 arg2Of MAPK,of
R17053 T19947 T19946 arg1Of MAPK,p38
R17054 T19947 T19948 arg1Of MAPK,after
R17055 T19949 T19948 arg2Of inhalation,after
R17056 T19949 T19950 arg1Of inhalation,of
R17057 T19951 T19950 arg2Of FP,of
R17058 T19951 T19952 arg1Of FP,(
R17059 T19954 T19952 arg2Of µg,(
R17060 T19954 T19953 arg1Of µg,500
R17061 T19955 T19952 arg3Of ),(
R17062 T19957 T19956 arg1Of results,The
R17063 T19957 T19958 arg2Of results,shown
R17064 T19957 T19963 arg1Of results,are
R17065 T19957 T19964 arg1Of results,representative
R17066 T19958 T19959 arg1Of shown,in
R17067 T19961 T19959 arg2Of E,in
R17068 T19961 T19960 arg2Of E,(
R17069 T19962 T19960 arg3Of ),(
R17070 T19964 T19963 arg2Of representative,are
R17071 T19964 T19965 arg1Of representative,of
R17072 T19966 T19965 arg2Of samples,of
R17073 T19966 T19967 arg1Of samples,from
R17074 T19969 T19967 arg2Of participants,from
R17075 T19969 T19968 arg1Of participants,two

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T8451 9-12 DT denotes The
T8452 13-19 NN denotes Effect
T8453 20-22 IN denotes of
T8454 23-38 NNS denotes Corticosteroids
T8455 39-41 IN denotes on
T8456 42-48 NNP denotes GATA-3
T8457 49-56 NNP denotes Nuclear
T8458 57-70 NNP denotes Translocation
T8459 71-74 CC denotes and
T8460 75-79 NN denotes IL-4
T8461 80-84 NNP denotes mRNA
T8462 85-100 NNP denotes Corticosteroids
T8463 101-104 VBP denotes are
T8464 105-114 JJ denotes effective
T8465 115-117 IN denotes in
T8466 118-128 VBG denotes inhibiting
T8467 129-145 JJ denotes GATA-3-regulated
T8468 146-150 NN denotes IL-4
T8469 151-155 NN denotes gene
T8470 156-166 NN denotes expression
T8471 167-169 IN denotes in
T8472 170-175 NN denotes vitro
T8473 176-179 CC denotes and
T8474 180-182 IN denotes in
T8475 183-187 NN denotes vivo
T8476 188-189 NNP denotes [
T8477 189-191 CD denotes 32
T8478 191-192 NNP denotes ]
T8479 192-193 . denotes .
T8480 194-196 PRP denotes We
T8481 197-206 RB denotes therefore
T8482 207-219 VBD denotes investigated
T8483 220-227 IN denotes whether
T8484 228-243 NNS denotes corticosteroids
T8485 244-250 VBP denotes affect
T8486 251-259 JJ denotes anti-CD3
T8487 259-260 NN denotes /
T8488 260-264 CD denotes CD28
T8489 265-275 VBD denotes stimulated
T8490 276-283 JJ denotes nuclear
T8491 284-290 NN denotes import
T8492 291-293 IN denotes of
T8493 294-300 NN denotes GATA-3
T8494 300-301 . denotes .
T8495 302-313 NN denotes Stimulation
T8496 314-316 IN denotes of
T8497 317-322 NNS denotes cells
T8498 323-327 IN denotes with
T8499 328-336 JJ denotes anti-CD3
T8500 336-337 NN denotes /
T8501 337-341 CD denotes CD28
T8502 342-350 VBD denotes resulted
T8503 351-353 IN denotes in
T8504 354-355 DT denotes a
T8505 356-361 JJ denotes rapid
T8506 362-381 NN denotes cytoplasmic/nuclear
T8507 382-388 NN denotes GATA-3
T8508 389-402 NN denotes translocation
T8509 403-404 -LRB- denotes (
T8510 404-410 NN denotes Figure
T8511 411-413 CD denotes 1A
T8512 413-414 -RRB- denotes )
T8513 414-415 , denotes ,
T8514 416-426 VBG denotes confirming
T8515 427-430 PRP$ denotes our
T8516 431-439 JJ denotes previous
T8517 440-447 NNS denotes results
T8518 448-449 NNP denotes [
T8519 449-451 CD denotes 12
T8520 451-452 NNP denotes ]
T8521 452-453 . denotes .
T8522 454-456 PRP denotes We
T8523 457-461 RB denotes also
T8524 462-471 VBD denotes confirmed
T8525 472-473 DT denotes a
T8526 474-479 JJ denotes clear
T8527 480-490 NN denotes separation
T8528 491-493 IN denotes of
T8529 494-501 JJ denotes nuclear
T8530 502-505 CC denotes and
T8531 506-515 JJ denotes cytosolic
T8532 516-525 NNS denotes fractions
T8533 526-528 IN denotes as
T8534 529-538 VBN denotes indicated
T8535 539-541 IN denotes by
T8536 542-549 NN denotes histone
T8537 550-552 CD denotes H1
T8538 553-556 CC denotes and
T8539 557-562 CD denotes MEK-1
T8540 563-570 NNS denotes markers
T8541 571-572 -LRB- denotes (
T8542 572-578 NN denotes Figure
T8543 579-581 NN denotes 1B
T8544 581-582 -RRB- denotes )
T8545 582-583 . denotes .
T8546 584-587 DT denotes The
T8547 588-594 JJ denotes potent
T8548 595-602 JJ denotes topical
T8549 603-617 JJ denotes corticosteroid
T8550 618-620 NN denotes FP
T8551 621-627 VBD denotes caused
T8552 628-637 JJ denotes sustained
T8553 638-642 NN denotes loss
T8554 643-645 IN denotes of
T8555 646-653 JJ denotes nuclear
T8556 654-660 JJ denotes GATA-3
T8557 661-671 NN denotes expression
T8558 672-675 CC denotes and
T8559 676-687 JJ denotes cytoplasmic
T8560 688-697 NN denotes retention
T8561 698-700 IN denotes of
T8562 701-707 NN denotes GATA-3
T8563 708-710 IN denotes at
T8564 711-725 NNS denotes concentrations
T8565 726-733 VBG denotes ranging
T8566 734-738 IN denotes from
T8567 739-741 CD denotes 10
T8568 741-742 CD denotes −
T8569 742-744 CD denotes 12
T8570 745-747 TO denotes to
T8571 748-750 CD denotes 10
T8572 750-751 CD denotes −
T8573 751-752 CD denotes 8
T8574 753-754 NNP denotes M
T8575 754-755 , denotes ,
T8576 756-761 WDT denotes which
T8577 762-767 VBP denotes cover
T8578 768-771 DT denotes the
T8579 772-783 JJ denotes therapeutic
T8580 784-789 NN denotes range
T8581 790-791 NNP denotes [
T8582 791-793 CD denotes 37
T8583 793-794 NNP denotes ]
T8584 794-795 . denotes .
T8585 796-800 DT denotes This
T8586 801-807 NN denotes effect
T8587 808-811 VBD denotes was
T8588 812-825 NN denotes concentration
T8589 825-826 : denotes -
T8590 827-830 CC denotes and
T8591 831-845 JJ denotes time-dependent
T8592 845-846 , denotes ,
T8593 847-851 IN denotes with
T8594 852-853 DT denotes a
T8595 854-858 JJ denotes peak
T8596 859-865 NN denotes effect
T8597 866-868 IN denotes of
T8598 869-878 JJ denotes 11.6-fold
T8599 879-881 IN denotes at
T8600 882-884 CD denotes 30
T8601 885-888 NN denotes min
T8602 889-891 IN denotes at
T8603 892-893 DT denotes a
T8604 894-907 NN denotes concentration
T8605 908-910 IN denotes of
T8606 911-913 CD denotes 10
T8607 913-914 NN denotes −
T8608 914-915 CD denotes 8
T8609 916-917 NNP denotes M
T8610 918-919 -LRB- denotes (
T8611 919-925 NNP denotes Figure
T8612 926-928 NNP denotes 1C
T8613 928-929 -RRB- denotes )
T8614 930-933 CC denotes and
T8615 934-937 VBD denotes was
T8616 938-948 VBN denotes associated
T8617 949-953 IN denotes with
T8618 954-960 JJ denotes marked
T8619 961-971 NNS denotes reductions
T8620 972-974 IN denotes in
T8621 975-983 JJ denotes anti-CD3
T8622 983-984 NN denotes /
T8623 984-988 CD denotes CD28
T8624 989-999 VBD denotes stimulated
T8625 1000-1004 NN denotes IL-4
T8626 1005-1008 CC denotes and
T8627 1009-1013 NN denotes IL-5
T8628 1014-1018 NNP denotes mRNA
T8629 1019-1029 NN denotes expression
T8630 1030-1031 -LRB- denotes (
T8631 1031-1037 NN denotes Figure
T8632 1038-1040 CD denotes 1D
T8633 1040-1041 -RRB- denotes )
T8634 1042-1045 CC denotes and
T8635 1046-1047 DT denotes a
T8636 1048-1052 NN denotes loss
T8637 1053-1055 IN denotes of
T8638 1056-1062 JJ denotes GATA-3
T8639 1063-1070 JJ denotes binding
T8640 1071-1073 TO denotes to
T8641 1074-1077 DT denotes the
T8642 1078-1084 JJ denotes native
T8643 1085-1089 NN denotes IL-5
T8644 1090-1098 NN denotes promoter
T8645 1099-1100 -LRB- denotes (
T8646 1100-1106 NN denotes Figure
T8647 1107-1109 CD denotes 1E
T8648 1109-1110 -RRB- denotes )
T8649 1110-1111 . denotes .
T9109 2661-2677 NNP denotes Ligand-Activated
T9110 2678-2680 NNP denotes GR
T9111 2681-2689 VBZ denotes Competes
T9112 2690-2694 IN denotes with
T9113 2695-2701 NNP denotes GATA-3
T9114 2702-2705 IN denotes for
T9115 2706-2716 NNP denotes Importin-α
T9116 2717-2719 PRP denotes We
T9117 2720-2729 VBD denotes confirmed
T9118 2730-2733 CC denotes and
T9119 2734-2742 VBD denotes extended
T9120 2743-2751 JJ denotes previous
T9121 2752-2756 NNS denotes data
T9122 2757-2758 NNP denotes [
T9123 2758-2760 CD denotes 20
T9124 2760-2761 NNP denotes ]
T9125 2762-2764 TO denotes to
T9126 2765-2769 VB denotes show
T9127 2770-2774 IN denotes that
T9128 2775-2791 JJ denotes ligand-activated
T9129 2792-2794 NNP denotes GR
T9130 2795-2797 RB denotes as
T9131 2798-2802 RB denotes well
T9132 2803-2805 IN denotes as
T9133 2806-2812 JJ denotes GATA-3
T9134 2813-2817 NNS denotes uses
T9135 2818-2828 JJ denotes importin-α
T9136 2829-2832 IN denotes for
T9137 2833-2836 PRP$ denotes its
T9138 2837-2844 JJ denotes nuclear
T9139 2845-2851 NN denotes import
T9140 2852-2853 -LRB- denotes (
T9141 2853-2859 NN denotes Figure
T9142 2860-2862 CD denotes 2A
T9143 2863-2866 CC denotes and
T9144 2867-2869 CD denotes 2B
T9145 2869-2870 -RRB- denotes )
T9146 2870-2871 . denotes .
T9147 2872-2876 DT denotes This
T9148 2877-2888 NN denotes interaction
T9149 2889-2896 IN denotes between
T9150 2897-2899 NNP denotes GR
T9151 2900-2903 CC denotes and
T9152 2904-2914 NNP denotes importin-α
T9153 2915-2918 VBD denotes was
T9154 2919-2930 JJ denotes significant
T9155 2931-2933 IN denotes at
T9156 2934-2948 NNS denotes concentrations
T9157 2949-2951 RB denotes as
T9158 2952-2955 JJ denotes low
T9159 2956-2958 IN denotes as
T9160 2959-2961 CD denotes 10
T9161 2961-2962 CD denotes −
T9162 2962-2964 CD denotes 12
T9163 2965-2966 NNP denotes M
T9164 2967-2970 CC denotes and
T9165 2971-2974 VBD denotes was
T9166 2975-2982 JJ denotes maximal
T9167 2983-2987 IN denotes with
T9168 2988-2990 CD denotes 10
T9169 2990-2991 NN denotes −
T9170 2991-2992 CD denotes 8
T9171 2993-2994 NNP denotes M
T9172 2995-2997 NNP denotes FP
T9173 2997-2998 . denotes .
T9174 2999-3009 JJ denotes Subsequent
T9175 3010-3012 NNP denotes GR
T9176 3013-3020 JJ denotes nuclear
T9177 3021-3034 NN denotes translocation
T9178 3035-3038 VBD denotes was
T9179 3039-3044 JJ denotes rapid
T9180 3045-3048 CC denotes and
T9181 3049-3058 VBD denotes sustained
T9182 3059-3061 IN denotes at
T9183 3062-3073 JJ denotes significant
T9184 3074-3080 NNS denotes levels
T9185 3081-3084 IN denotes for
T9186 3085-3087 IN denotes at
T9187 3088-3093 JJS denotes least
T9188 3094-3096 CD denotes 14
T9189 3097-3098 NN denotes h
T9190 3099-3100 -LRB- denotes (
T9191 3100-3106 NN denotes Figure
T9192 3107-3109 NN denotes 2B
T9193 3109-3110 -RRB- denotes )
T9194 3110-3111 . denotes .
T9195 3112-3117 VBG denotes Using
T9196 3118-3128 JJ denotes IP-Western
T9197 3129-3137 VBG denotes blotting
T9198 3138-3140 PRP denotes we
T9199 3141-3147 VBD denotes showed
T9200 3148-3152 IN denotes that
T9201 3153-3155 NNP denotes FP
T9202 3156-3158 IN denotes at
T9203 3159-3161 CD denotes 10
T9204 3161-3162 CD denotes −
T9205 3162-3164 CD denotes 12
T9206 3165-3167 CD denotes 10
T9207 3167-3168 NN denotes −
T9208 3168-3169 CD denotes 8
T9209 3170-3171 NNP denotes M
T9210 3172-3181 VBD denotes decreased
T9211 3182-3185 DT denotes the
T9212 3186-3197 NN denotes association
T9213 3198-3205 IN denotes between
T9214 3206-3212 NNP denotes GATA-3
T9215 3213-3216 CC denotes and
T9216 3217-3227 JJ denotes importin-α
T9217 3228-3235 VBN denotes induced
T9218 3236-3238 IN denotes by
T9219 3239-3247 JJ denotes anti-CD3
T9220 3247-3248 NN denotes /
T9221 3248-3252 CD denotes CD28
T9222 3253-3264 NN denotes stimulation
T9223 3265-3267 IN denotes in
T9224 3268-3269 DT denotes a
T9225 3270-3293 JJ denotes concentration-dependent
T9226 3294-3300 NN denotes manner
T9227 3301-3302 -LRB- denotes (
T9228 3302-3308 NN denotes Figure
T9229 3309-3311 CD denotes 2C
T9230 3311-3312 -RRB- denotes )
T9231 3312-3313 . denotes .
T9232 3314-3316 IN denotes In
T9233 3317-3325 NN denotes addition
T9234 3325-3326 , denotes ,
T9235 3327-3332 VBG denotes using
T9236 3333-3345 JJ denotes GFP-labelled
T9237 3346-3352 NN denotes GATA-3
T9238 3353-3356 CC denotes and
T9239 3357-3365 JJ denotes confocal
T9240 3366-3376 NN denotes microscopy
T9241 3377-3379 PRP denotes we
T9242 3380-3392 VBD denotes demonstrated
T9243 3393-3397 IN denotes that
T9244 3398-3404 JJ denotes GATA-3
T9245 3405-3412 JJ denotes nuclear
T9246 3413-3419 NN denotes import
T9247 3420-3429 VBG denotes following
T9248 3430-3438 JJ denotes anti-CD3
T9249 3438-3439 NN denotes /
T9250 3439-3443 CD denotes CD28
T9251 3444-3455 NN denotes stimulation
T9252 3456-3459 IN denotes for
T9253 3460-3462 CD denotes 30
T9254 3463-3466 NN denotes min
T9255 3467-3470 VBD denotes was
T9256 3471-3481 VBN denotes attenuated
T9257 3482-3484 IN denotes by
T9258 3485-3497 NN denotes pretreatment
T9259 3498-3502 IN denotes with
T9260 3503-3505 NNP denotes FP
T9261 3506-3507 -LRB- denotes (
T9262 3507-3509 CD denotes 10
T9263 3509-3510 NN denotes −
T9264 3510-3511 CD denotes 8
T9265 3512-3513 NNP denotes M
T9266 3513-3514 -RRB- denotes )
T9267 3515-3516 -LRB- denotes (
T9268 3516-3522 NN denotes Figure
T9269 3523-3525 CD denotes 2D
T9270 3525-3526 -RRB- denotes )
T9271 3526-3527 . denotes .
T10194 5088-5094 NN denotes Effect
T10195 5095-5097 IN denotes on
T10196 5098-5103 NNP denotes MKP-1
T10197 5104-5117 NNP denotes Dexamethasone
T10198 5118-5126 VBZ denotes inhibits
T10199 5127-5130 CD denotes p38
T10200 5131-5135 NNP denotes MAPK
T10201 5136-5144 NN denotes function
T10202 5145-5147 IN denotes in
T10203 5148-5149 DT denotes a
T10204 5150-5154 NN denotes cell
T10205 5155-5159 NN denotes type
T10206 5160-5168 JJ denotes specific
T10207 5169-5175 NN denotes manner
T10208 5176-5183 IN denotes through
T10209 5184-5187 DT denotes the
T10210 5188-5193 JJ denotes rapid
T10211 5194-5203 NN denotes induction
T10212 5204-5206 IN denotes of
T10213 5207-5210 DT denotes the
T10214 5211-5215 JJ denotes dual
T10215 5216-5222 NN denotes kinase
T10216 5223-5234 NN denotes phosphatase
T10217 5235-5240 NNP denotes MKP-1
T10218 5241-5242 -LRB- denotes (
T10219 5242-5246 NNP denotes MAPK
T10220 5247-5260 JJ denotes phosphatase-1
T10221 5260-5261 -RRB- denotes )
T10222 5261-5262 , denotes ,
T10223 5263-5266 CC denotes and
T10224 5267-5271 DT denotes this
T10225 5272-5278 NN denotes effect
T10226 5279-5284 VBZ denotes lasts
T10227 5285-5288 IN denotes for
T10228 5289-5291 RB denotes up
T10229 5292-5294 TO denotes to
T10230 5295-5297 CD denotes 24
T10231 5298-5299 NN denotes h
T10232 5300-5301 NNP denotes [
T10233 5301-5303 CD denotes 28
T10234 5303-5304 NNP denotes ]
T10235 5304-5305 . denotes .
T10236 5306-5308 NNP denotes FP
T10237 5309-5310 -LRB- denotes (
T10238 5310-5312 CD denotes 10
T10239 5312-5313 NN denotes −
T10240 5313-5314 CD denotes 8
T10241 5315-5316 NNP denotes M
T10242 5316-5317 -RRB- denotes )
T10243 5318-5327 NN denotes treatment
T10244 5328-5330 IN denotes of
T10245 5331-5337 JJ denotes HuT-78
T10246 5338-5343 NNS denotes cells
T10247 5344-5353 VBN denotes activated
T10248 5354-5356 IN denotes by
T10249 5357-5365 JJ denotes anti-CD3
T10250 5365-5366 NN denotes /
T10251 5366-5370 CD denotes CD28
T10252 5371-5373 IN denotes in
T10253 5374-5379 NN denotes vitro
T10254 5380-5393 RB denotes significantly
T10255 5394-5403 VBD denotes decreased
T10256 5404-5407 CD denotes p38
T10257 5408-5412 NNP denotes MAPK
T10258 5413-5428 NN denotes phosphorylation
T10259 5429-5430 -LRB- denotes (
T10260 5430-5436 NN denotes Figure
T10261 5437-5439 NN denotes 3A
T10262 5439-5440 -RRB- denotes )
T10263 5441-5444 CC denotes and
T10264 5445-5453 NN denotes activity
T10265 5454-5462 VBN denotes measured
T10266 5463-5465 IN denotes by
T10267 5466-5481 NN denotes phosphorylation
T10268 5482-5484 IN denotes of
T10269 5485-5488 DT denotes the
T10270 5489-5499 JJ denotes downstream
T10271 5500-5506 NN denotes target
T10272 5507-5512 NNP denotes ATF-2
T10273 5513-5514 -LRB- denotes (
T10274 5514-5520 NNP denotes Figure
T10275 5521-5523 NNP denotes 3B
T10276 5523-5524 -RRB- denotes )
T10277 5524-5525 . denotes .
T10278 5526-5530 DT denotes This
T10279 5531-5537 NN denotes effect
T10280 5538-5541 VBD denotes was
T10281 5542-5550 VBN denotes detected
T10282 5551-5553 IN denotes at
T10283 5554-5556 CD denotes 30
T10284 5557-5560 NN denotes min
T10285 5561-5564 CC denotes and
T10286 5565-5571 VBD denotes lasted
T10287 5572-5575 IN denotes for
T10288 5576-5578 IN denotes at
T10289 5579-5584 JJS denotes least
T10290 5585-5587 CD denotes 14
T10291 5588-5589 NN denotes h
T10292 5590-5591 -LRB- denotes (
T10293 5591-5597 NN denotes Figure
T10294 5598-5600 NN denotes 3B
T10295 5600-5601 -RRB- denotes )
T10296 5601-5602 . denotes .
T10297 5603-5605 NNP denotes FP
T10298 5606-5607 -LRB- denotes (
T10299 5607-5609 CD denotes 10
T10300 5609-5610 NN denotes −
T10301 5610-5611 CD denotes 8
T10302 5612-5613 NNP denotes M
T10303 5613-5614 -RRB- denotes )
T10304 5615-5619 RB denotes also
T10305 5620-5633 RB denotes significantly
T10306 5634-5641 VBN denotes reduced
T10307 5642-5648 JJ denotes GATA-3
T10308 5649-5655 NN denotes serine
T10309 5656-5671 NN denotes phosphorylation
T10310 5672-5679 VBN denotes induced
T10311 5680-5682 IN denotes by
T10312 5683-5691 JJ denotes anti-CD3
T10313 5691-5692 NN denotes /
T10314 5692-5696 CD denotes CD28
T10315 5697-5708 NN denotes stimulation
T10316 5709-5711 IN denotes in
T10317 5712-5716 DT denotes both
T10318 5717-5718 DT denotes a
T10319 5719-5723 NN denotes time
T10320 5723-5724 : denotes -
T10321 5725-5728 CC denotes and
T10322 5729-5752 JJ denotes concentration-dependent
T10323 5753-5759 NN denotes manner
T10324 5760-5761 -LRB- denotes (
T10325 5761-5767 NN denotes Figure
T10326 5768-5770 NN denotes 3C
T10327 5770-5771 -RRB- denotes )
T10328 5771-5772 . denotes .
T10329 5773-5777 DT denotes This
T10330 5778-5787 NN denotes reduction
T10331 5788-5790 IN denotes in
T10332 5791-5797 JJ denotes GATA-3
T10333 5798-5813 NN denotes phosphorylation
T10334 5814-5817 VBD denotes was
T10335 5818-5822 RB denotes also
T10336 5823-5827 VBN denotes seen
T10337 5828-5832 IN denotes with
T10338 5833-5838 JJR denotes lower
T10339 5839-5853 NNS denotes concentrations
T10340 5854-5856 IN denotes of
T10341 5857-5859 NNP denotes FP
T10342 5859-5860 . denotes .
T10343 5861-5863 PRP denotes We
T10344 5864-5869 VBD denotes found
T10345 5870-5874 IN denotes that
T10346 5875-5877 NNP denotes FP
T10347 5878-5891 RB denotes significantly
T10348 5892-5899 VBD denotes induced
T10349 5900-5905 NNP denotes MKP-1
T10350 5906-5910 NNP denotes mRNA
T10351 5911-5913 IN denotes in
T10352 5914-5918 DT denotes both
T10353 5919-5920 DT denotes a
T10354 5921-5925 NN denotes time
T10355 5925-5926 : denotes -
T10356 5927-5930 CC denotes and
T10357 5931-5954 JJ denotes concentration-dependent
T10358 5955-5961 NN denotes manner
T10359 5961-5962 , denotes ,
T10360 5963-5971 VBG denotes reaching
T10361 5972-5973 DT denotes a
T10362 5974-5981 NN denotes plateau
T10363 5982-5984 IN denotes at
T10364 5985-5987 CD denotes 10
T10365 5987-5988 NN denotes −
T10366 5988-5989 CD denotes 8
T10367 5990-5991 NNP denotes M
T10368 5992-5997 IN denotes after
T10369 5998-6000 CD denotes 10
T10370 6001-6004 NN denotes min
T10371 6005-6006 -LRB- denotes (
T10372 6006-6012 NN denotes Figure
T10373 6013-6015 CD denotes 3D
T10374 6016-6019 CC denotes and
T10375 6020-6022 CD denotes 3E
T10376 6022-6023 -RRB- denotes )
T10377 6023-6024 . denotes .
T10378 6025-6032 RB denotes However
T10379 6032-6033 , denotes ,
T10380 6034-6037 DT denotes the
T10381 6038-6045 NNS denotes effects
T10382 6046-6048 IN denotes of
T10383 6049-6051 NNP denotes FP
T10384 6052-6054 IN denotes on
T10385 6055-6061 NNP denotes GATA-3
T10386 6062-6069 JJ denotes nuclear
T10387 6070-6076 NN denotes import
T10388 6076-6077 , denotes ,
T10389 6078-6088 JJ denotes importin-α
T10390 6089-6100 NN denotes association
T10391 6101-6104 CC denotes and
T10392 6105-6109 NN denotes IL-4
T10393 6110-6114 NNP denotes mRNA
T10394 6115-6125 NN denotes expression
T10395 6126-6129 VBP denotes are
T10396 6130-6134 VBN denotes seen
T10397 6135-6137 IN denotes at
T10398 6138-6149 CD denotes 10,000-fold
T10399 6150-6155 JJR denotes lower
T10400 6156-6170 NNS denotes concentrations
T10401 6171-6172 -LRB- denotes (
T10402 6172-6174 CD denotes 10
T10403 6174-6175 NN denotes −
T10404 6175-6177 CD denotes 12
T10405 6178-6179 NNP denotes M
T10406 6179-6180 , denotes ,
T10407 6181-6184 VBP denotes see
T10408 6185-6191 NN denotes Figure
T10409 6192-6193 CD denotes 2
T10410 6193-6194 -RRB- denotes )
T10411 6194-6195 . denotes .
T10412 7505-7510 VBG denotes Using
T10413 7511-7513 DT denotes an
T10414 7514-7516 IN denotes in
T10415 7517-7522 NN denotes vitro
T10416 7523-7534 NN denotes competition
T10417 7535-7540 NN denotes assay
T10418 7541-7542 -LRB- denotes (
T10419 7542-7548 NN denotes Figure
T10420 7549-7551 NN denotes 4A
T10421 7551-7552 -RRB- denotes )
T10422 7553-7562 VBG denotes utilizing
T10423 7563-7571 JJ denotes purified
T10424 7572-7581 VBN denotes activated
T10425 7582-7588 NN denotes GATA-3
T10426 7588-7589 , denotes ,
T10427 7590-7600 NN denotes importin-α
T10428 7600-7601 , denotes ,
T10429 7602-7605 CC denotes and
T10430 7606-7615 VBD denotes activated
T10431 7616-7618 NNP denotes GR
T10432 7618-7619 , denotes ,
T10433 7620-7622 PRP denotes we
T10434 7623-7635 VBD denotes demonstrated
T10435 7636-7640 IN denotes that
T10436 7641-7650 VBN denotes activated
T10437 7651-7653 NNP denotes GR
T10438 7654-7667 RB denotes significantly
T10439 7668-7677 VBD denotes increased
T10440 7678-7691 JJ denotes GR-importin-α
T10441 7692-7703 NN denotes association
T10442 7704-7706 IN denotes in
T10443 7707-7710 DT denotes the
T10444 7711-7719 NN denotes presence
T10445 7720-7723 CC denotes and
T10446 7724-7731 NN denotes absence
T10447 7732-7734 IN denotes of
T10448 7735-7744 VBN denotes activated
T10449 7745-7751 NNP denotes GATA-3
T10450 7752-7753 -LRB- denotes (
T10451 7753-7759 NNP denotes Figure
T10452 7760-7762 NNP denotes 4B
T10453 7762-7763 -RRB- denotes )
T10454 7763-7764 . denotes .
T10455 7765-7769 DT denotes This
T10456 7770-7776 NN denotes effect
T10457 7777-7779 VBZ denotes is
T10458 7780-7783 RB denotes not
T10459 7784-7790 JJ denotes mutual
T10460 7790-7791 , denotes ,
T10461 7792-7797 IN denotes since
T10462 7798-7807 VBN denotes activated
T10463 7808-7814 NNP denotes GATA-3
T10464 7815-7818 VBD denotes did
T10465 7819-7822 RB denotes not
T10466 7823-7828 VB denotes block
T10467 7829-7831 NNP denotes GR
T10468 7832-7842 JJ denotes importin-α
T10469 7843-7854 NN denotes association
T10470 7855-7856 -LRB- denotes (
T10471 7856-7862 NN denotes Figure
T10472 7863-7865 NN denotes 4C
T10473 7865-7866 -RRB- denotes )
T10474 7866-7867 . denotes .
T10475 7868-7873 DT denotes These
T10476 7874-7878 NNS denotes data
T10477 7879-7883 RB denotes also
T10478 7884-7891 VBP denotes suggest
T10479 7892-7896 IN denotes that
T10480 7897-7901 DT denotes both
T10481 7902-7911 VBN denotes activated
T10482 7912-7914 NNP denotes GR
T10483 7915-7918 CC denotes and
T10484 7919-7933 NNP denotes phospho-GATA-3
T10485 7934-7937 MD denotes can
T10486 7938-7946 RB denotes directly
T10487 7947-7956 VB denotes associate
T10488 7957-7961 IN denotes with
T10489 7962-7972 JJ denotes importin-α
T10490 7973-7974 -LRB- denotes (
T10491 7974-7980 NNP denotes Figure
T10492 7981-7983 NNP denotes 4D
T10493 7983-7984 -RRB- denotes )
T10494 7985-7988 CC denotes and
T10495 7989-7993 IN denotes that
T10496 7994-8003 VBN denotes activated
T10497 8004-8006 NNP denotes GR
T10498 8007-8017 VBZ denotes attenuates
T10499 8018-8021 DT denotes the
T10500 8022-8036 JJ denotes phospho-GATA-3
T10501 8036-8037 NN denotes /
T10502 8037-8047 JJ denotes importin-α
T10503 8048-8059 NN denotes interaction
T10504 8060-8062 IN denotes in
T10505 8063-8064 DT denotes a
T10506 8065-8088 JJ denotes concentration-dependent
T10507 8089-8095 NN denotes manner
T10508 8096-8097 -LRB- denotes (
T10509 8097-8103 NN denotes Figure
T10510 8104-8106 CD denotes 4E
T10511 8106-8107 -RRB- denotes )
T10512 8107-8108 . denotes .
T10513 8109-8117 RB denotes Together
T10514 8117-8118 , denotes ,
T10515 8119-8123 DT denotes this
T10516 8124-8132 VBZ denotes suggests
T10517 8133-8137 IN denotes that
T10518 8138-8154 JJ denotes ligand-activated
T10519 8155-8157 NNP denotes GR
T10520 8158-8161 MD denotes may
T10521 8162-8169 VB denotes compete
T10522 8170-8174 IN denotes with
T10523 8175-8189 JJ denotes phospho-GATA-3
T10524 8190-8193 IN denotes for
T10525 8194-8204 JJ denotes importin-α
T10526 8205-8208 CC denotes and
T10527 8209-8216 RB denotes thereby
T10528 8217-8222 NN denotes limit
T10529 8223-8229 JJ denotes GATA-3
T10530 8230-8237 JJ denotes nuclear
T10531 8238-8244 NN denotes import
T10532 8244-8245 . denotes .
T10533 9334-9339 JJ denotes Other
T10534 9340-9348 JJ denotes possible
T10535 9349-9364 NNS denotes interpretations
T10536 9365-9367 IN denotes of
T10537 9368-9371 PRP$ denotes our
T10538 9372-9379 NNS denotes results
T10539 9380-9385 MD denotes could
T10540 9386-9393 VB denotes include
T10541 9394-9396 DT denotes an
T10542 9397-9403 NN denotes effect
T10543 9404-9406 IN denotes of
T10544 9407-9409 NNP denotes FP
T10545 9410-9412 IN denotes on
T10546 9413-9419 NNP denotes GATA-3
T10547 9420-9427 JJ denotes nuclear
T10548 9428-9434 NN denotes export
T10549 9435-9441 CC denotes and/or
T10550 9442-9453 NN denotes degradation
T10551 9453-9454 . denotes .
T10552 9455-9465 NNP denotes Leptomycin
T10553 9466-9467 NNP denotes B
T10554 9467-9468 , denotes ,
T10555 9469-9474 WDT denotes which
T10556 9475-9483 VBZ denotes inhibits
T10557 9484-9491 JJ denotes nuclear
T10558 9492-9498 NN denotes export
T10559 9498-9499 , denotes ,
T10560 9500-9503 VBD denotes did
T10561 9504-9507 RB denotes not
T10562 9508-9514 VB denotes affect
T10563 9515-9518 DT denotes the
T10564 9519-9526 NN denotes ability
T10565 9527-9529 IN denotes of
T10566 9530-9532 NNP denotes FP
T10567 9533-9535 TO denotes to
T10568 9536-9541 VB denotes block
T10569 9542-9548 JJ denotes GATA-3
T10570 9549-9556 JJ denotes nuclear
T10571 9557-9569 NN denotes localization
T10572 9570-9571 -LRB- denotes (
T10573 9571-9577 NN denotes Figure
T10574 9578-9580 NN denotes 5A
T10575 9580-9581 -RRB- denotes )
T10576 9581-9582 . denotes .
T10577 9583-9595 RB denotes Additionally
T10578 9595-9596 , denotes ,
T10579 9597-9599 NNP denotes FP
T10580 9600-9603 VBD denotes had
T10581 9604-9606 DT denotes no
T10582 9607-9613 NN denotes effect
T10583 9614-9616 IN denotes on
T10584 9617-9622 JJ denotes whole
T10585 9623-9627 NN denotes cell
T10586 9628-9634 NN denotes GATA-3
T10587 9635-9645 NN denotes expression
T10588 9646-9652 IN denotes during
T10589 9653-9656 DT denotes the
T10590 9657-9661 NN denotes time
T10591 9662-9668 NN denotes course
T10592 9669-9671 IN denotes of
T10593 9672-9677 DT denotes these
T10594 9678-9689 NNS denotes experiments
T10595 9690-9691 -LRB- denotes (
T10596 9691-9697 NN denotes Figure
T10597 9698-9700 NN denotes 5B
T10598 9700-9701 -RRB- denotes )
T10599 9701-9702 . denotes .
T10600 9703-9706 CC denotes Nor
T10601 9707-9710 VBD denotes did
T10602 9711-9719 NN denotes addition
T10603 9720-9722 IN denotes of
T10604 9723-9725 NNP denotes FP
T10605 9726-9736 JJ denotes subsequent
T10606 9737-9739 TO denotes to
T10607 9740-9748 JJ denotes anti-CD3
T10608 9748-9749 NN denotes /
T10609 9749-9753 CD denotes CD28
T10610 9754-9761 JJ denotes nuclear
T10611 9762-9775 NN denotes translocation
T10612 9776-9782 VB denotes affect
T10613 9783-9789 JJ denotes GATA-3
T10614 9790-9797 JJ denotes nuclear
T10615 9798-9807 NN denotes residency
T10616 9808-9809 -LRB- denotes (
T10617 9809-9815 NN denotes Figure
T10618 9816-9818 NN denotes 5C
T10619 9818-9819 -RRB- denotes )
T10620 9819-9820 , denotes ,
T10621 9821-9831 VBG denotes suggesting
T10622 9832-9836 IN denotes that
T10623 9837-9846 VBN denotes activated
T10624 9847-9849 NNP denotes GR
T10625 9850-9854 VBZ denotes does
T10626 9855-9858 RB denotes not
T10627 9859-9866 VB denotes enhance
T10628 9867-9873 JJ denotes GATA-3
T10629 9874-9881 JJ denotes nuclear
T10630 9882-9888 NN denotes export
T10631 9888-9889 . denotes .
T10632 9890-9897 RB denotes Finally
T10633 9897-9898 , denotes ,
T10634 9899-9902 DT denotes the
T10635 9903-9909 NN denotes effect
T10636 9910-9912 IN denotes of
T10637 9913-9915 NNP denotes FP
T10638 9916-9918 IN denotes on
T10639 9919-9925 NNP denotes GATA-3
T10640 9926-9933 JJ denotes nuclear
T10641 9934-9940 NN denotes import
T10642 9941-9944 VBD denotes was
T10643 9945-9948 RB denotes not
T10644 9949-9960 JJ denotes nonspecific
T10645 9960-9961 , denotes ,
T10646 9962-9967 IN denotes since
T10647 9968-9970 NNP denotes FP
T10648 9971-9972 -LRB- denotes (
T10649 9972-9974 CD denotes 10
T10650 9974-9975 NN denotes −
T10651 9975-9976 CD denotes 8
T10652 9977-9978 NNP denotes M
T10653 9978-9979 -RRB- denotes )
T10654 9980-9983 VBD denotes had
T10655 9984-9986 DT denotes no
T10656 9987-9993 NN denotes effect
T10657 9994-9996 IN denotes on
T10658 9997-10000 CD denotes p65
T10659 10001-10008 JJ denotes nuclear
T10660 10009-10022 NN denotes translocation
T10661 10023-10031 VBN denotes measured
T10662 10032-10034 IN denotes at
T10663 10035-10037 CD denotes 60
T10664 10038-10041 NN denotes min
T10665 10042-10043 -LRB- denotes (
T10666 10043-10049 NN denotes Figure
T10667 10050-10052 CD denotes 5D
T10668 10052-10053 -RRB- denotes )
T10669 10053-10054 . denotes .
T11922 11106-11109 DT denotes The
T11923 11110-11120 NNP denotes Inhibitory
T11924 11121-11127 NN denotes Effect
T11925 11128-11130 IN denotes of
T11926 11131-11146 NNS denotes Corticosteroids
T11927 11147-11149 IN denotes on
T11928 11150-11156 NNP denotes GATA-3
T11929 11157-11164 NNP denotes Nuclear
T11930 11165-11177 NNP denotes Localization
T11931 11178-11180 IN denotes in
T11932 11181-11188 JJ denotes Primary
T11933 11189-11190 NNP denotes T
T11934 11191-11202 NNP denotes Lymphocytes
T11935 11203-11205 NNP denotes Ex
T11936 11206-11210 NNP denotes Vivo
T11937 11211-11214 CC denotes and
T11938 11215-11217 IN denotes In
T11939 11218-11222 NNP denotes Vivo
T11940 11223-11232 NNP denotes Treatment
T11941 11233-11237 IN denotes with
T11942 11238-11240 NNP denotes FP
T11943 11241-11243 FW denotes ex
T11944 11244-11248 FW denotes vivo
T11945 11249-11261 VBD denotes demonstrated
T11946 11262-11263 DT denotes a
T11947 11264-11287 JJ denotes concentration-dependent
T11948 11288-11296 NN denotes decrease
T11949 11297-11299 IN denotes in
T11950 11300-11303 DT denotes the
T11951 11304-11310 JJ denotes direct
T11952 11311-11322 NN denotes interaction
T11953 11323-11330 IN denotes between
T11954 11331-11345 JJ denotes phospho-GATA-3
T11955 11346-11349 CC denotes and
T11956 11350-11360 JJ denotes importin-α
T11957 11361-11363 IN denotes in
T11958 11364-11369 NNS denotes PBMCs
T11959 11370-11374 IN denotes from
T11960 11375-11383 NNS denotes patients
T11961 11384-11388 IN denotes with
T11962 11389-11395 NN denotes asthma
T11963 11396-11397 -LRB- denotes (
T11964 11397-11403 NN denotes Figure
T11965 11404-11406 NN denotes 6A
T11966 11407-11410 CC denotes and
T11967 11411-11413 NN denotes 6B
T11968 11413-11414 -RRB- denotes )
T11969 11414-11415 , denotes ,
T11970 11416-11421 WDT denotes which
T11971 11422-11425 VBD denotes was
T11972 11426-11439 RB denotes significantly
T11973 11440-11449 VBN denotes inhibited
T11974 11450-11452 IN denotes at
T11975 11453-11455 CD denotes 10
T11976 11455-11456 CD denotes −
T11977 11456-11458 CD denotes 12
T11978 11459-11460 NNP denotes M
T11979 11461-11463 NNP denotes FP
T11980 11464-11465 -LRB- denotes (
T11981 11465-11466 FW denotes p
T11982 11466-11467 FW denotes <
T11983 11467-11472 CD denotes 0.001
T11984 11472-11473 , denotes ,
T11985 11474-11479 NNP denotes ANOVA
T11986 11480-11483 CC denotes and
T11987 11484-11496 NNP denotes Newman-Keuls
T11988 11497-11501 NN denotes test
T11989 11501-11502 -RRB- denotes )
T11990 11503-11506 CC denotes and
T11991 11507-11517 RB denotes completely
T11992 11518-11528 VBN denotes attenuated
T11993 11529-11531 IN denotes by
T11994 11532-11534 CD denotes 10
T11995 11534-11535 NN denotes −
T11996 11535-11536 CD denotes 8
T11997 11537-11538 NNP denotes M
T11998 11539-11541 NNP denotes FP
T11999 11542-11543 -LRB- denotes (
T12000 11543-11544 FW denotes p
T12001 11544-11545 FW denotes <
T12002 11545-11550 CD denotes 0.001
T12003 11550-11551 , denotes ,
T12004 11552-11557 NNP denotes ANOVA
T12005 11558-11561 CC denotes and
T12006 11562-11574 NNP denotes Newman-Keuls
T12007 11575-11579 NN denotes test
T12008 11579-11580 -RRB- denotes )
T12009 11580-11581 . denotes .
T12010 12531-12534 PRP$ denotes Our
T12011 12535-12543 JJ denotes previous
T12012 12544-12545 NNP denotes T
T12013 12546-12550 NN denotes cell
T12014 12551-12555 NN denotes line
T12015 12556-12563 NNS denotes studies
T12016 12564-12573 VBD denotes indicated
T12017 12574-12578 IN denotes that
T12018 12579-12581 CD denotes 10
T12019 12581-12582 CD denotes −
T12020 12582-12584 CD denotes 12
T12021 12585-12586 NNP denotes M
T12022 12587-12589 NNP denotes FP
T12023 12590-12600 VBZ denotes suppresses
T12024 12601-12605 NN denotes IL-4
T12025 12606-12609 CC denotes and
T12026 12610-12612 CD denotes -5
T12027 12613-12617 NN denotes gene
T12028 12618-12628 NN denotes expression
T12029 12629-12632 CC denotes and
T12030 12633-12643 VBD denotes attenuated
T12031 12644-12647 DT denotes the
T12032 12648-12659 NN denotes interaction
T12033 12660-12662 IN denotes of
T12034 12663-12669 NN denotes GATA-3
T12035 12670-12674 IN denotes with
T12036 12675-12685 JJ denotes importin-α
T12037 12686-12687 -LRB- denotes (
T12038 12687-12690 VB denotes see
T12039 12691-12698 NNS denotes Figures
T12040 12699-12701 CD denotes 1D
T12041 12702-12705 CC denotes and
T12042 12706-12707 CD denotes 2
T12043 12707-12708 -RRB- denotes )
T12044 12708-12709 . denotes .
T12045 12710-12714 DT denotes This
T12046 12715-12728 NN denotes concentration
T12047 12729-12731 VBZ denotes is
T12048 12732-12737 JJ denotes close
T12049 12738-12740 TO denotes to
T12050 12741-12745 VB denotes peak
T12051 12746-12752 NN denotes plasma
T12052 12753-12759 NNS denotes levels
T12053 12760-12768 VBN denotes obtained
T12054 12769-12773 IN denotes from
T12055 12774-12783 JJ denotes asthmatic
T12056 12784-12792 NNS denotes patients
T12057 12793-12800 VBN denotes treated
T12058 12801-12805 IN denotes with
T12059 12806-12813 JJ denotes inhaled
T12060 12814-12816 NNP denotes FP
T12061 12817-12818 -LRB- denotes (
T12062 12818-12821 CD denotes 500
T12063 12822-12824 NN denotes µg
T12064 12824-12825 -RRB- denotes )
T12065 12826-12827 NNP denotes [
T12066 12827-12829 CD denotes 27
T12067 12829-12830 NNP denotes ]
T12068 12830-12831 . denotes .
T12069 12832-12839 VBN denotes Inhaled
T12070 12840-12842 NNP denotes FP
T12071 12843-12844 -LRB- denotes (
T12072 12844-12847 CD denotes 500
T12073 12848-12850 NN denotes µg
T12074 12850-12851 -RRB- denotes )
T12075 12852-12861 NN denotes treatment
T12076 12862-12864 IN denotes of
T12077 12865-12870 CD denotes seven
T12078 12871-12884 JJ denotes steroid-naive
T12079 12885-12891 NN denotes asthma
T12080 12892-12900 NNS denotes patients
T12081 12901-12914 RB denotes significantly
T12082 12915-12922 VBD denotes reduced
T12083 12923-12929 NNP denotes GATA-3
T12084 12930-12940 JJ denotes importin-α
T12085 12941-12952 NN denotes interaction
T12086 12953-12955 IN denotes in
T12087 12956-12960 NN denotes vivo
T12088 12961-12963 IN denotes in
T12089 12964-12965 DT denotes a
T12090 12966-12980 JJ denotes time-dependent
T12091 12981-12987 NN denotes manner
T12092 12987-12988 . denotes .
T12093 12989-12993 DT denotes This
T12094 12994-13002 VBD denotes produced
T12095 13003-13004 DT denotes a
T12096 13005-13006 NN denotes >
T12097 13006-13008 CD denotes 90
T12098 13008-13009 NN denotes %
T12099 13010-13018 NN denotes decrease
T12100 13019-13021 IN denotes in
T12101 13022-13028 NNP denotes GATA-3
T12102 13029-13039 JJ denotes importin-α
T12103 13040-13051 NN denotes association
T12104 13052-13054 IN denotes at
T12105 13055-13056 CD denotes 2
T12106 13057-13058 NN denotes h
T12107 13059-13060 -LRB- denotes (
T12108 13060-13066 JJ denotes median
T12109 13067-13068 NNP denotes [
T12110 13068-13070 CD denotes 95
T12111 13070-13071 NN denotes %
T12112 13072-13074 NNP denotes CI
T12113 13074-13075 NNP denotes ]
T12114 13075-13076 , denotes ,
T12115 13077-13083 CD denotes 13,494
T12116 13084-13085 NNP denotes [
T12117 13085-13090 CD denotes 6,828
T12118 13091-13097 CD denotes 17,829
T12119 13097-13098 NNP denotes ]
T12120 13099-13105 CC denotes versus
T12121 13106-13109 CD denotes 879
T12122 13110-13111 JJ denotes [
T12123 13111-13114 CD denotes 597
T12124 13115-13120 CD denotes 1,165
T12125 13120-13121 NNP denotes ]
T12126 13121-13122 : denotes ;
T12127 13123-13124 VB denotes p
T12128 13124-13125 RB denotes <
T12129 13125-13129 CD denotes 0.05
T12130 13130-13138 NNP denotes Friedman
T12131 13138-13140 POS denotes 's
T12132 13141-13149 NN denotes analysis
T12133 13149-13150 -RRB- denotes )
T12134 13150-13151 . denotes .
T12135 13152-13159 RB denotes However
T12136 13159-13160 , denotes ,
T12137 13161-13165 DT denotes this
T12138 13166-13169 VBD denotes did
T12139 13170-13173 RB denotes not
T12140 13174-13179 VB denotes reach
T12141 13180-13192 NN denotes significance
T12142 13193-13198 VBG denotes using
T12143 13199-13207 NNP denotes Wilcoxon
T12144 13207-13209 POS denotes 's
T12145 13210-13219 JJ denotes post-test
T12146 13220-13228 NN denotes analysis
T12147 13229-13230 -LRB- denotes (
T12148 13230-13231 NNP denotes W
T12149 13232-13233 SYM denotes =
T12150 13234-13238 CD denotes 6.00
T12151 13238-13239 -RRB- denotes )
T12152 13240-13248 RB denotes probably
T12153 13249-13252 JJ denotes due
T12154 13253-13255 TO denotes to
T12155 13256-13259 JJ denotes low
T12156 13260-13267 NNS denotes numbers
T12157 13268-13270 IN denotes of
T12158 13271-13283 NNS denotes participants
T12159 13283-13284 . denotes .
T12160 13285-13292 JJ denotes Similar
T12161 13293-13300 NNS denotes results
T12162 13301-13305 VBD denotes were
T12163 13306-13314 VBN denotes observed
T12164 13315-13319 WRB denotes when
T12165 13320-13326 NNP denotes GATA-3
T12166 13327-13337 JJ denotes importin-α
T12167 13338-13349 NN denotes association
T12168 13350-13353 VBD denotes was
T12169 13354-13362 VBN denotes measured
T12170 13363-13364 -LRB- denotes (
T12171 13364-13370 NNP denotes Figure
T12172 13371-13373 NNP denotes 6C
T12173 13374-13377 CC denotes and
T12174 13378-13380 NNP denotes 6D
T12175 13380-13381 -RRB- denotes )
T12176 13381-13382 . denotes .
T12177 13383-13386 DT denotes The
T12178 13387-13392 JJR denotes lower
T12179 13393-13397 NN denotes dose
T12180 13398-13400 IN denotes of
T12181 13401-13403 NNP denotes FP
T12182 13404-13405 -LRB- denotes (
T12183 13405-13408 CD denotes 100
T12184 13409-13411 NN denotes µg
T12185 13411-13412 -RRB- denotes )
T12186 13413-13416 VBD denotes was
T12187 13417-13420 RB denotes not
T12188 13421-13430 JJ denotes effective
T12189 13430-13431 . denotes .
T12190 13432-13435 DT denotes The
T12191 13436-13446 JJ denotes attenuated
T12192 13447-13458 NN denotes interaction
T12193 13459-13461 IN denotes of
T12194 13462-13468 NN denotes GATA-3
T12195 13469-13472 VBD denotes did
T12196 13473-13476 RB denotes not
T12197 13477-13483 VB denotes result
T12198 13484-13488 IN denotes from
T12199 13489-13492 DT denotes the
T12200 13493-13502 JJ denotes defective
T12201 13503-13512 NN denotes recycling
T12202 13513-13515 IN denotes of
T12203 13516-13526 NN denotes importin-α
T12204 13526-13527 , denotes ,
T12205 13528-13530 IN denotes as
T12206 13531-13532 DT denotes a
T12207 13533-13544 JJ denotes significant
T12208 13545-13553 NN denotes decrease
T12209 13554-13556 IN denotes in
T12210 13557-13560 DT denotes the
T12211 13561-13570 NN denotes abundance
T12212 13571-13573 IN denotes of
T12213 13574-13584 NN denotes importin-α
T12214 13585-13587 IN denotes in
T12215 13588-13591 DT denotes the
T12216 13592-13603 JJ denotes cytoplasmic
T12217 13604-13608 NN denotes pool
T12218 13609-13612 VBD denotes was
T12219 13613-13616 RB denotes not
T12220 13617-13625 VBN denotes detected
T12221 13626-13627 -LRB- denotes (
T12222 13627-13633 NN denotes Figure
T12223 13634-13636 CD denotes 6E
T12224 13636-13637 -RRB- denotes )
T12225 13637-13638 . denotes .
T12226 13639-13641 PRP denotes We
T12227 13642-13649 RB denotes further
T12228 13650-13658 VBD denotes examined
T12229 13659-13666 IN denotes whether
T12230 13667-13674 JJ denotes inhaled
T12231 13675-13677 NNP denotes FP
T12232 13678-13683 MD denotes could
T12233 13684-13690 VB denotes affect
T12234 13691-13699 JJ denotes cellular
T12235 13700-13712 NN denotes localization
T12236 13713-13715 IN denotes of
T12237 13716-13722 NN denotes GATA-3
T12238 13723-13725 IN denotes in
T12239 13726-13736 JJ denotes peripheral
T12240 13737-13742 NN denotes blood
T12241 13743-13744 NNP denotes T
T12242 13745-13750 NNS denotes cells
T12243 13750-13751 . denotes .
T12244 13752-13761 NNP denotes Treatment
T12245 13762-13766 IN denotes with
T12246 13767-13774 JJ denotes inhaled
T12247 13775-13777 NNP denotes FP
T12248 13778-13779 -LRB- denotes (
T12249 13779-13782 CD denotes 500
T12250 13783-13785 NN denotes µg
T12251 13785-13786 -RRB- denotes )
T12252 13787-13790 IN denotes for
T12253 13791-13792 CD denotes 2
T12254 13793-13794 NN denotes h
T12255 13795-13808 RB denotes significantly
T12256 13809-13818 VBD denotes increased
T12257 13819-13821 NNP denotes GR
T12258 13822-13829 JJ denotes nuclear
T12259 13830-13843 NN denotes translocation
T12260 13844-13845 -LRB- denotes (
T12261 13845-13851 NN denotes Figure
T12262 13852-13854 NN denotes 7A
T12263 13854-13855 -RRB- denotes )
T12264 13856-13859 CC denotes and
T12265 13860-13873 RB denotes concomitantly
T12266 13874-13883 VBD denotes decreased
T12267 13884-13887 DT denotes the
T12268 13888-13894 NN denotes number
T12269 13895-13897 IN denotes of
T12270 13898-13905 JJ denotes nuclear
T12271 13906-13912 JJ denotes GATA-3
T12272 13913-13927 JJ denotes immunoreactive
T12273 13928-13938 JJ denotes peripheral
T12274 13939-13944 NN denotes blood
T12275 13945-13946 NNP denotes T
T12276 13947-13952 NNS denotes cells
T12277 13953-13954 -LRB- denotes (
T12278 13954-13956 CD denotes 37
T12279 13956-13957 NN denotes %
T12280 13957-13958 CD denotes ±
T12281 13958-13961 CD denotes 4.2
T12282 13961-13962 NN denotes %
T12283 13963-13969 CC denotes versus
T12284 13970-13974 CD denotes 58.2
T12285 13974-13975 NN denotes %
T12286 13975-13976 CD denotes ±
T12287 13976-13980 CD denotes 4.95
T12288 13980-13981 NN denotes %
T12289 13981-13982 , denotes ,
T12290 13983-13984 VBP denotes p
T12291 13985-13986 SYM denotes =
T12292 13987-13992 CD denotes 0.016
T12293 13992-13993 , denotes ,
T12294 13994-13995 NNP denotes W
T12295 13996-13997 SYM denotes =
T12296 13998-14002 CD denotes 28.0
T12297 14002-14003 , denotes ,
T12298 14004-14012 NNP denotes Wilcoxon
T12299 14012-14014 POS denotes 's
T12300 14015-14019 NN denotes rank
T12301 14020-14024 NN denotes test
T12302 14024-14025 -RRB- denotes )
T12303 14026-14034 VBN denotes compared
T12304 14035-14039 IN denotes with
T12305 14040-14047 NN denotes placebo
T12306 14048-14050 IN denotes as
T12307 14051-14059 VBN denotes measured
T12308 14060-14062 IN denotes by
T12309 14063-14082 NN denotes immunocytochemistry
T12310 14083-14084 -LRB- denotes (
T12311 14084-14090 NN denotes Figure
T12312 14091-14093 NN denotes 7A
T12313 14094-14097 CC denotes and
T12314 14098-14100 NN denotes 7B
T12315 14100-14101 -RRB- denotes )
T12316 14101-14102 . denotes .
T12317 14103-14107 DT denotes This
T12318 14108-14111 VBD denotes was
T12319 14112-14121 VBN denotes confirmed
T12320 14122-14124 IN denotes by
T12321 14125-14132 JJ denotes Western
T12322 14133-14141 VBG denotes blotting
T12323 14141-14142 , denotes ,
T12324 14143-14148 WDT denotes which
T12325 14149-14153 RB denotes also
T12326 14154-14163 VBD denotes indicated
T12327 14164-14168 IN denotes that
T12328 14169-14173 DT denotes this
T12329 14174-14180 NN denotes effect
T12330 14181-14184 VBD denotes was
T12331 14185-14189 DT denotes both
T12332 14190-14194 NN denotes time
T12333 14194-14195 : denotes -
T12334 14196-14199 CC denotes and
T12335 14200-14214 JJ denotes dose-dependent
T12336 14215-14216 -LRB- denotes (
T12337 14216-14222 NNP denotes Figure
T12338 14223-14225 NNP denotes 7C
T12339 14226-14229 CC denotes and
T12340 14230-14232 NNP denotes 7D
T12341 14232-14233 -RRB- denotes )
T12342 14233-14234 . denotes .
T12343 14235-14239 RB denotes Thus
T12344 14239-14240 , denotes ,
T12345 14241-14248 VBD denotes inhaled
T12346 14249-14251 NNP denotes FP
T12347 14252-14253 -LRB- denotes (
T12348 14253-14256 CD denotes 500
T12349 14257-14259 NN denotes µg
T12350 14259-14260 -RRB- denotes )
T12351 14261-14268 VBD denotes induced
T12352 14269-14280 JJ denotes significant
T12353 14281-14285 NN denotes loss
T12354 14286-14288 IN denotes in
T12355 14289-14296 JJ denotes nuclear
T12356 14297-14303 NN denotes GATA-3
T12357 14304-14306 IN denotes at
T12358 14307-14308 CD denotes 2
T12359 14309-14310 NN denotes h
T12360 14311-14312 -LRB- denotes (
T12361 14312-14318 JJ denotes median
T12362 14319-14320 NNP denotes [
T12363 14320-14322 CD denotes 95
T12364 14322-14323 NN denotes %
T12365 14324-14326 NNP denotes CI
T12366 14326-14327 NNP denotes ]
T12367 14327-14328 , denotes ,
T12368 14329-14333 CD denotes 0.40
T12369 14334-14335 NNP denotes [
T12370 14335-14339 CD denotes 0.27
T12371 14340-14344 CD denotes 0.53
T12372 14344-14345 NNP denotes ]
T12373 14346-14352 CC denotes versus
T12374 14353-14357 CD denotes 0.14
T12375 14358-14359 NNP denotes [
T12376 14359-14363 CD denotes 0.11
T12377 14364-14368 CD denotes 0.19
T12378 14368-14369 NNP denotes ]
T12379 14369-14370 , denotes ,
T12380 14371-14372 NN denotes p
T12381 14372-14373 NN denotes <
T12382 14373-14377 CD denotes 0.05
T12383 14377-14378 , denotes ,
T12384 14379-14380 NNP denotes W
T12385 14381-14382 SYM denotes =
T12386 14383-14388 CD denotes 21.00
T12387 14388-14389 , denotes ,
T12388 14390-14398 NNP denotes Wilcoxon
T12389 14398-14400 POS denotes 's
T12390 14401-14405 NN denotes rank
T12391 14406-14410 NN denotes test
T12392 14410-14411 -RRB- denotes )
T12393 14412-14413 -LRB- denotes (
T12394 14413-14419 NN denotes Figure
T12395 14420-14422 NN denotes 7C
T12396 14422-14423 -RRB- denotes )
T12397 14424-14427 CC denotes and
T12398 14428-14439 JJ denotes cytoplasmic
T12399 14440-14446 NN denotes GATA-3
T12400 14447-14453 NNS denotes levels
T12401 14454-14458 VBD denotes were
T12402 14459-14467 VBN denotes enhanced
T12403 14468-14470 IN denotes by
T12404 14471-14478 JJ denotes inhaled
T12405 14479-14481 NNP denotes FP
T12406 14482-14484 IN denotes in
T12407 14485-14486 DT denotes a
T12408 14487-14501 JJ denotes dose-dependent
T12409 14502-14508 NN denotes manner
T12410 14509-14510 -LRB- denotes (
T12411 14510-14516 JJ denotes median
T12412 14517-14518 NNP denotes [
T12413 14518-14520 CD denotes 95
T12414 14520-14521 NN denotes %
T12415 14522-14524 NNP denotes CI
T12416 14524-14525 NNP denotes ]
T12417 14525-14526 , denotes ,
T12418 14527-14533 CD denotes 0.0032
T12419 14534-14535 NNP denotes [
T12420 14535-14541 CD denotes 0.0026
T12421 14542-14548 CD denotes 0.0039
T12422 14548-14549 NNP denotes ]
T12423 14550-14556 CC denotes versus
T12424 14557-14562 CD denotes 0.658
T12425 14563-14564 NNP denotes [
T12426 14564-14569 CD denotes 0.592
T12427 14570-14575 CD denotes 0.720
T12428 14575-14576 NNP denotes ]
T12429 14576-14577 , denotes ,
T12430 14578-14579 NN denotes p
T12431 14579-14580 NN denotes <
T12432 14580-14584 CD denotes 0.05
T12433 14584-14585 , denotes ,
T12434 14586-14587 NNP denotes W
T12435 14588-14589 SYM denotes =
T12436 14590-14591 FW denotes −
T12437 14591-14596 CD denotes 21.00
T12438 14596-14597 , denotes ,
T12439 14598-14606 NNP denotes Wilcoxon
T12440 14606-14608 POS denotes 's
T12441 14609-14613 NN denotes rank
T12442 14614-14618 NN denotes test
T12443 14618-14619 -RRB- denotes )
T12444 14620-14621 -LRB- denotes (
T12445 14621-14627 NNP denotes Figure
T12446 14628-14630 NNP denotes 7D
T12447 14630-14631 -RRB- denotes )
T12448 14631-14632 . denotes .
T12449 14633-14635 IN denotes In
T12450 14636-14644 NN denotes addition
T12451 14644-14645 , denotes ,
T12452 14646-14648 NNP denotes FP
T12453 14649-14650 -LRB- denotes (
T12454 14650-14653 CD denotes 500
T12455 14654-14656 NN denotes µg
T12456 14656-14657 -RRB- denotes )
T12457 14658-14667 VBD denotes inhibited
T12458 14668-14671 CD denotes p38
T12459 14672-14676 NNP denotes MAPK
T12460 14677-14692 NN denotes phosphorylation
T12461 14693-14695 IN denotes in
T12462 14696-14703 JJ denotes primary
T12463 14704-14705 NNP denotes T
T12464 14706-14711 NNS denotes cells
T12465 14712-14714 IN denotes in
T12466 14715-14719 NN denotes vivo
T12467 14720-14722 IN denotes at
T12468 14723-14724 CD denotes 2
T12469 14725-14726 NN denotes h
T12470 14727-14729 IN denotes in
T12471 14730-14737 NNS denotes samples
T12472 14738-14742 IN denotes from
T12473 14743-14746 CD denotes two
T12474 14747-14755 NNS denotes patients
T12475 14756-14757 -LRB- denotes (
T12476 14757-14763 NN denotes Figure
T12477 14764-14766 CD denotes 7E
T12478 14766-14767 -RRB- denotes )
T12479 14767-14768 . denotes .
T12480 16255-16260 VBN denotes Taken
T12481 16261-16269 RB denotes together
T12482 16269-16270 , denotes ,
T12483 16271-16274 PRP$ denotes our
T12484 16275-16279 NNS denotes data
T12485 16280-16287 VBP denotes suggest
T12486 16288-16292 IN denotes that
T12487 16293-16300 VBD denotes inhaled
T12488 16301-16303 NNP denotes FP
T12489 16304-16311 VBZ denotes reduces
T12490 16312-16319 JJ denotes nuclear
T12491 16320-16332 NN denotes localization
T12492 16333-16335 IN denotes of
T12493 16336-16342 NN denotes GATA-3
T12494 16343-16345 IN denotes in
T12495 16346-16350 NN denotes vivo
T12496 16351-16353 IN denotes by
T12497 16354-16361 RB denotes acutely
T12498 16362-16372 VBG denotes inhibiting
T12499 16373-16387 JJ denotes phospho-GATA-3
T12500 16388-16396 NN denotes importin
T12501 16397-16408 NN denotes association
T12502 16408-16409 . denotes .
T12503 16410-16414 DT denotes This
T12504 16415-16421 NN denotes effect
T12505 16422-16425 MD denotes may
T12506 16426-16428 VB denotes be
T12507 16429-16435 JJ denotes direct
T12508 16435-16436 , denotes ,
T12509 16437-16444 IN denotes through
T12510 16445-16456 NN denotes competition
T12511 16457-16460 IN denotes for
T12512 16461-16471 JJ denotes importin-α
T12513 16472-16474 CC denotes or
T12514 16475-16485 VBN denotes associated
T12515 16486-16495 NNS denotes molecules
T12516 16495-16496 , denotes ,
T12517 16497-16499 CC denotes or
T12518 16500-16509 JJ denotes secondary
T12519 16510-16512 TO denotes to
T12520 16513-16515 DT denotes an
T12521 16516-16522 NN denotes effect
T12522 16523-16525 IN denotes on
T12523 16526-16529 CD denotes p38
T12524 16530-16543 JJ denotes MAPK-mediated
T12525 16544-16550 JJ denotes GATA-3
T12526 16551-16566 NN denotes phosphorylation
T12527 16567-16570 IN denotes via
T12528 16571-16576 JJ denotes rapid
T12529 16577-16586 NN denotes induction
T12530 16587-16589 IN denotes of
T12531 16590-16595 NN denotes MKP-1
T12532 16595-16596 . denotes .
T12533 16597-16600 DT denotes The
T12534 16601-16612 NN denotes combination
T12535 16613-16615 IN denotes of
T12536 16616-16621 DT denotes these
T12537 16622-16625 CD denotes two
T12538 16626-16637 VBG denotes interacting
T12539 16638-16645 NNS denotes effects
T12540 16646-16649 MD denotes can
T12541 16650-16656 VB denotes result
T12542 16657-16659 IN denotes in
T12543 16660-16668 JJ denotes complete
T12544 16669-16680 NN denotes suppression
T12545 16681-16683 IN denotes of
T12546 16684-16690 JJ denotes GATA-3
T12547 16691-16698 JJ denotes nuclear
T12548 16699-16705 NN denotes import
T12549 16706-16709 CC denotes and
T12550 16710-16714 RB denotes thus
T12551 16715-16718 JJ denotes Th2
T12552 16719-16727 NN denotes cytokine
T12553 16728-16732 NN denotes gene
T12554 16733-16743 NN denotes expression
T12555 16743-16744 . denotes .
T16315 1156-1167 NNP denotes Fluticasone
T16316 1168-1178 JJ denotes propionate
T16317 1179-1193 NNS denotes down-regulates
T16318 1194-1197 JJ denotes Th2
T16319 1198-1206 NN denotes cytokine
T16320 1207-1211 NN denotes gene
T16321 1212-1222 NN denotes expression
T16322 1223-1226 CC denotes and
T16323 1227-1235 NNS denotes inhibits
T16324 1236-1242 JJ denotes GATA-3
T16325 1243-1250 JJ denotes nuclear
T16326 1251-1257 NN denotes import
T16327 1257-1258 . denotes .
T16328 1259-1260 -LRB- denotes (
T16329 1260-1261 NNP denotes A
T16330 1261-1262 -RRB- denotes )
T16331 1263-1271 JJ denotes Anti-CD3
T16332 1271-1272 NN denotes /
T16333 1272-1276 CD denotes CD28
T16334 1277-1286 NN denotes treatment
T16335 1287-1289 IN denotes of
T16336 1290-1296 JJ denotes HuT-78
T16337 1297-1302 NNS denotes cells
T16338 1303-1310 NNS denotes results
T16339 1311-1313 IN denotes in
T16340 1314-1327 NN denotes translocation
T16341 1328-1330 IN denotes of
T16342 1331-1337 NN denotes GATA-3
T16343 1338-1342 IN denotes from
T16344 1343-1346 DT denotes the
T16345 1347-1356 NN denotes cytoplasm
T16346 1357-1359 TO denotes to
T16347 1360-1363 DT denotes the
T16348 1364-1371 NN denotes nucleus
T16349 1372-1378 IN denotes within
T16350 1379-1381 CD denotes 30
T16351 1382-1385 NN denotes min
T16352 1385-1386 . denotes .
T16353 1387-1388 -LRB- denotes (
T16354 1388-1389 NNP denotes B
T16355 1389-1390 -RRB- denotes )
T16356 1391-1398 NNP denotes Histone
T16357 1399-1401 NNP denotes H1
T16358 1402-1405 CC denotes and
T16359 1406-1411 NNP denotes MEK-1
T16360 1412-1416 VBD denotes were
T16361 1417-1421 VBN denotes used
T16362 1422-1424 TO denotes to
T16363 1425-1432 VB denotes confirm
T16364 1433-1441 JJ denotes distinct
T16365 1442-1452 NN denotes separation
T16366 1453-1455 IN denotes of
T16367 1456-1467 JJ denotes cytoplasmic
T16368 1468-1471 CC denotes and
T16369 1472-1479 JJ denotes nuclear
T16370 1480-1488 NNS denotes extracts
T16371 1489-1491 IN denotes in
T16372 1492-1497 CD denotes three
T16373 1498-1506 JJ denotes separate
T16374 1507-1518 NNS denotes experiments
T16375 1518-1519 . denotes .
T16376 1520-1521 -LRB- denotes (
T16377 1521-1522 $ denotes C
T16378 1522-1523 -RRB- denotes )
T16379 1524-1531 JJ denotes Western
T16380 1532-1536 NN denotes blot
T16381 1537-1545 NN denotes analysis
T16382 1546-1548 IN denotes of
T16383 1549-1559 JJ denotes FP-treated
T16384 1560-1566 JJ denotes HuT-78
T16385 1567-1572 NNS denotes cells
T16386 1573-1585 VBD denotes demonstrated
T16387 1586-1594 VBN denotes impaired
T16388 1595-1602 JJ denotes nuclear
T16389 1603-1615 NN denotes localization
T16390 1616-1618 IN denotes of
T16391 1619-1625 JJ denotes GATA-3
T16392 1626-1633 VBN denotes induced
T16393 1634-1636 IN denotes by
T16394 1637-1645 JJ denotes anti-CD3
T16395 1645-1646 NN denotes /
T16396 1646-1650 CD denotes CD28
T16397 1651-1665 NN denotes co-stimulation
T16398 1666-1668 IN denotes in
T16399 1669-1670 DT denotes a
T16400 1671-1675 NN denotes time
T16401 1675-1676 : denotes -
T16402 1677-1678 -LRB- denotes (
T16403 1678-1680 IN denotes at
T16404 1681-1683 CD denotes 10
T16405 1683-1684 NN denotes −
T16406 1684-1685 CD denotes 8
T16407 1686-1687 NNP denotes M
T16408 1688-1690 NNP denotes FP
T16409 1690-1691 -RRB- denotes )
T16410 1692-1695 CC denotes and
T16411 1696-1709 NN denotes concentration
T16412 1709-1710 : denotes -
T16413 1711-1712 -LRB- denotes (
T16414 1712-1714 IN denotes at
T16415 1715-1717 CD denotes 60
T16416 1718-1721 NN denotes min
T16417 1722-1727 IN denotes after
T16418 1728-1739 NN denotes stimulation
T16419 1739-1740 -RRB- denotes )
T16420 1741-1750 JJ denotes dependent
T16421 1751-1757 NN denotes manner
T16422 1757-1758 . denotes .
T16423 1759-1764 NNS denotes Cells
T16424 1765-1769 VBD denotes were
T16425 1770-1780 VBN denotes pretreated
T16426 1781-1785 IN denotes with
T16427 1786-1788 NNP denotes FP
T16428 1789-1792 IN denotes for
T16429 1793-1795 CD denotes 30
T16430 1796-1799 NN denotes min
T16431 1800-1805 RB denotes prior
T16432 1806-1808 TO denotes to
T16433 1809-1820 NN denotes stimulation
T16434 1820-1821 . denotes .
T16435 1822-1826 CD denotes MEK1
T16436 1827-1830 CC denotes and
T16437 1831-1838 VB denotes histone
T16438 1839-1841 CD denotes H1
T16439 1842-1846 VBD denotes were
T16440 1847-1851 VBN denotes used
T16441 1852-1854 TO denotes to
T16442 1855-1866 VB denotes demonstrate
T16443 1867-1872 JJ denotes equal
T16444 1873-1884 JJ denotes cytoplasmic
T16445 1885-1888 CC denotes and
T16446 1889-1896 JJ denotes nuclear
T16447 1897-1904 VBG denotes loading
T16448 1905-1917 RB denotes respectively
T16449 1917-1918 . denotes .
T16450 1919-1926 NNS denotes Results
T16451 1927-1930 VBP denotes are
T16452 1931-1940 VBN denotes presented
T16453 1941-1952 RB denotes graphically
T16454 1953-1958 IN denotes below
T16455 1959-1961 IN denotes as
T16456 1962-1966 JJ denotes mean
T16457 1966-1967 NN denotes ±
T16458 1967-1970 NNP denotes SEM
T16459 1971-1973 IN denotes of
T16460 1974-1976 IN denotes at
T16461 1977-1982 JJS denotes least
T16462 1983-1988 CD denotes three
T16463 1989-2000 JJ denotes independent
T16464 2001-2012 NNS denotes experiments
T16465 2012-2013 . denotes .
T16466 2014-2017 FW denotes ***
T16467 2018-2019 FW denotes p
T16468 2019-2020 FW denotes <
T16469 2020-2025 CD denotes 0.001
T16470 2026-2034 VBN denotes compared
T16471 2035-2037 TO denotes to
T16472 2038-2039 VB denotes t
T16473 2040-2041 SYM denotes =
T16474 2042-2043 CD denotes 0
T16475 2043-2044 . denotes .
T16476 2045-2046 -LRB- denotes (
T16477 2046-2047 NNP denotes D
T16478 2047-2048 -RRB- denotes )
T16479 2049-2055 NNP denotes RT-PCR
T16480 2056-2063 VBG denotes showing
T16481 2064-2068 IN denotes that
T16482 2069-2071 NNP denotes FP
T16483 2072-2080 VBZ denotes inhibits
T16484 2081-2085 NN denotes IL-4
T16485 2086-2089 CC denotes and
T16486 2090-2094 NN denotes IL-5
T16487 2095-2099 NNP denotes mRNA
T16488 2100-2110 NN denotes expression
T16489 2111-2113 IN denotes in
T16490 2114-2135 JJ denotes CD3/CD28-costimulated
T16491 2136-2141 NNS denotes cells
T16492 2141-2142 . denotes .
T16493 2143-2148 NNP denotes GAPDH
T16494 2149-2152 VBD denotes was
T16495 2153-2157 VBN denotes used
T16496 2158-2160 IN denotes as
T16497 2161-2162 DT denotes a
T16498 2163-2170 VBG denotes loading
T16499 2171-2178 NN denotes control
T16500 2178-2179 . denotes .
T16501 2180-2185 JJR denotes Lower
T16502 2186-2192 NNS denotes panels
T16503 2193-2197 VBP denotes show
T16504 2198-2207 JJ denotes graphical
T16505 2208-2216 NN denotes analysis
T16506 2217-2219 IN denotes of
T16507 2220-2227 NNS denotes results
T16508 2228-2237 VBN denotes presented
T16509 2238-2240 IN denotes as
T16510 2241-2245 JJ denotes mean
T16511 2245-2246 NN denotes ±
T16512 2246-2249 NNP denotes SEM
T16513 2250-2252 IN denotes of
T16514 2253-2255 IN denotes at
T16515 2256-2261 JJS denotes least
T16516 2262-2267 CD denotes three
T16517 2268-2279 JJ denotes independent
T16518 2280-2291 NNS denotes experiments
T16519 2291-2292 . denotes .
T16520 2293-2296 FW denotes ###
T16521 2018-2019 FW denotes p
T16522 2019-2020 FW denotes <
T16523 2020-2025 CD denotes 0.001
T16524 2026-2034 VBN denotes compared
T16525 2035-2037 TO denotes to
T16526 2317-2324 VB denotes control
T16527 2324-2325 , denotes ,
T16528 2326-2329 FW denotes ***
T16529 2329-2330 FW denotes p
T16530 2330-2331 FW denotes <
T16531 2331-2336 CD denotes 0.001
T16532 2337-2345 VBN denotes compared
T16533 2346-2348 TO denotes to
T16534 2349-2357 JJ denotes anti-CD3
T16535 2357-2358 NN denotes /
T16536 2358-2362 CD denotes CD28
T16537 2363-2373 VBN denotes stimulated
T16538 2373-2374 . denotes .
T16539 2375-2376 -LRB- denotes (
T16540 2376-2377 NNP denotes E
T16541 2377-2378 -RRB- denotes )
T16542 2379-2381 NNP denotes FP
T16543 2382-2383 -LRB- denotes (
T16544 2383-2385 CD denotes 10
T16545 2386-2388 NNP denotes nM
T16546 2388-2389 -RRB- denotes )
T16547 2390-2397 VBZ denotes reduces
T16548 2398-2401 DT denotes the
T16549 2402-2409 NN denotes ability
T16550 2410-2412 IN denotes of
T16551 2413-2421 JJ denotes anti-CD3
T16552 2421-2422 NN denotes /
T16553 2422-2437 JJ denotes CD28-stimulated
T16554 2438-2444 NN denotes GATA-3
T16555 2445-2447 TO denotes to
T16556 2448-2457 VB denotes associate
T16557 2458-2462 IN denotes with
T16558 2463-2466 DT denotes the
T16559 2467-2473 JJ denotes native
T16560 2474-2478 NN denotes IL-5
T16561 2479-2487 NN denotes promoter
T16562 2488-2490 CD denotes 60
T16563 2491-2494 NN denotes min
T16564 2495-2500 IN denotes after
T16565 2501-2512 NN denotes stimulation
T16566 2512-2513 . denotes .
T16567 2514-2518 NNS denotes Data
T16568 2519-2522 VBP denotes are
T16569 2523-2527 RB denotes also
T16570 2528-2533 VBN denotes shown
T16571 2534-2545 RB denotes graphically
T16572 2546-2548 IN denotes as
T16573 2549-2553 JJ denotes mean
T16574 2553-2554 NN denotes ±
T16575 2554-2557 NNP denotes SEM
T16576 2558-2560 IN denotes of
T16577 2561-2566 CD denotes three
T16578 2567-2578 JJ denotes independent
T16579 2579-2590 NNS denotes experiments
T16580 2590-2591 . denotes .
T16581 2592-2595 DT denotes All
T16582 2596-2600 NNS denotes data
T16583 2601-2605 VBD denotes were
T16584 2606-2614 VBN denotes analysed
T16585 2615-2617 IN denotes by
T16586 2618-2623 NNP denotes ANOVA
T16587 2624-2632 VBD denotes followed
T16588 2633-2635 IN denotes by
T16589 2636-2648 NNP denotes Newman-Keuls
T16590 2649-2658 JJS denotes post-test
T16591 2658-2659 . denotes .
T17105 3572-3583 NNP denotes Fluticasone
T17106 3584-3594 NN denotes propionate
T17107 3595-3602 VBZ denotes reduces
T17108 3603-3609 JJ denotes GATA-3
T17109 3610-3621 NN denotes association
T17110 3622-3626 IN denotes with
T17111 3627-3637 JJ denotes importin-α
T17112 3638-3641 CC denotes and
T17113 3642-3648 JJ denotes GATA-3
T17114 3649-3656 JJ denotes nuclear
T17115 3657-3663 NN denotes import
T17116 3663-3664 . denotes .
T17117 3665-3666 -LRB- denotes (
T17118 3666-3667 NN denotes A
T17119 3667-3668 -RRB- denotes )
T17120 3669-3676 JJ denotes Western
T17121 3677-3681 NN denotes blot
T17122 3682-3690 NN denotes analysis
T17123 3691-3703 VBZ denotes demonstrates
T17124 3704-3705 DT denotes a
T17125 3706-3710 NN denotes time
T17126 3710-3711 : denotes -
T17127 3712-3713 -LRB- denotes (
T17128 3713-3715 IN denotes at
T17129 3716-3718 CD denotes 10
T17130 3718-3719 NN denotes −
T17131 3719-3720 CD denotes 8
T17132 3721-3722 NNP denotes M
T17133 3723-3725 NNP denotes FP
T17134 3725-3726 -RRB- denotes )
T17135 3727-3730 CC denotes and
T17136 3731-3744 NN denotes concentration
T17137 3744-3745 : denotes -
T17138 3746-3747 -LRB- denotes (
T17139 3747-3749 IN denotes at
T17140 3750-3752 CD denotes 60
T17141 3753-3756 NN denotes min
T17142 3757-3762 IN denotes after
T17143 3763-3774 NN denotes stimulation
T17144 3774-3775 -RRB- denotes )
T17145 3776-3785 JJ denotes dependent
T17146 3786-3795 NN denotes induction
T17147 3796-3798 IN denotes of
T17148 3799-3811 JJ denotes FP-activated
T17149 3812-3814 NNP denotes GR
T17150 3815-3826 NN denotes interaction
T17151 3827-3831 IN denotes with
T17152 3832-3842 JJ denotes importin-α
T17153 3843-3844 -LRB- denotes (
T17154 3844-3849 JJ denotes Imp-α
T17155 3849-3850 -RRB- denotes )
T17156 3850-3851 . denotes .
T17157 3852-3853 DT denotes A
T17158 3854-3862 JJ denotes positive
T17159 3863-3870 NN denotes control
T17160 3871-3874 IN denotes for
T17161 3875-3877 NNP denotes GR
T17162 3878-3889 NN denotes association
T17163 3890-3894 IN denotes with
T17164 3895-3903 NN denotes importin
T17165 3904-3906 VBZ denotes is
T17166 3907-3912 VBN denotes shown
T17167 3912-3913 . denotes .
T17168 3914-3928 NN denotes Quantification
T17169 3929-3931 IN denotes of
T17170 3932-3935 DT denotes the
T17171 3936-3948 NN denotes densitometry
T17172 3949-3953 NN denotes data
T17173 3954-3956 VBZ denotes is
T17174 3957-3962 VBN denotes shown
T17175 3963-3968 IN denotes below
T17176 3968-3969 . denotes .
T17177 3970-3974 DT denotes Each
T17178 3975-3978 NN denotes bar
T17179 3979-3989 VBZ denotes represents
T17180 3990-3994 JJ denotes mean
T17181 3994-3995 NN denotes ±
T17182 3995-3998 NNP denotes SEM
T17183 3999-4001 IN denotes of
T17184 4002-4004 IN denotes at
T17185 4005-4010 JJS denotes least
T17186 4011-4016 CD denotes three
T17187 4017-4028 JJ denotes independent
T17188 4029-4040 NNS denotes experiments
T17189 4040-4041 . denotes .
T17190 4042-4045 FW denotes ***
T17191 4046-4047 FW denotes p
T17192 4047-4048 FW denotes <
T17193 4048-4053 CD denotes 0.001
T17194 4054-4062 VBN denotes compared
T17195 4063-4065 TO denotes to
T17196 4066-4073 VB denotes control
T17197 4073-4074 , denotes ,
T17198 4075-4078 FW denotes ###
T17199 4079-4080 FW denotes p
T17200 4080-4081 FW denotes <
T17201 4081-4086 CD denotes 0.001
T17202 4086-4087 . denotes .
T17203 4088-4089 -LRB- denotes (
T17204 4089-4090 NNP denotes B
T17205 4090-4091 -RRB- denotes )
T17206 4092-4099 NNP denotes Western
T17207 4100-4104 NN denotes blot
T17208 4105-4113 NN denotes analysis
T17209 4114-4126 VBD denotes demonstrated
T17210 4127-4128 DT denotes a
T17211 4129-4133 NN denotes time
T17212 4133-4134 : denotes -
T17213 4135-4136 -LRB- denotes (
T17214 4136-4138 IN denotes at
T17215 4139-4141 CD denotes 10
T17216 4141-4142 NN denotes −
T17217 4142-4143 CD denotes 8
T17218 4144-4145 NNP denotes M
T17219 4146-4148 NNP denotes FP
T17220 4148-4149 -RRB- denotes )
T17221 4150-4153 CC denotes and
T17222 4154-4167 NN denotes concentration
T17223 4167-4168 : denotes -
T17224 4169-4170 -LRB- denotes (
T17225 4170-4172 IN denotes at
T17226 4173-4175 CD denotes 60
T17227 4176-4179 NN denotes min
T17228 4180-4185 IN denotes after
T17229 4186-4197 NN denotes stimulation
T17230 4197-4198 -RRB- denotes )
T17231 4199-4208 JJ denotes dependent
T17232 4209-4218 NN denotes induction
T17233 4219-4221 IN denotes of
T17234 4222-4234 JJ denotes FP-activated
T17235 4235-4237 NNP denotes GR
T17236 4238-4245 JJ denotes nuclear
T17237 4246-4259 NN denotes translocation
T17238 4260-4268 VBN denotes measured
T17239 4269-4271 IN denotes by
T17240 4272-4274 NNP denotes IP
T17241 4274-4275 . denotes .
T17242 4276-4290 NN denotes Quantification
T17243 4291-4293 IN denotes of
T17244 4294-4297 DT denotes the
T17245 4298-4310 NN denotes densitometry
T17246 4311-4315 NN denotes data
T17247 4316-4318 VBZ denotes is
T17248 4319-4324 VBN denotes shown
T17249 4325-4330 IN denotes below
T17250 4330-4331 . denotes .
T17251 4332-4336 DT denotes Each
T17252 4337-4340 NN denotes bar
T17253 4341-4351 VBZ denotes represents
T17254 4352-4356 JJ denotes mean
T17255 4356-4357 NN denotes ±
T17256 4357-4360 NNP denotes SEM
T17257 4361-4363 IN denotes of
T17258 4364-4366 IN denotes at
T17259 4367-4372 JJS denotes least
T17260 4373-4378 CD denotes three
T17261 4379-4390 JJ denotes independent
T17262 4391-4402 NNS denotes experiments
T17263 4402-4403 . denotes .
T17264 4404-4407 FW denotes ***
T17265 4407-4408 FW denotes p
T17266 4408-4409 FW denotes <
T17267 4409-4414 CD denotes 0.001
T17268 4415-4423 VBN denotes compared
T17269 4424-4426 TO denotes to
T17270 4427-4434 VB denotes control
T17271 4434-4435 . denotes .
T17272 4436-4437 -LRB- denotes (
T17273 4437-4438 $ denotes C
T17274 4438-4439 -RRB- denotes )
T17275 4440-4447 JJ denotes Western
T17276 4448-4452 NN denotes blot
T17277 4453-4461 NN denotes analysis
T17278 4462-4464 IN denotes of
T17279 4465-4471 JJ denotes HuT-78
T17280 4472-4477 NNS denotes cells
T17281 4478-4485 VBN denotes treated
T17282 4486-4490 IN denotes with
T17283 4491-4493 NNP denotes FP
T17284 4494-4497 CC denotes and
T17285 4498-4506 JJ denotes anti-CD3
T17286 4506-4507 NN denotes /
T17287 4507-4511 CD denotes CD28
T17288 4512-4526 NN denotes co-stimulation
T17289 4527-4539 VBD denotes demonstrated
T17290 4540-4541 DT denotes a
T17291 4542-4565 JJ denotes concentration-dependent
T17292 4566-4574 NN denotes decrease
T17293 4575-4577 IN denotes in
T17294 4578-4584 NNP denotes GATA-3
T17295 4585-4595 JJ denotes importin-α
T17296 4596-4607 NN denotes association
T17297 4608-4610 IN denotes at
T17298 4611-4613 CD denotes 20
T17299 4614-4617 NN denotes min
T17300 4617-4618 . denotes .
T17301 4619-4633 NN denotes Quantification
T17302 4634-4636 IN denotes of
T17303 4637-4640 DT denotes the
T17304 4641-4653 NN denotes densitometry
T17305 4654-4658 NN denotes data
T17306 4659-4661 VBZ denotes is
T17307 4662-4667 VBN denotes shown
T17308 4668-4673 IN denotes below
T17309 4673-4674 . denotes .
T17310 4675-4679 DT denotes Each
T17311 4680-4683 NN denotes bar
T17312 4684-4694 VBZ denotes represents
T17313 4695-4699 JJ denotes mean
T17314 4699-4700 NN denotes ±
T17315 4700-4703 NNP denotes SEM
T17316 4704-4706 IN denotes of
T17317 4707-4709 IN denotes at
T17318 4710-4715 JJS denotes least
T17319 4716-4721 CD denotes three
T17320 4722-4733 JJ denotes independent
T17321 4734-4745 NNS denotes experiments
T17322 4745-4746 . denotes .
T17323 4747-4750 FW denotes ###
T17324 2018-2019 FW denotes p
T17325 2019-2020 FW denotes <
T17326 2020-2025 CD denotes 0.001
T17327 2026-2034 VBN denotes compared
T17328 2035-2037 TO denotes to
T17329 2317-2324 VB denotes control
T17330 2324-2325 , denotes ,
T17331 2326-2329 FW denotes ***
T17332 2329-2330 FW denotes p
T17333 2330-2331 FW denotes <
T17334 2331-2336 CD denotes 0.001
T17335 2337-2345 VBN denotes compared
T17336 2346-2348 TO denotes to
T17337 4803-4807 JJ denotes αCD3
T17338 4807-4808 NN denotes /
T17339 4808-4823 JJ denotes CD28-stimulated
T17340 4824-4829 NNS denotes cells
T17341 4829-4830 . denotes .
T17342 4831-4832 -LRB- denotes (
T17343 4832-4833 NNP denotes D
T17344 4833-4834 -RRB- denotes )
T17345 4835-4845 JJ denotes GFP-tagged
T17346 4846-4852 NN denotes GATA-3
T17347 4853-4856 VBD denotes was
T17348 4857-4870 VBN denotes overexpressed
T17349 4871-4874 CC denotes and
T17350 4875-4880 NNS denotes cells
T17351 4881-4891 VBN denotes stimulated
T17352 4892-4893 -LRB- denotes (
T17353 4893-4894 NN denotes b
T17354 4894-4895 , denotes ,
T17355 4896-4897 NN denotes c
T17356 4897-4898 -RRB- denotes )
T17357 4899-4901 CC denotes or
T17358 4902-4905 RB denotes not
T17359 4906-4907 -LRB- denotes (
T17360 4907-4908 DT denotes a
T17361 4908-4909 -RRB- denotes )
T17362 4910-4913 IN denotes for
T17363 4914-4916 CD denotes 30
T17364 4917-4920 NN denotes min
T17365 4921-4925 IN denotes with
T17366 4926-4934 JJ denotes anti-CD3
T17367 4934-4935 NN denotes /
T17368 4935-4939 NNP denotes CD28
T17369 4939-4940 . denotes .
T17370 4941-4944 DT denotes The
T17371 4945-4951 NN denotes effect
T17372 4952-4954 IN denotes of
T17373 4955-4957 CD denotes 30
T17374 4958-4961 NN denotes min
T17375 4962-4974 NN denotes pretreatment
T17376 4975-4977 IN denotes of
T17377 4978-4983 NNS denotes cells
T17378 4984-4988 IN denotes with
T17379 4989-4991 NNP denotes FP
T17380 4992-4993 -LRB- denotes (
T17381 4993-4995 CD denotes 10
T17382 4995-4996 NN denotes −
T17383 4996-4997 CD denotes 8
T17384 4998-4999 NNP denotes M
T17385 4999-5000 , denotes ,
T17386 5001-5002 NN denotes c
T17387 5002-5003 -RRB- denotes )
T17388 5004-5006 VBZ denotes is
T17389 5007-5011 RB denotes also
T17390 5012-5017 VBN denotes shown
T17391 5017-5018 . denotes .
T17392 5019-5022 DT denotes All
T17393 5023-5027 NNS denotes data
T17394 5028-5032 VBD denotes were
T17395 5033-5041 VBN denotes analysed
T17396 5042-5044 IN denotes by
T17397 5045-5050 NNP denotes ANOVA
T17398 5051-5059 VBD denotes followed
T17399 5060-5062 IN denotes by
T17400 5063-5075 NNP denotes Newman-Keuls
T17401 5076-5085 JJS denotes post-test
T17402 5085-5086 . denotes .
T17853 6240-6251 NNP denotes Fluticasone
T17854 6252-6262 NN denotes propionate
T17855 6263-6271 VBN denotes mediated
T17856 6272-6282 NN denotes inhibition
T17857 6283-6285 IN denotes of
T17858 6286-6289 CD denotes p38
T17859 6290-6293 NNP denotes MAP
T17860 6294-6300 NN denotes kinase
T17861 6301-6316 NN denotes phosphorylation
T17862 6317-6320 CC denotes and
T17863 6321-6331 NN denotes activation
T17864 6332-6334 VBZ denotes is
T17865 6335-6345 VBN denotes associated
T17866 6346-6350 IN denotes with
T17867 6351-6352 DT denotes a
T17868 6353-6359 JJ denotes marked
T17869 6360-6375 NN denotes down-regulation
T17870 6376-6378 IN denotes of
T17871 6379-6385 JJ denotes GATA-3
T17872 6386-6392 NN denotes serine
T17873 6393-6408 NN denotes phosphorylation
T17874 6408-6409 . denotes .
T17875 6410-6411 -LRB- denotes (
T17876 6411-6412 NN denotes A
T17877 6412-6413 -RRB- denotes )
T17878 6414-6421 JJ denotes Western
T17879 6422-6426 NN denotes blot
T17880 6427-6435 NN denotes analysis
T17881 6436-6441 VBZ denotes shows
T17882 6442-6446 IN denotes that
T17883 6447-6449 NNP denotes FP
T17884 6450-6451 -LRB- denotes (
T17885 6451-6453 CD denotes 10
T17886 6453-6454 NN denotes −
T17887 6454-6455 CD denotes 8
T17888 6456-6457 NNP denotes M
T17889 6457-6458 , denotes ,
T17890 6459-6461 CD denotes 30
T17891 6462-6465 NN denotes min
T17892 6465-6466 -RRB- denotes )
T17893 6467-6476 NN denotes treatment
T17894 6477-6484 VBD denotes reduced
T17895 6485-6489 JJ denotes dual
T17896 6490-6505 NN denotes phosphorylation
T17897 6506-6507 -LRB- denotes (
T17898 6507-6520 NN denotes threonine-180
T17899 6521-6524 CC denotes and
T17900 6525-6537 NN denotes tyrosine-182
T17901 6537-6538 -RRB- denotes )
T17902 6539-6541 IN denotes of
T17903 6542-6545 CD denotes p38
T17904 6546-6550 NNP denotes MAPK
T17905 6551-6553 IN denotes in
T17906 6554-6562 JJ denotes anti-CD3
T17907 6562-6563 NN denotes /
T17908 6563-6567 CD denotes CD28
T17909 6568-6581 JJ denotes co-stimulated
T17910 6582-6588 JJ denotes HuT-78
T17911 6589-6594 NNS denotes cells
T17912 6594-6595 . denotes .
T17913 6596-6597 -LRB- denotes (
T17914 6597-6598 NNP denotes B
T17915 6598-6599 -RRB- denotes )
T17916 6600-6604 NNP denotes Time
T17917 6605-6611 NN denotes course
T17918 6612-6614 IN denotes of
T17919 6615-6618 DT denotes the
T17920 6619-6625 NN denotes effect
T17921 6626-6628 IN denotes of
T17922 6629-6631 NNP denotes FP
T17923 6632-6633 -LRB- denotes (
T17924 6633-6635 CD denotes 10
T17925 6635-6636 NN denotes −
T17926 6636-6637 CD denotes 8
T17927 6638-6639 NNP denotes M
T17928 6639-6640 -RRB- denotes )
T17929 6641-6643 IN denotes on
T17930 6644-6659 NN denotes phosphorylation
T17931 6660-6662 IN denotes of
T17932 6663-6672 VBN denotes activated
T17933 6673-6686 NN denotes transcription
T17934 6687-6693 NN denotes factor
T17935 6694-6695 CD denotes 2
T17936 6696-6697 -LRB- denotes (
T17937 6697-6702 NN denotes ATF-2
T17938 6702-6703 -RRB- denotes )
T17939 6703-6704 , denotes ,
T17940 6705-6706 DT denotes a
T17941 6707-6714 NN denotes measure
T17942 6715-6717 IN denotes of
T17943 6718-6721 CD denotes p38
T17944 6722-6726 NNP denotes MAPK
T17945 6727-6735 NN denotes activity
T17946 6735-6736 . denotes .
T17947 6737-6738 -LRB- denotes (
T17948 6738-6739 $ denotes C
T17949 6739-6740 -RRB- denotes )
T17950 6741-6751 JJ denotes FP-induced
T17951 6752-6762 NN denotes inhibition
T17952 6763-6765 IN denotes of
T17953 6766-6769 CD denotes p38
T17954 6770-6774 NNP denotes MAPK
T17955 6775-6783 NN denotes activity
T17956 6784-6786 VBZ denotes is
T17957 6787-6797 VBN denotes associated
T17958 6798-6802 IN denotes with
T17959 6803-6806 DT denotes the
T17960 6807-6815 NN denotes decrease
T17961 6816-6818 IN denotes of
T17962 6819-6827 JJ denotes anti-CD3
T17963 6827-6828 NN denotes /
T17964 6828-6832 CD denotes CD28
T17965 6833-6847 NN denotes co-stimulation
T17966 6848-6855 VBD denotes induced
T17967 6856-6862 JJ denotes serine
T17968 6863-6878 NN denotes phosphorylation
T17969 6879-6880 -LRB- denotes (
T17970 6880-6885 NN denotes P-Ser
T17971 6885-6886 -RRB- denotes )
T17972 6887-6889 IN denotes of
T17973 6890-6896 NN denotes GATA-3
T17974 6896-6897 . denotes .
T17975 6898-6901 IN denotes For
T17976 6902-6903 -LRB- denotes (
T17977 6903-6904 DT denotes A
T17978 6905-6906 NNP denotes C
T17979 6906-6907 -RRB- denotes )
T17980 6907-6908 , denotes ,
T17981 6909-6923 NN denotes quantification
T17982 6924-6926 IN denotes of
T17983 6927-6930 DT denotes the
T17984 6931-6943 NN denotes densitometry
T17985 6944-6948 NN denotes data
T17986 6949-6951 VBZ denotes is
T17987 6952-6956 RB denotes also
T17988 6957-6962 VBN denotes shown
T17989 6962-6963 . denotes .
T17990 6964-6968 DT denotes Each
T17991 6969-6972 NN denotes bar
T17992 6973-6983 VBZ denotes represents
T17993 6984-6988 JJ denotes mean
T17994 6988-6989 NN denotes ±
T17995 6989-6992 NNP denotes SEM
T17996 6993-6995 IN denotes of
T17997 6996-6998 IN denotes at
T17998 6999-7004 JJS denotes least
T17999 7005-7010 CD denotes three
T18000 7011-7022 JJ denotes independent
T18001 7023-7034 NNS denotes experiments
T18002 7034-7035 . denotes .
T18003 7036-7039 FW denotes ###
T18004 2018-2019 FW denotes p
T18005 2019-2020 FW denotes <
T18006 2020-2025 CD denotes 0.001
T18007 2026-2034 VBN denotes compared
T18008 2035-2037 TO denotes to
T18009 2317-2324 VB denotes control
T18010 2324-2325 , denotes ,
T18011 2326-2329 FW denotes ***
T18012 2329-2330 FW denotes p
T18013 2330-2331 FW denotes <
T18014 2331-2336 CD denotes 0.001
T18015 2337-2345 VBN denotes compared
T18016 2346-2348 TO denotes to
T18017 4803-4807 JJ denotes αCD3
T18018 4807-4808 NN denotes /
T18019 4808-4823 JJ denotes CD28-stimulated
T18020 4824-4829 NNS denotes cells
T18021 4829-4830 . denotes .
T18022 4831-4832 -LRB- denotes (
T18023 4832-4833 NNP denotes D
T18024 4833-4834 -RRB- denotes )
T18025 7124-7126 NNP denotes FP
T18026 7127-7134 VBD denotes induced
T18027 7135-7140 NNP denotes MKP-1
T18028 7141-7145 NNP denotes mRNA
T18029 7146-7148 IN denotes in
T18030 7149-7150 DT denotes a
T18031 7151-7174 JJ denotes concentration-dependent
T18032 7175-7181 NN denotes manner
T18033 7181-7182 . denotes .
T18034 7183-7186 DT denotes All
T18035 7187-7194 NNS denotes results
T18036 7195-7198 VBP denotes are
T18037 7199-7213 NN denotes representative
T18038 7214-7216 IN denotes of
T18039 7217-7219 IN denotes at
T18040 7220-7225 JJS denotes least
T18041 7226-7231 CD denotes three
T18042 7232-7243 JJ denotes independent
T18043 7244-7255 NNS denotes experiments
T18044 7256-7259 CC denotes and
T18045 7260-7265 WRB denotes where
T18046 7266-7277 JJ denotes appropriate
T18047 7278-7287 VBN denotes expressed
T18048 7288-7290 IN denotes as
T18049 7291-7296 NNS denotes means
T18050 7296-7297 VBP denotes ±
T18051 7297-7300 NNP denotes SEM
T18052 7300-7301 , denotes ,
T18053 7302-7303 SYM denotes *
T18054 7303-7304 FW denotes p
T18055 7304-7305 FW denotes <
T18056 7305-7309 CD denotes 0.05
T18057 7309-7310 . denotes .
T18058 7311-7312 -LRB- denotes (
T18059 7312-7313 NNP denotes E
T18060 7313-7314 -RRB- denotes )
T18061 7315-7317 NNP denotes FP
T18062 7318-7325 VBZ denotes induces
T18063 7326-7331 NNP denotes MKP-1
T18064 7332-7336 NNP denotes mRNA
T18065 7337-7339 IN denotes in
T18066 7340-7341 DT denotes a
T18067 7342-7356 JJ denotes time-dependent
T18068 7357-7363 NN denotes manner
T18069 7363-7364 . denotes .
T18070 7365-7372 NNS denotes Results
T18071 7373-7376 VBP denotes are
T18072 7377-7391 NN denotes representative
T18073 7392-7394 IN denotes of
T18074 7395-7398 CD denotes two
T18075 7399-7410 JJ denotes independent
T18076 7411-7422 NNS denotes experiments
T18077 7422-7423 . denotes .
T18078 7424-7427 DT denotes All
T18079 7428-7432 NNS denotes data
T18080 7433-7439 IN denotes except
T18081 7440-7441 -LRB- denotes (
T18082 7441-7442 NNP denotes E
T18083 7442-7443 -RRB- denotes )
T18084 7444-7448 VBD denotes were
T18085 7449-7457 VBN denotes analysed
T18086 7458-7460 IN denotes by
T18087 7461-7466 NNP denotes ANOVA
T18088 7467-7475 VBD denotes followed
T18089 7476-7478 IN denotes by
T18090 7479-7491 NNP denotes Newman-Keuls
T18091 7492-7501 JJS denotes post-test
T18092 7501-7502 . denotes .
T18334 8290-8301 NNP denotes Fluticasone
T18335 8302-8312 NN denotes propionate
T18336 8313-8321 VBZ denotes competes
T18337 8322-8326 IN denotes with
T18338 8327-8341 NN denotes phospho-GATA-3
T18339 8342-8345 IN denotes for
T18340 8346-8356 NN denotes importin-α
T18341 8356-8357 . denotes .
T18342 8358-8359 -LRB- denotes (
T18343 8359-8360 NNP denotes A
T18344 8360-8361 -RRB- denotes )
T18345 8362-8371 JJ denotes schematic
T18346 8372-8386 NN denotes representation
T18347 8387-8389 IN denotes of
T18348 8390-8393 DT denotes the
T18349 8394-8396 IN denotes in
T18350 8397-8402 NN denotes vitro
T18351 8403-8410 JJ denotes binding
T18352 8411-8422 NN denotes competition
T18353 8423-8428 NN denotes assay
T18354 8428-8429 . denotes .
T18355 8430-8431 -LRB- denotes (
T18356 8431-8432 NNP denotes B
T18357 8432-8433 -RRB- denotes )
T18358 8434-8436 NNP denotes GR
T18359 8437-8445 VBD denotes isolated
T18360 8446-8450 IN denotes from
T18361 8451-8453 NNP denotes FP
T18362 8454-8455 -LRB- denotes (
T18363 8455-8457 CD denotes 10
T18364 8457-8458 NN denotes −
T18365 8458-8459 CD denotes 8
T18366 8460-8461 NNP denotes M
T18367 8461-8462 -RRB- denotes )
T18368 8463-8473 VBD denotes stimulated
T18369 8474-8479 NNS denotes cells
T18370 8480-8488 VBZ denotes enhances
T18371 8489-8491 NNP denotes GR
T18372 8492-8502 JJ denotes importin-α
T18373 8503-8510 JJ denotes binding
T18374 8511-8513 IN denotes in
T18375 8514-8517 DT denotes the
T18376 8518-8526 NN denotes presence
T18377 8527-8528 -LRB- denotes (
T18378 8528-8529 FW denotes •
T18379 8529-8530 -RRB- denotes )
T18380 8531-8534 CC denotes and
T18381 8535-8542 NN denotes absence
T18382 8543-8544 -LRB- denotes (
T18383 8544-8545 FW denotes ▪
T18384 8545-8546 -RRB- denotes )
T18385 8547-8549 IN denotes of
T18386 8550-8559 VBN denotes activated
T18387 8560-8566 NNP denotes GATA-3
T18388 8566-8567 . denotes .
T18389 8568-8569 SYM denotes *
T18390 8570-8571 NN denotes p
T18391 8571-8572 NN denotes <
T18392 8572-8576 CD denotes 0.05
T18393 8577-8585 VBN denotes compared
T18394 8586-8588 TO denotes to
T18395 8589-8591 DT denotes no
T18396 8592-8601 VBN denotes activated
T18397 8602-8604 NNP denotes GR
T18398 8604-8605 . denotes .
T18399 8606-8607 -LRB- denotes (
T18400 8607-8608 $ denotes C
T18401 8608-8609 -RRB- denotes )
T18402 8610-8616 JJ denotes GATA-3
T18403 8617-8625 VBN denotes isolated
T18404 8626-8630 IN denotes from
T18405 8631-8639 JJ denotes anti-CD3
T18406 8639-8640 NN denotes /
T18407 8640-8644 CD denotes CD28
T18408 8645-8655 VBD denotes stimulated
T18409 8656-8661 NNS denotes cells
T18410 8662-8666 VBZ denotes does
T18411 8667-8670 RB denotes not
T18412 8671-8680 VB denotes attenuate
T18413 8681-8683 NNP denotes GR
T18414 8684-8694 JJ denotes importin-α
T18415 8695-8706 NN denotes association
T18416 8706-8707 . denotes .
T18417 8708-8709 SYM denotes *
T18418 8709-8710 NN denotes p
T18419 8710-8711 NN denotes <
T18420 8711-8715 CD denotes 0.05
T18421 8716-8724 VBN denotes compared
T18422 8725-8727 TO denotes to
T18423 8728-8735 VB denotes control
T18424 8735-8736 . denotes .
T18425 8737-8738 -LRB- denotes (
T18426 8738-8739 NNP denotes D
T18427 8739-8740 -RRB- denotes )
T18428 8741-8750 NNP denotes Activated
T18429 8751-8753 NNP denotes GR
T18430 8754-8760 VBZ denotes blocks
T18431 8761-8764 DT denotes the
T18432 8765-8772 NN denotes ability
T18433 8773-8775 IN denotes of
T18434 8776-8784 JJ denotes purified
T18435 8785-8799 JJ denotes phospho-GATA-3
T18436 8800-8808 VBN denotes isolated
T18437 8809-8813 IN denotes from
T18438 8814-8822 JJ denotes anti-CD3
T18439 8822-8823 NN denotes /
T18440 8823-8827 CD denotes CD28
T18441 8828-8838 VBD denotes stimulated
T18442 8839-8844 NNS denotes cells
T18443 8845-8856 VBG denotes interacting
T18444 8857-8861 IN denotes with
T18445 8862-8873 JJ denotes immobilised
T18446 8874-8884 NN denotes importin-α
T18447 8885-8887 IN denotes in
T18448 8888-8890 DT denotes an
T18449 8891-8893 IN denotes in
T18450 8894-8899 NN denotes vitro
T18451 8900-8907 JJ denotes binding
T18452 8908-8913 NN denotes assay
T18453 8913-8914 . denotes .
T18454 8915-8916 SYM denotes *
T18455 8916-8917 NN denotes p
T18456 8917-8918 NN denotes <
T18457 8918-8922 CD denotes 0.05
T18458 8923-8931 VBN denotes compared
T18459 8932-8934 TO denotes to
T18460 8935-8941 JJ denotes GATA-3
T18461 8942-8950 VBN denotes isolated
T18462 8951-8955 IN denotes from
T18463 8956-8968 JJ denotes unstimulated
T18464 8969-8974 NNS denotes cells
T18465 8974-8975 . denotes .
T18466 8976-8979 JJ denotes # p
T18467 8979-8980 NN denotes <
T18468 8980-8984 CD denotes 0.05
T18469 8985-8993 VBN denotes compared
T18470 8994-8996 TO denotes to
T18471 8997-9007 VBN denotes stimulated
T18472 9008-9023 JJ denotes GATA-3-importin
T18473 9024-9031 JJ denotes binding
T18474 9031-9032 . denotes .
T18475 9033-9034 -LRB- denotes (
T18476 9034-9035 NNP denotes E
T18477 9035-9036 -RRB- denotes )
T18478 9037-9040 DT denotes The
T18479 9041-9047 NN denotes effect
T18480 9048-9050 IN denotes of
T18481 9051-9060 VBN denotes activated
T18482 9061-9062 -LRB- denotes (
T18483 9062-9063 NN denotes •
T18484 9063-9064 -RRB- denotes )
T18485 9065-9071 CC denotes versus
T18486 9072-9084 JJ denotes unstimulated
T18487 9085-9086 -LRB- denotes (
T18488 9086-9087 NN denotes ○
T18489 9087-9088 -RRB- denotes )
T18490 9089-9091 NN denotes GR
T18491 9092-9094 IN denotes on
T18492 9095-9106 NN denotes attenuation
T18493 9107-9109 IN denotes of
T18494 9110-9116 NNP denotes GATA-3
T18495 9117-9127 JJ denotes importin-α
T18496 9128-9139 NN denotes association
T18497 9140-9143 VBD denotes was
T18498 9144-9167 JJ denotes concentration-dependent
T18499 9167-9168 . denotes .
T18500 9169-9170 SYM denotes *
T18501 9170-9171 NN denotes p
T18502 9171-9172 NN denotes <
T18503 9172-9176 CD denotes 0.05
T18504 9176-9177 , denotes ,
T18505 9178-9180 SYM denotes **
T18506 9180-9181 FW denotes p
T18507 9181-9182 FW denotes <
T18508 9182-9186 CD denotes 0.01
T18509 9187-9194 IN denotes between
T18510 9195-9201 NNS denotes groups
T18511 9201-9202 . denotes .
T18512 9203-9206 DT denotes All
T18513 9207-9214 NNS denotes results
T18514 9215-9218 VBP denotes are
T18515 9219-9228 VBN denotes expressed
T18516 9229-9231 IN denotes as
T18517 9232-9236 JJ denotes mean
T18518 9236-9237 NN denotes ±
T18519 9237-9240 NNP denotes SEM
T18520 9241-9243 IN denotes of
T18521 9244-9249 CD denotes three
T18522 9250-9261 JJ denotes independent
T18523 9262-9273 NNS denotes experiments
T18524 9274-9277 CC denotes and
T18525 9278-9286 VBN denotes analysed
T18526 9287-9289 IN denotes by
T18527 9290-9295 NNP denotes ANOVA
T18528 9296-9304 VBD denotes followed
T18529 9305-9307 IN denotes by
T18530 9308-9320 NNP denotes Newman-Keuls
T18531 9321-9330 JJS denotes post-test
T18532 9330-9331 . denotes .
T18930 10099-10110 NNP denotes Fluticasone
T18931 10111-10121 NN denotes propionate
T18932 10122-10126 VBZ denotes does
T18933 10127-10130 RB denotes not
T18934 10131-10137 VB denotes affect
T18935 10138-10144 JJ denotes GATA-3
T18936 10145-10152 JJ denotes nuclear
T18937 10153-10159 NN denotes export
T18938 10159-10160 . denotes .
T18939 10161-10162 -LRB- denotes (
T18940 10162-10163 NN denotes A
T18941 10163-10164 -RRB- denotes )
T18942 10165-10172 JJ denotes Western
T18943 10173-10177 NN denotes blot
T18944 10178-10186 NN denotes analysis
T18945 10187-10194 VBG denotes showing
T18946 10195-10199 IN denotes that
T18947 10200-10203 DT denotes the
T18948 10204-10211 JJ denotes nuclear
T18949 10212-10218 NN denotes export
T18950 10219-10228 NN denotes inhibitor
T18951 10229-10239 NN denotes leptomycin
T18952 10240-10241 NNP denotes B
T18953 10242-10243 -LRB- denotes (
T18954 10243-10244 CD denotes 2
T18955 10245-10247 NNP denotes nM
T18956 10247-10248 -RRB- denotes )
T18957 10249-10253 VBZ denotes does
T18958 10254-10257 RB denotes not
T18959 10258-10264 VB denotes affect
T18960 10265-10268 DT denotes the
T18961 10269-10276 NN denotes ability
T18962 10277-10279 IN denotes of
T18963 10280-10282 NNP denotes FP
T18964 10283-10284 -LRB- denotes (
T18965 10284-10286 CD denotes 10
T18966 10286-10287 NN denotes −
T18967 10287-10288 CD denotes 8
T18968 10289-10290 NNP denotes M
T18969 10290-10291 -RRB- denotes )
T18970 10292-10294 TO denotes to
T18971 10295-10302 VB denotes prevent
T18972 10303-10311 JJ denotes anti-CD3
T18973 10311-10312 NN denotes /
T18974 10312-10316 CD denotes CD28
T18975 10317-10327 VBD denotes stimulated
T18976 10328-10334 JJ denotes GATA-3
T18977 10335-10342 JJ denotes nuclear
T18978 10343-10355 NN denotes localization
T18979 10356-10364 VBN denotes measured
T18980 10365-10367 IN denotes at
T18981 10368-10370 CD denotes 60
T18982 10371-10374 NN denotes min
T18983 10374-10375 . denotes .
T18984 10376-10379 FW denotes ***
T18985 10379-10380 FW denotes p
T18986 10380-10381 FW denotes <
T18987 10381-10386 CD denotes 0.001
T18988 10387-10395 VBN denotes compared
T18989 10396-10398 TO denotes to
T18990 10399-10411 JJ denotes unstimulated
T18991 10412-10417 NNS denotes cells
T18992 10417-10418 , denotes ,
T18993 10419-10422 FW denotes ###
T18994 2329-2330 FW denotes p
T18995 2330-2331 FW denotes <
T18996 2331-2336 CD denotes 0.001
T18997 2337-2345 VBN denotes compared
T18998 2346-2348 TO denotes to
T18999 2349-2357 JJ denotes anti-CD3
T19000 2357-2358 NN denotes /
T19001 2358-2362 CD denotes CD28
T19002 2363-2373 VBD denotes stimulated
T19003 10468-10473 NNS denotes cells
T19004 10473-10474 . denotes .
T19005 10475-10476 -LRB- denotes (
T19006 10476-10477 NNP denotes B
T19007 10477-10478 -RRB- denotes )
T19008 10479-10486 NNP denotes Western
T19009 10487-10491 NN denotes blot
T19010 10492-10500 NN denotes analysis
T19011 10501-10508 VBG denotes showing
T19012 10509-10513 IN denotes that
T19013 10514-10516 NNP denotes FP
T19014 10517-10518 -LRB- denotes (
T19015 10518-10520 CD denotes 10
T19016 10520-10521 NN denotes −
T19017 10521-10522 CD denotes 8
T19018 10523-10524 NNP denotes M
T19019 10524-10525 -RRB- denotes )
T19020 10526-10530 VBZ denotes does
T19021 10531-10534 RB denotes not
T19022 10535-10541 VB denotes affect
T19023 10542-10552 JJ denotes whole-cell
T19024 10553-10559 JJ denotes GATA-3
T19025 10560-10571 NN denotes degradation
T19026 10572-10576 IN denotes over
T19027 10577-10579 CD denotes 17
T19028 10580-10582 NN denotes h.
T19029 10583-10584 -LRB- denotes (
T19030 10584-10585 NNP denotes C
T19031 10585-10586 -RRB- denotes )
T19032 10587-10597 JJ denotes GFP-tagged
T19033 10598-10604 NN denotes GATA-3
T19034 10605-10607 VBZ denotes is
T19035 10608-10621 VBN denotes overexpressed
T19036 10622-10625 CC denotes and
T19037 10626-10631 NNS denotes cells
T19038 10632-10642 VBN denotes stimulated
T19039 10643-10644 -LRB- denotes (
T19040 10644-10645 NN denotes b
T19041 10646-10647 NN denotes j
T19042 10647-10648 -RRB- denotes )
T19043 10649-10651 CC denotes or
T19044 10652-10655 RB denotes not
T19045 10656-10657 -LRB- denotes (
T19046 10657-10658 DT denotes a
T19047 10658-10659 -RRB- denotes )
T19048 10660-10664 IN denotes with
T19049 10665-10673 JJ denotes anti-CD3
T19050 10673-10674 NN denotes /
T19051 10674-10678 NNP denotes CD28
T19052 10678-10679 . denotes .
T19053 10680-10683 DT denotes The
T19054 10684-10690 NN denotes effect
T19055 10691-10693 IN denotes of
T19056 10694-10702 VBG denotes treating
T19057 10703-10708 NNS denotes cells
T19058 10709-10713 IN denotes with
T19059 10714-10716 NNP denotes FP
T19060 10717-10718 -LRB- denotes (
T19061 10718-10720 CD denotes 10
T19062 10720-10721 NN denotes −
T19063 10721-10722 CD denotes 8
T19064 10723-10724 NNP denotes M
T19065 10724-10725 , denotes ,
T19066 10726-10727 SYM denotes f
T19067 10728-10729 NN denotes j
T19068 10729-10730 -RRB- denotes )
T19069 10731-10736 IN denotes after
T19070 10737-10739 CD denotes 30
T19071 10740-10743 NN denotes min
T19072 10744-10755 NN denotes stimulation
T19073 10756-10760 IN denotes with
T19074 10761-10769 JJ denotes anti-CD3
T19075 10769-10770 NN denotes /
T19076 10770-10774 NNP denotes CD28
T19077 10775-10777 VBZ denotes is
T19078 10778-10782 RB denotes also
T19079 10783-10788 VBN denotes shown
T19080 10788-10789 . denotes .
T19081 10790-10791 -LRB- denotes (
T19082 10791-10792 NNP denotes D
T19083 10792-10793 -RRB- denotes )
T19084 10794-10796 NNP denotes FP
T19085 10797-10798 -LRB- denotes (
T19086 10798-10800 CD denotes 10
T19087 10800-10801 NN denotes −
T19088 10801-10802 CD denotes 8
T19089 10803-10804 NNP denotes M
T19090 10804-10805 -RRB- denotes )
T19091 10806-10810 VBZ denotes does
T19092 10811-10814 RB denotes not
T19093 10815-10822 VB denotes prevent
T19094 10823-10831 JJ denotes anti-CD3
T19095 10831-10832 NN denotes /
T19096 10832-10836 CD denotes CD28
T19097 10837-10847 VBD denotes stimulated
T19098 10848-10851 CD denotes p65
T19099 10852-10859 JJ denotes nuclear
T19100 10860-10873 NN denotes translocation
T19101 10874-10876 IN denotes at
T19102 10877-10879 CD denotes 60
T19103 10880-10883 NN denotes min
T19104 10884-10889 IN denotes after
T19105 10890-10901 NN denotes stimulation
T19106 10901-10902 . denotes .
T19107 10903-10905 SYM denotes **
T19108 10905-10906 FW denotes p
T19109 10906-10907 FW denotes <
T19110 10907-10911 CD denotes 0.01
T19111 10912-10920 VBN denotes compared
T19112 10921-10923 TO denotes to
T19113 10924-10936 JJ denotes unstimulated
T19114 10937-10942 NNS denotes cells
T19115 10942-10943 . denotes .
T19116 10944-10947 DT denotes All
T19117 10948-10955 NNS denotes results
T19118 10956-10959 VBP denotes are
T19119 10960-10974 NN denotes representative
T19120 10975-10977 IN denotes of
T19121 10978-10980 IN denotes at
T19122 10981-10986 JJS denotes least
T19123 10987-10991 CD denotes four
T19124 10992-11003 JJ denotes independent
T19125 11004-11015 NNS denotes experiments
T19126 11016-11019 CC denotes and
T19127 11020-11023 VBP denotes are
T19128 11024-11029 VBN denotes shown
T19129 11030-11032 IN denotes as
T19130 11033-11037 JJ denotes mean
T19131 11037-11038 NN denotes ±
T19132 11038-11041 NNP denotes SEM
T19133 11041-11042 . denotes .
T19134 11043-11050 NNS denotes Results
T19135 11051-11055 VBD denotes were
T19136 11056-11064 VBN denotes analysed
T19137 11065-11067 IN denotes by
T19138 11068-11073 NNP denotes ANOVA
T19139 11074-11082 VBD denotes followed
T19140 11083-11085 IN denotes by
T19141 11086-11098 NNP denotes Newman-Keuls
T19142 11099-11103 NN denotes test
T19143 11103-11104 . denotes .
T19430 11626-11637 NNP denotes Fluticasone
T19431 11638-11648 NN denotes propionate
T19432 11649-11656 VBZ denotes impairs
T19433 11657-11663 JJ denotes GATA-3
T19434 11664-11675 NN denotes interaction
T19435 11676-11680 IN denotes with
T19436 11681-11691 JJ denotes importin-α
T19437 11692-11695 CC denotes and
T19438 11696-11702 JJ denotes GATA-3
T19439 11703-11710 JJ denotes nuclear
T19440 11711-11723 NN denotes localization
T19441 11724-11726 IN denotes in
T19442 11727-11731 NN denotes vivo
T19443 11732-11735 CC denotes and
T19444 11736-11738 FW denotes ex
T19445 11739-11743 FW denotes vivo
T19446 11743-11744 . denotes .
T19447 11745-11746 -LRB- denotes (
T19448 11746-11747 DT denotes A
T19449 11748-11751 CC denotes and
T19450 11752-11753 NNP denotes B
T19451 11753-11754 -RRB- denotes )
T19452 11755-11777 NN denotes Co-immunoprecipitation
T19453 11778-11786 NN denotes analysis
T19454 11787-11789 IN denotes of
T19455 11790-11795 NNS denotes PBMCs
T19456 11796-11800 IN denotes from
T19457 11801-11814 JJ denotes steroid-naïve
T19458 11815-11821 NN denotes asthma
T19459 11822-11830 NNS denotes patients
T19460 11831-11838 VBN denotes treated
T19461 11839-11843 IN denotes with
T19462 11844-11846 NNP denotes FP
T19463 11847-11849 IN denotes in
T19464 11850-11855 NN denotes vitro
T19465 11856-11868 VBD denotes demonstrated
T19466 11869-11877 VBN denotes impaired
T19467 11878-11889 NN denotes interaction
T19468 11890-11897 IN denotes between
T19469 11898-11904 NNP denotes GATA-3
T19470 11905-11908 CC denotes and
T19471 11909-11919 JJ denotes importin-α
T19472 11920-11928 VBN denotes measured
T19473 11929-11931 IN denotes at
T19474 11932-11934 CD denotes 60
T19475 11935-11938 NN denotes min
T19476 11938-11939 . denotes .
T19477 11940-11944 DT denotes Each
T19478 11945-11948 NN denotes bar
T19479 11949-11959 VBZ denotes represents
T19480 11960-11963 DT denotes the
T19481 11964-11968 JJ denotes mean
T19482 11968-11969 NN denotes ±
T19483 11969-11972 NNP denotes SEM
T19484 11973-11975 IN denotes of
T19485 11976-11978 IN denotes at
T19486 11979-11984 JJS denotes least
T19487 11985-11990 CD denotes three
T19488 11991-12002 JJ denotes independent
T19489 12003-12014 NNS denotes experiments
T19490 12014-12015 : denotes ;
T19491 12016-12019 FW denotes ***
T19492 12020-12021 FW denotes p
T19493 12021-12022 FW denotes <
T19494 12022-12027 CD denotes 0.001
T19495 12028-12036 VBN denotes compared
T19496 12037-12041 IN denotes with
T19497 12042-12049 NN denotes control
T19498 12050-12052 IN denotes as
T19499 12053-12063 VBN denotes determined
T19500 12064-12066 IN denotes by
T19501 12067-12085 NNP denotes ANOVA/Newman-Keuls
T19502 12086-12094 NN denotes analysis
T19503 12094-12095 . denotes .
T19504 12096-12097 -LRB- denotes (
T19505 12097-12098 NNP denotes C
T19506 12099-12102 CC denotes and
T19507 12103-12104 NNP denotes D
T19508 12104-12105 -RRB- denotes )
T19509 12106-12128 NN denotes Co-immunoprecipitation
T19510 12129-12137 NNS denotes analyses
T19511 12138-12140 IN denotes of
T19512 12141-12146 NNS denotes PBMCs
T19513 12147-12151 IN denotes from
T19514 12152-12165 JJ denotes steroid-naïve
T19515 12166-12172 NN denotes asthma
T19516 12173-12181 NNS denotes patients
T19517 12182-12189 VBN denotes treated
T19518 12190-12194 IN denotes with
T19519 12195-12202 JJ denotes inhaled
T19520 12203-12205 NNP denotes FP
T19521 12206-12207 -LRB- denotes (
T19522 12207-12210 CD denotes 500
T19523 12211-12213 NN denotes µg
T19524 12214-12217 IN denotes via
T19525 12218-12219 DT denotes a
T19526 12220-12226 NN denotes spacer
T19527 12226-12227 -RRB- denotes )
T19528 12228-12230 IN denotes in
T19529 12231-12235 NN denotes vivo
T19530 12236-12248 VBD denotes demonstrated
T19531 12249-12258 VBN denotes decreased
T19532 12259-12270 NN denotes association
T19533 12271-12278 IN denotes between
T19534 12279-12285 NNP denotes GATA-3
T19535 12286-12289 CC denotes and
T19536 12290-12300 JJ denotes importin-α
T19537 12300-12301 . denotes .
T19538 12302-12305 DT denotes The
T19539 12306-12316 JJ denotes individual
T19540 12317-12323 NNS denotes values
T19541 12324-12327 IN denotes for
T19542 12328-12332 DT denotes each
T19543 12333-12342 NN denotes treatment
T19544 12343-12346 VBP denotes are
T19545 12347-12356 VBN denotes presented
T19546 12357-12368 RB denotes graphically
T19547 12368-12369 . denotes .
T19548 12370-12371 -LRB- denotes (
T19549 12371-12372 NNP denotes E
T19550 12372-12373 -RRB- denotes )
T19551 12374-12388 NNP denotes Representative
T19552 12389-12396 NNP denotes Western
T19553 12397-12401 NN denotes blot
T19554 12402-12409 VBG denotes showing
T19555 12410-12414 IN denotes that
T19556 12415-12425 JJ denotes importin-α
T19557 12426-12436 NN denotes expression
T19558 12437-12440 VBD denotes was
T19559 12441-12451 JJ denotes unaffected
T19560 12452-12454 IN denotes by
T19561 12455-12465 NN denotes inhalation
T19562 12466-12468 IN denotes of
T19563 12469-12471 NNP denotes FP
T19564 12471-12472 . denotes .
T19565 12473-12477 NNP denotes Blot
T19566 12478-12480 VBZ denotes is
T19567 12481-12495 NN denotes representative
T19568 12496-12498 IN denotes of
T19569 12499-12503 NNS denotes gels
T19570 12504-12508 IN denotes from
T19571 12509-12514 CD denotes three
T19572 12515-12527 NNS denotes participants
T19573 12527-12528 . denotes .
T19983 14813-14820 VBN denotes Inhaled
T19984 14821-14832 NN denotes fluticasone
T19985 14833-14843 NN denotes propionate
T19986 14844-14851 VBZ denotes impairs
T19987 14852-14858 JJ denotes GATA-3
T19988 14859-14866 JJ denotes nuclear
T19989 14867-14879 NN denotes localization
T19990 14880-14882 IN denotes in
T19991 14883-14888 NNP denotes PBMCs
T19992 14888-14889 . denotes .
T19993 14890-14891 -LRB- denotes (
T19994 14891-14892 NNP denotes A
T19995 14892-14893 -RRB- denotes )
T19996 14894-14908 NNP denotes Representative
T19997 14909-14928 NN denotes immunocytochemistry
T19998 14929-14931 IN denotes of
T19999 14932-14939 VBG denotes showing
T20000 14940-14943 DT denotes the
T20001 14944-14950 NN denotes effect
T20002 14951-14953 IN denotes of
T20003 14954-14961 JJ denotes inhaled
T20004 14962-14964 NNP denotes FP
T20005 14965-14966 -LRB- denotes (
T20006 14966-14969 CD denotes 500
T20007 14970-14972 NN denotes µg
T20008 14972-14973 -RRB- denotes )
T20009 14974-14976 IN denotes on
T20010 14977-14979 NNP denotes GR
T20011 14980-14983 CC denotes and
T20012 14984-14990 NNP denotes GATA-3
T20013 14991-14998 JJ denotes nuclear
T20014 14999-15011 NN denotes localisation
T20015 15011-15012 . denotes .
T20016 15013-15014 -LRB- denotes (
T20017 15014-15015 NNP denotes B
T20018 15015-15016 -RRB- denotes )
T20019 15017-15024 NNP denotes Nuclear
T20020 15025-15031 NNP denotes GATA-3
T20021 15032-15048 NN denotes immunoreactivity
T20022 15049-15051 IN denotes in
T20023 15052-15057 NNS denotes PBMCs
T20024 15058-15062 IN denotes from
T20025 15063-15068 CD denotes seven
T20026 15069-15082 JJ denotes steroid-naïve
T20027 15083-15089 NN denotes asthma
T20028 15090-15098 NNS denotes patients
T20029 15099-15100 CD denotes 2
T20030 15101-15102 NN denotes h
T20031 15103-15112 VBG denotes following
T20032 15113-15120 JJ denotes inhaled
T20033 15121-15123 NNP denotes FP
T20034 15124-15133 NN denotes treatment
T20035 15134-15135 -LRB- denotes (
T20036 15135-15138 CD denotes 100
T20037 15139-15141 CC denotes or
T20038 15142-15145 CD denotes 500
T20039 15146-15148 NN denotes µg
T20040 15149-15152 IN denotes via
T20041 15153-15159 NN denotes spacer
T20042 15159-15160 -RRB- denotes )
T20043 15160-15161 . denotes .
T20044 15162-15165 DT denotes The
T20045 15166-15172 NN denotes median
T20046 15173-15176 CC denotes and
T20047 15177-15190 JJ denotes interquartile
T20048 15191-15197 NNS denotes ranges
T20049 15198-15201 IN denotes for
T20050 15202-15206 DT denotes each
T20051 15207-15216 NN denotes treatment
T20052 15217-15220 VBP denotes are
T20053 15221-15230 VBN denotes presented
T20054 15231-15233 IN denotes as
T20055 15234-15235 DT denotes a
T20056 15236-15252 NNS denotes box-and-whiskers
T20057 15253-15257 NN denotes plot
T20058 15258-15259 -LRB- denotes (
T20059 15259-15260 FW denotes n
T20060 15261-15262 SYM denotes =
T20061 15263-15264 CD denotes 7
T20062 15264-15265 -RRB- denotes )
T20063 15265-15266 : denotes ;
T20064 15267-15268 SYM denotes *
T20065 15269-15270 NN denotes p
T20066 15270-15271 NN denotes <
T20067 15271-15275 CD denotes 0.05
T20068 15276-15284 NNP denotes Wilcoxon
T20069 15284-15286 POS denotes 's
T20070 15287-15291 NN denotes rank
T20071 15292-15296 NN denotes test
T20072 15297-15305 VBN denotes compared
T20073 15306-15310 IN denotes with
T20074 15311-15318 NN denotes placebo
T20075 15318-15319 . denotes .
T20076 15320-15321 -LRB- denotes (
T20077 15321-15322 NNP denotes C
T20078 15322-15323 -RRB- denotes )
T20079 15324-15338 NNP denotes Immunoblotting
T20080 15339-15347 NNS denotes analyses
T20081 15348-15350 IN denotes of
T20082 15351-15356 NNP denotes PBMCs
T20083 15357-15369 VBD denotes demonstrated
T20084 15370-15371 DT denotes a
T20085 15372-15386 JJ denotes time-dependent
T20086 15387-15395 NN denotes decrease
T20087 15396-15398 IN denotes in
T20088 15399-15406 JJ denotes nuclear
T20089 15407-15417 NN denotes expression
T20090 15418-15420 IN denotes of
T20091 15421-15427 NNP denotes GATA-3
T20092 15427-15428 , denotes ,
T20093 15429-15432 CC denotes and
T20094 15433-15442 VBD denotes increased
T20095 15443-15454 JJ denotes cytoplasmic
T20096 15455-15461 JJ denotes GATA-3
T20097 15462-15472 NN denotes expression
T20098 15473-15478 IN denotes after
T20099 15479-15489 NN denotes inhalation
T20100 15490-15492 IN denotes of
T20101 15493-15495 NNP denotes FP
T20102 15495-15496 . denotes .
T20103 15497-15498 -LRB- denotes (
T20104 15498-15499 NNP denotes D
T20105 15499-15500 -RRB- denotes )
T20106 15501-15515 NNP denotes Immunoblotting
T20107 15516-15524 NNS denotes analyses
T20108 15525-15527 IN denotes of
T20109 15528-15533 NNP denotes PBMCs
T20110 15534-15546 VBD denotes demonstrated
T20111 15547-15548 DT denotes a
T20112 15549-15563 JJ denotes dose-dependent
T20113 15564-15572 NN denotes decrease
T20114 15573-15575 IN denotes in
T20115 15576-15583 JJ denotes nuclear
T20116 15584-15594 NN denotes expression
T20117 15595-15597 IN denotes of
T20118 15598-15604 NNP denotes GATA-3
T20119 15604-15605 , denotes ,
T20120 15606-15609 CC denotes and
T20121 15610-15619 VBD denotes increased
T20122 15620-15631 JJ denotes cytoplasmic
T20123 15632-15638 JJ denotes GATA-3
T20124 15639-15649 NN denotes expression
T20125 15650-15651 CD denotes 2
T20126 15652-15653 NN denotes h
T20127 15654-15659 IN denotes after
T20128 15660-15670 NN denotes inhalation
T20129 15671-15673 IN denotes of
T20130 15674-15676 NNP denotes FP
T20131 15676-15677 . denotes .
T20132 15678-15685 NNP denotes Histone
T20133 15686-15688 NNP denotes H1
T20134 15689-15692 CC denotes and
T20135 15693-15698 NNP denotes MEK-1
T20136 15699-15713 VBG denotes immunoblotting
T20137 15714-15723 VBN denotes confirmed
T20138 15724-15734 JJ denotes equivalent
T20139 15735-15740 JJ denotes total
T20140 15741-15748 NN denotes protein
T20141 15749-15756 VBG denotes loading
T20142 15757-15760 IN denotes for
T20143 15761-15764 DT denotes the
T20144 15765-15772 JJ denotes nuclear
T20145 15773-15776 CC denotes and
T20146 15777-15788 JJ denotes cytoplasmic
T20147 15789-15798 NNS denotes fractions
T20148 15799-15811 RB denotes respectively
T20149 15811-15812 . denotes .
T20150 15813-15827 NN denotes Quantification
T20151 15828-15830 IN denotes of
T20152 15831-15834 DT denotes the
T20153 15835-15847 NN denotes densitometry
T20154 15848-15852 NNS denotes data
T20155 15853-15855 IN denotes in
T20156 15856-15857 -LRB- denotes (
T20157 15857-15858 NNP denotes C
T20158 15858-15859 -RRB- denotes )
T20159 15860-15863 CC denotes and
T20160 15864-15865 -LRB- denotes (
T20161 15865-15866 NNP denotes D
T20162 15866-15867 -RRB- denotes )
T20163 15868-15870 VBZ denotes is
T20164 15871-15876 VBN denotes shown
T20165 15877-15879 IN denotes as
T20166 15880-15881 DT denotes a
T20167 15882-15898 NNS denotes box-and-whiskers
T20168 15899-15903 NN denotes plot
T20169 15904-15906 IN denotes of
T20170 15907-15914 NNS denotes results
T20171 15915-15919 IN denotes from
T20172 15920-15921 JJ denotes n
T20173 15922-15923 SYM denotes =
T20174 15924-15925 CD denotes 6
T20175 15926-15938 NNS denotes participants
T20176 15939-15942 IN denotes for
T20177 15943-15948 WDT denotes which
T20178 15949-15953 NNS denotes data
T20179 15954-15958 VBD denotes were
T20180 15959-15968 JJ denotes available
T20181 15968-15969 . denotes .
T20182 15970-15971 SYM denotes *
T20183 15971-15972 NN denotes p
T20184 15972-15973 NN denotes <
T20185 15973-15977 CD denotes 0.05
T20186 15978-15986 VBN denotes compared
T20187 15987-15989 TO denotes to
T20188 15990-15997 VB denotes control
T20189 15997-15998 . denotes .
T20190 15999-16000 -LRB- denotes (
T20191 16000-16001 NNP denotes E
T20192 16001-16002 -RRB- denotes )
T20193 16003-16010 NNP denotes Western
T20194 16011-16015 NN denotes blot
T20195 16016-16024 NNS denotes analyses
T20196 16025-16027 IN denotes of
T20197 16028-16033 NNP denotes PBMCs
T20198 16034-16046 VBD denotes demonstrated
T20199 16047-16048 DT denotes a
T20200 16049-16063 JJ denotes time-dependent
T20201 16064-16072 NN denotes decrease
T20202 16073-16075 IN denotes in
T20203 16076-16080 JJ denotes dual
T20204 16081-16096 NN denotes phosphorylation
T20205 16097-16098 -LRB- denotes (
T20206 16098-16111 NN denotes threonine-180
T20207 16112-16115 CC denotes and
T20208 16116-16128 NN denotes tyrosine-182
T20209 16128-16129 -RRB- denotes )
T20210 16130-16132 IN denotes of
T20211 16133-16136 CD denotes p38
T20212 16137-16141 NNP denotes MAPK
T20213 16142-16147 IN denotes after
T20214 16148-16158 NN denotes inhalation
T20215 16159-16161 IN denotes of
T20216 16162-16164 NNP denotes FP
T20217 16165-16166 -LRB- denotes (
T20218 16166-16169 CD denotes 500
T20219 16170-16172 NN denotes µg
T20220 16172-16173 -RRB- denotes )
T20221 16173-16174 . denotes .
T20222 16175-16178 DT denotes The
T20223 16179-16186 NNS denotes results
T20224 16187-16192 VBN denotes shown
T20225 16193-16195 IN denotes in
T20226 16196-16197 -LRB- denotes (
T20227 16197-16198 NNP denotes E
T20228 16198-16199 -RRB- denotes )
T20229 16200-16203 VBP denotes are
T20230 16204-16218 NN denotes representative
T20231 16219-16221 IN denotes of
T20232 16222-16229 NNS denotes samples
T20233 16230-16234 IN denotes from
T20234 16235-16238 CD denotes two
T20235 16239-16251 NNS denotes participants
T20236 16251-16252 . denotes .
R7296 T8451 T8452 det The,Effect
R7297 T8452 T8463 nsubj Effect,are
R7298 T8453 T8452 prep of,Effect
R7299 T8454 T8453 pobj Corticosteroids,of
R7300 T8455 T8452 prep on,Effect
R7301 T8456 T8458 compound GATA-3,Translocation
R7302 T8457 T8458 compound Nuclear,Translocation
R7303 T8458 T8455 pobj Translocation,on
R7304 T8459 T8458 cc and,Translocation
R7305 T8460 T8462 compound IL-4,Corticosteroids
R7306 T8461 T8462 compound mRNA,Corticosteroids
R7307 T8462 T8458 conj Corticosteroids,Translocation
R7308 T8463 T8463 ROOT are,are
R7309 T8464 T8463 acomp effective,are
R7310 T8465 T8464 prep in,effective
R7311 T8466 T8465 pcomp inhibiting,in
R7312 T8467 T8470 amod GATA-3-regulated,expression
R7313 T8468 T8469 compound IL-4,gene
R7314 T8469 T8470 compound gene,expression
R7315 T8470 T8466 dobj expression,inhibiting
R7316 T8471 T8466 prep in,inhibiting
R7317 T8472 T8471 pobj vitro,in
R7318 T8473 T8471 cc and,in
R7319 T8474 T8471 conj in,in
R7320 T8475 T8474 pobj vivo,in
R7321 T8476 T8478 nmod [,]
R7322 T8477 T8478 nummod 32,]
R7323 T8478 T8463 attr ],are
R7324 T8479 T8463 punct .,are
R7325 T8480 T8482 nsubj We,investigated
R7326 T8481 T8482 advmod therefore,investigated
R7327 T8482 T8482 ROOT investigated,investigated
R7328 T8483 T8485 mark whether,affect
R7329 T8484 T8485 nsubj corticosteroids,affect
R7347 T8502 T8502 ROOT resulted,resulted
R7348 T8503 T8502 prep in,resulted
R7349 T8504 T8508 det a,translocation
R7350 T8505 T8508 amod rapid,translocation
R7351 T8506 T8508 nmod cytoplasmic/nuclear,translocation
R7352 T8507 T8508 compound GATA-3,translocation
R7353 T8508 T8503 pobj translocation,in
R7354 T8509 T8510 punct (,Figure
R7355 T8510 T8511 nmod Figure,1A
R7356 T8511 T8508 appos 1A,translocation
R7357 T8512 T8508 punct ),translocation
R7358 T8513 T8502 punct ",",resulted
R7359 T8514 T8502 advcl confirming,resulted
R7360 T8515 T8517 poss our,results
R7361 T8516 T8517 amod previous,results
R7362 T8517 T8514 dobj results,confirming
R7363 T8518 T8520 nmod [,]
R7364 T8519 T8520 nummod 12,]
R7365 T8520 T8517 appos ],results
R7366 T8521 T8502 punct .,resulted
R7367 T8522 T8524 nsubj We,confirmed
R7368 T8523 T8524 advmod also,confirmed
R7369 T8524 T8524 ROOT confirmed,confirmed
R7370 T8525 T8527 det a,separation
R7371 T8526 T8527 amod clear,separation
R7372 T8527 T8524 dobj separation,confirmed
R7373 T8528 T8527 prep of,separation
R7374 T8529 T8532 amod nuclear,fractions
R7375 T8530 T8529 cc and,nuclear
R7376 T8531 T8529 conj cytosolic,nuclear
R7377 T8532 T8528 pobj fractions,of
R7378 T8533 T8534 mark as,indicated
R7379 T8534 T8527 advcl indicated,separation
R7380 T8535 T8534 agent by,indicated
R7381 T8536 T8535 pobj histone,by
R7382 T8537 T8536 nummod H1,histone
R7383 T8538 T8536 cc and,histone
R7384 T8539 T8540 nummod MEK-1,markers
R7385 T8540 T8536 conj markers,histone
R7386 T8541 T8543 punct (,1B
R7387 T8542 T8543 compound Figure,1B
R7388 T8543 T8540 appos 1B,markers
R7389 T8544 T8543 punct ),1B
R7390 T8545 T8524 punct .,confirmed
R7391 T8546 T8550 det The,FP
R7392 T8547 T8550 amod potent,FP
R7393 T8548 T8550 amod topical,FP
R7394 T8549 T8550 amod corticosteroid,FP
R7395 T8550 T8551 nsubj FP,caused
R7396 T8551 T8551 ROOT caused,caused
R7397 T8552 T8553 amod sustained,loss
R7398 T8553 T8551 dobj loss,caused
R7399 T8554 T8553 prep of,loss
R7400 T8555 T8557 amod nuclear,expression
R7401 T8556 T8557 amod GATA-3,expression
R7402 T8557 T8554 pobj expression,of
R7403 T8558 T8557 cc and,expression
R7404 T8559 T8560 amod cytoplasmic,retention
R7405 T8560 T8557 conj retention,expression
R7406 T8561 T8557 prep of,expression
R7407 T8562 T8561 pobj GATA-3,of
R7408 T8563 T8553 prep at,loss
R7409 T8564 T8563 pobj concentrations,at
R7410 T8565 T8564 acl ranging,concentrations
R7411 T8566 T8565 prep from,ranging
R7412 T8567 T8568 nummod 10,−
R7413 T8568 T8566 pobj −,from
R7414 T8569 T8571 quantmod 12,10
R7415 T8570 T8571 quantmod to,10
R7416 T8571 T8572 nummod 10,−
R7417 T8572 T8574 nummod −,M
R7418 T8573 T8574 nummod 8,M
R7419 T8574 T8566 pobj M,from
R7420 T8575 T8574 punct ",",M
R7421 T8576 T8577 nsubj which,cover
R7422 T8577 T8574 relcl cover,M
R7423 T8578 T8580 det the,range
R7424 T8579 T8580 amod therapeutic,range
R7425 T8580 T8577 dobj range,cover
R7426 T8581 T8583 nmod [,]
R7427 T8582 T8583 nummod 37,]
R7428 T8583 T8580 appos ],range
R7429 T8584 T8551 punct .,caused
R7430 T8585 T8586 det This,effect
R7431 T8586 T8587 nsubj effect,was
R7432 T8587 T8587 ROOT was,was
R7433 T8588 T8587 attr concentration,was
R7434 T8589 T8588 punct -,concentration
R7435 T8590 T8588 cc and,concentration
R7436 T8591 T8588 conj time-dependent,concentration
R7437 T8592 T8587 punct ",",was
R7438 T8593 T8587 prep with,was
R7439 T8594 T8596 det a,effect
R7440 T8595 T8596 amod peak,effect
R7441 T8596 T8593 pobj effect,with
R7442 T8597 T8596 prep of,effect
R7443 T8598 T8597 pobj 11.6-fold,of
R7444 T8599 T8596 prep at,effect
R7445 T8600 T8601 nummod 30,min
R7446 T8601 T8599 pobj min,at
R7447 T8602 T8601 prep at,min
R7448 T8603 T8604 det a,concentration
R7449 T8604 T8602 pobj concentration,at
R7450 T8605 T8604 prep of,concentration
R7451 T8606 T8608 quantmod 10,8
R7452 T8607 T8608 quantmod −,8
R7453 T8608 T8605 pobj 8,of
R7454 T8609 T8608 quantmod M,8
R7455 T8610 T8612 punct (,1C
R7456 T8611 T8612 compound Figure,1C
R7457 T8612 T8609 appos 1C,M
R7458 T8613 T8612 punct ),1C
R7459 T8614 T8587 cc and,was
R7460 T8615 T8616 auxpass was,associated
R7461 T8616 T8624 parataxis associated,stimulated
R7462 T8617 T8616 prep with,associated
R7463 T8618 T8619 amod marked,reductions
R7464 T8619 T8617 pobj reductions,with
R7465 T8620 T8619 prep in,reductions
R7466 T8621 T8622 amod anti-CD3,/
R7467 T8622 T8620 pobj /,in
R7468 T8623 T8622 nummod CD28,/
R7469 T8624 T8587 conj stimulated,was
R7470 T8625 T8624 dobj IL-4,stimulated
R7471 T8626 T8625 cc and,IL-4
R7472 T8627 T8625 conj IL-5,IL-4
R7473 T8628 T8629 compound mRNA,expression
R7474 T8629 T8625 conj expression,IL-4
R7475 T8630 T8631 punct (,Figure
R7476 T8631 T8629 appos Figure,expression
R7477 T8632 T8631 nummod 1D,Figure
R7478 T8633 T8631 punct ),Figure
R7479 T8634 T8631 cc and,Figure
R7480 T8635 T8636 det a,loss
R7481 T8636 T8625 appos loss,IL-4
R7487 T8642 T8644 amod native,promoter
R7849 T9110 T9111 nsubj GR,Competes
R7850 T9111 T9111 ROOT Competes,Competes
R7851 T9112 T9111 prep with,Competes
R7852 T9113 T9112 pobj GATA-3,with
R7853 T9114 T9113 prep for,GATA-3
R7854 T9115 T9114 pobj Importin-α,for
R7855 T9116 T9117 nsubj We,confirmed
R7856 T9117 T9111 ccomp confirmed,Competes
R7857 T9118 T9117 cc and,confirmed
R7858 T9119 T9117 conj extended,confirmed
R7859 T9120 T9121 amod previous,data
R7860 T9121 T9119 dobj data,extended
R7861 T9122 T9124 nmod [,]
R7862 T9123 T9124 nummod 20,]
R7863 T9124 T9126 nsubj ],show
R7864 T9125 T9126 aux to,show
R7865 T9126 T9119 advcl show,extended
R7866 T9127 T9126 dobj that,show
R7867 T9128 T9129 compound ligand-activated,GR
R7868 T9129 T9127 nsubj GR,that
R7869 T9130 T9132 advmod as,as
R7870 T9131 T9132 advmod well,as
R7871 T9132 T9129 cc as,GR
R7872 T9133 T9134 amod GATA-3,uses
R7873 T9134 T9129 conj uses,GR
R7874 T9135 T9129 conj importin-α,GR
R7875 T9136 T9135 prep for,importin-α
R7876 T9137 T9145 poss its,)
R7877 T9138 T9139 amod nuclear,import
R7878 T9139 T9145 nmod import,)
R7879 T9140 T9141 punct (,Figure
R7880 T9141 T9145 nmod Figure,)
R7881 T9142 T9141 nummod 2A,Figure
R7882 T9143 T9141 cc and,Figure
R7883 T9144 T9141 conj 2B,Figure
R7884 T9145 T9135 punct ),importin-α
R7885 T9146 T9111 punct .,Competes
R7886 T9147 T9148 det This,interaction
R7887 T9148 T9153 nsubj interaction,was
R7888 T9149 T9148 prep between,interaction
R7889 T9150 T9149 pobj GR,between
R7890 T9151 T9150 cc and,GR
R7891 T9152 T9150 conj importin-α,GR
R7892 T9153 T9153 ROOT was,was
R7893 T9154 T9153 acomp significant,was
R7894 T9155 T9153 prep at,was
R7895 T9156 T9155 pobj concentrations,at
R7896 T9157 T9158 advmod as,low
R7897 T9158 T9156 amod low,concentrations
R7898 T9159 T9158 prep as,low
R7899 T9160 T9161 nummod 10,−
R7900 T9161 T9159 pobj −,as
R7901 T9162 T9163 nummod 12,M
R7902 T9163 T9158 npadvmod M,low
R7903 T9164 T9153 cc and,was
R7904 T9165 T9166 auxpass was,maximal
R7905 T9166 T9153 conj maximal,was
R7906 T9167 T9166 prep with,maximal
R7907 T9168 T9170 quantmod 10,8
R7908 T9169 T9170 quantmod −,8
R7909 T9170 T9167 pobj 8,with
R7910 T9171 T9172 compound M,FP
R7911 T9172 T9170 quantmod FP,8
R7912 T9173 T9166 punct .,maximal
R7913 T9174 T9177 amod Subsequent,translocation
R7914 T9175 T9177 nmod GR,translocation
R7915 T9176 T9177 amod nuclear,translocation
R7916 T9177 T9178 nsubj translocation,was
R7917 T9178 T9178 ROOT was,was
R7918 T9179 T9178 acomp rapid,was
R7919 T9180 T9178 cc and,was
R7920 T9181 T9178 conj sustained,was
R7921 T9182 T9181 prep at,sustained
R7922 T9183 T9184 amod significant,levels
R7923 T9184 T9182 pobj levels,at
R7924 T9185 T9181 prep for,sustained
R7925 T9186 T9187 advmod at,least
R7926 T9187 T9188 advmod least,14
R7927 T9188 T9189 nummod 14,h
R7928 T9189 T9185 pobj h,for
R7929 T9190 T9192 punct (,2B
R7930 T9191 T9192 compound Figure,2B
R7931 T9192 T9189 appos 2B,h
R7932 T9193 T9192 punct ),2B
R7933 T9194 T9178 punct .,was
R7934 T9195 T9199 advcl Using,showed
R7935 T9196 T9197 amod IP-Western,blotting
R7936 T9197 T9195 dobj blotting,Using
R7937 T9198 T9199 nsubj we,showed
R7938 T9199 T9199 ROOT showed,showed
R7939 T9200 T9210 mark that,decreased
R7940 T9201 T9210 nsubj FP,decreased
R7941 T9202 T9201 prep at,FP
R7942 T9203 T9205 nummod 10,12
R7943 T9204 T9205 nummod −,12
R7944 T9205 T9202 pobj 12,at
R7945 T9206 T9209 nummod 10,M
R7946 T9207 T9209 nmod −,M
R7947 T9208 T9207 nummod 8,−
R7948 T9209 T9201 conj M,FP
R7949 T9210 T9199 ccomp decreased,showed
R7950 T9211 T9212 det the,association
R7951 T9212 T9210 dobj association,decreased
R7952 T9213 T9212 prep between,association
R7953 T9214 T9213 pobj GATA-3,between
R7954 T9215 T9214 cc and,GATA-3
R7955 T9216 T9214 conj importin-α,GATA-3
R7956 T9217 T9212 acl induced,association
R7957 T9218 T9217 agent by,induced
R7958 T9219 T9222 amod anti-CD3,stimulation
R7959 T9220 T9222 nmod /,stimulation
R7960 T9221 T9222 nummod CD28,stimulation
R7961 T9222 T9218 pobj stimulation,by
R7962 T9223 T9217 prep in,induced
R7963 T9224 T9226 det a,manner
R7964 T9225 T9226 amod concentration-dependent,manner
R7965 T9226 T9223 pobj manner,in
R7966 T9227 T9228 punct (,Figure
R7967 T9228 T9226 appos Figure,manner
R7968 T9229 T9228 npadvmod 2C,Figure
R7969 T9230 T9228 punct ),Figure
R7970 T9231 T9199 punct .,showed
R7971 T9232 T9242 prep In,demonstrated
R7972 T9233 T9232 pobj addition,In
R7973 T9234 T9242 punct ",",demonstrated
R7974 T9235 T9242 advcl using,demonstrated
R7975 T9236 T9237 amod GFP-labelled,GATA-3
R7976 T9237 T9235 dobj GATA-3,using
R7977 T9238 T9237 cc and,GATA-3
R7978 T9239 T9240 amod confocal,microscopy
R7979 T9240 T9237 conj microscopy,GATA-3
R7980 T9241 T9242 nsubj we,demonstrated
R7981 T9242 T9242 ROOT demonstrated,demonstrated
R7982 T9243 T9256 mark that,attenuated
R7983 T9244 T9246 amod GATA-3,import
R7984 T9245 T9246 amod nuclear,import
R7985 T9246 T9256 nsubjpass import,attenuated
R7986 T9247 T9246 prep following,import
R7987 T9248 T9249 compound anti-CD3,/
R7988 T9249 T9247 dobj /,following
R7989 T9250 T9251 nummod CD28,stimulation
R7990 T9251 T9246 appos stimulation,import
R7991 T9252 T9251 prep for,stimulation
R7992 T9253 T9254 nummod 30,min
R7993 T9254 T9252 pobj min,for
R7994 T9255 T9256 auxpass was,attenuated
R7995 T9256 T9242 ccomp attenuated,demonstrated
R7996 T9257 T9256 agent by,attenuated
R7997 T9258 T9257 pobj pretreatment,by
R7998 T9259 T9256 prep with,attenuated
R7999 T9260 T9259 pobj FP,with
R8000 T9261 T9260 punct (,FP
R8001 T9262 T9263 nummod 10,−
R8002 T9263 T9265 npadvmod −,M
R8003 T9264 T9265 nummod 8,M
R8004 T9265 T9260 appos M,FP
R8005 T9266 T9260 punct ),FP
R8006 T9267 T9268 punct (,Figure
R8007 T9268 T9260 appos Figure,FP
R8008 T9269 T9268 nummod 2D,Figure
R8009 T9270 T9242 punct ),demonstrated
R8010 T9271 T9242 punct .,demonstrated
R8744 T10194 T10198 nsubj Effect,inhibits
R8745 T10195 T10194 prep on,Effect
R8746 T10196 T10197 compound MKP-1,Dexamethasone
R8747 T10197 T10195 pobj Dexamethasone,on
R8748 T10198 T10198 ROOT inhibits,inhibits
R8749 T10199 T10201 nummod p38,function
R8750 T10200 T10201 compound MAPK,function
R8751 T10201 T10198 dobj function,inhibits
R8752 T10202 T10201 prep in,function
R8753 T10203 T10205 det a,type
R8754 T10204 T10205 compound cell,type
R8755 T10205 T10202 pobj type,in
R8756 T10206 T10207 amod specific,manner
R8757 T10207 T10201 conj manner,function
R8758 T10208 T10198 prep through,inhibits
R8759 T10209 T10211 det the,induction
R8760 T10210 T10211 amod rapid,induction
R8761 T10211 T10208 pobj induction,through
R8762 T10212 T10211 prep of,induction
R8763 T10213 T10215 det the,kinase
R8764 T10214 T10215 amod dual,kinase
R8765 T10215 T10212 pobj kinase,of
R8766 T10216 T10217 compound phosphatase,MKP-1
R8767 T10217 T10215 appos MKP-1,kinase
R8768 T10218 T10220 punct (,phosphatase-1
R8769 T10219 T10220 compound MAPK,phosphatase-1
R8770 T10220 T10217 appos phosphatase-1,MKP-1
R8771 T10221 T10220 punct ),phosphatase-1
R8772 T10222 T10217 punct ",",MKP-1
R8773 T10223 T10217 cc and,MKP-1
R8774 T10224 T10225 det this,effect
R8775 T10225 T10226 nsubj effect,lasts
R8776 T10226 T10215 relcl lasts,kinase
R8777 T10227 T10226 prep for,lasts
R8778 T10228 T10230 quantmod up,24
R8779 T10229 T10230 quantmod to,24
R8780 T10230 T10234 nummod 24,]
R8781 T10231 T10232 compound h,[
R8782 T10232 T10234 nmod [,]
R8783 T10233 T10232 nummod 28,[
R8784 T10234 T10227 pobj ],for
R8785 T10235 T10198 punct .,inhibits
R8786 T10236 T10243 nmod FP,treatment
R8787 T10237 T10239 punct (,−
R8788 T10238 T10239 nummod 10,−
R8789 T10239 T10243 nmod −,treatment
R8790 T10240 T10239 nummod 8,−
R8791 T10241 T10239 appos M,−
R8792 T10242 T10239 punct ),−
R8793 T10243 T10255 nsubj treatment,decreased
R8794 T10244 T10243 prep of,treatment
R8795 T10245 T10246 amod HuT-78,cells
R8796 T10246 T10244 pobj cells,of
R8797 T10247 T10246 acl activated,cells
R8798 T10248 T10247 agent by,activated
R8799 T10249 T10250 compound anti-CD3,/
R8800 T10250 T10248 pobj /,by
R8801 T10251 T10250 nummod CD28,/
R8802 T10252 T10247 prep in,activated
R8803 T10253 T10252 pobj vitro,in
R8804 T10254 T10255 advmod significantly,decreased
R8805 T10255 T10255 ROOT decreased,decreased
R8806 T10256 T10258 nummod p38,phosphorylation
R8807 T10257 T10258 compound MAPK,phosphorylation
R8808 T10258 T10255 dobj phosphorylation,decreased
R8809 T10259 T10261 punct (,3A
R8810 T10260 T10261 compound Figure,3A
R8811 T10261 T10258 appos 3A,phosphorylation
R8812 T10262 T10258 punct ),phosphorylation
R8813 T10263 T10258 cc and,phosphorylation
R8814 T10264 T10258 conj activity,phosphorylation
R8815 T10265 T10255 conj measured,decreased
R8816 T10266 T10265 agent by,measured
R8817 T10267 T10266 pobj phosphorylation,by
R8818 T10268 T10267 prep of,phosphorylation
R8819 T10269 T10271 det the,target
R8820 T10270 T10271 amod downstream,target
R8821 T10271 T10268 pobj target,of
R8822 T10272 T10271 appos ATF-2,target
R8823 T10273 T10275 punct (,3B
R8824 T10274 T10275 compound Figure,3B
R8825 T10275 T10272 appos 3B,ATF-2
R8826 T10276 T10272 punct ),ATF-2
R8827 T10277 T10255 punct .,decreased
R8828 T10278 T10279 det This,effect
R8829 T10279 T10281 nsubjpass effect,detected
R8830 T10280 T10281 auxpass was,detected
R8831 T10281 T10281 ROOT detected,detected
R8832 T10282 T10281 prep at,detected
R8833 T10283 T10284 nummod 30,min
R8834 T10284 T10282 pobj min,at
R8835 T10285 T10281 cc and,detected
R8836 T10286 T10281 conj lasted,detected
R8837 T10287 T10286 prep for,lasted
R8838 T10288 T10289 advmod at,least
R8839 T10289 T10290 advmod least,14
R8840 T10290 T10291 nummod 14,h
R8841 T10291 T10287 pobj h,for
R8842 T10292 T10294 punct (,3B
R8843 T10293 T10294 compound Figure,3B
R8844 T10294 T10291 appos 3B,h
R8845 T10295 T10291 punct ),h
R8846 T10296 T10281 punct .,detected
R8847 T10297 T10306 nsubj FP,reduced
R8848 T10298 T10300 punct (,−
R8849 T10299 T10300 nummod 10,−
R8850 T10300 T10306 nsubj −,reduced
R8851 T10301 T10300 nummod 8,−
R8852 T10302 T10300 appos M,−
R8853 T10303 T10300 punct ),−
R8854 T10304 T10306 advmod also,reduced
R8855 T10305 T10306 advmod significantly,reduced
R8856 T10306 T10306 ROOT reduced,reduced
R8857 T10307 T10309 nmod GATA-3,phosphorylation
R8858 T10308 T10309 compound serine,phosphorylation
R8859 T10309 T10306 dobj phosphorylation,reduced
R8860 T10310 T10309 acl induced,phosphorylation
R8861 T10311 T10310 agent by,induced
R8862 T10312 T10315 amod anti-CD3,stimulation
R8863 T10313 T10315 nmod /,stimulation
R8864 T10314 T10315 nummod CD28,stimulation
R8865 T10315 T10311 pobj stimulation,by
R8866 T10316 T10315 prep in,stimulation
R8867 T10317 T10319 preconj both,time
R8868 T10318 T10319 det a,time
R8869 T10319 T10316 pobj time,in
R8870 T10320 T10319 punct -,time
R8871 T10321 T10319 cc and,time
R8872 T10322 T10323 amod concentration-dependent,manner
R8873 T10323 T10319 conj manner,time
R8874 T10324 T10326 punct (,3C
R8875 T10325 T10326 compound Figure,3C
R8876 T10326 T10323 appos 3C,manner
R8877 T10327 T10326 punct ),3C
R8878 T10328 T10306 punct .,reduced
R8879 T10329 T10330 det This,reduction
R8880 T10330 T10336 nsubjpass reduction,seen
R8881 T10331 T10330 prep in,reduction
R8882 T10332 T10333 amod GATA-3,phosphorylation
R8883 T10333 T10331 pobj phosphorylation,in
R8884 T10334 T10336 auxpass was,seen
R8885 T10335 T10336 advmod also,seen
R8886 T10336 T10336 ROOT seen,seen
R8887 T10337 T10336 prep with,seen
R8888 T10338 T10339 amod lower,concentrations
R8889 T10339 T10337 pobj concentrations,with
R8890 T10340 T10339 prep of,concentrations
R8891 T10341 T10340 pobj FP,of
R8892 T10342 T10336 punct .,seen
R8893 T10343 T10344 nsubj We,found
R8894 T10344 T10344 ROOT found,found
R8895 T10345 T10348 mark that,induced
R8896 T10346 T10348 nsubj FP,induced
R8897 T10347 T10348 advmod significantly,induced
R8898 T10348 T10344 ccomp induced,found
R8899 T10349 T10350 compound MKP-1,mRNA
R8900 T10350 T10348 dobj mRNA,induced
R8901 T10351 T10348 prep in,induced
R8902 T10352 T10354 predet both,time
R8903 T10353 T10354 det a,time
R8904 T10354 T10351 pobj time,in
R8905 T10355 T10348 punct -,induced
R8906 T10356 T10348 cc and,induced
R8907 T10357 T10358 amod concentration-dependent,manner
R8908 T10358 T10348 conj manner,induced
R8909 T10359 T10358 punct ",",manner
R8910 T10360 T10358 acl reaching,manner
R8911 T10361 T10362 det a,plateau
R8912 T10362 T10360 dobj plateau,reaching
R8913 T10363 T10360 prep at,reaching
R8914 T10364 T10365 nummod 10,−
R8915 T10365 T10367 compound −,M
R8916 T10366 T10367 compound 8,M
R8917 T10367 T10363 pobj M,at
R8918 T10368 T10360 prep after,reaching
R8919 T10369 T10370 nummod 10,min
R8920 T10370 T10368 pobj min,after
R8921 T10371 T10372 punct (,Figure
R8922 T10372 T10376 nmod Figure,)
R8923 T10373 T10372 nummod 3D,Figure
R8924 T10374 T10372 cc and,Figure
R8925 T10375 T10372 conj 3E,Figure
R8926 T10376 T10358 punct ),manner
R8927 T10377 T10344 punct .,found
R8928 T10378 T10396 advmod However,seen
R8929 T10379 T10396 punct ",",seen
R8930 T10380 T10381 det the,effects
R8931 T10381 T10396 nsubjpass effects,seen
R8932 T10382 T10381 prep of,effects
R8933 T10383 T10382 pobj FP,of
R8934 T10384 T10381 prep on,effects
R8935 T10385 T10387 nmod GATA-3,import
R8936 T10386 T10387 amod nuclear,import
R8937 T10387 T10384 pobj import,on
R8938 T10388 T10387 punct ",",import
R8939 T10389 T10390 amod importin-α,association
R8940 T10390 T10387 conj association,import
R8941 T10391 T10390 cc and,association
R8942 T10392 T10390 conj IL-4,association
R8943 T10393 T10394 compound mRNA,expression
R8944 T10394 T10390 conj expression,association
R8945 T10395 T10396 auxpass are,seen
R8946 T10396 T10396 ROOT seen,seen
R8947 T10397 T10396 prep at,seen
R8948 T10398 T10400 nummod "10,000-fold",concentrations
R8949 T10399 T10400 amod lower,concentrations
R8950 T10400 T10397 pobj concentrations,at
R8951 T10401 T10400 punct (,concentrations
R8952 T10402 T10403 nummod 10,−
R8953 T10403 T10400 appos −,concentrations
R8954 T10404 T10405 nummod 12,M
R8955 T10405 T10403 appos M,−
R8956 T10406 T10403 punct ",",−
R8957 T10407 T10408 compound see,Figure
R8958 T10408 T10400 appos Figure,concentrations
R8959 T10409 T10408 nummod 2,Figure
R8960 T10410 T10408 punct ),Figure
R8961 T10411 T10396 punct .,seen
R8962 T10412 T10434 advcl Using,demonstrated
R8963 T10413 T10417 det an,assay
R8964 T10414 T10417 nmod in,assay
R8965 T10415 T10416 amod vitro,competition
R8966 T10416 T10417 compound competition,assay
R8967 T10417 T10412 dobj assay,Using
R8968 T10418 T10420 punct (,4A
R8969 T10419 T10420 compound Figure,4A
R8970 T10420 T10417 appos 4A,assay
R8971 T10421 T10420 punct ),4A
R8989 T10439 T10434 conj increased,demonstrated
R8990 T10440 T10441 amod GR-importin-α,association
R8991 T10441 T10439 dobj association,increased
R8992 T10442 T10439 prep in,increased
R8993 T10443 T10444 det the,presence
R8994 T10444 T10442 pobj presence,in
R8995 T10445 T10444 cc and,presence
R8996 T10446 T10444 conj absence,presence
R8997 T10447 T10446 prep of,absence
R8998 T10448 T10449 amod activated,GATA-3
R8999 T10449 T10447 pobj GATA-3,of
R9000 T10450 T10452 punct (,4B
R9001 T10451 T10452 compound Figure,4B
R9002 T10452 T10449 appos 4B,GATA-3
R9003 T10453 T10449 punct ),GATA-3
R9004 T10454 T10439 punct .,increased
R9005 T10455 T10456 det This,effect
R9006 T10456 T10457 nsubj effect,is
R9007 T10457 T10457 ROOT is,is
R9008 T10458 T10457 neg not,is
R9009 T10459 T10457 acomp mutual,is
R9010 T10460 T10457 punct ",",is
R9011 T10461 T10462 mark since,activated
R9012 T10462 T10466 advcl activated,block
R9013 T10463 T10466 nsubj GATA-3,block
R9014 T10464 T10466 aux did,block
R9015 T10465 T10466 neg not,block
R9016 T10466 T10457 advcl block,is
R9017 T10467 T10466 dobj GR,block
R9018 T10468 T10469 amod importin-α,association
R9019 T10469 T10466 dep association,block
R9020 T10470 T10471 punct (,Figure
R9021 T10471 T10472 nmod Figure,4C
R9022 T10472 T10469 appos 4C,association
R9023 T10473 T10469 punct ),association
R9024 T10474 T10457 punct .,is
R9025 T10475 T10476 det These,data
R9026 T10476 T10478 nsubj data,suggest
R9027 T10477 T10478 advmod also,suggest
R9028 T10478 T10478 ROOT suggest,suggest
R9029 T10479 T10481 mark that,activated
R9030 T10480 T10481 nsubj both,activated
R9031 T10481 T10478 ccomp activated,suggest
R9032 T10482 T10481 dobj GR,activated
R9033 T10483 T10482 cc and,GR
R9034 T10484 T10482 conj phospho-GATA-3,GR
R9035 T10485 T10487 aux can,associate
R9036 T10486 T10487 advmod directly,associate
R9037 T10487 T10478 ccomp associate,suggest
R9038 T10488 T10487 prep with,associate
R9039 T10489 T10488 pobj importin-α,with
R9040 T10490 T10492 punct (,4D
R9041 T10491 T10492 compound Figure,4D
R9042 T10492 T10489 appos 4D,importin-α
R9043 T10493 T10492 punct ),4D
R9044 T10494 T10487 cc and,associate
R9045 T10495 T10496 nsubj that,activated
R9046 T10496 T10487 conj activated,associate
R9047 T10497 T10498 compound GR,attenuates
R9048 T10498 T10498 ROOT attenuates,attenuates
R9049 T10499 T10503 det the,interaction
R9050 T10500 T10503 amod phospho-GATA-3,interaction
R9051 T10501 T10503 nmod /,interaction
R9052 T10502 T10503 amod importin-α,interaction
R9053 T10503 T10498 dobj interaction,attenuates
R9054 T10504 T10498 prep in,attenuates
R9055 T10505 T10507 det a,manner
R9056 T10506 T10507 amod concentration-dependent,manner
R9057 T10507 T10504 pobj manner,in
R9058 T10508 T10509 punct (,Figure
R9059 T10509 T10498 appos Figure,attenuates
R9060 T10510 T10509 nummod 4E,Figure
R9061 T10511 T10509 punct ),Figure
R9062 T10512 T10478 punct .,suggest
R9063 T10513 T10516 advmod Together,suggests
R9064 T10514 T10516 punct ",",suggests
R9065 T10515 T10516 nsubj this,suggests
R9066 T10516 T10516 ROOT suggests,suggests
R9067 T10517 T10521 mark that,compete
R9068 T10518 T10519 compound ligand-activated,GR
R9069 T10519 T10521 nsubj GR,compete
R9070 T10520 T10521 aux may,compete
R9071 T10521 T10516 ccomp compete,suggests
R9072 T10522 T10521 prep with,compete
R9073 T10523 T10522 pobj phospho-GATA-3,with
R9074 T10524 T10523 prep for,phospho-GATA-3
R9075 T10525 T10524 pobj importin-α,for
R9076 T10526 T10525 cc and,importin-α
R9077 T10527 T10528 advmod thereby,limit
R9078 T10528 T10525 conj limit,importin-α
R9079 T10529 T10531 amod GATA-3,import
R9080 T10530 T10531 amod nuclear,import
R9081 T10531 T10528 dobj import,limit
R9082 T10532 T10516 punct .,suggests
R9083 T10533 T10535 amod Other,interpretations
R9084 T10534 T10535 amod possible,interpretations
R9085 T10535 T10540 nsubj interpretations,include
R9086 T10536 T10535 prep of,interpretations
R9087 T10537 T10538 poss our,results
R9088 T10538 T10536 pobj results,of
R9089 T10539 T10540 aux could,include
R9090 T10540 T10540 ROOT include,include
R9091 T10541 T10542 det an,effect
R9092 T10542 T10540 dobj effect,include
R9093 T10543 T10542 prep of,effect
R9094 T10544 T10543 pobj FP,of
R9095 T10545 T10542 prep on,effect
R9096 T10546 T10548 nmod GATA-3,export
R9097 T10547 T10548 amod nuclear,export
R9098 T10548 T10545 pobj export,on
R9099 T10549 T10548 cc and/or,export
R9100 T10550 T10548 conj degradation,export
R9101 T10551 T10540 punct .,include
R9102 T10552 T10553 compound Leptomycin,B
R9103 T10553 T10562 nsubj B,affect
R9104 T10554 T10553 punct ",",B
R9105 T10555 T10556 nsubj which,inhibits
R9106 T10556 T10553 relcl inhibits,B
R9107 T10557 T10558 amod nuclear,export
R9108 T10558 T10556 dobj export,inhibits
R9109 T10559 T10562 punct ",",affect
R9110 T10560 T10562 aux did,affect
R9111 T10561 T10562 neg not,affect
R9112 T10562 T10562 ROOT affect,affect
R9113 T10563 T10564 det the,ability
R9114 T10564 T10562 dobj ability,affect
R9115 T10565 T10564 prep of,ability
R9116 T10566 T10565 pobj FP,of
R9117 T10567 T10568 aux to,block
R9118 T10568 T10564 acl block,ability
R9119 T10569 T10571 amod GATA-3,localization
R9120 T10570 T10571 amod nuclear,localization
R9121 T10571 T10568 dobj localization,block
R9122 T10572 T10574 punct (,5A
R9123 T10573 T10574 compound Figure,5A
R9124 T10574 T10571 appos 5A,localization
R9125 T10575 T10574 punct ),5A
R9126 T10576 T10562 punct .,affect
R9127 T10577 T10580 advmod Additionally,had
R9128 T10578 T10580 punct ",",had
R9129 T10579 T10580 nsubj FP,had
R9130 T10580 T10580 ROOT had,had
R9131 T10581 T10582 det no,effect
R9132 T10582 T10580 dobj effect,had
R9133 T10583 T10582 prep on,effect
R9134 T10584 T10587 amod whole,expression
R9135 T10585 T10586 compound cell,GATA-3
R9136 T10586 T10587 compound GATA-3,expression
R9137 T10587 T10583 pobj expression,on
R9138 T10588 T10580 prep during,had
R9139 T10589 T10591 det the,course
R9140 T10590 T10591 compound time,course
R9141 T10591 T10588 pobj course,during
R9142 T10592 T10591 prep of,course
R9143 T10593 T10594 det these,experiments
R9144 T10594 T10592 pobj experiments,of
R9145 T10595 T10597 punct (,5B
R9146 T10596 T10597 compound Figure,5B
R9147 T10597 T10594 appos 5B,experiments
R9148 T10598 T10597 punct ),5B
R9149 T10599 T10580 punct .,had
R9150 T10600 T10602 cc Nor,addition
R9151 T10601 T10602 aux did,addition
R9152 T10602 T10602 ROOT addition,addition
R9153 T10603 T10602 prep of,addition
R9154 T10604 T10603 pobj FP,of
R9155 T10605 T10602 advmod subsequent,addition
R9156 T10606 T10607 aux to,anti-CD3
R9157 T10607 T10605 xcomp anti-CD3,subsequent
R9158 T10608 T10611 nmod /,translocation
R9159 T10609 T10608 nummod CD28,/
R9160 T10610 T10611 amod nuclear,translocation
R9161 T10611 T10612 nsubj translocation,affect
R9162 T10612 T10607 conj affect,anti-CD3
R9163 T10613 T10615 nmod GATA-3,residency
R9164 T10614 T10615 amod nuclear,residency
R9165 T10615 T10612 dobj residency,affect
R9166 T10616 T10618 punct (,5C
R9167 T10617 T10618 compound Figure,5C
R9168 T10618 T10615 appos 5C,residency
R9169 T10619 T10615 punct ),residency
R9170 T10620 T10605 punct ",",subsequent
R9171 T10621 T10605 advcl suggesting,subsequent
R9172 T10622 T10627 mark that,enhance
R9173 T10623 T10624 amod activated,GR
R9174 T10624 T10627 nsubj GR,enhance
R9175 T10625 T10627 aux does,enhance
R9176 T10626 T10627 neg not,enhance
R9177 T10627 T10621 ccomp enhance,suggesting
R9178 T10628 T10630 amod GATA-3,export
R9179 T10629 T10630 amod nuclear,export
R9180 T10630 T10627 dobj export,enhance
R9181 T10631 T10605 punct .,subsequent
R9182 T10632 T10642 advmod Finally,was
R9183 T10633 T10642 punct ",",was
R9184 T10634 T10635 det the,effect
R9185 T10635 T10642 nsubj effect,was
R9186 T10636 T10635 prep of,effect
R9187 T10637 T10636 pobj FP,of
R9188 T10638 T10635 prep on,effect
R9189 T10639 T10641 nmod GATA-3,import
R9190 T10640 T10641 amod nuclear,import
R9191 T10641 T10638 pobj import,on
R9192 T10642 T10642 ROOT was,was
R9193 T10643 T10642 neg not,was
R9194 T10644 T10642 acomp nonspecific,was
R9195 T10645 T10642 punct ",",was
R9196 T10646 T10654 mark since,had
R9197 T10647 T10652 nmod FP,M
R9198 T10648 T10650 punct (,−
R9199 T10649 T10650 nummod 10,−
R9200 T10650 T10652 nmod −,M
R9201 T10651 T10650 nummod 8,−
R9202 T10652 T10646 pobj M,since
R9203 T10653 T10654 punct ),had
R9204 T10654 T10642 advcl had,was
R9205 T10655 T10656 det no,effect
R9206 T10656 T10654 dobj effect,had
R9207 T10657 T10656 prep on,effect
R10256 T11943 T11944 nmod ex,vivo
R10257 T11944 T11945 nsubj vivo,demonstrated
R10258 T11945 T11945 ROOT demonstrated,demonstrated
R10259 T11946 T11948 det a,decrease
R10260 T11947 T11948 amod concentration-dependent,decrease
R10261 T11948 T11945 dobj decrease,demonstrated
R10262 T11949 T11948 prep in,decrease
R10263 T11950 T11952 det the,interaction
R10264 T11951 T11952 amod direct,interaction
R10265 T11952 T11949 pobj interaction,in
R10266 T11953 T11952 prep between,interaction
R10267 T11954 T11953 pobj phospho-GATA-3,between
R10268 T11955 T11954 cc and,phospho-GATA-3
R10269 T11956 T11954 conj importin-α,phospho-GATA-3
R10270 T11957 T11956 prep in,importin-α
R10271 T11958 T11957 pobj PBMCs,in
R10272 T11959 T11954 prep from,phospho-GATA-3
R10273 T11960 T11959 pobj patients,from
R10274 T11961 T11960 prep with,patients
R10275 T11962 T11965 compound asthma,6A
R10276 T11963 T11964 punct (,Figure
R10277 T11964 T11965 compound Figure,6A
R10278 T11965 T11961 pobj 6A,with
R10279 T11966 T11965 cc and,6A
R10280 T11967 T11965 conj 6B,6A
R10281 T11968 T11967 punct ),6B
R10282 T11969 T11965 punct ",",6A
R10283 T11970 T11973 nsubjpass which,inhibited
R10284 T11971 T11973 auxpass was,inhibited
R10285 T11972 T11973 advmod significantly,inhibited
R10286 T11973 T11960 relcl inhibited,patients
R10287 T11974 T11973 prep at,inhibited
R10288 T11975 T11979 nummod 10,FP
R10289 T11976 T11979 nummod −,FP
R10290 T11977 T11979 nummod 12,FP
R10291 T11978 T11979 compound M,FP
R10292 T11979 T11974 pobj FP,at
R10293 T11980 T11979 punct (,FP
R10294 T11981 T11982 nmod p,<
R10295 T11982 T11983 nmod <,0.001
R10296 T11983 T11979 appos 0.001,FP
R10297 T11984 T11983 punct ",",0.001
R10298 T11985 T11983 conj ANOVA,0.001
R10299 T11986 T11985 cc and,ANOVA
R10300 T11987 T11988 compound Newman-Keuls,test
R10301 T11988 T11985 conj test,ANOVA
R10302 T11989 T11988 punct ),test
R10303 T11990 T11973 cc and,inhibited
R10304 T11991 T11992 advmod completely,attenuated
R10305 T11992 T11973 conj attenuated,inhibited
R10306 T11993 T11992 prep by,attenuated
R10307 T11994 T11998 nummod 10,FP
R10308 T11995 T11996 quantmod −,8
R10309 T11996 T11998 nummod 8,FP
R10310 T11997 T11998 compound M,FP
R10311 T11998 T12001 nmod FP,<
R10312 T11999 T12001 punct (,<
R10313 T12000 T12001 nmod p,<
R10314 T12001 T11993 pobj <,by
R10315 T12002 T12001 appos 0.001,<
R10316 T12003 T12001 punct ",",<
R10317 T12004 T12001 conj ANOVA,<
R10318 T12005 T12004 cc and,ANOVA
R10319 T12006 T12007 compound Newman-Keuls,test
R10320 T12007 T12004 conj test,ANOVA
R10321 T12008 T12001 punct ),<
R10322 T12009 T11945 punct .,demonstrated
R10323 T12010 T12015 poss Our,studies
R10324 T12011 T12015 amod previous,studies
R10325 T12012 T12015 compound T,studies
R10326 T12013 T12014 compound cell,line
R10327 T12014 T12015 compound line,studies
R10328 T12015 T12016 nsubj studies,indicated
R10329 T12016 T12016 ROOT indicated,indicated
R10330 T12017 T12023 mark that,suppresses
R10331 T12018 T12023 nsubj 10,suppresses
R10332 T12019 T12023 dep −,suppresses
R10333 T12020 T12023 dep 12,suppresses
R10334 T12021 T12022 compound M,FP
R10350 T12037 T12038 punct (,see
R10351 T12038 T12016 parataxis see,indicated
R10352 T12039 T12038 npadvmod Figures,see
R10353 T12040 T12043 nmod 1D,)
R10354 T12041 T12040 cc and,1D
R10355 T12042 T12040 conj 2,1D
R10356 T12043 T12038 punct ),see
R10357 T12044 T12016 punct .,indicated
R10358 T12045 T12046 det This,concentration
R10359 T12046 T12047 nsubj concentration,is
R10360 T12047 T12047 ROOT is,is
R10361 T12048 T12047 acomp close,is
R10362 T12049 T12050 aux to,peak
R10363 T12050 T12047 xcomp peak,is
R10364 T12051 T12052 compound plasma,levels
R10365 T12052 T12050 dobj levels,peak
R10366 T12053 T12052 acl obtained,levels
R10367 T12054 T12053 prep from,obtained
R10368 T12055 T12056 amod asthmatic,patients
R10369 T12056 T12054 pobj patients,from
R10370 T12057 T12056 acl treated,patients
R10371 T12058 T12057 prep with,treated
R10372 T12059 T12060 amod inhaled,FP
R10373 T12060 T12065 nmod FP,[
R10374 T12061 T12060 punct (,FP
R10375 T12062 T12063 nummod 500,µg
R10376 T12063 T12060 appos µg,FP
R10377 T12064 T12065 punct ),[
R10378 T12065 T12067 nmod [,]
R10379 T12066 T12067 nummod 27,]
R10380 T12067 T12058 pobj ],with
R10381 T12068 T12047 punct .,is
R10382 T12069 T12070 compound Inhaled,FP
R10383 T12070 T12082 nsubj FP,reduced
R10384 T12071 T12073 punct (,µg
R10385 T12072 T12073 nummod 500,µg
R10386 T12073 T12070 appos µg,FP
R10387 T12074 T12073 punct ),µg
R10388 T12075 T12070 appos treatment,FP
R10389 T12076 T12075 prep of,treatment
R10390 T12077 T12080 nummod seven,patients
R10391 T12078 T12080 amod steroid-naive,patients
R10392 T12079 T12080 compound asthma,patients
R10393 T12080 T12076 pobj patients,of
R10394 T12081 T12082 advmod significantly,reduced
R10395 T12082 T12082 ROOT reduced,reduced
R10396 T12083 T12082 dobj GATA-3,reduced
R10397 T12084 T12085 amod importin-α,interaction
R10398 T12085 T12083 appos interaction,GATA-3
R10399 T12086 T12085 prep in,interaction
R10400 T12087 T12086 pobj vivo,in
R10401 T12088 T12082 prep in,reduced
R10402 T12089 T12091 det a,manner
R10403 T12090 T12091 amod time-dependent,manner
R10404 T12091 T12088 pobj manner,in
R10405 T12092 T12082 punct .,reduced
R10406 T12093 T12094 nsubj This,produced
R10407 T12094 T12094 ROOT produced,produced
R10408 T12095 T12096 det a,>
R10409 T12096 T12099 compound >,decrease
R10410 T12097 T12098 nummod 90,%
R10411 T12098 T12099 compound %,decrease
R10412 T12099 T12094 dobj decrease,produced
R10413 T12100 T12099 prep in,decrease
R10414 T12101 T12100 pobj GATA-3,in
R10415 T12102 T12103 compound importin-α,association
R10416 T12103 T12099 appos association,decrease
R10417 T12104 T12099 prep at,decrease
R10418 T12105 T12106 nummod 2,h
R10419 T12106 T12104 pobj h,at
R10420 T12107 T12113 punct (,]
R10421 T12108 T12113 amod median,]
R10422 T12109 T12113 compound [,]
R10423 T12110 T12111 nummod 95,%
R10424 T12111 T12113 compound %,]
R10425 T12112 T12113 compound CI,]
R10426 T12113 T12099 appos ],decrease
R10427 T12114 T12113 punct ",",]
R10428 T12115 T12117 nummod "13,494","6,828"
R10429 T12116 T12117 compound [,"6,828"
R10430 T12117 T12113 appos "6,828",]
R10431 T12118 T12119 compound "17,829",]
R10432 T12119 T12113 conj ],]
R10433 T12120 T12119 cc versus,]
R10434 T12121 T12127 dep 879,p
R10435 T12122 T12127 ccomp [,p
R10436 T12123 T12122 nummod 597,[
R10437 T12124 T12122 nummod "1,165",[
R10438 T12125 T12125 ROOT ],]
R10439 T12126 T12127 punct ;,p
R10440 T12127 T12113 parataxis p,]
R10441 T12128 T12127 advmod <,p
R10442 T12129 T12132 nummod 0.05,analysis
R10443 T12130 T12132 poss Friedman,analysis
R10444 T12131 T12130 case 's,Friedman
R10445 T12132 T12128 appos analysis,<
R10446 T12133 T12128 punct ),<
R10447 T12134 T12127 punct .,p
R10448 T12135 T12140 advmod However,reach
R10449 T12136 T12140 punct ",",reach
R10475 T12162 T12163 auxpass were,observed
R10476 T12163 T12163 ROOT observed,observed
R10477 T12164 T12169 advmod when,measured
R10478 T12165 T12169 nsubjpass GATA-3,measured
R10479 T12166 T12167 amod importin-α,association
R10480 T12167 T12165 appos association,GATA-3
R10481 T12168 T12169 auxpass was,measured
R10482 T12169 T12163 advcl measured,observed
R10483 T12170 T12172 punct (,6C
R10484 T12171 T12172 compound Figure,6C
R10485 T12172 T12169 dobj 6C,measured
R10486 T12173 T12172 cc and,6C
R10487 T12174 T12172 conj 6D,6C
R10488 T12175 T12172 punct ),6C
R10489 T12176 T12163 punct .,observed
R10490 T12177 T12179 det The,dose
R10491 T12178 T12179 amod lower,dose
R10492 T12179 T12186 nsubj dose,was
R10493 T12180 T12179 prep of,dose
R10494 T12181 T12180 pobj FP,of
R10495 T12182 T12181 punct (,FP
R10496 T12183 T12184 nummod 100,µg
R10497 T12184 T12181 appos µg,FP
R10498 T12185 T12184 punct ),µg
R10499 T12186 T12186 ROOT was,was
R10500 T12187 T12186 neg not,was
R10501 T12188 T12186 acomp effective,was
R10502 T12189 T12186 punct .,was
R10503 T12190 T12192 det The,interaction
R10504 T12191 T12192 amod attenuated,interaction
R10554 T12241 T12242 compound T,cells
R10555 T12242 T12238 pobj cells,in
R10556 T12243 T12228 punct .,examined
R10557 T12244 T12256 nsubj Treatment,increased
R10558 T12245 T12244 prep with,Treatment
R10559 T12246 T12247 amod inhaled,FP
R10560 T12247 T12245 pobj FP,with
R10561 T12248 T12247 punct (,FP
R10562 T12249 T12250 nummod 500,µg
R10563 T12250 T12247 appos µg,FP
R10564 T12251 T12244 punct ),Treatment
R10565 T12252 T12244 prep for,Treatment
R10566 T12253 T12254 nummod 2,h
R10567 T12254 T12252 pobj h,for
R10568 T12255 T12256 advmod significantly,increased
R10569 T12256 T12256 ROOT increased,increased
R10570 T12257 T12259 nmod GR,translocation
R10571 T12258 T12259 amod nuclear,translocation
R10572 T12259 T12256 dobj translocation,increased
R10573 T12260 T12262 punct (,7A
R10574 T12261 T12262 compound Figure,7A
R10575 T12262 T12259 appos 7A,translocation
R10576 T12263 T12262 punct ),7A
R10577 T12264 T12256 cc and,increased
R10578 T12265 T12266 advmod concomitantly,decreased
R10579 T12266 T12256 conj decreased,increased
R10580 T12267 T12268 det the,number
R10581 T12268 T12266 dobj number,decreased
R10582 T12269 T12268 prep of,number
R10583 T12270 T12276 amod nuclear,cells
R10585 T12272 T12276 amod immunoreactive,cells
R10586 T12273 T12276 amod peripheral,cells
R10587 T12274 T12276 compound blood,cells
R10588 T12275 T12276 compound T,cells
R10589 T12276 T12269 pobj cells,of
R10590 T12277 T12276 punct (,cells
R10591 T12278 T12279 nummod 37,%
R10592 T12279 T12276 appos %,cells
R10593 T12280 T12290 nummod ±,p
R10594 T12281 T12282 nummod 4.2,%
R10595 T12282 T12280 quantmod %,±
R10596 T12283 T12280 cc versus,±
R10597 T12284 T12285 nummod 58.2,%
R10598 T12285 T12290 dep %,p
R10599 T12286 T12288 nummod ±,%
R10600 T12287 T12288 nummod 4.95,%
R10601 T12288 T12285 appos %,%
R10602 T12289 T12290 punct ",",p
R10603 T12290 T12276 parataxis p,cells
R10604 T12291 T12292 punct =,0.016
R10605 T12292 T12290 prep 0.016,p
R10606 T12293 T12303 punct ",",compared
R10607 T12294 T12303 nsubj W,compared
R10608 T12295 T12294 punct =,W
R10609 T12296 T12294 appos 28.0,W
R10610 T12297 T12294 punct ",",W
R10611 T12298 T12301 poss Wilcoxon,test
R10612 T12299 T12298 case 's,Wilcoxon
R10613 T12300 T12301 compound rank,test
R10614 T12301 T12294 appos test,W
R10615 T12302 T12294 punct ),W
R10616 T12303 T12256 prep compared,increased
R10617 T12304 T12303 prep with,compared
R10618 T12305 T12304 pobj placebo,with
R10619 T12306 T12307 mark as,measured
R10620 T12307 T12303 advcl measured,compared
R10621 T12308 T12307 agent by,measured
R10622 T12309 T12308 pobj immunocytochemistry,by
R10623 T12310 T12312 punct (,7A
R10624 T12311 T12312 compound Figure,7A
R10625 T12312 T12309 appos 7A,immunocytochemistry
R10626 T12313 T12312 cc and,7A
R10627 T12314 T12312 conj 7B,7A
R10628 T12315 T12312 punct ),7A
R10629 T12316 T12303 punct .,compared
R10630 T12317 T12319 nsubjpass This,confirmed
R10631 T12318 T12319 auxpass was,confirmed
R10632 T12319 T12319 ROOT confirmed,confirmed
R10633 T12320 T12319 agent by,confirmed
R10634 T12321 T12322 amod Western,blotting
R10635 T12322 T12320 pobj blotting,by
R10636 T12323 T12322 punct ",",blotting
R10637 T12324 T12326 nsubj which,indicated
R10638 T12325 T12326 advmod also,indicated
R10639 T12326 T12319 ccomp indicated,confirmed
R10640 T12327 T12330 mark that,was
R10641 T12328 T12329 det this,effect
R10642 T12329 T12330 nsubj effect,was
R10643 T12330 T12326 ccomp was,indicated
R10644 T12331 T12332 preconj both,time
R10645 T12332 T12330 attr time,was
R10646 T12333 T12332 punct -,time
R10647 T12334 T12332 cc and,time
R10648 T12335 T12332 conj dose-dependent,time
R10649 T12336 T12338 punct (,7C
R10650 T12337 T12338 compound Figure,7C
R10651 T12338 T12335 appos 7C,dose-dependent
R10652 T12339 T12338 cc and,7C
R10653 T12340 T12338 conj 7D,7C
R10654 T12341 T12338 punct ),7C
R10655 T12342 T12319 punct .,confirmed
R10656 T12343 T12345 advmod Thus,inhaled
R10657 T12344 T12345 punct ",",inhaled
R10658 T12345 T12345 ROOT inhaled,inhaled
R10659 T12346 T12345 dobj FP,inhaled
R10660 T12347 T12346 punct (,FP
R10666 T12353 T12351 dobj loss,induced
R10667 T12354 T12351 prep in,induced
R10668 T12355 T12356 amod nuclear,GATA-3
R10669 T12356 T12354 pobj GATA-3,in
R10670 T12357 T12351 prep at,induced
R10671 T12358 T12359 nummod 2,h
R10672 T12359 T12357 pobj h,at
R10673 T12360 T12366 punct (,]
R10674 T12361 T12366 amod median,]
R10675 T12362 T12366 compound [,]
R10676 T12363 T12364 nummod 95,%
R10677 T12364 T12366 compound %,]
R10678 T12365 T12366 compound CI,]
R10679 T12366 T12381 meta ],<
R10680 T12367 T12366 punct ",",]
R10681 T12368 T12370 compound 0.40,0.27
R10682 T12369 T12370 compound [,0.27
R10683 T12370 T12366 appos 0.27,]
R10684 T12371 T12372 nummod 0.53,]
R10685 T12372 T12366 conj ],]
R10686 T12373 T12372 cc versus,]
R10687 T12374 T12376 compound 0.14,0.11
R10688 T12375 T12376 compound [,0.11
R10689 T12376 T12366 appos 0.11,]
R10690 T12377 T12378 nummod 0.19,]
R10691 T12378 T12366 appos ],]
R10692 T12379 T12378 punct ",",]
R10693 T12380 T12381 compound p,<
R10694 T12381 T12351 npadvmod <,induced
R10695 T12382 T12381 nummod 0.05,<
R10696 T12383 T12381 punct ",",<
R10697 T12384 T12400 nmod W,levels
R10698 T12385 T12384 punct =,W
R10699 T12386 T12384 appos 21.00,W
R10700 T12387 T12384 punct ",",W
R10701 T12388 T12391 poss Wilcoxon,test
R10702 T12389 T12388 case 's,Wilcoxon
R10703 T12390 T12391 compound rank,test
R10704 T12391 T12384 appos test,W
R10705 T12392 T12384 punct ),W
R10706 T12393 T12395 punct (,7C
R10707 T12394 T12395 compound Figure,7C
R10708 T12395 T12384 appos 7C,W
R10709 T12396 T12395 punct ),7C
R10710 T12397 T12384 cc and,W
R10711 T12398 T12400 amod cytoplasmic,levels
R10712 T12399 T12400 compound GATA-3,levels
R10713 T12400 T12402 nsubjpass levels,enhanced
R10714 T12401 T12402 auxpass were,enhanced
R10715 T12402 T12351 conj enhanced,induced
R10716 T12403 T12402 agent by,enhanced
R10717 T12404 T12405 amod inhaled,FP
R10718 T12405 T12403 pobj FP,by
R10719 T12406 T12402 prep in,enhanced
R10720 T12407 T12409 det a,manner
R10721 T12408 T12409 amod dose-dependent,manner
R10722 T12409 T12406 pobj manner,in
R10723 T12410 T12416 punct (,]
R10724 T12411 T12416 amod median,]
R10725 T12412 T12416 compound [,]
R10726 T12413 T12414 nummod 95,%
R10727 T12414 T12416 compound %,]
R10728 T12415 T12416 compound CI,]
R10729 T12416 T12409 appos ],manner
R10730 T12417 T12416 punct ",",]
R10731 T12418 T12420 nummod 0.0032,0.0026
R10732 T12419 T12420 compound [,0.0026
R10733 T12420 T12416 appos 0.0026,]
R10734 T12421 T12422 nummod 0.0039,]
R10735 T12422 T12416 conj ],]
R10736 T12423 T12422 cc versus,]
R10737 T12424 T12426 compound 0.658,0.592
R10738 T12425 T12426 compound [,0.592
R10739 T12426 T12416 appos 0.592,]
R10740 T12427 T12428 nummod 0.720,]
R10741 T12428 T12416 appos ],]
R10742 T12429 T12428 punct ",",]
R10743 T12430 T12431 compound p,<
R10744 T12431 T12432 compound <,0.05
R10745 T12432 T12428 appos 0.05,]
R10746 T12433 T12428 punct ",",]
R10747 T12434 T12428 amod W,]
R10748 T12435 T12416 punct =,]
R10749 T12436 T12416 punct −,]
R10750 T12437 T12416 appos 21.00,]
R10751 T12438 T12416 punct ",",]
R10752 T12439 T12442 poss Wilcoxon,test
R10753 T12440 T12439 case 's,Wilcoxon
R10754 T12441 T12442 compound rank,test
R10755 T12442 T12416 appos test,]
R10756 T12443 T12416 punct ),]
R10757 T12444 T12446 punct (,7D
R10758 T12445 T12446 compound Figure,7D
R10759 T12446 T12416 appos 7D,]
R10760 T12447 T12416 punct ),]
R10761 T12448 T12345 punct .,inhaled
R10762 T12449 T12457 prep In,inhibited
R10763 T12450 T12449 pobj addition,In
R10764 T12451 T12457 punct ",",inhibited
R10765 T12452 T12457 nsubj FP,inhibited
R10766 T12453 T12455 punct (,µg
R10767 T12454 T12455 nummod 500,µg
R10768 T12455 T12452 appos µg,FP
R10769 T12456 T12455 punct ),µg
R10770 T12457 T12457 ROOT inhibited,inhibited
R10771 T12458 T12460 nummod p38,phosphorylation
R10772 T12459 T12460 compound MAPK,phosphorylation
R10773 T12460 T12457 dobj phosphorylation,inhibited
R10774 T12461 T12460 prep in,phosphorylation
R10775 T12462 T12464 amod primary,cells
R10812 T12499 T12498 dobj phospho-GATA-3,inhibiting
R10813 T12500 T12501 compound importin,association
R10814 T12501 T12498 npadvmod association,inhibiting
R10815 T12502 T12485 punct .,suggest
R10816 T12503 T12504 det This,effect
R10817 T12504 T12506 nsubj effect,be
R10818 T12505 T12506 aux may,be
R10819 T12506 T12506 ROOT be,be
R10820 T12507 T12506 acomp direct,be
R10821 T12508 T12507 punct ",",direct
R10822 T12509 T12506 prep through,be
R10823 T12510 T12509 pobj competition,through
R10824 T12511 T12510 prep for,competition
R10825 T12512 T12515 amod importin-α,molecules
R10826 T12513 T12512 cc or,importin-α
R10827 T12514 T12512 conj associated,importin-α
R10828 T12515 T12511 pobj molecules,for
R10829 T12516 T12515 punct ",",molecules
R10830 T12517 T12510 cc or,competition
R10831 T12518 T12510 conj secondary,competition
R10832 T12519 T12518 prep to,secondary
R10833 T12520 T12521 det an,effect
R10834 T12521 T12519 pobj effect,to
R10835 T12522 T12521 prep on,effect
R10836 T12523 T12526 nummod p38,phosphorylation
R10837 T12524 T12526 nmod MAPK-mediated,phosphorylation
R10838 T12525 T12526 amod GATA-3,phosphorylation
R10839 T12526 T12522 pobj phosphorylation,on
R10840 T12527 T12506 prep via,be
R10841 T12528 T12529 amod rapid,induction
R10842 T12529 T12527 pobj induction,via
R10843 T12530 T12529 prep of,induction
R10844 T12531 T12530 pobj MKP-1,of
R10845 T12532 T12506 punct .,be
R10846 T12533 T12534 det The,combination
R10847 T12534 T12541 nsubj combination,result
R10848 T12535 T12534 prep of,combination
R10849 T12536 T12539 det these,effects
R10850 T12537 T12539 nummod two,effects
R10851 T12538 T12539 amod interacting,effects
R10852 T12539 T12535 pobj effects,of
R10853 T12540 T12541 aux can,result
R10854 T12541 T12541 ROOT result,result
R10855 T12542 T12541 prep in,result
R10856 T12543 T12544 amod complete,suppression
R10857 T12544 T12542 pobj suppression,in
R10858 T12545 T12544 prep of,suppression
R10859 T12546 T12554 amod GATA-3,expression
R10860 T12547 T12548 amod nuclear,import
R10861 T12548 T12554 nmod import,expression
R10862 T12549 T12548 cc and,import
R10863 T12550 T12554 advmod thus,expression
R10864 T12551 T12554 amod Th2,expression
R10865 T12552 T12554 amod cytokine,expression
R10866 T12553 T12554 compound gene,expression
R10867 T12554 T12545 pobj expression,of
R10868 T12555 T12541 punct .,result
R14001 T16315 T16317 nmod Fluticasone,down-regulates
R14002 T16316 T16317 amod propionate,down-regulates
R14003 T16317 T16317 ROOT down-regulates,down-regulates
R14004 T16318 T16321 nmod Th2,expression
R14005 T16319 T16321 compound cytokine,expression
R14006 T16320 T16321 compound gene,expression
R14007 T16321 T16317 dobj expression,down-regulates
R14008 T16322 T16321 cc and,expression
R14009 T16323 T16317 conj inhibits,down-regulates
R14010 T16324 T16326 nmod GATA-3,import
R14011 T16325 T16326 amod nuclear,import
R14012 T16326 T16323 dobj import,inhibits
R14013 T16327 T16323 punct .,inhibits
R14014 T16328 T16329 punct (,A
R14015 T16329 T16329 ROOT A,A
R14016 T16330 T16329 punct ),A
R14017 T16331 T16334 amod Anti-CD3,treatment
R14018 T16332 T16334 nmod /,treatment
R14019 T16333 T16334 nummod CD28,treatment
R14020 T16334 T16334 ROOT treatment,treatment
R14021 T16335 T16334 prep of,treatment
R14022 T16336 T16337 amod HuT-78,cells
R14023 T16337 T16338 compound cells,results
R14024 T16338 T16335 pobj results,of
R14025 T16339 T16338 prep in,results
R14026 T16340 T16339 pobj translocation,in
R14027 T16341 T16340 prep of,translocation
R14028 T16342 T16341 pobj GATA-3,of
R14029 T16343 T16334 prep from,treatment
R14030 T16344 T16345 det the,cytoplasm
R14031 T16345 T16343 pobj cytoplasm,from
R14032 T16346 T16334 prep to,treatment
R14033 T16347 T16348 det the,nucleus
R14034 T16348 T16346 pobj nucleus,to
R14035 T16349 T16334 prep within,treatment
R14036 T16350 T16351 nummod 30,min
R14037 T16351 T16349 pobj min,within
R14038 T16352 T16334 punct .,treatment
R14039 T16353 T16361 punct (,used
R14040 T16354 T16361 nsubjpass B,used
R14041 T16355 T16354 punct ),B
R14042 T16356 T16357 compound Histone,H1
R14043 T16357 T16354 appos H1,B
R14044 T16358 T16357 cc and,H1
R14045 T16359 T16357 conj MEK-1,H1
R14046 T16360 T16361 auxpass were,used
R14047 T16361 T16361 ROOT used,used
R14048 T16362 T16363 aux to,confirm
R14049 T16363 T16361 xcomp confirm,used
R14050 T16364 T16365 amod distinct,separation
R14051 T16365 T16363 dobj separation,confirm
R14052 T16366 T16365 prep of,separation
R14053 T16367 T16370 amod cytoplasmic,extracts
R14054 T16368 T16367 cc and,cytoplasmic
R14055 T16369 T16367 conj nuclear,cytoplasmic
R14056 T16370 T16366 pobj extracts,of
R14057 T16371 T16363 prep in,confirm
R14058 T16372 T16374 nummod three,experiments
R14059 T16373 T16374 amod separate,experiments
R14060 T16374 T16371 pobj experiments,in
R14061 T16375 T16361 punct .,used
R14062 T16376 T16377 punct (,C
R14063 T16377 T16381 nmod C,analysis
R14064 T16378 T16377 punct ),C
R14065 T16379 T16381 amod Western,analysis
R14066 T16380 T16381 compound blot,analysis
R14067 T16381 T16386 nsubj analysis,demonstrated
R14068 T16382 T16381 prep of,analysis
R14069 T16383 T16385 amod FP-treated,cells
R14070 T16384 T16385 amod HuT-78,cells
R14071 T16385 T16382 pobj cells,of
R14072 T16386 T16386 ROOT demonstrated,demonstrated
R14073 T16387 T16389 amod impaired,localization
R14074 T16388 T16389 amod nuclear,localization
R14075 T16389 T16386 dobj localization,demonstrated
R14076 T16390 T16389 prep of,localization
R14077 T16391 T16390 pobj GATA-3,of
R14078 T16392 T16389 acl induced,localization
R14079 T16393 T16392 agent by,induced
R14080 T16394 T16397 amod anti-CD3,co-stimulation
R14081 T16395 T16397 nmod /,co-stimulation
R14082 T16396 T16397 nummod CD28,co-stimulation
R14083 T16397 T16393 pobj co-stimulation,by
R14084 T16398 T16392 prep in,induced
R14085 T16399 T16400 det a,time
R14086 T16400 T16398 pobj time,in
R14087 T16401 T16389 punct -,localization
R14088 T16402 T16389 punct (,localization
R14089 T16403 T16389 prep at,localization
R14090 T16404 T16405 nummod 10,−
R14091 T16405 T16408 nmod −,FP
R14092 T16406 T16408 nummod 8,FP
R14093 T16407 T16408 compound M,FP
R14094 T16408 T16403 pobj FP,at
R14095 T16409 T16389 punct ),localization
R14096 T16410 T16389 cc and,localization
R14097 T16411 T16389 conj concentration,localization
R14098 T16412 T16389 punct -,localization
R14099 T16413 T16389 punct (,localization
R14100 T16414 T16386 prep at,demonstrated
R14101 T16415 T16416 nummod 60,min
R14102 T16416 T16414 pobj min,at
R14103 T16417 T16416 prep after,min
R14104 T16418 T16417 pobj stimulation,after
R14105 T16419 T16386 punct ),demonstrated
R14106 T16420 T16421 amod dependent,manner
R14107 T16421 T16421 ROOT manner,manner
R14108 T16422 T16421 punct .,manner
R14109 T16423 T16425 nsubjpass Cells,pretreated
R14110 T16424 T16425 auxpass were,pretreated
R14111 T16425 T16425 ROOT pretreated,pretreated
R14112 T16426 T16425 prep with,pretreated
R14113 T16427 T16426 pobj FP,with
R14114 T16428 T16425 prep for,pretreated
R14115 T16429 T16430 nummod 30,min
R14116 T16430 T16428 pobj min,for
R14117 T16431 T16425 advmod prior,pretreated
R14118 T16432 T16431 prep to,prior
R14119 T16433 T16432 pobj stimulation,to
R14120 T16434 T16425 punct .,pretreated
R14121 T16435 T16440 nsubjpass MEK1,used
R14122 T16436 T16435 cc and,MEK1
R14123 T16437 T16438 compound histone,H1
R14124 T16438 T16435 conj H1,MEK1
R14125 T16439 T16440 auxpass were,used
R14126 T16440 T16440 ROOT used,used
R14127 T16441 T16442 aux to,demonstrate
R14128 T16442 T16440 xcomp demonstrate,used
R14129 T16443 T16444 amod equal,cytoplasmic
R14130 T16444 T16442 dobj cytoplasmic,demonstrate
R14131 T16445 T16444 cc and,cytoplasmic
R14132 T16446 T16444 conj nuclear,cytoplasmic
R14133 T16447 T16442 advcl loading,demonstrate
R14134 T16448 T16447 advmod respectively,loading
R14135 T16449 T16440 punct .,used
R14136 T16450 T16452 nsubjpass Results,presented
R14137 T16451 T16452 auxpass are,presented
R14138 T16452 T16452 ROOT presented,presented
R14139 T16453 T16454 advmod graphically,below
R14140 T16454 T16452 prep below,presented
R14141 T16455 T16452 prep as,presented
R14142 T16456 T16458 amod mean,SEM
R14143 T16457 T16458 compound ±,SEM
R14144 T16458 T16455 pobj SEM,as
R14145 T16459 T16458 prep of,SEM
R14146 T16460 T16461 advmod at,least
R14147 T16461 T16462 advmod least,three
R14148 T16462 T16464 nummod three,experiments
R14149 T16463 T16464 amod independent,experiments
R14150 T16464 T16459 pobj experiments,of
R14151 T16465 T16452 punct .,presented
R14152 T16466 T16468 compound ***,<
R14153 T16467 T16468 compound p,<
R14154 T16468 T16470 nsubj <,compared
R14155 T16469 T16468 nummod 0.001,<
R14156 T16470 T16470 ROOT compared,compared
R14157 T16471 T16470 prep to,compared
R14158 T16472 T16471 pobj t,to
R14159 T16473 T16474 punct =,0
R14160 T16474 T16472 prep 0,t
R14161 T16475 T16470 punct .,compared
R14162 T16476 T16479 punct (,RT-PCR
R14163 T16477 T16479 nmod D,RT-PCR
R14164 T16478 T16479 punct ),RT-PCR
R14165 T16479 T16479 ROOT RT-PCR,RT-PCR
R14166 T16480 T16479 acl showing,RT-PCR
R14167 T16481 T16483 mark that,inhibits
R14168 T16482 T16483 nsubj FP,inhibits
R14169 T16483 T16480 ccomp inhibits,showing
R14170 T16484 T16488 nmod IL-4,expression
R14171 T16485 T16484 cc and,IL-4
R14172 T16486 T16484 conj IL-5,IL-4
R14173 T16487 T16488 compound mRNA,expression
R14174 T16488 T16483 dobj expression,inhibits
R14175 T16489 T16488 prep in,expression
R14176 T16490 T16491 amod CD3/CD28-costimulated,cells
R14177 T16491 T16489 pobj cells,in
R14178 T16492 T16479 punct .,RT-PCR
R14179 T16493 T16495 nsubjpass GAPDH,used
R14180 T16494 T16495 auxpass was,used
R14181 T16495 T16495 ROOT used,used
R14182 T16496 T16495 prep as,used
R14183 T16497 T16499 det a,control
R14184 T16498 T16499 compound loading,control
R14185 T16499 T16496 pobj control,as
R14186 T16500 T16495 punct .,used
R14187 T16501 T16502 amod Lower,panels
R14188 T16502 T16503 nsubj panels,show
R14189 T16503 T16503 ROOT show,show
R14190 T16504 T16505 amod graphical,analysis
R14191 T16505 T16503 dobj analysis,show
R14192 T16506 T16505 prep of,analysis
R14193 T16507 T16506 pobj results,of
R14194 T16508 T16507 acl presented,results
R14196 T16510 T16512 amod mean,SEM
R14197 T16511 T16512 compound ±,SEM
R14198 T16512 T16509 pobj SEM,as
R14199 T16513 T16512 prep of,SEM
R14200 T16514 T16515 advmod at,least
R14201 T16515 T16516 advmod least,three
R14202 T16516 T16518 nummod three,experiments
R14203 T16517 T16518 amod independent,experiments
R14204 T16518 T16513 pobj experiments,of
R14205 T16519 T16503 punct .,show
R14206 T16520 T16522 dep ###,<
R14207 T16521 T16522 nmod p,<
R14208 T16522 T16522 ROOT <,<
R14209 T16523 T16532 nsubj 0.001,compared
R14210 T16524 T16532 prep compared,compared
R14211 T16525 T16526 aux to,control
R14212 T16526 T16524 xcomp control,compared
R14213 T16527 T16532 punct ",",compared
R14214 T16528 T16531 nmod ***,0.001
R14215 T16529 T16531 nmod p,0.001
R14216 T16530 T16531 nmod <,0.001
R14217 T16531 T16532 nsubj 0.001,compared
R14218 T16532 T16532 ROOT compared,compared
R14219 T16533 T16532 prep to,compared
R14220 T16534 T16535 compound anti-CD3,/
R14221 T16535 T16536 compound /,CD28
R14222 T16536 T16533 pobj CD28,to
R14223 T16537 T16536 acl stimulated,CD28
R14224 T16538 T16532 punct .,compared
R14225 T16539 T16542 punct (,FP
R14226 T16540 T16542 nmod E,FP
R14227 T16541 T16542 punct ),FP
R14228 T16542 T16547 nsubj FP,reduces
R14229 T16543 T16545 punct (,nM
R14230 T16544 T16545 nummod 10,nM
R14231 T16545 T16542 appos nM,FP
R14232 T16546 T16542 punct ),FP
R14233 T16547 T16547 ROOT reduces,reduces
R14234 T16548 T16549 det the,ability
R14235 T16549 T16547 dobj ability,reduces
R14236 T16550 T16549 prep of,ability
R14237 T16551 T16554 amod anti-CD3,GATA-3
R14238 T16552 T16554 nmod /,GATA-3
R14239 T16553 T16554 amod CD28-stimulated,GATA-3
R14240 T16554 T16550 pobj GATA-3,of
R14241 T16555 T16556 aux to,associate
R14242 T16556 T16549 acl associate,ability
R14243 T16557 T16556 prep with,associate
R14244 T16558 T16561 det the,promoter
R14245 T16559 T16561 amod native,promoter
R14246 T16560 T16561 compound IL-5,promoter
R14247 T16561 T16557 pobj promoter,with
R14248 T16562 T16563 nummod 60,min
R14249 T16563 T16561 appos min,promoter
R14250 T16564 T16563 prep after,min
R14251 T16565 T16564 pobj stimulation,after
R14252 T16566 T16547 punct .,reduces
R14253 T16567 T16570 nsubjpass Data,shown
R14254 T16568 T16570 auxpass are,shown
R14255 T16569 T16570 advmod also,shown
R14256 T16570 T16570 ROOT shown,shown
R14257 T16571 T16570 advmod graphically,shown
R14258 T16572 T16570 prep as,shown
R14259 T16573 T16575 amod mean,SEM
R14260 T16574 T16575 compound ±,SEM
R14261 T16575 T16572 pobj SEM,as
R14262 T16576 T16575 prep of,SEM
R14263 T16577 T16579 nummod three,experiments
R14264 T16578 T16579 amod independent,experiments
R14265 T16579 T16576 pobj experiments,of
R14266 T16580 T16570 punct .,shown
R14267 T16581 T16582 det All,data
R14268 T16582 T16584 nsubjpass data,analysed
R14269 T16583 T16584 auxpass were,analysed
R14270 T16584 T16584 ROOT analysed,analysed
R14271 T16585 T16584 agent by,analysed
R14272 T16586 T16585 pobj ANOVA,by
R14273 T16587 T16584 acl followed,analysed
R14274 T16588 T16587 agent by,followed
R14275 T16589 T16588 pobj Newman-Keuls,by
R14276 T16590 T16590 ROOT post-test,post-test
R14277 T16591 T16584 punct .,analysed
R14667 T17105 T17106 compound Fluticasone,propionate
R14668 T17106 T17107 nsubj propionate,reduces
R14669 T17107 T17107 ROOT reduces,reduces
R14670 T17108 T17109 amod GATA-3,association
R14671 T17109 T17107 dobj association,reduces
R14672 T17110 T17109 prep with,association
R14673 T17111 T17115 amod importin-α,import
R14674 T17112 T17111 cc and,importin-α
R14675 T17113 T17111 conj GATA-3,importin-α
R14676 T17114 T17115 amod nuclear,import
R14677 T17115 T17110 pobj import,with
R14678 T17116 T17107 punct .,reduces
R14679 T17117 T17118 punct (,A
R14680 T17118 T17122 nmod A,analysis
R14681 T17119 T17118 punct ),A
R14682 T17120 T17122 amod Western,analysis
R14683 T17121 T17122 compound blot,analysis
R14684 T17122 T17123 nsubj analysis,demonstrates
R14685 T17123 T17123 ROOT demonstrates,demonstrates
R14686 T17124 T17133 det a,FP
R14687 T17125 T17133 nmod time,FP
R14688 T17126 T17133 punct -,FP
R14689 T17127 T17133 punct (,FP
R14690 T17128 T17133 prep at,FP
R14691 T17129 T17131 quantmod 10,8
R14692 T17130 T17131 quantmod −,8
R14718 T17156 T17123 punct .,demonstrates
R14719 T17157 T17159 det A,control
R14720 T17158 T17159 amod positive,control
R14721 T17159 T17166 nsubjpass control,shown
R14722 T17160 T17159 prep for,control
R14723 T17161 T17162 compound GR,association
R14724 T17162 T17160 pobj association,for
R14725 T17163 T17162 prep with,association
R14726 T17164 T17163 pobj importin,with
R14727 T17165 T17166 auxpass is,shown
R14728 T17166 T17166 ROOT shown,shown
R14729 T17167 T17166 punct .,shown
R14730 T17168 T17174 nsubjpass Quantification,shown
R14731 T17169 T17168 prep of,Quantification
R14732 T17170 T17172 det the,data
R14733 T17171 T17172 compound densitometry,data
R14734 T17172 T17169 pobj data,of
R14735 T17173 T17174 auxpass is,shown
R14736 T17174 T17174 ROOT shown,shown
R14737 T17175 T17174 prep below,shown
R14738 T17176 T17174 punct .,shown
R14739 T17177 T17178 det Each,bar
R14740 T17178 T17179 nsubj bar,represents
R14741 T17179 T17179 ROOT represents,represents
R14742 T17180 T17182 amod mean,SEM
R14743 T17181 T17182 compound ±,SEM
R14744 T17182 T17179 dobj SEM,represents
R14745 T17183 T17182 prep of,SEM
R14796 T17234 T17237 amod FP-activated,translocation
R14797 T17235 T17237 nmod GR,translocation
R14798 T17236 T17237 amod nuclear,translocation
R14799 T17237 T17238 npadvmod translocation,measured
R14800 T17238 T17232 acl measured,induction
R14801 T17239 T17238 agent by,measured
R14802 T17240 T17239 pobj IP,by
R14803 T17241 T17209 punct .,demonstrated
R14804 T17242 T17248 nsubjpass Quantification,shown
R14805 T17243 T17242 prep of,Quantification
R14806 T17244 T17246 det the,data
R14807 T17245 T17246 compound densitometry,data
R14808 T17246 T17243 pobj data,of
R14809 T17247 T17248 auxpass is,shown
R14810 T17248 T17248 ROOT shown,shown
R14811 T17249 T17248 prep below,shown
R14812 T17250 T17248 punct .,shown
R14813 T17251 T17252 det Each,bar
R14814 T17252 T17253 nsubj bar,represents
R14815 T17253 T17253 ROOT represents,represents
R14816 T17254 T17256 amod mean,SEM
R14817 T17255 T17256 compound ±,SEM
R14818 T17256 T17253 dobj SEM,represents
R14819 T17257 T17256 prep of,SEM
R14820 T17258 T17259 advmod at,least
R14821 T17259 T17260 advmod least,three
R14822 T17260 T17262 nummod three,experiments
R14823 T17261 T17262 amod independent,experiments
R14849 T17287 T17288 nummod CD28,co-stimulation
R14850 T17288 T17289 nsubj co-stimulation,demonstrated
R14851 T17289 T17289 ROOT demonstrated,demonstrated
R14852 T17290 T17292 det a,decrease
R14853 T17291 T17292 amod concentration-dependent,decrease
R14854 T17292 T17289 dobj decrease,demonstrated
R14855 T17293 T17292 prep in,decrease
R14856 T17294 T17293 pobj GATA-3,in
R14857 T17295 T17296 compound importin-α,association
R14858 T17296 T17292 appos association,decrease
R14859 T17297 T17292 prep at,decrease
R14860 T17298 T17299 nummod 20,min
R14861 T17299 T17297 pobj min,at
R14862 T17300 T17289 punct .,demonstrated
R14863 T17301 T17307 nsubjpass Quantification,shown
R14864 T17302 T17301 prep of,Quantification
R14865 T17303 T17305 det the,data
R14866 T17304 T17305 compound densitometry,data
R14867 T17305 T17302 pobj data,of
R14868 T17306 T17307 auxpass is,shown
R14869 T17307 T17307 ROOT shown,shown
R14870 T17308 T17307 prep below,shown
R14871 T17309 T17307 punct .,shown
R14872 T17310 T17311 det Each,bar
R14873 T17311 T17312 nsubj bar,represents
R14874 T17312 T17312 ROOT represents,represents
R14875 T17313 T17315 amod mean,SEM
R14876 T17314 T17315 compound ±,SEM
R14877 T17315 T17312 dobj SEM,represents
R14878 T17316 T17315 prep of,SEM
R14879 T17317 T17318 advmod at,least
R14880 T17318 T17319 advmod least,three
R14881 T17319 T17321 nummod three,experiments
R14882 T17320 T17321 amod independent,experiments
R14883 T17321 T17316 pobj experiments,of
R14884 T17322 T17312 punct .,represents
R14885 T17323 T17325 dep ###,<
R14886 T17324 T17325 compound p,<
R14887 T17325 T17325 ROOT <,<
R14888 T17326 T17326 ROOT 0.001,0.001
R14889 T17327 T17335 prep compared,compared
R14890 T17328 T17329 aux to,control
R14891 T17329 T17327 xcomp control,compared
R14892 T17330 T17333 punct ",",<
R14893 T17331 T17333 nmod ***,<
R14894 T17332 T17333 nmod p,<
R14895 T17333 T17334 nmod <,0.001
R14896 T17334 T17335 npadvmod 0.001,compared
R14897 T17335 T17326 prep compared,0.001
R14898 T17336 T17335 prep to,compared
R14899 T17337 T17336 pobj αCD3,to
R14900 T17338 T17340 amod /,cells
R14901 T17339 T17340 amod CD28-stimulated,cells
R14902 T17340 T17337 dobj cells,αCD3
R14903 T17341 T17326 punct .,0.001
R14904 T17342 T17343 punct (,D
R14905 T17343 T17343 ROOT D,D
R14906 T17344 T17343 punct ),D
R14907 T17345 T17346 amod GFP-tagged,GATA-3
R14908 T17346 T17348 nsubjpass GATA-3,overexpressed
R14909 T17347 T17348 auxpass was,overexpressed
R14910 T17348 T17348 ROOT overexpressed,overexpressed
R14911 T17349 T17348 cc and,overexpressed
R14912 T17350 T17348 conj cells,overexpressed
R14913 T17351 T17350 acl stimulated,cells
R14914 T17352 T17355 punct (,c
R14915 T17353 T17355 nmod b,c
R14916 T17354 T17355 punct ",",c
R14917 T17355 T17351 appos c,stimulated
R14918 T17356 T17355 punct ),c
R14919 T17357 T17355 cc or,c
R14920 T17358 T17359 neg not,(
R14921 T17359 T17360 punct (,a
R14922 T17360 T17362 meta a,for
R14923 T17361 T17360 punct ),a
R14924 T17362 T17355 conj for,c
R14925 T17363 T17364 nummod 30,min
R14926 T17364 T17362 pobj min,for
R14927 T17365 T17364 prep with,min
R14928 T17366 T17367 compound anti-CD3,/
R14929 T17367 T17368 compound /,CD28
R14930 T17368 T17365 pobj CD28,with
R14931 T17369 T17348 punct .,overexpressed
R14932 T17370 T17371 det The,effect
R14933 T17371 T17390 nsubjpass effect,shown
R14934 T17372 T17371 prep of,effect
R14935 T17373 T17375 nummod 30,pretreatment
R14936 T17374 T17375 compound min,pretreatment
R14937 T17375 T17372 pobj pretreatment,of
R14938 T17376 T17375 prep of,pretreatment
R14939 T17377 T17376 pobj cells,of
R14940 T17378 T17371 prep with,effect
R14941 T17379 T17378 pobj FP,with
R14942 T17380 T17379 punct (,FP
R14943 T17381 T17382 nummod 10,−
R14944 T17382 T17379 appos −,FP
R14945 T17383 T17384 nummod 8,M
R14946 T17384 T17390 nsubjpass M,shown
R14947 T17385 T17384 punct ",",M
R14948 T17386 T17384 appos c,M
R14949 T17387 T17384 punct ),M
R14950 T17388 T17390 auxpass is,shown
R14951 T17389 T17390 advmod also,shown
R14952 T17390 T17390 ROOT shown,shown
R14953 T17391 T17390 punct .,shown
R14954 T17392 T17393 det All,data
R14955 T17393 T17395 nsubjpass data,analysed
R14956 T17394 T17395 auxpass were,analysed
R14957 T17395 T17395 ROOT analysed,analysed
R14958 T17396 T17395 agent by,analysed
R14959 T17397 T17396 pobj ANOVA,by
R14960 T17398 T17395 prep followed,analysed
R14961 T17399 T17398 agent by,followed
R14962 T17400 T17399 pobj Newman-Keuls,by
R14963 T17401 T17395 conj post-test,analysed
R14964 T17402 T17395 punct .,analysed
R15301 T17853 T17854 compound Fluticasone,propionate
R15302 T17854 T17854 ROOT propionate,propionate
R15303 T17855 T17865 nsubjpass mediated,associated
R15304 T17856 T17855 dobj inhibition,mediated
R15305 T17857 T17856 prep of,inhibition
R15306 T17858 T17861 nummod p38,phosphorylation
R15307 T17859 T17861 nmod MAP,phosphorylation
R15308 T17860 T17861 compound kinase,phosphorylation
R15309 T17861 T17857 pobj phosphorylation,of
R15310 T17862 T17861 cc and,phosphorylation
R15311 T17863 T17861 conj activation,phosphorylation
R15312 T17864 T17865 auxpass is,associated
R15313 T17865 T17865 ROOT associated,associated
R15314 T17866 T17865 prep with,associated
R15315 T17867 T17869 det a,down-regulation
R15316 T17868 T17869 amod marked,down-regulation
R15317 T17869 T17866 pobj down-regulation,with
R15318 T17870 T17869 prep of,down-regulation
R15319 T17871 T17873 amod GATA-3,phosphorylation
R15320 T17872 T17873 compound serine,phosphorylation
R15321 T17873 T17870 pobj phosphorylation,of
R15322 T17874 T17865 punct .,associated
R15323 T17875 T17876 punct (,A
R15324 T17876 T17880 nmod A,analysis
R15325 T17877 T17876 punct ),A
R15326 T17878 T17880 amod Western,analysis
R15327 T17879 T17880 compound blot,analysis
R15328 T17880 T17881 nsubj analysis,shows
R15329 T17881 T17881 ROOT shows,shows
R15330 T17882 T17894 mark that,reduced
R15331 T17883 T17888 nmod FP,M
R15332 T17884 T17886 punct (,−
R15333 T17885 T17886 nummod 10,−
R15334 T17886 T17883 appos −,FP
R15335 T17887 T17888 nummod 8,M
R15336 T17888 T17894 nsubj M,reduced
R15337 T17889 T17888 punct ",",M
R15338 T17890 T17891 nummod 30,min
R15339 T17891 T17888 appos min,M
R15340 T17892 T17891 punct ),min
R15341 T17893 T17894 nsubj treatment,reduced
R15342 T17894 T17881 ccomp reduced,shows
R15343 T17895 T17896 amod dual,phosphorylation
R15344 T17896 T17894 dobj phosphorylation,reduced
R15345 T17897 T17898 punct (,threonine-180
R15346 T17898 T17896 appos threonine-180,phosphorylation
R15347 T17899 T17898 cc and,threonine-180
R15348 T17900 T17898 conj tyrosine-182,threonine-180
R15349 T17901 T17898 punct ),threonine-180
R15350 T17902 T17896 prep of,phosphorylation
R15351 T17903 T17904 nummod p38,MAPK
R15352 T17904 T17902 pobj MAPK,of
R15353 T17905 T17904 prep in,MAPK
R15354 T17906 T17907 compound anti-CD3,/
R15355 T17907 T17905 pobj /,in
R15356 T17908 T17907 nummod CD28,/
R15357 T17909 T17911 amod co-stimulated,cells
R15358 T17910 T17911 amod HuT-78,cells
R15359 T17911 T17896 appos cells,phosphorylation
R15360 T17912 T17881 punct .,shows
R15361 T17913 T17917 punct (,course
R15362 T17914 T17917 compound B,course
R15363 T17915 T17916 punct ),Time
R15364 T17916 T17917 compound Time,course
R15365 T17917 T17917 ROOT course,course
R15366 T17918 T17917 prep of,course
R15367 T17919 T17920 det the,effect
R15368 T17920 T17918 pobj effect,of
R15369 T17921 T17920 prep of,effect
R15370 T17922 T17921 pobj FP,of
R15371 T17923 T17922 punct (,FP
R15372 T17924 T17926 quantmod 10,8
R15373 T17925 T17926 quantmod −,8
R15374 T17926 T17927 npadvmod 8,M
R15375 T17927 T17922 appos M,FP
R15376 T17928 T17922 punct ),FP
R15377 T17929 T17920 prep on,effect
R15378 T17930 T17929 pobj phosphorylation,on
R15379 T17931 T17930 prep of,phosphorylation
R15380 T17932 T17934 amod activated,factor
R15381 T17933 T17934 compound transcription,factor
R15382 T17934 T17931 pobj factor,of
R15383 T17935 T17934 nummod 2,factor
R15384 T17936 T17937 punct (,ATF-2
R15385 T17937 T17934 appos ATF-2,factor
R15386 T17938 T17937 punct ),ATF-2
R15387 T17939 T17937 punct ",",ATF-2
R15388 T17940 T17941 det a,measure
R15389 T17941 T17937 appos measure,ATF-2
R15390 T17942 T17941 prep of,measure
R15391 T17943 T17945 nummod p38,activity
R15392 T17944 T17945 compound MAPK,activity
R15393 T17945 T17942 pobj activity,of
R15394 T17946 T17917 punct .,course
R15395 T17947 T17948 punct (,C
R15396 T17948 T17951 nmod C,inhibition
R15397 T17949 T17948 punct ),C
R15398 T17950 T17951 amod FP-induced,inhibition
R15399 T17951 T17957 nsubjpass inhibition,associated
R15400 T17952 T17951 prep of,inhibition
R15401 T17953 T17955 nummod p38,activity
R15402 T17954 T17955 compound MAPK,activity
R15403 T17955 T17952 pobj activity,of
R15404 T17956 T17957 auxpass is,associated
R15405 T17957 T17957 ROOT associated,associated
R15406 T17958 T17957 prep with,associated
R15407 T17959 T17960 det the,decrease
R15408 T17960 T17958 pobj decrease,with
R15409 T17961 T17960 prep of,decrease
R15410 T17962 T17966 dep anti-CD3,induced
R15411 T17963 T17966 dep /,induced
R15412 T17964 T17965 nummod CD28,co-stimulation
R15413 T17965 T17963 appos co-stimulation,/
R15414 T17966 T17957 advcl induced,associated
R15415 T17967 T17968 amod serine,phosphorylation
R15416 T17968 T17966 dobj phosphorylation,induced
R15417 T17969 T17970 punct (,P-Ser
R15418 T17970 T17968 appos P-Ser,phosphorylation
R15419 T17971 T17970 punct ),P-Ser
R15420 T17972 T17968 prep of,phosphorylation
R15421 T17973 T17972 pobj GATA-3,of
R15422 T17974 T17966 punct .,induced
R15423 T17975 T17988 prep For,shown
R15424 T17976 T17977 punct (,A
R15425 T17977 T17978 det A,C
R15426 T17978 T17975 pobj C,For
R15427 T17979 T17978 punct ),C
R15428 T17980 T17988 punct ",",shown
R15429 T17981 T17988 nsubjpass quantification,shown
R15430 T17982 T17981 prep of,quantification
R15431 T17983 T17985 det the,data
R15432 T17984 T17985 compound densitometry,data
R15433 T17985 T17982 pobj data,of
R15434 T17986 T17988 auxpass is,shown
R15435 T17987 T17988 advmod also,shown
R15436 T17988 T17988 ROOT shown,shown
R15437 T17989 T17988 punct .,shown
R15438 T17990 T17991 det Each,bar
R15439 T17991 T17992 nsubj bar,represents
R15440 T17992 T17992 ROOT represents,represents
R15441 T17993 T17995 amod mean,SEM
R15442 T17994 T17995 compound ±,SEM
R15443 T17995 T17992 dobj SEM,represents
R15444 T17996 T17995 prep of,SEM
R15445 T17997 T17998 advmod at,least
R15446 T17998 T17999 advmod least,three
R15447 T17999 T18001 nummod three,experiments
R15448 T18000 T18001 amod independent,experiments
R15449 T18001 T17996 pobj experiments,of
R15450 T18002 T17992 punct .,represents
R15451 T18003 T18005 dep ###,<
R15452 T18004 T18005 compound p,<
R15453 T18005 T18005 ROOT <,<
R15454 T18006 T18015 nsubj 0.001,compared
R15455 T18007 T18015 prep compared,compared
R15456 T18008 T18009 aux to,control
R15457 T18009 T18007 xcomp control,compared
R15458 T18010 T18015 punct ",",compared
R15459 T18011 T18013 nmod ***,<
R15460 T18012 T18013 nmod p,<
R15461 T18013 T18014 nmod <,0.001
R15462 T18014 T18015 nsubj 0.001,compared
R15463 T18015 T18015 ROOT compared,compared
R15464 T18016 T18015 prep to,compared
R15465 T18017 T18016 pobj αCD3,to
R15466 T18018 T18020 amod /,cells
R15467 T18019 T18020 amod CD28-stimulated,cells
R15468 T18020 T18017 dobj cells,αCD3
R15469 T18021 T18015 punct .,compared
R15470 T18022 T18026 punct (,induced
R15471 T18023 T18025 nmod D,FP
R15472 T18024 T18025 punct ),FP
R15473 T18025 T18026 nsubj FP,induced
R15474 T18026 T18026 ROOT induced,induced
R15475 T18027 T18028 compound MKP-1,mRNA
R15476 T18028 T18026 dobj mRNA,induced
R15477 T18029 T18026 prep in,induced
R15478 T18030 T18032 det a,manner
R15479 T18031 T18032 amod concentration-dependent,manner
R15480 T18032 T18029 pobj manner,in
R15481 T18033 T18026 punct .,induced
R15482 T18034 T18035 det All,results
R15483 T18035 T18036 nsubj results,are
R15484 T18036 T18036 ROOT are,are
R15485 T18037 T18036 attr representative,are
R15486 T18038 T18037 prep of,representative
R15487 T18039 T18040 advmod at,least
R15488 T18040 T18041 advmod least,three
R15489 T18041 T18043 nummod three,experiments
R15490 T18042 T18043 amod independent,experiments
R15491 T18043 T18038 pobj experiments,of
R15492 T18044 T18043 cc and,experiments
R15493 T18045 T18047 advmod where,expressed
R15494 T18046 T18047 amod appropriate,expressed
R15495 T18047 T18037 relcl expressed,representative
R15496 T18048 T18047 prep as,expressed
R15521 T18073 T18072 prep of,representative
R15522 T18074 T18076 nummod two,experiments
R15523 T18075 T18076 amod independent,experiments
R15524 T18076 T18073 pobj experiments,of
R15525 T18077 T18071 punct .,are
R15526 T18078 T18079 det All,data
R15527 T18079 T18085 nsubjpass data,analysed
R15528 T18080 T18079 prep except,data
R15529 T18081 T18082 punct (,E
R15530 T18082 T18080 pobj E,except
R15531 T18083 T18079 punct ),data
R15532 T18084 T18085 auxpass were,analysed
R15533 T18085 T18085 ROOT analysed,analysed
R15534 T18086 T18085 agent by,analysed
R15535 T18087 T18086 pobj ANOVA,by
R15536 T18088 T18085 prep followed,analysed
R15537 T18089 T18088 agent by,followed
R15538 T18090 T18089 pobj Newman-Keuls,by
R15539 T18091 T18088 advmod post-test,followed
R15540 T18092 T18085 punct .,analysed
R15666 T18334 T18335 compound Fluticasone,propionate
R15667 T18335 T18336 nsubj propionate,competes
R15668 T18336 T18336 ROOT competes,competes
R15669 T18337 T18336 prep with,competes
R15670 T18338 T18337 pobj phospho-GATA-3,with
R15671 T18339 T18338 prep for,phospho-GATA-3
R15672 T18340 T18339 pobj importin-α,for
R15673 T18341 T18336 punct .,competes
R15674 T18342 T18346 punct (,representation
R15675 T18343 T18346 det A,representation
R15676 T18344 T18346 punct ),representation
R15677 T18345 T18346 amod schematic,representation
R15678 T18346 T18346 ROOT representation,representation
R15679 T18347 T18346 prep of,representation
R15680 T18348 T18353 det the,assay
R15681 T18349 T18353 nmod in,assay
R15682 T18350 T18353 amod vitro,assay
R15683 T18351 T18352 amod binding,competition
R15684 T18352 T18353 compound competition,assay
R15685 T18353 T18347 pobj assay,of
R15686 T18354 T18346 punct .,representation
R15687 T18355 T18358 punct (,GR
R15688 T18356 T18358 nmod B,GR
R15689 T18357 T18358 punct ),GR
R15690 T18358 T18359 nsubj GR,isolated
R15691 T18359 T18359 ROOT isolated,isolated
R15692 T18360 T18359 prep from,isolated
R15693 T18361 T18360 pobj FP,from
R15694 T18362 T18361 punct (,FP
R15695 T18363 T18364 nummod 10,−
R15696 T18364 T18361 appos −,FP
R15697 T18365 T18366 nummod 8,M
R15698 T18366 T18364 appos M,−
R15699 T18367 T18364 punct ),−
R15700 T18368 T18369 amod stimulated,cells
R15701 T18369 T18370 nsubj cells,enhances
R15702 T18370 T18370 ROOT enhances,enhances
R15703 T18371 T18370 dobj GR,enhances
R15704 T18372 T18373 nsubj importin-α,binding
R15705 T18373 T18370 oprd binding,enhances
R15706 T18374 T18373 prep in,binding
R15707 T18375 T18376 det the,presence
R15708 T18376 T18374 pobj presence,in
R15709 T18377 T18378 punct (,•
R15710 T18378 T18376 appos •,presence
R15711 T18379 T18378 punct ),•
R15712 T18380 T18378 cc and,•
R15713 T18381 T18378 conj absence,•
R15714 T18382 T18383 punct (,▪
R15715 T18383 T18381 appos ▪,absence
R15716 T18384 T18376 punct ),presence
R15717 T18385 T18376 prep of,presence
R15718 T18386 T18387 amod activated,GATA-3
R15719 T18387 T18385 pobj GATA-3,of
R15720 T18388 T18370 punct .,enhances
R15721 T18389 T18393 punct *,compared
R15722 T18390 T18391 compound p,<
R15723 T18391 T18392 compound <,0.05
R15724 T18392 T18393 nsubj 0.05,compared
R15725 T18393 T18393 ROOT compared,compared
R15726 T18394 T18393 prep to,compared
R15727 T18395 T18397 det no,GR
R15728 T18396 T18397 amod activated,GR
R15729 T18397 T18394 pobj GR,to
R15730 T18398 T18393 punct .,compared
R15731 T18399 T18400 punct (,C
R15732 T18400 T18400 ROOT C,C
R15733 T18401 T18400 punct ),C
R15734 T18402 T18403 nsubj GATA-3,isolated
R15735 T18403 T18412 csubj isolated,attenuate
R15736 T18404 T18403 prep from,isolated
R15737 T18405 T18406 compound anti-CD3,/
R15738 T18406 T18408 npadvmod /,stimulated
R15739 T18407 T18406 nummod CD28,/
R15740 T18408 T18409 amod stimulated,cells
R15741 T18409 T18404 pobj cells,from
R15742 T18410 T18412 aux does,attenuate
R15743 T18411 T18412 neg not,attenuate
R15744 T18412 T18412 ROOT attenuate,attenuate
R15745 T18413 T18412 dobj GR,attenuate
R15746 T18414 T18415 amod importin-α,association
R15747 T18415 T18413 appos association,GR
R15748 T18416 T18412 punct .,attenuate
R15749 T18417 T18417 ROOT *,*
R15750 T18418 T18419 compound p,<
R15751 T18419 T18420 compound <,0.05
R15752 T18420 T18421 nsubj 0.05,compared
R15753 T18421 T18421 ROOT compared,compared
R15754 T18422 T18423 aux to,control
R15755 T18423 T18421 xcomp control,compared
R15756 T18424 T18421 punct .,compared
R15757 T18425 T18430 punct (,blocks
R15758 T18426 T18429 compound D,GR
R15759 T18427 T18428 punct ),Activated
R15760 T18428 T18429 compound Activated,GR
R15761 T18429 T18430 nsubj GR,blocks
R15762 T18430 T18430 ROOT blocks,blocks
R15763 T18431 T18432 det the,ability
R15764 T18432 T18430 dobj ability,blocks
R15765 T18433 T18432 prep of,ability
R15766 T18434 T18435 amod purified,phospho-GATA-3
R15767 T18435 T18436 amod phospho-GATA-3,isolated
R15768 T18436 T18433 pobj isolated,of
R15769 T18437 T18436 prep from,isolated
R15770 T18438 T18439 compound anti-CD3,/
R15771 T18439 T18440 compound /,CD28
R15772 T18440 T18437 pobj CD28,from
R15773 T18441 T18442 amod stimulated,cells
R15774 T18442 T18430 dobj cells,blocks
R15775 T18443 T18442 acl interacting,cells
R15776 T18444 T18443 prep with,interacting
R15777 T18445 T18446 amod immobilised,importin-α
R15779 T18447 T18443 prep in,interacting
R15780 T18448 T18452 det an,assay
R15781 T18449 T18452 nmod in,assay
R15782 T18450 T18452 amod vitro,assay
R15783 T18451 T18452 amod binding,assay
R15784 T18452 T18447 pobj assay,in
R15785 T18453 T18430 punct .,blocks
R15786 T18454 T18461 punct *,isolated
R15787 T18455 T18456 compound p,<
R15788 T18456 T18457 compound <,0.05
R15789 T18457 T18461 nsubjpass 0.05,isolated
R15790 T18458 T18461 prep compared,isolated
R15791 T18459 T18461 aux to,isolated
R15792 T18460 T18461 nsubj GATA-3,isolated
R15793 T18461 T18461 ROOT isolated,isolated
R15794 T18462 T18461 prep from,isolated
R15795 T18463 T18464 amod unstimulated,cells
R15796 T18464 T18462 pobj cells,from
R15797 T18465 T18461 punct .,isolated
R15798 T18466 T18468 amod # p,0.05
R15799 T18467 T18468 compound <,0.05
R15800 T18468 T18469 nsubj 0.05,compared
R15801 T18469 T18469 ROOT compared,compared
R15802 T18470 T18471 aux to,stimulated
R15803 T18471 T18469 xcomp stimulated,compared
R15804 T18472 T18473 advmod GATA-3-importin,binding
R15805 T18473 T18471 oprd binding,stimulated
R15806 T18474 T18469 punct .,compared
R15807 T18475 T18476 punct (,E
R15808 T18476 T18476 ROOT E,E
R15809 T18477 T18476 punct ),E
R15810 T18478 T18479 det The,effect
R15811 T18479 T18497 nsubj effect,was
R15812 T18480 T18479 prep of,effect
R15813 T18481 T18483 amod activated,•
R15814 T18482 T18483 punct (,•
R15815 T18483 T18480 pobj •,of
R15816 T18484 T18483 punct ),•
R15817 T18485 T18483 cc versus,•
R15818 T18486 T18483 conj unstimulated,•
R15819 T18487 T18488 punct (,○
R15820 T18488 T18486 appos ○,unstimulated
R15821 T18489 T18483 punct ),•
R15822 T18490 T18479 conj GR,effect
R15823 T18491 T18490 prep on,GR
R15824 T18492 T18491 pobj attenuation,on
R15825 T18493 T18492 prep of,attenuation
R15826 T18494 T18493 pobj GATA-3,of
R15827 T18495 T18496 amod importin-α,association
R15828 T18496 T18497 nsubj association,was
R15829 T18497 T18497 ROOT was,was
R15830 T18498 T18497 acomp concentration-dependent,was
R16175 T18945 T18944 acl showing,analysis
R16176 T18946 T18959 mark that,affect
R16177 T18947 T18959 det the,affect
R16178 T18948 T18950 amod nuclear,inhibitor
R16179 T18949 T18950 compound export,inhibitor
R16180 T18950 T18959 nsubj inhibitor,affect
R16181 T18951 T18952 compound leptomycin,B
R16182 T18952 T18950 appos B,inhibitor
R16183 T18953 T18954 punct (,2
R16184 T18954 T18955 nummod 2,nM
R16185 T18955 T18952 appos nM,B
R16186 T18956 T18952 punct ),B
R16187 T18957 T18959 aux does,affect
R16188 T18958 T18959 neg not,affect
R16189 T18959 T18945 ccomp affect,showing
R16190 T18960 T18961 det the,ability
R16191 T18961 T18959 dobj ability,affect
R16192 T18962 T18961 prep of,ability
R16193 T18963 T18962 pobj FP,of
R16194 T18964 T18963 punct (,FP
R16195 T18965 T18966 nummod 10,−
R16196 T18966 T18963 appos −,FP
R16197 T18967 T18968 nummod 8,M
R16198 T18968 T18966 appos M,−
R16199 T18969 T18966 punct ),−
R16200 T18970 T18971 aux to,prevent
R16201 T18971 T18961 acl prevent,ability
R16202 T18972 T18973 compound anti-CD3,/
R16203 T18973 T18971 dobj /,prevent
R16204 T18974 T18973 nummod CD28,/
R16206 T18976 T18978 amod GATA-3,localization
R16207 T18977 T18978 amod nuclear,localization
R16208 T18978 T18975 dobj localization,stimulated
R16209 T18979 T18978 acl measured,localization
R16210 T18980 T18979 prep at,measured
R16211 T18981 T18982 nummod 60,min
R16212 T18982 T18980 pobj min,at
R16213 T18983 T18975 punct .,stimulated
R16214 T18984 T18986 compound ***,<
R16215 T18985 T18986 compound p,<
R16216 T18986 T18988 nsubj <,compared
R16217 T18987 T18986 nummod 0.001,<
R16218 T18988 T18997 prep compared,compared
R16219 T18989 T18988 prep to,compared
R16220 T18990 T18991 amod unstimulated,cells
R16221 T18991 T18989 pobj cells,to
R16222 T18992 T18997 punct ",",compared
R16223 T18993 T18995 nmod ###,<
R16224 T18994 T18995 nmod p,<
R16225 T18995 T18996 nmod <,0.001
R16226 T18996 T18997 nsubj 0.001,compared
R16227 T18997 T18997 ROOT compared,compared
R16228 T18998 T18997 prep to,compared
R16252 T19022 T19011 ccomp affect,showing
R16253 T19023 T19025 amod whole-cell,degradation
R16254 T19024 T19025 amod GATA-3,degradation
R16255 T19025 T19022 dobj degradation,affect
R16256 T19026 T19025 prep over,degradation
R16257 T19027 T19028 nummod 17,h.
R16258 T19028 T19026 pobj h.,over
R16259 T19029 T19030 punct (,C
R16260 T19030 T19028 appos C,h.
R16261 T19031 T19030 punct ),C
R16262 T19032 T19033 amod GFP-tagged,GATA-3
R16263 T19033 T19034 nsubj GATA-3,is
R16264 T19034 T19034 ROOT is,is
R16265 T19035 T19034 acomp overexpressed,is
R16266 T19036 T19035 cc and,overexpressed
R16267 T19037 T19035 conj cells,overexpressed
R16268 T19038 T19037 acl stimulated,cells
R16269 T19039 T19041 punct (,j
R16270 T19040 T19041 nmod b,j
R16271 T19041 T19038 dobj j,stimulated
R16272 T19042 T19041 punct ),j
R16273 T19043 T19038 cc or,stimulated
R16274 T19044 T19045 neg not,(
R16275 T19045 T19046 punct (,a
R16276 T19046 T19037 appos a,cells
R16277 T19047 T19046 punct ),a
R16278 T19048 T19046 prep with,a
R16279 T19049 T19050 amod anti-CD3,/
R16280 T19050 T19051 compound /,CD28
R16281 T19051 T19048 pobj CD28,with
R16282 T19052 T19034 punct .,is
R16283 T19053 T19054 det The,effect
R16284 T19054 T19079 nsubjpass effect,shown
R16285 T19055 T19054 prep of,effect
R16286 T19056 T19055 pcomp treating,of
R16287 T19057 T19056 dobj cells,treating
R16288 T19058 T19056 prep with,treating
R16289 T19059 T19058 pobj FP,with
R16290 T19060 T19062 punct (,−
R16291 T19061 T19062 nummod 10,−
R16292 T19062 T19079 npadvmod −,shown
R16293 T19063 T19062 nummod 8,−
R16294 T19064 T19079 npadvmod M,shown
R16295 T19065 T19079 punct ",",shown
R16296 T19066 T19079 nsubjpass f,shown
R16297 T19067 T19066 appos j,f
R16298 T19068 T19066 punct ),f
R16299 T19069 T19066 prep after,f
R16300 T19070 T19072 nummod 30,stimulation
R16301 T19071 T19072 compound min,stimulation
R16302 T19072 T19069 pobj stimulation,after
R16303 T19073 T19072 prep with,stimulation
R16304 T19074 T19075 amod anti-CD3,/
R16305 T19075 T19076 compound /,CD28
R16306 T19076 T19073 pobj CD28,with
R16307 T19077 T19079 auxpass is,shown
R16308 T19078 T19079 advmod also,shown
R16309 T19079 T19079 ROOT shown,shown
R16310 T19080 T19079 punct .,shown
R16311 T19081 T19084 punct (,FP
R16312 T19082 T19084 nmod D,FP
R16313 T19083 T19084 punct ),FP
R16314 T19084 T19093 nsubj FP,prevent
R16315 T19085 T19087 punct (,−
R16316 T19086 T19087 nummod 10,−
R16317 T19087 T19093 nsubj −,prevent
R16318 T19088 T19087 nummod 8,−
R16319 T19089 T19087 appos M,−
R16320 T19090 T19087 punct ),−
R16321 T19091 T19093 aux does,prevent
R16322 T19092 T19093 neg not,prevent
R16323 T19093 T19097 ccomp prevent,stimulated
R16324 T19094 T19095 compound anti-CD3,/
R16325 T19095 T19093 dobj /,prevent
R16326 T19096 T19095 nummod CD28,/
R16327 T19097 T19097 ROOT stimulated,stimulated
R16328 T19098 T19100 nummod p65,translocation
R16329 T19099 T19100 amod nuclear,translocation
R16330 T19100 T19097 dobj translocation,stimulated
R16331 T19101 T19097 prep at,stimulated
R16332 T19102 T19103 nummod 60,min
R16333 T19103 T19101 pobj min,at
R16334 T19104 T19103 prep after,min
R16335 T19105 T19104 pobj stimulation,after
R16336 T19106 T19097 punct .,stimulated
R16337 T19107 T19111 dep **,compared
R16338 T19108 T19111 nsubj p,compared
R16339 T19109 T19110 nmod <,0.01
R16340 T19110 T19108 npadvmod 0.01,p
R16341 T19111 T19111 ROOT compared,compared
R16342 T19112 T19111 prep to,compared
R16343 T19113 T19114 amod unstimulated,cells
R16344 T19114 T19112 pobj cells,to
R16345 T19115 T19111 punct .,compared
R16346 T19116 T19117 det All,results
R16347 T19117 T19118 nsubj results,are
R16348 T19118 T19118 ROOT are,are
R16349 T19119 T19118 attr representative,are
R16350 T19120 T19119 prep of,representative
R16351 T19121 T19122 advmod at,least
R16352 T19122 T19123 advmod least,four
R16353 T19123 T19125 nummod four,experiments
R16354 T19124 T19125 amod independent,experiments
R16355 T19125 T19120 pobj experiments,of
R16356 T19126 T19118 cc and,are
R16357 T19127 T19128 auxpass are,shown
R16358 T19128 T19118 conj shown,are
R16359 T19129 T19128 prep as,shown
R16360 T19130 T19132 amod mean,SEM
R16361 T19131 T19132 compound ±,SEM
R16362 T19132 T19129 pobj SEM,as
R16363 T19133 T19118 punct .,are
R16364 T19134 T19136 nsubjpass Results,analysed
R16365 T19135 T19136 auxpass were,analysed
R16366 T19136 T19136 ROOT analysed,analysed
R16367 T19137 T19136 agent by,analysed
R16368 T19138 T19137 pobj ANOVA,by
R16369 T19139 T19136 acl followed,analysed
R16370 T19140 T19139 agent by,followed
R16371 T19141 T19142 compound Newman-Keuls,test
R16372 T19142 T19140 pobj test,by
R16373 T19143 T19136 punct .,analysed
R16592 T19430 T19431 compound Fluticasone,propionate
R16593 T19431 T19432 nsubj propionate,impairs
R16594 T19432 T19432 ROOT impairs,impairs
R16595 T19433 T19434 amod GATA-3,interaction
R16596 T19434 T19432 dobj interaction,impairs
R16597 T19435 T19434 prep with,interaction
R16598 T19436 T19440 amod importin-α,localization
R16599 T19437 T19436 cc and,importin-α
R16600 T19438 T19436 conj GATA-3,importin-α
R16601 T19439 T19440 amod nuclear,localization
R16602 T19440 T19435 pobj localization,with
R16603 T19441 T19440 prep in,localization
R16604 T19442 T19441 pobj vivo,in
R16605 T19443 T19442 cc and,vivo
R16606 T19444 T19445 dep ex,vivo
R16607 T19445 T19442 conj vivo,vivo
R16608 T19446 T19432 punct .,impairs
R16609 T19447 T19448 punct (,A
R16610 T19448 T19448 ROOT A,A
R16611 T19449 T19448 cc and,A
R16612 T19450 T19453 nmod B,analysis
R16613 T19451 T19450 punct ),B
R16614 T19452 T19453 compound Co-immunoprecipitation,analysis
R16615 T19453 T19465 nsubj analysis,demonstrated
R16616 T19454 T19453 prep of,analysis
R16617 T19455 T19454 pobj PBMCs,of
R16618 T19456 T19455 prep from,PBMCs
R16619 T19457 T19459 amod steroid-naïve,patients
R16620 T19458 T19459 compound asthma,patients
R16621 T19459 T19456 pobj patients,from
R16622 T19460 T19459 acl treated,patients
R16623 T19461 T19460 prep with,treated
R16624 T19462 T19461 pobj FP,with
R16625 T19463 T19460 prep in,treated
R16626 T19464 T19463 pobj vitro,in
R16627 T19465 T19448 conj demonstrated,A
R16628 T19466 T19467 amod impaired,interaction
R16629 T19467 T19465 dobj interaction,demonstrated
R16630 T19468 T19467 prep between,interaction
R16631 T19469 T19468 pobj GATA-3,between
R16632 T19470 T19469 cc and,GATA-3
R16633 T19471 T19469 conj importin-α,GATA-3
R16634 T19472 T19465 conj measured,demonstrated
R16635 T19473 T19472 prep at,measured
R16636 T19474 T19475 nummod 60,min
R16637 T19475 T19473 pobj min,at
R16638 T19476 T19465 punct .,demonstrated
R16639 T19477 T19478 det Each,bar
R16640 T19478 T19479 nsubj bar,represents
R16641 T19479 T19479 ROOT represents,represents
R16642 T19480 T19483 det the,SEM
R16643 T19481 T19483 amod mean,SEM
R16644 T19482 T19483 compound ±,SEM
R16645 T19483 T19479 dobj SEM,represents
R16646 T19484 T19483 prep of,SEM
R16647 T19485 T19486 advmod at,least
R16648 T19486 T19487 advmod least,three
R16649 T19487 T19489 nummod three,experiments
R16650 T19488 T19489 amod independent,experiments
R16651 T19489 T19484 pobj experiments,of
R16652 T19490 T19483 punct ;,SEM
R16653 T19491 T19493 nmod ***,<
R16654 T19492 T19493 nmod p,<
R16655 T19493 T19494 nmod <,0.001
R16656 T19494 T19483 appos 0.001,SEM
R16657 T19495 T19494 prep compared,0.001
R16658 T19496 T19495 prep with,compared
R16659 T19497 T19496 pobj control,with
R16660 T19498 T19499 mark as,determined
R16661 T19499 T19494 advcl determined,0.001
R16662 T19500 T19499 agent by,determined
R16663 T19501 T19502 compound ANOVA/Newman-Keuls,analysis
R16664 T19502 T19500 pobj analysis,by
R16665 T19503 T19479 punct .,represents
R16666 T19504 T19505 punct (,C
R16667 T19505 T19505 ROOT C,C
R16668 T19506 T19505 cc and,C
R16669 T19507 T19505 conj D,C
R16670 T19508 T19505 punct ),C
R16671 T19509 T19510 compound Co-immunoprecipitation,analyses
R16672 T19510 T19530 nsubj analyses,demonstrated
R16673 T19511 T19510 prep of,analyses
R16674 T19512 T19511 pobj PBMCs,of
R16675 T19513 T19512 prep from,PBMCs
R16676 T19514 T19516 amod steroid-naïve,patients
R16677 T19515 T19516 compound asthma,patients
R16678 T19516 T19513 pobj patients,from
R16679 T19517 T19516 acl treated,patients
R16680 T19518 T19517 prep with,treated
R16681 T19519 T19520 amod inhaled,FP
R16682 T19520 T19518 pobj FP,with
R16683 T19521 T19520 punct (,FP
R16684 T19522 T19523 nummod 500,µg
R16685 T19523 T19520 appos µg,FP
R16686 T19524 T19517 prep via,treated
R16687 T19525 T19526 det a,spacer
R16688 T19526 T19524 pobj spacer,via
R16689 T19527 T19517 punct ),treated
R16690 T19528 T19517 prep in,treated
R16691 T19529 T19528 pobj vivo,in
R16692 T19530 T19530 ROOT demonstrated,demonstrated
R16693 T19531 T19532 amod decreased,association
R16694 T19532 T19530 dobj association,demonstrated
R16695 T19533 T19532 prep between,association
R16696 T19534 T19533 pobj GATA-3,between
R16697 T19535 T19534 cc and,GATA-3
R16698 T19536 T19534 conj importin-α,GATA-3
R16699 T19537 T19530 punct .,demonstrated
R16700 T19538 T19540 det The,values
R16701 T19539 T19540 amod individual,values
R16702 T19540 T19545 nsubjpass values,presented
R16703 T19541 T19540 prep for,values
R16704 T19542 T19543 det each,treatment
R16705 T19543 T19541 pobj treatment,for
R16706 T19544 T19545 auxpass are,presented
R16707 T19545 T19545 ROOT presented,presented
R16708 T19546 T19545 advmod graphically,presented
R16709 T19547 T19545 punct .,presented
R16710 T19548 T19554 punct (,showing
R16711 T19549 T19553 nmod E,blot
R16712 T19550 T19549 punct ),E
R16713 T19551 T19553 compound Representative,blot
R16714 T19552 T19553 compound Western,blot
R16715 T19553 T19554 nsubj blot,showing
R16716 T19554 T19554 ROOT showing,showing
R16717 T19555 T19559 mark that,unaffected
R16718 T19556 T19557 amod importin-α,expression
R16719 T19557 T19559 nsubjpass expression,unaffected
R16720 T19558 T19559 auxpass was,unaffected
R16721 T19559 T19554 ccomp unaffected,showing
R16722 T19560 T19559 prep by,unaffected
R16723 T19561 T19560 pobj inhalation,by
R16724 T19562 T19561 prep of,inhalation
R16725 T19563 T19562 pobj FP,of
R16726 T19564 T19554 punct .,showing
R16727 T19565 T19566 nsubj Blot,is
R16728 T19566 T19566 ROOT is,is
R16729 T19567 T19566 attr representative,is
R16730 T19568 T19567 prep of,representative
R16731 T19569 T19568 pobj gels,of
R16732 T19570 T19567 prep from,representative
R16733 T19571 T19572 nummod three,participants
R16734 T19572 T19570 pobj participants,from
R16735 T19573 T19566 punct .,is
R17076 T19983 T19985 amod Inhaled,propionate
R17077 T19984 T19985 compound fluticasone,propionate
R17078 T19985 T19986 nsubj propionate,impairs
R17079 T19986 T19986 ROOT impairs,impairs
R17080 T19987 T19989 amod GATA-3,localization
R17081 T19988 T19989 amod nuclear,localization
R17082 T19989 T19986 dobj localization,impairs
R17083 T19990 T19989 prep in,localization
R17084 T19991 T19990 pobj PBMCs,in
R17085 T19992 T19986 punct .,impairs
R17086 T19993 T19993 ROOT (,(
R17087 T19994 T19993 dep A,(
R17088 T19995 T19994 punct ),A
R17089 T19996 T19997 compound Representative,immunocytochemistry
R17090 T19997 T19997 ROOT immunocytochemistry,immunocytochemistry
R17091 T19998 T19997 prep of,immunocytochemistry
R17092 T19999 T19998 pcomp showing,of
R17093 T20000 T20001 det the,effect
R17094 T20001 T19999 dobj effect,showing
R17095 T20002 T20001 prep of,effect
R17096 T20003 T20004 amod inhaled,FP
R17097 T20004 T20002 pobj FP,of
R17098 T20005 T20007 punct (,µg
R17099 T20006 T20007 nummod 500,µg
R17100 T20007 T20004 appos µg,FP
R17122 T20029 T20030 nummod 2,h
R17123 T20030 T20031 amod h,following
R17124 T20031 T20021 prep following,immunoreactivity
R17125 T20032 T20034 amod inhaled,treatment
R17126 T20033 T20034 compound FP,treatment
R17127 T20034 T20031 dobj treatment,following
R17128 T20035 T20034 punct (,treatment
R17129 T20036 T20039 nummod 100,µg
R17130 T20037 T20036 cc or,100
R17131 T20038 T20036 conj 500,100
R17132 T20039 T20034 appos µg,treatment
R17133 T20040 T20039 prep via,µg
R17134 T20041 T20040 pobj spacer,via
R17135 T20042 T20034 punct ),treatment
R17136 T20043 T20021 punct .,immunoreactivity
R17137 T20044 T20048 det The,ranges
R17138 T20045 T20048 amod median,ranges
R17139 T20046 T20045 cc and,median
R17140 T20047 T20045 conj interquartile,median
R17141 T20048 T20053 nsubjpass ranges,presented
R17142 T20049 T20048 prep for,ranges
R17143 T20050 T20051 det each,treatment
R17144 T20051 T20049 pobj treatment,for
R17145 T20052 T20053 auxpass are,presented
R17146 T20053 T20053 ROOT presented,presented
R17147 T20054 T20053 prep as,presented
R17148 T20055 T20057 det a,plot
R17149 T20056 T20057 compound box-and-whiskers,plot
R17150 T20057 T20054 pobj plot,as
R17151 T20058 T20061 punct (,7
R17152 T20059 T20061 advmod n,7
R17153 T20060 T20061 punct =,7
R17154 T20061 T20057 appos 7,plot
R17155 T20062 T20061 punct ),7
R17156 T20063 T20053 punct ;,presented
R17200 T20107 T20110 nsubj analyses,demonstrated
R17201 T20108 T20107 prep of,analyses
R17202 T20109 T20108 pobj PBMCs,of
R17203 T20110 T20110 ROOT demonstrated,demonstrated
R17204 T20111 T20113 det a,decrease
R17205 T20112 T20113 amod dose-dependent,decrease
R17206 T20113 T20110 dobj decrease,demonstrated
R17207 T20114 T20113 prep in,decrease
R17208 T20115 T20116 amod nuclear,expression
R17209 T20116 T20114 pobj expression,in
R17210 T20117 T20116 prep of,expression
R17211 T20118 T20117 pobj GATA-3,of
R17212 T20119 T20110 punct ",",demonstrated
R17213 T20120 T20110 cc and,demonstrated
R17214 T20121 T20110 conj increased,demonstrated
R17215 T20122 T20124 amod cytoplasmic,expression
R17216 T20123 T20124 amod GATA-3,expression
R17217 T20124 T20121 dobj expression,increased
R17218 T20125 T20126 nummod 2,h
R17219 T20126 T20124 appos h,expression
R17220 T20127 T20126 prep after,h
R17221 T20128 T20127 pobj inhalation,after
R17222 T20129 T20128 prep of,inhalation
R17223 T20130 T20129 pobj FP,of
R17224 T20131 T20110 punct .,demonstrated
R17225 T20132 T20133 compound Histone,H1
R17226 T20133 T20137 nsubj H1,confirmed
R17227 T20134 T20133 cc and,H1
R17228 T20135 T20133 conj MEK-1,H1
R17229 T20136 T20137 nsubj immunoblotting,confirmed
R17230 T20137 T20137 ROOT confirmed,confirmed
R17231 T20138 T20141 amod equivalent,loading
R17232 T20139 T20140 amod total,protein
R17233 T20140 T20141 compound protein,loading
R17234 T20141 T20137 dobj loading,confirmed
R17235 T20142 T20141 prep for,loading
R17236 T20143 T20147 det the,fractions
R17279 T20186 T20186 ROOT compared,compared
R17280 T20187 T20188 aux to,control
R17281 T20188 T20186 xcomp control,compared
R17282 T20189 T20164 punct .,shown
R17283 T20190 T20198 punct (,demonstrated
R17284 T20191 T20195 nmod E,analyses
R17285 T20192 T20191 punct ),E
R17286 T20193 T20195 amod Western,analyses
R17287 T20194 T20195 compound blot,analyses
R17288 T20195 T20198 nsubj analyses,demonstrated
R17289 T20196 T20195 prep of,analyses
R17290 T20197 T20196 pobj PBMCs,of
R17291 T20198 T20198 ROOT demonstrated,demonstrated
R17292 T20199 T20201 det a,decrease
R17293 T20200 T20201 amod time-dependent,decrease
R17294 T20201 T20198 dobj decrease,demonstrated
R17295 T20202 T20201 prep in,decrease
R17296 T20203 T20204 amod dual,phosphorylation
R17297 T20204 T20202 pobj phosphorylation,in
R17298 T20205 T20206 punct (,threonine-180
R17299 T20206 T20204 appos threonine-180,phosphorylation
R17300 T20207 T20206 cc and,threonine-180
R17301 T20208 T20206 conj tyrosine-182,threonine-180
R17302 T20209 T20206 punct ),threonine-180
R17303 T20210 T20206 prep of,threonine-180
R17304 T20211 T20212 nummod p38,MAPK
R17305 T20212 T20210 pobj MAPK,of
R17306 T20213 T20198 prep after,demonstrated
R17307 T20214 T20213 pobj inhalation,after
R17308 T20215 T20214 prep of,inhalation
R17309 T20216 T20215 pobj FP,of
R17310 T20217 T20219 punct (,µg
R17311 T20218 T20219 nummod 500,µg
R17312 T20219 T20216 appos µg,FP
R17313 T20220 T20219 punct ),µg
R17314 T20221 T20198 punct .,demonstrated
R17321 T20228 T20223 punct ),results
R17322 T20229 T20229 ROOT are,are
R17323 T20230 T20229 attr representative,are
R17324 T20231 T20230 prep of,representative
R17325 T20232 T20231 pobj samples,of
R17326 T20233 T20232 prep from,samples
R17327 T20234 T20235 nummod two,participants
R17328 T20235 T20233 pobj participants,from
R17329 T20236 T20229 punct .,are
R7330 T8485 T8482 ccomp affect,investigated
R7331 T8486 T8487 compound anti-CD3,/
R7332 T8487 T8485 dobj /,affect
R7333 T8488 T8487 nummod CD28,/
R7334 T8489 T8482 dep stimulated,investigated
R7335 T8490 T8491 amod nuclear,import
R7336 T8491 T8489 dobj import,stimulated
R7337 T8492 T8491 prep of,import
R7338 T8493 T8492 pobj GATA-3,of
R7339 T8494 T8482 punct .,investigated
R7340 T8495 T8502 nsubj Stimulation,resulted
R7341 T8496 T8495 prep of,Stimulation
R7342 T8497 T8496 pobj cells,of
R7343 T8498 T8497 prep with,cells
R7344 T8499 T8500 compound anti-CD3,/
R7345 T8500 T8498 pobj /,with
R7346 T8501 T8500 nummod CD28,/
R7482 T8637 T8636 prep of,loss
R7483 T8638 T8639 amod GATA-3,binding
R7484 T8639 T8636 amod binding,loss
R7485 T8640 T8639 prep to,binding
R7486 T8641 T8644 det the,promoter
R7488 T8643 T8644 compound IL-5,promoter
R7489 T8644 T8640 pobj promoter,to
R7490 T8645 T8646 punct (,Figure
R7491 T8646 T8644 appos Figure,promoter
R7492 T8647 T8646 nummod 1E,Figure
R7493 T8648 T8646 punct ),Figure
R7494 T8649 T8587 punct .,was
R7848 T9109 T9110 compound Ligand-Activated,GR
R8972 T10422 T10417 acl utilizing,assay
R8973 T10423 T10425 amod purified,GATA-3
R8974 T10424 T10425 amod activated,GATA-3
R8975 T10425 T10422 dobj GATA-3,utilizing
R8976 T10426 T10425 punct ",",GATA-3
R8977 T10427 T10425 conj importin-α,GATA-3
R8978 T10428 T10412 punct ",",Using
R8979 T10429 T10412 cc and,Using
R8980 T10430 T10434 advcl activated,demonstrated
R8981 T10431 T10430 dobj GR,activated
R8982 T10432 T10434 punct ",",demonstrated
R8983 T10433 T10434 nsubj we,demonstrated
R8984 T10434 T10434 ROOT demonstrated,demonstrated
R8985 T10435 T10436 mark that,activated
R8986 T10436 T10434 ccomp activated,demonstrated
R8987 T10437 T10439 nsubj GR,increased
R8988 T10438 T10439 advmod significantly,increased
R9208 T10658 T10660 nummod p65,translocation
R9209 T10659 T10660 amod nuclear,translocation
R9210 T10660 T10657 pobj translocation,on
R9211 T10661 T10654 conj measured,had
R9212 T10662 T10661 prep at,measured
R9213 T10663 T10664 nummod 60,min
R9214 T10664 T10662 pobj min,at
R9215 T10665 T10666 punct (,Figure
R9216 T10666 T10664 appos Figure,min
R9217 T10667 T10666 nummod 5D,Figure
R9218 T10668 T10666 punct ),Figure
R9219 T10669 T10642 punct .,was
R10235 T11922 T11924 det The,Effect
R10236 T11923 T11924 compound Inhibitory,Effect
R10237 T11924 T11945 nsubj Effect,demonstrated
R10238 T11925 T11924 prep of,Effect
R10239 T11926 T11925 pobj Corticosteroids,of
R10240 T11927 T11924 prep on,Effect
R10241 T11928 T11930 compound GATA-3,Localization
R10242 T11929 T11930 compound Nuclear,Localization
R10243 T11930 T11927 pobj Localization,on
R10244 T11931 T11930 prep in,Localization
R10245 T11932 T11933 compound Primary,T
R10246 T11933 T11934 compound T,Lymphocytes
R10247 T11934 T11936 compound Lymphocytes,Vivo
R10248 T11935 T11936 compound Ex,Vivo
R10249 T11936 T11931 pobj Vivo,in
R10250 T11937 T11924 cc and,Effect
R10251 T11938 T11945 prep In,demonstrated
R10252 T11939 T11940 compound Vivo,Treatment
R10253 T11940 T11938 pobj Treatment,In
R10254 T11941 T11940 prep with,Treatment
R10255 T11942 T11944 compound FP,vivo
R10335 T12022 T12023 nsubj FP,suppresses
R10336 T12023 T12016 ccomp suppresses,indicated
R10337 T12024 T12023 dobj IL-4,suppresses
R10338 T12025 T12024 cc and,IL-4
R10339 T12026 T12028 nummod -5,expression
R10340 T12027 T12028 compound gene,expression
R10341 T12028 T12024 conj expression,IL-4
R10342 T12029 T12028 cc and,expression
R10343 T12030 T12016 conj attenuated,indicated
R10344 T12031 T12032 det the,interaction
R10345 T12032 T12030 dobj interaction,attenuated
R10346 T12033 T12032 prep of,interaction
R10347 T12034 T12033 pobj GATA-3,of
R10348 T12035 T12032 prep with,interaction
R10349 T12036 T12035 pobj importin-α,with
R10450 T12137 T12140 nsubj this,reach
R10451 T12138 T12140 aux did,reach
R10452 T12139 T12140 neg not,reach
R10453 T12140 T12140 ROOT reach,reach
R10454 T12141 T12140 dobj significance,reach
R10455 T12142 T12140 advcl using,reach
R10456 T12143 T12146 poss Wilcoxon,analysis
R10457 T12144 T12143 case 's,Wilcoxon
R10458 T12145 T12146 amod post-test,analysis
R10459 T12146 T12142 dobj analysis,using
R10460 T12147 T12153 punct (,due
R10461 T12148 T12153 nsubj W,due
R10462 T12149 T12150 punct =,6.00
R10463 T12150 T12148 nummod 6.00,W
R10464 T12151 T12148 punct ),W
R10465 T12152 T12153 advmod probably,due
R10466 T12153 T12140 advcl due,reach
R10467 T12154 T12153 pcomp to,due
R10468 T12155 T12156 amod low,numbers
R10469 T12156 T12154 pobj numbers,to
R10470 T12157 T12156 prep of,numbers
R10471 T12158 T12157 pobj participants,of
R10472 T12159 T12140 punct .,reach
R10473 T12160 T12161 amod Similar,results
R10474 T12161 T12163 nsubjpass results,observed
R10505 T12192 T12197 nsubj interaction,result
R10506 T12193 T12192 prep of,interaction
R10507 T12194 T12193 pobj GATA-3,of
R10508 T12195 T12197 aux did,result
R10509 T12196 T12197 neg not,result
R10510 T12197 T12197 ROOT result,result
R10511 T12198 T12197 prep from,result
R10512 T12199 T12201 det the,recycling
R10513 T12200 T12201 amod defective,recycling
R10514 T12201 T12198 pobj recycling,from
R10515 T12202 T12201 prep of,recycling
R10516 T12203 T12202 pobj importin-α,of
R10517 T12204 T12197 punct ",",result
R10518 T12205 T12197 prep as,result
R10519 T12206 T12208 det a,decrease
R10520 T12207 T12208 amod significant,decrease
R10521 T12208 T12205 pobj decrease,as
R10522 T12209 T12208 prep in,decrease
R10523 T12210 T12211 det the,abundance
R10524 T12211 T12209 pobj abundance,in
R10525 T12212 T12211 prep of,abundance
R10526 T12213 T12212 pobj importin-α,of
R10527 T12214 T12208 prep in,decrease
R10528 T12215 T12217 det the,pool
R10529 T12216 T12217 amod cytoplasmic,pool
R10530 T12217 T12214 pobj pool,in
R10531 T12218 T12220 auxpass was,detected
R10532 T12219 T12220 neg not,detected
R10533 T12220 T12197 conj detected,result
R10534 T12221 T12222 punct (,Figure
R10535 T12222 T12220 advmod Figure,detected
R10536 T12223 T12222 nummod 6E,Figure
R10537 T12224 T12222 punct ),Figure
R10538 T12225 T12197 punct .,result
R10539 T12226 T12228 nsubj We,examined
R10540 T12227 T12228 advmod further,examined
R10541 T12228 T12228 ROOT examined,examined
R10542 T12229 T12233 mark whether,affect
R10543 T12230 T12231 amod inhaled,FP
R10544 T12231 T12233 nsubj FP,affect
R10545 T12232 T12233 aux could,affect
R10546 T12233 T12228 ccomp affect,examined
R10547 T12234 T12235 amod cellular,localization
R10548 T12235 T12233 dobj localization,affect
R10549 T12236 T12235 prep of,localization
R10550 T12237 T12236 pobj GATA-3,of
R10551 T12238 T12235 prep in,localization
R10552 T12239 T12242 amod peripheral,cells
R10553 T12240 T12242 compound blood,cells
R10584 T12271 T12276 amod GATA-3,cells
R10661 T12348 T12349 nummod 500,µg
R10662 T12349 T12346 appos µg,FP
R10663 T12350 T12346 punct ),FP
R10664 T12351 T12345 conj induced,inhaled
R10665 T12352 T12353 amod significant,loss
R10776 T12463 T12464 compound T,cells
R10777 T12464 T12461 pobj cells,in
R10778 T12465 T12457 prep in,inhibited
R10779 T12466 T12465 pobj vivo,in
R10780 T12467 T12457 prep at,inhibited
R10781 T12468 T12469 nummod 2,h
R10782 T12469 T12467 pobj h,at
R10783 T12470 T12469 prep in,h
R10784 T12471 T12470 pobj samples,in
R10785 T12472 T12471 prep from,samples
R10786 T12473 T12474 nummod two,patients
R10787 T12474 T12472 pobj patients,from
R10788 T12475 T12474 punct (,patients
R10789 T12476 T12474 appos Figure,patients
R10790 T12477 T12476 nummod 7E,Figure
R10791 T12478 T12474 punct ),patients
R10792 T12479 T12457 punct .,inhibited
R10793 T12480 T12485 advcl Taken,suggest
R10794 T12481 T12480 advmod together,Taken
R10795 T12482 T12485 punct ",",suggest
R10796 T12483 T12484 poss our,data
R10797 T12484 T12485 nsubj data,suggest
R10798 T12485 T12485 ROOT suggest,suggest
R10799 T12486 T12487 mark that,inhaled
R10800 T12487 T12485 ccomp inhaled,suggest
R10801 T12488 T12489 nsubj FP,reduces
R10802 T12489 T12487 pcomp reduces,inhaled
R10803 T12490 T12491 amod nuclear,localization
R10804 T12491 T12489 dobj localization,reduces
R10805 T12492 T12491 prep of,localization
R10806 T12493 T12492 pobj GATA-3,of
R10807 T12494 T12491 prep in,localization
R10808 T12495 T12494 pobj vivo,in
R10809 T12496 T12489 prep by,reduces
R10810 T12497 T12498 advmod acutely,inhibiting
R10811 T12498 T12496 pcomp inhibiting,by
R14195 T16509 T16508 prep as,presented
R14693 T17131 T17128 pobj 8,at
R14694 T17132 T17133 compound M,FP
R14695 T17133 T17123 dobj FP,demonstrates
R14696 T17134 T17123 punct ),demonstrates
R14697 T17135 T17123 cc and,demonstrates
R14698 T17136 T17123 conj concentration,demonstrates
R14699 T17137 T17136 punct -,concentration
R14700 T17138 T17141 punct (,min
R14701 T17139 T17141 prep at,min
R14702 T17140 T17141 nummod 60,min
R14703 T17141 T17136 appos min,concentration
R14704 T17142 T17141 prep after,min
R14705 T17143 T17142 pobj stimulation,after
R14706 T17144 T17141 punct ),min
R14707 T17145 T17146 amod dependent,induction
R14708 T17146 T17136 conj induction,concentration
R14709 T17147 T17146 prep of,induction
R14710 T17148 T17150 amod FP-activated,interaction
R14711 T17149 T17150 compound GR,interaction
R14712 T17150 T17147 pobj interaction,of
R14713 T17151 T17150 prep with,interaction
R14714 T17152 T17151 pobj importin-α,with
R14715 T17153 T17154 punct (,Imp-α
R14716 T17154 T17152 appos Imp-α,importin-α
R14717 T17155 T17154 punct ),Imp-α
R14746 T17184 T17185 advmod at,least
R14747 T17185 T17186 advmod least,three
R14748 T17186 T17188 nummod three,experiments
R14749 T17187 T17188 amod independent,experiments
R14750 T17188 T17183 pobj experiments,of
R14751 T17189 T17179 punct .,represents
R14752 T17190 T17192 nmod ***,<
R14753 T17191 T17192 nmod p,<
R14754 T17192 T17193 nmod <,0.001
R14755 T17193 T17194 nsubj 0.001,compared
R14756 T17194 T17194 ROOT compared,compared
R14757 T17195 T17196 aux to,control
R14758 T17196 T17194 xcomp control,compared
R14759 T17197 T17200 punct ",",<
R14760 T17198 T17200 dep ###,<
R14761 T17199 T17200 dep p,<
R14762 T17200 T17201 nmod <,0.001
R14763 T17201 T17194 dobj 0.001,compared
R14764 T17202 T17194 punct .,compared
R14765 T17203 T17209 punct (,demonstrated
R14766 T17204 T17208 nmod B,analysis
R14767 T17205 T17204 punct ),B
R14768 T17206 T17208 compound Western,analysis
R14769 T17207 T17208 compound blot,analysis
R14770 T17208 T17209 nsubj analysis,demonstrated
R14771 T17209 T17209 ROOT demonstrated,demonstrated
R14772 T17210 T17232 det a,induction
R14773 T17211 T17232 npadvmod time,induction
R14774 T17212 T17232 punct -,induction
R14775 T17213 T17232 punct (,induction
R14776 T17214 T17232 nmod at,induction
R14777 T17215 T17219 nummod 10,FP
R14778 T17216 T17217 quantmod −,8
R14779 T17217 T17219 nummod 8,FP
R14780 T17218 T17219 compound M,FP
R14781 T17219 T17214 pobj FP,at
R14782 T17220 T17214 punct ),at
R14783 T17221 T17214 cc and,at
R14784 T17222 T17214 conj concentration,at
R14785 T17223 T17222 punct -,concentration
R14786 T17224 T17222 punct (,concentration
R14787 T17225 T17222 prep at,concentration
R14788 T17226 T17227 nummod 60,min
R14789 T17227 T17225 pobj min,at
R14790 T17228 T17227 prep after,min
R14791 T17229 T17228 pobj stimulation,after
R14792 T17230 T17222 punct ),concentration
R14793 T17231 T17232 amod dependent,induction
R14794 T17232 T17209 dobj induction,demonstrated
R14795 T17233 T17232 prep of,induction
R14824 T17262 T17257 pobj experiments,of
R14825 T17263 T17253 punct .,represents
R14826 T17264 T17266 compound ***,<
R14827 T17265 T17266 compound p,<
R14828 T17266 T17268 nsubj <,compared
R14829 T17267 T17266 nummod 0.001,<
R14830 T17268 T17268 ROOT compared,compared
R14831 T17269 T17270 aux to,control
R14832 T17270 T17268 xcomp control,compared
R14833 T17271 T17268 punct .,compared
R14834 T17272 T17273 punct (,C
R14835 T17273 T17277 nmod C,analysis
R14836 T17274 T17273 punct ),C
R14837 T17275 T17277 amod Western,analysis
R14838 T17276 T17277 compound blot,analysis
R14839 T17277 T17289 nsubj analysis,demonstrated
R14840 T17278 T17277 prep of,analysis
R14841 T17279 T17280 amod HuT-78,cells
R14842 T17280 T17278 pobj cells,of
R14843 T17281 T17280 acl treated,cells
R14844 T17282 T17281 prep with,treated
R14845 T17283 T17282 pobj FP,with
R14846 T17284 T17283 cc and,FP
R14847 T17285 T17286 compound anti-CD3,/
R14848 T17286 T17283 conj /,FP
R15497 T18049 T18048 pobj means,as
R15498 T18050 T18051 compound ±,SEM
R15499 T18051 T18054 dep SEM,p
R15500 T18052 T18051 punct ",",SEM
R15501 T18053 T18051 punct *,SEM
R15502 T18054 T18036 dep p,are
R15503 T18055 T18056 nmod <,0.05
R15504 T18056 T18054 npadvmod 0.05,p
R15505 T18057 T18036 punct .,are
R15506 T18058 T18062 punct (,induces
R15507 T18059 T18061 nmod E,FP
R15508 T18060 T18061 punct ),FP
R15509 T18061 T18062 nsubj FP,induces
R15510 T18062 T18062 ROOT induces,induces
R15511 T18063 T18064 compound MKP-1,mRNA
R15512 T18064 T18062 dobj mRNA,induces
R15513 T18065 T18062 prep in,induces
R15514 T18066 T18068 det a,manner
R15515 T18067 T18068 amod time-dependent,manner
R15516 T18068 T18065 pobj manner,in
R15517 T18069 T18062 punct .,induces
R15518 T18070 T18071 nsubj Results,are
R15519 T18071 T18071 ROOT are,are
R15520 T18072 T18071 attr representative,are
R15778 T18446 T18444 pobj importin-α,with
R15831 T18499 T18497 punct .,was
R15832 T18500 T18503 punct *,0.05
R15833 T18501 T18502 compound p,<
R15834 T18502 T18503 compound <,0.05
R15835 T18503 T18503 ROOT 0.05,0.05
R15836 T18504 T18508 punct ",",0.01
R15837 T18505 T18508 amod **,0.01
R15838 T18506 T18508 compound p,0.01
R15839 T18507 T18508 compound <,0.01
R15840 T18508 T18503 appos 0.01,0.05
R15841 T18509 T18508 prep between,0.01
R15842 T18510 T18509 pobj groups,between
R15843 T18511 T18503 punct .,0.05
R15844 T18512 T18513 det All,results
R15845 T18513 T18515 nsubjpass results,expressed
R15846 T18514 T18515 auxpass are,expressed
R15847 T18515 T18515 ROOT expressed,expressed
R15848 T18516 T18515 prep as,expressed
R15849 T18517 T18519 amod mean,SEM
R15850 T18518 T18519 compound ±,SEM
R15851 T18519 T18516 pobj SEM,as
R15852 T18520 T18519 prep of,SEM
R15853 T18521 T18523 nummod three,experiments
R15854 T18522 T18523 amod independent,experiments
R15855 T18523 T18520 pobj experiments,of
R16205 T18975 T18975 ROOT stimulated,stimulated
R15856 T18524 T18523 cc and,experiments
R15857 T18525 T18515 advcl analysed,expressed
R15858 T18526 T18525 agent by,analysed
R15859 T18527 T18526 pobj ANOVA,by
R15860 T18528 T18525 acl followed,analysed
R15861 T18529 T18528 agent by,followed
R15862 T18530 T18529 pobj Newman-Keuls,by
R15863 T18531 T18515 conj post-test,expressed
R15864 T18532 T18515 punct .,expressed
R16160 T18930 T18931 compound Fluticasone,propionate
R16161 T18931 T18934 nsubj propionate,affect
R16162 T18932 T18934 aux does,affect
R16163 T18933 T18934 neg not,affect
R16164 T18934 T18934 ROOT affect,affect
R16165 T18935 T18937 amod GATA-3,export
R16166 T18936 T18937 amod nuclear,export
R16167 T18937 T18934 dobj export,affect
R16168 T18938 T18934 punct .,affect
R16169 T18939 T18940 punct (,A
R16170 T18940 T18944 nmod A,analysis
R16171 T18941 T18940 punct ),A
R16172 T18942 T18944 amod Western,analysis
R16173 T18943 T18944 compound blot,analysis
R16174 T18944 T18975 nsubj analysis,stimulated
R16229 T18999 T19002 dep anti-CD3,stimulated
R16230 T19000 T18999 dobj /,anti-CD3
R16231 T19001 T19000 nummod CD28,/
R16232 T19002 T18998 pcomp stimulated,to
R16233 T19003 T19002 dobj cells,stimulated
R16234 T19004 T19002 punct .,stimulated
R16235 T19005 T19010 punct (,analysis
R16236 T19006 T19010 nmod B,analysis
R16237 T19007 T19010 punct ),analysis
R16238 T19008 T19010 amod Western,analysis
R16239 T19009 T19010 compound blot,analysis
R16240 T19010 T19010 ROOT analysis,analysis
R16241 T19011 T19010 acl showing,analysis
R16242 T19012 T19022 mark that,affect
R16243 T19013 T19022 nsubj FP,affect
R16244 T19014 T19016 punct (,−
R16245 T19015 T19016 nummod 10,−
R16246 T19016 T19022 nsubj −,affect
R16247 T19017 T19016 nummod 8,−
R16248 T19018 T19016 appos M,−
R16249 T19019 T19016 punct ),−
R16250 T19020 T19022 aux does,affect
R16251 T19021 T19022 neg not,affect
R17101 T20008 T20004 punct ),FP
R17102 T20009 T20001 prep on,effect
R17103 T20010 T20014 nmod GR,localisation
R17104 T20011 T20010 cc and,GR
R17105 T20012 T20010 conj GATA-3,GR
R17106 T20013 T20014 amod nuclear,localisation
R17107 T20014 T20009 pobj localisation,on
R17108 T20015 T19997 punct .,immunocytochemistry
R17109 T20016 T20021 punct (,immunoreactivity
R17110 T20017 T20021 nmod B,immunoreactivity
R17111 T20018 T20017 punct ),B
R17112 T20019 T20020 compound Nuclear,GATA-3
R17113 T20020 T20021 compound GATA-3,immunoreactivity
R17114 T20021 T20021 ROOT immunoreactivity,immunoreactivity
R17115 T20022 T20021 prep in,immunoreactivity
R17116 T20023 T20022 pobj PBMCs,in
R17117 T20024 T20021 prep from,immunoreactivity
R17118 T20025 T20028 nummod seven,patients
R17119 T20026 T20028 amod steroid-naïve,patients
R17120 T20027 T20028 compound asthma,patients
R17121 T20028 T20024 pobj patients,from
R17157 T20064 T20066 punct *,<
R17158 T20065 T20066 compound p,<
R17159 T20066 T20053 conj <,presented
R17160 T20067 T20071 nummod 0.05,test
R17161 T20068 T20071 poss Wilcoxon,test
R17162 T20069 T20068 case 's,Wilcoxon
R17163 T20070 T20071 compound rank,test
R17164 T20071 T20066 appos test,<
R17165 T20072 T20071 prep compared,test
R17166 T20073 T20072 prep with,compared
R17167 T20074 T20073 pobj placebo,with
R17168 T20075 T20053 punct .,presented
R17169 T20076 T20080 punct (,analyses
R17170 T20077 T20080 compound C,analyses
R17171 T20078 T20079 punct ),Immunoblotting
R17172 T20079 T20080 compound Immunoblotting,analyses
R17173 T20080 T20083 nsubj analyses,demonstrated
R17174 T20081 T20080 prep of,analyses
R17175 T20082 T20081 pobj PBMCs,of
R17176 T20083 T20083 ROOT demonstrated,demonstrated
R17177 T20084 T20086 det a,decrease
R17178 T20085 T20086 amod time-dependent,decrease
R17179 T20086 T20083 dobj decrease,demonstrated
R17180 T20087 T20086 prep in,decrease
R17181 T20088 T20089 amod nuclear,expression
R17182 T20089 T20087 pobj expression,in
R17183 T20090 T20089 prep of,expression
R17184 T20091 T20090 pobj GATA-3,of
R17185 T20092 T20083 punct ",",demonstrated
R17186 T20093 T20083 cc and,demonstrated
R17187 T20094 T20097 amod increased,expression
R17188 T20095 T20097 amod cytoplasmic,expression
R17189 T20096 T20097 amod GATA-3,expression
R17190 T20097 T20083 conj expression,demonstrated
R17191 T20098 T20097 prep after,expression
R17192 T20099 T20098 pobj inhalation,after
R17193 T20100 T20099 prep of,inhalation
R17194 T20101 T20100 pobj FP,of
R17195 T20102 T20083 punct .,demonstrated
R17196 T20103 T20110 punct (,demonstrated
R17197 T20104 T20107 compound D,analyses
R17198 T20105 T20106 punct ),Immunoblotting
R17199 T20106 T20107 compound Immunoblotting,analyses
R17237 T20144 T20147 amod nuclear,fractions
R17238 T20145 T20144 cc and,nuclear
R17239 T20146 T20144 conj cytoplasmic,nuclear
R17240 T20147 T20142 pobj fractions,for
R17241 T20148 T20137 advmod respectively,confirmed
R17242 T20149 T20137 punct .,confirmed
R17243 T20150 T20164 nsubjpass Quantification,shown
R17244 T20151 T20150 prep of,Quantification
R17245 T20152 T20154 det the,data
R17246 T20153 T20154 compound densitometry,data
R17247 T20154 T20151 pobj data,of
R17248 T20155 T20154 prep in,data
R17249 T20156 T20157 punct (,C
R17250 T20157 T20155 pobj C,in
R17251 T20158 T20150 punct ),Quantification
R17252 T20159 T20150 cc and,Quantification
R17253 T20160 T20161 punct (,D
R17254 T20161 T20150 conj D,Quantification
R17255 T20162 T20161 punct ),D
R17256 T20163 T20164 auxpass is,shown
R17257 T20164 T20164 ROOT shown,shown
R17258 T20165 T20164 prep as,shown
R17259 T20166 T20168 det a,plot
R17260 T20167 T20168 compound box-and-whiskers,plot
R17261 T20168 T20165 pobj plot,as
R17262 T20169 T20168 prep of,plot
R17263 T20170 T20169 pobj results,of
R17264 T20171 T20170 prep from,results
R17265 T20172 T20175 amod n,participants
R17266 T20173 T20174 punct =,6
R17267 T20174 T20175 nummod 6,participants
R17268 T20175 T20171 pobj participants,from
R17269 T20176 T20179 prep for,were
R17270 T20177 T20176 pobj which,for
R17271 T20178 T20179 nsubj data,were
R17272 T20179 T20175 relcl were,participants
R17273 T20180 T20179 acomp available,were
R17274 T20181 T20164 punct .,shown
R17275 T20182 T20186 advmod *,compared
R17276 T20183 T20184 compound p,<
R17277 T20184 T20185 compound <,0.05
R17278 T20185 T20186 advmod 0.05,compared
R17315 T20222 T20223 det The,results
R17316 T20223 T20229 nsubj results,are
R17317 T20224 T20223 acl shown,results
R17318 T20225 T20224 prep in,shown
R17319 T20226 T20227 punct (,E
R17320 T20227 T20225 pobj E,in

UBERON-AE

Id Subject Object Predicate Lexical cue
T11222 13737-13742 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T11223 13939-13944 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GO-BP

Id Subject Object Predicate Lexical cue
T8657 151-166 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T8658 276-290 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T8659 688-697 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T9278 2837-2851 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T9279 3405-3419 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T10687 5127-5130 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10688 5131-5135 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10689 5242-5246 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10690 5408-5412 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10691 5223-5234 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10692 5247-5258 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10693 5338-5353 http://purl.obolibrary.org/obo/GO_0001775 denotes cells activated
T10694 5413-5428 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10695 5466-5481 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10696 5656-5671 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10697 5798-5813 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10698 6062-6076 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T10699 8230-8244 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T10700 9926-9940 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T10701 7784-7790 http://purl.obolibrary.org/obo/GO_0085030 denotes mutual
T10702 9420-9434 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10703 9484-9498 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10704 9874-9888 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10705 9442-9453 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T10706 9557-9569 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12574 12613-12628 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T12575 16728-16743 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T12576 13691-13699 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T12577 13700-13712 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12578 16320-16332 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12579 14668-14671 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T12580 14672-14676 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12581 16530-16534 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12582 14677-14692 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12583 16551-16566 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12584 16691-16705 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T16601 1207-1222 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T16602 1243-1257 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T16603 1603-1615 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T16604 1822-1826 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T16605 2049-2051 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T17414 3649-3663 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T17415 4875-4894 http://purl.obolibrary.org/obo/GO_0002672 denotes cells stimulated (b
T17416 4875-4894 http://purl.obolibrary.org/obo/GO_0045579 denotes cells stimulated (b
T17417 4875-4894 http://purl.obolibrary.org/obo/GO_0002869 denotes cells stimulated (b
T17418 4875-4894 http://purl.obolibrary.org/obo/GO_0002904 denotes cells stimulated (b
T17419 4875-4894 http://purl.obolibrary.org/obo/GO_0050871 denotes cells stimulated (b
T17420 4875-4894 http://purl.obolibrary.org/obo/GO_0031296 denotes cells stimulated (b
T17421 4875-4894 http://purl.obolibrary.org/obo/GO_0030890 denotes cells stimulated (b
T18100 6286-6289 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18101 6542-6545 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18102 6718-6721 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18103 6546-6550 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18104 6722-6726 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18105 6770-6774 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18106 6301-6316 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18107 6393-6408 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18108 6490-6505 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18109 6644-6659 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18110 6863-6878 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18111 6301-6331 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation and activation
T18112 6644-6672 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation of activated
T18113 6365-6375 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T18114 6663-6693 http://purl.obolibrary.org/obo/GO_0051091 denotes activated transcription factor
T18115 6663-6693 http://purl.obolibrary.org/obo/GO_0032793 denotes activated transcription factor
T18116 6663-6693 http://purl.obolibrary.org/obo/GO_1901485 denotes activated transcription factor
T18117 6673-6686 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T18118 6752-6774 http://purl.obolibrary.org/obo/GO_1903753 denotes inhibition of p38 MAPK
T18536 8492-8510 http://purl.obolibrary.org/obo/GO_0005049 denotes importin-α binding
T19149 10145-10159 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T19150 10204-10218 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T19151 10343-10355 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T19152 2363-10477 http://purl.obolibrary.org/obo/GO_0031296 denotes stimulated. (E) FP (10 nM) reduces the ability of anti-CD3/CD28-stimulated GATA-3 to associate with the native IL-5 promoter 60 min after stimulation. Data are also shown graphically as mean±SEM of three independent experiments. All data were analysed by ANOVA followed by Newman-Keuls post-test. Ligand-Activated GR Competes with GATA-3 for Importin-α We confirmed and extended previous data [20] to show that ligand-activated GR as well as GATA-3 uses importin-α for its nuclear import (Figure 2A and 2B). This interaction between GR and importin-α was significant at concentrations as low as 10−12 M and was maximal with 10−8 M FP. Subsequent GR nuclear translocation was rapid and sustained at significant levels for at least 14 h (Figure 2B). Using IP-Western blotting we showed that FP at 10−12–10−8 M decreased the association between GATA-3 and importin-α induced by anti-CD3/CD28 stimulation in a concentration-dependent manner (Figure 2C). In addition, using GFP-labelled GATA-3 and confocal microscopy we demonstrated that GATA-3 nuclear import following anti-CD3/CD28 stimulation for 30 min was attenuated by pretreatment with FP (10−8 M) (Figure 2D). 10.1371/journal.pmed.1000076.g002 Figure 2 Fluticasone propionate reduces GATA-3 association with importin-α and GATA-3 nuclear import. (A) Western blot analysis demonstrates a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR interaction with importin-α (Imp-α). A positive control for GR association with importin is shown. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. *** p<0.001 compared to control, ### p<0.001. (B) Western blot analysis demonstrated a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR nuclear translocation measured by IP. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. ***p<0.001 compared to control. (C) Western blot analysis of HuT-78 cells treated with FP and anti-CD3/CD28 co-stimulation demonstrated a concentration-dependent decrease in GATA-3–importin-α association at 20 min. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) GFP-tagged GATA-3 was overexpressed and cells stimulated (b, c) or not (a) for 30 min with anti-CD3/CD28. The effect of 30 min pretreatment of cells with FP (10−8 M, c) is also shown. All data were analysed by ANOVA followed by Newman-Keuls post-test. Effect on MKP-1 Dexamethasone inhibits p38 MAPK function in a cell type–specific manner through the rapid induction of the dual kinase phosphatase MKP-1 (MAPK phosphatase-1), and this effect lasts for up to 24 h [28]. FP (10−8 M) treatment of HuT-78 cells activated by anti-CD3/CD28 in vitro significantly decreased p38 MAPK phosphorylation (Figure 3A) and activity measured by phosphorylation of the downstream target ATF-2 (Figure 3B). This effect was detected at 30 min and lasted for at least 14 h (Figure 3B). FP (10−8 M) also significantly reduced GATA-3 serine phosphorylation induced by anti-CD3/CD28 stimulation in both a time- and concentration-dependent manner (Figure 3C). This reduction in GATA-3 phosphorylation was also seen with lower concentrations of FP. We found that FP significantly induced MKP-1 mRNA in both a time- and concentration-dependent manner, reaching a plateau at 10−8 M after 10 min (Figure 3D and 3E). However, the effects of FP on GATA-3 nuclear import, importin-α association and IL-4 mRNA expression are seen at 10,000-fold lower concentrations (10−12 M, see Figure 2). 10.1371/journal.pmed.1000076.g003 Figure 3 Fluticasone propionate–mediated inhibition of p38 MAP kinase phosphorylation and activation is associated with a marked down-regulation of GATA-3 serine phosphorylation. (A) Western blot analysis shows that FP (10−8 M, 30 min) treatment reduced dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK in anti-CD3/CD28–co-stimulated HuT-78 cells. (B) Time course of the effect of FP (10−8 M) on phosphorylation of activated transcription factor 2 (ATF-2), a measure of p38 MAPK activity. (C) FP-induced inhibition of p38 MAPK activity is associated with the decrease of anti-CD3/CD28 co-stimulation–induced serine phosphorylation (P-Ser) of GATA-3. For (A–C), quantification of the densitometry data is also shown. Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) FP induced MKP-1 mRNA in a concentration-dependent manner. All results are representative of at least three independent experiments and where appropriate expressed as means±SEM, *p<0.05. (E) FP induces MKP-1 mRNA in a time-dependent manner. Results are representative of two independent experiments. All data except (E) were analysed by ANOVA followed by Newman-Keuls post-test. Using an in vitro competition assay (Figure 4A) utilizing purified activated GATA-3, importin-α, and activated GR, we demonstrated that activated GR significantly increased GR-importin-α association in the presence and absence of activated GATA-3 (Figure 4B). This effect is not mutual, since activated GATA-3 did not block GR–importin-α association (Figure 4C). These data also suggest that both activated GR and phospho-GATA-3 can directly associate with importin-α (Figure 4D) and that activated GR attenuates the phospho-GATA-3/importin-α interaction in a concentration-dependent manner (Figure 4E). Together, this suggests that ligand-activated GR may compete with phospho-GATA-3 for importin-α and thereby limit GATA-3 nuclear import. 10.1371/journal.pmed.1000076.g004 Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α. (A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p<0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p<0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p<0.05 compared to GATA-3 isolated from unstimulated cells. # p<0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p<0.05, **p<0.01 between groups. All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test. Other possible interpretations of our results could include an effect of FP on GATA-3 nuclear export and/or degradation. Leptomycin B, which inhibits nuclear export, did not affect the ability of FP to block GATA-3 nuclear localization (Figure 5A). Additionally, FP had no effect on whole cell GATA-3 expression during the time course of these experiments (Figure 5B). Nor did addition of FP subsequent to anti-CD3/CD28 nuclear translocation affect GATA-3 nuclear residency (Figure 5C), suggesting that activated GR does not enhance GATA-3 nuclear export. Finally, the effect of FP on GATA-3 nuclear import was not nonspecific, since FP (10−8 M) had no effect on p65 nuclear translocation measured at 60 min (Figure 5D). 10.1371/journal.pmed.1000076.g005 Figure 5 Fluticasone propionate does not affect GATA-3 nuclear export. (A) Western blot analysis showing that the nuclear export inhibitor leptomycin B (2 nM) does not affect the ability of FP (10−8 M) to prevent anti-CD3/CD28–stimulated GATA-3 nuclear localization measured at 60 min. ***p<0.001 compared to unstimulated cells, ### p<0.001 compared to anti-CD3/CD28–stimulated cells. (B
T19153 10626-10645 http://purl.obolibrary.org/obo/GO_0031296 denotes cells stimulated (b
T19154 10560-10571 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T19155 10626-10645 http://purl.obolibrary.org/obo/GO_0002672 denotes cells stimulated (b
T19156 10626-10645 http://purl.obolibrary.org/obo/GO_0045579 denotes cells stimulated (b
T19157 10626-10645 http://purl.obolibrary.org/obo/GO_0002869 denotes cells stimulated (b
T19158 10626-10645 http://purl.obolibrary.org/obo/GO_0002904 denotes cells stimulated (b
T19159 10626-10645 http://purl.obolibrary.org/obo/GO_0050871 denotes cells stimulated (b
T19160 10626-10645 http://purl.obolibrary.org/obo/GO_0030890 denotes cells stimulated (b
T19579 11711-11723 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T20243 14867-14879 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T20244 14999-15011 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T20245 16081-16096 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T20246 16133-16136 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T20247 16137-16141 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

GO-MF

Id Subject Object Predicate Lexical cue
T8660 75-79 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T8661 146-150 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T8662 1000-1004 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T8663 1009-1013 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T8664 1085-1089 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T8665 1063-1070 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T9280 2661-2667 http://purl.obolibrary.org/obo/GO_0005488 denotes Ligand
T9281 2775-2781 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T10707 5127-5130 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10708 5131-5135 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10709 5242-5246 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10710 5408-5412 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10711 5223-5234 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10712 5247-5258 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10713 6105-6109 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T10714 8138-8144 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T12589 12601-12605 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T12590 14668-14671 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T12591 14672-14676 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12592 16530-16534 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T16606 1822-1826 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T16607 2049-2051 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T16608 2081-2085 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16609 2090-2094 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T16610 2474-2478 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T18119 6286-6289 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18120 6542-6545 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18121 6718-6721 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18122 6546-6550 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18123 6722-6726 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18124 6770-6774 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18125 6663-6693 http://purl.obolibrary.org/obo/GO_0033613 denotes activated transcription factor
T18537 8403-8410 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18538 8503-8510 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18539 8900-8907 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18540 9024-9031 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18541 8492-8510 http://purl.obolibrary.org/obo/GO_0005049 denotes importin-α binding
T20250 16133-16136 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T20251 16137-16141 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK

GO-CC

Id Subject Object Predicate Lexical cue
T8666 317-322 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12593 12546-12550 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T12594 13745-13750 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12595 13947-13952 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12596 14706-14711 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16614 1347-1356 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T16615 1364-1371 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T18542 8474-8479 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18543 8656-8661 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18544 8839-8844 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18545 8969-8974 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17422 4472-4477 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17423 4824-4829 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17424 4875-4880 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10715 5150-5154 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10716 9623-9627 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T16611 1297-1302 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16612 1567-1572 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16613 2136-2141 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17425 4978-4983 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18126 6589-6594 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18127 4824-4829 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19161 10412-10417 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19162 10468-10473 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19163 10626-10631 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19164 10703-10708 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19165 10937-10942 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T8238 9-84 Sentence denotes The Effect of Corticosteroids on GATA-3 Nuclear Translocation and IL-4 mRNA
T8239 85-193 Sentence denotes Corticosteroids are effective in inhibiting GATA-3-regulated IL-4 gene expression in vitro and in vivo [32].
T8240 194-301 Sentence denotes We therefore investigated whether corticosteroids affect anti-CD3/CD28–stimulated nuclear import of GATA-3.
T8241 302-453 Sentence denotes Stimulation of cells with anti-CD3/CD28 resulted in a rapid cytoplasmic/nuclear GATA-3 translocation (Figure 1A), confirming our previous results [12].
T8242 454-583 Sentence denotes We also confirmed a clear separation of nuclear and cytosolic fractions as indicated by histone H1 and MEK-1 markers (Figure 1B).
T8243 584-795 Sentence denotes The potent topical corticosteroid FP caused sustained loss of nuclear GATA-3 expression and cytoplasmic retention of GATA-3 at concentrations ranging from 10−12 to 10−8 M, which cover the therapeutic range [37].
T8244 796-1111 Sentence denotes This effect was concentration- and time-dependent, with a peak effect of 11.6-fold at 30 min at a concentration of 10−8 M (Figure 1C) and was associated with marked reductions in anti-CD3/CD28–stimulated IL-4 and IL-5 mRNA expression (Figure 1D) and a loss of GATA-3 binding to the native IL-5 promoter (Figure 1E).
T8940 2661-2716 Sentence denotes Ligand-Activated GR Competes with GATA-3 for Importin-α
T8941 2717-2871 Sentence denotes We confirmed and extended previous data [20] to show that ligand-activated GR as well as GATA-3 uses importin-α for its nuclear import (Figure 2A and 2B).
T8942 2872-2998 Sentence denotes This interaction between GR and importin-α was significant at concentrations as low as 10−12 M and was maximal with 10−8 M FP.
T8943 2999-3111 Sentence denotes Subsequent GR nuclear translocation was rapid and sustained at significant levels for at least 14 h (Figure 2B).
T8944 3112-3313 Sentence denotes Using IP-Western blotting we showed that FP at 10−12–10−8 M decreased the association between GATA-3 and importin-α induced by anti-CD3/CD28 stimulation in a concentration-dependent manner (Figure 2C).
T8945 3314-3527 Sentence denotes In addition, using GFP-labelled GATA-3 and confocal microscopy we demonstrated that GATA-3 nuclear import following anti-CD3/CD28 stimulation for 30 min was attenuated by pretreatment with FP (10−8 M) (Figure 2D).
T9693 7505-7764 Sentence denotes Using an in vitro competition assay (Figure 4A) utilizing purified activated GATA-3, importin-α, and activated GR, we demonstrated that activated GR significantly increased GR-importin-α association in the presence and absence of activated GATA-3 (Figure 4B).
T9694 7765-7867 Sentence denotes This effect is not mutual, since activated GATA-3 did not block GR–importin-α association (Figure 4C).
T9695 7868-8108 Sentence denotes These data also suggest that both activated GR and phospho-GATA-3 can directly associate with importin-α (Figure 4D) and that activated GR attenuates the phospho-GATA-3/importin-α interaction in a concentration-dependent manner (Figure 4E).
T9696 8109-8245 Sentence denotes Together, this suggests that ligand-activated GR may compete with phospho-GATA-3 for importin-α and thereby limit GATA-3 nuclear import.
T9697 9334-9454 Sentence denotes Other possible interpretations of our results could include an effect of FP on GATA-3 nuclear export and/or degradation.
T9698 9455-9582 Sentence denotes Leptomycin B, which inhibits nuclear export, did not affect the ability of FP to block GATA-3 nuclear localization (Figure 5A).
T9699 9583-9702 Sentence denotes Additionally, FP had no effect on whole cell GATA-3 expression during the time course of these experiments (Figure 5B).
T9700 9703-9889 Sentence denotes Nor did addition of FP subsequent to anti-CD3/CD28 nuclear translocation affect GATA-3 nuclear residency (Figure 5C), suggesting that activated GR does not enhance GATA-3 nuclear export.
T9701 9890-10054 Sentence denotes Finally, the effect of FP on GATA-3 nuclear import was not nonspecific, since FP (10−8 M) had no effect on p65 nuclear translocation measured at 60 min (Figure 5D).
T11291 11106-11222 Sentence denotes The Inhibitory Effect of Corticosteroids on GATA-3 Nuclear Localization in Primary T Lymphocytes Ex Vivo and In Vivo
T11292 11223-11581 Sentence denotes Treatment with FP ex vivo demonstrated a concentration-dependent decrease in the direct interaction between phospho-GATA-3 and importin-α in PBMCs from patients with asthma (Figure 6A and 6B), which was significantly inhibited at 10−12 M FP (p<0.001, ANOVA and Newman-Keuls test) and completely attenuated by 10−8 M FP (p<0.001, ANOVA and Newman-Keuls test).
T11293 12531-12709 Sentence denotes Our previous T cell line studies indicated that 10−12 M FP suppresses IL-4 and -5 gene expression and attenuated the interaction of GATA-3 with importin-α (see Figures 1D and 2).
T11294 12710-12831 Sentence denotes This concentration is close to peak plasma levels obtained from asthmatic patients treated with inhaled FP (500 µg) [27].
T11295 12832-12988 Sentence denotes Inhaled FP (500 µg) treatment of seven steroid-naive asthma patients significantly reduced GATA-3–importin-α interaction in vivo in a time-dependent manner.
T11296 12989-13151 Sentence denotes This produced a >90% decrease in GATA-3–importin-α association at 2 h (median [95% CI], 13,494 [6,828–17,829] versus 879 [597–1,165]; p<0.05 Friedman's analysis).
T11297 13152-13284 Sentence denotes However, this did not reach significance using Wilcoxon's post-test analysis (W = 6.00) probably due to low numbers of participants.
T11298 13285-13382 Sentence denotes Similar results were observed when GATA-3–importin-α association was measured (Figure 6C and 6D).
T11299 13383-13431 Sentence denotes The lower dose of FP (100 µg) was not effective.
T11300 13432-13638 Sentence denotes The attenuated interaction of GATA-3 did not result from the defective recycling of importin-α, as a significant decrease in the abundance of importin-α in the cytoplasmic pool was not detected (Figure 6E).
T11301 13639-13751 Sentence denotes We further examined whether inhaled FP could affect cellular localization of GATA-3 in peripheral blood T cells.
T11302 13752-14102 Sentence denotes Treatment with inhaled FP (500 µg) for 2 h significantly increased GR nuclear translocation (Figure 7A) and concomitantly decreased the number of nuclear GATA-3 immunoreactive peripheral blood T cells (37%±4.2% versus 58.2%±4.95%, p = 0.016, W = 28.0, Wilcoxon's rank test) compared with placebo as measured by immunocytochemistry (Figure 7A and 7B).
T11303 14103-14234 Sentence denotes This was confirmed by Western blotting, which also indicated that this effect was both time- and dose-dependent (Figure 7C and 7D).
T11304 14235-14632 Sentence denotes Thus, inhaled FP (500 µg) induced significant loss in nuclear GATA-3 at 2 h (median [95% CI], 0.40 [0.27–0.53] versus 0.14 [0.11–0.19], p<0.05, W = 21.00, Wilcoxon's rank test) (Figure 7C) and cytoplasmic GATA-3 levels were enhanced by inhaled FP in a dose-dependent manner (median [95% CI], 0.0032 [0.0026–0.0039] versus 0.658 [0.592–0.720], p<0.05, W = −21.00, Wilcoxon's rank test) (Figure 7D).
T11305 14633-14768 Sentence denotes In addition, FP (500 µg) inhibited p38 MAPK phosphorylation in primary T cells in vivo at 2 h in samples from two patients (Figure 7E).
T11306 16255-16409 Sentence denotes Taken together, our data suggest that inhaled FP reduces nuclear localization of GATA-3 in vivo by acutely inhibiting phospho-GATA-3–importin association.
T11307 16410-16596 Sentence denotes This effect may be direct, through competition for importin-α or associated molecules, or secondary to an effect on p38 MAPK-mediated GATA-3 phosphorylation via rapid induction of MKP-1.
T11308 16597-16744 Sentence denotes The combination of these two interacting effects can result in complete suppression of GATA-3 nuclear import and thus Th2 cytokine gene expression.
T16029 1156-1258 Sentence denotes Fluticasone propionate down-regulates Th2 cytokine gene expression and inhibits GATA-3 nuclear import.
T16030 1259-1758 Sentence denotes (A) Anti-CD3/CD28 treatment of HuT-78 cells results in translocation of GATA-3 from the cytoplasm to the nucleus within 30 min. (B) Histone H1 and MEK-1 were used to confirm distinct separation of cytoplasmic and nuclear extracts in three separate experiments. (C) Western blot analysis of FP-treated HuT-78 cells demonstrated impaired nuclear localization of GATA-3 induced by anti-CD3/CD28 co-stimulation in a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent manner.
T16031 1759-1821 Sentence denotes Cells were pretreated with FP for 30 min prior to stimulation.
T16032 1822-1918 Sentence denotes MEK1 and histone H1 were used to demonstrate equal cytoplasmic and nuclear loading respectively.
T16033 1919-2142 Sentence denotes Results are presented graphically below as mean±SEM of at least three independent experiments. *** p<0.001 compared to t = 0. (D) RT-PCR showing that FP inhibits IL-4 and IL-5 mRNA expression in CD3/CD28-costimulated cells.
T16034 2143-2179 Sentence denotes GAPDH was used as a loading control.
T16035 2180-2513 Sentence denotes Lower panels show graphical analysis of results presented as mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to anti-CD3/CD28–stimulated. (E) FP (10 nM) reduces the ability of anti-CD3/CD28-stimulated GATA-3 to associate with the native IL-5 promoter 60 min after stimulation.
T16036 2514-2591 Sentence denotes Data are also shown graphically as mean±SEM of three independent experiments.
T16037 2592-2659 Sentence denotes All data were analysed by ANOVA followed by Newman-Keuls post-test.
T18308 8290-8357 Sentence denotes Fluticasone propionate competes with phospho-GATA-3 for importin-α.
T18309 8358-9202 Sentence denotes (A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p<0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p<0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p<0.05 compared to GATA-3 isolated from unstimulated cells. # p<0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p<0.05, **p<0.01 between groups.
T18310 9203-9331 Sentence denotes All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test.
T18713 10099-10160 Sentence denotes Fluticasone propionate does not affect GATA-3 nuclear export.
T18714 10161-10679 Sentence denotes (A) Western blot analysis showing that the nuclear export inhibitor leptomycin B (2 nM) does not affect the ability of FP (10−8 M) to prevent anti-CD3/CD28–stimulated GATA-3 nuclear localization measured at 60 min. ***p<0.001 compared to unstimulated cells, ### p<0.001 compared to anti-CD3/CD28–stimulated cells. (B) Western blot analysis showing that FP (10−8 M) does not affect whole-cell GATA-3 degradation over 17 h. (C) GFP-tagged GATA-3 is overexpressed and cells stimulated (b–j) or not (a) with anti-CD3/CD28.
T18715 10680-10943 Sentence denotes The effect of treating cells with FP (10−8 M, f–j) after 30 min stimulation with anti-CD3/CD28 is also shown. (D) FP (10−8 M) does not prevent anti-CD3/CD28–stimulated p65 nuclear translocation at 60 min after stimulation. **p<0.01 compared to unstimulated cells.
T18716 10944-11042 Sentence denotes All results are representative of at least four independent experiments and are shown as mean±SEM.
T18717 11043-11104 Sentence denotes Results were analysed by ANOVA followed by Newman-Keuls test.
T19286 11626-11744 Sentence denotes Fluticasone propionate impairs GATA-3 interaction with importin-α and GATA-3 nuclear localization in vivo and ex vivo.
T19287 11745-11939 Sentence denotes (A and B) Co-immunoprecipitation analysis of PBMCs from steroid-naïve asthma patients treated with FP in vitro demonstrated impaired interaction between GATA-3 and importin-α measured at 60 min.
T19288 11940-12301 Sentence denotes Each bar represents the mean±SEM of at least three independent experiments; *** p<0.001 compared with control as determined by ANOVA/Newman-Keuls analysis. (C and D) Co-immunoprecipitation analyses of PBMCs from steroid-naïve asthma patients treated with inhaled FP (500 µg via a spacer) in vivo demonstrated decreased association between GATA-3 and importin-α.
T19289 12302-12472 Sentence denotes The individual values for each treatment are presented graphically. (E) Representative Western blot showing that importin-α expression was unaffected by inhalation of FP.
T19290 12473-12528 Sentence denotes Blot is representative of gels from three participants.
T19726 14813-14889 Sentence denotes Inhaled fluticasone propionate impairs GATA-3 nuclear localization in PBMCs.
T19727 14890-15161 Sentence denotes (A) Representative immunocytochemistry of showing the effect of inhaled FP (500 µg) on GR and GATA-3 nuclear localisation. (B) Nuclear GATA-3 immunoreactivity in PBMCs from seven steroid-naïve asthma patients 2 h following inhaled FP treatment (100 or 500 µg via spacer).
T19728 15162-15677 Sentence denotes The median and interquartile ranges for each treatment are presented as a box-and-whiskers plot (n = 7); * p<0.05 Wilcoxon's rank test compared with placebo. (C) Immunoblotting analyses of PBMCs demonstrated a time-dependent decrease in nuclear expression of GATA-3, and increased cytoplasmic GATA-3 expression after inhalation of FP. (D) Immunoblotting analyses of PBMCs demonstrated a dose-dependent decrease in nuclear expression of GATA-3, and increased cytoplasmic GATA-3 expression 2 h after inhalation of FP.
T19729 15678-15812 Sentence denotes Histone H1 and MEK-1 immunoblotting confirmed equivalent total protein loading for the nuclear and cytoplasmic fractions respectively.
T19730 15813-16174 Sentence denotes Quantification of the densitometry data in (C) and (D) is shown as a box-and-whiskers plot of results from n = 6 participants for which data were available. *p<0.05 compared to control. (E) Western blot analyses of PBMCs demonstrated a time-dependent decrease in dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK after inhalation of FP (500 µg).
T19731 16175-16252 Sentence denotes The results shown in (E) are representative of samples from two participants.
T9685 5088-5103 Sentence denotes Effect on MKP-1
T9686 5104-5305 Sentence denotes Dexamethasone inhibits p38 MAPK function in a cell type–specific manner through the rapid induction of the dual kinase phosphatase MKP-1 (MAPK phosphatase-1), and this effect lasts for up to 24 h [28].
T9687 5306-5525 Sentence denotes FP (10−8 M) treatment of HuT-78 cells activated by anti-CD3/CD28 in vitro significantly decreased p38 MAPK phosphorylation (Figure 3A) and activity measured by phosphorylation of the downstream target ATF-2 (Figure 3B).
T9688 5526-5602 Sentence denotes This effect was detected at 30 min and lasted for at least 14 h (Figure 3B).
T9689 5603-5772 Sentence denotes FP (10−8 M) also significantly reduced GATA-3 serine phosphorylation induced by anti-CD3/CD28 stimulation in both a time- and concentration-dependent manner (Figure 3C).
T9690 5773-5860 Sentence denotes This reduction in GATA-3 phosphorylation was also seen with lower concentrations of FP.
T9691 5861-6024 Sentence denotes We found that FP significantly induced MKP-1 mRNA in both a time- and concentration-dependent manner, reaching a plateau at 10−8 M after 10 min (Figure 3D and 3E).
T9692 6025-6195 Sentence denotes However, the effects of FP on GATA-3 nuclear import, importin-α association and IL-4 mRNA expression are seen at 10,000-fold lower concentrations (10−12 M, see Figure 2).
T16815 3572-3664 Sentence denotes Fluticasone propionate reduces GATA-3 association with importin-α and GATA-3 nuclear import.
T16816 3665-3851 Sentence denotes (A) Western blot analysis demonstrates a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR interaction with importin-α (Imp-α).
T16817 3852-3913 Sentence denotes A positive control for GR association with importin is shown.
T16818 3914-3969 Sentence denotes Quantification of the densitometry data is shown below.
T16819 3970-4275 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. *** p<0.001 compared to control, ### p<0.001. (B) Western blot analysis demonstrated a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR nuclear translocation measured by IP.
T16820 4276-4331 Sentence denotes Quantification of the densitometry data is shown below.
T16821 4332-4618 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ***p<0.001 compared to control. (C) Western blot analysis of HuT-78 cells treated with FP and anti-CD3/CD28 co-stimulation demonstrated a concentration-dependent decrease in GATA-3–importin-α association at 20 min.
T16822 4619-4674 Sentence denotes Quantification of the densitometry data is shown below.
T16823 4675-4940 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) GFP-tagged GATA-3 was overexpressed and cells stimulated (b, c) or not (a) for 30 min with anti-CD3/CD28.
T16824 4941-5018 Sentence denotes The effect of 30 min pretreatment of cells with FP (10−8 M, c) is also shown.
T16825 5019-5086 Sentence denotes All data were analysed by ANOVA followed by Newman-Keuls post-test.
T17603 6240-6409 Sentence denotes Fluticasone propionate–mediated inhibition of p38 MAP kinase phosphorylation and activation is associated with a marked down-regulation of GATA-3 serine phosphorylation.
T17604 6410-6897 Sentence denotes (A) Western blot analysis shows that FP (10−8 M, 30 min) treatment reduced dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK in anti-CD3/CD28–co-stimulated HuT-78 cells. (B) Time course of the effect of FP (10−8 M) on phosphorylation of activated transcription factor 2 (ATF-2), a measure of p38 MAPK activity. (C) FP-induced inhibition of p38 MAPK activity is associated with the decrease of anti-CD3/CD28 co-stimulation–induced serine phosphorylation (P-Ser) of GATA-3.
T17605 6898-6963 Sentence denotes For (A–C), quantification of the densitometry data is also shown.
T17606 6964-7182 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) FP induced MKP-1 mRNA in a concentration-dependent manner.
T17607 7183-7364 Sentence denotes All results are representative of at least three independent experiments and where appropriate expressed as means±SEM, *p<0.05. (E) FP induces MKP-1 mRNA in a time-dependent manner.
T17608 7365-7423 Sentence denotes Results are representative of two independent experiments.
T17609 7424-7502 Sentence denotes All data except (E) were analysed by ANOVA followed by Newman-Keuls post-test.
T166 0-7 Sentence denotes Results
T167 9-84 Sentence denotes The Effect of Corticosteroids on GATA-3 Nuclear Translocation and IL-4 mRNA
T168 85-193 Sentence denotes Corticosteroids are effective in inhibiting GATA-3-regulated IL-4 gene expression in vitro and in vivo [32].
T169 194-301 Sentence denotes We therefore investigated whether corticosteroids affect anti-CD3/CD28–stimulated nuclear import of GATA-3.
T170 302-453 Sentence denotes Stimulation of cells with anti-CD3/CD28 resulted in a rapid cytoplasmic/nuclear GATA-3 translocation (Figure 1A), confirming our previous results [12].
T171 454-583 Sentence denotes We also confirmed a clear separation of nuclear and cytosolic fractions as indicated by histone H1 and MEK-1 markers (Figure 1B).
T172 584-795 Sentence denotes The potent topical corticosteroid FP caused sustained loss of nuclear GATA-3 expression and cytoplasmic retention of GATA-3 at concentrations ranging from 10−12 to 10−8 M, which cover the therapeutic range [37].
T173 796-1111 Sentence denotes This effect was concentration- and time-dependent, with a peak effect of 11.6-fold at 30 min at a concentration of 10−8 M (Figure 1C) and was associated with marked reductions in anti-CD3/CD28–stimulated IL-4 and IL-5 mRNA expression (Figure 1D) and a loss of GATA-3 binding to the native IL-5 promoter (Figure 1E).
T174 1112-1258 Sentence denotes 10.1371/journal.pmed.1000076.g001 Figure 1 Fluticasone propionate down-regulates Th2 cytokine gene expression and inhibits GATA-3 nuclear import.
T175 1259-1758 Sentence denotes (A) Anti-CD3/CD28 treatment of HuT-78 cells results in translocation of GATA-3 from the cytoplasm to the nucleus within 30 min. (B) Histone H1 and MEK-1 were used to confirm distinct separation of cytoplasmic and nuclear extracts in three separate experiments. (C) Western blot analysis of FP-treated HuT-78 cells demonstrated impaired nuclear localization of GATA-3 induced by anti-CD3/CD28 co-stimulation in a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent manner.
T176 1759-1821 Sentence denotes Cells were pretreated with FP for 30 min prior to stimulation.
T177 1822-1918 Sentence denotes MEK1 and histone H1 were used to demonstrate equal cytoplasmic and nuclear loading respectively.
T178 1919-2142 Sentence denotes Results are presented graphically below as mean±SEM of at least three independent experiments. *** p<0.001 compared to t = 0. (D) RT-PCR showing that FP inhibits IL-4 and IL-5 mRNA expression in CD3/CD28-costimulated cells.
T179 2143-2179 Sentence denotes GAPDH was used as a loading control.
T180 2180-2513 Sentence denotes Lower panels show graphical analysis of results presented as mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to anti-CD3/CD28–stimulated. (E) FP (10 nM) reduces the ability of anti-CD3/CD28-stimulated GATA-3 to associate with the native IL-5 promoter 60 min after stimulation.
T181 2514-2591 Sentence denotes Data are also shown graphically as mean±SEM of three independent experiments.
T182 2592-2659 Sentence denotes All data were analysed by ANOVA followed by Newman-Keuls post-test.
T183 2661-2716 Sentence denotes Ligand-Activated GR Competes with GATA-3 for Importin-α
T184 2717-2871 Sentence denotes We confirmed and extended previous data [20] to show that ligand-activated GR as well as GATA-3 uses importin-α for its nuclear import (Figure 2A and 2B).
T185 2872-2998 Sentence denotes This interaction between GR and importin-α was significant at concentrations as low as 10−12 M and was maximal with 10−8 M FP.
T186 2999-3111 Sentence denotes Subsequent GR nuclear translocation was rapid and sustained at significant levels for at least 14 h (Figure 2B).
T187 3112-3313 Sentence denotes Using IP-Western blotting we showed that FP at 10−12–10−8 M decreased the association between GATA-3 and importin-α induced by anti-CD3/CD28 stimulation in a concentration-dependent manner (Figure 2C).
T188 3314-3527 Sentence denotes In addition, using GFP-labelled GATA-3 and confocal microscopy we demonstrated that GATA-3 nuclear import following anti-CD3/CD28 stimulation for 30 min was attenuated by pretreatment with FP (10−8 M) (Figure 2D).
T189 3528-3664 Sentence denotes 10.1371/journal.pmed.1000076.g002 Figure 2 Fluticasone propionate reduces GATA-3 association with importin-α and GATA-3 nuclear import.
T190 3665-3851 Sentence denotes (A) Western blot analysis demonstrates a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR interaction with importin-α (Imp-α).
T191 3852-3913 Sentence denotes A positive control for GR association with importin is shown.
T192 3914-3969 Sentence denotes Quantification of the densitometry data is shown below.
T193 3970-4275 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. *** p<0.001 compared to control, ### p<0.001. (B) Western blot analysis demonstrated a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR nuclear translocation measured by IP.
T194 4276-4331 Sentence denotes Quantification of the densitometry data is shown below.
T195 4332-4618 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ***p<0.001 compared to control. (C) Western blot analysis of HuT-78 cells treated with FP and anti-CD3/CD28 co-stimulation demonstrated a concentration-dependent decrease in GATA-3–importin-α association at 20 min.
T196 4619-4674 Sentence denotes Quantification of the densitometry data is shown below.
T197 4675-4940 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) GFP-tagged GATA-3 was overexpressed and cells stimulated (b, c) or not (a) for 30 min with anti-CD3/CD28.
T198 4941-5018 Sentence denotes The effect of 30 min pretreatment of cells with FP (10−8 M, c) is also shown.
T199 5019-5086 Sentence denotes All data were analysed by ANOVA followed by Newman-Keuls post-test.
T200 5088-5103 Sentence denotes Effect on MKP-1
T201 5104-5305 Sentence denotes Dexamethasone inhibits p38 MAPK function in a cell type–specific manner through the rapid induction of the dual kinase phosphatase MKP-1 (MAPK phosphatase-1), and this effect lasts for up to 24 h [28].
T202 5306-5525 Sentence denotes FP (10−8 M) treatment of HuT-78 cells activated by anti-CD3/CD28 in vitro significantly decreased p38 MAPK phosphorylation (Figure 3A) and activity measured by phosphorylation of the downstream target ATF-2 (Figure 3B).
T203 5526-5602 Sentence denotes This effect was detected at 30 min and lasted for at least 14 h (Figure 3B).
T204 5603-5772 Sentence denotes FP (10−8 M) also significantly reduced GATA-3 serine phosphorylation induced by anti-CD3/CD28 stimulation in both a time- and concentration-dependent manner (Figure 3C).
T205 5773-5860 Sentence denotes This reduction in GATA-3 phosphorylation was also seen with lower concentrations of FP.
T206 5861-6024 Sentence denotes We found that FP significantly induced MKP-1 mRNA in both a time- and concentration-dependent manner, reaching a plateau at 10−8 M after 10 min (Figure 3D and 3E).
T207 6025-6195 Sentence denotes However, the effects of FP on GATA-3 nuclear import, importin-α association and IL-4 mRNA expression are seen at 10,000-fold lower concentrations (10−12 M, see Figure 2).
T208 6196-6409 Sentence denotes 10.1371/journal.pmed.1000076.g003 Figure 3 Fluticasone propionate–mediated inhibition of p38 MAP kinase phosphorylation and activation is associated with a marked down-regulation of GATA-3 serine phosphorylation.
T209 6410-6897 Sentence denotes (A) Western blot analysis shows that FP (10−8 M, 30 min) treatment reduced dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK in anti-CD3/CD28–co-stimulated HuT-78 cells. (B) Time course of the effect of FP (10−8 M) on phosphorylation of activated transcription factor 2 (ATF-2), a measure of p38 MAPK activity. (C) FP-induced inhibition of p38 MAPK activity is associated with the decrease of anti-CD3/CD28 co-stimulation–induced serine phosphorylation (P-Ser) of GATA-3.
T210 6898-6963 Sentence denotes For (A–C), quantification of the densitometry data is also shown.
T211 6964-7182 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) FP induced MKP-1 mRNA in a concentration-dependent manner.
T212 7183-7364 Sentence denotes All results are representative of at least three independent experiments and where appropriate expressed as means±SEM, *p<0.05. (E) FP induces MKP-1 mRNA in a time-dependent manner.
T213 7365-7423 Sentence denotes Results are representative of two independent experiments.
T214 7424-7502 Sentence denotes All data except (E) were analysed by ANOVA followed by Newman-Keuls post-test.
T215 7505-7764 Sentence denotes Using an in vitro competition assay (Figure 4A) utilizing purified activated GATA-3, importin-α, and activated GR, we demonstrated that activated GR significantly increased GR-importin-α association in the presence and absence of activated GATA-3 (Figure 4B).
T216 7765-7867 Sentence denotes This effect is not mutual, since activated GATA-3 did not block GR–importin-α association (Figure 4C).
T217 7868-8108 Sentence denotes These data also suggest that both activated GR and phospho-GATA-3 can directly associate with importin-α (Figure 4D) and that activated GR attenuates the phospho-GATA-3/importin-α interaction in a concentration-dependent manner (Figure 4E).
T218 8109-8245 Sentence denotes Together, this suggests that ligand-activated GR may compete with phospho-GATA-3 for importin-α and thereby limit GATA-3 nuclear import.
T219 8246-8357 Sentence denotes 10.1371/journal.pmed.1000076.g004 Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α.
T220 8358-9202 Sentence denotes (A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p<0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p<0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p<0.05 compared to GATA-3 isolated from unstimulated cells. # p<0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p<0.05, **p<0.01 between groups.
T221 9203-9331 Sentence denotes All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test.
T222 9334-9454 Sentence denotes Other possible interpretations of our results could include an effect of FP on GATA-3 nuclear export and/or degradation.
T223 9455-9582 Sentence denotes Leptomycin B, which inhibits nuclear export, did not affect the ability of FP to block GATA-3 nuclear localization (Figure 5A).
T224 9583-9702 Sentence denotes Additionally, FP had no effect on whole cell GATA-3 expression during the time course of these experiments (Figure 5B).
T225 9703-9889 Sentence denotes Nor did addition of FP subsequent to anti-CD3/CD28 nuclear translocation affect GATA-3 nuclear residency (Figure 5C), suggesting that activated GR does not enhance GATA-3 nuclear export.
T226 9890-10054 Sentence denotes Finally, the effect of FP on GATA-3 nuclear import was not nonspecific, since FP (10−8 M) had no effect on p65 nuclear translocation measured at 60 min (Figure 5D).
T227 10055-10160 Sentence denotes 10.1371/journal.pmed.1000076.g005 Figure 5 Fluticasone propionate does not affect GATA-3 nuclear export.
T228 10161-10679 Sentence denotes (A) Western blot analysis showing that the nuclear export inhibitor leptomycin B (2 nM) does not affect the ability of FP (10−8 M) to prevent anti-CD3/CD28–stimulated GATA-3 nuclear localization measured at 60 min. ***p<0.001 compared to unstimulated cells, ### p<0.001 compared to anti-CD3/CD28–stimulated cells. (B) Western blot analysis showing that FP (10−8 M) does not affect whole-cell GATA-3 degradation over 17 h. (C) GFP-tagged GATA-3 is overexpressed and cells stimulated (b–j) or not (a) with anti-CD3/CD28.
T229 10680-10943 Sentence denotes The effect of treating cells with FP (10−8 M, f–j) after 30 min stimulation with anti-CD3/CD28 is also shown. (D) FP (10−8 M) does not prevent anti-CD3/CD28–stimulated p65 nuclear translocation at 60 min after stimulation. **p<0.01 compared to unstimulated cells.
T230 10944-11042 Sentence denotes All results are representative of at least four independent experiments and are shown as mean±SEM.
T231 11043-11104 Sentence denotes Results were analysed by ANOVA followed by Newman-Keuls test.
T232 11106-11222 Sentence denotes The Inhibitory Effect of Corticosteroids on GATA-3 Nuclear Localization in Primary T Lymphocytes Ex Vivo and In Vivo
T233 11223-11581 Sentence denotes Treatment with FP ex vivo demonstrated a concentration-dependent decrease in the direct interaction between phospho-GATA-3 and importin-α in PBMCs from patients with asthma (Figure 6A and 6B), which was significantly inhibited at 10−12 M FP (p<0.001, ANOVA and Newman-Keuls test) and completely attenuated by 10−8 M FP (p<0.001, ANOVA and Newman-Keuls test).
T234 11582-11744 Sentence denotes 10.1371/journal.pmed.1000076.g006 Figure 6 Fluticasone propionate impairs GATA-3 interaction with importin-α and GATA-3 nuclear localization in vivo and ex vivo.
T235 11745-11939 Sentence denotes (A and B) Co-immunoprecipitation analysis of PBMCs from steroid-naïve asthma patients treated with FP in vitro demonstrated impaired interaction between GATA-3 and importin-α measured at 60 min.
T236 11940-12301 Sentence denotes Each bar represents the mean±SEM of at least three independent experiments; *** p<0.001 compared with control as determined by ANOVA/Newman-Keuls analysis. (C and D) Co-immunoprecipitation analyses of PBMCs from steroid-naïve asthma patients treated with inhaled FP (500 µg via a spacer) in vivo demonstrated decreased association between GATA-3 and importin-α.
T237 12302-12472 Sentence denotes The individual values for each treatment are presented graphically. (E) Representative Western blot showing that importin-α expression was unaffected by inhalation of FP.
T238 12473-12528 Sentence denotes Blot is representative of gels from three participants.
T239 12531-12709 Sentence denotes Our previous T cell line studies indicated that 10−12 M FP suppresses IL-4 and -5 gene expression and attenuated the interaction of GATA-3 with importin-α (see Figures 1D and 2).
T240 12710-12831 Sentence denotes This concentration is close to peak plasma levels obtained from asthmatic patients treated with inhaled FP (500 µg) [27].
T241 12832-12988 Sentence denotes Inhaled FP (500 µg) treatment of seven steroid-naive asthma patients significantly reduced GATA-3–importin-α interaction in vivo in a time-dependent manner.
T242 12989-13151 Sentence denotes This produced a >90% decrease in GATA-3–importin-α association at 2 h (median [95% CI], 13,494 [6,828–17,829] versus 879 [597–1,165]; p<0.05 Friedman's analysis).
T243 13152-13284 Sentence denotes However, this did not reach significance using Wilcoxon's post-test analysis (W = 6.00) probably due to low numbers of participants.
T244 13285-13382 Sentence denotes Similar results were observed when GATA-3–importin-α association was measured (Figure 6C and 6D).
T245 13383-13431 Sentence denotes The lower dose of FP (100 µg) was not effective.
T246 13432-13638 Sentence denotes The attenuated interaction of GATA-3 did not result from the defective recycling of importin-α, as a significant decrease in the abundance of importin-α in the cytoplasmic pool was not detected (Figure 6E).
T247 13639-13751 Sentence denotes We further examined whether inhaled FP could affect cellular localization of GATA-3 in peripheral blood T cells.
T248 13752-14102 Sentence denotes Treatment with inhaled FP (500 µg) for 2 h significantly increased GR nuclear translocation (Figure 7A) and concomitantly decreased the number of nuclear GATA-3 immunoreactive peripheral blood T cells (37%±4.2% versus 58.2%±4.95%, p = 0.016, W = 28.0, Wilcoxon's rank test) compared with placebo as measured by immunocytochemistry (Figure 7A and 7B).
T249 14103-14234 Sentence denotes This was confirmed by Western blotting, which also indicated that this effect was both time- and dose-dependent (Figure 7C and 7D).
T250 14235-14632 Sentence denotes Thus, inhaled FP (500 µg) induced significant loss in nuclear GATA-3 at 2 h (median [95% CI], 0.40 [0.27–0.53] versus 0.14 [0.11–0.19], p<0.05, W = 21.00, Wilcoxon's rank test) (Figure 7C) and cytoplasmic GATA-3 levels were enhanced by inhaled FP in a dose-dependent manner (median [95% CI], 0.0032 [0.0026–0.0039] versus 0.658 [0.592–0.720], p<0.05, W = −21.00, Wilcoxon's rank test) (Figure 7D).
T251 14633-14768 Sentence denotes In addition, FP (500 µg) inhibited p38 MAPK phosphorylation in primary T cells in vivo at 2 h in samples from two patients (Figure 7E).
T252 14769-14889 Sentence denotes 10.1371/journal.pmed.1000076.g007 Figure 7 Inhaled fluticasone propionate impairs GATA-3 nuclear localization in PBMCs.
T253 14890-15161 Sentence denotes (A) Representative immunocytochemistry of showing the effect of inhaled FP (500 µg) on GR and GATA-3 nuclear localisation. (B) Nuclear GATA-3 immunoreactivity in PBMCs from seven steroid-naïve asthma patients 2 h following inhaled FP treatment (100 or 500 µg via spacer).
T254 15162-15677 Sentence denotes The median and interquartile ranges for each treatment are presented as a box-and-whiskers plot (n = 7); * p<0.05 Wilcoxon's rank test compared with placebo. (C) Immunoblotting analyses of PBMCs demonstrated a time-dependent decrease in nuclear expression of GATA-3, and increased cytoplasmic GATA-3 expression after inhalation of FP. (D) Immunoblotting analyses of PBMCs demonstrated a dose-dependent decrease in nuclear expression of GATA-3, and increased cytoplasmic GATA-3 expression 2 h after inhalation of FP.
T255 15678-15812 Sentence denotes Histone H1 and MEK-1 immunoblotting confirmed equivalent total protein loading for the nuclear and cytoplasmic fractions respectively.
T256 15813-16174 Sentence denotes Quantification of the densitometry data in (C) and (D) is shown as a box-and-whiskers plot of results from n = 6 participants for which data were available. *p<0.05 compared to control. (E) Western blot analyses of PBMCs demonstrated a time-dependent decrease in dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK after inhalation of FP (500 µg).
T257 16175-16252 Sentence denotes The results shown in (E) are representative of samples from two participants.
T258 16255-16409 Sentence denotes Taken together, our data suggest that inhaled FP reduces nuclear localization of GATA-3 in vivo by acutely inhibiting phospho-GATA-3–importin association.
T259 16410-16596 Sentence denotes This effect may be direct, through competition for importin-α or associated molecules, or secondary to an effect on p38 MAPK-mediated GATA-3 phosphorylation via rapid induction of MKP-1.
T260 16597-16744 Sentence denotes The combination of these two interacting effects can result in complete suppression of GATA-3 nuclear import and thus Th2 cytokine gene expression.

ICD10

Id Subject Object Predicate Lexical cue
T19580 11815-11821 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T19581 12166-12172 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T19582 11815-11821 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T19583 12166-12172 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T12585 11389-11395 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T12586 12885-12891 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T12587 11389-11395 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T12588 12885-12891 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T20248 15083-15089 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T20249 15083-15089 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T8795 13-19 Regulation denotes Effect
T8796 13-19 Regulation denotes Effect
T8797 42-48 Protein denotes GATA-3
T8798 49-56 Entity denotes Nuclear
T8799 57-70 Localization denotes Translocation
T8800 75-79 Protein denotes IL-4
T8801 105-114 Regulation denotes effective
T8802 118-128 Negative_regulation denotes inhibiting
T8803 129-135 Protein denotes GATA-3
T8804 136-145 Regulation denotes regulated
T8805 146-150 Protein denotes IL-4
T8806 156-166 Gene_expression denotes expression
T8807 244-250 Regulation denotes affect true
T8808 265-275 Positive_regulation denotes stimulated
T8809 276-283 Entity denotes nuclear
T8810 284-290 Localization denotes import
T8811 294-300 Protein denotes GATA-3
T8812 342-350 Positive_regulation denotes resulted
T8813 374-381 Entity denotes nuclear
T8814 382-388 Protein denotes GATA-3
T8815 389-402 Localization denotes translocation
T8816 557-562 Protein denotes MEK-1
T8817 621-627 Positive_regulation denotes caused
T8818 621-627 Positive_regulation denotes caused
T8819 638-642 Negative_regulation denotes loss
T8820 646-653 Entity denotes nuclear
T8821 654-660 Protein denotes GATA-3
T8822 661-671 Localization denotes expression
T8823 676-687 Entity denotes cytoplasmic
T8824 688-697 Localization denotes retention
T8825 701-707 Protein denotes GATA-3
T8826 796-807 Regulation denotes This effect
T8827 796-807 Regulation denotes This effect
T8828 796-807 Regulation denotes This effect
T8829 836-845 Regulation denotes dependent
T8830 836-845 Regulation denotes dependent
T8831 836-845 Regulation denotes dependent
T8832 938-948 Regulation denotes associated
T8833 938-948 Regulation denotes associated
T8834 938-948 Regulation denotes associated
T8835 961-971 Negative_regulation denotes reductions
T8836 961-971 Negative_regulation denotes reductions
T8837 989-999 Positive_regulation denotes stimulated
T8838 989-999 Positive_regulation denotes stimulated
T8839 1000-1004 Protein denotes IL-4
T8840 1009-1013 Protein denotes IL-5
T8841 1014-1029 Transcription denotes mRNA expression
T8842 1014-1029 Transcription denotes mRNA expression
T8843 1048-1052 Negative_regulation denotes loss
T8844 1056-1062 Protein denotes GATA-3
T8845 1063-1070 Binding denotes binding
T8846 1085-1089 Protein denotes IL-5
T8847 1090-1098 Entity denotes promoter
T9360 2678-2680 Protein denotes GR
T9361 2695-2701 Protein denotes GATA-3
T9362 2702-2705 Binding denotes for
T9363 2782-2791 Positive_regulation denotes activated
T9364 2792-2794 Protein denotes GR
T9365 2806-2812 Protein denotes GATA-3
T9366 2813-2817 Positive_regulation denotes uses
T9367 2813-2817 Positive_regulation denotes uses
T9368 2837-2844 Entity denotes nuclear
T9369 2845-2851 Localization denotes import
T9370 2845-2851 Localization denotes import
T9371 2897-2899 Protein denotes GR
T9372 3010-3012 Protein denotes GR
T9373 3013-3020 Entity denotes nuclear
T9374 3021-3034 Localization denotes translocation
T9375 3172-3181 Negative_regulation denotes decreased
T9376 3186-3197 Binding denotes association
T9377 3206-3212 Protein denotes GATA-3
T9378 3228-3235 Positive_regulation denotes induced
T9379 3284-3293 Regulation denotes dependent
T9380 3333-3352 Protein denotes GFP-labelled GATA-3
T9381 3398-3404 Protein denotes GATA-3
T9382 3405-3412 Entity denotes nuclear
T9383 3413-3419 Localization denotes import
T9384 3420-3429 Positive_regulation denotes following
T9385 3471-3481 Negative_regulation denotes attenuated
T10991 5098-5103 Protein denotes MKP-1
T10992 5194-5203 Gene_expression denotes induction
T10993 5235-5240 Protein denotes MKP-1
T10994 5242-5260 Protein denotes MAPK phosphatase-1
T10995 5394-5403 Negative_regulation denotes decreased
T10996 5466-5481 Phosphorylation denotes phosphorylation
T10997 5500-5506 Binding denotes target
T10998 5507-5512 Protein denotes ATF-2
T10999 5634-5641 Negative_regulation denotes reduced
T11000 5642-5648 Protein denotes GATA-3
T11001 5649-5655 Entity denotes serine
T11002 5656-5671 Phosphorylation denotes phosphorylation
T11003 5672-5679 Positive_regulation denotes induced
T11004 5743-5752 Regulation denotes dependent
T11005 5773-5787 Negative_regulation denotes This reduction
T11006 5791-5797 Protein denotes GATA-3
T11007 5798-5813 Phosphorylation denotes phosphorylation
T11008 5892-5899 Positive_regulation denotes induced
T11009 5900-5905 Protein denotes MKP-1
T11010 5906-5910 Transcription denotes mRNA
T11011 5945-5954 Regulation denotes dependent
T11012 6038-6045 Regulation denotes effects
T11013 6038-6045 Regulation denotes effects
T11014 6038-6045 Regulation denotes effects
T11015 6055-6061 Protein denotes GATA-3
T11016 6062-6069 Entity denotes nuclear
T11017 6070-6076 Localization denotes import
T11018 6089-6100 Binding denotes association
T11019 6105-6109 Protein denotes IL-4
T11020 6110-6125 Transcription denotes mRNA expression
T11021 7523-7534 Negative_regulation denotes competition
T11022 7523-7534 Negative_regulation denotes competition
T11023 7572-7581 Positive_regulation denotes activated
T11024 7582-7588 Protein denotes GATA-3
T11025 7606-7615 Positive_regulation denotes activated
T11026 7616-7618 Protein denotes GR
T11027 7641-7650 Positive_regulation denotes activated
T11028 7651-7653 Protein denotes GR
T11029 7668-7677 Positive_regulation denotes increased
T11030 7678-7680 Protein denotes GR
T11031 7692-7703 Binding denotes association
T11032 7704-7734 Regulation denotes in the presence and absence of true
T11033 7735-7744 Positive_regulation denotes activated
T11034 7745-7751 Protein denotes GATA-3
T11035 7798-7807 Positive_regulation denotes activated
T11036 7808-7814 Protein denotes GATA-3
T11037 7823-7828 Negative_regulation denotes block true
T11038 7829-7831 Protein denotes GR
T11039 7843-7854 Binding denotes association
T11040 7902-7911 Positive_regulation denotes activated
T11041 7912-7914 Protein denotes GR
T11042 7927-7933 Protein denotes GATA-3
T11043 7947-7956 Binding denotes associate
T11044 7947-7956 Binding denotes associate
T11045 7994-8003 Positive_regulation denotes activated
T11046 8004-8006 Protein denotes GR
T11047 8007-8017 Negative_regulation denotes attenuates
T11048 8022-8029 Phosphorylation denotes phospho
T11049 8030-8036 Protein denotes GATA-3
T11050 8048-8059 Binding denotes interaction
T11051 8079-8088 Regulation denotes dependent
T11052 8145-8154 Positive_regulation denotes activated
T11053 8155-8157 Protein denotes GR
T11054 8162-8169 Negative_regulation denotes compete true
T11055 8183-8189 Protein denotes GATA-3
T11056 8190-8193 Binding denotes for
T11057 8217-8222 Negative_regulation denotes limit
T11058 8223-8229 Protein denotes GATA-3
T11059 8230-8237 Entity denotes nuclear
T11060 8238-8244 Localization denotes import
T11061 9397-9403 Regulation denotes effect
T11062 9397-9403 Regulation denotes effect
T11063 9413-9419 Protein denotes GATA-3
T11064 9420-9427 Entity denotes nuclear
T11065 9428-9434 Localization denotes export
T11066 9442-9453 Protein_catabolism denotes degradation
T11067 9508-9514 Regulation denotes affect true
T11068 9536-9541 Negative_regulation denotes block
T11069 9542-9548 Protein denotes GATA-3
T11070 9549-9556 Entity denotes nuclear
T11071 9557-9569 Localization denotes localization
T11072 9607-9613 Regulation denotes effect true
T11073 9628-9634 Protein denotes GATA-3
T11074 9635-9645 Gene_expression denotes expression
T11075 9776-9782 Regulation denotes affect true
T11076 9783-9789 Protein denotes GATA-3
T11077 9790-9797 Entity denotes nuclear
T11078 9798-9807 Localization denotes residency
T11079 9837-9846 Positive_regulation denotes activated
T11080 9847-9849 Protein denotes GR
T11081 9859-9866 Positive_regulation denotes enhance true
T11082 9867-9873 Protein denotes GATA-3
T11083 9874-9881 Entity denotes nuclear
T11084 9882-9888 Localization denotes export
T11085 9903-9909 Regulation denotes effect
T11086 9919-9925 Protein denotes GATA-3
T11087 9926-9933 Entity denotes nuclear
T11088 9934-9940 Localization denotes import
T11089 9987-9993 Regulation denotes effect true
T11090 9997-10000 Protein denotes p65
T11091 10001-10008 Entity denotes nuclear
T11092 10009-10022 Localization denotes translocation
T12731 11110-11120 Negative_regulation denotes Inhibitory
T12732 11150-11156 Protein denotes GATA-3
T12733 11157-11164 Entity denotes Nuclear
T12734 11165-11177 Localization denotes Localization
T12735 11278-11287 Regulation denotes dependent
T12736 11288-11296 Negative_regulation denotes decrease
T12737 11311-11322 Binding denotes interaction
T12738 11331-11338 Phosphorylation denotes phospho
T12739 11339-11345 Protein denotes GATA-3
T12740 11440-11449 Negative_regulation denotes inhibited
T12741 11518-11528 Negative_regulation denotes attenuated
T12742 12590-12600 Negative_regulation denotes suppresses
T12743 12590-12600 Negative_regulation denotes suppresses
T12744 12601-12605 Protein denotes IL-4
T12745 12610-12612 Protein denotes -5
T12746 12618-12628 Gene_expression denotes expression
T12747 12618-12628 Gene_expression denotes expression
T12748 12633-12643 Negative_regulation denotes attenuated
T12749 12648-12659 Binding denotes interaction
T12750 12663-12669 Protein denotes GATA-3
T12751 12915-12922 Negative_regulation denotes reduced
T12752 12923-12929 Protein denotes GATA-3
T12753 12941-12952 Binding denotes interaction
T12754 12971-12980 Regulation denotes dependent
T12755 12994-13002 Regulation denotes produced
T12756 13010-13018 Negative_regulation denotes decrease
T12757 13022-13028 Protein denotes GATA-3
T12758 13040-13051 Binding denotes association
T12759 13320-13326 Protein denotes GATA-3
T12760 13338-13349 Binding denotes association
T12761 13436-13446 Negative_regulation denotes attenuated
T12762 13447-13458 Binding denotes interaction
T12763 13462-13468 Protein denotes GATA-3
T12764 13684-13690 Regulation denotes affect true
T12765 13700-13712 Localization denotes localization
T12766 13716-13722 Protein denotes GATA-3
T12767 13809-13818 Positive_regulation denotes increased
T12768 13819-13821 Protein denotes GR
T12769 13822-13829 Entity denotes nuclear
T12770 13830-13843 Localization denotes translocation
T12771 13906-13912 Protein denotes GATA-3
T12772 14261-14268 Positive_regulation denotes induced
T12773 14281-14285 Localization denotes loss true
T12774 14289-14296 Entity denotes nuclear
T12775 14297-14303 Protein denotes GATA-3
T12776 14428-14439 Entity denotes cytoplasmic
T12777 14440-14446 Protein denotes GATA-3
T12778 14447-14453 Localization denotes levels
T12779 14459-14467 Positive_regulation denotes enhanced
T12780 14492-14501 Regulation denotes dependent
T12781 16304-16311 Negative_regulation denotes reduces
T12782 16312-16319 Entity denotes nuclear
T12783 16320-16332 Localization denotes localization
T12784 16336-16342 Protein denotes GATA-3
T12785 16362-16372 Negative_regulation denotes inhibiting
T12786 16381-16387 Protein denotes GATA-3
T12787 16397-16408 Binding denotes association
T12788 16535-16543 Positive_regulation denotes mediated
T12789 16544-16550 Protein denotes GATA-3
T12790 16551-16566 Phosphorylation denotes phosphorylation
T12791 16577-16586 Gene_expression denotes induction
T12792 16590-16595 Protein denotes MKP-1
T12793 16638-16645 Regulation denotes effects
T12794 16669-16680 Negative_regulation denotes suppression
T12795 16684-16690 Protein denotes GATA-3
T12796 16691-16698 Entity denotes nuclear
T12797 16699-16705 Localization denotes import
T16674 1227-1235 Negative_regulation denotes inhibits
T16675 1236-1242 Protein denotes GATA-3
T16676 1243-1250 Entity denotes nuclear
T16677 1251-1257 Localization denotes import
T16678 1314-1327 Localization denotes translocation
T16679 1331-1337 Protein denotes GATA-3
T16680 1364-1371 Entity denotes nucleus
T16681 1406-1411 Protein denotes MEK-1
T16682 1595-1602 Entity denotes nuclear
T16683 1603-1615 Localization denotes localization
T16684 1619-1625 Protein denotes GATA-3
T16685 1626-1633 Positive_regulation denotes induced
T16686 1822-1826 Protein denotes MEK1
T16687 2072-2080 Negative_regulation denotes inhibits
T16688 2072-2080 Negative_regulation denotes inhibits
T16689 2081-2085 Protein denotes IL-4
T16690 2090-2094 Protein denotes IL-5
T16691 2095-2110 Transcription denotes mRNA expression
T16692 2095-2110 Transcription denotes mRNA expression
T16693 2114-2117 Protein denotes CD3
T16694 2118-2122 Protein denotes CD28
T16695 2123-2135 Regulation denotes costimulated
T16696 2123-2135 Regulation denotes costimulated
T16697 2390-2397 Negative_regulation denotes reduces
T16698 2427-2437 Positive_regulation denotes stimulated
T16699 2438-2444 Protein denotes GATA-3
T16700 2448-2457 Binding denotes associate
T16701 2474-2478 Protein denotes IL-5
T16702 2479-2487 Entity denotes promoter
T17478 3595-3602 Negative_regulation denotes reduces
T17479 3595-3602 Negative_regulation denotes reduces
T17480 3603-3609 Protein denotes GATA-3
T17481 3610-3621 Binding denotes association
T17482 3642-3648 Protein denotes GATA-3
T17483 3649-3656 Entity denotes nuclear
T17484 3657-3663 Localization denotes import
T17485 3776-3785 Regulation denotes dependent
T17486 3786-3795 Positive_regulation denotes induction
T17487 3802-3811 Positive_regulation denotes activated
T17488 3812-3814 Protein denotes GR
T17489 3815-3826 Binding denotes interaction
T17490 3875-3877 Protein denotes GR
T17491 3878-3889 Binding denotes association
T17492 4199-4208 Regulation denotes dependent
T17493 4209-4218 Positive_regulation denotes induction
T17494 4225-4234 Positive_regulation denotes activated
T17495 4235-4237 Protein denotes GR
T17496 4238-4245 Entity denotes nuclear
T17497 4246-4259 Localization denotes translocation
T17498 4556-4565 Regulation denotes dependent
T17499 4566-4574 Negative_regulation denotes decrease
T17500 4578-4584 Protein denotes GATA-3
T17501 4596-4607 Binding denotes association
T17502 4846-4852 Protein denotes GATA-3
T17503 4857-4870 Gene_expression denotes overexpressed
T18198 6335-6345 Regulation denotes associated
T18199 6360-6375 Negative_regulation denotes down-regulation
T18200 6379-6385 Protein denotes GATA-3
T18201 6386-6392 Entity denotes serine
T18202 6393-6408 Phosphorylation denotes phosphorylation
T18203 6619-6625 Regulation denotes effect
T18204 6644-6659 Phosphorylation denotes phosphorylation
T18205 6663-6695 Protein denotes activated transcription factor 2
T18206 6697-6702 Protein denotes ATF-2
T18207 6807-6815 Negative_regulation denotes decrease
T18208 6848-6855 Positive_regulation denotes induced
T18209 6856-6862 Entity denotes serine
T18210 6863-6878 Phosphorylation denotes phosphorylation
T18211 6890-6896 Protein denotes GATA-3
T18212 7127-7134 Positive_regulation denotes induced
T18213 7135-7140 Protein denotes MKP-1
T18214 7165-7174 Regulation denotes dependent
T18215 7318-7325 Positive_regulation denotes induces
T18216 7326-7331 Protein denotes MKP-1
T18217 7347-7356 Regulation denotes dependent
T18606 8327-8334 Phosphorylation denotes phospho
T18607 8335-8341 Protein denotes GATA-3
T18608 8434-8436 Protein denotes GR
T18609 8480-8488 Positive_regulation denotes enhances
T18610 8489-8491 Protein denotes GR
T18611 8503-8510 Binding denotes binding
T18612 8560-8566 Protein denotes GATA-3
T18613 8592-8601 Positive_regulation denotes activated
T18614 8602-8604 Protein denotes GR
T18615 8610-8616 Protein denotes GATA-3
T18616 8671-8680 Negative_regulation denotes attenuate true
T18617 8681-8683 Protein denotes GR
T18618 8695-8706 Binding denotes association
T18619 8741-8750 Positive_regulation denotes Activated
T18620 8751-8753 Protein denotes GR
T18621 8754-8760 Negative_regulation denotes blocks
T18622 8785-8792 Phosphorylation denotes phospho
T18623 8793-8799 Protein denotes GATA-3
T18624 8845-8856 Binding denotes interacting
T18625 8935-8941 Protein denotes GATA-3
T18626 8997-9007 Positive_regulation denotes stimulated
T18627 9008-9014 Protein denotes GATA-3
T18628 9024-9031 Binding denotes binding
T18629 9051-9060 Positive_regulation denotes activated
T18630 9072-9084 Positive_regulation denotes unstimulated true
T18631 9089-9091 Protein denotes GR
T18632 9095-9106 Negative_regulation denotes attenuation
T18633 9110-9116 Protein denotes GATA-3
T18634 9128-9139 Binding denotes association
T18635 9158-9167 Regulation denotes dependent
T19230 10131-10137 Regulation denotes affect true
T19231 10138-10144 Protein denotes GATA-3
T19232 10153-10159 Localization denotes export
T19233 10258-10264 Regulation denotes affect true
T19234 10295-10302 Negative_regulation denotes prevent
T19235 10317-10327 Positive_regulation denotes stimulated
T19236 10328-10334 Protein denotes GATA-3
T19237 10335-10342 Entity denotes nuclear
T19238 10343-10355 Localization denotes localization
T20332 14844-14851 Negative_regulation denotes impairs
T20333 14852-14858 Protein denotes GATA-3
T20334 14859-14866 Entity denotes nuclear
T20335 14867-14879 Localization denotes localization
T20336 14977-14979 Protein denotes GR
T20337 14984-14990 Protein denotes GATA-3
T20338 14991-14998 Entity denotes nuclear
T20339 14999-15011 Localization denotes localisation
T20340 14999-15011 Localization denotes localisation
T20341 15025-15031 Protein denotes GATA-3
T20342 15377-15386 Regulation denotes dependent
T20343 15377-15386 Regulation denotes dependent
T20344 15387-15395 Negative_regulation denotes decrease
T20345 15399-15406 Entity denotes nuclear
T20346 15407-15417 Localization denotes expression
T20347 15421-15427 Protein denotes GATA-3
T20348 15433-15442 Positive_regulation denotes increased
T20349 15443-15454 Entity denotes cytoplasmic
T20350 15455-15461 Protein denotes GATA-3
T20351 15462-15472 Localization denotes expression
T20352 15564-15572 Negative_regulation denotes decrease
T20353 15576-15583 Entity denotes nuclear
T20354 15584-15594 Localization denotes expression
T20355 15598-15604 Protein denotes GATA-3
T20356 15620-15631 Entity denotes cytoplasmic
T20357 15632-15638 Protein denotes GATA-3
T20358 15639-15649 Localization denotes expression
T20359 15693-15698 Protein denotes MEK-1
T19239 10535-10541 Regulation denotes affect true
T19240 10553-10559 Protein denotes GATA-3
T19241 10560-10571 Protein_catabolism denotes degradation
T19242 10598-10604 Protein denotes GATA-3
T19243 10815-10822 Negative_regulation denotes prevent true
T19244 10837-10847 Positive_regulation denotes stimulated
T19245 10848-10851 Protein denotes p65
T19246 10852-10859 Entity denotes nuclear
T19247 10860-10873 Localization denotes translocation
T19629 11649-11656 Negative_regulation denotes impairs
T19630 11649-11656 Negative_regulation denotes impairs
T19631 11657-11663 Protein denotes GATA-3
T19632 11664-11675 Binding denotes interaction
T19633 11696-11702 Protein denotes GATA-3
T19634 11703-11710 Entity denotes nuclear
T19635 11711-11723 Localization denotes localization
T19636 11869-11877 Negative_regulation denotes impaired
T19637 11878-11889 Binding denotes interaction
T19638 11898-11904 Protein denotes GATA-3
T19639 12249-12258 Negative_regulation denotes decreased
T19640 12259-12270 Binding denotes association
T19641 12279-12285 Protein denotes GATA-3
R7591 T8797 T8799 themeOf GATA-3,Translocation
R7592 T8798 T8799 locationOf Nuclear,Translocation
R7593 T8799 T8795 themeOf Translocation,Effect
R7594 T8800 T8796 themeOf IL-4,Effect
R7595 T8802 T8801 themeOf inhibiting,effective
R7596 T8803 T8804 causeOf GATA-3,regulated
R7597 T8804 T8802 themeOf regulated,inhibiting
R7598 T8805 T8806 themeOf IL-4,expression
R7599 T8806 T8804 themeOf expression,regulated
R7600 T8808 T8807 themeOf stimulated,affect
R7601 T8809 T8810 locationOf nuclear,import
R7602 T8810 T8808 themeOf import,stimulated
R7603 T8811 T8810 themeOf GATA-3,import
R7604 T8813 T8815 locationOf nuclear,translocation
R7605 T8814 T8815 themeOf GATA-3,translocation
R7606 T8815 T8812 themeOf translocation,resulted
R7607 T8819 T8818 themeOf loss,caused
R7608 T8820 T8822 locationOf nuclear,expression
R7609 T8821 T8822 themeOf GATA-3,expression
R7610 T8822 T8819 themeOf expression,loss
R7611 T8823 T8824 locationOf cytoplasmic,retention
R7612 T8824 T8817 themeOf retention,caused
R7613 T8825 T8824 themeOf GATA-3,retention
R7614 T8826 T8831 themeOf This effect,dependent
R7615 T8827 T8830 themeOf This effect,dependent
R7616 T8828 T8829 themeOf This effect,dependent
R7617 T8832 T8827 themeOf associated,This effect
R7618 T8833 T8828 themeOf associated,This effect
R7619 T8834 T8826 themeOf associated,This effect
R7620 T8835 T8834 themeOf reductions,associated
R7621 T8836 T8832 themeOf reductions,associated
R7622 T8837 T8835 themeOf stimulated,reductions
R7623 T8838 T8836 themeOf stimulated,reductions
R7624 T8839 T8842 themeOf IL-4,mRNA expression
R7625 T8840 T8841 themeOf IL-5,mRNA expression
R7626 T8841 T8838 themeOf mRNA expression,stimulated
R7627 T8842 T8837 themeOf mRNA expression,stimulated
R7628 T8843 T8833 themeOf loss,associated
R7629 T8844 T8845 themeOf GATA-3,binding
R7630 T8845 T8843 themeOf binding,loss
R7631 T8847 T8845 themeOf promoter,binding
R7632 T8847 T8846 partOf promoter,IL-5
R8068 T9373 T9374 locationOf nuclear,translocation
R8069 T9375 T9379 themeOf decreased,dependent
R8070 T9376 T9375 themeOf association,decreased
R8071 T9376 T9378 themeOf association,induced
R8072 T9377 T9376 themeOf GATA-3,association
R8073 T9381 T9383 themeOf GATA-3,import
R8074 T9382 T9383 locationOf nuclear,import
R8075 T9383 T9384 themeOf import,following
R8076 T9383 T9385 themeOf import,attenuated
R9420 T10993 T10992 themeOf MKP-1,induction
R9421 T10994 T10993 equivalentTo MAPK phosphatase-1,MKP-1
R9422 T10996 T10995 themeOf phosphorylation,decreased
R9423 T10998 T10996 themeOf ATF-2,phosphorylation
R9424 T10998 T10997 themeOf ATF-2,target
R9425 T10999 T11004 themeOf reduced,dependent
R9426 T11001 T11002 themeOf serine,phosphorylation
R9427 T11001 T11000 partOf serine,GATA-3
R9428 T11002 T10999 themeOf phosphorylation,reduced
R9429 T11002 T11003 themeOf phosphorylation,induced
R9430 T11006 T11007 themeOf GATA-3,phosphorylation
R9431 T11007 T11005 themeOf phosphorylation,This reduction
R9432 T11008 T11011 themeOf induced,dependent
R9433 T11009 T11010 themeOf MKP-1,mRNA
R9434 T11010 T11008 themeOf mRNA,induced
R9435 T11015 T11017 themeOf GATA-3,import
R9436 T11015 T11018 themeOf GATA-3,association
R9437 T11016 T11017 locationOf nuclear,import
R9438 T11017 T11014 themeOf import,effects
R9439 T11018 T11012 themeOf association,effects
R9440 T11019 T11020 themeOf IL-4,mRNA expression
R9441 T11020 T11013 themeOf mRNA expression,effects
R9442 T11024 T11021 themeOf GATA-3,competition
R9443 T11024 T11023 themeOf GATA-3,activated
R9444 T11026 T11022 themeOf GR,competition
R9445 T11026 T11025 themeOf GR,activated
R9446 T11028 T11027 themeOf GR,activated
R9447 T11028 T11029 causeOf GR,increased
R9448 T11029 T11032 themeOf increased,in the presence and absence of
R9449 T11030 T11031 themeOf GR,association
R9450 T11031 T11029 themeOf association,increased
R9451 T11033 T11032 causeOf activated,in the presence and absence of
R9452 T11034 T11033 themeOf GATA-3,activated
R9453 T11036 T11035 themeOf GATA-3,activated
R9454 T11036 T11037 causeOf GATA-3,block
R9455 T11038 T11039 themeOf GR,association
R9456 T11039 T11037 themeOf association,block
R9457 T11041 T11040 themeOf GR,activated
R9458 T11041 T11043 themeOf GR,associate
R9459 T11042 T11044 themeOf GATA-3,associate
R9460 T11046 T11045 themeOf GR,activated
R9461 T11046 T11047 causeOf GR,attenuates
R9462 T11047 T11051 themeOf attenuates,dependent
R9463 T11049 T11050 themeOf GATA-3,interaction
R9464 T11049 T11048 themeOf GATA-3,phospho
R9465 T11050 T11047 themeOf interaction,attenuates
R9466 T11053 T11052 themeOf GR,activated
R9467 T11053 T11054 causeOf GR,compete
R9468 T11054 T11057 causeOf compete,limit
R9469 T11055 T11056 themeOf GATA-3,for
R9470 T11056 T11054 themeOf for,compete
R9471 T11058 T11060 themeOf GATA-3,import
R9472 T11059 T11060 locationOf nuclear,import
R9473 T11060 T11057 themeOf import,limit
R9474 T11063 T11065 themeOf GATA-3,export
R9475 T11063 T11066 themeOf GATA-3,degradation
R9476 T11064 T11065 locationOf nuclear,export
R9477 T11065 T11061 themeOf export,effect
R9478 T11066 T11062 themeOf degradation,effect
R9479 T11068 T11067 themeOf block,affect
R9480 T11069 T11071 themeOf GATA-3,localization
R9481 T11070 T11071 locationOf nuclear,localization
R9482 T11071 T11068 themeOf localization,block
R9483 T11073 T11074 themeOf GATA-3,expression
R9484 T11074 T11072 themeOf expression,effect
R9485 T11076 T11078 themeOf GATA-3,residency
R9486 T11077 T11078 locationOf nuclear,residency
R9487 T11078 T11075 themeOf residency,affect
R9488 T11080 T11079 themeOf GR,activated
R9489 T11080 T11081 causeOf GR,enhance
R9490 T11082 T11084 themeOf GATA-3,export
R9491 T11083 T11084 locationOf nuclear,export
R9492 T11084 T11081 themeOf export,enhance
R9493 T11086 T11088 themeOf GATA-3,import
R9494 T11087 T11088 locationOf nuclear,import
R9495 T11088 T11085 themeOf import,effect
R9496 T11090 T11092 themeOf p65,translocation
R9497 T11091 T11092 locationOf nuclear,translocation
R9498 T11092 T11089 themeOf translocation,effect
R10967 T12732 T12734 themeOf GATA-3,Localization
R10968 T12733 T12734 locationOf Nuclear,Localization
R10969 T12734 T12731 themeOf Localization,Inhibitory
R10970 T12736 T12735 themeOf decrease,dependent
R10971 T12737 T12736 themeOf interaction,decrease
R10972 T12737 T12740 themeOf interaction,inhibited
R10973 T12737 T12741 themeOf interaction,attenuated
R10974 T12739 T12737 themeOf GATA-3,interaction
R10975 T12739 T12738 themeOf GATA-3,phospho
R10976 T12744 T12747 themeOf IL-4,expression
R10977 T12745 T12746 themeOf -5,expression
R10978 T12746 T12742 themeOf expression,suppresses
R10979 T12747 T12743 themeOf expression,suppresses
R10980 T12749 T12748 themeOf interaction,attenuated
R10981 T12750 T12749 themeOf GATA-3,interaction
R10982 T12751 T12754 themeOf reduced,dependent
R10983 T12752 T12753 themeOf GATA-3,interaction
R10984 T12753 T12751 themeOf interaction,reduced
R10985 T12756 T12755 themeOf decrease,produced
R10986 T12757 T12758 themeOf GATA-3,association
R10987 T12758 T12756 themeOf association,decrease
R10988 T12759 T12760 themeOf GATA-3,association
R10989 T12762 T12761 themeOf interaction,attenuated
R10990 T12763 T12762 themeOf GATA-3,interaction
R10991 T12765 T12764 themeOf localization,affect
R10992 T12766 T12765 themeOf GATA-3,localization
R10993 T12768 T12770 themeOf GR,translocation
R10994 T12769 T12770 locationOf nuclear,translocation
R10995 T12770 T12767 themeOf translocation,increased
R10996 T12773 T12772 themeOf loss,induced
R10997 T12774 T12773 locationOf nuclear,loss
R10998 T12775 T12773 themeOf GATA-3,loss
R10999 T12776 T12778 locationOf cytoplasmic,levels
R11000 T12777 T12778 themeOf GATA-3,levels
R11001 T12778 T12779 themeOf levels,enhanced
R11002 T12779 T12780 themeOf enhanced,dependent
R11003 T12782 T12783 locationOf nuclear,localization
R11004 T12783 T12781 themeOf localization,reduces
R11005 T12784 T12783 themeOf GATA-3,localization
R11006 T12785 T12781 causeOf inhibiting,reduces
R11007 T12786 T12787 themeOf GATA-3,association
R11008 T12787 T12785 themeOf association,inhibiting
R11009 T12789 T12790 themeOf GATA-3,phosphorylation
R11010 T12790 T12788 themeOf phosphorylation,mediated
R11011 T12792 T12791 themeOf MKP-1,induction
R11012 T12794 T12793 themeOf suppression,effects
R11013 T12795 T12797 themeOf GATA-3,import
R11014 T12796 T12797 locationOf nuclear,import
R11015 T12797 T12794 themeOf import,suppression
R14316 T16675 T16677 themeOf GATA-3,import
R14317 T16676 T16677 locationOf nuclear,import
R14318 T16677 T16674 themeOf import,inhibits
R14319 T16679 T16678 themeOf GATA-3,translocation
R14320 T16680 T16678 locationOf nucleus,translocation
R14321 T16682 T16683 locationOf nuclear,localization
R14322 T16683 T16685 themeOf localization,induced
R14323 T16684 T16683 themeOf GATA-3,localization
R14324 T16689 T16691 themeOf IL-4,mRNA expression
R14325 T16690 T16692 themeOf IL-5,mRNA expression
R14326 T16691 T16688 themeOf mRNA expression,inhibits
R14327 T16692 T16687 themeOf mRNA expression,inhibits
R14328 T16693 T16696 themeOf CD3,costimulated
R14329 T16694 T16695 themeOf CD28,costimulated
R14330 T16699 T16700 themeOf GATA-3,associate
R14331 T16699 T16698 themeOf GATA-3,stimulated
R14332 T16700 T16697 themeOf associate,reduces
R14333 T16702 T16700 themeOf promoter,associate
R14334 T16702 T16701 partOf promoter,IL-5
R15003 T17480 T17481 themeOf GATA-3,association
R15004 T17481 T17478 themeOf association,reduces
R15005 T17482 T17484 themeOf GATA-3,import
R15006 T17483 T17484 locationOf nuclear,import
R15007 T17484 T17479 themeOf import,reduces
R15008 T17486 T17485 themeOf induction,dependent
R15009 T17488 T17489 themeOf GR,interaction
R15010 T17488 T17487 themeOf GR,activated
R15011 T17489 T17486 themeOf interaction,induction
R15012 T17490 T17491 themeOf GR,association
R15013 T17493 T17492 themeOf induction,dependent
R15014 T17495 T17497 themeOf GR,translocation
R15015 T17495 T17494 themeOf GR,activated
R15016 T17496 T17497 locationOf nuclear,translocation
R15017 T17497 T17493 themeOf translocation,induction
R15018 T17499 T17498 themeOf decrease,dependent
R15019 T17500 T17501 themeOf GATA-3,association
R15020 T17501 T17499 themeOf association,decrease
R15021 T17502 T17503 themeOf GATA-3,overexpressed
R15590 T18199 T18198 themeOf down-regulation,associated
R15591 T18201 T18202 themeOf serine,phosphorylation
R15592 T18201 T18200 partOf serine,GATA-3
R15593 T18202 T18199 themeOf phosphorylation,down-regulation
R15594 T18204 T18203 themeOf phosphorylation,effect
R15595 T18205 T18204 themeOf activated transcription factor 2,phosphorylation
R15596 T18206 T18205 equivalentTo ATF-2,activated transcription factor 2
R15597 T18209 T18211 partOf serine,GATA-3
R15598 T18209 T18210 themeOf serine,phosphorylation
R15599 T18210 T18208 themeOf phosphorylation,induced
R15600 T18210 T18207 themeOf phosphorylation,decrease
R15601 T18212 T18214 themeOf induced,dependent
R15602 T18213 T18212 themeOf MKP-1,induced
R15603 T18215 T18217 themeOf induces,dependent
R15604 T18216 T18215 themeOf MKP-1,induces
R15907 T18607 T18606 themeOf GATA-3,phospho
R15908 T18608 T18609 causeOf GR,enhances
R15909 T18610 T18611 themeOf GR,binding
R15910 T18611 T18609 themeOf binding,enhances
R15911 T18614 T18613 themeOf GR,activated
R15912 T18615 T18616 causeOf GATA-3,attenuate
R15913 T18617 T18618 themeOf GR,association
R15914 T18618 T18616 themeOf association,attenuate
R15915 T18620 T18621 causeOf GR,blocks
R15916 T18620 T18619 themeOf GR,Activated
R15917 T18623 T18624 themeOf GATA-3,interacting
R15918 T18623 T18622 themeOf GATA-3,phospho
R15919 T18624 T18621 themeOf interacting,blocks
R15920 T18627 T18628 themeOf GATA-3,binding
R15921 T18628 T18626 themeOf binding,stimulated
R15922 T18631 T18629 themeOf GR,activated
R15923 T18631 T18630 themeOf GR,unstimulated
R15924 T18631 T18632 causeOf GR,attenuation
R15925 T18632 T18635 themeOf attenuation,dependent
R15926 T18633 T18634 themeOf GATA-3,association
R15927 T18634 T18632 themeOf association,attenuation
R16418 T19231 T19232 themeOf GATA-3,export
R16419 T19232 T19230 themeOf export,affect
R16420 T19234 T19233 themeOf prevent,affect
R16421 T19236 T19238 themeOf GATA-3,localization
R16422 T19237 T19238 locationOf nuclear,localization
R16423 T19238 T19234 themeOf localization,prevent
R16424 T19238 T19235 themeOf localization,stimulated
R16425 T19240 T19241 themeOf GATA-3,degradation
R16426 T19241 T19239 themeOf degradation,affect
R16427 T19245 T19247 themeOf p65,translocation
R16428 T19246 T19247 locationOf nuclear,translocation
R16429 T19247 T19243 themeOf translocation,prevent
R16430 T19247 T19244 themeOf translocation,stimulated
R16769 T19631 T19632 themeOf GATA-3,interaction
R16770 T19632 T19629 themeOf interaction,impairs
R16771 T19633 T19635 themeOf GATA-3,localization
R16772 T19634 T19635 locationOf nuclear,localization
R16773 T19635 T19630 themeOf localization,impairs
R16774 T19637 T19636 themeOf interaction,impaired
R16775 T19638 T19637 themeOf GATA-3,interaction
R16776 T19640 T19639 themeOf association,decreased
R16777 T19641 T19640 themeOf GATA-3,association
R17384 T20333 T20335 themeOf GATA-3,localization
R17385 T20334 T20335 locationOf nuclear,localization
R17386 T20335 T20332 themeOf localization,impairs
R17387 T20336 T20339 themeOf GR,localisation
R17388 T20337 T20340 themeOf GATA-3,localisation
R17389 T20338 T20339 locationOf nuclear,localisation
R17390 T20338 T20340 locationOf nuclear,localisation
R17391 T20344 T20342 themeOf decrease,dependent
R17392 T20345 T20346 locationOf nuclear,expression
R17393 T20346 T20344 themeOf expression,decrease
R17394 T20347 T20346 themeOf GATA-3,expression
R17395 T20348 T20343 themeOf increased,dependent
R17396 T20349 T20351 locationOf cytoplasmic,expression
R17397 T20350 T20351 themeOf GATA-3,expression
R17398 T20351 T20348 themeOf expression,increased
R17399 T20353 T20354 locationOf nuclear,expression
R17400 T20354 T20352 themeOf expression,decrease
R17401 T20355 T20354 themeOf GATA-3,expression
R17402 T20356 T20358 locationOf cytoplasmic,expression
R17403 T20357 T20358 themeOf GATA-3,expression
R8059 T9361 T9362 themeOf GATA-3,for
R8060 T9364 T9363 themeOf GR,activated
R8061 T9364 T9370 themeOf GR,import
R8062 T9365 T9369 themeOf GATA-3,import
R8063 T9368 T9370 locationOf nuclear,import
R8064 T9368 T9369 locationOf nuclear,import
R8065 T9369 T9366 themeOf import,uses
R8066 T9370 T9367 themeOf import,uses
R8067 T9372 T9374 themeOf GR,translocation

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T8773 42-70 Protein denotes GATA-3 Nuclear Translocation
T8774 75-84 Protein denotes IL-4 mRNA
T8775 13-19 Regulation denotes Effect
T8776 13-19 Regulation denotes Effect
T8777 129-155 Protein denotes GATA-3-regulated IL-4 gene
T8778 156-166 Gene_expression denotes expression
T8779 118-128 Negative_regulation denotes inhibiting
T8780 251-259 Protein denotes anti-CD3
T8781 260-264 Protein denotes CD28
T8782 294-300 Protein denotes GATA-3
T8783 276-283 Entity denotes nuclear
T8784 284-290 Localization denotes import
T8785 284-290 Localization denotes import
T8786 244-250 Regulation denotes affect
T8787 244-250 Regulation denotes affect
T8788 333-336 Protein denotes CD3
T8789 337-341 Protein denotes CD28
T8790 542-552 Protein denotes histone H1
T8791 557-562 Protein denotes MEK-1
T8792 701-707 Protein denotes GATA-3
T8793 688-697 Localization denotes retention
T8794 638-642 Negative_regulation denotes loss
T8848 980-983 Protein denotes CD3
T8849 984-988 Protein denotes CD28
T8850 1000-1004 Protein denotes IL-4
T8851 1009-1018 Protein denotes IL-5 mRNA
T8852 1056-1062 Protein denotes GATA-3
T8853 1085-1098 Protein denotes IL-5 promoter
T8854 1019-1029 Gene_expression denotes expression
T8855 1019-1029 Gene_expression denotes expression
T8856 1048-1052 Negative_regulation denotes loss
T8857 1063-1070 Binding denotes binding
T8858 1063-1070 Binding denotes binding
T8859 961-971 Negative_regulation denotes reductions
T8860 961-971 Negative_regulation denotes reductions
T8861 989-999 Positive_regulation denotes stimulated
T8862 989-999 Positive_regulation denotes stimulated
T8863 1048-1052 Negative_regulation denotes loss
T8864 1048-1052 Negative_regulation denotes loss
T9334 2678-2680 Protein denotes GR
T9335 2695-2701 Protein denotes GATA-3
T9336 2706-2716 Protein denotes Importin-α
T9337 2661-2677 Positive_regulation denotes Ligand-Activated
T9338 2792-2794 Protein denotes GR
T9339 2806-2812 Protein denotes GATA-3
T9340 2818-2828 Protein denotes importin-α
T9341 2775-2791 Positive_regulation denotes ligand-activated
T9342 2775-2791 Positive_regulation denotes ligand-activated
T9343 2837-2844 Entity denotes nuclear
T9344 2845-2851 Localization denotes import
T9345 2897-2899 Protein denotes GR
T9346 2904-2914 Protein denotes importin-α
T9347 2877-2888 Binding denotes interaction
T9348 3010-3012 Protein denotes GR
T9349 3013-3020 Entity denotes nuclear
T9350 3021-3034 Localization denotes translocation
T9351 3206-3212 Protein denotes GATA-3
T9352 3217-3227 Protein denotes importin-α
T9353 3244-3247 Protein denotes CD3
T9354 3248-3252 Protein denotes CD28
T9355 3186-3197 Binding denotes association
T9356 3172-3181 Negative_regulation denotes decreased
T9357 3346-3352 Protein denotes GATA-3
T9358 3435-3438 Protein denotes CD3
T9359 3439-3443 Protein denotes CD28
T10943 5857-5859 Protein denotes FP
T10944 5798-5813 Phosphorylation denotes phosphorylation
T10945 5778-5787 Negative_regulation denotes reduction
T10946 5875-5877 Protein denotes FP
T10947 5900-5910 Protein denotes MKP-1 mRNA
T10948 5892-5899 Positive_regulation denotes induced
T10949 6105-6114 Protein denotes IL-4 mRNA
T10950 6115-6125 Gene_expression denotes expression
T10951 6038-6045 Regulation denotes effects
T10952 7582-7588 Protein denotes GATA-3
T10953 7590-7600 Protein denotes importin-α
T10954 7616-7618 Protein denotes GR
T10955 7651-7653 Protein denotes GR
T10956 7678-7680 Protein denotes GR
T10957 7572-7581 Positive_regulation denotes activated
T10958 7572-7581 Positive_regulation denotes activated
T10959 7606-7615 Positive_regulation denotes activated
T10960 7641-7650 Positive_regulation denotes activated
T10961 7808-7814 Protein denotes GATA-3
T10962 7829-7831 Protein denotes GR
T10963 7798-7807 Positive_regulation denotes activated
T10964 7912-7914 Protein denotes GR
T10965 8004-8006 Protein denotes GR
T10966 7902-7911 Positive_regulation denotes activated
T10967 7947-7956 Binding denotes associate
T10968 7994-8003 Positive_regulation denotes activated
T10969 8155-8157 Protein denotes GR
T10970 8138-8154 Positive_regulation denotes ligand-activated
T10971 9530-9532 Protein denotes FP
T10972 9508-9514 Regulation denotes affect
T10973 9549-9556 Entity denotes nuclear
T10974 9597-9599 Protein denotes FP
T10975 9635-9645 Gene_expression denotes expression
T10976 9607-9613 Regulation denotes effect
T10977 9723-9725 Protein denotes FP
T10978 9745-9748 Protein denotes CD3
T10979 9749-9753 Protein denotes CD28
T10980 9847-9849 Protein denotes GR
T10981 9754-9761 Entity denotes nuclear
T10982 9762-9775 Localization denotes translocation
T10983 9762-9775 Localization denotes translocation
T10984 9762-9775 Localization denotes translocation
T10985 9837-9846 Positive_regulation denotes activated
T10986 9997-10000 Protein denotes p65
T10987 9926-9933 Entity denotes nuclear
T10988 10001-10008 Entity denotes nuclear
T10989 10009-10022 Localization denotes translocation
T10990 9987-9993 Regulation denotes effect
T12798 11331-11345 Protein denotes phospho-GATA-3
T12799 11350-11360 Protein denotes importin-α
T12800 11311-11322 Binding denotes interaction
T12801 11288-11296 Negative_regulation denotes decrease
T12802 12585-12589 Protein denotes M FP
T12803 12601-12605 Protein denotes IL-4
T12804 12663-12669 Protein denotes GATA-3
T12805 12675-12685 Protein denotes importin-α
T12806 12618-12628 Gene_expression denotes expression
T12807 12648-12659 Binding denotes interaction
T12808 12590-12600 Negative_regulation denotes suppresses
T12809 12633-12643 Negative_regulation denotes attenuated
T12810 12923-12938 Protein denotes GATA-3–importin
T12811 12939-12940 Protein denotes α
T12812 12941-12952 Binding denotes interaction
T12813 12915-12922 Negative_regulation denotes reduced
T12814 13022-13037 Protein denotes GATA-3–importin
T12815 13462-13468 Protein denotes GATA-3
T12816 13516-13526 Protein denotes importin-α
T12817 13574-13584 Protein denotes importin-α
T12818 13447-13458 Binding denotes interaction
T12819 13561-13570 Localization denotes abundance
T12820 13545-13553 Negative_regulation denotes decrease
T12821 13716-13722 Protein denotes GATA-3
T12822 13691-13699 Entity denotes cellular
T12823 13700-13712 Localization denotes localization
T12824 13819-13821 Protein denotes GR
T12825 13822-13829 Entity denotes nuclear
T12826 13830-13843 Localization denotes translocation
T12827 13809-13818 Positive_regulation denotes increased
T12828 14428-14446 Protein denotes cytoplasmic GATA-3
T12829 14479-14481 Protein denotes FP
T12830 14289-14296 Entity denotes nuclear
T12831 14459-14467 Positive_regulation denotes enhanced
T12832 14668-14676 Protein denotes p38 MAPK
T12833 14677-14692 Phosphorylation denotes phosphorylation
T12834 14658-14667 Negative_regulation denotes inhibited
T12835 16336-16342 Protein denotes GATA-3
T12836 16312-16319 Entity denotes nuclear
T12837 16320-16332 Localization denotes localization
T12838 16304-16311 Negative_regulation denotes reduces
T12839 16461-16471 Protein denotes importin-α
T12840 16526-16529 Protein denotes p38
T12841 16590-16595 Protein denotes MKP-1
T12842 16445-16456 Binding denotes competition
T12843 16551-16566 Phosphorylation denotes phosphorylation
T12844 16577-16586 Positive_regulation denotes induction
T16703 1268-1271 Protein denotes CD3
T16704 1272-1276 Protein denotes CD28
T16705 1331-1337 Protein denotes GATA-3
T16706 1364-1371 Entity denotes nucleus
T16707 1314-1327 Localization denotes translocation
T16708 1391-1401 Protein denotes Histone H1
T16709 1406-1411 Protein denotes MEK-1
T16710 1619-1625 Protein denotes GATA-3
T16711 1637-1645 Protein denotes anti-CD3
T16712 1646-1650 Protein denotes CD28
T16713 1595-1602 Entity denotes nuclear
T16714 1603-1615 Localization denotes localization
T16715 1626-1633 Positive_regulation denotes induced
T16716 1586-1594 Negative_regulation denotes impaired
T16717 1822-1826 Protein denotes MEK1
T16718 1831-1841 Protein denotes histone H1
T16719 2069-2071 Protein denotes FP
T16720 2081-2085 Protein denotes IL-4
T16721 2090-2099 Protein denotes IL-5 mRNA
T16722 2114-2117 Protein denotes CD3
T16723 2118-2122 Protein denotes CD28
T16724 2100-2110 Gene_expression denotes expression
T16725 2100-2110 Gene_expression denotes expression
T16726 2072-2080 Negative_regulation denotes inhibits
T16727 2072-2080 Negative_regulation denotes inhibits
T16728 2143-2148 Protein denotes GAPDH
T16729 2354-2357 Protein denotes CD3
T16730 2358-2362 Protein denotes CD28
T16731 2418-2421 Protein denotes CD3
T16732 2422-2426 Protein denotes CD28
T16733 2438-2444 Protein denotes GATA-3
T16734 2474-2494 Protein denotes IL-5 promoter 60 min
T16735 2427-2437 Positive_regulation denotes stimulated
T16736 2448-2457 Binding denotes associate
T16737 2390-2397 Negative_regulation denotes reduces
T16738 2618-2623 Protein denotes ANOVA
T17504 3603-3609 Protein denotes GATA-3
T17505 3627-3637 Protein denotes importin-α
T17506 3642-3648 Protein denotes GATA-3
T17507 3610-3621 Binding denotes association
T17508 3649-3656 Entity denotes nuclear
T17509 3657-3663 Localization denotes import
T17510 3657-3663 Localization denotes import
T17511 3595-3602 Negative_regulation denotes reduces
T17512 3799-3801 Protein denotes FP
T17513 3812-3814 Protein denotes GR
T17514 3832-3842 Protein denotes importin-α
T17515 3844-3849 Protein denotes Imp-α
T17516 3815-3826 Binding denotes interaction
T17517 3815-3826 Binding denotes interaction
T17518 3815-3826 Binding denotes interaction
T17519 3802-3811 Positive_regulation denotes activated
T17520 3802-3811 Positive_regulation denotes activated
T17521 3802-3811 Positive_regulation denotes activated
T17522 3786-3795 Positive_regulation denotes induction
T17523 3786-3795 Positive_regulation denotes induction
T17524 3786-3795 Positive_regulation denotes induction
T17525 3875-3877 Protein denotes GR
T17526 3895-3903 Protein denotes importin
T17527 3878-3889 Binding denotes association
T17528 3863-3870 Regulation denotes control
T17529 4222-4224 Protein denotes FP
T17530 4235-4237 Protein denotes GR
T17531 4238-4245 Entity denotes nuclear
T17532 4246-4259 Localization denotes translocation
T17533 4225-4234 Positive_regulation denotes activated
T17534 4209-4218 Positive_regulation denotes induction
T17535 4491-4493 Protein denotes FP
T17536 4498-4506 Protein denotes anti-CD3
T17537 4507-4511 Protein denotes CD28
T17538 4578-4593 Protein denotes GATA-3–importin
T17539 4803-4807 Protein denotes αCD3
T17540 4808-4812 Protein denotes CD28
T17541 4846-4852 Protein denotes GATA-3
T17542 4931-4934 Protein denotes CD3
T17543 4935-4939 Protein denotes CD28
T17544 4857-4870 Gene_expression denotes overexpressed
T17545 4857-4870 Positive_regulation denotes overexpressed
T17546 5045-5050 Protein denotes ANOVA
T18168 6286-6300 Protein denotes p38 MAP kinase
T18169 6379-6385 Protein denotes GATA-3
T18170 6272-6282 Negative_regulation denotes inhibition
T18171 6301-6316 Phosphorylation denotes phosphorylation
T18172 6386-6392 Entity denotes serine
T18173 6393-6408 Phosphorylation denotes phosphorylation
T18174 6272-6282 Negative_regulation denotes inhibition
T18175 6360-6375 Negative_regulation denotes down-regulation
T18176 6542-6550 Protein denotes p38 MAPK
T18177 6554-6562 Protein denotes anti-CD3
T18178 6563-6567 Protein denotes CD28
T18179 6525-6537 Entity denotes tyrosine-182
T18180 6490-6505 Phosphorylation denotes phosphorylation
T18181 6477-6484 Negative_regulation denotes reduced
T18182 6718-6726 Protein denotes p38 MAPK
T18183 6644-6659 Phosphorylation denotes phosphorylation
T18184 6766-6774 Protein denotes p38 MAPK
T18185 6819-6827 Protein denotes anti-CD3
T18186 6828-6832 Protein denotes CD28
T18187 6890-6896 Protein denotes GATA-3
T18188 6752-6762 Negative_regulation denotes inhibition
T18189 6856-6862 Entity denotes serine
T18190 6880-6885 Entity denotes P-Ser
T18191 4803-4807 Protein denotes αCD3
T18192 4808-4812 Protein denotes CD28
T18636 8327-8334 Protein denotes phospho
T18637 8335-8341 Protein denotes GATA-3
T18638 8346-8356 Protein denotes importin-α
T18639 8489-8491 Protein denotes GR
T18640 8560-8566 Protein denotes GATA-3
T18641 8503-8510 Binding denotes binding
T18642 8550-8559 Positive_regulation denotes activated
T18643 8602-8604 Protein denotes GR
T18644 8592-8601 Positive_regulation denotes activated
T18645 8636-8639 Protein denotes CD3
T18646 8640-8644 Protein denotes CD28
T18647 8681-8683 Protein denotes GR
T18648 8751-8753 Protein denotes GR
T18649 8819-8822 Protein denotes CD3
T18650 8823-8827 Protein denotes CD28
T18651 8741-8750 Positive_regulation denotes Activated
T18652 9008-9023 Protein denotes GATA-3-importin
T18653 9024-9031 Binding denotes binding
T18654 9089-9091 Protein denotes GR
T18655 9110-9125 Protein denotes GATA-3–importin
T18656 9051-9060 Positive_regulation denotes activated
T18657 9290-9295 Protein denotes ANOVA
T19202 10308-10311 Protein denotes CD3
T19203 10312-10316 Protein denotes CD28
T19204 10335-10342 Entity denotes nuclear
T19205 10343-10355 Localization denotes localization
T19206 10343-10355 Localization denotes localization
T19207 10295-10302 Negative_regulation denotes prevent
T19208 10295-10302 Negative_regulation denotes prevent
T19209 10258-10264 Regulation denotes affect
T19210 10258-10264 Regulation denotes affect
T19211 2354-2357 Protein denotes CD3
T19212 2358-2362 Protein denotes CD28
T19213 10598-10604 Protein denotes GATA-3
T19214 10665-10673 Protein denotes anti-CD3
T19215 10674-10678 Protein denotes CD28
T19216 10608-10621 Gene_expression denotes overexpressed
T19217 10761-10769 Protein denotes anti-CD3
T19218 10770-10774 Protein denotes CD28
T19219 10828-10831 Protein denotes CD3
T19220 10832-10836 Protein denotes CD28
T19221 10848-10851 Protein denotes p65
T19222 10852-10859 Entity denotes nuclear
T19223 10860-10873 Localization denotes translocation
T19224 10860-10873 Localization denotes translocation
T19225 10860-10873 Localization denotes translocation
T19226 10815-10822 Negative_regulation denotes prevent
T19227 10815-10822 Negative_regulation denotes prevent
T19228 10815-10822 Negative_regulation denotes prevent
T19229 11068-11073 Protein denotes ANOVA
T19610 11681-11691 Protein denotes importin-α
T19611 11696-11702 Protein denotes GATA-3
T19612 11664-11675 Binding denotes interaction
T19613 11664-11675 Binding denotes interaction
T19614 11703-11710 Entity denotes nuclear
T19615 11711-11723 Localization denotes localization
T19616 11711-11723 Localization denotes localization
T19617 11844-11846 Protein denotes FP
T19618 11898-11904 Protein denotes GATA-3
T19619 11909-11919 Protein denotes importin-α
T19620 11878-11889 Binding denotes interaction
T19621 12279-12285 Protein denotes GATA-3
T19622 12290-12300 Protein denotes importin-α
T19623 12259-12270 Binding denotes association
T19624 12249-12258 Negative_regulation denotes decreased
T19625 12415-12425 Protein denotes importin-α
T19626 12469-12471 Protein denotes FP
T19627 12426-12436 Gene_expression denotes expression
T19628 12441-12451 Regulation denotes unaffected
T20308 14977-14979 Protein denotes GR
T20309 14984-15011 Protein denotes GATA-3 nuclear localisation
T20310 15017-15031 Protein denotes Nuclear GATA-3
T20311 15421-15427 Protein denotes GATA-3
T20312 15443-15461 Protein denotes cytoplasmic GATA-3
T20313 15493-15495 Protein denotes FP
T20314 15399-15406 Entity denotes nuclear
T20315 15407-15417 Gene_expression denotes expression
T20316 15462-15472 Gene_expression denotes expression
T20317 15479-15489 Negative_regulation denotes inhalation
T20318 15387-15395 Negative_regulation denotes decrease
T20319 15387-15395 Negative_regulation denotes decrease
T20320 15433-15442 Positive_regulation denotes increased
T20321 15598-15604 Protein denotes GATA-3
T20322 15674-15676 Protein denotes FP
T20323 15576-15583 Entity denotes nuclear
T20324 15584-15594 Gene_expression denotes expression
T20325 15564-15572 Negative_regulation denotes decrease
T20326 15678-15688 Protein denotes Histone H1
T20327 15693-15698 Protein denotes MEK-1
T20328 16133-16136 Protein denotes p38
T20329 16116-16128 Entity denotes tyrosine-182
T20330 16081-16096 Phosphorylation denotes phosphorylation
T20331 16064-16072 Negative_regulation denotes decrease
T10934 5394-5403 Negative_regulation denotes decreased
T10921 5127-5135 Protein denotes p38 MAPK
T10922 5211-5234 Protein denotes dual kinase phosphatase
T10923 5235-5240 Protein denotes MKP-1
T10924 5242-5246 Protein denotes MAPK
T10925 5194-5203 Positive_regulation denotes induction
T10926 5194-5203 Positive_regulation denotes induction
T10927 5118-5126 Negative_regulation denotes inhibits
T10928 5118-5126 Negative_regulation denotes inhibits
T10929 5362-5365 Protein denotes CD3
T10930 5366-5370 Protein denotes CD28
T10931 5404-5407 Protein denotes p38
T10932 5408-5412 Entity denotes MAPK
T10933 5413-5428 Phosphorylation denotes phosphorylation
T10935 5642-5648 Protein denotes GATA-3
T10936 5688-5691 Protein denotes CD3
T10937 5692-5696 Protein denotes CD28
T10938 5649-5655 Entity denotes serine
T10939 5656-5671 Phosphorylation denotes phosphorylation
T10940 5672-5679 Positive_regulation denotes induced
T10941 5634-5641 Negative_regulation denotes reduced
T10942 5791-5797 Protein denotes GATA-3
T18193 7135-7145 Protein denotes MKP-1 mRNA
T18194 7127-7134 Positive_regulation denotes induced
T18195 7326-7336 Protein denotes MKP-1 mRNA
T18196 7318-7325 Positive_regulation denotes induces
T18197 7461-7466 Protein denotes ANOVA
R7579 T8773 T8775 themeOf GATA-3 Nuclear Translocation,Effect
R7580 T8774 T8776 themeOf IL-4 mRNA,Effect
R7581 T8777 T8778 themeOf GATA-3-regulated IL-4 gene,expression
R7582 T8778 T8779 themeOf expression,inhibiting
R7583 T8780 T8784 themeOf anti-CD3,import
R7584 T8782 T8785 themeOf GATA-3,import
R7585 T8783 T8784 locationOf nuclear,import
R7586 T8783 T8785 locationOf nuclear,import
R7587 T8784 T8786 themeOf import,affect
R7588 T8785 T8787 themeOf import,affect
R7589 T8792 T8793 themeOf GATA-3,retention
R7590 T8793 T8794 themeOf retention,loss
R7633 T8849 T8861 causeOf CD28,stimulated
R7634 T8849 T8862 causeOf CD28,stimulated
R7635 T8850 T8854 themeOf IL-4,expression
R7636 T8851 T8855 themeOf IL-5 mRNA,expression
R7637 T8852 T8856 themeOf GATA-3,loss
R7638 T8852 T8857 themeOf GATA-3,binding
R7639 T8852 T8858 themeOf GATA-3,binding
R7640 T8853 T8858 themeOf IL-5 promoter,binding
R7641 T8854 T8859 themeOf expression,reductions
R7642 T8854 T8861 themeOf expression,stimulated
R7643 T8855 T8860 themeOf expression,reductions
R7644 T8855 T8862 themeOf expression,stimulated
R7645 T8857 T8863 themeOf binding,loss
R7646 T8858 T8864 themeOf binding,loss
R8047 T9334 T9337 themeOf GR,Ligand-Activated
R8048 T9338 T9341 themeOf GR,ligand-activated
R8049 T9339 T9342 themeOf GATA-3,ligand-activated
R8050 T9340 T9344 themeOf importin-α,import
R8051 T9343 T9344 locationOf nuclear,import
R8052 T9345 T9347 themeOf GR,interaction
R8053 T9346 T9347 themeOf importin-α,interaction
R8054 T9348 T9350 themeOf GR,translocation
R8055 T9349 T9350 locationOf nuclear,translocation
R8056 T9351 T9355 themeOf GATA-3,association
R8057 T9352 T9355 themeOf importin-α,association
R8058 T9355 T9356 themeOf association,decreased
R9378 T10922 T10925 themeOf dual kinase phosphatase,induction
R9379 T10923 T10926 themeOf MKP-1,induction
R9380 T10925 T10927 themeOf induction,inhibits
R9381 T10926 T10928 themeOf induction,inhibits
R9382 T10931 T10933 themeOf p38,phosphorylation
R9383 T10931 T10932 partOf p38,MAPK
R9384 T10932 T10933 Site MAPK,phosphorylation
R9385 T10933 T10934 themeOf phosphorylation,decreased
R9386 T10935 T10939 themeOf GATA-3,phosphorylation
R9387 T10935 T10938 partOf GATA-3,serine
R9388 T10938 T10939 Site serine,phosphorylation
R9389 T10939 T10940 themeOf phosphorylation,induced
R9390 T10939 T10941 themeOf phosphorylation,reduced
R9391 T10942 T10944 themeOf GATA-3,phosphorylation
R9392 T10944 T10945 themeOf phosphorylation,reduction
R9393 T10946 T10948 causeOf FP,induced
R9394 T10947 T10948 themeOf MKP-1 mRNA,induced
R9395 T10949 T10950 themeOf IL-4 mRNA,expression
R9396 T10950 T10951 themeOf expression,effects
R9397 T10952 T10957 themeOf GATA-3,activated
R9398 T10953 T10958 themeOf importin-α,activated
R9399 T10954 T10959 themeOf GR,activated
R9400 T10955 T10960 themeOf GR,activated
R9401 T10961 T10963 themeOf GATA-3,activated
R9402 T10964 T10966 themeOf GR,activated
R9403 T10964 T10967 themeOf GR,associate
R9404 T10965 T10968 themeOf GR,activated
R9405 T10969 T10970 themeOf GR,ligand-activated
R9406 T10971 T10972 themeOf FP,affect
R9407 T10974 T10975 themeOf FP,expression
R9408 T10974 T10976 causeOf FP,effect
R9409 T10975 T10976 themeOf expression,effect
R9410 T10977 T10982 themeOf FP,translocation
R9411 T10978 T10983 themeOf CD3,translocation
R9412 T10979 T10984 themeOf CD28,translocation
R9413 T10980 T10985 themeOf GR,activated
R9414 T10981 T10982 locationOf nuclear,translocation
R9415 T10981 T10983 locationOf nuclear,translocation
R9416 T10981 T10984 locationOf nuclear,translocation
R9417 T10986 T10989 themeOf p65,translocation
R9418 T10988 T10989 locationOf nuclear,translocation
R9419 T10989 T10990 themeOf translocation,effect
R11016 T12798 T12800 themeOf phospho-GATA-3,interaction
R11017 T12799 T12800 themeOf importin-α,interaction
R11018 T12800 T12801 themeOf interaction,decrease
R11019 T12802 T12808 causeOf M FP,suppresses
R11020 T12803 T12806 themeOf IL-4,expression
R11021 T12804 T12807 themeOf GATA-3,interaction
R11022 T12805 T12807 themeOf importin-α,interaction
R11023 T12806 T12808 themeOf expression,suppresses
R11024 T12807 T12809 themeOf interaction,attenuated
R11025 T12810 T12812 themeOf GATA-3–importin,interaction
R11026 T12811 T12812 themeOf α,interaction
R11027 T12812 T12813 themeOf interaction,reduced
R11028 T12815 T12818 themeOf GATA-3,interaction
R11029 T12817 T12819 themeOf importin-α,abundance
R11030 T12819 T12820 themeOf abundance,decrease
R11031 T12821 T12823 themeOf GATA-3,localization
R11032 T12822 T12823 locationOf cellular,localization
R11033 T12824 T12826 themeOf GR,translocation
R11034 T12825 T12826 locationOf nuclear,translocation
R11035 T12826 T12827 themeOf translocation,increased
R11036 T12828 T12831 themeOf cytoplasmic GATA-3,enhanced
R11037 T12829 T12831 causeOf FP,enhanced
R11038 T12832 T12833 themeOf p38 MAPK,phosphorylation
R11039 T12833 T12834 themeOf phosphorylation,inhibited
R11040 T12835 T12837 themeOf GATA-3,localization
R11041 T12836 T12837 locationOf nuclear,localization
R11042 T12837 T12838 themeOf localization,reduces
R11043 T12839 T12842 themeOf importin-α,competition
R11044 T12840 T12843 themeOf p38,phosphorylation
R11045 T12841 T12844 themeOf MKP-1,induction
R14335 T16705 T16707 themeOf GATA-3,translocation
R14336 T16706 T16707 locationOf nucleus,translocation
R14337 T16710 T16714 themeOf GATA-3,localization
R14338 T16713 T16714 locationOf nuclear,localization
R14339 T16714 T16715 themeOf localization,induced
R14340 T16714 T16716 themeOf localization,impaired
R14341 T16719 T16726 causeOf FP,inhibits
R14342 T16719 T16727 causeOf FP,inhibits
R14343 T16720 T16724 themeOf IL-4,expression
R14344 T16721 T16725 themeOf IL-5 mRNA,expression
R14345 T16724 T16726 themeOf expression,inhibits
R14346 T16725 T16727 themeOf expression,inhibits
R14347 T16732 T16735 causeOf CD28,stimulated
R14348 T16733 T16735 themeOf GATA-3,stimulated
R14349 T16733 T16736 themeOf GATA-3,associate
R14350 T16734 T16736 themeOf IL-5 promoter 60 min,associate
R14351 T16735 T16737 themeOf stimulated,reduces
R15022 T17504 T17507 themeOf GATA-3,association
R15023 T17505 T17507 themeOf importin-α,association
R15024 T17505 T17509 themeOf importin-α,import
R15025 T17506 T17510 themeOf GATA-3,import
R15026 T17507 T17511 themeOf association,reduces
R15027 T17508 T17509 locationOf nuclear,import
R15028 T17508 T17510 locationOf nuclear,import
R15029 T17512 T17519 causeOf FP,activated
R15030 T17512 T17520 causeOf FP,activated
R15031 T17512 T17521 causeOf FP,activated
R15032 T17513 T17516 themeOf GR,interaction
R15033 T17513 T17517 themeOf GR,interaction
R15034 T17513 T17518 themeOf GR,interaction
R15035 T17514 T17517 themeOf importin-α,interaction
R15036 T17515 T17518 themeOf Imp-α,interaction
R15037 T17516 T17519 themeOf interaction,activated
R15038 T17517 T17520 themeOf interaction,activated
R15039 T17518 T17521 themeOf interaction,activated
R15040 T17519 T17522 themeOf activated,induction
R15041 T17520 T17523 themeOf activated,induction
R15042 T17521 T17524 themeOf activated,induction
R15043 T17525 T17527 themeOf GR,association
R15044 T17526 T17527 themeOf importin,association
R15045 T17527 T17528 themeOf association,control
R15046 T17529 T17533 causeOf FP,activated
R15047 T17530 T17532 themeOf GR,translocation
R15048 T17531 T17532 locationOf nuclear,translocation
R15049 T17532 T17533 themeOf translocation,activated
R15050 T17533 T17534 themeOf activated,induction
R15051 T17541 T17544 themeOf GATA-3,overexpressed
R15052 T17544 T17545 themeOf overexpressed,overexpressed
R15571 T18168 T18170 themeOf p38 MAP kinase,inhibition
R15572 T18168 T18171 themeOf p38 MAP kinase,phosphorylation
R15573 T18169 T18173 themeOf GATA-3,phosphorylation
R15574 T18169 T18172 partOf GATA-3,serine
R15575 T18171 T18174 themeOf phosphorylation,inhibition
R15576 T18172 T18173 Site serine,phosphorylation
R15577 T18173 T18175 themeOf phosphorylation,down-regulation
R15578 T18176 T18180 themeOf p38 MAPK,phosphorylation
R15579 T18176 T18179 partOf p38 MAPK,tyrosine-182
R15580 T18179 T18180 Site tyrosine-182,phosphorylation
R15581 T18180 T18181 themeOf phosphorylation,reduced
R15582 T18182 T18183 themeOf p38 MAPK,phosphorylation
R15583 T18184 T18188 themeOf p38 MAPK,inhibition
R15584 T18185 T18189 partOf anti-CD3,serine
R15585 T18186 T18189 partOf CD28,serine
R15586 T18187 T18189 partOf GATA-3,serine
R15587 T18187 T18190 partOf GATA-3,P-Ser
R15588 T18193 T18194 themeOf MKP-1 mRNA,induced
R15589 T18195 T18196 themeOf MKP-1 mRNA,induces
R15928 T18639 T18641 themeOf GR,binding
R15929 T18640 T18642 themeOf GATA-3,activated
R15930 T18643 T18644 themeOf GR,activated
R15931 T18648 T18651 themeOf GR,Activated
R15932 T18652 T18653 themeOf GATA-3-importin,binding
R15933 T18654 T18656 themeOf GR,activated
R16400 T19202 T19205 themeOf CD3,localization
R16401 T19203 T19206 themeOf CD28,localization
R16402 T19204 T19205 locationOf nuclear,localization
R16403 T19204 T19206 locationOf nuclear,localization
R16404 T19205 T19207 themeOf localization,prevent
R16405 T19206 T19208 themeOf localization,prevent
R16406 T19207 T19209 themeOf prevent,affect
R16407 T19208 T19210 themeOf prevent,affect
R16408 T19213 T19216 themeOf GATA-3,overexpressed
R16409 T19219 T19223 themeOf CD3,translocation
R16410 T19220 T19224 themeOf CD28,translocation
R16411 T19221 T19225 themeOf p65,translocation
R16412 T19222 T19223 locationOf nuclear,translocation
R16413 T19222 T19224 locationOf nuclear,translocation
R16414 T19222 T19225 locationOf nuclear,translocation
R16415 T19223 T19226 themeOf translocation,prevent
R16416 T19224 T19227 themeOf translocation,prevent
R16417 T19225 T19228 themeOf translocation,prevent
R16754 T19610 T19612 themeOf importin-α,interaction
R16755 T19610 T19613 themeOf importin-α,interaction
R16756 T19610 T19615 themeOf importin-α,localization
R16757 T19611 T19613 themeOf GATA-3,interaction
R16758 T19611 T19616 themeOf GATA-3,localization
R16759 T19614 T19615 locationOf nuclear,localization
R16760 T19614 T19616 locationOf nuclear,localization
R16761 T19618 T19620 themeOf GATA-3,interaction
R16762 T19619 T19620 themeOf importin-α,interaction
R16763 T19621 T19623 themeOf GATA-3,association
R16764 T19622 T19623 themeOf importin-α,association
R16765 T19623 T19624 themeOf association,decreased
R16766 T19625 T19627 themeOf importin-α,expression
R16767 T19626 T19628 causeOf FP,unaffected
R16768 T19627 T19628 themeOf expression,unaffected
R17370 T20311 T20315 themeOf GATA-3,expression
R17371 T20312 T20316 themeOf cytoplasmic GATA-3,expression
R17372 T20313 T20317 themeOf FP,inhalation
R17373 T20315 T20318 themeOf expression,decrease
R17374 T20316 T20319 themeOf expression,decrease
R17375 T20316 T20320 themeOf expression,increased
R17376 T20317 T20318 causeOf inhalation,decrease
R17377 T20317 T20319 causeOf inhalation,decrease
R17378 T20321 T20324 themeOf GATA-3,expression
R17379 T20324 T20325 themeOf expression,decrease
R17380 T20328 T20330 themeOf p38,phosphorylation
R17381 T20328 T20329 partOf p38,tyrosine-182
R17382 T20329 T20330 Site tyrosine-182,phosphorylation
R17383 T20330 T20331 themeOf phosphorylation,decrease

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T8186 13-19 Regulation denotes Effect
T8187 42-48 Protein denotes GATA-3
T8188 49-56 Entity denotes Nuclear
T8189 57-70 Localization denotes Translocation
T8190 75-79 Protein denotes IL-4
T8191 105-114 Regulation denotes effective
T8192 118-128 Negative_regulation denotes inhibiting
T8193 129-135 Protein denotes GATA-3
T8194 136-145 Regulation denotes regulated
T8195 146-150 Protein denotes IL-4
T8196 156-166 Gene_expression denotes expression
T8197 244-250 Regulation denotes affect true
T8198 265-275 Positive_regulation denotes stimulated
T8199 276-283 Entity denotes nuclear
T8200 284-290 Localization denotes import
T8201 294-300 Protein denotes GATA-3
T8202 342-350 Positive_regulation denotes resulted
T8203 374-381 Entity denotes nuclear
T8204 382-388 Protein denotes GATA-3
T8205 389-402 Localization denotes translocation
T8206 557-562 Protein denotes MEK-1
T8207 621-627 Positive_regulation denotes caused
T8208 621-627 Positive_regulation denotes caused
T8209 638-642 Negative_regulation denotes loss
T8210 646-653 Entity denotes nuclear
T8211 654-660 Protein denotes GATA-3
T8212 661-671 Localization denotes expression
T8213 676-687 Entity denotes cytoplasmic
T8214 688-697 Localization denotes retention
T8215 701-707 Protein denotes GATA-3
T8216 796-807 Regulation denotes This effect
T8217 796-807 Regulation denotes This effect
T8218 796-807 Regulation denotes This effect
T8219 836-845 Regulation denotes dependent
T8220 836-845 Regulation denotes dependent
T8221 836-845 Regulation denotes dependent
T8222 938-948 Regulation denotes associated
T8223 938-948 Regulation denotes associated
T8224 938-948 Regulation denotes associated
T8225 961-971 Negative_regulation denotes reductions
T8226 961-971 Negative_regulation denotes reductions
T8227 989-999 Positive_regulation denotes stimulated
T8228 989-999 Positive_regulation denotes stimulated
T8229 1000-1004 Protein denotes IL-4
T8230 1009-1013 Protein denotes IL-5
T8231 1014-1029 Transcription denotes mRNA expression
T8232 1014-1029 Transcription denotes mRNA expression
T8233 1048-1052 Negative_regulation denotes loss
T8234 1056-1062 Protein denotes GATA-3
T8235 1063-1070 Binding denotes binding
T8236 1085-1089 Protein denotes IL-5
T8237 1090-1098 Entity denotes promoter
T8929 3172-3181 Negative_regulation denotes decreased
T8930 3186-3197 Binding denotes association
T8931 3206-3212 Protein denotes GATA-3
T8932 3228-3235 Positive_regulation denotes induced
T8933 3284-3293 Regulation denotes dependent
T8934 3333-3352 Protein denotes GFP-labelled GATA-3
T8935 3398-3404 Protein denotes GATA-3
T8936 3405-3412 Entity denotes nuclear
T8937 3413-3419 Localization denotes import
T8938 3420-3429 Positive_regulation denotes following
T8939 3471-3481 Negative_regulation denotes attenuated
T9602 5906-5910 Transcription denotes mRNA
T9603 5945-5954 Regulation denotes dependent
T9604 6038-6045 Regulation denotes effects
T9605 6038-6045 Regulation denotes effects
T9606 6038-6045 Regulation denotes effects
T9607 6055-6061 Protein denotes GATA-3
T9608 6062-6069 Entity denotes nuclear
T9609 6070-6076 Localization denotes import
T9610 6089-6100 Binding denotes association
T9611 6105-6109 Protein denotes IL-4
T9612 6110-6125 Transcription denotes mRNA expression
T9613 7523-7534 Negative_regulation denotes competition
T9614 7523-7534 Negative_regulation denotes competition
T9615 7572-7581 Positive_regulation denotes activated
T9616 7582-7588 Protein denotes GATA-3
T9617 7606-7615 Positive_regulation denotes activated
T9618 7616-7618 Protein denotes GR
T9619 7641-7650 Positive_regulation denotes activated
T9633 7912-7914 Protein denotes GR
T9634 7927-7933 Protein denotes GATA-3
T9635 7947-7956 Binding denotes associate
T9636 7947-7956 Binding denotes associate
T9637 7994-8003 Positive_regulation denotes activated
T9638 8004-8006 Protein denotes GR
T9639 8007-8017 Negative_regulation denotes attenuates
T9640 8022-8029 Phosphorylation denotes phospho
T9641 8030-8036 Protein denotes GATA-3
T9642 8048-8059 Binding denotes interaction
T9643 8079-8088 Regulation denotes dependent
T9644 8145-8154 Positive_regulation denotes activated
T9645 8155-8157 Protein denotes GR
T9646 8162-8169 Negative_regulation denotes compete true
T9647 8183-8189 Protein denotes GATA-3
T9648 8190-8193 Binding denotes for
T9649 8217-8222 Negative_regulation denotes limit
T9650 8223-8229 Protein denotes GATA-3
T9651 8230-8237 Entity denotes nuclear
T9652 8238-8244 Localization denotes import
T9653 9397-9403 Regulation denotes effect
T9654 9397-9403 Regulation denotes effect
T9655 9413-9419 Protein denotes GATA-3
T9656 9420-9427 Entity denotes nuclear
T9657 9428-9434 Localization denotes export
T9658 9442-9453 Protein_catabolism denotes degradation
T9659 9508-9514 Regulation denotes affect true
T9660 9536-9541 Negative_regulation denotes block
T9661 9542-9548 Protein denotes GATA-3
T9662 9549-9556 Entity denotes nuclear
T9663 9557-9569 Localization denotes localization
T9664 9607-9613 Regulation denotes effect true
T9665 9628-9634 Protein denotes GATA-3
T9666 9635-9645 Gene_expression denotes expression
T9667 9776-9782 Regulation denotes affect true
T9668 9783-9789 Protein denotes GATA-3
T9669 9790-9797 Entity denotes nuclear
T9670 9798-9807 Localization denotes residency
T9671 9837-9846 Positive_regulation denotes activated
T9672 9847-9849 Protein denotes GR
T9673 9859-9866 Positive_regulation denotes enhance true
T9674 9867-9873 Protein denotes GATA-3
T9675 9874-9881 Entity denotes nuclear
T9676 9882-9888 Localization denotes export
T9677 9903-9909 Regulation denotes effect
T9678 9919-9925 Protein denotes GATA-3
T9679 9926-9933 Entity denotes nuclear
T9680 9934-9940 Localization denotes import
T9681 9987-9993 Regulation denotes effect true
T9682 9997-10000 Protein denotes p65
T9683 10001-10008 Entity denotes nuclear
T9684 10009-10022 Localization denotes translocation
T11235 12590-12600 Negative_regulation denotes suppresses
T11236 12590-12600 Negative_regulation denotes suppresses
T11237 12601-12605 Protein denotes IL-4
T11238 12610-12612 Protein denotes -5
T11239 12618-12628 Gene_expression denotes expression
T11240 12618-12628 Gene_expression denotes expression
T11241 12633-12643 Negative_regulation denotes attenuated
T11242 12648-12659 Binding denotes interaction
T11243 12663-12669 Protein denotes GATA-3
T11244 12915-12922 Negative_regulation denotes reduced
T11245 12923-12929 Protein denotes GATA-3
T11246 12941-12952 Binding denotes interaction
T11247 12971-12980 Regulation denotes dependent
T11248 12994-13002 Regulation denotes produced
T11249 13010-13018 Negative_regulation denotes decrease
T11250 13022-13028 Protein denotes GATA-3
T11251 13040-13051 Binding denotes association
T11252 13320-13326 Protein denotes GATA-3
T11253 13338-13349 Binding denotes association
T11254 13436-13446 Negative_regulation denotes attenuated
T11255 13447-13458 Binding denotes interaction
T11256 13462-13468 Protein denotes GATA-3
T11257 13684-13690 Regulation denotes affect true
T11258 13700-13712 Localization denotes localization
T11259 13716-13722 Protein denotes GATA-3
T11260 13809-13818 Positive_regulation denotes increased
T11261 13819-13821 Protein denotes GR
T11262 13822-13829 Entity denotes nuclear
T11263 13830-13843 Localization denotes translocation
T11264 13906-13912 Protein denotes GATA-3
T11265 14261-14268 Positive_regulation denotes induced
T11266 14281-14285 Localization denotes loss true
T11267 14289-14296 Entity denotes nuclear
T11268 14297-14303 Protein denotes GATA-3
T11269 14428-14439 Entity denotes cytoplasmic
T11270 14440-14446 Protein denotes GATA-3
T11271 14447-14453 Localization denotes levels
T11272 14459-14467 Positive_regulation denotes enhanced
T16000 1227-1235 Negative_regulation denotes inhibits
T16001 1236-1242 Protein denotes GATA-3
T16002 1243-1250 Entity denotes nuclear
T16003 1251-1257 Localization denotes import
T16004 1314-1327 Localization denotes translocation
T16005 1331-1337 Protein denotes GATA-3
T16006 1364-1371 Entity denotes nucleus
T16007 1406-1411 Protein denotes MEK-1
T16008 1595-1602 Entity denotes nuclear
T16009 1603-1615 Localization denotes localization
T16010 1619-1625 Protein denotes GATA-3
T16011 1626-1633 Positive_regulation denotes induced
T16012 1822-1826 Protein denotes MEK1
T16013 2072-2080 Negative_regulation denotes inhibits
T16014 2072-2080 Negative_regulation denotes inhibits
T16015 2081-2085 Protein denotes IL-4
T16016 2090-2094 Protein denotes IL-5
T16017 2095-2110 Transcription denotes mRNA expression
T16018 2095-2110 Transcription denotes mRNA expression
T16019 2114-2117 Protein denotes CD3
T16020 2118-2122 Protein denotes CD28
T16021 2123-2135 Regulation denotes costimulated
T16022 2123-2135 Regulation denotes costimulated
T16023 2390-2397 Negative_regulation denotes reduces
T16024 2427-2437 Positive_regulation denotes stimulated
T16025 2438-2444 Protein denotes GATA-3
T16026 2448-2457 Binding denotes associate
T16027 2474-2478 Protein denotes IL-5
T16028 2479-2487 Entity denotes promoter
T17583 6335-6345 Regulation denotes associated
T17584 6360-6375 Negative_regulation denotes down-regulation
T17585 6379-6385 Protein denotes GATA-3
T17586 6386-6392 Entity denotes serine
T17587 6393-6408 Phosphorylation denotes phosphorylation
T17588 6619-6625 Regulation denotes effect
T17589 6644-6659 Phosphorylation denotes phosphorylation
T17590 6663-6695 Protein denotes activated transcription factor 2
T17591 6697-6702 Protein denotes ATF-2
T17592 6807-6815 Negative_regulation denotes decrease
T17593 6848-6855 Positive_regulation denotes induced
T17594 6856-6862 Entity denotes serine
T17595 6863-6878 Phosphorylation denotes phosphorylation
T17596 6890-6896 Protein denotes GATA-3
T17597 7127-7134 Positive_regulation denotes induced
T17598 7135-7140 Protein denotes MKP-1
T17599 7165-7174 Regulation denotes dependent
T17600 7318-7325 Positive_regulation denotes induces
T17601 7326-7331 Protein denotes MKP-1
T17602 7347-7356 Regulation denotes dependent
T18278 8327-8334 Phosphorylation denotes phospho
T18279 8335-8341 Protein denotes GATA-3
T18280 8434-8436 Protein denotes GR
T18281 8480-8488 Positive_regulation denotes enhances
T18282 8489-8491 Protein denotes GR
T18283 8503-8510 Binding denotes binding
T18284 8560-8566 Protein denotes GATA-3
T18285 8592-8601 Positive_regulation denotes activated
T18286 8602-8604 Protein denotes GR
T18287 8610-8616 Protein denotes GATA-3
T18288 8671-8680 Negative_regulation denotes attenuate true
T18289 8681-8683 Protein denotes GR
T18290 8695-8706 Binding denotes association
T18291 8741-8750 Positive_regulation denotes Activated
T18292 8751-8753 Protein denotes GR
T18293 8754-8760 Negative_regulation denotes blocks
T18294 8785-8792 Phosphorylation denotes phospho
T18295 8793-8799 Protein denotes GATA-3
T18296 8845-8856 Binding denotes interacting
T18297 8935-8941 Protein denotes GATA-3
T18298 8997-9007 Positive_regulation denotes stimulated
T18299 9008-9014 Protein denotes GATA-3
T18300 9024-9031 Binding denotes binding
T18301 9051-9060 Positive_regulation denotes activated
T18302 9072-9084 Positive_regulation denotes unstimulated true
T18303 9089-9091 Protein denotes GR
T18304 9095-9106 Negative_regulation denotes attenuation
T18305 9110-9116 Protein denotes GATA-3
T18306 9128-9139 Binding denotes association
T18307 9158-9167 Regulation denotes dependent
T18706 10560-10571 Protein_catabolism denotes degradation
T18707 10598-10604 Protein denotes GATA-3
T18708 10815-10822 Negative_regulation denotes prevent true
T18709 10837-10847 Positive_regulation denotes stimulated
T18710 10848-10851 Protein denotes p65
T18711 10852-10859 Entity denotes nuclear
T18712 10860-10873 Localization denotes translocation
T19698 14844-14851 Negative_regulation denotes impairs
T19699 14852-14858 Protein denotes GATA-3
T19700 14859-14866 Entity denotes nuclear
T19701 14867-14879 Localization denotes localization
T19702 14977-14979 Protein denotes GR
T19703 14984-14990 Protein denotes GATA-3
T19704 14991-14998 Entity denotes nuclear
T19705 14999-15011 Localization denotes localisation
T19706 14999-15011 Localization denotes localisation
T19707 15025-15031 Protein denotes GATA-3
T19708 15377-15386 Regulation denotes dependent
T19709 15377-15386 Regulation denotes dependent
T19710 15387-15395 Negative_regulation denotes decrease
T19711 15399-15406 Entity denotes nuclear
T19712 15407-15417 Localization denotes expression
T19713 15421-15427 Protein denotes GATA-3
T19714 15433-15442 Positive_regulation denotes increased
T19715 15443-15454 Entity denotes cytoplasmic
T19716 15455-15461 Protein denotes GATA-3
T19717 15462-15472 Localization denotes expression
T19718 15564-15572 Negative_regulation denotes decrease
T19719 15576-15583 Entity denotes nuclear
T19720 15584-15594 Localization denotes expression
T19721 15598-15604 Protein denotes GATA-3
T19722 15620-15631 Entity denotes cytoplasmic
T19723 15632-15638 Protein denotes GATA-3
T19724 15639-15649 Localization denotes expression
T19725 15693-15698 Protein denotes MEK-1
T8185 13-19 Regulation denotes Effect
T18695 10131-10137 Regulation denotes affect true
T18696 10138-10144 Protein denotes GATA-3
T18697 10153-10159 Localization denotes export
T18698 10258-10264 Regulation denotes affect true
T18699 10295-10302 Negative_regulation denotes prevent
T18700 10317-10327 Positive_regulation denotes stimulated
T18701 10328-10334 Protein denotes GATA-3
T18702 10335-10342 Entity denotes nuclear
T18703 10343-10355 Localization denotes localization
T18704 10535-10541 Regulation denotes affect true
T18705 10553-10559 Protein denotes GATA-3
T11224 11110-11120 Negative_regulation denotes Inhibitory
T11225 11150-11156 Protein denotes GATA-3
T11226 11157-11164 Entity denotes Nuclear
T11227 11165-11177 Localization denotes Localization
T11228 11278-11287 Regulation denotes dependent
T11229 11288-11296 Negative_regulation denotes decrease
T11230 11311-11322 Binding denotes interaction
T11231 11331-11338 Phosphorylation denotes phospho
T11232 11339-11345 Protein denotes GATA-3
T11233 11440-11449 Negative_regulation denotes inhibited
T11234 11518-11528 Negative_regulation denotes attenuated
T11273 14492-14501 Regulation denotes dependent
T11274 16304-16311 Negative_regulation denotes reduces
T11275 16312-16319 Entity denotes nuclear
T11276 16320-16332 Localization denotes localization
T11277 16336-16342 Protein denotes GATA-3
T11278 16362-16372 Negative_regulation denotes inhibiting
T11279 16381-16387 Protein denotes GATA-3
T11280 16397-16408 Binding denotes association
T11281 16535-16543 Positive_regulation denotes mediated
T11282 16544-16550 Protein denotes GATA-3
T11283 16551-16566 Phosphorylation denotes phosphorylation
T11284 16577-16586 Gene_expression denotes induction
T11285 16590-16595 Protein denotes MKP-1
T11286 16638-16645 Regulation denotes effects
T11287 16669-16680 Negative_regulation denotes suppression
T11288 16684-16690 Protein denotes GATA-3
T11289 16691-16698 Entity denotes nuclear
T11290 16699-16705 Localization denotes import
T8914 2678-2680 Protein denotes GR
T8915 2695-2701 Protein denotes GATA-3
T8916 2702-2705 Binding denotes for
T8917 2782-2791 Positive_regulation denotes activated
T8918 2792-2794 Protein denotes GR
T8919 2806-2812 Protein denotes GATA-3
T8920 2813-2817 Positive_regulation denotes uses
T8921 2813-2817 Positive_regulation denotes uses
T8922 2837-2844 Entity denotes nuclear
T8923 2845-2851 Localization denotes import
T8924 2845-2851 Localization denotes import
T8925 2897-2899 Protein denotes GR
T8926 3010-3012 Protein denotes GR
T8927 3013-3020 Entity denotes nuclear
T8928 3021-3034 Localization denotes translocation
T9583 5098-5103 Protein denotes MKP-1
T9584 5194-5203 Gene_expression denotes induction
T9585 5235-5240 Protein denotes MKP-1
T9586 5242-5260 Protein denotes MAPK phosphatase-1
T9587 5394-5403 Negative_regulation denotes decreased
T9588 5466-5481 Phosphorylation denotes phosphorylation
T9589 5500-5506 Binding denotes target
T9590 5507-5512 Protein denotes ATF-2
T9591 5634-5641 Negative_regulation denotes reduced
T9592 5642-5648 Protein denotes GATA-3
T9593 5649-5655 Entity denotes serine
T9594 5656-5671 Phosphorylation denotes phosphorylation
T9595 5672-5679 Positive_regulation denotes induced
T9596 5743-5752 Regulation denotes dependent
T9597 5773-5787 Negative_regulation denotes This reduction
T9598 5791-5797 Protein denotes GATA-3
T9599 5798-5813 Phosphorylation denotes phosphorylation
T9600 5892-5899 Positive_regulation denotes induced
T9601 5900-5905 Protein denotes MKP-1
T9620 7651-7653 Protein denotes GR
T9621 7668-7677 Positive_regulation denotes increased
T9622 7678-7680 Protein denotes GR
T9623 7692-7703 Binding denotes association
T9624 7704-7734 Regulation denotes in the presence and absence of true
T9625 7735-7744 Positive_regulation denotes activated
T9626 7745-7751 Protein denotes GATA-3
T9627 7798-7807 Positive_regulation denotes activated
T9628 7808-7814 Protein denotes GATA-3
T9629 7823-7828 Negative_regulation denotes block true
T9630 7829-7831 Protein denotes GR
T9631 7843-7854 Binding denotes association
T9632 7902-7911 Positive_regulation denotes activated
T16789 3595-3602 Negative_regulation denotes reduces
T16790 3595-3602 Negative_regulation denotes reduces
T16791 3603-3609 Protein denotes GATA-3
T16792 3610-3621 Binding denotes association
T16793 3642-3648 Protein denotes GATA-3
T16794 3649-3656 Entity denotes nuclear
T16795 3657-3663 Localization denotes import
T16796 3776-3785 Regulation denotes dependent
T16797 3786-3795 Positive_regulation denotes induction
T16798 3802-3811 Positive_regulation denotes activated
T16799 3812-3814 Protein denotes GR
T16800 3815-3826 Binding denotes interaction
T16801 3875-3877 Protein denotes GR
T16802 3878-3889 Binding denotes association
T16803 4199-4208 Regulation denotes dependent
T16804 4209-4218 Positive_regulation denotes induction
T16805 4225-4234 Positive_regulation denotes activated
T16806 4235-4237 Protein denotes GR
T16807 4238-4245 Entity denotes nuclear
T16808 4246-4259 Localization denotes translocation
T16809 4556-4565 Regulation denotes dependent
T16810 4566-4574 Negative_regulation denotes decrease
T16811 4578-4584 Protein denotes GATA-3
T16812 4596-4607 Binding denotes association
T16813 4846-4852 Protein denotes GATA-3
T16814 4857-4870 Gene_expression denotes overexpressed
T19273 11649-11656 Negative_regulation denotes impairs
T19274 11649-11656 Negative_regulation denotes impairs
T19275 11657-11663 Protein denotes GATA-3
T19276 11664-11675 Binding denotes interaction
T19277 11696-11702 Protein denotes GATA-3
T19278 11703-11710 Entity denotes nuclear
T19279 11711-11723 Localization denotes localization
T19280 11869-11877 Negative_regulation denotes impaired
T19281 11878-11889 Binding denotes interaction
T19282 11898-11904 Protein denotes GATA-3
T19283 12249-12258 Negative_regulation denotes decreased
T19284 12259-12270 Binding denotes association
T19285 12279-12285 Protein denotes GATA-3
R7090 T8205 T8202 themeOf translocation,resulted
R7091 T8209 T8208 themeOf loss,caused
R7092 T8210 T8212 locationOf nuclear,expression
R7093 T8211 T8212 themeOf GATA-3,expression
R7094 T8212 T8209 themeOf expression,loss
R7095 T8213 T8214 locationOf cytoplasmic,retention
R7096 T8214 T8207 themeOf retention,caused
R7097 T8215 T8214 themeOf GATA-3,retention
R7098 T8216 T8221 themeOf This effect,dependent
R7099 T8217 T8220 themeOf This effect,dependent
R7100 T8218 T8219 themeOf This effect,dependent
R7101 T8222 T8217 themeOf associated,This effect
R7102 T8223 T8218 themeOf associated,This effect
R7103 T8224 T8216 themeOf associated,This effect
R7104 T8225 T8224 themeOf reductions,associated
R7105 T8226 T8222 themeOf reductions,associated
R7106 T8227 T8225 themeOf stimulated,reductions
R7107 T8228 T8226 themeOf stimulated,reductions
R7108 T8229 T8232 themeOf IL-4,mRNA expression
R7109 T8230 T8231 themeOf IL-5,mRNA expression
R7110 T8231 T8228 themeOf mRNA expression,stimulated
R7111 T8232 T8227 themeOf mRNA expression,stimulated
R7112 T8233 T8223 themeOf loss,associated
R7113 T8234 T8235 themeOf GATA-3,binding
R7114 T8235 T8233 themeOf binding,loss
R7115 T8237 T8235 themeOf promoter,binding
R7116 T8237 T8236 partOf promoter,IL-5
R7695 T8930 T8932 themeOf association,induced
R7696 T8931 T8930 themeOf GATA-3,association
R7697 T8935 T8937 themeOf GATA-3,import
R7698 T8936 T8937 locationOf nuclear,import
R7699 T8937 T8938 themeOf import,following
R7700 T8937 T8939 themeOf import,attenuated
R8282 T9651 T9652 locationOf nuclear,import
R8283 T9652 T9649 themeOf import,limit
R8284 T9655 T9657 themeOf GATA-3,export
R8285 T9655 T9658 themeOf GATA-3,degradation
R8286 T9656 T9657 locationOf nuclear,export
R8287 T9657 T9653 themeOf export,effect
R8288 T9658 T9654 themeOf degradation,effect
R8289 T9660 T9659 themeOf block,affect
R8290 T9661 T9663 themeOf GATA-3,localization
R8291 T9662 T9663 locationOf nuclear,localization
R8292 T9663 T9660 themeOf localization,block
R8293 T9665 T9666 themeOf GATA-3,expression
R8294 T9666 T9664 themeOf expression,effect
R8295 T9668 T9670 themeOf GATA-3,residency
R8296 T9669 T9670 locationOf nuclear,residency
R8297 T9670 T9667 themeOf residency,affect
R8298 T9672 T9671 themeOf GR,activated
R8299 T9672 T9673 causeOf GR,enhance
R8300 T9674 T9676 themeOf GATA-3,export
R8301 T9675 T9676 locationOf nuclear,export
R8302 T9676 T9673 themeOf export,enhance
R8303 T9678 T9680 themeOf GATA-3,import
R8304 T9679 T9680 locationOf nuclear,import
R8305 T9680 T9677 themeOf import,effect
R8306 T9682 T9684 themeOf p65,translocation
R8307 T9683 T9684 locationOf nuclear,translocation
R8308 T9684 T9681 themeOf translocation,effect
R9623 T11262 T11263 locationOf nuclear,translocation
R9624 T11263 T11260 themeOf translocation,increased
R9625 T11266 T11265 themeOf loss,induced
R9626 T11267 T11266 locationOf nuclear,loss
R9627 T11268 T11266 themeOf GATA-3,loss
R9628 T11269 T11271 locationOf cytoplasmic,levels
R9629 T11270 T11271 themeOf GATA-3,levels
R9630 T11271 T11272 themeOf levels,enhanced
R9631 T11272 T11273 themeOf enhanced,dependent
R9632 T11275 T11276 locationOf nuclear,localization
R9633 T11276 T11274 themeOf localization,reduces
R9634 T11277 T11276 themeOf GATA-3,localization
R9635 T11278 T11274 causeOf inhibiting,reduces
R9636 T11279 T11280 themeOf GATA-3,association
R9637 T11280 T11278 themeOf association,inhibiting
R9638 T11282 T11283 themeOf GATA-3,phosphorylation
R9639 T11283 T11281 themeOf phosphorylation,mediated
R9640 T11285 T11284 themeOf MKP-1,induction
R9641 T11287 T11286 themeOf suppression,effects
R9642 T11288 T11290 themeOf GATA-3,import
R9643 T11289 T11290 locationOf nuclear,import
R9644 T11290 T11287 themeOf import,suppression
R15079 T17584 T17583 themeOf down-regulation,associated
R15080 T17586 T17587 themeOf serine,phosphorylation
R15081 T17586 T17585 partOf serine,GATA-3
R15082 T17587 T17584 themeOf phosphorylation,down-regulation
R15083 T17589 T17588 themeOf phosphorylation,effect
R15084 T17590 T17589 themeOf activated transcription factor 2,phosphorylation
R15085 T17591 T17590 equivalentTo ATF-2,activated transcription factor 2
R15086 T17594 T17596 partOf serine,GATA-3
R15087 T17594 T17595 themeOf serine,phosphorylation
R15088 T17595 T17593 themeOf phosphorylation,induced
R15089 T17595 T17592 themeOf phosphorylation,decrease
R15090 T17597 T17599 themeOf induced,dependent
R15091 T17598 T17597 themeOf MKP-1,induced
R15092 T17600 T17602 themeOf induces,dependent
R15093 T17601 T17600 themeOf MKP-1,induces
R15645 T18279 T18278 themeOf GATA-3,phospho
R15646 T18280 T18281 causeOf GR,enhances
R15647 T18282 T18283 themeOf GR,binding
R15648 T18283 T18281 themeOf binding,enhances
R15649 T18286 T18285 themeOf GR,activated
R15650 T18287 T18288 causeOf GATA-3,attenuate
R15651 T18289 T18290 themeOf GR,association
R15652 T18290 T18288 themeOf association,attenuate
R15653 T18292 T18293 causeOf GR,blocks
R15654 T18292 T18291 themeOf GR,Activated
R15655 T18295 T18296 themeOf GATA-3,interacting
R15656 T18295 T18294 themeOf GATA-3,phospho
R15657 T18296 T18293 themeOf interacting,blocks
R15658 T18299 T18300 themeOf GATA-3,binding
R15659 T18300 T18298 themeOf binding,stimulated
R15660 T18303 T18301 themeOf GR,activated
R15661 T18303 T18302 themeOf GR,unstimulated
R15662 T18303 T18304 causeOf GR,attenuation
R15663 T18304 T18307 themeOf attenuation,dependent
R15664 T18305 T18306 themeOf GATA-3,association
R15665 T18306 T18304 themeOf association,attenuation
R15967 T18703 T18699 themeOf localization,prevent
R15968 T18703 T18700 themeOf localization,stimulated
R15969 T18705 T18706 themeOf GATA-3,degradation
R15970 T18706 T18704 themeOf degradation,affect
R15971 T18710 T18712 themeOf p65,translocation
R15972 T18711 T18712 locationOf nuclear,translocation
R15973 T18712 T18708 themeOf translocation,prevent
R15974 T18712 T18709 themeOf translocation,stimulated
R16816 T19699 T19701 themeOf GATA-3,localization
R16817 T19700 T19701 locationOf nuclear,localization
R16818 T19701 T19698 themeOf localization,impairs
R16819 T19702 T19705 themeOf GR,localisation
R16820 T19703 T19706 themeOf GATA-3,localisation
R16821 T19704 T19705 locationOf nuclear,localisation
R16822 T19704 T19706 locationOf nuclear,localisation
R16823 T19710 T19708 themeOf decrease,dependent
R16824 T19711 T19712 locationOf nuclear,expression
R16825 T19712 T19710 themeOf expression,decrease
R16826 T19713 T19712 themeOf GATA-3,expression
R16827 T19714 T19709 themeOf increased,dependent
R16828 T19715 T19717 locationOf cytoplasmic,expression
R16829 T19716 T19717 themeOf GATA-3,expression
R16830 T19717 T19714 themeOf expression,increased
R16831 T19719 T19720 locationOf nuclear,expression
R16832 T19720 T19718 themeOf expression,decrease
R16833 T19721 T19720 themeOf GATA-3,expression
R16834 T19722 T19724 locationOf cytoplasmic,expression
R16835 T19723 T19724 themeOf GATA-3,expression
R13739 T16003 T16000 themeOf import,inhibits
R13737 T16001 T16003 themeOf GATA-3,import
R13738 T16002 T16003 locationOf nuclear,import
R13740 T16005 T16004 themeOf GATA-3,translocation
R13741 T16006 T16004 locationOf nucleus,translocation
R13742 T16008 T16009 locationOf nuclear,localization
R13743 T16009 T16011 themeOf localization,induced
R13744 T16010 T16009 themeOf GATA-3,localization
R13745 T16015 T16017 themeOf IL-4,mRNA expression
R13746 T16016 T16018 themeOf IL-5,mRNA expression
R13747 T16017 T16014 themeOf mRNA expression,inhibits
R13748 T16018 T16013 themeOf mRNA expression,inhibits
R13749 T16019 T16022 themeOf CD3,costimulated
R13750 T16020 T16021 themeOf CD28,costimulated
R13751 T16025 T16026 themeOf GATA-3,associate
R13752 T16025 T16024 themeOf GATA-3,stimulated
R13753 T16026 T16023 themeOf associate,reduces
R13754 T16028 T16026 themeOf promoter,associate
R13755 T16028 T16027 partOf promoter,IL-5
R7075 T8187 T8189 themeOf GATA-3,Translocation
R7076 T8188 T8189 locationOf Nuclear,Translocation
R7077 T8189 T8185 themeOf Translocation,Effect
R7078 T8190 T8186 themeOf IL-4,Effect
R7079 T8192 T8191 themeOf inhibiting,effective
R7080 T8193 T8194 causeOf GATA-3,regulated
R7081 T8194 T8192 themeOf regulated,inhibiting
R7082 T8195 T8196 themeOf IL-4,expression
R7083 T8196 T8194 themeOf expression,regulated
R7084 T8198 T8197 themeOf stimulated,affect
R7085 T8199 T8200 locationOf nuclear,import
R7086 T8200 T8198 themeOf import,stimulated
R7087 T8201 T8200 themeOf GATA-3,import
R7088 T8203 T8205 locationOf nuclear,translocation
R7089 T8204 T8205 themeOf GATA-3,translocation
R15962 T18696 T18697 themeOf GATA-3,export
R15963 T18697 T18695 themeOf export,affect
R15964 T18699 T18698 themeOf prevent,affect
R15965 T18701 T18703 themeOf GATA-3,localization
R15966 T18702 T18703 locationOf nuclear,localization
R9596 T11225 T11227 themeOf GATA-3,Localization
R9597 T11226 T11227 locationOf Nuclear,Localization
R9598 T11227 T11224 themeOf Localization,Inhibitory
R9599 T11229 T11228 themeOf decrease,dependent
R9600 T11230 T11229 themeOf interaction,decrease
R9601 T11230 T11233 themeOf interaction,inhibited
R9602 T11230 T11234 themeOf interaction,attenuated
R9603 T11232 T11230 themeOf GATA-3,interaction
R9604 T11232 T11231 themeOf GATA-3,phospho
R9605 T11237 T11240 themeOf IL-4,expression
R9606 T11238 T11239 themeOf -5,expression
R9607 T11239 T11235 themeOf expression,suppresses
R9608 T11240 T11236 themeOf expression,suppresses
R9609 T11242 T11241 themeOf interaction,attenuated
R9610 T11243 T11242 themeOf GATA-3,interaction
R9611 T11244 T11247 themeOf reduced,dependent
R9612 T11245 T11246 themeOf GATA-3,interaction
R9613 T11246 T11244 themeOf interaction,reduced
R9614 T11249 T11248 themeOf decrease,produced
R9615 T11250 T11251 themeOf GATA-3,association
R9616 T11251 T11249 themeOf association,decrease
R9617 T11252 T11253 themeOf GATA-3,association
R9618 T11255 T11254 themeOf interaction,attenuated
R9619 T11256 T11255 themeOf GATA-3,interaction
R9620 T11258 T11257 themeOf localization,affect
R9621 T11259 T11258 themeOf GATA-3,localization
R9622 T11261 T11263 themeOf GR,translocation
R7683 T8915 T8916 themeOf GATA-3,for
R7684 T8918 T8917 themeOf GR,activated
R7685 T8918 T8924 themeOf GR,import
R7686 T8919 T8923 themeOf GATA-3,import
R7687 T8922 T8924 locationOf nuclear,import
R7688 T8922 T8923 locationOf nuclear,import
R7689 T8923 T8920 themeOf import,uses
R7690 T8924 T8921 themeOf import,uses
R7691 T8926 T8928 themeOf GR,translocation
R7692 T8927 T8928 locationOf nuclear,translocation
R7693 T8929 T8933 themeOf decreased,dependent
R7694 T8930 T8929 themeOf association,decreased
R8230 T9585 T9584 themeOf MKP-1,induction
R8231 T9586 T9585 equivalentTo MAPK phosphatase-1,MKP-1
R8232 T9588 T9587 themeOf phosphorylation,decreased
R8235 T9591 T9596 themeOf reduced,dependent
R8240 T9598 T9599 themeOf GATA-3,phosphorylation
R8241 T9599 T9597 themeOf phosphorylation,This reduction
R8242 T9600 T9603 themeOf induced,dependent
R8243 T9601 T9602 themeOf MKP-1,mRNA
R8244 T9602 T9600 themeOf mRNA,induced
R8245 T9607 T9609 themeOf GATA-3,import
R8246 T9607 T9610 themeOf GATA-3,association
R8247 T9608 T9609 locationOf nuclear,import
R8248 T9609 T9606 themeOf import,effects
R8249 T9610 T9604 themeOf association,effects
R8250 T9611 T9612 themeOf IL-4,mRNA expression
R8251 T9612 T9605 themeOf mRNA expression,effects
R8252 T9616 T9613 themeOf GATA-3,competition
R8253 T9616 T9615 themeOf GATA-3,activated
R8254 T9618 T9614 themeOf GR,competition
R8255 T9618 T9617 themeOf GR,activated
R8256 T9620 T9619 themeOf GR,activated
R8257 T9620 T9621 causeOf GR,increased
R8258 T9621 T9624 themeOf increased,in the presence and absence of
R8259 T9622 T9623 themeOf GR,association
R8260 T9623 T9621 themeOf association,increased
R8261 T9625 T9624 causeOf activated,in the presence and absence of
R8262 T9626 T9625 themeOf GATA-3,activated
R8263 T9628 T9627 themeOf GATA-3,activated
R8264 T9628 T9629 causeOf GATA-3,block
R8265 T9630 T9631 themeOf GR,association
R8266 T9631 T9629 themeOf association,block
R8267 T9633 T9632 themeOf GR,activated
R8268 T9633 T9635 themeOf GR,associate
R8233 T9590 T9588 themeOf ATF-2,phosphorylation
R8234 T9590 T9589 themeOf ATF-2,target
R8236 T9593 T9594 themeOf serine,phosphorylation
R8237 T9593 T9592 partOf serine,GATA-3
R8238 T9594 T9591 themeOf phosphorylation,reduced
R8239 T9594 T9595 themeOf phosphorylation,induced
R8269 T9634 T9636 themeOf GATA-3,associate
R8270 T9638 T9637 themeOf GR,activated
R8271 T9638 T9639 causeOf GR,attenuates
R8272 T9639 T9643 themeOf attenuates,dependent
R8273 T9641 T9642 themeOf GATA-3,interaction
R8274 T9641 T9640 themeOf GATA-3,phospho
R8275 T9642 T9639 themeOf interaction,attenuates
R8276 T9645 T9644 themeOf GR,activated
R8277 T9645 T9646 causeOf GR,compete
R8278 T9646 T9649 causeOf compete,limit
R8279 T9647 T9648 themeOf GATA-3,for
R8280 T9648 T9646 themeOf for,compete
R8281 T9650 T9652 themeOf GATA-3,import
R14391 T16791 T16792 themeOf GATA-3,association
R14392 T16792 T16789 themeOf association,reduces
R14393 T16793 T16795 themeOf GATA-3,import
R14394 T16794 T16795 locationOf nuclear,import
R14395 T16795 T16790 themeOf import,reduces
R14396 T16797 T16796 themeOf induction,dependent
R14397 T16799 T16800 themeOf GR,interaction
R14398 T16799 T16798 themeOf GR,activated
R14399 T16800 T16797 themeOf interaction,induction
R14400 T16801 T16802 themeOf GR,association
R14401 T16804 T16803 themeOf induction,dependent
R14402 T16806 T16808 themeOf GR,translocation
R14403 T16806 T16805 themeOf GR,activated
R14404 T16807 T16808 locationOf nuclear,translocation
R14405 T16808 T16804 themeOf translocation,induction
R14406 T16810 T16809 themeOf decrease,dependent
R14407 T16811 T16812 themeOf GATA-3,association
R14408 T16812 T16810 themeOf association,decrease
R14409 T16813 T16814 themeOf GATA-3,overexpressed
R16449 T19275 T19276 themeOf GATA-3,interaction
R16450 T19276 T19273 themeOf interaction,impairs
R16451 T19277 T19279 themeOf GATA-3,localization
R16452 T19278 T19279 locationOf nuclear,localization
R16453 T19279 T19274 themeOf localization,impairs
R16454 T19281 T19280 themeOf interaction,impaired
R16455 T19282 T19281 themeOf GATA-3,interaction
R16456 T19284 T19283 themeOf association,decreased
R16457 T19285 T19284 themeOf GATA-3,association

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T8423 42-48 P23771 denotes GATA-3
T8424 75-79 P05112 denotes IL-4
T8425 129-135 P23771 denotes GATA-3
T8426 146-150 P05112 denotes IL-4
T8427 256-259 P04234 denotes CD3
T8428 256-259 P20963 denotes CD3
T8429 256-259 P07766 denotes CD3
T8430 256-259 P09693 denotes CD3
T8431 260-264 P10747 denotes CD28
T8432 294-300 P23771 denotes GATA-3
T8433 333-336 P04234 denotes CD3
T8434 333-336 P20963 denotes CD3
T8435 333-336 P07766 denotes CD3
T8436 333-336 P09693 denotes CD3
T8437 337-341 P10747 denotes CD28
T8438 382-388 P23771 denotes GATA-3
T8439 557-562 Q02750 denotes MEK-1
T8440 654-660 P23771 denotes GATA-3
T8441 701-707 P23771 denotes GATA-3
T8442 980-983 P20963 denotes CD3
T8443 980-983 P09693 denotes CD3
T8444 980-983 P07766 denotes CD3
T8445 980-983 P04234 denotes CD3
T8446 984-988 P10747 denotes CD28
T8447 1000-1004 P05112 denotes IL-4
T8448 1009-1013 P05113 denotes IL-5
T8449 1056-1062 P23771 denotes GATA-3
T8450 1085-1089 P05113 denotes IL-5
T9089 2678-2680 P04150 denotes GR
T9090 2695-2701 P23771 denotes GATA-3
T9091 2792-2794 P04150 denotes GR
T9092 2806-2812 P23771 denotes GATA-3
T9093 2897-2899 P04150 denotes GR
T9094 3010-3012 P04150 denotes GR
T9095 3206-3212 P23771 denotes GATA-3
T9096 3244-3247 P09693 denotes CD3
T9097 3244-3247 P20963 denotes CD3
T9098 3244-3247 P07766 denotes CD3
T9099 3244-3247 P04234 denotes CD3
T9100 3248-3252 P10747 denotes CD28
T9101 3333-3336 Q9U6Y4 denotes GFP
T9102 3346-3352 P23771 denotes GATA-3
T9103 3398-3404 P23771 denotes GATA-3
T9104 3435-3438 P09693 denotes CD3
T9105 3435-3438 P07766 denotes CD3
T9106 3435-3438 P04234 denotes CD3
T9107 3435-3438 P20963 denotes CD3
T9108 3439-3443 P10747 denotes CD28
T10140 5098-5103 P28562 denotes MKP-1
T10141 5127-5130 Q15759 denotes p38
T10142 5127-5130 P53778 denotes p38
T10143 5127-5130 O15264 denotes p38
T10144 5127-5130 Q16539 denotes p38
T10145 5235-5240 P28562 denotes MKP-1
T10146 5362-5365 P09693 denotes CD3
T10147 5362-5365 P07766 denotes CD3
T10148 5362-5365 P20963 denotes CD3
T10149 5362-5365 P04234 denotes CD3
T10150 5366-5370 P10747 denotes CD28
T10151 5404-5407 O15264 denotes p38
T10152 5404-5407 Q16539 denotes p38
T10153 5404-5407 Q15759 denotes p38
T10154 5404-5407 P53778 denotes p38
T10155 5507-5512 P15336 denotes ATF-2
T10156 5642-5648 P23771 denotes GATA-3
T10157 5688-5691 P09693 denotes CD3
T10158 5688-5691 P04234 denotes CD3
T10159 5688-5691 P07766 denotes CD3
T10160 5688-5691 P20963 denotes CD3
T10161 5692-5696 P10747 denotes CD28
T10162 5791-5797 P23771 denotes GATA-3
T10163 5900-5905 P28562 denotes MKP-1
T10164 6055-6061 P23771 denotes GATA-3
T10165 6105-6109 P05112 denotes IL-4
T10166 7582-7588 P23771 denotes GATA-3
T10167 7616-7618 P04150 denotes GR
T10168 7651-7653 P04150 denotes GR
T10169 7678-7680 P04150 denotes GR
T10170 7745-7751 P23771 denotes GATA-3
T10171 7808-7814 P23771 denotes GATA-3
T10172 7829-7831 P04150 denotes GR
T10173 7912-7914 P04150 denotes GR
T10174 7927-7933 P23771 denotes GATA-3
T10175 8004-8006 P04150 denotes GR
T10176 8030-8036 P23771 denotes GATA-3
T10177 8155-8157 P04150 denotes GR
T10178 8183-8189 P23771 denotes GATA-3
T10179 8223-8229 P23771 denotes GATA-3
T10180 9413-9419 P23771 denotes GATA-3
T10181 9542-9548 P23771 denotes GATA-3
T10182 9628-9634 P23771 denotes GATA-3
T10183 9745-9748 P20963 denotes CD3
T10184 9745-9748 P09693 denotes CD3
T10185 9745-9748 P07766 denotes CD3
T10186 9745-9748 P04234 denotes CD3
T10187 9749-9753 P10747 denotes CD28
T10188 9783-9789 P23771 denotes GATA-3
T10189 9847-9849 P04150 denotes GR
T10190 9867-9873 P23771 denotes GATA-3
T10191 9919-9925 P23771 denotes GATA-3
T10192 9997-10000 Q04206 denotes p65
T10193 9997-10000 P21579 denotes p65
T11896 11150-11156 P23771 denotes GATA-3
T11897 11339-11345 P23771 denotes GATA-3
T11898 12601-12605 P05112 denotes IL-4
T11899 12663-12669 P23771 denotes GATA-3
T11900 12923-12929 P23771 denotes GATA-3
T11901 13022-13028 P23771 denotes GATA-3
T11902 13320-13326 P23771 denotes GATA-3
T11903 13462-13468 P23771 denotes GATA-3
T11904 13716-13722 P23771 denotes GATA-3
T11905 13819-13821 P04150 denotes GR
T11906 13906-13912 P23771 denotes GATA-3
T11907 14297-14303 P23771 denotes GATA-3
T11908 14440-14446 P23771 denotes GATA-3
T11909 14668-14671 O15264 denotes p38
T11910 14668-14671 Q16539 denotes p38
T11911 14668-14671 Q15759 denotes p38
T11912 14668-14671 P53778 denotes p38
T11913 16336-16342 P23771 denotes GATA-3
T11914 16381-16387 P23771 denotes GATA-3
T11915 16526-16529 Q16539 denotes p38
T11916 16526-16529 P53778 denotes p38
T11917 16526-16529 Q15759 denotes p38
T11918 16526-16529 O15264 denotes p38
T11919 16544-16550 P23771 denotes GATA-3
T11920 16590-16595 P28562 denotes MKP-1
T11921 16684-16690 P23771 denotes GATA-3
T16280 1236-1242 P23771 denotes GATA-3
T16281 1268-1271 P09693 denotes CD3
T16282 1268-1271 P20963 denotes CD3
T16283 1268-1271 P04234 denotes CD3
T16284 1268-1271 P07766 denotes CD3
T16285 1272-1276 P10747 denotes CD28
T16286 1331-1337 P23771 denotes GATA-3
T16287 1406-1411 Q02750 denotes MEK-1
T16288 1619-1625 P23771 denotes GATA-3
T16289 1642-1645 P04234 denotes CD3
T16290 1642-1645 P20963 denotes CD3
T16291 1642-1645 P07766 denotes CD3
T16292 1642-1645 P09693 denotes CD3
T16293 1646-1650 P10747 denotes CD28
T16294 1822-1826 Q02750 denotes MEK1
T16295 2081-2085 P05112 denotes IL-4
T16296 2090-2094 P05113 denotes IL-5
T16297 2114-2117 P09693 denotes CD3
T16298 2114-2117 P04234 denotes CD3
T16299 2114-2117 P07766 denotes CD3
T16300 2114-2117 P20963 denotes CD3
T16301 2118-2122 P10747 denotes CD28
T16302 2143-2148 P04406 denotes GAPDH
T16303 2354-2357 P04234 denotes CD3
T16304 2354-2357 P20963 denotes CD3
T16305 2354-2357 P07766 denotes CD3
T16306 2354-2357 P09693 denotes CD3
T16307 2358-2362 P10747 denotes CD28
T16308 2418-2421 P09693 denotes CD3
T16309 2418-2421 P20963 denotes CD3
T16310 2418-2421 P04234 denotes CD3
T16311 2418-2421 P07766 denotes CD3
T16312 2422-2426 P10747 denotes CD28
T16313 2438-2444 P23771 denotes GATA-3
T16314 2474-2478 P05113 denotes IL-5
T17086 3603-3609 P23771 denotes GATA-3
T17087 3642-3648 P23771 denotes GATA-3
T17088 3812-3814 P04150 denotes GR
T17089 3875-3877 P04150 denotes GR
T17090 4235-4237 P04150 denotes GR
T17091 4503-4506 P04234 denotes CD3
T17092 4503-4506 P07766 denotes CD3
T17093 4503-4506 P20963 denotes CD3
T17094 4503-4506 P09693 denotes CD3
T17095 4507-4511 P10747 denotes CD28
T17096 4578-4584 P23771 denotes GATA-3
T17097 4808-4812 P10747 denotes CD28
T17098 4835-4838 Q9U6Y4 denotes GFP
T17099 4846-4852 P23771 denotes GATA-3
T17100 4931-4934 P07766 denotes CD3
T17101 4931-4934 P20963 denotes CD3
T17102 4931-4934 P04234 denotes CD3
T17103 4931-4934 P09693 denotes CD3
T17104 4935-4939 P10747 denotes CD28
T17820 6286-6289 Q15759 denotes p38
T17821 6286-6289 Q16539 denotes p38
T17822 6286-6289 O15264 denotes p38
T17823 6286-6289 P53778 denotes p38
T17824 6379-6385 P23771 denotes GATA-3
T17825 6542-6545 Q16539 denotes p38
T17826 6542-6545 Q15759 denotes p38
T17827 6542-6545 P53778 denotes p38
T17828 6542-6545 O15264 denotes p38
T17829 6559-6562 P04234 denotes CD3
T17830 6559-6562 P09693 denotes CD3
T17831 6559-6562 P07766 denotes CD3
T17832 6559-6562 P20963 denotes CD3
T17833 6563-6567 P10747 denotes CD28
T17834 6663-6695 P15336 denotes activated transcription factor 2
T17835 6697-6702 P15336 denotes ATF-2
T17836 6718-6721 Q16539 denotes p38
T17837 6718-6721 Q15759 denotes p38
T17838 6718-6721 O15264 denotes p38
T17839 6718-6721 P53778 denotes p38
T17840 6766-6769 P53778 denotes p38
T17841 6766-6769 Q16539 denotes p38
T17842 6766-6769 Q15759 denotes p38
T17843 6766-6769 O15264 denotes p38
T17844 6824-6827 P09693 denotes CD3
T17845 6824-6827 P20963 denotes CD3
T17846 6824-6827 P04234 denotes CD3
T17847 6824-6827 P07766 denotes CD3
T17848 6828-6832 P10747 denotes CD28
T17849 6890-6896 P23771 denotes GATA-3
T17850 4808-4812 P10747 denotes CD28
T17851 7135-7140 P28562 denotes MKP-1
T17852 7326-7331 P28562 denotes MKP-1
T18311 8335-8341 P23771 denotes GATA-3
T18312 8434-8436 P04150 denotes GR
T18313 8489-8491 P04150 denotes GR
T18314 8560-8566 P23771 denotes GATA-3
T18315 8602-8604 P04150 denotes GR
T18316 8610-8616 P23771 denotes GATA-3
T18317 8636-8639 P07766 denotes CD3
T18318 8636-8639 P20963 denotes CD3
T18319 8636-8639 P09693 denotes CD3
T18320 8636-8639 P04234 denotes CD3
T18321 8640-8644 P10747 denotes CD28
T18322 8681-8683 P04150 denotes GR
T18323 8751-8753 P04150 denotes GR
T18324 8793-8799 P23771 denotes GATA-3
T18325 8819-8822 P07766 denotes CD3
T18326 8819-8822 P04234 denotes CD3
T18327 8819-8822 P20963 denotes CD3
T18328 8819-8822 P09693 denotes CD3
T18329 8823-8827 P10747 denotes CD28
T18330 8935-8941 P23771 denotes GATA-3
T18331 9008-9014 P23771 denotes GATA-3
T18332 9089-9091 P04150 denotes GR
T18333 9110-9116 P23771 denotes GATA-3
T18898 10138-10144 P23771 denotes GATA-3
T18899 10308-10311 P09693 denotes CD3
T18900 10308-10311 P20963 denotes CD3
T18901 10308-10311 P07766 denotes CD3
T18902 10308-10311 P04234 denotes CD3
T18903 10312-10316 P10747 denotes CD28
T18904 10328-10334 P23771 denotes GATA-3
T18905 2354-2357 P20963 denotes CD3
T18906 2354-2357 P09693 denotes CD3
T18907 2354-2357 P07766 denotes CD3
T18908 2354-2357 P04234 denotes CD3
T18909 2358-2362 P10747 denotes CD28
T18910 10553-10559 P23771 denotes GATA-3
T18911 10587-10590 Q9U6Y4 denotes GFP
T18912 10598-10604 P23771 denotes GATA-3
T18913 10670-10673 P20963 denotes CD3
T18914 10670-10673 P07766 denotes CD3
T18915 10670-10673 P09693 denotes CD3
T18916 10670-10673 P04234 denotes CD3
T18917 10674-10678 P10747 denotes CD28
T18918 10766-10769 P07766 denotes CD3
T18919 10766-10769 P04234 denotes CD3
T18920 10766-10769 P20963 denotes CD3
T18921 10766-10769 P09693 denotes CD3
T18922 10770-10774 P10747 denotes CD28
T18923 10828-10831 P04234 denotes CD3
T18924 10828-10831 P09693 denotes CD3
T18925 10828-10831 P07766 denotes CD3
T18926 10828-10831 P20963 denotes CD3
T18927 10832-10836 P10747 denotes CD28
T18928 10848-10851 Q04206 denotes p65
T18929 10848-10851 P21579 denotes p65
T19426 11657-11663 P23771 denotes GATA-3
T19427 11696-11702 P23771 denotes GATA-3
T19428 11898-11904 P23771 denotes GATA-3
T19429 12279-12285 P23771 denotes GATA-3
T19970 14852-14858 P23771 denotes GATA-3
T19971 14977-14979 P04150 denotes GR
T19972 14984-14990 P23771 denotes GATA-3
T19973 15025-15031 P23771 denotes GATA-3
T19974 15421-15427 P23771 denotes GATA-3
T19975 15455-15461 P23771 denotes GATA-3
T19976 15598-15604 P23771 denotes GATA-3
T19977 15632-15638 P23771 denotes GATA-3
T19978 15693-15698 Q02750 denotes MEK-1
T19979 16133-16136 Q16539 denotes p38
T19980 16133-16136 Q15759 denotes p38
T19981 16133-16136 P53778 denotes p38
T19982 16133-16136 O15264 denotes p38

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T8147 13-19 Regulation denotes Effect
T8148 42-48 Protein denotes GATA-3
T8149 49-56 Entity denotes Nuclear
T8150 57-70 Localization denotes Translocation
T8151 75-79 Protein denotes IL-4
T8152 118-128 Negative_regulation denotes inhibiting
T8153 129-135 Protein denotes GATA-3
T8154 136-145 Regulation denotes regulated true
T8155 146-150 Protein denotes IL-4
T8156 156-166 Gene_expression denotes expression
T8157 244-250 Regulation denotes affect
T8158 265-275 Positive_regulation denotes stimulated
T8159 276-283 Entity denotes nuclear
T8160 284-290 Localization denotes import
T8161 294-300 Protein denotes GATA-3
T8162 342-350 Positive_regulation denotes resulted
T8163 374-381 Entity denotes nuclear
T8164 382-388 Protein denotes GATA-3
T8165 389-402 Localization denotes translocation
T8166 557-562 Protein denotes MEK-1
T8167 628-637 Positive_regulation denotes sustained
T8168 638-642 Negative_regulation denotes loss
T8169 646-653 Entity denotes nuclear
T8170 654-660 Protein denotes GATA-3
T8171 661-671 Gene_expression denotes expression
T8172 676-687 Entity denotes cytoplasmic
T8173 688-697 Localization denotes retention
T8174 701-707 Protein denotes GATA-3
T8175 961-971 Negative_regulation denotes reductions
T8176 989-999 Positive_regulation denotes stimulated
T8177 1000-1004 Protein denotes IL-4
T8178 1009-1013 Protein denotes IL-5
T8179 1014-1029 Transcription denotes mRNA expression
T8180 1048-1052 Negative_regulation denotes loss
T8181 1056-1062 Protein denotes GATA-3
T8182 1063-1070 Binding denotes binding
T8183 1085-1089 Protein denotes IL-5
T8184 1090-1098 Entity denotes promoter
T8891 2668-2677 Positive_regulation denotes Activated
T8892 2678-2680 Protein denotes GR
T8893 2695-2701 Protein denotes GATA-3
T8894 2782-2791 Positive_regulation denotes activated
T8895 2792-2794 Protein denotes GR
T8896 2806-2812 Protein denotes GATA-3
T8897 2837-2844 Entity denotes nuclear
T8898 2845-2851 Localization denotes import
T8899 2877-2888 Binding denotes interaction
T8900 2897-2899 Protein denotes GR
T8901 3010-3012 Protein denotes GR
T8902 3013-3020 Entity denotes nuclear
T8903 3021-3034 Localization denotes translocation
T8904 3172-3181 Negative_regulation denotes decreased
T8905 3186-3197 Binding denotes association
T8906 3206-3212 Protein denotes GATA-3
T8907 3228-3235 Positive_regulation denotes induced
T8908 3333-3352 Protein denotes GFP-labelled GATA-3
T8909 3398-3404 Protein denotes GATA-3
T8910 3405-3412 Entity denotes nuclear
T8911 3413-3419 Localization denotes import
T8912 3420-3429 Positive_regulation denotes following
T8913 3471-3481 Negative_regulation denotes attenuated
T9488 5088-5094 Regulation denotes Effect
T9489 5235-5240 Protein denotes MKP-1
T9490 5242-5260 Protein denotes MAPK phosphatase-1
T9491 5466-5481 Phosphorylation denotes phosphorylation
T9492 5507-5512 Protein denotes ATF-2
T9493 5634-5641 Negative_regulation denotes reduced
T9494 5642-5648 Protein denotes GATA-3
T9495 5649-5655 Entity denotes serine
T9496 5656-5671 Phosphorylation denotes phosphorylation
T9497 5672-5679 Positive_regulation denotes induced
T9498 5778-5787 Negative_regulation denotes reduction
T9499 5791-5797 Protein denotes GATA-3
T9500 5798-5813 Phosphorylation denotes phosphorylation
T9501 5892-5899 Positive_regulation denotes induced
T9502 5900-5905 Protein denotes MKP-1
T9503 6038-6045 Regulation denotes effects
T9504 6055-6061 Protein denotes GATA-3
T9505 6062-6069 Entity denotes nuclear
T9506 6070-6076 Localization denotes import
T9507 6089-6100 Binding denotes association
T9508 6105-6109 Protein denotes IL-4
T9509 6110-6125 Transcription denotes mRNA expression
T9510 7572-7581 Positive_regulation denotes activated
T9511 7582-7588 Protein denotes GATA-3
T9512 7606-7615 Positive_regulation denotes activated
T9513 7616-7618 Protein denotes GR
T9514 7641-7650 Positive_regulation denotes activated true
T9515 7651-7653 Protein denotes GR
T9516 7668-7677 Positive_regulation denotes increased
T9517 7678-7680 Protein denotes GR true
T9518 7692-7703 Binding denotes association
T9519 7724-7731 Negative_regulation denotes absence
T9520 7735-7744 Positive_regulation denotes activated
T9521 7745-7751 Protein denotes GATA-3
T9522 7798-7807 Positive_regulation denotes activated
T9523 7808-7814 Protein denotes GATA-3
T9524 7823-7828 Negative_regulation denotes block
T9525 7829-7831 Protein denotes GR
T9526 7843-7854 Binding denotes association
T9527 7902-7911 Positive_regulation denotes activated
T9528 7912-7914 Protein denotes GR true
T9529 7919-7926 Phosphorylation denotes phospho
T9530 7927-7933 Protein denotes GATA-3
T9531 7947-7956 Binding denotes associate
T9532 7994-8003 Positive_regulation denotes activated
T9533 8004-8006 Protein denotes GR
T9534 8007-8017 Negative_regulation denotes attenuates
T9535 8022-8029 Phosphorylation denotes phospho
T9536 8030-8036 Protein denotes GATA-3 true
T9537 8048-8059 Binding denotes interaction
T9538 8079-8088 Regulation denotes dependent
T9539 8145-8154 Positive_regulation denotes activated true
T9540 8155-8157 Protein denotes GR
T9541 8162-8169 Negative_regulation denotes compete true
T9542 8175-8182 Phosphorylation denotes phospho
T9543 8183-8189 Protein denotes GATA-3
T9544 8217-8222 Negative_regulation denotes limit true
T9545 8223-8229 Protein denotes GATA-3
T9546 8230-8237 Entity denotes nuclear
T9547 8238-8244 Localization denotes import
T9548 9397-9403 Regulation denotes effect true
T9549 9413-9419 Protein denotes GATA-3
T9550 9420-9427 Entity denotes nuclear
T9551 9428-9434 Localization denotes export
T9552 9442-9453 Protein_catabolism denotes degradation
T9553 9475-9483 Negative_regulation denotes inhibits
T9554 9492-9498 Localization denotes export
T9555 9508-9514 Regulation denotes affect
T9556 9536-9541 Negative_regulation denotes block
T9557 9542-9548 Protein denotes GATA-3
T9558 9549-9556 Entity denotes nuclear
T9559 9557-9569 Localization denotes localization
T9560 9607-9613 Regulation denotes effect
T9561 9628-9634 Protein denotes GATA-3
T9562 9635-9645 Gene_expression denotes expression
T9563 9754-9761 Entity denotes nuclear
T9564 9762-9775 Localization denotes translocation
T9565 9776-9782 Regulation denotes affect
T9566 9783-9789 Protein denotes GATA-3
T9567 9790-9797 Entity denotes nuclear
T9568 9798-9807 Localization denotes residency
T9569 9837-9846 Positive_regulation denotes activated
T9570 9847-9849 Protein denotes GR
T9571 9859-9866 Positive_regulation denotes enhance
T9572 9867-9873 Protein denotes GATA-3
T9573 9874-9881 Entity denotes nuclear
T9574 9882-9888 Localization denotes export
T9575 9903-9909 Regulation denotes effect
T9576 9919-9925 Protein denotes GATA-3
T9577 9926-9933 Entity denotes nuclear
T9578 9934-9940 Localization denotes import
T9579 9987-9993 Regulation denotes effect
T9580 9997-10000 Protein denotes p65
T9581 10001-10008 Entity denotes nuclear
T9582 10009-10022 Localization denotes translocation
T11160 11121-11127 Regulation denotes Effect
T11161 11150-11156 Protein denotes GATA-3
T11162 11157-11164 Entity denotes Nuclear
T11163 11165-11177 Localization denotes Localization
T11164 11278-11287 Regulation denotes dependent
T11165 11288-11296 Negative_regulation denotes decrease
T11166 11311-11322 Binding denotes interaction
T11167 11331-11338 Phosphorylation denotes phospho
T11168 11339-11345 Protein denotes GATA-3
T11169 11440-11449 Negative_regulation denotes inhibited
T11170 11518-11528 Negative_regulation denotes attenuated
T11171 12590-12600 Negative_regulation denotes suppresses
T11172 12601-12605 Protein denotes IL-4
T11173 12610-12612 Protein denotes -5
T11174 12618-12628 Gene_expression denotes expression
T11175 12633-12643 Negative_regulation denotes attenuated
T11176 12648-12659 Binding denotes interaction
T11177 12663-12669 Protein denotes GATA-3
T11178 12915-12922 Negative_regulation denotes reduced
T11179 12923-12929 Protein denotes GATA-3
T11180 12941-12952 Binding denotes interaction
T11181 12971-12980 Regulation denotes dependent
T11182 13010-13018 Negative_regulation denotes decrease
T11183 13022-13028 Protein denotes GATA-3 true
T11184 13040-13051 Binding denotes association
T11185 13320-13326 Protein denotes GATA-3
T11186 13338-13349 Binding denotes association
T11187 13436-13446 Negative_regulation denotes attenuated
T11188 13447-13458 Binding denotes interaction true
T11189 13462-13468 Protein denotes GATA-3
T11190 13545-13553 Negative_regulation denotes decrease
T11191 13684-13690 Regulation denotes affect
T11192 13700-13712 Localization denotes localization
T11193 13716-13722 Protein denotes GATA-3
T11194 13809-13818 Positive_regulation denotes increased
T11195 13819-13821 Protein denotes GR
T11196 13822-13829 Entity denotes nuclear
T11197 13830-13843 Localization denotes translocation
T11198 13906-13912 Protein denotes GATA-3
T11199 14261-14268 Positive_regulation denotes induced
T11200 14281-14285 Negative_regulation denotes loss
T11201 14297-14303 Protein denotes GATA-3
T11202 14440-14446 Protein denotes GATA-3
T11203 14459-14467 Positive_regulation denotes enhanced
T11204 16304-16311 Negative_regulation denotes reduces
T11205 16312-16319 Entity denotes nuclear
T11206 16320-16332 Localization denotes localization
T11207 16336-16342 Protein denotes GATA-3
T11208 16362-16372 Negative_regulation denotes inhibiting
T11209 16373-16380 Phosphorylation denotes phospho
T11210 16381-16387 Protein denotes GATA-3
T11211 16397-16408 Binding denotes association
T11212 16516-16522 Regulation denotes effect
T11213 16535-16543 Positive_regulation denotes mediated
T11214 16544-16550 Protein denotes GATA-3
T11215 16551-16566 Phosphorylation denotes phosphorylation
T11216 16577-16586 Positive_regulation denotes induction
T11217 16590-16595 Protein denotes MKP-1
T11218 16669-16680 Negative_regulation denotes suppression
T11219 16684-16690 Protein denotes GATA-3
T11220 16691-16698 Entity denotes nuclear
T11221 16699-16705 Localization denotes import
T15975 1227-1235 Negative_regulation denotes inhibits
T15976 1236-1242 Protein denotes GATA-3
T15977 1243-1250 Entity denotes nuclear
T15978 1251-1257 Localization denotes import
T15979 1314-1327 Localization denotes translocation
T15980 1331-1337 Protein denotes GATA-3
T15981 1364-1371 Entity denotes nucleus
T15982 1406-1411 Protein denotes MEK-1
T15983 1586-1594 Negative_regulation denotes impaired
T15984 1595-1602 Entity denotes nuclear
T15985 1603-1615 Localization denotes localization
T15986 1619-1625 Protein denotes GATA-3
T15987 1626-1633 Positive_regulation denotes induced
T15988 1822-1826 Protein denotes MEK1
T15989 2072-2080 Negative_regulation denotes inhibits
T15990 2081-2085 Protein denotes IL-4
T15991 2090-2094 Protein denotes IL-5
T15992 2095-2110 Transcription denotes mRNA expression
T15993 2114-2117 Protein denotes CD3
T15994 2118-2122 Protein denotes CD28
T15995 2390-2397 Negative_regulation denotes reduces
T15996 2427-2437 Positive_regulation denotes stimulated
T15997 2438-2444 Protein denotes GATA-3
T15998 2448-2457 Binding denotes associate
T15999 2474-2478 Protein denotes IL-5
T16765 3595-3602 Negative_regulation denotes reduces
T16766 3603-3609 Protein denotes GATA-3
T16767 3610-3621 Binding denotes association
T16768 3642-3648 Protein denotes GATA-3
T16769 3649-3656 Entity denotes nuclear
T16770 3657-3663 Localization denotes import
T16771 3776-3785 Regulation denotes dependent
T16772 3786-3795 Positive_regulation denotes induction
T16773 3802-3811 Positive_regulation denotes activated
T16774 3812-3814 Protein denotes GR
T16775 3815-3826 Binding denotes interaction
T16776 3875-3877 Protein denotes GR
T16777 3878-3889 Binding denotes association
T16778 4199-4208 Regulation denotes dependent
T16779 4209-4218 Positive_regulation denotes induction
T16780 4225-4234 Positive_regulation denotes activated
T16781 4235-4237 Protein denotes GR
T16782 4238-4245 Entity denotes nuclear
T16783 4246-4259 Localization denotes translocation
T16784 4556-4565 Regulation denotes dependent
T16785 4566-4574 Negative_regulation denotes decrease
T16786 4578-4584 Protein denotes GATA-3
T16787 4596-4607 Binding denotes association
T16788 4846-4852 Protein denotes GATA-3
T17567 6360-6375 Negative_regulation denotes down-regulation
T17568 6379-6385 Protein denotes GATA-3
T17569 6386-6392 Entity denotes serine
T17570 6393-6408 Phosphorylation denotes phosphorylation
T17571 6619-6625 Regulation denotes effect
T17572 6644-6659 Phosphorylation denotes phosphorylation
T17573 6663-6695 Protein denotes activated transcription factor 2
T17574 6697-6702 Protein denotes ATF-2
T17575 6848-6855 Positive_regulation denotes induced
T17576 6856-6862 Entity denotes serine
T17577 6863-6878 Phosphorylation denotes phosphorylation
T17578 6890-6896 Protein denotes GATA-3
T17579 7127-7134 Positive_regulation denotes induced
T17580 7135-7140 Protein denotes MKP-1
T17581 7318-7325 Positive_regulation denotes induces
T17582 7326-7331 Protein denotes MKP-1
T18248 8327-8334 Phosphorylation denotes phospho
T18249 8335-8341 Protein denotes GATA-3
T18250 8434-8436 Protein denotes GR
T18251 8480-8488 Positive_regulation denotes enhances
T18252 8489-8491 Protein denotes GR true
T18253 8503-8510 Binding denotes binding
T18254 8535-8542 Negative_regulation denotes absence
T18255 8550-8559 Positive_regulation denotes activated
T18256 8560-8566 Protein denotes GATA-3
T18257 8592-8601 Positive_regulation denotes activated
T18258 8602-8604 Protein denotes GR
T18259 8610-8616 Protein denotes GATA-3
T18260 8671-8680 Negative_regulation denotes attenuate
T18261 8681-8683 Protein denotes GR true
T18262 8695-8706 Binding denotes association
T18263 8741-8750 Positive_regulation denotes Activated
T18264 8751-8753 Protein denotes GR
T18265 8793-8799 Protein denotes GATA-3
T18266 8845-8856 Binding denotes interacting
T18267 8935-8941 Protein denotes GATA-3
T18268 8997-9007 Positive_regulation denotes stimulated
T18269 9008-9014 Protein denotes GATA-3
T18270 9024-9031 Binding denotes binding
T18271 9041-9047 Regulation denotes effect
T18272 9051-9060 Positive_regulation denotes activated
T18273 9089-9091 Protein denotes GR
T18274 9095-9106 Negative_regulation denotes attenuation
T18275 9110-9116 Protein denotes GATA-3
T18276 9128-9139 Binding denotes association
T18277 9158-9167 Regulation denotes dependent
T18676 10131-10137 Regulation denotes affect true
T18677 10138-10144 Protein denotes GATA-3
T18678 10145-10152 Entity denotes nuclear true
T18679 10153-10159 Localization denotes export
T18680 10258-10264 Regulation denotes affect
T18681 10295-10302 Negative_regulation denotes prevent
T18682 10317-10327 Positive_regulation denotes stimulated true
T18683 10328-10334 Protein denotes GATA-3
T18684 10335-10342 Entity denotes nuclear true
T18685 10343-10355 Localization denotes localization
T18686 10535-10541 Regulation denotes affect
T18687 10553-10559 Protein denotes GATA-3
T18688 10560-10571 Protein_catabolism denotes degradation
T18689 10598-10604 Protein denotes GATA-3
T18690 10815-10822 Negative_regulation denotes prevent
T18691 10837-10847 Positive_regulation denotes stimulated
T18692 10848-10851 Protein denotes p65
T18693 10852-10859 Entity denotes nuclear
T18694 10860-10873 Localization denotes translocation
T19261 11649-11656 Negative_regulation denotes impairs
T19262 11657-11663 Protein denotes GATA-3
T19263 11664-11675 Binding denotes interaction
T19264 11696-11702 Protein denotes GATA-3
T19265 11703-11710 Entity denotes nuclear
T19266 11711-11723 Localization denotes localization
T19267 11869-11877 Negative_regulation denotes impaired
T19268 11878-11889 Binding denotes interaction
T19269 11898-11904 Protein denotes GATA-3
T19270 12249-12258 Negative_regulation denotes decreased
T19271 12259-12270 Binding denotes association
T19272 12279-12285 Protein denotes GATA-3
T19670 14844-14851 Negative_regulation denotes impairs
T19671 14852-14858 Protein denotes GATA-3
T19672 14859-14866 Entity denotes nuclear
T19673 14867-14879 Localization denotes localization
T19674 14977-14979 Protein denotes GR
T19675 14984-14990 Protein denotes GATA-3
T19676 14991-14998 Entity denotes nuclear
T19677 14999-15011 Localization denotes localisation
T19678 15025-15031 Protein denotes GATA-3
T19679 15377-15386 Regulation denotes dependent
T19680 15387-15395 Negative_regulation denotes decrease
T19681 15399-15406 Entity denotes nuclear
T19682 15407-15417 Gene_expression denotes expression
T19683 15421-15427 Protein denotes GATA-3
T19684 15433-15442 Positive_regulation denotes increased
T19685 15443-15454 Entity denotes cytoplasmic
T19686 15455-15461 Protein denotes GATA-3
T19687 15462-15472 Gene_expression denotes expression
T19688 15554-15563 Regulation denotes dependent
T19689 15564-15572 Negative_regulation denotes decrease
T19690 15576-15583 Entity denotes nuclear
T19691 15584-15594 Gene_expression denotes expression
T19692 15598-15604 Protein denotes GATA-3
T19693 15610-15619 Positive_regulation denotes increased
T19694 15620-15631 Entity denotes cytoplasmic
T19695 15632-15638 Protein denotes GATA-3
T19696 15639-15649 Gene_expression denotes expression
T19697 15693-15698 Protein denotes MEK-1
R7047 T8148 T8150 themeOf GATA-3,Translocation
R7048 T8149 T8150 locationOf Nuclear,Translocation
R7049 T8150 T8147 themeOf Translocation,Effect
R7050 T8151 T8147 themeOf IL-4,Effect
R7051 T8153 T8154 causeOf GATA-3,regulated
R7052 T8154 T8152 themeOf regulated,inhibiting
R7053 T8155 T8156 themeOf IL-4,expression
R7054 T8156 T8154 themeOf expression,regulated
R7055 T8159 T8160 locationOf nuclear,import
R7056 T8160 T8158 themeOf import,stimulated
R7057 T8161 T8160 themeOf GATA-3,import
R7058 T8163 T8165 locationOf nuclear,translocation
R7059 T8164 T8165 themeOf GATA-3,translocation
R7060 T8165 T8162 themeOf translocation,resulted
R7061 T8168 T8167 themeOf loss,sustained
R7062 T8169 T8171 locationOf nuclear,expression
R7063 T8170 T8171 themeOf GATA-3,expression
R7064 T8171 T8168 themeOf expression,loss
R7065 T8172 T8173 locationOf cytoplasmic,retention
R7066 T8173 T8168 themeOf retention,loss
R7067 T8174 T8173 themeOf GATA-3,retention
R7068 T8177 T8179 themeOf IL-4,mRNA expression
R7069 T8178 T8179 themeOf IL-5,mRNA expression
R7070 T8179 T8176 themeOf mRNA expression,stimulated
R7071 T8181 T8182 themeOf GATA-3,binding
R7072 T8182 T8180 themeOf binding,loss
R7073 T8184 T8182 themeOf promoter,binding
R7074 T8184 T8183 partOf promoter,IL-5
R7665 T8892 T8891 themeOf GR,Activated
R7666 T8895 T8894 themeOf GR,activated
R7667 T8895 T8898 themeOf GR,import
R7668 T8896 T8898 themeOf GATA-3,import
R7669 T8897 T8898 locationOf nuclear,import
R7670 T8900 T8899 themeOf GR,interaction
R7671 T8901 T8903 themeOf GR,translocation
R7672 T8902 T8903 locationOf nuclear,translocation
R7673 T8905 T8904 themeOf association,decreased
R7674 T8905 T8907 themeOf association,induced
R7675 T8906 T8907 themeOf GATA-3,induced
R7676 T8906 T8905 themeOf GATA-3,association
R7677 T8907 T8904 themeOf induced,decreased
R7678 T8909 T8911 themeOf GATA-3,import
R7679 T8910 T8911 locationOf nuclear,import
R7680 T8911 T8912 themeOf import,following
R7681 T8911 T8913 themeOf import,attenuated
R7682 T8912 T8913 themeOf following,attenuated
R8156 T9490 T9489 equivalentTo MAPK phosphatase-1,MKP-1
R8157 T9492 T9491 themeOf ATF-2,phosphorylation
R8158 T9495 T9496 themeOf serine,phosphorylation
R8159 T9495 T9494 partOf serine,GATA-3
R8160 T9496 T9497 themeOf phosphorylation,induced
R8161 T9496 T9493 themeOf phosphorylation,reduced
R8162 T9499 T9500 themeOf GATA-3,phosphorylation
R8163 T9500 T9498 themeOf phosphorylation,reduction
R8164 T9502 T9501 themeOf MKP-1,induced
R8165 T9504 T9509 themeOf GATA-3,mRNA expression
R8166 T9504 T9507 themeOf GATA-3,association
R8167 T9504 T9506 themeOf GATA-3,import
R8168 T9505 T9506 locationOf nuclear,import
R8169 T9505 T9509 locationOf nuclear,mRNA expression
R8170 T9506 T9503 themeOf import,effects
R8171 T9507 T9503 themeOf association,effects
R8172 T9508 T9509 themeOf IL-4,mRNA expression
R8173 T9509 T9503 themeOf mRNA expression,effects
R8174 T9511 T9510 themeOf GATA-3,activated
R8175 T9513 T9512 themeOf GR,activated
R8176 T9515 T9514 themeOf GR,activated
R8177 T9515 T9516 causeOf GR,increased
R8178 T9517 T9518 themeOf GR,association
R8179 T9518 T9516 themeOf association,increased
R8180 T9521 T9520 themeOf GATA-3,activated
R8181 T9523 T9524 causeOf GATA-3,block
R8182 T9523 T9522 themeOf GATA-3,activated
R8183 T9525 T9526 themeOf GR,association
R8184 T9526 T9524 themeOf association,block
R8185 T9528 T9531 themeOf GR,associate
R8186 T9528 T9527 themeOf GR,activated
R8187 T9530 T9529 themeOf GATA-3,phospho
R8188 T9530 T9531 themeOf GATA-3,associate
R8189 T9533 T9532 themeOf GR,activated
R8190 T9533 T9534 causeOf GR,attenuates
R8191 T9534 T9538 themeOf attenuates,dependent
R8192 T9535 T9534 themeOf phospho,attenuates
R8193 T9536 T9537 themeOf GATA-3,interaction
R8194 T9536 T9535 themeOf GATA-3,phospho
R8195 T9537 T9534 themeOf interaction,attenuates
R8196 T9540 T9544 causeOf GR,limit
R8197 T9540 T9539 themeOf GR,activated
R8198 T9540 T9541 causeOf GR,compete
R8199 T9542 T9541 themeOf phospho,compete
R8200 T9543 T9542 themeOf GATA-3,phospho
R8201 T9545 T9547 themeOf GATA-3,import
R8202 T9546 T9547 locationOf nuclear,import
R8203 T9547 T9544 themeOf import,limit
R8204 T9549 T9552 themeOf GATA-3,degradation
R8205 T9549 T9551 themeOf GATA-3,export
R8206 T9550 T9551 locationOf nuclear,export
R8207 T9551 T9548 themeOf export,effect
R8208 T9552 T9548 themeOf degradation,effect
R8209 T9554 T9553 themeOf export,inhibits
R8210 T9557 T9559 themeOf GATA-3,localization
R8211 T9558 T9559 locationOf nuclear,localization
R8212 T9559 T9556 themeOf localization,block
R8213 T9561 T9562 themeOf GATA-3,expression
R8214 T9562 T9560 themeOf expression,effect
R8215 T9563 T9564 locationOf nuclear,translocation
R8216 T9566 T9568 themeOf GATA-3,residency
R8217 T9567 T9568 locationOf nuclear,residency
R8218 T9568 T9565 themeOf residency,affect
R8219 T9570 T9571 causeOf GR,enhance
R8220 T9570 T9569 themeOf GR,activated
R8221 T9572 T9574 themeOf GATA-3,export
R8222 T9573 T9574 locationOf nuclear,export
R8223 T9574 T9571 themeOf export,enhance
R8224 T9576 T9578 themeOf GATA-3,import
R8225 T9577 T9578 locationOf nuclear,import
R8226 T9578 T9575 themeOf import,effect
R8227 T9580 T9582 themeOf p65,translocation
R8228 T9581 T9582 locationOf nuclear,translocation
R8229 T9582 T9579 themeOf translocation,effect
R9548 T11161 T11163 themeOf GATA-3,Localization
R9549 T11162 T11163 locationOf Nuclear,Localization
R9550 T11163 T11160 themeOf Localization,Effect
R9551 T11166 T11165 themeOf interaction,decrease
R9552 T11166 T11170 themeOf interaction,attenuated
R9553 T11166 T11169 themeOf interaction,inhibited
R9554 T11167 T11170 themeOf phospho,attenuated
R9555 T11167 T11169 themeOf phospho,inhibited
R9556 T11168 T11166 themeOf GATA-3,interaction
R9557 T11168 T11167 themeOf GATA-3,phospho
R9558 T11172 T11174 themeOf IL-4,expression
R9559 T11173 T11174 themeOf -5,expression
R9560 T11174 T11171 themeOf expression,suppresses
R9561 T11176 T11175 themeOf interaction,attenuated
R9562 T11177 T11176 themeOf GATA-3,interaction
R9563 T11178 T11181 themeOf reduced,dependent
R9564 T11179 T11180 themeOf GATA-3,interaction
R9565 T11180 T11178 themeOf interaction,reduced
R9566 T11183 T11184 themeOf GATA-3,association
R9567 T11184 T11182 themeOf association,decrease
R9568 T11185 T11186 themeOf GATA-3,association
R9569 T11187 T11190 themeOf attenuated,decrease
R9570 T11188 T11187 themeOf interaction,attenuated
R9571 T11188 T11190 themeOf interaction,decrease
R9572 T11189 T11188 themeOf GATA-3,interaction
R9573 T11192 T11191 themeOf localization,affect
R9574 T11193 T11192 themeOf GATA-3,localization
R9575 T11195 T11197 themeOf GR,translocation
R9576 T11196 T11197 locationOf nuclear,translocation
R9577 T11197 T11194 themeOf translocation,increased
R9578 T11200 T11199 themeOf loss,induced
R9579 T11200 T11203 themeOf loss,enhanced
R9580 T11201 T11200 themeOf GATA-3,loss
R9581 T11202 T11203 themeOf GATA-3,enhanced
R9582 T11202 T11200 themeOf GATA-3,loss
R9583 T11205 T11206 locationOf nuclear,localization
R9584 T11206 T11204 themeOf localization,reduces
R9585 T11207 T11206 themeOf GATA-3,localization
R9586 T11208 T11204 causeOf inhibiting,reduces
R9587 T11209 T11208 themeOf phospho,inhibiting
R9588 T11210 T11211 themeOf GATA-3,association
R9589 T11211 T11208 themeOf association,inhibiting
R9590 T11214 T11215 themeOf GATA-3,phosphorylation
R9591 T11215 T11213 themeOf phosphorylation,mediated
R9592 T11217 T11216 themeOf MKP-1,induction
R9593 T11219 T11221 themeOf GATA-3,import
R9594 T11220 T11221 locationOf nuclear,import
R9595 T11221 T11218 themeOf import,suppression
R13720 T15976 T15978 themeOf GATA-3,import
R13721 T15977 T15978 locationOf nuclear,import
R13722 T15978 T15975 themeOf import,inhibits
R13723 T15980 T15979 themeOf GATA-3,translocation
R13724 T15981 T15979 locationOf nucleus,translocation
R13725 T15984 T15985 locationOf nuclear,localization
R13726 T15985 T15983 themeOf localization,impaired
R13727 T15985 T15987 themeOf localization,induced
R13728 T15986 T15985 themeOf GATA-3,localization
R13729 T15987 T15983 themeOf induced,impaired
R13730 T15990 T15992 themeOf IL-4,mRNA expression
R13731 T15991 T15992 themeOf IL-5,mRNA expression
R13732 T15992 T15989 themeOf mRNA expression,inhibits
R13733 T15996 T15995 themeOf stimulated,reduces
R13734 T15997 T15998 themeOf GATA-3,associate
R13735 T15997 T15996 themeOf GATA-3,stimulated
R13736 T15998 T15995 themeOf associate,reduces
R14371 T16766 T16767 themeOf GATA-3,association
R14372 T16767 T16765 themeOf association,reduces
R14373 T16768 T16770 themeOf GATA-3,import
R14374 T16769 T16770 locationOf nuclear,import
R14375 T16770 T16765 themeOf import,reduces
R14376 T16772 T16771 themeOf induction,dependent
R14377 T16773 T16772 themeOf activated,induction
R14378 T16774 T16773 themeOf GR,activated
R14379 T16774 T16775 themeOf GR,interaction
R14380 T16775 T16772 themeOf interaction,induction
R14381 T16776 T16777 themeOf GR,association
R14382 T16779 T16778 themeOf induction,dependent
R14383 T16780 T16779 themeOf activated,induction
R14384 T16781 T16780 themeOf GR,activated
R14385 T16781 T16783 themeOf GR,translocation
R14386 T16782 T16783 locationOf nuclear,translocation
R14387 T16783 T16779 themeOf translocation,induction
R14388 T16785 T16784 themeOf decrease,dependent
R14389 T16786 T16787 themeOf GATA-3,association
R14390 T16787 T16785 themeOf association,decrease
R15068 T17569 T17568 partOf serine,GATA-3
R15069 T17569 T17567 themeOf serine,down-regulation
R15070 T17569 T17570 themeOf serine,phosphorylation
R15071 T17570 T17567 themeOf phosphorylation,down-regulation
R15072 T17573 T17572 themeOf activated transcription factor 2,phosphorylation
R15073 T17574 T17573 equivalentTo ATF-2,activated transcription factor 2
R15074 T17576 T17577 themeOf serine,phosphorylation
R15075 T17576 T17578 partOf serine,GATA-3
R15076 T17577 T17575 themeOf phosphorylation,induced
R15077 T17580 T17579 themeOf MKP-1,induced
R15078 T17582 T17581 themeOf MKP-1,induces
R15626 T18249 T18248 themeOf GATA-3,phospho
R15627 T18250 T18251 causeOf GR,enhances
R15628 T18252 T18253 themeOf GR,binding
R15629 T18253 T18251 themeOf binding,enhances
R15630 T18256 T18255 themeOf GATA-3,activated
R15631 T18258 T18257 themeOf GR,activated
R15632 T18259 T18260 causeOf GATA-3,attenuate
R15633 T18261 T18262 themeOf GR,association
R15634 T18262 T18260 themeOf association,attenuate
R15635 T18264 T18263 themeOf GR,Activated
R15636 T18264 T18266 themeOf GR,interacting
R15637 T18265 T18266 themeOf GATA-3,interacting
R15638 T18269 T18270 themeOf GATA-3,binding
R15639 T18270 T18268 themeOf binding,stimulated
R15640 T18273 T18272 themeOf GR,activated
R15641 T18273 T18274 causeOf GR,attenuation
R15642 T18274 T18277 themeOf attenuation,dependent
R15643 T18275 T18276 themeOf GATA-3,association
R15644 T18276 T18274 themeOf association,attenuation
R15947 T18677 T18679 themeOf GATA-3,export
R15948 T18678 T18679 locationOf nuclear,export
R15949 T18679 T18676 themeOf export,affect
R15950 T18682 T18681 themeOf stimulated,prevent
R15951 T18683 T18685 themeOf GATA-3,localization
R15952 T18684 T18685 locationOf nuclear,localization
R15953 T18685 T18681 themeOf localization,prevent
R15954 T18685 T18682 themeOf localization,stimulated
R15955 T18687 T18688 themeOf GATA-3,degradation
R15956 T18688 T18686 themeOf degradation,affect
R15957 T18691 T18690 themeOf stimulated,prevent
R15958 T18692 T18694 themeOf p65,translocation
R15959 T18693 T18694 locationOf nuclear,translocation
R15960 T18694 T18691 themeOf translocation,stimulated
R15961 T18694 T18690 themeOf translocation,prevent
R16440 T19262 T19263 themeOf GATA-3,interaction
R16441 T19263 T19261 themeOf interaction,impairs
R16442 T19264 T19266 themeOf GATA-3,localization
R16443 T19265 T19266 locationOf nuclear,localization
R16444 T19266 T19261 themeOf localization,impairs
R16445 T19268 T19267 themeOf interaction,impaired
R16446 T19269 T19268 themeOf GATA-3,interaction
R16447 T19271 T19270 themeOf association,decreased
R16448 T19272 T19271 themeOf GATA-3,association
R16798 T19671 T19673 themeOf GATA-3,localization
R16799 T19672 T19673 locationOf nuclear,localization
R16800 T19673 T19670 themeOf localization,impairs
R16801 T19674 T19677 themeOf GR,localisation
R16802 T19675 T19677 themeOf GATA-3,localisation
R16803 T19676 T19677 locationOf nuclear,localisation
R16804 T19681 T19682 locationOf nuclear,expression
R16809 T19687 T19684 themeOf expression,increased
R16805 T19682 T19680 themeOf expression,decrease
R16806 T19683 T19682 themeOf GATA-3,expression
R16807 T19685 T19687 locationOf cytoplasmic,expression
R16808 T19686 T19687 themeOf GATA-3,expression
R16810 T19690 T19691 locationOf nuclear,expression
R16811 T19691 T19689 themeOf expression,decrease
R16812 T19692 T19691 themeOf GATA-3,expression
R16813 T19694 T19696 locationOf cytoplasmic,expression
R16814 T19695 T19696 themeOf GATA-3,expression
R16815 T19696 T19693 themeOf expression,increased