PMC:2674207 / 1804-2107 JSONTXT

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{"project":"sentences","denotations":[{"id":"T145","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T146","span":{"begin":12,"end":148},"obj":"Sentence"},{"id":"T147","span":{"begin":149,"end":303},"obj":"Sentence"},{"id":"T15","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T16","span":{"begin":12,"end":148},"obj":"Sentence"},{"id":"T17","span":{"begin":149,"end":303},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Conclusions\nCorticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression. This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases."}

{"project":"events-check-again","denotations":[{"id":"T917","span":{"begin":42,"end":59},"obj":"Negative_regulation"},{"id":"T918","span":{"begin":63,"end":69},"obj":"Protein"}],"relations":[{"id":"R727","pred":"themeOf","subj":"T918","obj":"T917"}],"text":"Conclusions\nCorticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression. This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases."}

{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T952","span":{"begin":63,"end":69},"obj":"Protein"},{"id":"T953","span":{"begin":124,"end":127},"obj":"Protein"},{"id":"T954","span":{"begin":53,"end":59},"obj":"Negative_regulation"},{"id":"T955","span":{"begin":137,"end":147},"obj":"Gene_expression"},{"id":"T956","span":{"begin":115,"end":123},"obj":"Negative_regulation"}],"relations":[{"id":"R764","pred":"themeOf","subj":"T952","obj":"T954"},{"id":"R765","pred":"themeOf","subj":"T953","obj":"T955"},{"id":"R767","pred":"themeOf","subj":"T955","obj":"T956"}],"text":"Conclusions\nCorticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression. This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases."}

{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T133","span":{"begin":42,"end":59},"obj":"Negative_regulation"},{"id":"T134","span":{"begin":63,"end":69},"obj":"Protein"}],"relations":[{"id":"R98","pred":"themeOf","subj":"T134","obj":"T133"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Conclusions\nCorticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression. This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T453","span":{"begin":63,"end":69},"obj":"P23771"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Conclusions\nCorticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression. This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases."}

{"project":"test2","denotations":[{"id":"T85","span":{"begin":42,"end":59},"obj":"Negative_regulation"},{"id":"T86","span":{"begin":63,"end":69},"obj":"Protein"}],"relations":[{"id":"R70","pred":"themeOf","subj":"T86","obj":"T85"}],"text":"Conclusions\nCorticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression. This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases."}