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2_test

Id Subject Object Predicate Lexical cue
19436703-16903918-86274449 7563-7564 16903918 denotes 1
19436703-10525032-86274450 7690-7691 10525032 denotes 2
19436703-16467870-86274451 7694-7695 16467870 denotes 3
19436703-11336690-86274452 7837-7838 11336690 denotes 4
19436703-11893731-86274453 7841-7842 11893731 denotes 7
19436703-10549629-86274454 8096-8097 10549629 denotes 8
19436703-11390432-86274455 8100-8101 11390432 denotes 9
19436703-14769923-86274456 8223-8225 14769923 denotes 10
19436703-15087456-86274457 8304-8306 15087456 denotes 11
19436703-17277157-86274458 8445-8447 17277157 denotes 12
19436703-11751746-86274459 8700-8702 11751746 denotes 13
19436703-17277157-86274460 8803-8805 17277157 denotes 12
19436703-8114750-86274461 8859-8861 8114750 denotes 14
19436703-17277157-86274462 8971-8973 17277157 denotes 12
19436703-17277157-86274463 9125-9127 17277157 denotes 12
19436703-8114750-86274464 9130-9132 8114750 denotes 14
19436703-15350979-86274465 9215-9217 15350979 denotes 15
19436703-17277157-86274466 9421-9423 17277157 denotes 12
19436703-7510080-86274467 9583-9585 7510080 denotes 16
19436703-16236742-86274468 10145-10147 16236742 denotes 17
19436703-16604091-86274469 10150-10152 16604091 denotes 18
19436703-3123217-86274470 10264-10266 3123217 denotes 19
19436703-17314103-86274471 10299-10301 17314103 denotes 20
19436703-15110988-86274472 10403-10405 15110988 denotes 21
19436703-9891038-86274473 10468-10470 9891038 denotes 22
19436703-15004228-86274474 10640-10642 15004228 denotes 23
19436703-15004228-86274475 10833-10835 15004228 denotes 23
19436703-16610357-86274476 10957-10959 16610357 denotes 24
19436703-16610357-86274477 11123-11125 16610357 denotes 24
19436703-18049904-86274478 11128-11130 18049904 denotes 26
19436703-15591061-86274479 11221-11223 15591061 denotes 27
19436703-15496417-86274480 11226-11228 15496417 denotes 28
19436703-8532532-86274481 11431-11433 8532532 denotes 29
19436703-9780145-86274482 11490-11492 9780145 denotes 30
19436703-12876556-86274483 11495-11497 12876556 denotes 32
19436703-15826950-86274484 11570-11572 15826950 denotes 33
19436703-15860753-86274485 12573-12575 15860753 denotes 34
19436703-17277157-86274486 14137-14139 17277157 denotes 12
19436703-15860753-86274487 14291-14293 15860753 denotes 34
19436703-17277157-86274488 14560-14562 17277157 denotes 12
19436703-11395507-86274489 15267-15269 11395507 denotes 35
19436703-17277157-86274490 16158-16160 17277157 denotes 12
19436703-10958685-86274491 16922-16924 10958685 denotes 36
19436703-15860753-86274492 18609-18611 15860753 denotes 34
19436703-12876556-86274493 23352-23354 12876556 denotes 32
19436703-17277157-86274494 23612-23614 17277157 denotes 12
19436703-11140432-86274495 23954-23956 11140432 denotes 37
19436703-17314103-86274496 25921-25923 17314103 denotes 20
19436703-15496417-86274497 28464-28466 15496417 denotes 28
19436703-15591061-86274498 35990-35992 15591061 denotes 27
19436703-17277157-86274499 40816-40818 17277157 denotes 12
19436703-17277157-86274500 41048-41050 17277157 denotes 12
19436703-9891038-86274501 41150-41152 9891038 denotes 22
19436703-12391149-86274502 42665-42667 12391149 denotes 38
19436703-17099067-86274503 42670-42672 17099067 denotes 39
19436703-11140432-86274504 43736-43738 11140432 denotes 37
19436703-12001789-86274505 44443-44445 12001789 denotes 40
19436703-10887335-86274506 44448-44450 10887335 denotes 42
19436703-16266385-86274507 45231-45233 16266385 denotes 43
T43001 7563-7564 16903918 denotes 1
T70873 7690-7691 10525032 denotes 2
T67559 7694-7695 16467870 denotes 3
T42453 7837-7838 11336690 denotes 4
T56933 7841-7842 11893731 denotes 7
T99552 8096-8097 10549629 denotes 8
T78387 8100-8101 11390432 denotes 9
T31861 8223-8225 14769923 denotes 10
T54483 8304-8306 15087456 denotes 11
T49366 8445-8447 17277157 denotes 12
T50729 8700-8702 11751746 denotes 13
T71477 8803-8805 17277157 denotes 12
T49898 8859-8861 8114750 denotes 14
T29972 8971-8973 17277157 denotes 12
T24249 9125-9127 17277157 denotes 12
T62255 9130-9132 8114750 denotes 14
T15669 9215-9217 15350979 denotes 15
T56526 9421-9423 17277157 denotes 12
T37660 9583-9585 7510080 denotes 16
T62921 10145-10147 16236742 denotes 17
T62400 10150-10152 16604091 denotes 18
T78453 10264-10266 3123217 denotes 19
T63706 10299-10301 17314103 denotes 20
T47506 10403-10405 15110988 denotes 21
T32938 10468-10470 9891038 denotes 22
T41384 10640-10642 15004228 denotes 23
T57828 10833-10835 15004228 denotes 23
T19733 10957-10959 16610357 denotes 24
T68074 11123-11125 16610357 denotes 24
T88055 11128-11130 18049904 denotes 26
T58328 11221-11223 15591061 denotes 27
T37253 11226-11228 15496417 denotes 28
T40125 11431-11433 8532532 denotes 29
T36194 11490-11492 9780145 denotes 30
T8767 11495-11497 12876556 denotes 32
T27072 11570-11572 15826950 denotes 33
T86367 12573-12575 15860753 denotes 34
T38919 14137-14139 17277157 denotes 12
T24071 14291-14293 15860753 denotes 34
T69573 14560-14562 17277157 denotes 12
T8362 15267-15269 11395507 denotes 35
T57036 16158-16160 17277157 denotes 12
T21764 16922-16924 10958685 denotes 36
T87031 18609-18611 15860753 denotes 34
T38523 23352-23354 12876556 denotes 32
T73484 23612-23614 17277157 denotes 12
T58090 23954-23956 11140432 denotes 37
T64889 25921-25923 17314103 denotes 20
T59134 28464-28466 15496417 denotes 28
T7645 35990-35992 15591061 denotes 27
T69957 40816-40818 17277157 denotes 12
T58723 41048-41050 17277157 denotes 12
T89702 41150-41152 9891038 denotes 22
T56173 42665-42667 12391149 denotes 38
T354 42670-42672 17099067 denotes 39
T43358 43736-43738 11140432 denotes 37
T80830 44443-44445 12001789 denotes 40
T19947 44448-44450 10887335 denotes 42
T80216 45231-45233 16266385 denotes 43

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T149 0-11 NN denotes Suppression
T150 12-14 IN denotes of
T151 15-21 NN denotes GATA-3
T152 22-29 JJ denotes Nuclear
T153 30-36 NN denotes Import
T154 37-40 CC denotes and
T155 41-56 NN denotes Phosphorylation
T156 56-57 -COLON- denotes :
T157 58-59 DT denotes A
T158 60-65 NNP denotes Novel
T159 66-75 NNP denotes Mechanism
T160 76-78 IN denotes of
T161 79-93 NN denotes Corticosteroid
T162 94-100 NN denotes Action
T163 101-103 IN denotes in
T164 104-112 JJ denotes Allergic
T165 113-120 NN denotes Disease
T166 455-465 NN denotes Background
T167 466-472 NN denotes GATA-3
T168 473-478 VB denotes plays
T169 479-480 DT denotes a
T170 481-489 JJ denotes critical
T171 490-494 NN denotes role
T172 495-497 IN denotes in
T173 498-508 VB denotes regulating
T174 509-512 DT denotes the
T175 513-523 NN denotes expression
T176 524-526 IN denotes of
T177 527-530 DT denotes the
T178 531-540 NN denotes cytokines
T179 541-552 NN denotes interleukin
T180 553-554 -LRB- denotes (
T181 554-556 NN denotes IL
T182 556-557 -RRB- denotes )
T183 557-559 CD denotes -4
T184 559-560 -COMMA- denotes ,
T185 561-565 NN denotes IL-5
T186 565-566 -COMMA- denotes ,
T187 567-570 CC denotes and
T188 571-576 NN denotes IL-13
T189 577-581 IN denotes from
T190 582-583 NN denotes T
T191 584-592 NN denotes helper-2
T192 593-594 -LRB- denotes (
T193 594-597 NN denotes Th2
T194 597-598 -RRB- denotes )
T195 599-604 NN denotes cells
T196 605-608 CC denotes and
T197 609-618 RB denotes therefore
T198 619-621 VB denotes is
T199 622-623 DT denotes a
T200 624-627 JJ denotes key
T201 628-636 NN denotes mediator
T202 637-639 IN denotes of
T203 640-648 JJ denotes allergic
T204 649-657 NN denotes diseases
T205 659-674 NN denotes Corticosteroids
T206 675-678 VB denotes are
T207 679-685 RB denotes highly
T208 686-695 JJ denotes effective
T209 696-698 IN denotes in
T210 699-710 VB denotes suppressing
T211 711-719 JJ denotes allergic
T212 720-732 NN denotes inflammation
T213 732-733 -COMMA- denotes ,
T214 734-737 CC denotes but
T215 738-743 PRP-DOLLAR- denotes their
T216 744-751 NN denotes effects
T217 752-754 IN denotes on
T218 755-761 NN denotes GATA-3
T219 762-765 VB denotes are
T220 766-773 JJ denotes unknown
T221 775-777 PRP denotes We
T222 778-790 VB denotes investigated
T223 791-794 DT denotes the
T224 795-801 NN denotes effect
T225 802-804 IN denotes of
T226 805-808 DT denotes the
T227 809-823 NN denotes corticosteroid
T228 824-835 NN denotes fluticasone
T229 836-846 NN denotes propionate
T230 847-849 IN denotes on
T231 850-856 NN denotes GATA-3
T232 857-867 NN denotes regulation
T233 868-870 IN denotes in
T234 871-876 JJ denotes human
T235 877-890 NN denotes T-lymphocytes
T236 891-893 FW denotes in
T237 894-899 FW denotes vitro
T238 900-903 CC denotes and
T239 904-906 FW denotes in
T240 907-911 FW denotes vivo
T241 914-921 NN denotes Methods
T242 922-925 CC denotes and
T243 926-934 NN denotes Findings
T244 935-937 IN denotes In
T245 938-939 DT denotes a
T246 940-941 NN denotes T
T247 942-952 NN denotes lymphocyte
T248 953-957 NN denotes cell
T249 958-962 NN denotes line
T250 963-964 -LRB- denotes (
T251 964-970 NN denotes HuT-78
T252 970-971 -RRB- denotes )
T253 972-975 CC denotes and
T254 976-986 JJ denotes peripheral
T255 987-992 NN denotes blood
T256 993-1004 JJ denotes mononuclear
T257 1005-1010 NN denotes cells
T258 1011-1021 VB denotes stimulated
T259 1022-1024 IN denotes by
T260 1025-1033 JJ denotes anti-CD3
T261 1034-1037 CC denotes and
T262 1038-1047 JJ denotes anti-CD28
T263 1048-1050 FW denotes in
T264 1051-1056 FW denotes vitro
T265 1057-1059 PRP denotes we
T266 1060-1072 VB denotes demonstrated
T267 1073-1077 IN denotes that
T268 1078-1089 NN denotes fluticasone
T269 1090-1098 VB denotes inhibits
T270 1099-1106 JJ denotes nuclear
T271 1107-1120 NN denotes translocation
T272 1121-1123 IN denotes of
T273 1124-1130 NN denotes GATA-3
T274 1131-1134 CC denotes and
T275 1135-1145 NN denotes expression
T276 1146-1148 IN denotes of
T277 1149-1152 NN denotes Th2
T278 1153-1162 NN denotes cytokines
T279 1163-1166 IN denotes via
T280 1167-1168 DT denotes a
T281 1169-1178 NN denotes mechanism
T282 1179-1190 JJ denotes independent
T283 1191-1193 IN denotes of
T284 1194-1201 JJ denotes nuclear
T285 1202-1211 NN denotes factor-κB
T286 1212-1215 CC denotes and
T287 1216-1218 VB denotes is
T288 1219-1222 JJ denotes due
T289 1222-1223 -COMMA- denotes ,
T290 1224-1226 IN denotes in
T291 1227-1231 NN denotes part
T292 1231-1232 -COMMA- denotes ,
T293 1233-1235 TO denotes to
T294 1236-1247 NN denotes competition
T295 1248-1255 IN denotes between
T296 1256-1262 NN denotes GATA-3
T297 1263-1266 CC denotes and
T298 1267-1270 DT denotes the
T299 1271-1287 JJ denotes ligand-activated
T300 1288-1302 NN denotes glucocorticoid
T301 1303-1311 NN denotes receptor
T302 1312-1315 IN denotes for
T303 1316-1323 JJ denotes nuclear
T304 1324-1333 NN denotes transport
T305 1334-1341 IN denotes through
T306 1342-1345 DT denotes the
T307 1346-1353 JJ denotes nuclear
T308 1354-1362 NN denotes importer
T309 1363-1373 NN denotes importin-α
T310 1375-1377 IN denotes In
T311 1378-1386 NN denotes addition
T312 1386-1387 -COMMA- denotes ,
T313 1388-1399 NN denotes fluticasone
T314 1400-1407 VB denotes induces
T315 1408-1411 DT denotes the
T316 1412-1422 NN denotes expression
T317 1423-1425 IN denotes of
T318 1426-1443 JJ denotes mitogen-activated
T319 1444-1451 NN denotes protein
T320 1452-1458 NN denotes kinase
T321 1459-1460 -LRB- denotes (
T322 1460-1464 NN denotes MAPK
T323 1464-1465 -RRB- denotes )
T324 1466-1479 NN denotes phosphatase-1
T325 1480-1481 -LRB- denotes (
T326 1481-1486 NN denotes MKP-1
T327 1486-1487 -RRB- denotes )
T328 1487-1488 -COMMA- denotes ,
T329 1489-1492 DT denotes the
T330 1493-1503 JJ denotes endogenous
T331 1504-1513 NN denotes inhibitor
T332 1514-1516 IN denotes of
T333 1517-1520 NN denotes p38
T334 1521-1525 NN denotes MAPK
T335 1525-1526 -COMMA- denotes ,
T336 1527-1532 WDT denotes which
T337 1533-1535 VB denotes is
T338 1536-1545 JJ denotes necessary
T339 1546-1549 IN denotes for
T340 1550-1556 NN denotes GATA-3
T341 1557-1564 JJ denotes nuclear
T342 1565-1578 NN denotes translocation
T343 1580-1585 DT denotes These
T344 1586-1596 JJ denotes inhibitory
T345 1597-1604 NN denotes effects
T346 1605-1607 IN denotes of
T347 1608-1619 NN denotes fluticasone
T348 1620-1623 VB denotes are
T349 1624-1629 JJ denotes rapid
T350 1629-1630 -COMMA- denotes ,
T351 1631-1637 JJ denotes potent
T352 1637-1638 -COMMA- denotes ,
T353 1639-1642 CC denotes and
T354 1643-1652 VB denotes prolonged
T355 1654-1656 PRP denotes We
T356 1657-1661 RB denotes also
T357 1662-1674 VB denotes demonstrated
T358 1675-1679 IN denotes that
T359 1680-1687 VB denotes inhaled
T360 1688-1699 NN denotes fluticasone
T361 1700-1708 VB denotes inhibits
T362 1709-1715 NN denotes GATA-3
T363 1716-1723 JJ denotes nuclear
T364 1724-1737 NN denotes translocation
T365 1738-1740 IN denotes in
T366 1741-1751 JJ denotes peripheral
T367 1752-1757 NN denotes blood
T368 1758-1769 NN denotes lymphocytes
T369 1770-1772 IN denotes of
T370 1773-1781 NN denotes patients
T371 1782-1786 IN denotes with
T372 1787-1793 NN denotes asthma
T373 1794-1796 FW denotes in
T374 1797-1801 FW denotes vivo
T375 1804-1815 NN denotes Conclusions
T376 1816-1831 NN denotes Corticosteroids
T377 1832-1836 VB denotes have
T378 1837-1838 DT denotes a
T379 1839-1845 JJ denotes potent
T380 1846-1856 JJ denotes inhibitory
T381 1857-1863 NN denotes effect
T382 1864-1866 IN denotes on
T383 1867-1873 NN denotes GATA-3
T384 1874-1877 IN denotes via
T385 1878-1881 CD denotes two
T386 1882-1893 VB denotes interacting
T387 1894-1904 NN denotes mechanisms
T388 1905-1909 WDT denotes that
T389 1910-1918 RB denotes potently
T390 1919-1927 VB denotes suppress
T391 1928-1931 NN denotes Th2
T392 1932-1940 NN denotes cytokine
T393 1941-1951 NN denotes expression
T394 1953-1957 DT denotes This
T395 1958-1963 JJ denotes novel
T396 1964-1973 NN denotes mechanism
T397 1974-1976 IN denotes of
T398 1977-1983 NN denotes action
T399 1984-1986 IN denotes of
T400 1987-2002 NN denotes corticosteroids
T401 2003-2006 MD denotes may
T402 2007-2014 VB denotes account
T403 2015-2018 IN denotes for
T404 2019-2022 DT denotes the
T405 2023-2031 JJ denotes striking
T406 2032-2040 JJ denotes clinical
T407 2041-2049 NN denotes efficacy
T408 2050-2052 IN denotes of
T409 2053-2068 NN denotes corticosteroids
T410 2069-2071 IN denotes in
T411 2072-2075 DT denotes the
T412 2076-2085 NN denotes treatment
T413 2086-2088 IN denotes of
T414 2089-2097 JJ denotes allergic
T415 2098-2106 NN denotes diseases
T416 2109-2115 VB denotes Please
T417 2116-2119 VB denotes see
T418 2120-2125 RB denotes later
T419 2126-2128 IN denotes in
T420 2129-2132 DT denotes the
T421 2133-2140 NN denotes article
T422 2141-2144 IN denotes for
T423 2145-2152 NN denotes Editors
T424 2152-2153 POS denotes '
T425 2154-2161 JJ denotes Summary
T1321 7246-7258 NN denotes Inflammation
T1322 7259-7261 IN denotes in
T1323 7262-7270 JJ denotes allergic
T1324 7271-7279 NN denotes diseases
T1325 7280-7284 JJ denotes such
T1326 7285-7287 IN denotes as
T1327 7288-7294 NN denotes asthma
T1328 7294-7295 -COMMA- denotes ,
T1329 7296-7304 NN denotes rhinitis
T1330 7304-7305 -COMMA- denotes ,
T1331 7306-7309 CC denotes and
T1332 7310-7316 JJ denotes atopic
T1333 7317-7327 NN denotes dermatitis
T1334 7328-7330 VB denotes is
T1335 7331-7339 VB denotes mediated
T1336 7340-7343 IN denotes via
T1337 7344-7354 NN denotes expression
T1338 7355-7357 IN denotes of
T1339 7358-7361 DT denotes the
T1340 7362-7371 NN denotes cytokines
T1341 7372-7383 NN denotes interleukin
T1342 7384-7385 -LRB- denotes (
T1343 7385-7387 NN denotes IL
T1344 7387-7388 -RRB- denotes )
T1345 7388-7390 CD denotes -4
T1346 7390-7391 -COMMA- denotes ,
T1347 7392-7396 NN denotes IL-5
T1348 7396-7397 -COMMA- denotes ,
T1349 7398-7401 CC denotes and
T1350 7402-7407 NN denotes IL-13
T1351 7408-7412 IN denotes from
T1352 7413-7414 NN denotes T
T1353 7415-7423 NN denotes helper-2
T1354 7424-7425 -LRB- denotes (
T1355 7425-7428 NN denotes Th2
T1356 7428-7429 -RRB- denotes )
T1357 7430-7435 NN denotes cells
T1358 7437-7441 NN denotes IL-4
T1359 7442-7445 CC denotes and
T1360 7446-7451 NN denotes IL-13
T1361 7452-7460 VB denotes regulate
T1362 7461-7464 DT denotes the
T1363 7465-7475 NN denotes expression
T1364 7476-7478 IN denotes of
T1365 7479-7482 NN denotes IgE
T1366 7483-7487 IN denotes from
T1367 7488-7489 NN denotes B
T1368 7490-7501 NN denotes lymphocytes
T1369 7501-7502 -COMMA- denotes ,
T1370 7503-7510 IN denotes whereas
T1371 7511-7515 NN denotes IL-5
T1372 7516-7521 VB denotes plays
T1373 7522-7523 DT denotes a
T1374 7524-7527 JJ denotes key
T1375 7528-7532 NN denotes role
T1376 7533-7535 IN denotes in
T1377 7536-7548 JJ denotes eosinophilic
T1378 7549-7561 NN denotes inflammation
T1379 7562-7563 -LRB- denotes [
T1380 7563-7564 CD denotes 1
T1381 7564-7565 -RRB- denotes ]
T1382 7567-7570 NN denotes Th2
T1383 7571-7580 NN denotes cytokines
T1384 7581-7584 VB denotes are
T1385 7585-7594 VB denotes regulated
T1386 7595-7597 IN denotes by
T1387 7598-7601 DT denotes the
T1388 7602-7606 NN denotes zinc
T1389 7607-7613 NN denotes finger
T1390 7614-7627 NN denotes transcription
T1391 7628-7634 NN denotes factor
T1392 7635-7641 NN denotes GATA-3
T1393 7641-7642 -COMMA- denotes ,
T1394 7643-7648 WDT denotes which
T1395 7649-7651 VB denotes is
T1396 7652-7665 RB denotes predominantly
T1397 7666-7675 VB denotes expressed
T1398 7676-7678 IN denotes in
T1399 7679-7682 NN denotes Th2
T1400 7683-7688 NN denotes cells
T1401 7689-7690 -LRB- denotes [
T1402 7690-7691 CD denotes 2
T1403 7691-7692 -RRB- denotes ]
T1404 7692-7693 -COMMA- denotes ,
T1405 7693-7694 -LRB- denotes [
T1406 7694-7695 CD denotes 3
T1407 7695-7696 -RRB- denotes ]
T1408 7698-7704 NN denotes GATA-3
T1409 7705-7715 VB denotes determines
T1410 7716-7719 NN denotes Th2
T1411 7720-7724 NN denotes cell
T1412 7725-7740 NN denotes differentiation
T1413 7741-7744 CC denotes and
T1414 7745-7756 RB denotes selectively
T1415 7757-7766 VB denotes activates
T1416 7767-7770 DT denotes the
T1417 7771-7780 NN denotes promoters
T1418 7781-7783 IN denotes of
T1419 7784-7788 NN denotes IL-4
T1420 7788-7789 -COMMA- denotes ,
T1421 7790-7794 NN denotes IL-5
T1422 7794-7795 -COMMA- denotes ,
T1423 7796-7799 CC denotes and
T1424 7800-7805 NN denotes IL-13
T1425 7806-7813 IN denotes through
T1426 7814-7823 NN denotes chromatin
T1427 7824-7835 VB denotes remodelling
T1428 7836-7837 -LRB- denotes [
T1429 7837-7838 CD denotes 4
T1430 7838-7839 -RRB- denotes ]
T1431 7839-7840 NN denotes –
T1432 7840-7841 -LRB- denotes [
T1433 7841-7842 CD denotes 7
T1434 7842-7843 -RRB- denotes ]
T1435 7845-7848 DT denotes The
T1436 7849-7852 JJ denotes key
T1437 7853-7857 NN denotes role
T1438 7858-7860 IN denotes of
T1439 7861-7867 NN denotes GATA-3
T1440 7868-7870 IN denotes in
T1441 7871-7879 JJ denotes allergic
T1442 7880-7886 NN denotes airway
T1443 7887-7899 NN denotes inflammation
T1444 7900-7903 VB denotes has
T1445 7904-7908 VB denotes been
T1446 7909-7921 VB denotes demonstrated
T1447 7922-7924 IN denotes in
T1448 7925-7929 NN denotes mice
T1449 7930-7932 IN denotes by
T1450 7933-7936 DT denotes the
T1451 7937-7944 VB denotes reduced
T1452 7945-7952 NN denotes release
T1453 7953-7955 IN denotes of
T1454 7956-7959 NN denotes Th2
T1455 7960-7969 NN denotes cytokines
T1456 7970-7972 IN denotes in
T1457 7973-7980 NN denotes animals
T1458 7981-7988 VB denotes treated
T1459 7989-7993 IN denotes with
T1460 7994-8011 JJ denotes dominant-negative
T1461 8012-8019 NN denotes mutants
T1462 8020-8022 IN denotes of
T1463 8023-8029 NN denotes GATA-3
T1464 8030-8033 CC denotes and
T1465 8034-8036 IN denotes by
T1466 8037-8042 JJ denotes local
T1467 8043-8054 NN denotes application
T1468 8055-8057 IN denotes of
T1469 8058-8067 JJ denotes antisense
T1470 8068-8084 NN denotes oligonucleotides
T1471 8085-8087 TO denotes to
T1472 8088-8094 NN denotes GATA-3
T1473 8095-8096 -LRB- denotes [
T1474 8096-8097 CD denotes 8
T1475 8097-8098 -RRB- denotes ]
T1476 8098-8099 -COMMA- denotes ,
T1477 8099-8100 -LRB- denotes [
T1478 8100-8101 CD denotes 9
T1479 8101-8102 -RRB- denotes ]
T1480 8104-8115 RB denotes Furthermore
T1481 8115-8116 -COMMA- denotes ,
T1482 8117-8128 JJ denotes conditional
T1483 8129-8138 NN denotes knock-out
T1484 8139-8141 IN denotes of
T1485 8142-8145 DT denotes the
T1486 8146-8151 NN denotes Gata3
T1487 8152-8156 NN denotes gene
T1488 8157-8159 IN denotes in
T1489 8160-8164 NN denotes mice
T1490 8165-8172 VB denotes reduces
T1491 8173-8183 NN denotes expression
T1492 8184-8186 IN denotes of
T1493 8187-8190 NN denotes Th2
T1494 8191-8200 NN denotes cytokines
T1495 8201-8203 FW denotes in
T1496 8204-8209 FW denotes vitro
T1497 8210-8213 CC denotes and
T1498 8214-8216 FW denotes in
T1499 8217-8221 FW denotes vivo
T1500 8222-8223 -LRB- denotes [
T1501 8223-8225 CD denotes 10
T1502 8225-8226 -RRB- denotes ]
T1503 8226-8227 -COMMA- denotes ,
T1504 8228-8231 CC denotes and
T1505 8232-8239 JJ denotes similar
T1506 8240-8247 NN denotes results
T1507 8248-8252 VB denotes have
T1508 8253-8257 VB denotes been
T1509 8258-8266 VB denotes reported
T1510 8267-8269 IN denotes in
T1511 8270-8278 VB denotes isolated
T1512 8279-8285 JJ denotes murine
T1513 8286-8290 JJ denotes CD4+
T1514 8291-8302 NN denotes lymphocytes
T1515 8303-8304 -LRB- denotes [
T1516 8304-8306 CD denotes 11
T1517 8306-8307 -RRB- denotes ]
T1518 8309-8316 RB denotes Finally
T1519 8316-8317 -COMMA- denotes ,
T1520 8318-8327 NN denotes knockdown
T1521 8328-8330 IN denotes of
T1522 8331-8337 NN denotes GATA-3
T1523 8338-8348 NN denotes expression
T1524 8349-8354 VB denotes using
T1525 8355-8360 NN denotes siRNA
T1526 8361-8363 IN denotes in
T1527 8364-8369 JJ denotes human
T1528 8370-8371 NN denotes T
T1529 8372-8377 NN denotes cells
T1530 8378-8385 VB denotes results
T1531 8386-8388 IN denotes in
T1532 8389-8393 NN denotes loss
T1533 8394-8396 IN denotes of
T1534 8397-8419 JJ denotes anti-CD3/CD28-mediated
T1535 8420-8423 NN denotes Th2
T1536 8424-8432 NN denotes cytokine
T1537 8433-8443 NN denotes expression
T1538 8444-8445 -LRB- denotes [
T1539 8445-8447 CD denotes 12
T1540 8447-8448 -RRB- denotes ]
T1541 8450-8452 IN denotes In
T1542 8453-8458 NN denotes order
T1543 8459-8462 IN denotes for
T1544 8463-8469 NN denotes GATA-3
T1545 8470-8472 TO denotes to
T1546 8473-8481 VB denotes regulate
T1547 8482-8486 NN denotes gene
T1548 8487-8497 NN denotes expression
T1549 8497-8498 -COMMA- denotes ,
T1550 8499-8501 PRP denotes it
T1551 8502-8506 MD denotes must
T1552 8507-8518 VB denotes translocate
T1553 8519-8523 IN denotes from
T1554 8524-8527 DT denotes the
T1555 8528-8537 NN denotes cytoplasm
T1556 8538-8542 IN denotes into
T1557 8543-8546 DT denotes the
T1558 8547-8554 NN denotes nucleus
T1559 8555-8557 TO denotes to
T1560 8558-8564 VB denotes access
T1561 8565-8568 PRP-DOLLAR- denotes its
T1562 8569-8575 NN denotes target
T1563 8576-8581 NN denotes genes
T1564 8583-8591 VB denotes Enhanced
T1565 8592-8599 JJ denotes nuclear
T1566 8600-8610 NN denotes expression
T1567 8611-8613 IN denotes of
T1568 8614-8620 NN denotes GATA-3
T1569 8621-8630 VB denotes following
T1570 8631-8632 NN denotes T
T1571 8633-8637 NN denotes cell
T1572 8638-8646 NN denotes receptor
T1573 8647-8657 NN denotes activation
T1574 8658-8661 VB denotes was
T1575 8662-8667 RB denotes first
T1576 8668-8680 VB denotes demonstrated
T1577 8681-8683 IN denotes in
T1578 8684-8690 JJ denotes murine
T1579 8691-8692 NN denotes T
T1580 8693-8698 NN denotes cells
T1581 8699-8700 -LRB- denotes [
T1582 8700-8702 CD denotes 13
T1583 8702-8703 -RRB- denotes ]
T1584 8704-8707 CC denotes and
T1585 8708-8711 VB denotes was
T1586 8712-8720 RB denotes recently
T1587 8721-8730 VB denotes confirmed
T1588 8731-8733 IN denotes in
T1589 8734-8739 JJ denotes human
T1590 8740-8741 NN denotes T
T1591 8742-8747 NN denotes cells
T1592 8748-8757 VB denotes following
T1593 8758-8759 NN denotes T
T1594 8760-8764 NN denotes cell
T1595 8765-8773 NN denotes receptor
T1596 8774-8777 CC denotes and
T1597 8778-8789 NN denotes co-receptor
T1598 8790-8801 NN denotes stimulation
T1599 8802-8803 -LRB- denotes [
T1600 8803-8805 CD denotes 12
T1601 8805-8806 -RRB- denotes ]
T1602 8808-8814 NN denotes GATA-3
T1603 8815-8823 VB denotes contains
T1604 8824-8825 DT denotes a
T1605 8826-8835 JJ denotes classical
T1606 8836-8843 JJ denotes nuclear
T1607 8844-8850 NN denotes import
T1608 8851-8857 NN denotes signal
T1609 8858-8859 -LRB- denotes [
T1610 8859-8861 CD denotes 14
T1611 8861-8862 -RRB- denotes ]
T1612 8863-8866 CC denotes and
T1613 8867-8869 VB denotes is
T1614 8870-8881 VB denotes transported
T1615 8882-8886 IN denotes into
T1616 8887-8890 DT denotes the
T1617 8891-8898 NN denotes nucleus
T1618 8899-8901 IN denotes by
T1619 8902-8905 DT denotes the
T1620 8906-8913 JJ denotes nuclear
T1621 8914-8920 NN denotes import
T1622 8921-8928 NN denotes protein
T1623 8929-8939 NN denotes importin-α
T1624 8940-8941 -LRB- denotes (
T1625 8941-8945 RB denotes also
T1626 8946-8951 VB denotes known
T1627 8952-8954 IN denotes as
T1628 8955-8968 NN denotes karyopherin-α
T1629 8968-8969 -RRB- denotes )
T1630 8970-8971 -LRB- denotes [
T1631 8971-8973 CD denotes 12
T1632 8973-8974 -RRB- denotes ]
T1633 8976-8984 NN denotes Deletion
T1634 8985-8987 IN denotes of
T1635 8988-8989 DT denotes a
T1636 8990-8996 NN denotes region
T1637 8997-9009 VB denotes encompassing
T1638 9010-9013 DT denotes the
T1639 9014-9020 NN denotes GATA-3
T1640 9021-9028 JJ denotes nuclear
T1641 9029-9041 NN denotes localisation
T1642 9042-9050 NN denotes sequence
T1643 9051-9052 -LRB- denotes (
T1644 9052-9055 NN denotes NLS
T1645 9055-9056 -RRB- denotes )
T1646 9057-9063 NN denotes region
T1647 9064-9066 IN denotes in
T1648 9067-9073 JJ denotes murine
T1649 9074-9077 CC denotes and
T1650 9078-9083 JJ denotes human
T1651 9084-9089 NN denotes cells
T1652 9090-9098 VB denotes prevents
T1653 9099-9102 PRP-DOLLAR- denotes its
T1654 9103-9110 JJ denotes nuclear
T1655 9111-9123 NN denotes localisation
T1656 9124-9125 -LRB- denotes [
T1657 9125-9127 CD denotes 12
T1658 9127-9128 -RRB- denotes ]
T1659 9128-9129 -COMMA- denotes ,
T1660 9129-9130 -LRB- denotes [
T1661 9130-9132 CD denotes 14
T1662 9132-9133 -RRB- denotes ]
T1663 9135-9138 DT denotes The
T1664 9139-9147 NN denotes affinity
T1665 9148-9150 IN denotes of
T1666 9151-9154 DT denotes the
T1667 9155-9169 JJ denotes importin-α–NLS
T1668 9170-9181 NN denotes interaction
T1669 9182-9184 VB denotes is
T1670 9185-9194 VB denotes regulated
T1671 9195-9197 IN denotes by
T1672 9198-9213 NN denotes phosphorylation
T1673 9214-9215 -LRB- denotes [
T1674 9215-9217 CD denotes 15
T1675 9217-9218 -RRB- denotes ]
T1676 9218-9219 -COMMA- denotes ,
T1677 9220-9223 CC denotes and
T1678 9224-9226 PRP denotes we
T1679 9227-9231 VB denotes have
T1680 9232-9237 VB denotes shown
T1681 9238-9242 IN denotes that
T1682 9243-9246 NN denotes p38
T1683 9247-9264 JJ denotes mitogen-activated
T1684 9265-9272 NN denotes protein
T1685 9273-9279 NN denotes kinase
T1686 9280-9281 -LRB- denotes (
T1687 9281-9285 NN denotes MAPK
T1688 9285-9286 -RRB- denotes )
T1689 9287-9292 VB denotes plays
T1690 9293-9294 DT denotes a
T1691 9295-9303 JJ denotes critical
T1692 9304-9308 NN denotes role
T1693 9309-9311 IN denotes in
T1694 9312-9327 VB denotes phosphorylating
T1695 9328-9334 NN denotes GATA-3
T1696 9335-9337 TO denotes to
T1697 9338-9345 VB denotes enhance
T1698 9346-9349 PRP-DOLLAR- denotes its
T1699 9350-9361 NN denotes interaction
T1700 9362-9366 IN denotes with
T1701 9367-9377 JJ denotes importin-α
T1702 9378-9381 CC denotes and
T1703 9382-9392 JJ denotes subsequent
T1704 9393-9402 NN denotes transport
T1705 9403-9407 IN denotes into
T1706 9408-9411 DT denotes the
T1707 9412-9419 NN denotes nucleus
T1708 9420-9421 -LRB- denotes [
T1709 9421-9423 CD denotes 12
T1710 9423-9424 -RRB- denotes ]
T1711 9426-9441 NN denotes Corticosteroids
T1712 9442-9445 VB denotes are
T1713 9446-9452 RB denotes highly
T1714 9453-9462 JJ denotes effective
T1715 9463-9465 IN denotes in
T1716 9466-9469 DT denotes the
T1717 9470-9479 NN denotes treatment
T1718 9480-9482 IN denotes of
T1719 9483-9491 JJ denotes allergic
T1720 9492-9504 NN denotes inflammation
T1721 9504-9505 -COMMA- denotes ,
T1722 9506-9510 IN denotes with
T1723 9511-9517 JJ denotes marked
T1724 9518-9529 NN denotes suppression
T1725 9530-9532 IN denotes of
T1726 9533-9536 NN denotes Th2
T1727 9537-9546 NN denotes cytokines
T1728 9547-9549 IN denotes in
T1729 9550-9557 NN denotes airways
T1730 9558-9560 IN denotes of
T1731 9561-9569 NN denotes patients
T1732 9570-9574 IN denotes with
T1733 9575-9581 NN denotes asthma
T1734 9582-9583 -LRB- denotes [
T1735 9583-9585 CD denotes 16
T1736 9585-9586 -RRB- denotes ]
T1737 9588-9603 NN denotes Corticosteroids
T1738 9604-9611 VB denotes mediate
T1739 9612-9617 PRP-DOLLAR- denotes their
T1740 9618-9635 JJ denotes anti-inflammatory
T1741 9636-9643 NN denotes effects
T1742 9644-9651 IN denotes through
T1743 9652-9659 NN denotes binding
T1744 9660-9662 TO denotes to
T1745 9663-9677 NN denotes glucocorticoid
T1746 9678-9687 NN denotes receptors
T1747 9688-9689 -LRB- denotes (
T1748 9689-9692 NN denotes GRs
T1749 9692-9693 -RRB- denotes )
T1750 9693-9694 -COMMA- denotes ,
T1751 9695-9700 WDT denotes which
T1752 9701-9705 RB denotes then
T1753 9706-9717 VB denotes translocate
T1754 9718-9720 TO denotes to
T1755 9721-9724 DT denotes the
T1756 9725-9732 NN denotes nucleus
T1757 9733-9738 WRB denotes where
T1758 9739-9743 PRP denotes they
T1759 9744-9752 VB denotes interact
T1760 9753-9757 IN denotes with
T1761 9758-9772 NN denotes glucocorticoid
T1762 9773-9781 NN denotes response
T1763 9782-9790 NN denotes elements
T1764 9791-9792 -LRB- denotes (
T1765 9792-9796 NN denotes GREs
T1766 9796-9797 -RRB- denotes )
T1767 9798-9800 IN denotes in
T1768 9801-9804 DT denotes the
T1769 9805-9813 NN denotes promoter
T1770 9814-9821 NN denotes regions
T1771 9822-9824 IN denotes of
T1772 9825-9842 JJ denotes steroid-sensitive
T1773 9843-9848 NN denotes genes
T1774 9850-9863 RB denotes Alternatively
T1775 9863-9864 -COMMA- denotes ,
T1776 9865-9874 VB denotes activated
T1777 9875-9877 NN denotes GR
T1778 9878-9887 VB denotes interacts
T1779 9888-9892 IN denotes with
T1780 9893-9904 NN denotes coactivator
T1781 9905-9914 NN denotes molecules
T1782 9915-9917 TO denotes to
T1783 9918-9926 VB denotes suppress
T1784 9927-9930 DT denotes the
T1785 9931-9941 NN denotes expression
T1786 9942-9944 IN denotes of
T1787 9945-9957 JJ denotes inflammatory
T1788 9958-9963 NN denotes genes
T1789 9964-9966 IN denotes by
T1790 9967-9977 VB denotes inhibiting
T1791 9978-9981 DT denotes the
T1792 9982-9988 NN denotes action
T1793 9989-9991 IN denotes of
T1794 9992-10007 JJ denotes proinflammatory
T1795 10008-10021 NN denotes transcription
T1796 10022-10029 NN denotes factors
T1797 10030-10034 JJ denotes such
T1798 10035-10037 IN denotes as
T1799 10038-10045 JJ denotes nuclear
T1800 10046-10055 NN denotes factor-κB
T1801 10056-10057 -LRB- denotes (
T1802 10057-10062 NN denotes NF-κB
T1803 10062-10063 -RRB- denotes )
T1804 10064-10071 IN denotes through
T1805 10072-10075 DT denotes the
T1806 10076-10087 NN denotes recruitment
T1807 10088-10090 IN denotes of
T1808 10091-10103 NN denotes co-repressor
T1809 10104-10113 NN denotes molecules
T1810 10114-10118 JJ denotes such
T1811 10119-10121 IN denotes as
T1812 10122-10129 NN denotes histone
T1813 10130-10143 NN denotes deacetylase-2
T1814 10144-10145 -LRB- denotes [
T1815 10145-10147 CD denotes 17
T1816 10147-10148 -RRB- denotes ]
T1817 10148-10149 -COMMA- denotes ,
T1818 10149-10150 -LRB- denotes [
T1819 10150-10152 CD denotes 18
T1820 10152-10153 -RRB- denotes ]
T1821 10155-10162 JJ denotes Nuclear
T1822 10163-10175 NN denotes localisation
T1823 10176-10179 CC denotes and
T1824 10180-10189 NN denotes retention
T1825 10190-10192 IN denotes of
T1826 10193-10195 NN denotes GR
T1827 10196-10198 VB denotes is
T1828 10199-10207 VB denotes mediated
T1829 10208-10215 IN denotes through
T1830 10216-10219 DT denotes the
T1831 10220-10227 JJ denotes nuclear
T1832 10228-10240 NN denotes localisation
T1833 10241-10250 NN denotes sequences
T1834 10251-10254 NN denotes NL1
T1835 10255-10258 CC denotes and
T1836 10259-10262 NN denotes NL2
T1837 10263-10264 -LRB- denotes [
T1838 10264-10266 CD denotes 19
T1839 10266-10267 -RRB- denotes ]
T1840 10267-10268 -COMMA- denotes ,
T1841 10269-10271 IN denotes by
T1842 10272-10279 JJ denotes nuclear
T1843 10280-10289 NN denotes retention
T1844 10290-10297 NN denotes signals
T1845 10298-10299 -LRB- denotes [
T1846 10299-10301 CD denotes 20
T1847 10301-10302 -RRB- denotes ]
T1848 10302-10303 -COMMA- denotes ,
T1849 10304-10307 CC denotes and
T1850 10308-10310 IN denotes by
T1851 10311-10318 NN denotes control
T1852 10319-10321 IN denotes of
T1853 10322-10329 JJ denotes nuclear
T1854 10330-10336 NN denotes export
T1855 10337-10340 IN denotes via
T1856 10341-10342 DT denotes a
T1857 10343-10354 JJ denotes chromosomal
T1858 10355-10361 NN denotes region
T1859 10362-10373 NN denotes maintenance
T1860 10374-10375 CD denotes 1
T1861 10376-10377 -LRB- denotes (
T1862 10377-10382 NN denotes CRM-1
T1863 10382-10383 -RRB- denotes )
T1864 10384-10393 JJ denotes dependent
T1865 10394-10401 NN denotes pathway
T1866 10402-10403 -LRB- denotes [
T1867 10403-10405 CD denotes 21
T1868 10405-10406 -RRB- denotes ]
T1869 10408-10411 NN denotes NL1
T1870 10411-10412 -COMMA- denotes ,
T1871 10413-10418 WDT denotes which
T1872 10419-10421 VB denotes is
T1873 10422-10429 JJ denotes similar
T1874 10430-10432 TO denotes to
T1875 10433-10436 DT denotes the
T1876 10437-10441 NN denotes SV40
T1877 10442-10445 NN denotes NLS
T1878 10445-10446 -COMMA- denotes ,
T1879 10447-10452 VB denotes binds
T1880 10453-10455 TO denotes to
T1881 10456-10466 JJ denotes importin-α
T1882 10467-10468 -LRB- denotes [
T1883 10468-10470 CD denotes 22
T1884 10470-10471 -RRB- denotes ]
T1885 10473-10476 NN denotes NL1
T1886 10477-10479 VB denotes is
T1887 10480-10489 VB denotes activated
T1888 10490-10494 CC denotes both
T1889 10495-10497 IN denotes by
T1890 10498-10512 NN denotes glucocorticoid
T1891 10513-10521 NN denotes agonists
T1892 10522-10526 JJ denotes such
T1893 10527-10529 IN denotes as
T1894 10530-10543 NN denotes dexamethasone
T1895 10544-10547 CC denotes and
T1896 10548-10559 NN denotes fluticasone
T1897 10560-10570 NN denotes propionate
T1898 10571-10572 -LRB- denotes (
T1899 10572-10574 NN denotes FP
T1900 10574-10575 -RRB- denotes )
T1901 10576-10579 CC denotes and
T1902 10580-10582 IN denotes by
T1903 10583-10597 NN denotes glucocorticoid
T1904 10598-10609 NN denotes antagonists
T1905 10610-10614 JJ denotes such
T1906 10615-10617 IN denotes as
T1907 10618-10630 NN denotes mifepristone
T1908 10631-10632 -LRB- denotes (
T1909 10632-10637 NN denotes RU486
T1910 10637-10638 -RRB- denotes )
T1911 10639-10640 -LRB- denotes [
T1912 10640-10642 CD denotes 23
T1913 10642-10643 -RRB- denotes ]
T1914 10645-10648 NN denotes NL1
T1915 10649-10652 MD denotes can
T1916 10653-10655 VB denotes be
T1917 10656-10663 VB denotes mutated
T1918 10663-10664 -COMMA- denotes ,
T1919 10665-10668 CC denotes and
T1920 10669-10672 DT denotes the
T1921 10673-10682 VB denotes resulting
T1922 10683-10685 NN denotes GR
T1923 10686-10691 RB denotes still
T1924 10692-10704 VB denotes translocates
T1925 10705-10707 TO denotes to
T1926 10708-10711 DT denotes the
T1927 10712-10719 NN denotes nucleus
T1928 10720-10722 IN denotes in
T1929 10723-10731 NN denotes response
T1930 10732-10734 TO denotes to
T1931 10735-10742 NN denotes ligands
T1932 10742-10743 -COMMA- denotes ,
T1933 10744-10747 CC denotes but
T1934 10748-10751 IN denotes via
T1935 10752-10763 NN denotes interaction
T1936 10764-10768 IN denotes with
T1937 10769-10777 NN denotes importin
T1938 10778-10779 CD denotes 7
T1939 10779-10780 -COMMA- denotes ,
T1940 10781-10783 DT denotes an
T1941 10784-10789 NN denotes event
T1942 10790-10794 WDT denotes that
T1943 10795-10803 VB denotes requires
T1944 10804-10806 DT denotes an
T1945 10807-10813 JJ denotes as-yet
T1946 10814-10821 JJ denotes unknown
T1947 10822-10831 NN denotes component
T1948 10832-10833 -LRB- denotes [
T1949 10833-10835 CD denotes 23
T1950 10835-10836 -RRB- denotes ]
T1951 10838-10841 NN denotes NL2
T1952 10842-10844 VB denotes is
T1953 10845-10851 RB denotes poorly
T1954 10852-10859 VB denotes defined
T1955 10859-10860 -COMMA- denotes ,
T1956 10861-10869 VB denotes residing
T1957 10870-10872 IN denotes in
T1958 10873-10876 DT denotes the
T1959 10877-10891 JJ denotes ligand-binding
T1960 10892-10898 NN denotes domain
T1961 10898-10899 -COMMA- denotes ,
T1962 10900-10903 CC denotes and
T1963 10904-10908 RB denotes much
T1964 10909-10913 JJ denotes less
T1965 10914-10916 VB denotes is
T1966 10917-10922 VB denotes known
T1967 10923-10928 IN denotes about
T1968 10929-10932 PRP-DOLLAR- denotes its
T1969 10933-10942 NN denotes mechanism
T1970 10943-10945 IN denotes of
T1971 10946-10948 NN denotes GR
T1972 10949-10955 NN denotes import
T1973 10956-10957 -LRB- denotes [
T1974 10957-10959 CD denotes 24
T1975 10959-10960 -RRB- denotes ]
T1976 10962-10963 DT denotes A
T1977 10964-10971 NN denotes variety
T1978 10972-10974 IN denotes of
T1979 10975-10980 JJ denotes other
T1980 10981-10988 NN denotes factors
T1981 10989-10992 VB denotes are
T1982 10993-10997 RB denotes also
T1983 10998-11007 JJ denotes important
T1984 11008-11011 IN denotes for
T1985 11012-11015 DT denotes the
T1986 11016-11026 NN denotes regulation
T1987 11027-11029 IN denotes of
T1988 11030-11032 NN denotes GR
T1989 11033-11043 NN denotes activation
T1990 11044-11047 CC denotes and
T1991 11048-11055 JJ denotes nuclear
T1992 11056-11062 NN denotes import
T1993 11063-11072 VB denotes including
T1994 11073-11083 NN denotes chaperones
T1995 11084-11088 JJ denotes such
T1996 11089-11091 IN denotes as
T1997 11092-11097 NN denotes Hsp90
T1998 11098-11101 CC denotes and
T1999 11102-11107 JJ denotes other
T2000 11108-11121 NN denotes immunophilins
T2001 11122-11123 -LRB- denotes [
T2002 11123-11125 CD denotes 24
T2003 11125-11126 -RRB- denotes ]
T2004 11126-11127 CD denotes –
T2005 11127-11128 -LRB- denotes [
T2006 11128-11130 CD denotes 26
T2007 11130-11131 -RRB- denotes ]
T2008 11132-11135 CC denotes and
T2009 11136-11149 JJ denotes FK506-binding
T2010 11150-11158 NN denotes proteins
T2011 11159-11163 WDT denotes that
T2012 11164-11167 MD denotes may
T2013 11168-11170 VB denotes be
T2014 11171-11177 VB denotes linked
T2015 11178-11180 TO denotes to
T2016 11181-11187 NN denotes dynein
T2017 11188-11194 CC denotes and/or
T2018 11195-11209 JJ denotes peptidylprolyl
T2019 11210-11219 NN denotes isomerase
T2020 11220-11221 -LRB- denotes [
T2021 11221-11223 CD denotes 27
T2022 11223-11224 -RRB- denotes ]
T2023 11224-11225 -COMMA- denotes ,
T2024 11225-11226 -LRB- denotes [
T2025 11226-11228 CD denotes 28
T2026 11228-11229 -RRB- denotes ]
T2027 11231-11238 RB denotes However
T2028 11238-11239 -COMMA- denotes ,
T2029 11240-11243 DT denotes the
T2030 11244-11253 JJ denotes molecular
T2031 11254-11259 NN denotes basis
T2032 11260-11263 IN denotes for
T2033 11264-11267 DT denotes the
T2034 11268-11278 NN denotes inhibition
T2035 11279-11281 IN denotes of
T2036 11282-11285 NN denotes Th2
T2037 11286-11295 NN denotes cytokines
T2038 11296-11298 IN denotes by
T2039 11299-11314 NN denotes corticosteroids
T2040 11315-11317 VB denotes is
T2041 11318-11321 RB denotes not
T2042 11322-11326 RB denotes well
T2043 11327-11337 VB denotes understood
T2044 11337-11338 -COMMA- denotes ,
T2045 11339-11346 IN denotes because
T2046 11347-11350 DT denotes the
T2047 11351-11356 NN denotes genes
T2048 11357-11365 VB denotes encoding
T2049 11366-11370 NN denotes IL-4
T2050 11370-11371 -COMMA- denotes ,
T2051 11372-11376 NN denotes IL-5
T2052 11376-11377 -COMMA- denotes ,
T2053 11378-11381 CC denotes and
T2054 11382-11387 NN denotes IL-13
T2055 11388-11390 VB denotes do
T2056 11391-11394 RB denotes not
T2057 11395-11399 VB denotes have
T2058 11400-11403 DT denotes any
T2059 11404-11416 JJ denotes recognisable
T2060 11417-11420 NN denotes GRE
T2061 11421-11429 NN denotes sequence
T2062 11430-11431 -LRB- denotes [
T2063 11431-11433 CD denotes 29
T2064 11433-11434 -RRB- denotes ]
T2065 11435-11438 CC denotes and
T2066 11439-11442 VB denotes are
T2067 11443-11447 RB denotes only
T2068 11448-11454 RB denotes partly
T2069 11455-11464 VB denotes regulated
T2070 11465-11467 IN denotes by
T2071 11468-11473 NN denotes NF-κB
T2072 11474-11476 IN denotes in
T2073 11477-11482 JJ denotes human
T2074 11483-11488 NN denotes cells
T2075 11489-11490 -LRB- denotes [
T2076 11490-11492 CD denotes 30
T2077 11492-11493 -RRB- denotes ]
T2078 11493-11494 CD denotes –
T2079 11494-11495 -LRB- denotes [
T2080 11495-11497 CD denotes 32
T2081 11497-11498 -RRB- denotes ]
T2082 11500-11505 VB denotes Using
T2083 11506-11520 NN denotes overexpression
T2084 11521-11524 CC denotes and
T2085 11525-11537 NN denotes CAT-reporter
T2086 11538-11543 NN denotes genes
T2087 11543-11544 -COMMA- denotes ,
T2088 11545-11553 NNP denotes Lavender
T2089 11554-11557 CC denotes and
T2090 11558-11568 NN denotes colleagues
T2091 11569-11570 -LRB- denotes [
T2092 11570-11572 CD denotes 33
T2093 11572-11573 -RRB- denotes ]
T2094 11574-11578 VB denotes have
T2095 11579-11584 VB denotes shown
T2096 11585-11589 IN denotes that
T2097 11590-11592 NN denotes GR
T2098 11593-11600 VB denotes reduced
T2099 11601-11616 JJ denotes GATA-3-mediated
T2100 11617-11621 NN denotes IL-5
T2101 11622-11625 CC denotes and
T2102 11626-11629 CD denotes -13
T2103 11630-11638 NN denotes promoter
T2104 11639-11647 NN denotes activity
T2105 11648-11650 IN denotes in
T2106 11651-11656 JJ denotes human
T2107 11657-11661 JJ denotes CD4+
T2108 11662-11663 NN denotes T
T2109 11664-11669 NN denotes cells
T2110 11671-11674 DT denotes The
T2111 11675-11682 NN denotes authors
T2112 11683-11693 VB denotes postulated
T2113 11694-11698 IN denotes that
T2114 11699-11704 JJ denotes local
T2115 11705-11716 NN denotes recruitment
T2116 11717-11719 IN denotes of
T2117 11720-11722 NN denotes GR
T2118 11723-11726 MD denotes may
T2119 11727-11732 VB denotes alter
T2120 11733-11736 DT denotes the
T2121 11737-11744 NN denotes ability
T2122 11745-11747 IN denotes of
T2123 11748-11754 NN denotes GATA-3
T2124 11755-11761 CC denotes either
T2125 11762-11764 TO denotes to
T2126 11765-11769 VB denotes bind
T2127 11770-11772 TO denotes to
T2128 11773-11776 PRP-DOLLAR- denotes its
T2129 11777-11783 NN denotes target
T2130 11784-11788 NN denotes site
T2131 11788-11789 -COMMA- denotes ,
T2132 11790-11792 TO denotes to
T2133 11793-11798 VB denotes cause
T2134 11799-11814 JJ denotes transcriptional
T2135 11815-11828 NN denotes up-regulation
T2136 11828-11829 -COMMA- denotes ,
T2137 11830-11832 CC denotes or
T2138 11833-11835 TO denotes to
T2139 11836-11844 VB denotes maintain
T2140 11845-11847 DT denotes an
T2141 11848-11859 NN denotes environment
T2142 11860-11864 WDT denotes that
T2143 11865-11867 VB denotes is
T2144 11868-11878 JJ denotes permissive
T2145 11879-11882 IN denotes for
T2146 11883-11896 NN denotes transcription
T2147 11898-11900 PRP denotes We
T2148 11901-11910 RB denotes therefore
T2149 11911-11923 VB denotes investigated
T2150 11924-11927 DT denotes the
T2151 11928-11935 NN denotes effects
T2152 11936-11938 IN denotes of
T2153 11939-11940 DT denotes a
T2154 11941-11950 JJ denotes synthetic
T2155 11951-11965 NN denotes corticosteroid
T2156 11965-11966 -COMMA- denotes ,
T2157 11967-11969 NN denotes FP
T2158 11969-11970 -COMMA- denotes ,
T2159 11971-11973 IN denotes on
T2160 11974-11980 NN denotes GATA-3
T2161 11981-11996 NN denotes phosphorylation
T2162 11997-12000 CC denotes and
T2163 12001-12008 JJ denotes nuclear
T2164 12009-12022 NN denotes translocation
T2165 12023-12025 IN denotes in
T2166 12026-12027 DT denotes a
T2167 12028-12029 NN denotes T
T2168 12030-12040 NN denotes lymphocyte
T2169 12041-12045 NN denotes cell
T2170 12046-12050 NN denotes line
T2171 12051-12052 -LRB- denotes (
T2172 12052-12058 NN denotes HuT-78
T2173 12058-12059 -RRB- denotes )
T2174 12060-12063 CC denotes and
T2175 12064-12066 IN denotes in
T2176 12067-12077 JJ denotes peripheral
T2177 12078-12083 NN denotes blood
T2178 12084-12095 JJ denotes mononuclear
T2179 12096-12101 NN denotes cells
T2180 12102-12111 VB denotes activated
T2181 12112-12114 IN denotes by
T2182 12115-12123 JJ denotes anti-CD3
T2183 12124-12127 CC denotes and
T2184 12128-12137 JJ denotes anti-CD28
T2185 12138-12148 NN denotes antibodies
T2186 12149-12151 FW denotes in
T2187 12152-12157 FW denotes vitro
T2188 12159-12161 PRP denotes We
T2189 12162-12166 RB denotes also
T2190 12167-12174 VB denotes studied
T2191 12175-12178 DT denotes the
T2192 12179-12186 NN denotes effects
T2193 12187-12189 IN denotes of
T2194 12190-12197 VB denotes inhaled
T2195 12198-12209 NN denotes fluticasone
T2196 12210-12217 NN denotes therapy
T2197 12218-12220 IN denotes on
T2198 12221-12227 NN denotes GATA-3
T2199 12228-12239 JJ denotes subcellular
T2200 12240-12252 NN denotes localization
T2201 12253-12255 IN denotes in
T2202 12256-12266 JJ denotes peripheral
T2203 12267-12272 NN denotes blood
T2204 12273-12284 JJ denotes mononuclear
T2205 12285-12290 NN denotes cells
T2206 12291-12292 -LRB- denotes (
T2207 12292-12297 NN denotes PBMCs
T2208 12297-12298 -RRB- denotes )
T2209 12299-12303 IN denotes from
T2210 12304-12312 NN denotes patients
T2211 12313-12317 IN denotes with
T2212 12318-12324 NN denotes asthma
T3675 12350-12362 NN denotes Participants
T3676 12363-12366 CC denotes and
T3677 12367-12372 NN denotes Study
T3678 12373-12379 NN denotes Design
T3679 12380-12382 PRP denotes We
T3680 12383-12390 VB denotes studied
T3681 12391-12399 NN denotes patients
T3682 12400-12404 IN denotes with
T3683 12405-12409 JJ denotes mild
T3684 12410-12416 NN denotes asthma
T3685 12417-12420 WP denotes who
T3686 12421-12425 VB denotes were
T3687 12426-12429 RB denotes not
T3688 12430-12437 VB denotes treated
T3689 12438-12442 IN denotes with
T3690 12443-12450 VB denotes inhaled
T3691 12451-12466 NN denotes corticosteroids
T3692 12467-12470 WP denotes who
T3693 12471-12474 VB denotes had
T3694 12475-12479 VB denotes been
T3695 12480-12488 VB denotes included
T3696 12489-12491 IN denotes in
T3697 12492-12493 DT denotes a
T3698 12494-12504 RB denotes previously
T3699 12505-12513 VB denotes reported
T3700 12514-12526 JJ denotes double-blind
T3701 12526-12527 -COMMA- denotes ,
T3702 12528-12546 JJ denotes placebo-controlled
T3703 12546-12547 -COMMA- denotes ,
T3704 12548-12557 JJ denotes crossover
T3705 12558-12563 NN denotes study
T3706 12564-12568 IN denotes with
T3707 12569-12571 NN denotes FP
T3708 12572-12573 -LRB- denotes [
T3709 12573-12575 CD denotes 34
T3710 12575-12576 -RRB- denotes ]
T3711 12578-12583 CD denotes Seven
T3712 12584-12592 NN denotes patients
T3713 12593-12597 IN denotes with
T3714 12598-12602 JJ denotes mild
T3715 12603-12609 NN denotes asthma
T3716 12610-12617 VB denotes entered
T3717 12618-12621 DT denotes the
T3718 12622-12627 NN denotes study
T3719 12628-12631 CC denotes and
T3720 12632-12636 VB denotes were
T3721 12637-12647 VB denotes randomized
T3722 12648-12650 TO denotes to
T3723 12651-12658 VB denotes receive
T3724 12659-12660 DT denotes a
T3725 12661-12667 JJ denotes single
T3726 12668-12678 NN denotes inhalation
T3727 12679-12681 IN denotes of
T3728 12682-12684 NN denotes FP
T3729 12685-12686 -LRB- denotes (
T3730 12686-12689 CD denotes 100
T3731 12690-12693 CC denotes and
T3732 12694-12697 CD denotes 500
T3733 12698-12700 NN denotes µg
T3734 12700-12701 -RRB- denotes )
T3735 12702-12704 CC denotes or
T3736 12705-12706 DT denotes a
T3737 12707-12714 JJ denotes matched
T3738 12715-12722 NN denotes placebo
T3739 12723-12730 NN denotes control
T3740 12731-12734 IN denotes via
T3741 12735-12736 DT denotes a
T3742 12737-12743 NN denotes spacer
T3743 12744-12751 NN denotes chamber
T3744 12751-12752 -COMMA- denotes ,
T3745 12753-12756 CC denotes and
T3746 12757-12760 DT denotes the
T3747 12761-12766 JJ denotes other
T3748 12767-12776 NN denotes treatment
T3749 12777-12780 VB denotes was
T3750 12781-12786 VB denotes given
T3751 12787-12792 IN denotes after
T3752 12793-12794 DT denotes a
T3753 12795-12803 JJ denotes wash-out
T3754 12804-12810 NN denotes period
T3755 12811-12813 IN denotes of
T3756 12814-12816 IN denotes at
T3757 12817-12822 JJ denotes least
T3758 12823-12824 CD denotes 6
T3759 12825-12826 NN denotes d
T3760 12828-12833 NN denotes Blood
T3761 12834-12837 VB denotes was
T3762 12838-12843 VB denotes taken
T3763 12844-12847 IN denotes for
T3764 12848-12859 NN denotes preparation
T3765 12860-12862 IN denotes of
T3766 12863-12868 NN denotes PBMCs
T3767 12869-12871 IN denotes at
T3768 12872-12873 CD denotes 1
T3769 12874-12877 CC denotes and
T3770 12878-12879 CD denotes 2
T3771 12880-12881 NN denotes h
T3772 12882-12887 IN denotes after
T3773 12888-12892 NN denotes drug
T3774 12893-12907 NN denotes administration
T3775 12909-12912 DT denotes All
T3776 12913-12921 NN denotes patients
T3777 12922-12926 VB denotes gave
T3778 12927-12935 VB denotes informed
T3779 12936-12943 NN denotes consent
T3780 12944-12947 CC denotes and
T3781 12948-12951 DT denotes the
T3782 12952-12957 NN denotes study
T3783 12958-12961 VB denotes was
T3784 12962-12970 VB denotes approved
T3785 12971-12973 IN denotes by
T3786 12974-12977 DT denotes the
T3787 12978-12984 NNP denotes Ethics
T3788 12985-12994 NNP denotes Committee
T3789 12995-12997 IN denotes of
T3790 12998-13001 DT denotes the
T3791 13002-13007 NNP denotes Royal
T3792 13008-13016 NNP denotes Brompton
T3793 13017-13020 CC denotes and
T3794 13021-13030 NNP denotes Harefield
T3795 13031-13040 NNP denotes Hospitals
T3796 13041-13044 NNP denotes NHS
T3797 13045-13051 NNP denotes Trust.
T3798 13052-13055 DT denotes The
T3799 13056-13064 JJ denotes clinical
T3800 13065-13070 NN denotes study
T3801 13071-13074 VB denotes was
T3802 13075-13084 VB denotes conducted
T3803 13085-13091 IN denotes before
T3804 13092-13095 DT denotes the
T3805 13096-13107 NN denotes requirement
T3806 13108-13111 IN denotes for
T3807 13112-13120 NNP denotes Clinical
T3808 13121-13126 NNP denotes Trial
T3809 13127-13139 NNP denotes Registration
T3981 13142-13152 NN denotes Antibodies
T3982 13153-13156 CC denotes and
T3983 13157-13165 NN denotes Reagents
T3984 13166-13169 DT denotes The
T3985 13170-13180 JJ denotes monoclonal
T3986 13181-13191 NN denotes antibodies
T3987 13192-13199 IN denotes against
T3988 13200-13205 JJ denotes human
T3989 13206-13209 NN denotes CD3
T3990 13209-13210 -COMMA- denotes ,
T3991 13211-13215 NN denotes CD28
T3992 13215-13216 -COMMA- denotes ,
T3993 13217-13219 NN denotes GR
T3994 13219-13220 -COMMA- denotes ,
T3995 13221-13224 CC denotes and
T3996 13225-13235 NN denotes importin-α
T3997 13236-13240 VB denotes were
T3998 13241-13250 VB denotes purchased
T3999 13251-13255 IN denotes from
T4000 13256-13258 NN denotes BD
T4001 13259-13270 NNP denotes Biosciences
T4002 13271-13272 -LRB- denotes (
T4003 13272-13278 NNP denotes Oxford
T4004 13278-13279 -COMMA- denotes ,
T4005 13280-13286 NNP denotes United
T4006 13287-13294 NNP denotes Kingdom
T4007 13294-13295 -RRB- denotes )
T4008 13297-13303 NN denotes Rabbit
T4009 13304-13314 NN denotes antibodies
T4010 13315-13322 IN denotes against
T4011 13323-13328 JJ denotes human
T4012 13329-13335 NN denotes GATA-3
T4013 13336-13337 -LRB- denotes (
T4014 13337-13341 NN denotes H-48
T4015 13341-13342 -RRB- denotes )
T4016 13343-13346 CC denotes and
T4017 13347-13349 NN denotes GR
T4018 13350-13351 -LRB- denotes (
T4019 13351-13355 NN denotes E-20
T4020 13355-13356 -COMMA- denotes ,
T4021 13357-13364 NN denotes sc-1003
T4022 13364-13365 -RRB- denotes )
T4023 13366-13370 VB denotes were
T4024 13371-13379 VB denotes obtained
T4025 13380-13384 IN denotes from
T4026 13385-13390 NNP denotes Santa
T4027 13391-13395 NNP denotes Cruz
T4028 13396-13409 NNP denotes Biotechnology
T4029 13410-13411 -LRB- denotes (
T4030 13411-13416 NNP denotes Santa
T4031 13417-13421 NNP denotes Cruz
T4032 13421-13422 -COMMA- denotes ,
T4033 13423-13433 NNP denotes California
T4034 13433-13434 -COMMA- denotes ,
T4035 13435-13441 NNP denotes United
T4036 13442-13448 NNP denotes States
T4037 13448-13449 -RRB- denotes )
T4038 13449-13450 -COMMA- denotes ,
T4039 13451-13461 JJ denotes polyclonal
T4040 13462-13468 NN denotes rabbit
T4041 13469-13479 NN denotes antibodies
T4042 13480-13487 IN denotes against
T4043 13488-13499 JJ denotes phospho-p38
T4044 13500-13503 NN denotes MAP
T4045 13504-13510 NN denotes kinase
T4046 13511-13514 CC denotes and
T4047 13515-13528 NN denotes phospho-ATF-2
T4048 13529-13533 IN denotes from
T4049 13534-13538 NNP denotes Cell
T4050 13539-13548 NNP denotes Signaling
T4051 13549-13559 NNP denotes Technology
T4052 13560-13561 -LRB- denotes (
T4053 13561-13564 NNP denotes New
T4054 13565-13572 NNP denotes England
T4055 13573-13580 NNP denotes Biolabs
T4056 13580-13581 -COMMA- denotes ,
T4057 13582-13590 NNP denotes Hertford
T4058 13590-13591 -COMMA- denotes ,
T4059 13592-13594 NNP denotes UK
T4060 13594-13595 -RRB- denotes )
T4061 13595-13596 -COMMA- denotes ,
T4062 13597-13607 JJ denotes monoclonal
T4063 13608-13616 NN denotes antibody
T4064 13617-13624 IN denotes against
T4065 13625-13638 NN denotes phosphoserine
T4066 13639-13640 -LRB- denotes (
T4067 13640-13645 NN denotes clone
T4068 13646-13649 NN denotes 4H4
T4069 13649-13650 -RRB- denotes )
T4070 13651-13655 IN denotes from
T4071 13656-13664 NNP denotes Affiniti
T4072 13665-13673 NNP denotes Research
T4073 13674-13682 NNP denotes Products
T4074 13683-13684 -LRB- denotes (
T4075 13684-13690 NNP denotes Exeter
T4076 13690-13691 -COMMA- denotes ,
T4077 13692-13694 NNP denotes UK
T4078 13694-13695 -RRB- denotes )
T4079 13695-13696 -COMMA- denotes ,
T4080 13697-13700 CC denotes and
T4081 13701-13711 NN denotes antibodies
T4082 13712-13719 IN denotes against
T4083 13720-13726 NN denotes rabbit
T4084 13727-13741 JJ denotes IgG-conjugated
T4085 13742-13747 NN denotes TRITC
T4086 13748-13752 IN denotes from
T4087 13753-13757 NNP denotes Dako
T4088 13758-13768 NNP denotes Cytomation
T4089 13769-13770 -LRB- denotes (
T4090 13770-13779 NNP denotes Cambridge
T4091 13779-13780 -COMMA- denotes ,
T4092 13781-13783 NNP denotes UK
T4093 13783-13784 -RRB- denotes )
T4094 13786-13789 DT denotes The
T4095 13790-13797 JJ denotes anti-GR
T4096 13798-13806 NN denotes antibody
T4097 13807-13808 -LRB- denotes (
T4098 13808-13813 NN denotes Clone
T4099 13814-13816 CD denotes 41
T4100 13816-13817 -RRB- denotes )
T4101 13818-13822 IN denotes from
T4102 13823-13825 NN denotes BD
T4103 13826-13838 NN denotes Transduction
T4104 13839-13851 NN denotes Laboratories
T4105 13852-13853 -LRB- denotes (
T4106 13853-13859 NNP denotes Oxford
T4107 13859-13860 -COMMA- denotes ,
T4108 13861-13863 NNP denotes UK
T4109 13863-13864 -RRB- denotes )
T4110 13865-13868 VB denotes was
T4111 13869-13873 VB denotes used
T4112 13874-13877 IN denotes for
T4113 13878-13885 JJ denotes Western
T4114 13886-13890 NN denotes blot
T4115 13891-13899 NN denotes analysis
T4116 13901-13904 DT denotes All
T4117 13905-13910 JJ denotes other
T4118 13911-13919 NN denotes reagents
T4119 13920-13924 VB denotes were
T4120 13925-13934 VB denotes purchased
T4121 13935-13939 IN denotes from
T4122 13940-13945 NN denotes Sigma
T4123 13946-13947 -LRB- denotes (
T4124 13947-13952 NN denotes Poole
T4125 13952-13953 -COMMA- denotes ,
T4126 13954-13956 NNP denotes UK
T4127 13956-13957 -RRB- denotes )
T4354 13960-13964 NN denotes Cell
T4355 13965-13972 NN denotes Culture
T4356 13973-13976 CC denotes and
T4357 13977-13981 NN denotes PBMC
T4358 13982-13991 NN denotes Isolation
T4359 13992-13993 DT denotes A
T4360 13994-13999 JJ denotes human
T4361 14000-14001 NN denotes T
T4362 14002-14006 NN denotes cell
T4363 14007-14011 NN denotes line
T4364 14012-14013 -LRB- denotes (
T4365 14013-14019 NN denotes HuT-78
T4366 14019-14020 -RRB- denotes )
T4367 14021-14024 VB denotes was
T4368 14025-14034 VB denotes purchased
T4369 14035-14039 IN denotes from
T4370 14040-14045 NN denotes ECACC
T4371 14046-14054 NNP denotes European
T4372 14055-14065 NNP denotes Collection
T4373 14066-14068 IN denotes of
T4374 14069-14073 NNP denotes Cell
T4375 14074-14081 NNP denotes Culture
T4376 14082-14083 -LRB- denotes (
T4377 14083-14092 NNP denotes Wiltshire
T4378 14092-14093 -COMMA- denotes ,
T4379 14094-14096 NNP denotes UK
T4380 14096-14097 -RRB- denotes )
T4381 14098-14102 VB denotes were
T4382 14103-14111 VB denotes cultured
T4383 14112-14114 IN denotes as
T4384 14115-14125 RB denotes previously
T4385 14126-14135 VB denotes described
T4386 14136-14137 -LRB- denotes [
T4387 14137-14139 CD denotes 12
T4388 14139-14140 -RRB- denotes ]
T4389 14142-14147 NN denotes PBMCs
T4390 14148-14152 VB denotes were
T4391 14153-14161 VB denotes isolated
T4392 14162-14164 IN denotes by
T4393 14165-14172 NN denotes density
T4394 14173-14187 NN denotes centrifugation
T4395 14188-14192 IN denotes over
T4396 14193-14207 JJ denotes Ficoll-Hypaque
T4397 14208-14209 -LRB- denotes (
T4398 14209-14216 NN denotes density
T4399 14216-14217 -COMMA- denotes ,
T4400 14218-14223 CD denotes 1.077
T4401 14224-14228 NN denotes g/ml
T4402 14228-14229 -COLON- denotes ;
T4403 14230-14238 NNP denotes Amersham
T4404 14239-14250 NNP denotes Biosciences
T4405 14250-14251 -COMMA- denotes ,
T4406 14252-14260 NNP denotes Amersham
T4407 14260-14261 -COMMA- denotes ,
T4408 14262-14264 NNP denotes UK
T4409 14264-14265 -RRB- denotes )
T4410 14266-14268 IN denotes as
T4411 14269-14279 RB denotes previously
T4412 14280-14289 VB denotes described
T4413 14290-14291 -LRB- denotes [
T4414 14291-14293 CD denotes 34
T4415 14293-14294 -RRB- denotes ]
T4416 14296-14301 NN denotes Cells
T4417 14302-14306 VB denotes were
T4418 14307-14317 VB denotes stimulated
T4419 14318-14322 IN denotes with
T4420 14323-14336 JJ denotes anti-CD3/CD28
T4421 14337-14338 -LRB- denotes (
T4422 14338-14339 CD denotes 1
T4423 14340-14345 NN denotes µg/ml
T4424 14346-14350 DT denotes each
T4425 14350-14351 -RRB- denotes )
T4426 14352-14355 IN denotes for
T4427 14356-14357 CD denotes 1
T4428 14358-14359 NN denotes h
T4429 14360-14362 IN denotes at
T4430 14363-14367 NN denotes 37°C
T4431 14368-14370 TO denotes to
T4432 14371-14380 VB denotes stimulate
T4433 14381-14384 NN denotes Th2
T4434 14385-14393 NN denotes cytokine
T4435 14394-14401 NN denotes release
T4436 14402-14404 IN denotes in
T4437 14405-14408 DT denotes the
T4438 14409-14417 NN denotes presence
T4439 14418-14420 CC denotes or
T4440 14421-14428 NN denotes absence
T4441 14429-14431 IN denotes of
T4442 14432-14434 NN denotes FP
T4443 14435-14436 -LRB- denotes (
T4444 14436-14441 CD denotes 10−12
T4445 14442-14444 TO denotes to
T4446 14445-14450 NN denotes 10−8M
T4447 14450-14451 -RRB- denotes )
T4448 14453-14462 NN denotes Cytospins
T4449 14463-14467 VB denotes were
T4450 14468-14476 VB denotes prepared
T4451 14477-14480 CC denotes and
T4452 14481-14487 NN denotes GATA-3
T4453 14488-14500 NN denotes localization
T4454 14501-14511 VB denotes determined
T4455 14512-14514 IN denotes by
T4456 14515-14523 JJ denotes confocal
T4457 14524-14534 NN denotes microscopy
T4458 14535-14537 IN denotes as
T4459 14538-14548 RB denotes previously
T4460 14549-14558 VB denotes described
T4461 14559-14560 -LRB- denotes [
T4462 14560-14562 CD denotes 12
T4463 14562-14563 -RRB- denotes ]
T4622 14566-14573 JJ denotes Reverse
T4623 14574-14587 NN denotes Transcription
T4624 14588-14591 NN denotes PCR
T4625 14592-14597 JJ denotes Total
T4626 14598-14601 NN denotes RNA
T4627 14602-14605 VB denotes was
T4628 14606-14615 VB denotes extracted
T4629 14616-14621 VB denotes using
T4630 14622-14627 NN denotes lysis
T4631 14628-14634 NN denotes buffer
T4632 14635-14636 -LRB- denotes (
T4633 14636-14642 NN denotes RNeasy
T4634 14643-14646 NN denotes kit
T4635 14646-14647 -COLON- denotes ;
T4636 14648-14654 NNP denotes Qiagen
T4637 14654-14655 -COMMA- denotes ,
T4638 14656-14663 NNP denotes Crawley
T4639 14663-14664 -COMMA- denotes ,
T4640 14665-14667 NNP denotes UK
T4641 14667-14668 -RRB- denotes )
T4642 14670-14676 IN denotes During
T4643 14677-14680 NN denotes RNA
T4644 14681-14693 NN denotes purification
T4645 14693-14694 -COMMA- denotes ,
T4646 14695-14702 JJ denotes genomic
T4647 14703-14706 NN denotes DNA
T4648 14707-14710 VB denotes was
T4649 14711-14719 VB denotes digested
T4650 14720-14724 IN denotes with
T4651 14725-14735 JJ denotes RNase-free
T4652 14736-14741 NN denotes DNase
T4653 14742-14743 -LRB- denotes (
T4654 14743-14751 NNP denotes Amersham
T4655 14752-14763 NNP denotes Biosciences
T4656 14763-14764 -RRB- denotes )
T4657 14766-14770 RB denotes Next
T4658 14770-14771 -COMMA- denotes ,
T4659 14772-14775 CD denotes 0.5
T4660 14776-14778 NN denotes µg
T4661 14779-14781 IN denotes of
T4662 14782-14787 JJ denotes total
T4663 14788-14791 NN denotes RNA
T4664 14792-14795 VB denotes was
T4665 14796-14804 VB denotes reversed
T4666 14805-14816 VB denotes transcribed
T4667 14817-14822 VB denotes using
T4668 14823-14826 DT denotes the
T4669 14827-14832 JJ denotes avian
T4670 14833-14847 NN denotes myeloblastosis
T4671 14848-14853 NN denotes virus
T4672 14854-14856 NN denotes RT
T4673 14857-14858 -LRB- denotes (
T4674 14858-14865 NNP denotes Promega
T4675 14865-14866 -COMMA- denotes ,
T4676 14867-14878 NNP denotes Southampton
T4677 14878-14879 -COMMA- denotes ,
T4678 14880-14882 NNP denotes UK
T4679 14882-14883 -RRB- denotes )
T4680 14885-14888 IN denotes For
T4681 14889-14897 JJ denotes relative
T4682 14898-14912 NN denotes quantification
T4683 14912-14913 -COMMA- denotes ,
T4684 14914-14920 NN denotes RT-PCR
T4685 14921-14924 VB denotes was
T4686 14925-14932 VB denotes carried
T4687 14933-14936 RP denotes out
T4688 14937-14942 VB denotes using
T4689 14943-14947 NN denotes cDNA
T4690 14948-14954 NN denotes probes
T4691 14956-14963 NN denotes Primers
T4692 14964-14967 IN denotes for
T4693 14968-14972 NN denotes IL-4
T4694 14973-14977 VB denotes were
T4695 14978-14982 IN denotes from
T4696 14983-14996 NN denotes Sigma-Genosys
T4697 14997-14998 -LRB- denotes (
T4698 14998-15007 NNP denotes Cambridge
T4699 15007-15008 -COMMA- denotes ,
T4700 15009-15011 NNP denotes UK
T4701 15011-15012 -RRB- denotes )
T4702 15014-15023 NN denotes Sequences
T4703 15024-15026 IN denotes of
T4704 15027-15032 NN denotes GADPH
T4705 15033-15037 VB denotes used
T4706 15038-15041 VB denotes are
T4707 15042-15044 IN denotes as
T4708 15045-15052 VB denotes follows
T4709 15052-15053 -COLON- denotes :
T4710 15054-15061 RB denotes forward
T4711 15062-15088 NN denotes 5′-CCACCCATGGCAAATTCCATGGC
T4712 15088-15089 -COMMA- denotes ,
T4713 15090-15097 JJ denotes reverse
T4714 15098-15124 NN denotes 3′-TCTAGACGGCAGGTCAGGTCCAC
T4853 15127-15131 NNP denotes Cell
T4854 15132-15145 NNP denotes Fractionation
T4855 15145-15146 -COMMA- denotes ,
T4856 15147-15166 NN denotes Immunoprecipitation
T4857 15166-15167 -COMMA- denotes ,
T4858 15168-15171 CC denotes and
T4859 15172-15179 NNP denotes Western
T4860 15180-15184 NNP denotes Blot
T4861 15185-15193 NN denotes Analysis
T4862 15194-15201 JJ denotes Nuclear
T4863 15202-15205 CC denotes and
T4864 15206-15217 JJ denotes cytoplasmic
T4865 15218-15227 NN denotes fractions
T4866 15228-15232 VB denotes were
T4867 15233-15241 VB denotes prepared
T4868 15242-15244 IN denotes as
T4869 15245-15255 RB denotes previously
T4870 15256-15265 VB denotes described
T4871 15266-15267 -LRB- denotes [
T4872 15267-15269 CD denotes 35
T4873 15269-15270 -RRB- denotes ]
T4874 15272-15277 JJ denotes Whole
T4875 15278-15282 NN denotes cell
T4876 15283-15290 NN denotes lysates
T4877 15291-15295 VB denotes were
T4878 15296-15304 VB denotes prepared
T4879 15305-15307 IN denotes in
T4880 15308-15313 NN denotes NP-40
T4881 15314-15319 NN denotes lysis
T4882 15320-15326 NN denotes buffer
T4883 15327-15328 -LRB- denotes (
T4884 15328-15331 CD denotes 0.5
T4885 15331-15332 NN denotes %
T4886 15333-15340 NN denotes Nonidet
T4887 15341-15345 NN denotes P-40
T4888 15345-15346 -COMMA- denotes ,
T4889 15347-15349 CD denotes 20
T4890 15350-15352 NN denotes mM
T4891 15353-15361 NN denotes Tris-HCl
T4892 15362-15363 -LRB- denotes [
T4893 15363-15365 NN denotes pH
T4894 15366-15369 CD denotes 7.5
T4895 15369-15370 -RRB- denotes ]
T4896 15370-15371 -COMMA- denotes ,
T4897 15372-15375 CD denotes 150
T4898 15376-15378 NN denotes mM
T4899 15379-15383 NN denotes NaCl
T4900 15383-15384 -RRB- denotes )
T4901 15385-15387 IN denotes in
T4902 15388-15391 DT denotes the
T4903 15392-15400 NN denotes presence
T4904 15401-15403 IN denotes of
T4905 15404-15412 JJ denotes complete
T4906 15413-15421 NN denotes protease
T4907 15422-15430 NN denotes cocktail
T4908 15431-15440 NN denotes inhibitor
T4909 15442-15449 NN denotes Lysates
T4910 15450-15454 VB denotes were
T4911 15455-15466 VB denotes centrifuged
T4912 15467-15469 IN denotes at
T4913 15470-15473 NN denotes 4°C
T4914 15474-15477 IN denotes for
T4915 15478-15480 CD denotes 10
T4916 15481-15484 NN denotes min
T4917 15485-15487 IN denotes at
T4918 15488-15494 CD denotes 12,000
T4919 15495-15498 NN denotes rpm
T4920 15499-15501 IN denotes in
T4921 15502-15504 DT denotes an
T4922 15505-15514 NNP denotes Eppendorf
T4923 15515-15530 NN denotes microcentrifuge
T4924 15531-15533 TO denotes to
T4925 15534-15540 VB denotes remove
T4926 15541-15549 JJ denotes cellular
T4927 15550-15556 NN denotes debris
T4928 15558-15565 NN denotes Samples
T4929 15566-15570 VB denotes were
T4930 15571-15575 RB denotes then
T4931 15576-15594 VB denotes immunoprecipitated
T4932 15595-15599 IN denotes with
T4933 15600-15606 CC denotes either
T4934 15607-15609 CD denotes 10
T4935 15610-15612 NN denotes µl
T4936 15613-15615 IN denotes of
T4937 15616-15624 NN denotes antibody
T4938 15625-15632 IN denotes against
T4939 15633-15639 NN denotes GATA-3
T4940 15640-15642 CC denotes or
T4941 15643-15653 NN denotes importin-α
T4942 15654-15659 VB denotes using
T4943 15660-15663 NN denotes A/G
T4944 15664-15671 VB denotes agarose
T4945 15672-15678 NN denotes slurry
T4946 15679-15681 IN denotes in
T4947 15682-15685 DT denotes the
T4948 15686-15694 NN denotes presence
T4949 15695-15697 IN denotes of
T4950 15698-15706 NN denotes protease
T4951 15707-15716 NN denotes inhibitor
T4952 15717-15722 VB denotes using
T4953 15723-15726 DT denotes the
T4954 15727-15732 NNP denotes Catch
T4955 15733-15736 CC denotes and
T4956 15737-15744 NN denotes Release
T4957 15745-15756 NN denotes methodology
T4958 15757-15758 -LRB- denotes (
T4959 15758-15765 NNP denotes Upstate
T4960 15766-15779 NNP denotes Biotechnology
T4961 15779-15780 -COMMA- denotes ,
T4962 15781-15785 NNP denotes Lake
T4963 15786-15792 NNP denotes Placid
T4964 15792-15793 -COMMA- denotes ,
T4965 15794-15797 NNP denotes New
T4966 15798-15802 NNP denotes York
T4967 15802-15803 -COMMA- denotes ,
T4968 15804-15807 NNP denotes USA
T4969 15807-15808 -RRB- denotes )
T4970 15810-15817 NN denotes Western
T4971 15818-15822 NN denotes blot
T4972 15823-15831 NN denotes analysis
T4973 15832-15835 VB denotes was
T4974 15836-15845 VB denotes performed
T4975 15846-15851 VB denotes using
T4976 15852-15863 NN denotes anti-GATA-3
T4977 15863-15864 -COMMA- denotes ,
T4978 15865-15880 JJ denotes anti-importin-α
T4979 15880-15881 -COMMA- denotes ,
T4980 15882-15889 JJ denotes anti-GR
T4981 15889-15890 -COMMA- denotes ,
T4982 15891-15901 JJ denotes anti-p-p38
T4983 15902-15905 NN denotes MAP
T4984 15906-15912 NN denotes kinase
T4985 15912-15913 -COMMA- denotes ,
T4986 15914-15926 NN denotes anti-p-ATF-2
T4987 15926-15927 -COMMA- denotes ,
T4988 15928-15931 CC denotes and
T4989 15932-15945 JJ denotes anti-p-serine
T4990 15947-15961 JJ denotes Immunoreactive
T4991 15962-15970 NN denotes proteins
T4992 15971-15975 VB denotes were
T4993 15976-15984 VB denotes detected
T4994 15985-15990 VB denotes using
T4995 15991-15993 DT denotes an
T4996 15994-16002 VB denotes enhanced
T4997 16003-16020 NN denotes chemiluminescence
T4998 16021-16024 NN denotes ECL
T4999 16025-16028 NN denotes kit
T5000 16029-16030 -LRB- denotes (
T5001 16030-16038 NNP denotes Amersham
T5002 16039-16050 NNP denotes Biosciences
T5003 16050-16051 -RRB- denotes )
T5206 16054-16063 NN denotes Chromatin
T5207 16064-16083 NN denotes Immunoprecipitation
T5208 16084-16093 NN denotes Chromatin
T5209 16094-16113 NN denotes immunoprecipitation
T5210 16114-16115 -LRB- denotes (
T5211 16115-16117 NN denotes IP
T5212 16117-16118 -RRB- denotes )
T5213 16119-16122 VB denotes was
T5214 16123-16132 VB denotes performed
T5215 16133-16135 IN denotes as
T5216 16136-16146 RB denotes previously
T5217 16147-16156 VB denotes described
T5218 16157-16158 -LRB- denotes [
T5219 16158-16160 CD denotes 12
T5220 16160-16161 -RRB- denotes ]
T5221 16162-16164 IN denotes in
T5222 16165-16171 JJ denotes HuT-78
T5223 16172-16179 NN denotes T-cells
T5224 16180-16184 IN denotes with
T5225 16185-16186 CD denotes 2
T5226 16187-16189 NN denotes µg
T5227 16190-16192 IN denotes of
T5228 16193-16204 NN denotes anti-GATA-3
T5229 16205-16206 -LRB- denotes (
T5230 16206-16211 NNP denotes Santa
T5231 16212-16216 NNP denotes Cruz
T5232 16217-16230 NNP denotes Biotechnology
T5233 16230-16231 -RRB- denotes )
T5234 16231-16232 -COMMA- denotes ,
T5235 16233-16235 CC denotes or
T5236 16236-16244 JJ denotes isotypic
T5237 16245-16259 NN denotes immunoglobulin
T5238 16260-16261 NN denotes G
T5239 16262-16264 IN denotes as
T5240 16265-16266 DT denotes a
T5241 16267-16279 JJ denotes non-specific
T5242 16280-16287 NN denotes control
T5243 16288-16289 -LRB- denotes (
T5244 16289-16294 NNP denotes Santa
T5245 16295-16299 NNP denotes Cruz
T5246 16300-16313 NNP denotes Biotechnology
T5247 16313-16314 -RRB- denotes )
T5248 16315-16324 RB denotes overnight
T5249 16325-16327 IN denotes at
T5250 16328-16332 NNP denotes 4°C.
T5251 16333-16341 NNP denotes Promoter
T5252 16342-16351 NN denotes sequences
T5253 16352-16356 VB denotes were
T5254 16357-16365 VB denotes detected
T5255 16366-16370 IN denotes with
T5256 16371-16374 NN denotes PCR
T5257 16375-16382 NN denotes primers
T5258 16383-16386 IN denotes for
T5259 16387-16390 DT denotes the
T5260 16391-16395 NN denotes IL-5
T5261 16396-16404 NN denotes promoter
T5262 16405-16406 -LRB- denotes (
T5263 16406-16410 CD denotes −445
T5264 16411-16413 TO denotes to
T5265 16414-16416 CD denotes +4
T5266 16416-16417 -RRB- denotes )
T5267 16417-16418 -COLON- denotes :
T5268 16419-16426 JJ denotes forward
T5269 16427-16454 NN denotes 5′-TTAATCTAGCCACAGTCATAG-3′
T5270 16455-16458 CC denotes and
T5271 16459-16466 VB denotes reverse
T5272 16466-16467 -COLON- denotes :
T5273 16468-16495 NN denotes 5′-TCATGGCTCTGAAACGTTCTG-3′
T5274 16497-16500 NN denotes PCR
T5275 16501-16504 VB denotes was
T5276 16505-16514 VB denotes performed
T5277 16515-16520 VB denotes using
T5278 16521-16522 DT denotes a
T5279 16523-16529 NNP denotes Hybaid
T5280 16530-16538 NNP denotes Omnigene
T5281 16539-16546 JJ denotes thermal
T5282 16547-16553 NN denotes cycler
T5283 16554-16555 -LRB- denotes (
T5284 16555-16561 NNP denotes Hybaid
T5285 16561-16562 -COMMA- denotes ,
T5286 16563-16570 NNP denotes Ashford
T5287 16570-16571 -COMMA- denotes ,
T5288 16572-16574 NNP denotes UK
T5289 16574-16575 -RRB- denotes )
T5290 16576-16580 IN denotes with
T5291 16581-16588 VB denotes cycling
T5292 16589-16599 NN denotes parameters
T5293 16600-16602 IN denotes of
T5294 16603-16607 NN denotes 72°C
T5295 16608-16611 IN denotes for
T5296 16612-16614 CD denotes 10
T5297 16615-16618 NN denotes min
T5298 16618-16619 -COMMA- denotes ,
T5301 16630-16632 IN denotes at
T5302 16633-16637 NN denotes 94°C
T5303 16638-16641 IN denotes for
T5304 16642-16644 CD denotes 45
T5305 16645-16646 NN denotes s
T5306 16646-16647 -COMMA- denotes ,
T5307 16648-16652 NN denotes 52°C
T5308 16653-16656 IN denotes for
T5309 16657-16659 CD denotes 45
T5310 16660-16661 NN denotes s
T5311 16661-16662 -COMMA- denotes ,
T5312 16663-16667 NN denotes 72°C
T5313 16668-16671 IN denotes for
T5314 16672-16674 CD denotes 45
T5315 16675-16676 NN denotes s
T5499 16679-16688 NN denotes GR-GATA-3
T5500 16689-16691 IN denotes In
T5501 16692-16697 NNP denotes Vitro
T5502 16698-16709 NNP denotes Competition
T5503 16710-16715 NNP denotes Assay
T5504 16716-16719 IN denotes for
T5505 16720-16730 NNP denotes Importin-α
T5506 16731-16732 -LRB- denotes (
T5507 16732-16743 JJ denotes Far-Western
T5508 16744-16749 NN denotes ELISA
T5509 16749-16750 -RRB- denotes )
T5510 16751-16769 VB denotes Immunoprecipitated
T5511 16770-16780 JJ denotes importin-α
T5512 16781-16782 -LRB- denotes (
T5513 16782-16797 JJ denotes anti-importin-α
T5514 16797-16798 -COMMA- denotes ,
T5515 16799-16804 NNP denotes Santa
T5516 16805-16809 NNP denotes Cruz
T5517 16810-16823 NNP denotes Biotechnology
T5518 16823-16824 -RRB- denotes )
T5519 16825-16829 IN denotes from
T5520 16830-16836 NN denotes HuT-78
T5521 16837-16842 NN denotes cells
T5522 16843-16846 VB denotes was
T5523 16847-16856 VB denotes separated
T5524 16857-16859 IN denotes by
T5525 16860-16868 NN denotes SDS-PAGE
T5526 16869-16872 CC denotes and
T5527 16873-16881 VB denotes purified
T5528 16882-16886 IN denotes from
T5529 16887-16890 DT denotes the
T5530 16891-16898 VB denotes excised
T5531 16899-16902 NN denotes gel
T5532 16903-16905 IN denotes by
T5533 16906-16920 NN denotes electroelution
T5534 16921-16922 -LRB- denotes [
T5535 16922-16924 CD denotes 36
T5536 16924-16925 -RRB- denotes ]
T5537 16927-16936 RB denotes Similarly
T5538 16936-16937 -COMMA- denotes ,
T5539 16938-16944 NN denotes GATA-3
T5540 16945-16948 VB denotes was
T5541 16949-16957 VB denotes isolated
T5542 16958-16962 IN denotes from
T5543 16963-16976 JJ denotes nonstimulated
T5544 16977-16983 NN denotes HuT-78
T5545 16984-16989 NN denotes cells
T5546 16990-16992 CC denotes or
T5547 16993-16998 NN denotes cells
T5548 16999-17009 VB denotes stimulated
T5549 17010-17013 IN denotes for
T5550 17014-17016 CD denotes 30
T5551 17017-17020 NN denotes min
T5552 17021-17025 IN denotes with
T5553 17026-17039 JJ denotes anti-CD3/CD28
T5554 17040-17043 CC denotes and
T5555 17044-17046 NN denotes GR
T5556 17047-17050 VB denotes was
T5557 17051-17059 VB denotes isolated
T5558 17060-17064 IN denotes from
T5559 17065-17067 NN denotes FP
T5560 17068-17069 -LRB- denotes (
T5561 17069-17073 CD denotes 10−8
T5562 17074-17075 NN denotes M
T5563 17075-17076 -COMMA- denotes ,
T5564 17077-17079 CD denotes 30
T5565 17080-17083 NN denotes min
T5566 17083-17084 -RRB- denotes )
T5567 17085-17095 VB denotes stimulated
T5568 17096-17102 NN denotes HuT-78
T5569 17103-17108 NN denotes cells
T5570 17110-17115 DT denotes These
T5571 17116-17124 NN denotes proteins
T5572 17125-17129 VB denotes were
T5573 17130-17142 RB denotes subsequently
T5574 17143-17151 VB denotes refolded
T5575 17152-17154 IN denotes in
T5576 17155-17162 NN denotes glycine
T5577 17163-17171 NN denotes solution
T5578 17173-17176 CD denotes 100
T5579 17177-17179 NN denotes µl
T5580 17180-17182 IN denotes of
T5581 17183-17193 JJ denotes importin-α
T5582 17194-17202 NN denotes solution
T5583 17203-17204 -LRB- denotes (
T5584 17204-17207 CD denotes 100
T5585 17208-17213 NN denotes ng/ml
T5586 17214-17216 IN denotes in
T5587 17217-17220 NN denotes TBS
T5588 17220-17221 -RRB- denotes )
T5589 17222-17225 VB denotes was
T5590 17226-17231 VB denotes added
T5591 17232-17234 TO denotes to
T5592 17235-17242 JJ denotes 96-well
T5593 17243-17249 NN denotes plates
T5594 17250-17256 VB denotes coated
T5595 17257-17261 IN denotes with
T5596 17262-17266 NN denotes goat
T5597 17267-17282 JJ denotes anti-importin-α
T5598 17283-17291 NN denotes antibody
T5599 17293-17298 IN denotes After
T5600 17299-17300 CD denotes 1
T5601 17301-17302 NN denotes h
T5602 17303-17313 NN denotes incubation
T5603 17313-17314 -COMMA- denotes ,
T5604 17315-17321 NN denotes GATA-3
T5605 17322-17323 -LRB- denotes (
T5606 17323-17326 CD denotes 100
T5607 17327-17332 NN denotes ng/ml
T5608 17333-17335 IN denotes in
T5609 17336-17339 NN denotes TBS
T5610 17339-17340 -RRB- denotes )
T5611 17341-17345 IN denotes from
T5612 17346-17356 VB denotes stimulated
T5613 17357-17359 CC denotes or
T5614 17360-17372 JJ denotes unstimulated
T5615 17373-17378 NN denotes cells
T5616 17379-17383 VB denotes were
T5617 17384-17389 VB denotes added
T5618 17390-17392 TO denotes to
T5619 17393-17396 DT denotes the
T5620 17397-17414 JJ denotes importin-α-coated
T5621 17415-17420 NN denotes wells
T5622 17422-17424 NN denotes GR
T5623 17425-17426 -LRB- denotes (
T5624 17426-17428 CD denotes 10
T5625 17429-17431 CC denotes or
T5626 17432-17435 CD denotes 100
T5627 17436-17441 NN denotes ng/ml
T5628 17442-17444 IN denotes in
T5629 17445-17448 NN denotes TBS
T5630 17448-17449 -RRB- denotes )
T5631 17450-17454 IN denotes from
T5632 17455-17465 VB denotes stimulated
T5633 17466-17468 CC denotes or
T5634 17469-17481 JJ denotes unstimulated
T5635 17482-17487 NN denotes cells
T5636 17488-17492 VB denotes were
T5637 17493-17498 VB denotes added
T5638 17499-17501 TO denotes to
T5639 17502-17506 DT denotes some
T5640 17507-17512 NN denotes wells
T5641 17514-17519 IN denotes After
T5642 17520-17521 DT denotes a
T5643 17522-17529 JJ denotes further
T5644 17530-17531 CD denotes 1
T5645 17532-17533 NN denotes h
T5646 17534-17544 NN denotes incubation
T5647 17544-17545 -COMMA- denotes ,
T5648 17546-17549 DT denotes the
T5649 17550-17555 NN denotes plate
T5650 17556-17559 VB denotes was
T5651 17560-17566 VB denotes washed
T5652 17567-17570 CC denotes and
T5653 17571-17580 VB denotes incubated
T5654 17581-17585 IN denotes with
T5655 17586-17593 JJ denotes primary
T5656 17594-17604 NN denotes antibodies
T5657 17605-17606 -LRB- denotes (
T5658 17606-17607 DT denotes a
T5659 17608-17615 NN denotes mixture
T5660 17616-17618 IN denotes of
T5661 17619-17625 NN denotes rabbit
T5662 17626-17637 NN denotes anti-GATA-3
T5663 17638-17641 CC denotes and
T5664 17642-17647 NN denotes mouse
T5665 17648-17655 NN denotes anti-GR
T5666 17655-17656 -COMMA- denotes ,
T5667 17657-17662 NNP denotes Santa
T5668 17663-17667 NNP denotes Cruz
T5669 17668-17681 NNP denotes Biotechnology
T5670 17681-17682 -RRB- denotes )
T5671 17683-17686 IN denotes for
T5672 17687-17690 CD denotes 1.5
T5673 17691-17692 NN denotes h
T5674 17692-17693 -COMMA- denotes ,
T5675 17694-17697 CC denotes and
T5676 17698-17702 RB denotes then
T5677 17703-17712 VB denotes incubated
T5678 17713-17717 IN denotes with
T5679 17718-17727 JJ denotes secondary
T5680 17728-17738 NN denotes antibodies
T5681 17740-17744 NN denotes FITC
T5682 17745-17750 NN denotes swine
T5683 17751-17762 JJ denotes anti-rabbit
T5684 17763-17766 NN denotes IgG
T5685 17767-17768 -LRB- denotes (
T5686 17768-17772 NNP denotes Dako
T5687 17772-17773 -COMMA- denotes ,
T5688 17774-17783 NNP denotes Cambridge
T5689 17783-17784 -COMMA- denotes ,
T5690 17785-17787 NNP denotes UK
T5691 17787-17788 -RRB- denotes )
T5692 17789-17792 VB denotes was
T5693 17793-17797 VB denotes used
T5694 17798-17801 IN denotes for
T5695 17802-17805 DT denotes the
T5696 17806-17815 NN denotes detection
T5697 17816-17818 IN denotes of
T5698 17819-17825 NN denotes GATA-3
T5699 17825-17826 -COMMA- denotes ,
T5700 17827-17830 CC denotes and
T5701 17831-17840 NN denotes rhodamine
T5702 17841-17847 NN denotes donkey
T5703 17848-17858 JJ denotes anti-mouse
T5704 17859-17862 NN denotes IgG
T5705 17863-17864 -LRB- denotes (
T5706 17864-17869 NNP denotes Novus
T5707 17869-17870 -COMMA- denotes ,
T5708 17871-17880 NNP denotes Littleton
T5709 17880-17881 -COMMA- denotes ,
T5710 17882-17890 NNP denotes Colorado
T5711 17890-17891 -COMMA- denotes ,
T5712 17892-17895 NNP denotes USA
T5713 17895-17896 -RRB- denotes )
T5714 17897-17900 VB denotes was
T5715 17901-17905 VB denotes used
T5716 17906-17909 IN denotes for
T5717 17910-17913 DT denotes the
T5718 17914-17923 NN denotes detection
T5719 17924-17926 IN denotes of
T5720 17927-17929 NN denotes GR
T5721 17931-17935 NN denotes FITC
T5722 17936-17939 CC denotes and
T5723 17940-17949 NN denotes rhodamine
T5724 17950-17956 NN denotes levels
T5725 17957-17961 VB denotes were
T5726 17962-17970 VB denotes measured
T5727 17971-17975 IN denotes with
T5728 17976-17977 DT denotes a
T5729 17978-17989 JJ denotes fluorescent
T5730 17990-18001 NN denotes micro-plate
T5731 18002-18008 NN denotes reader
T5732 18009-18010 -LRB- denotes (
T5733 18010-18017 NNP denotes Bioline
T5734 18017-18018 -COMMA- denotes ,
T5735 18019-18025 NNP denotes London
T5736 18025-18026 -COMMA- denotes ,
T5737 18027-18029 NNP denotes UK
T5738 18029-18030 -RRB- denotes )
T6080 18033-18038 NN denotes NF-κB
T6081 18039-18049 NN denotes Activation
T6082 18050-18055 NN denotes NF-κB
T6083 18056-18063 NN denotes binding
T6084 18064-18072 NN denotes activity
T6085 18073-18075 IN denotes in
T6086 18076-18083 JJ denotes nuclear
T6087 18084-18092 NN denotes extracts
T6088 18093-18096 VB denotes was
T6089 18097-18107 VB denotes determined
T6090 18108-18113 VB denotes using
T6091 18114-18116 DT denotes an
T6092 18117-18128 JJ denotes ELISA-based
T6093 18129-18132 NN denotes kit
T6094 18133-18134 -LRB- denotes (
T6095 18134-18142 NN denotes Trans-AM
T6096 18143-18146 NN denotes p65
T6097 18146-18147 -COMMA- denotes ,
T6098 18148-18154 NNP denotes Active
T6099 18155-18160 NNP denotes Motif
T6100 18160-18161 -COMMA- denotes ,
T6101 18162-18171 NNP denotes Rixensart
T6102 18171-18172 -COMMA- denotes ,
T6103 18173-18180 NNP denotes Belgium
T6104 18180-18181 -RRB- denotes )
T6105 18183-18185 IN denotes In
T6106 18186-18191 NN denotes brief
T6107 18191-18192 -COMMA- denotes ,
T6108 18193-18194 CD denotes 5
T6109 18195-18197 NN denotes µg
T6110 18198-18200 IN denotes of
T6111 18201-18208 JJ denotes nuclear
T6112 18209-18217 NN denotes extracts
T6113 18218-18222 VB denotes were
T6114 18223-18232 VB denotes incubated
T6115 18233-18237 IN denotes with
T6116 18238-18239 DT denotes a
T6117 18240-18245 NN denotes plate
T6118 18246-18252 VB denotes coated
T6119 18253-18257 IN denotes with
T6120 18258-18260 DT denotes an
T6121 18261-18266 NN denotes NF-κB
T6122 18267-18276 NN denotes consensus
T6123 18277-18292 NN denotes oligonucleotide
T6124 18294-18300 NN denotes Plates
T6125 18301-18305 VB denotes were
T6126 18306-18312 VB denotes washed
T6127 18313-18319 IN denotes before
T6128 18320-18328 NN denotes addition
T6129 18329-18331 IN denotes of
T6130 18332-18334 DT denotes an
T6131 18335-18343 JJ denotes anti-p65
T6132 18344-18352 NN denotes antibody
T6133 18354-18362 NN denotes Antibody
T6134 18363-18370 NN denotes binding
T6135 18371-18374 VB denotes was
T6136 18375-18383 VB denotes detected
T6137 18384-18388 IN denotes with
T6138 18389-18390 DT denotes a
T6139 18391-18400 JJ denotes secondary
T6140 18401-18415 JJ denotes HRP-conjugated
T6141 18416-18424 NN denotes antibody
T6142 18425-18428 CC denotes and
T6143 18429-18438 VB denotes developed
T6144 18439-18443 IN denotes with
T6145 18444-18447 NN denotes TMB
T6146 18448-18457 NN denotes substrate
T6147 18459-18462 DT denotes The
T6148 18463-18472 NN denotes intensity
T6149 18473-18475 IN denotes of
T6150 18476-18479 DT denotes the
T6151 18480-18488 NN denotes reaction
T6152 18489-18492 VB denotes was
T6153 18493-18501 VB denotes measured
T6154 18502-18504 IN denotes at
T6155 18505-18508 CD denotes 450
T6156 18509-18511 NN denotes nm
T6283 18514-18532 NN denotes Immunofluorescence
T6284 18533-18541 NN denotes Staining
T6285 18542-18560 NN denotes Immunofluorescence
T6286 18561-18569 NN denotes staining
T6287 18570-18573 VB denotes was
T6288 18574-18583 VB denotes performed
T6289 18584-18586 IN denotes as
T6290 18587-18597 RB denotes previously
T6291 18598-18607 VB denotes described
T6292 18608-18609 -LRB- denotes [
T6293 18609-18611 CD denotes 34
T6294 18611-18612 -RRB- denotes ]
T6295 18614-18617 DT denotes All
T6296 18618-18626 NN denotes staining
T6297 18627-18630 VB denotes was
T6298 18631-18640 VB denotes performed
T6299 18641-18643 IN denotes at
T6300 18644-18648 NN denotes room
T6301 18649-18660 NN denotes temperature
T6302 18661-18664 CC denotes and
T6303 18665-18670 IN denotes under
T6304 18671-18685 NN denotes humidification
T6305 18687-18692 NN denotes Cells
T6306 18693-18697 VB denotes were
T6307 18698-18707 VB denotes collected
T6308 18708-18711 CC denotes and
T6309 18712-18721 NN denotes cytospins
T6310 18722-18730 VB denotes prepared
T6311 18731-18733 IN denotes in
T6312 18734-18735 DT denotes a
T6313 18736-18750 NN denotes cytocentrifuge
T6314 18751-18752 -LRB- denotes (
T6315 18752-18759 NNP denotes Shandon
T6316 18760-18762 NNP denotes II
T6317 18762-18763 -COMMA- denotes ,
T6318 18764-18771 NNP denotes Shandon
T6319 18771-18772 -COMMA- denotes ,
T6320 18773-18780 NNP denotes Runcorn
T6321 18780-18781 -COMMA- denotes ,
T6322 18782-18784 NNP denotes UK
T6323 18784-18785 -RRB- denotes )
T6324 18787-18792 NN denotes Cells
T6325 18793-18797 VB denotes were
T6326 18798-18811 VB denotes permeabilized
T6327 18811-18812 -COMMA- denotes ,
T6328 18813-18820 VB denotes blocked
T6329 18820-18821 -COMMA- denotes ,
T6330 18822-18825 CC denotes and
T6331 18826-18830 RB denotes then
T6332 18831-18840 VB denotes incubated
T6333 18841-18845 IN denotes with
T6334 18846-18848 NN denotes GR
T6335 18849-18850 -LRB- denotes (
T6336 18850-18854 CD denotes 1∶50
T6337 18855-18859 NN denotes E-20
T6338 18860-18865 NNP denotes Santa
T6339 18866-18870 NNP denotes Cruz
T6340 18871-18884 NNP denotes Biotechnology
T6341 18884-18885 -RRB- denotes )
T6342 18886-18888 CC denotes or
T6343 18889-18900 NN denotes anti-GATA-3
T6344 18901-18902 -LRB- denotes (
T6345 18902-18906 NN denotes H-48
T6346 18906-18907 -COLON- denotes ;
T6347 18908-18913 NNP denotes Santa
T6348 18914-18918 NNP denotes Cruz
T6349 18919-18932 NNP denotes Biotechnology
T6350 18932-18933 -RRB- denotes )
T6351 18934-18942 NN denotes antibody
T6352 18943-18946 IN denotes for
T6353 18947-18948 CD denotes 1
T6354 18949-18950 NN denotes h
T6355 18951-18953 IN denotes at
T6356 18954-18958 NN denotes room
T6357 18959-18970 NN denotes temperature
T6358 18972-18977 IN denotes After
T6359 18978-18983 CD denotes three
T6360 18984-18990 NN denotes washes
T6361 18991-18993 IN denotes in
T6362 18994-19012 JJ denotes phosphate-buffered
T6363 19013-19019 NN denotes saline
T6364 19020-19021 -LRB- denotes (
T6365 19021-19024 NN denotes PBS
T6366 19024-19025 -RRB- denotes )
T6367 19025-19026 -COMMA- denotes ,
T6368 19027-19032 NN denotes cells
T6369 19033-19037 VB denotes were
T6370 19038-19047 VB denotes incubated
T6371 19048-19052 IN denotes with
T6372 19053-19067 NN denotes tetrarhodamine
T6373 19068-19093 VB denotes isothiocyanate–conjugated
T6374 19094-19098 NN denotes goat
T6375 19099-19110 JJ denotes anti-rabbit
T6376 19111-19119 NN denotes antibody
T6377 19120-19121 -LRB- denotes (
T6378 19121-19125 NN denotes Dako
T6379 19125-19126 -RRB- denotes )
T6380 19128-19137 NN denotes Cytospins
T6381 19138-19142 VB denotes were
T6382 19143-19157 VB denotes counterstained
T6383 19158-19162 IN denotes with
T6384 19163-19165 NN denotes 4′
T6385 19165-19166 -COMMA- denotes ,
T6386 19166-19192 NN denotes 6-diamidino-2-phenylindole
T6387 19193-19208 NN denotes dihydrochloride
T6388 19209-19210 -LRB- denotes (
T6389 19210-19214 NN denotes DAPI
T6390 19214-19215 -RRB- denotes )
T6391 19215-19216 -COMMA- denotes ,
T6392 19217-19218 DT denotes a
T6393 19219-19230 JJ denotes fluorescent
T6394 19231-19235 JJ denotes blue
T6395 19236-19243 JJ denotes nuclear
T6396 19244-19250 NN denotes indole
T6397 19251-19260 NN denotes chromatin
T6398 19261-19266 NN denotes stain
T6399 19266-19267 -COMMA- denotes ,
T6400 19268-19271 CC denotes and
T6401 19272-19279 VB denotes mounted
T6402 19280-19282 IN denotes in
T6403 19283-19286 NNP denotes PBS
T6404 19286-19287 -COLON- denotes :
T6405 19287-19295 NN denotes glycerol
T6406 19296-19297 -LRB- denotes (
T6407 19297-19302 CD denotes 50∶50
T6408 19302-19303 -RRB- denotes )
T6409 19305-19308 DT denotes The
T6410 19309-19323 JJ denotes immunopositive
T6411 19324-19330 NN denotes signal
T6412 19331-19334 VB denotes was
T6413 19335-19348 VB denotes characterised
T6414 19349-19354 VB denotes using
T6415 19355-19360 NN denotes laser
T6416 19361-19369 NN denotes scanning
T6417 19370-19378 JJ denotes confocal
T6418 19379-19389 NN denotes microscopy
T6419 19390-19392 IN denotes on
T6420 19393-19394 DT denotes a
T6421 19395-19400 NNP denotes Leica
T6422 19401-19404 NNP denotes TCS
T6423 19405-19410 NNP denotes NT/SP
T6424 19411-19422 JJ denotes interactive
T6425 19423-19428 NN denotes laser
T6426 19429-19438 NN denotes cytometer
T6427 19439-19447 VB denotes equipped
T6428 19448-19452 IN denotes with
T6429 19453-19461 JJ denotes confocal
T6430 19462-19468 NN denotes optics
T6431 19469-19470 -LRB- denotes (
T6432 19470-19475 NNP denotes Leica
T6433 19476-19488 NNP denotes Microsystems
T6434 19488-19489 -COMMA- denotes ,
T6435 19490-19497 NNP denotes Wetzlar
T6436 19497-19498 -COMMA- denotes ,
T6437 19499-19506 NNP denotes Germany
T6438 19506-19507 -RRB- denotes )
T6439 19509-19511 TO denotes To
T6440 19512-19521 VB denotes determine
T6441 19522-19525 DT denotes the
T6442 19526-19537 NN denotes specificity
T6443 19538-19540 IN denotes of
T6444 19541-19544 DT denotes the
T6445 19545-19555 NN denotes antibodies
T6446 19555-19556 -COMMA- denotes ,
T6447 19557-19563 NN denotes rabbit
T6448 19564-19569 NN denotes serum
T6449 19570-19584 NN denotes immunoglobulin
T6450 19585-19586 -LRB- denotes (
T6451 19586-19590 NN denotes Dako
T6452 19590-19591 -RRB- denotes )
T6453 19592-19595 CC denotes and
T6454 19596-19605 JJ denotes secondary
T6455 19606-19616 NN denotes antibodies
T6456 19617-19624 IN denotes without
T6457 19625-19628 DT denotes the
T6458 19629-19636 JJ denotes primary
T6459 19637-19641 VB denotes were
T6460 19642-19646 VB denotes used
T6461 19647-19649 IN denotes as
T6462 19650-19658 NN denotes controls
T6463 19660-19670 RB denotes Positively
T6464 19671-19678 VB denotes stained
T6465 19679-19685 NN denotes nuclei
T6466 19686-19689 CC denotes and
T6467 19690-19695 JJ denotes total
T6468 19696-19701 NN denotes cells
T6469 19702-19706 VB denotes were
T6470 19707-19714 VB denotes counted
T6471 19715-19716 -LRB- denotes (
T6472 19716-19719 CD denotes 500
T6473 19719-19720 -RRB- denotes )
T6474 19721-19723 IN denotes on
T6475 19724-19728 DT denotes each
T6476 19729-19734 NN denotes slide
T6477 19735-19739 IN denotes with
T6478 19740-19743 DT denotes the
T6479 19744-19752 NN denotes observer
T6480 19753-19760 VB denotes blinded
T6481 19761-19763 TO denotes to
T6482 19764-19767 DT denotes the
T6483 19768-19777 NN denotes treatment
T6779 19780-19790 NN denotes GATA-3-GFP
T6780 19791-19800 NN denotes Construct
T6781 19801-19804 DT denotes The
T6782 19805-19811 NN denotes GATA-3
T6783 19812-19817 NN denotes clone
T6784 19818-19819 -LRB- denotes (
T6785 19819-19827 NN denotes BC003070
T6786 19827-19828 -RRB- denotes )
T6787 19829-19837 JJ denotes complete
T6788 19838-19842 NN denotes cDNA
T6789 19843-19846 VB denotes was
T6790 19847-19855 VB denotes obtained
T6791 19856-19860 IN denotes from
T6792 19861-19871 NNP denotes Invitrogen
T6793 19872-19876 NNP denotes Life
T6794 19877-19889 NNP denotes Technologies
T6795 19890-19892 IN denotes as
T6796 19893-19894 DT denotes a
T6797 19895-19898 JJ denotes 5′-
T6798 19899-19912 NN denotes EcoRI/3′-XhoI
T6799 19913-19919 NN denotes insert
T6800 19920-19922 IN denotes of
T6801 19923-19929 NN denotes GATA-3
T6802 19930-19932 IN denotes in
T6803 19933-19936 DT denotes the
T6804 19937-19942 NN denotes pOTB7
T6805 19943-19949 NN denotes vector
T6806 19951-19957 NN denotes GATA-3
T6807 19958-19961 VB denotes was
T6808 19962-19969 VB denotes excised
T6809 19970-19974 IN denotes from
T6810 19975-19980 NN denotes pOTB7
T6811 19981-19986 VB denotes using
T6812 19987-19991 NN denotes XhoI
T6813 19992-20001 NN denotes digestion
T6814 20002-20005 CC denotes and
T6815 20006-20014 NN denotes pEGFP-C2
T6816 20015-20016 -LRB- denotes (
T6817 20016-20024 NNP denotes Clontech
T6818 20024-20025 -COMMA- denotes ,
T6819 20026-20047 NNP denotes Saint-Germain-en-Laye
T6820 20047-20048 -COMMA- denotes ,
T6821 20049-20055 NNP denotes France
T6822 20055-20056 -RRB- denotes )
T6823 20057-20060 VB denotes was
T6824 20061-20069 VB denotes digested
T6825 20070-20074 IN denotes with
T6826 20075-20080 NN denotes BamHI
T6827 20082-20085 NN denotes DNA
T6828 20086-20089 VB denotes was
T6829 20090-20099 VB denotes recovered
T6830 20100-20102 IN denotes by
T6831 20103-20109 NN denotes phenol
T6832 20110-20120 NN denotes extraction
T6833 20121-20124 CC denotes and
T6834 20125-20132 NN denotes ethanol
T6835 20133-20146 NN denotes precipitation
T6836 20146-20147 -COMMA- denotes ,
T6837 20148-20151 CC denotes and
T6838 20152-20156 CC denotes both
T6839 20157-20160 DT denotes the
T6840 20161-20167 NN denotes GATA-3
T6841 20168-20176 NN denotes fragment
T6842 20177-20180 CC denotes and
T6843 20181-20184 DT denotes the
T6844 20185-20193 NN denotes pEGFP-C2
T6845 20194-20200 NN denotes vector
T6846 20201-20212 JJ denotes blunt-ended
T6847 20213-20215 IN denotes by
T6848 20216-20226 NN denotes incubation
T6849 20227-20231 IN denotes with
T6850 20232-20238 NNP denotes Klenow
T6851 20239-20240 -LRB- denotes (
T6852 20240-20247 NN denotes Bioline
T6853 20248-20257 NN denotes Bio-27029
T6854 20257-20258 -RRB- denotes )
T6855 20259-20262 IN denotes for
T6856 20263-20265 CD denotes 30
T6857 20266-20269 NN denotes min
T6858 20270-20272 IN denotes at
T6859 20273-20278 NNP denotes 37°C.
T6860 20279-20285 NNP denotes Klenow
T6861 20286-20289 VB denotes was
T6862 20290-20301 VB denotes inactivated
T6863 20302-20304 IN denotes by
T6864 20305-20315 NN denotes incubation
T6865 20316-20319 IN denotes for
T6866 20320-20322 CD denotes 10
T6867 20323-20326 NN denotes min
T6868 20327-20329 IN denotes at
T6869 20330-20335 NNP denotes 75°C.
T6870 20336-20339 NN denotes DNA
T6871 20340-20343 VB denotes was
T6872 20344-20353 VB denotes recovered
T6873 20354-20356 IN denotes by
T6874 20357-20363 NN denotes phenol
T6875 20364-20374 NN denotes extraction
T6876 20375-20378 CC denotes and
T6877 20379-20386 NN denotes ethanol
T6878 20387-20400 NN denotes precipitation
T6879 20400-20401 -COMMA- denotes ,
T6880 20402-20405 CC denotes and
T6881 20406-20410 CC denotes both
T6882 20411-20414 DT denotes the
T6883 20415-20426 JJ denotes blunt-ended
T6884 20427-20433 NN denotes GATA-3
T6885 20434-20442 NN denotes fragment
T6886 20443-20446 CC denotes and
T6887 20447-20450 DT denotes the
T6888 20451-20454 NN denotes GFP
T6889 20455-20461 NN denotes vector
T6890 20462-20466 VB denotes were
T6891 20467-20479 RB denotes subsequently
T6892 20480-20488 VB denotes digested
T6893 20489-20493 IN denotes with
T6894 20494-20499 NN denotes EcoRI
T6895 20500-20506 IN denotes before
T6896 20507-20510 DT denotes the
T6897 20511-20528 JJ denotes 5′-EcoRI/3′–blunt
T6898 20529-20532 NN denotes end
T6899 20533-20539 NN denotes GATA-3
T6900 20540-20548 NN denotes fragment
T6901 20549-20552 VB denotes was
T6902 20553-20561 VB denotes inserted
T6903 20562-20566 IN denotes into
T6904 20567-20570 DT denotes the
T6905 20571-20588 NN denotes 5′-EcoRI/3′–blunt
T6906 20589-20594 VB denotes ended
T6907 20595-20598 NN denotes GFP
T6908 20599-20605 NN denotes vector
T6909 20607-20615 JJ denotes Positive
T6910 20616-20622 NN denotes clones
T6911 20623-20627 VB denotes were
T6912 20628-20637 VB denotes confirmed
T6913 20638-20640 IN denotes by
T6914 20641-20650 NN denotes digestion
T6915 20651-20654 CC denotes and
T6916 20655-20659 NN denotes size
T6917 20660-20668 NN denotes analysis
T6918 20669-20671 IN denotes by
T6919 20672-20673 CD denotes 1
T6920 20673-20674 NN denotes %
T6921 20675-20682 NN denotes agarose
T6922 20683-20686 NN denotes gel
T6923 20687-20702 NN denotes electrophoresis
T6924 20703-20706 CC denotes and
T6925 20707-20709 IN denotes by
T6926 20710-20720 NN denotes sequencing
T7172 20723-20735 NN denotes Transfection
T7173 20736-20742 NN denotes HuT-78
T7174 20743-20748 NN denotes cells
T7175 20749-20753 VB denotes were
T7176 20754-20765 VB denotes transfected
T7177 20766-20770 IN denotes with
T7178 20771-20777 CC denotes either
T7179 20778-20781 NN denotes EP8
T7180 20782-20784 CC denotes or
T7181 20785-20788 NN denotes GFP
T7182 20789-20795 NN denotes vector
T7183 20796-20800 RB denotes only
T7184 20801-20804 NN denotes DNA
T7185 20805-20810 VB denotes using
T7186 20811-20819 NN denotes solution
T7187 20820-20821 NNP denotes R
T7188 20821-20822 -COMMA- denotes ,
T7189 20823-20832 NN denotes programme
T7190 20833-20838 NN denotes V-001
T7191 20839-20841 IN denotes at
T7192 20842-20843 DT denotes a
T7193 20844-20849 NN denotes ratio
T7194 20850-20852 IN denotes of
T7195 20853-20858 CD denotes 3×106
T7196 20859-20866 NN denotes cells/4
T7197 20867-20869 VB denotes µg
T7198 20870-20873 NN denotes DNA
T7199 20874-20877 IN denotes for
T7200 20878-20881 CD denotes 7–8
T7201 20882-20883 NN denotes h
T7202 20884-20886 IN denotes in
T7203 20887-20895 JJ denotes complete
T7204 20896-20902 NN denotes medium
T7205 20903-20904 -LRB- denotes (
T7206 20904-20906 CD denotes 10
T7207 20906-20907 NN denotes %
T7208 20908-20914 JJ denotes bovine
T7209 20915-20920 NN denotes serum
T7210 20921-20923 IN denotes in
T7211 20924-20935 NN denotes RPMI1640+15
T7212 20936-20947 NN denotes L-glutamine
T7213 20947-20948 -RRB- denotes )
T7214 20949-20958 VB denotes according
T7215 20959-20961 TO denotes to
T7216 20962-20965 DT denotes the
T7217 20966-20973 JJ denotes general
T7218 20974-20979 NNP denotes Amaxa
T7219 20980-20988 NN denotes protocol
T7220 20989-20992 IN denotes for
T7221 20993-21006 NN denotes nucleofection
T7222 21008-21011 DT denotes The
T7223 21012-21018 NN denotes medium
T7224 21019-21022 VB denotes was
T7225 21023-21035 RB denotes subsequently
T7226 21036-21043 VB denotes changed
T7227 21044-21046 TO denotes to
T7228 21047-21048 CD denotes 1
T7229 21048-21049 NN denotes %
T7230 21050-21054 NN denotes RPMI
T7231 21055-21058 IN denotes for
T7232 21059-21061 CD denotes 24
T7233 21062-21063 NN denotes h
T7234 21064-21070 IN denotes before
T7235 21071-21082 VB denotes transfected
T7236 21083-21088 NN denotes cells
T7237 21089-21093 VB denotes were
T7238 21094-21099 VB denotes added
T7239 21100-21102 TO denotes to
T7240 21103-21116 JJ denotes anti-CD3/CD28
T7241 21117-21124 VB denotes treated
T7242 21125-21130 NN denotes wells
T7243 21131-21134 CC denotes and
T7244 21135-21139 JJ denotes live
T7245 21140-21144 NN denotes cell
T7246 21145-21160 NN denotes videomicroscopy
T7247 21161-21170 VB denotes performed
T7357 21173-21183 NNP denotes Time-Lapse
T7358 21184-21194 NNP denotes Microscopy
T7359 21195-21201 NN denotes HuT-78
T7360 21202-21207 NN denotes cells
T7361 21208-21218 VB denotes expressing
T7362 21219-21229 NN denotes GATA-3-GFP
T7363 21230-21234 VB denotes were
T7364 21235-21245 VB denotes maintained
T7365 21246-21248 IN denotes at
T7366 21249-21253 NN denotes 37°C
T7367 21254-21256 IN denotes in
T7368 21257-21263 NN denotes growth
T7369 21264-21270 NN denotes medium
T7370 21271-21273 IN denotes in
T7371 21274-21275 DT denotes a
T7372 21276-21282 JJ denotes closed
T7373 21283-21287 NN denotes FCS2
T7374 21288-21297 NN denotes perfusion
T7375 21298-21305 NN denotes chamber
T7376 21306-21307 -LRB- denotes (
T7377 21307-21316 NNP denotes Bioptechs
T7378 21316-21317 -COMMA- denotes ,
T7379 21318-21324 NNP denotes Butler
T7380 21324-21325 -COMMA- denotes ,
T7381 21326-21338 NNP denotes Pennsylvania
T7382 21338-21339 -COMMA- denotes ,
T7383 21340-21343 NNP denotes USA
T7384 21343-21344 -RRB- denotes )
T7385 21345-21353 VB denotes combined
T7386 21354-21358 IN denotes with
T7387 21359-21361 DT denotes an
T7388 21362-21371 JJ denotes objective
T7389 21372-21378 NN denotes heater
T7390 21379-21380 -LRB- denotes (
T7391 21380-21389 NN denotes Bioptechs
T7392 21389-21390 -RRB- denotes )
T7393 21391-21393 IN denotes on
T7394 21394-21397 DT denotes the
T7395 21398-21403 NN denotes stage
T7396 21404-21405 DT denotes a
T7397 21406-21411 NNP denotes Zeiss
T7398 21412-21420 NNP denotes Axiovert
T7399 21421-21424 CD denotes 200
T7400 21425-21435 NN denotes microscope
T7401 21436-21437 -LRB- denotes (
T7402 21437-21446 NNP denotes Thornwood
T7403 21446-21447 -COMMA- denotes ,
T7404 21448-21451 NNP denotes New
T7405 21452-21456 NNP denotes York
T7406 21456-21457 -COMMA- denotes ,
T7407 21458-21461 NNP denotes USA
T7408 21461-21462 -RRB- denotes )
T7409 21464-21476 NN denotes Observations
T7410 21477-21481 VB denotes were
T7411 21482-21486 VB denotes made
T7412 21487-21489 IN denotes by
T7413 21490-21496 CD denotes 40×1.0
T7414 21497-21499 NN denotes NA
T7415 21500-21513 NN denotes oil-immersion
T7416 21514-21523 JJ denotes objective
T7417 21524-21528 NN denotes lens
T7418 21528-21529 -COMMA- denotes ,
T7419 21530-21533 CC denotes and
T7420 21534-21546 NN denotes fluorescence
T7421 21547-21550 CC denotes and
T7422 21551-21556 NN denotes phase
T7423 21557-21565 NN denotes contrast
T7424 21566-21572 NN denotes images
T7425 21573-21577 VB denotes were
T7426 21578-21586 VB denotes gathered
T7427 21587-21592 VB denotes using
T7428 21593-21594 DT denotes a
T7429 21595-21604 NNP denotes Hamamatsu
T7430 21605-21612 NNP denotes ORCA-ER
T7431 21613-21620 VB denotes charged
T7432 21621-21628 VB denotes coupled
T7433 21629-21635 NN denotes device
T7434 21636-21642 NN denotes camera
T7435 21643-21644 -LRB- denotes (
T7436 21644-21655 NNP denotes Bridgewater
T7437 21655-21656 -COMMA- denotes ,
T7438 21657-21660 NNP denotes New
T7439 21661-21667 NNP denotes Jersey
T7440 21667-21668 -COMMA- denotes ,
T7441 21669-21672 NNP denotes USA
T7442 21672-21673 -RRB- denotes )
T7443 21674-21680 VB denotes driven
T7444 21681-21683 IN denotes by
T7445 21684-21691 NN denotes Openlab
T7446 21692-21700 NN denotes software
T7447 21701-21702 -LRB- denotes (
T7448 21702-21713 NNP denotes Improvision
T7449 21713-21714 -COMMA- denotes ,
T7450 21715-21723 NNP denotes Coventry
T7451 21723-21724 -COMMA- denotes ,
T7452 21725-21727 NNP denotes UK
T7453 21727-21728 -RRB- denotes )
T7454 21730-21741 NN denotes Photographs
T7455 21742-21746 VB denotes were
T7456 21747-21752 VB denotes taken
T7457 21753-21755 IN denotes at
T7458 21756-21757 CD denotes 0
T7459 21757-21758 -COMMA- denotes ,
T7460 21759-21761 CD denotes 30
T7461 21761-21762 -COMMA- denotes ,
T7462 21763-21765 CD denotes 60
T7463 21765-21766 -COMMA- denotes ,
T7464 21767-21770 CD denotes 120
T7465 21770-21771 -COMMA- denotes ,
T7466 21772-21775 CC denotes and
T7467 21776-21779 CD denotes 240
T7468 21780-21783 NN denotes min
T7611 21786-21799 JJ denotes Densitometric
T7612 21800-21808 NN denotes Analysis
T7613 21809-21821 NN denotes Densitometry
T7614 21822-21824 IN denotes of
T7615 21825-21828 NN denotes ECL
T7616 21829-21840 NN denotes immunoblots
T7617 21841-21844 VB denotes was
T7618 21845-21854 VB denotes performed
T7619 21855-21860 VB denotes using
T7620 21861-21869 NNP denotes Gelworks
T7621 21870-21872 NNP denotes ID
T7622 21873-21885 JJ denotes intermediate
T7623 21886-21894 NN denotes software
T7624 21895-21896 -LRB- denotes (
T7625 21896-21907 NNP denotes Ultraviolet
T7626 21908-21916 NNP denotes Products
T7627 21916-21917 -COMMA- denotes ,
T7628 21918-21932 NNP denotes Cambridgeshire
T7629 21932-21933 -COMMA- denotes ,
T7630 21934-21936 NNP denotes UK
T7631 21936-21937 -RRB- denotes )
T7632 21939-21946 RB denotes Briefly
T7633 21946-21947 -COMMA- denotes ,
T7634 21948-21959 NN denotes immunoblots
T7635 21960-21964 VB denotes were
T7636 21965-21972 VB denotes scanned
T7637 21973-21976 CC denotes and
T7638 21977-21982 NN denotes gates
T7639 21983-21987 VB denotes were
T7640 21988-21993 VB denotes drawn
T7641 21994-22001 RB denotes tightly
T7642 22002-22008 IN denotes around
T7643 22009-22013 DT denotes each
T7644 22014-22018 NN denotes band
T7645 22020-22030 NN denotes Background
T7646 22031-22037 NN denotes values
T7647 22038-22042 IN denotes from
T7648 22043-22047 DT denotes each
T7649 22048-22052 NN denotes lane
T7650 22053-22057 VB denotes were
T7651 22058-22068 VB denotes subtracted
T7652 22069-22071 TO denotes to
T7653 22072-22081 VB denotes normalize
T7654 22082-22086 DT denotes each
T7655 22087-22098 NN denotes measurement
T7656 22100-22103 DT denotes The
T7657 22104-22109 NN denotes bands
T7658 22110-22114 VB denotes were
T7659 22115-22125 VB denotes quantified
T7660 22126-22131 VB denotes using
T7661 22132-22135 DT denotes the
T7662 22136-22144 NNP denotes Gelworks
T7663 22145-22153 NN denotes software
T7664 22155-22158 DT denotes All
T7665 22159-22166 JJ denotes Western
T7666 22167-22172 NN denotes blots
T7667 22173-22177 VB denotes were
T7668 22178-22185 VB denotes exposed
T7669 22186-22188 TO denotes to
T7670 22189-22193 VB denotes film
T7671 22194-22197 IN denotes for
T7672 22198-22205 VB denotes varying
T7673 22206-22213 NN denotes lengths
T7674 22214-22216 IN denotes of
T7675 22217-22221 NN denotes time
T7676 22221-22222 -COMMA- denotes ,
T7677 22223-22226 CC denotes and
T7678 22227-22231 RB denotes only
T7679 22232-22237 NN denotes films
T7680 22238-22248 VB denotes generating
T7681 22249-22262 JJ denotes subsaturating
T7682 22263-22269 NN denotes levels
T7683 22270-22272 IN denotes of
T7684 22273-22282 NN denotes intensity
T7685 22283-22287 VB denotes were
T7686 22288-22296 VB denotes selected
T7687 22297-22300 IN denotes for
T7688 22301-22314 JJ denotes densitometric
T7689 22315-22325 NN denotes evaluation
T7787 22328-22339 JJ denotes Statistical
T7788 22340-22348 NN denotes Analysis
T7789 22349-22353 NN denotes Data
T7790 22354-22358 IN denotes from
T7791 22359-22364 CD denotes three
T7792 22365-22367 CC denotes or
T7793 22368-22372 JJ denotes more
T7794 22373-22384 JJ denotes independent
T7795 22385-22396 NN denotes experiments
T7796 22397-22400 VB denotes are
T7797 22401-22410 VB denotes presented
T7798 22411-22413 IN denotes as
T7799 22414-22417 DT denotes the
T7800 22418-22431 NN denotes mean±standard
T7801 22432-22437 NN denotes error
T7802 22438-22440 IN denotes of
T7803 22441-22444 DT denotes the
T7804 22445-22449 JJ denotes mean
T7805 22450-22451 -LRB- denotes (
T7806 22451-22454 NN denotes SEM
T7807 22454-22455 -RRB- denotes )
T7808 22455-22456 -COMMA- denotes ,
T7809 22457-22463 IN denotes except
T7810 22464-22469 WRB denotes where
T7811 22470-22476 VB denotes stated
T7812 22477-22480 CC denotes and
T7813 22481-22485 VB denotes were
T7814 22486-22494 VB denotes compared
T7815 22495-22500 VB denotes using
T7816 22501-22509 NNP denotes GraphPad
T7817 22510-22515 NNP denotes Prism
T7818 22516-22517 CD denotes 4
T7819 22518-22519 -LRB- denotes (
T7820 22519-22527 NNP denotes GraphPad
T7821 22528-22536 NNP denotes Software
T7822 22536-22537 -COMMA- denotes ,
T7823 22538-22542 NN denotes http
T7824 22542-22543 -COLON- denotes :
T7825 22543-22561 LS denotes //www.graphpad.com
T7826 22561-22562 -RRB- denotes )
T7827 22564-22571 NN denotes Results
T7828 22572-22576 VB denotes were
T7829 22577-22585 VB denotes analysed
T7830 22586-22591 VB denotes using
T7831 22592-22599 JJ denotes one-way
T7832 22600-22605 NN denotes ANOVA
T7833 22606-22610 IN denotes with
T7834 22611-22623 NN denotes Newman-Keuls
T7835 22624-22628 NN denotes post
T7836 22629-22633 NN denotes test
T7837 22634-22640 IN denotes except
T7838 22641-22644 IN denotes for
T7839 22645-22648 DT denotes the
T7840 22649-22653 NN denotes data
T7841 22654-22658 IN denotes from
T7842 22659-22662 DT denotes the
T7843 22663-22665 FW denotes in
T7844 22666-22670 FW denotes vivo
T7845 22671-22678 VB denotes inhaled
T7846 22679-22681 NN denotes FP
T7847 22682-22687 NN denotes study
T7848 22687-22688 -COMMA- denotes ,
T7849 22689-22694 WDT denotes which
T7850 22695-22698 VB denotes was
T7851 22699-22707 VB denotes analysed
T7852 22708-22710 IN denotes by
T7853 22711-22719 NNP denotes Friedman
T7854 22719-22721 POS denotes 's
T7855 22722-22726 NN denotes test
T7856 22727-22731 IN denotes with
T7857 22732-22742 JJ denotes subsequent
T7858 22743-22752 NNP denotes Wilcoxson
T7859 22753-22760 VB denotes matched
T7860 22761-22765 NN denotes pair
T7861 22766-22772 VB denotes signed
T7862 22773-22777 NN denotes rank
T7863 22778-22781 NN denotes sum
T7864 22782-22786 NN denotes test
T7865 22788-22792 NN denotes Data
T7866 22793-22797 IN denotes from
T7867 22798-22802 DT denotes this
T7868 22803-22811 NN denotes analysis
T7869 22812-22815 VB denotes are
T7870 22816-22825 VB denotes presented
T7871 22826-22828 IN denotes as
T7872 22829-22830 DT denotes a
T7873 22831-22847 NN denotes box-and-whiskers
T7874 22848-22852 NN denotes plot
T7875 22854-22862 NNP denotes Friedman
T7876 22862-22864 POS denotes 's
T7877 22865-22869 NN denotes test
T7878 22870-22873 VB denotes was
T7879 22874-22878 VB denotes used
T7880 22879-22881 IN denotes as
T7881 22882-22887 CD denotes three
T7882 22888-22895 JJ denotes matched
T7883 22896-22904 NN denotes measures
T7884 22905-22909 VB denotes were
T7885 22910-22918 VB denotes obtained
T7886 22919-22924 VB denotes using
T7887 22925-22932 NN denotes placebo
T7888 22932-22933 -COMMA- denotes ,
T7889 22934-22937 CD denotes 100
T7890 22938-22940 NN denotes µg
T7891 22940-22941 -COMMA- denotes ,
T7892 22942-22945 CC denotes and
T7893 22946-22949 CD denotes 500
T7894 22950-22952 NN denotes µg
T7895 22953-22955 IN denotes of
T7896 22956-22963 VB denotes inhaled
T7897 22964-22966 NN denotes FP
T7898 22966-22967 -COMMA- denotes ,
T7899 22968-22973 WDT denotes which
T7900 22974-22977 VB denotes had
T7901 22978-22986 JJ denotes variable
T7902 22987-22995 NN denotes baseline
T7903 22996-23002 NN denotes levels
T7904 23004-23006 PRP denotes We
T7905 23007-23010 VB denotes did
T7906 23011-23014 RB denotes not
T7907 23015-23021 VB denotes assume
T7908 23022-23023 DT denotes a
T7909 23024-23032 JJ denotes Gaussian
T7910 23033-23045 NN denotes distribution
T7911 23046-23048 IN denotes of
T7912 23049-23052 DT denotes the
T7913 23053-23057 NN denotes data
T7914 23058-23061 JJ denotes due
T7915 23062-23064 TO denotes to
T7916 23065-23068 DT denotes the
T7917 23069-23076 JJ denotes limited
T7918 23077-23084 NN denotes numbers
T7919 23085-23087 IN denotes of
T7920 23088-23100 NN denotes participants
T7921 23101-23109 VB denotes analysed
T7922 23110-23111 -LRB- denotes (
T7923 23111-23116 CD denotes seven
T7924 23116-23117 -RRB- denotes )
T7925 23117-23121 NN denotes .The
T7926 23122-23126 JJ denotes null
T7927 23127-23137 NN denotes hypothesis
T7928 23138-23141 VB denotes was
T7929 23142-23150 VB denotes rejected
T7930 23151-23153 IN denotes at
T7931 23154-23155 NN denotes p
T7932 23155-23156 SYM denotes <
T7933 23156-23160 CD denotes 0.05
T8245 23172-23175 DT denotes The
T8246 23176-23182 NN denotes Effect
T8247 23183-23185 IN denotes of
T8248 23186-23201 NN denotes Corticosteroids
T8249 23202-23204 IN denotes on
T8250 23205-23211 NN denotes GATA-3
T8251 23212-23219 JJ denotes Nuclear
T8252 23220-23233 NN denotes Translocation
T8253 23234-23237 CC denotes and
T8254 23238-23242 NN denotes IL-4
T8255 23243-23247 NN denotes mRNA
T8256 23248-23263 NN denotes Corticosteroids
T8257 23264-23267 VB denotes are
T8258 23268-23277 JJ denotes effective
T8259 23278-23280 IN denotes in
T8260 23281-23291 VB denotes inhibiting
T8261 23292-23308 JJ denotes GATA-3-regulated
T8262 23309-23313 NN denotes IL-4
T8263 23314-23318 NN denotes gene
T8264 23319-23329 NN denotes expression
T8265 23330-23332 FW denotes in
T8266 23333-23338 FW denotes vitro
T8267 23339-23342 CC denotes and
T8268 23343-23345 FW denotes in
T8269 23346-23350 FW denotes vivo
T8270 23351-23352 -LRB- denotes [
T8271 23352-23354 CD denotes 32
T8272 23354-23355 -RRB- denotes ]
T8273 23357-23359 PRP denotes We
T8274 23360-23369 RB denotes therefore
T8275 23370-23382 VB denotes investigated
T8276 23383-23390 IN denotes whether
T8277 23391-23406 NN denotes corticosteroids
T8278 23407-23413 VB denotes affect
T8279 23414-23438 JJ denotes anti-CD3/CD28–stimulated
T8280 23439-23446 JJ denotes nuclear
T8281 23447-23453 NN denotes import
T8282 23454-23456 IN denotes of
T8283 23457-23463 NN denotes GATA-3
T8284 23465-23476 NN denotes Stimulation
T8285 23477-23479 IN denotes of
T8286 23480-23485 NN denotes cells
T8287 23486-23490 IN denotes with
T8288 23491-23504 NN denotes anti-CD3/CD28
T8289 23505-23513 VB denotes resulted
T8290 23514-23516 IN denotes in
T8291 23517-23518 DT denotes a
T8292 23519-23524 JJ denotes rapid
T8293 23525-23544 JJ denotes cytoplasmic/nuclear
T8294 23545-23551 NN denotes GATA-3
T8295 23552-23565 NN denotes translocation
T8296 23566-23567 -LRB- denotes (
T8297 23567-23573 NN denotes Figure
T8298 23574-23576 NN denotes 1A
T8299 23576-23577 -RRB- denotes )
T8300 23577-23578 -COMMA- denotes ,
T8301 23579-23589 VB denotes confirming
T8302 23590-23593 PRP-DOLLAR- denotes our
T8303 23594-23602 JJ denotes previous
T8304 23603-23610 NN denotes results
T8305 23611-23612 -LRB- denotes [
T8306 23612-23614 CD denotes 12
T8307 23614-23615 -RRB- denotes ]
T8308 23617-23619 PRP denotes We
T8309 23620-23624 RB denotes also
T8310 23625-23634 VB denotes confirmed
T8311 23635-23636 DT denotes a
T8312 23637-23642 JJ denotes clear
T8313 23643-23653 NN denotes separation
T8314 23654-23656 IN denotes of
T8315 23657-23664 JJ denotes nuclear
T8316 23665-23668 CC denotes and
T8317 23669-23678 JJ denotes cytosolic
T8318 23679-23688 NN denotes fractions
T8319 23689-23691 IN denotes as
T8320 23692-23701 VB denotes indicated
T8321 23702-23704 IN denotes by
T8322 23705-23712 NN denotes histone
T8323 23713-23715 NN denotes H1
T8324 23716-23719 CC denotes and
T8325 23720-23725 NN denotes MEK-1
T8326 23726-23733 NN denotes markers
T8327 23734-23735 -LRB- denotes (
T8328 23735-23741 NN denotes Figure
T8329 23742-23744 NN denotes 1B
T8330 23744-23745 -RRB- denotes )
T8331 23747-23750 DT denotes The
T8332 23751-23757 JJ denotes potent
T8333 23758-23765 JJ denotes topical
T8334 23766-23780 NN denotes corticosteroid
T8335 23781-23783 NN denotes FP
T8336 23784-23790 VB denotes caused
T8337 23791-23800 JJ denotes sustained
T8338 23801-23805 NN denotes loss
T8339 23806-23808 IN denotes of
T8340 23809-23816 JJ denotes nuclear
T8341 23817-23823 NN denotes GATA-3
T8342 23824-23834 NN denotes expression
T8343 23835-23838 CC denotes and
T8344 23839-23850 JJ denotes cytoplasmic
T8345 23851-23860 NN denotes retention
T8346 23861-23863 IN denotes of
T8347 23864-23870 NN denotes GATA-3
T8348 23871-23873 IN denotes at
T8349 23874-23888 NN denotes concentrations
T8350 23889-23896 VB denotes ranging
T8351 23897-23901 IN denotes from
T8352 23902-23907 CD denotes 10−12
T8353 23908-23910 TO denotes to
T8354 23911-23915 CD denotes 10−8
T8355 23916-23917 NN denotes M
T8356 23917-23918 -COMMA- denotes ,
T8357 23919-23924 WDT denotes which
T8358 23925-23930 VB denotes cover
T8359 23931-23934 DT denotes the
T8360 23935-23946 JJ denotes therapeutic
T8361 23947-23952 NN denotes range
T8362 23953-23954 -LRB- denotes [
T8363 23954-23956 CD denotes 37
T8364 23956-23957 -RRB- denotes ]
T8365 23959-23963 DT denotes This
T8366 23964-23970 NN denotes effect
T8367 23971-23974 VB denotes was
T8368 23975-23989 NN denotes concentration-
T8369 23990-23993 CC denotes and
T8370 23994-24008 JJ denotes time-dependent
T8371 24008-24009 -COMMA- denotes ,
T8372 24010-24014 IN denotes with
T8373 24015-24016 DT denotes a
T8374 24017-24021 JJ denotes peak
T8375 24022-24028 NN denotes effect
T8376 24029-24031 IN denotes of
T8377 24032-24041 RB denotes 11.6-fold
T8378 24042-24044 IN denotes at
T8379 24045-24047 CD denotes 30
T8380 24048-24051 NN denotes min
T8381 24052-24054 IN denotes at
T8382 24055-24056 DT denotes a
T8383 24057-24070 NN denotes concentration
T8384 24071-24073 IN denotes of
T8385 24074-24078 CD denotes 10−8
T8386 24079-24080 NN denotes M
T8387 24081-24082 -LRB- denotes (
T8388 24082-24088 NN denotes Figure
T8389 24089-24091 NN denotes 1C
T8390 24091-24092 -RRB- denotes )
T8391 24093-24096 CC denotes and
T8392 24097-24100 VB denotes was
T8393 24101-24111 VB denotes associated
T8394 24112-24116 IN denotes with
T8395 24117-24123 JJ denotes marked
T8396 24124-24134 NN denotes reductions
T8397 24135-24137 IN denotes in
T8398 24138-24162 JJ denotes anti-CD3/CD28–stimulated
T8399 24163-24167 NN denotes IL-4
T8400 24168-24171 CC denotes and
T8401 24172-24176 NN denotes IL-5
T8402 24177-24181 NN denotes mRNA
T8403 24182-24192 NN denotes expression
T8404 24193-24194 -LRB- denotes (
T8405 24194-24200 NN denotes Figure
T8406 24201-24203 NN denotes 1D
T8407 24203-24204 -RRB- denotes )
T8408 24205-24208 CC denotes and
T8409 24209-24210 DT denotes a
T8410 24211-24215 NN denotes loss
T8411 24216-24218 IN denotes of
T8412 24219-24225 NN denotes GATA-3
T8413 24226-24233 NN denotes binding
T8414 24234-24236 TO denotes to
T8415 24237-24240 DT denotes the
T8416 24241-24247 JJ denotes native
T8417 24248-24252 NN denotes IL-5
T8418 24253-24261 NN denotes promoter
T8419 24262-24263 -LRB- denotes (
T8420 24263-24269 NN denotes Figure
T8421 24270-24272 NN denotes 1E
T8422 24272-24273 -RRB- denotes )
T8946 25824-25840 JJ denotes Ligand-Activated
T8947 25841-25843 NN denotes GR
T8948 25844-25852 VB denotes Competes
T8949 25853-25857 IN denotes with
T8950 25858-25864 NN denotes GATA-3
T8951 25865-25868 IN denotes for
T8952 25869-25879 NN denotes Importin-α
T8953 25880-25882 PRP denotes We
T8954 25883-25892 VB denotes confirmed
T8955 25893-25896 CC denotes and
T8956 25897-25905 VB denotes extended
T8957 25906-25914 JJ denotes previous
T8958 25915-25919 NN denotes data
T8959 25920-25921 -LRB- denotes [
T8960 25921-25923 CD denotes 20
T8961 25923-25924 -RRB- denotes ]
T8962 25925-25927 TO denotes to
T8963 25928-25932 VB denotes show
T8964 25933-25937 IN denotes that
T8965 25938-25954 JJ denotes ligand-activated
T8966 25955-25957 NN denotes GR
T8967 25958-25960 RB denotes as
T8968 25961-25965 RB denotes well
T8969 25966-25968 IN denotes as
T8970 25969-25975 NN denotes GATA-3
T8971 25976-25980 VB denotes uses
T8972 25981-25991 JJ denotes importin-α
T8973 25992-25995 IN denotes for
T8974 25996-25999 PRP-DOLLAR- denotes its
T8975 26000-26007 JJ denotes nuclear
T8976 26008-26014 NN denotes import
T8977 26015-26016 -LRB- denotes (
T8978 26016-26022 NN denotes Figure
T8979 26023-26025 NN denotes 2A
T8980 26026-26029 CC denotes and
T8981 26030-26032 NN denotes 2B
T8982 26032-26033 -RRB- denotes )
T8983 26035-26039 DT denotes This
T8984 26040-26051 NN denotes interaction
T8985 26052-26059 IN denotes between
T8986 26060-26062 NN denotes GR
T8987 26063-26066 CC denotes and
T8988 26067-26077 NN denotes importin-α
T8989 26078-26081 VB denotes was
T8990 26082-26093 JJ denotes significant
T8991 26094-26096 IN denotes at
T8992 26097-26111 NN denotes concentrations
T8993 26112-26114 RB denotes as
T8994 26115-26118 JJ denotes low
T8995 26119-26121 IN denotes as
T8996 26122-26127 CD denotes 10−12
T8997 26128-26129 NN denotes M
T8998 26130-26133 CC denotes and
T8999 26134-26137 VB denotes was
T9000 26138-26145 JJ denotes maximal
T9001 26146-26150 IN denotes with
T9002 26151-26155 CD denotes 10−8
T9003 26156-26157 NN denotes M
T9004 26158-26160 NN denotes FP
T9005 26162-26172 JJ denotes Subsequent
T9006 26173-26175 NN denotes GR
T9007 26176-26183 JJ denotes nuclear
T9008 26184-26197 NN denotes translocation
T9009 26198-26201 VB denotes was
T9010 26202-26207 JJ denotes rapid
T9011 26208-26211 CC denotes and
T9012 26212-26221 JJ denotes sustained
T9013 26222-26224 IN denotes at
T9014 26225-26236 JJ denotes significant
T9015 26237-26243 NN denotes levels
T9016 26244-26247 IN denotes for
T9017 26248-26250 IN denotes at
T9018 26251-26256 JJ denotes least
T9019 26257-26259 CD denotes 14
T9020 26260-26261 NN denotes h
T9021 26262-26263 -LRB- denotes (
T9022 26263-26269 NN denotes Figure
T9023 26270-26272 NN denotes 2B
T9024 26272-26273 -RRB- denotes )
T9025 26275-26280 VB denotes Using
T9026 26281-26291 JJ denotes IP-Western
T9027 26292-26300 NN denotes blotting
T9028 26301-26303 PRP denotes we
T9029 26304-26310 VB denotes showed
T9030 26311-26315 IN denotes that
T9031 26316-26318 NN denotes FP
T9032 26319-26321 IN denotes at
T9033 26322-26332 CD denotes 10−12–10−8
T9034 26333-26334 NN denotes M
T9035 26335-26344 VB denotes decreased
T9036 26345-26348 DT denotes the
T9037 26349-26360 NN denotes association
T9038 26361-26368 IN denotes between
T9039 26369-26375 NN denotes GATA-3
T9040 26376-26379 CC denotes and
T9041 26380-26390 NN denotes importin-α
T9042 26391-26398 VB denotes induced
T9043 26399-26401 IN denotes by
T9044 26402-26415 JJ denotes anti-CD3/CD28
T9045 26416-26427 NN denotes stimulation
T9046 26428-26430 IN denotes in
T9047 26431-26432 DT denotes a
T9048 26433-26456 JJ denotes concentration-dependent
T9049 26457-26463 NN denotes manner
T9050 26464-26465 -LRB- denotes (
T9051 26465-26471 NN denotes Figure
T9052 26472-26474 NN denotes 2C
T9053 26474-26475 -RRB- denotes )
T9054 26477-26479 IN denotes In
T9055 26480-26488 NN denotes addition
T9056 26488-26489 -COMMA- denotes ,
T9057 26490-26495 VB denotes using
T9058 26496-26508 JJ denotes GFP-labelled
T9059 26509-26515 NN denotes GATA-3
T9060 26516-26519 CC denotes and
T9061 26520-26528 JJ denotes confocal
T9062 26529-26539 NN denotes microscopy
T9063 26540-26542 PRP denotes we
T9064 26543-26555 VB denotes demonstrated
T9065 26556-26560 IN denotes that
T9066 26561-26567 NN denotes GATA-3
T9067 26568-26575 JJ denotes nuclear
T9068 26576-26582 NN denotes import
T9069 26583-26592 VB denotes following
T9070 26593-26606 JJ denotes anti-CD3/CD28
T9071 26607-26618 NN denotes stimulation
T9072 26619-26622 IN denotes for
T9073 26623-26625 CD denotes 30
T9074 26626-26629 NN denotes min
T9075 26630-26633 VB denotes was
T9076 26634-26644 VB denotes attenuated
T9077 26645-26647 IN denotes by
T9078 26648-26660 NN denotes pretreatment
T9079 26661-26665 IN denotes with
T9080 26666-26668 NN denotes FP
T9081 26669-26670 -LRB- denotes (
T9082 26670-26674 CD denotes 10−8
T9083 26675-26676 NN denotes M
T9084 26676-26677 -RRB- denotes )
T9085 26678-26679 -LRB- denotes (
T9086 26679-26685 NN denotes Figure
T9087 26686-26688 NN denotes 2D
T9088 26688-26689 -RRB- denotes )
T9702 28251-28257 NN denotes Effect
T9703 28258-28260 IN denotes on
T9704 28261-28266 NN denotes MKP-1
T9705 28267-28280 NN denotes Dexamethasone
T9706 28281-28289 VB denotes inhibits
T9707 28290-28293 NN denotes p38
T9708 28294-28298 NN denotes MAPK
T9709 28299-28307 NN denotes function
T9710 28308-28310 IN denotes in
T9711 28311-28312 DT denotes a
T9712 28313-28317 NN denotes cell
T9713 28318-28331 JJ denotes type–specific
T9714 28332-28338 NN denotes manner
T9715 28339-28346 IN denotes through
T9716 28347-28350 DT denotes the
T9717 28351-28356 JJ denotes rapid
T9718 28357-28366 NN denotes induction
T9719 28367-28369 IN denotes of
T9720 28370-28373 DT denotes the
T9721 28374-28378 JJ denotes dual
T9722 28379-28385 NN denotes kinase
T9723 28386-28397 NN denotes phosphatase
T9724 28398-28403 NN denotes MKP-1
T9725 28404-28405 -LRB- denotes (
T9726 28405-28409 NN denotes MAPK
T9727 28410-28423 NN denotes phosphatase-1
T9728 28423-28424 -RRB- denotes )
T9729 28424-28425 -COMMA- denotes ,
T9730 28426-28429 CC denotes and
T9731 28430-28434 DT denotes this
T9732 28435-28441 NN denotes effect
T9733 28442-28447 VB denotes lasts
T9734 28448-28451 IN denotes for
T9735 28452-28454 RB denotes up
T9736 28455-28457 TO denotes to
T9737 28458-28460 CD denotes 24
T9738 28461-28462 NN denotes h
T9739 28463-28464 -LRB- denotes [
T9740 28464-28466 CD denotes 28
T9741 28466-28467 -RRB- denotes ]
T9742 28469-28471 NN denotes FP
T9743 28472-28473 -LRB- denotes (
T9744 28473-28477 CD denotes 10−8
T9745 28478-28479 NN denotes M
T9746 28479-28480 -RRB- denotes )
T9747 28481-28490 NN denotes treatment
T9748 28491-28493 IN denotes of
T9749 28494-28500 NN denotes HuT-78
T9750 28501-28506 NN denotes cells
T9751 28507-28516 VB denotes activated
T9752 28517-28519 IN denotes by
T9753 28520-28533 JJ denotes anti-CD3/CD28
T9754 28534-28536 FW denotes in
T9755 28537-28542 FW denotes vitro
T9756 28543-28556 RB denotes significantly
T9757 28557-28566 VB denotes decreased
T9758 28567-28570 NN denotes p38
T9759 28571-28575 NN denotes MAPK
T9760 28576-28591 NN denotes phosphorylation
T9761 28592-28593 -LRB- denotes (
T9762 28593-28599 NN denotes Figure
T9763 28600-28602 NN denotes 3A
T9764 28602-28603 -RRB- denotes )
T9765 28604-28607 CC denotes and
T9766 28608-28616 NN denotes activity
T9767 28617-28625 VB denotes measured
T9768 28626-28628 IN denotes by
T9769 28629-28644 NN denotes phosphorylation
T9770 28645-28647 IN denotes of
T9771 28648-28651 DT denotes the
T9772 28652-28662 JJ denotes downstream
T9773 28663-28669 NN denotes target
T9774 28670-28675 NN denotes ATF-2
T9775 28676-28677 -LRB- denotes (
T9776 28677-28683 NN denotes Figure
T9777 28684-28686 NN denotes 3B
T9778 28686-28687 -RRB- denotes )
T9779 28689-28693 DT denotes This
T9780 28694-28700 NN denotes effect
T9781 28701-28704 VB denotes was
T9782 28705-28713 VB denotes detected
T9783 28714-28716 IN denotes at
T9784 28717-28719 CD denotes 30
T9785 28720-28723 NN denotes min
T9786 28724-28727 CC denotes and
T9787 28728-28734 VB denotes lasted
T9788 28735-28738 IN denotes for
T9789 28739-28741 IN denotes at
T9790 28742-28747 JJ denotes least
T9791 28748-28750 CD denotes 14
T9792 28751-28752 NN denotes h
T9793 28753-28754 -LRB- denotes (
T9794 28754-28760 NN denotes Figure
T9795 28761-28763 NN denotes 3B
T9796 28763-28764 -RRB- denotes )
T9797 28766-28768 NN denotes FP
T9798 28769-28770 -LRB- denotes (
T9799 28770-28774 CD denotes 10−8
T9800 28775-28776 NN denotes M
T9801 28776-28777 -RRB- denotes )
T9802 28778-28782 RB denotes also
T9803 28783-28796 RB denotes significantly
T9804 28797-28804 VB denotes reduced
T9805 28805-28811 NN denotes GATA-3
T9806 28812-28818 NN denotes serine
T9807 28819-28834 NN denotes phosphorylation
T9808 28835-28842 VB denotes induced
T9809 28843-28845 IN denotes by
T9810 28846-28859 JJ denotes anti-CD3/CD28
T9811 28860-28871 NN denotes stimulation
T9812 28872-28874 IN denotes in
T9813 28875-28879 CC denotes both
T9814 28880-28881 DT denotes a
T9815 28882-28887 NN denotes time-
T9816 28888-28891 CC denotes and
T9817 28892-28915 JJ denotes concentration-dependent
T9818 28916-28922 NN denotes manner
T9819 28923-28924 -LRB- denotes (
T9820 28924-28930 NN denotes Figure
T9821 28931-28933 NN denotes 3C
T9822 28933-28934 -RRB- denotes )
T9823 28936-28940 DT denotes This
T9824 28941-28950 NN denotes reduction
T9825 28951-28953 IN denotes in
T9826 28954-28960 NN denotes GATA-3
T9827 28961-28976 NN denotes phosphorylation
T9828 28977-28980 VB denotes was
T9829 28981-28985 RB denotes also
T9830 28986-28990 VB denotes seen
T9831 28991-28995 IN denotes with
T9832 28996-29001 JJ denotes lower
T9833 29002-29016 NN denotes concentrations
T9834 29017-29019 IN denotes of
T9835 29020-29022 NN denotes FP
T9836 29024-29026 PRP denotes We
T9837 29027-29032 VB denotes found
T9838 29033-29037 IN denotes that
T9839 29038-29040 NN denotes FP
T9840 29041-29054 RB denotes significantly
T9841 29055-29062 VB denotes induced
T9842 29063-29068 NN denotes MKP-1
T9843 29069-29073 NN denotes mRNA
T9844 29074-29076 IN denotes in
T9845 29077-29081 CC denotes both
T9846 29082-29083 DT denotes a
T9847 29084-29089 NN denotes time-
T9848 29090-29093 CC denotes and
T9849 29094-29117 JJ denotes concentration-dependent
T9850 29118-29124 NN denotes manner
T9851 29124-29125 -COMMA- denotes ,
T9852 29126-29134 VB denotes reaching
T9853 29135-29136 DT denotes a
T9854 29137-29144 NN denotes plateau
T9855 29145-29147 IN denotes at
T9856 29148-29152 CD denotes 10−8
T9857 29153-29154 NN denotes M
T9858 29155-29160 IN denotes after
T9859 29161-29163 CD denotes 10
T9860 29164-29167 NN denotes min
T9861 29168-29169 -LRB- denotes (
T9862 29169-29175 NN denotes Figure
T9863 29176-29178 NN denotes 3D
T9864 29179-29182 CC denotes and
T9865 29183-29185 NN denotes 3E
T9866 29185-29186 -RRB- denotes )
T9867 29188-29195 RB denotes However
T9868 29195-29196 -COMMA- denotes ,
T9869 29197-29200 DT denotes the
T9870 29201-29208 NN denotes effects
T9871 29209-29211 IN denotes of
T9872 29212-29214 NN denotes FP
T9873 29215-29217 IN denotes on
T9874 29218-29224 NN denotes GATA-3
T9875 29225-29232 JJ denotes nuclear
T9876 29233-29239 NN denotes import
T9877 29239-29240 -COMMA- denotes ,
T9878 29241-29251 JJ denotes importin-α
T9879 29252-29263 NN denotes association
T9880 29264-29267 CC denotes and
T9881 29268-29272 NN denotes IL-4
T9882 29273-29277 NN denotes mRNA
T9883 29278-29288 NN denotes expression
T9884 29289-29292 VB denotes are
T9885 29293-29297 VB denotes seen
T9886 29298-29300 IN denotes at
T9887 29301-29312 RB denotes 10,000-fold
T9888 29313-29318 JJ denotes lower
T9889 29319-29333 NN denotes concentrations
T9890 29334-29335 -LRB- denotes (
T9891 29335-29340 CD denotes 10−12
T9892 29341-29342 NN denotes M
T9893 29342-29343 -COMMA- denotes ,
T9894 29344-29347 VB denotes see
T9895 29348-29354 NN denotes Figure
T9896 29355-29356 CD denotes 2
T9897 29356-29357 -RRB- denotes )
T9898 30668-30673 VB denotes Using
T9899 30674-30676 DT denotes an
T9900 30677-30679 FW denotes in
T9901 30680-30685 FW denotes vitro
T9902 30686-30697 NN denotes competition
T9903 30698-30703 NN denotes assay
T9904 30704-30705 -LRB- denotes (
T9905 30705-30711 NN denotes Figure
T9906 30712-30714 NN denotes 4A
T9907 30714-30715 -RRB- denotes )
T9908 30716-30725 VB denotes utilizing
T9909 30726-30734 VB denotes purified
T9910 30735-30744 VB denotes activated
T9911 30745-30751 NN denotes GATA-3
T9912 30751-30752 -COMMA- denotes ,
T9913 30753-30763 NN denotes importin-α
T9914 30763-30764 -COMMA- denotes ,
T9915 30765-30768 CC denotes and
T9916 30769-30778 VB denotes activated
T9917 30779-30781 NN denotes GR
T9918 30781-30782 -COMMA- denotes ,
T9919 30783-30785 PRP denotes we
T9920 30786-30798 VB denotes demonstrated
T9921 30799-30803 IN denotes that
T9922 30804-30813 VB denotes activated
T9923 30814-30816 NN denotes GR
T9924 30817-30830 RB denotes significantly
T9925 30831-30840 VB denotes increased
T9926 30841-30854 JJ denotes GR-importin-α
T9927 30855-30866 NN denotes association
T9928 30867-30869 IN denotes in
T9929 30870-30873 DT denotes the
T9930 30874-30882 NN denotes presence
T9931 30883-30886 CC denotes and
T9932 30887-30894 NN denotes absence
T9933 30895-30897 IN denotes of
T9934 30898-30907 VB denotes activated
T9935 30908-30914 NN denotes GATA-3
T9936 30915-30916 -LRB- denotes (
T9937 30916-30922 NN denotes Figure
T9938 30923-30925 NN denotes 4B
T9939 30925-30926 -RRB- denotes )
T9940 30928-30932 DT denotes This
T9941 30933-30939 NN denotes effect
T9942 30940-30942 VB denotes is
T9943 30943-30946 RB denotes not
T9944 30947-30953 JJ denotes mutual
T9945 30953-30954 -COMMA- denotes ,
T9946 30955-30960 IN denotes since
T9947 30961-30970 VB denotes activated
T9948 30971-30977 NN denotes GATA-3
T9949 30978-30981 VB denotes did
T9950 30982-30985 RB denotes not
T9951 30986-30991 VB denotes block
T9952 30992-31005 JJ denotes GR–importin-α
T9953 31006-31017 NN denotes association
T9954 31018-31019 -LRB- denotes (
T9955 31019-31025 NN denotes Figure
T9956 31026-31028 NN denotes 4C
T9957 31028-31029 -RRB- denotes )
T9958 31031-31036 DT denotes These
T9959 31037-31041 NN denotes data
T9960 31042-31046 RB denotes also
T9961 31047-31054 VB denotes suggest
T9962 31055-31059 IN denotes that
T9963 31060-31064 CC denotes both
T9964 31065-31074 VB denotes activated
T9965 31075-31077 NN denotes GR
T9966 31078-31081 CC denotes and
T9967 31082-31096 NN denotes phospho-GATA-3
T9968 31097-31100 MD denotes can
T9969 31101-31109 RB denotes directly
T9970 31110-31119 VB denotes associate
T9971 31120-31124 IN denotes with
T9972 31125-31135 JJ denotes importin-α
T9973 31136-31137 -LRB- denotes (
T9974 31137-31143 NN denotes Figure
T9975 31144-31146 NN denotes 4D
T9976 31146-31147 -RRB- denotes )
T9977 31148-31151 CC denotes and
T9978 31152-31156 IN denotes that
T9979 31157-31166 VB denotes activated
T9980 31167-31169 NN denotes GR
T9981 31170-31180 VB denotes attenuates
T9982 31181-31184 DT denotes the
T9983 31185-31210 JJ denotes phospho-GATA-3/importin-α
T9984 31211-31222 NN denotes interaction
T9985 31223-31225 IN denotes in
T9986 31226-31227 DT denotes a
T9987 31228-31251 JJ denotes concentration-dependent
T9988 31252-31258 NN denotes manner
T9989 31259-31260 -LRB- denotes (
T9990 31260-31266 NN denotes Figure
T9991 31267-31269 NN denotes 4E
T9992 31269-31270 -RRB- denotes )
T9993 31272-31280 RB denotes Together
T9994 31280-31281 -COMMA- denotes ,
T9995 31282-31286 DT denotes this
T9996 31287-31295 VB denotes suggests
T9997 31296-31300 IN denotes that
T9998 31301-31317 JJ denotes ligand-activated
T9999 31318-31320 NN denotes GR
T10000 31321-31324 MD denotes may
T10001 31325-31332 VB denotes compete
T10002 31333-31337 IN denotes with
T10003 31338-31352 NN denotes phospho-GATA-3
T10004 31353-31356 IN denotes for
T10005 31357-31367 JJ denotes importin-α
T10006 31368-31371 CC denotes and
T10007 31372-31379 RB denotes thereby
T10008 31380-31385 VB denotes limit
T10009 31386-31392 NN denotes GATA-3
T10010 31393-31400 JJ denotes nuclear
T10011 31401-31407 NN denotes import
T10012 32497-32502 JJ denotes Other
T10013 32503-32511 JJ denotes possible
T10014 32512-32527 NN denotes interpretations
T10015 32528-32530 IN denotes of
T10016 32531-32534 PRP-DOLLAR- denotes our
T10017 32535-32542 NN denotes results
T10018 32543-32548 MD denotes could
T10019 32549-32556 VB denotes include
T10020 32557-32559 DT denotes an
T10021 32560-32566 NN denotes effect
T10022 32567-32569 IN denotes of
T10023 32570-32572 NN denotes FP
T10024 32573-32575 IN denotes on
T10025 32576-32582 NN denotes GATA-3
T10026 32583-32590 JJ denotes nuclear
T10027 32591-32597 NN denotes export
T10028 32598-32604 CC denotes and/or
T10029 32605-32616 NN denotes degradation
T10030 32618-32628 NNP denotes Leptomycin
T10031 32629-32630 NNP denotes B
T10032 32630-32631 -COMMA- denotes ,
T10033 32632-32637 WDT denotes which
T10034 32638-32646 VB denotes inhibits
T10035 32647-32654 JJ denotes nuclear
T10036 32655-32661 NN denotes export
T10037 32661-32662 -COMMA- denotes ,
T10038 32663-32666 VB denotes did
T10039 32667-32670 RB denotes not
T10040 32671-32677 VB denotes affect
T10041 32678-32681 DT denotes the
T10042 32682-32689 NN denotes ability
T10043 32690-32692 IN denotes of
T10044 32693-32695 NN denotes FP
T10045 32696-32698 TO denotes to
T10046 32699-32704 VB denotes block
T10047 32705-32711 NN denotes GATA-3
T10048 32712-32719 JJ denotes nuclear
T10049 32720-32732 NN denotes localization
T10050 32733-32734 -LRB- denotes (
T10051 32734-32740 NN denotes Figure
T10052 32741-32743 NN denotes 5A
T10053 32743-32744 -RRB- denotes )
T10054 32746-32758 RB denotes Additionally
T10055 32758-32759 -COMMA- denotes ,
T10056 32760-32762 NN denotes FP
T10057 32763-32766 VB denotes had
T10058 32767-32769 DT denotes no
T10059 32770-32776 NN denotes effect
T10060 32777-32779 IN denotes on
T10061 32780-32785 JJ denotes whole
T10062 32786-32790 NN denotes cell
T10063 32791-32797 NN denotes GATA-3
T10064 32798-32808 NN denotes expression
T10065 32809-32815 IN denotes during
T10066 32816-32819 DT denotes the
T10067 32820-32824 NN denotes time
T10068 32825-32831 NN denotes course
T10069 32832-32834 IN denotes of
T10070 32835-32840 DT denotes these
T10071 32841-32852 NN denotes experiments
T10072 32853-32854 -LRB- denotes (
T10073 32854-32860 NN denotes Figure
T10074 32861-32863 NN denotes 5B
T10075 32863-32864 -RRB- denotes )
T10076 32866-32869 CC denotes Nor
T10077 32870-32873 VB denotes did
T10078 32874-32882 NN denotes addition
T10079 32883-32885 IN denotes of
T10080 32886-32888 NN denotes FP
T10081 32889-32899 JJ denotes subsequent
T10082 32900-32902 TO denotes to
T10083 32903-32916 JJ denotes anti-CD3/CD28
T10084 32917-32924 JJ denotes nuclear
T10085 32925-32938 NN denotes translocation
T10086 32939-32945 VB denotes affect
T10087 32946-32952 NN denotes GATA-3
T10088 32953-32960 JJ denotes nuclear
T10089 32961-32970 NN denotes residency
T10090 32971-32972 -LRB- denotes (
T10091 32972-32978 NN denotes Figure
T10092 32979-32981 NN denotes 5C
T10093 32981-32982 -RRB- denotes )
T10094 32982-32983 -COMMA- denotes ,
T10095 32984-32994 VB denotes suggesting
T10096 32995-32999 IN denotes that
T10097 33000-33009 VB denotes activated
T10098 33010-33012 NN denotes GR
T10099 33013-33017 VB denotes does
T10100 33018-33021 RB denotes not
T10101 33022-33029 VB denotes enhance
T10102 33030-33036 NN denotes GATA-3
T10103 33037-33044 JJ denotes nuclear
T10104 33045-33051 NN denotes export
T10105 33053-33060 RB denotes Finally
T10106 33060-33061 -COMMA- denotes ,
T10107 33062-33065 DT denotes the
T10108 33066-33072 NN denotes effect
T10109 33073-33075 IN denotes of
T10110 33076-33078 NN denotes FP
T10111 33079-33081 IN denotes on
T10112 33082-33088 NN denotes GATA-3
T10113 33089-33096 JJ denotes nuclear
T10114 33097-33103 NN denotes import
T10115 33104-33107 VB denotes was
T10116 33108-33111 RB denotes not
T10117 33112-33123 JJ denotes nonspecific
T10118 33123-33124 -COMMA- denotes ,
T10119 33125-33130 IN denotes since
T10120 33131-33133 NN denotes FP
T10121 33134-33135 -LRB- denotes (
T10122 33135-33139 CD denotes 10−8
T10123 33140-33141 NN denotes M
T10124 33141-33142 -RRB- denotes )
T10125 33143-33146 VB denotes had
T10126 33147-33149 DT denotes no
T10127 33150-33156 NN denotes effect
T10128 33157-33159 IN denotes on
T10129 33160-33163 NN denotes p65
T10130 33164-33171 JJ denotes nuclear
T10131 33172-33185 NN denotes translocation
T10132 33186-33194 VB denotes measured
T10133 33195-33197 IN denotes at
T10134 33198-33200 CD denotes 60
T10135 33201-33204 NN denotes min
T10136 33205-33206 -LRB- denotes (
T10137 33206-33212 NN denotes Figure
T10138 33213-33215 NN denotes 5D
T10139 33215-33216 -RRB- denotes )
T11309 34269-34272 DT denotes The
T11310 34273-34283 JJ denotes Inhibitory
T11311 34284-34290 NN denotes Effect
T11312 34291-34293 IN denotes of
T11313 34294-34309 NN denotes Corticosteroids
T11314 34310-34312 IN denotes on
T11315 34313-34319 NN denotes GATA-3
T11316 34320-34327 JJ denotes Nuclear
T11317 34328-34340 NN denotes Localization
T11318 34341-34343 IN denotes in
T11319 34344-34351 JJ denotes Primary
T11320 34352-34353 NN denotes T
T11321 34354-34365 NN denotes Lymphocytes
T11322 34366-34368 NNP denotes Ex
T11323 34369-34373 NNP denotes Vivo
T11324 34374-34377 CC denotes and
T11325 34378-34380 IN denotes In
T11326 34381-34385 FW denotes Vivo
T11327 34386-34395 NN denotes Treatment
T11328 34396-34400 IN denotes with
T11329 34401-34403 NN denotes FP
T11330 34404-34406 FW denotes ex
T11331 34407-34411 FW denotes vivo
T11332 34412-34424 VB denotes demonstrated
T11333 34425-34426 DT denotes a
T11334 34427-34450 JJ denotes concentration-dependent
T11335 34451-34459 NN denotes decrease
T11336 34460-34462 IN denotes in
T11337 34463-34466 DT denotes the
T11338 34467-34473 JJ denotes direct
T11339 34474-34485 NN denotes interaction
T11340 34486-34493 IN denotes between
T11341 34494-34508 NN denotes phospho-GATA-3
T11342 34509-34512 CC denotes and
T11343 34513-34523 NN denotes importin-α
T11344 34524-34526 IN denotes in
T11345 34527-34532 NN denotes PBMCs
T11346 34533-34537 IN denotes from
T11347 34538-34546 NN denotes patients
T11348 34547-34551 IN denotes with
T11349 34552-34558 NN denotes asthma
T11350 34559-34560 -LRB- denotes (
T11351 34560-34566 NN denotes Figure
T11352 34567-34569 NN denotes 6A
T11353 34570-34573 CC denotes and
T11354 34574-34576 NN denotes 6B
T11355 34576-34577 -RRB- denotes )
T11356 34577-34578 -COMMA- denotes ,
T11357 34579-34584 WDT denotes which
T11358 34585-34588 VB denotes was
T11359 34589-34602 RB denotes significantly
T11360 34603-34612 VB denotes inhibited
T11361 34613-34615 IN denotes at
T11362 34616-34621 CD denotes 10−12
T11363 34622-34623 NN denotes M
T11364 34624-34626 NN denotes FP
T11365 34627-34628 -LRB- denotes (
T11366 34628-34629 NN denotes p
T11367 34629-34630 JJ denotes <
T11368 34630-34635 CD denotes 0.001
T11369 34635-34636 -COMMA- denotes ,
T11370 34637-34642 NN denotes ANOVA
T11371 34643-34646 CC denotes and
T11372 34647-34659 NNP denotes Newman-Keuls
T11373 34660-34664 NN denotes test
T11374 34664-34665 -RRB- denotes )
T11375 34666-34669 CC denotes and
T11376 34670-34680 RB denotes completely
T11377 34681-34691 VB denotes attenuated
T11378 34692-34694 IN denotes by
T11379 34695-34699 CD denotes 10−8
T11380 34700-34701 NN denotes M
T11381 34702-34704 NN denotes FP
T11382 34705-34706 -LRB- denotes (
T11383 34706-34707 NN denotes p
T11384 34707-34708 JJ denotes <
T11385 34708-34713 CD denotes 0.001
T11386 34713-34714 -COMMA- denotes ,
T11387 34715-34720 NN denotes ANOVA
T11388 34721-34724 CC denotes and
T11389 34725-34737 NNP denotes Newman-Keuls
T11390 34738-34742 NN denotes test
T11391 34742-34743 -RRB- denotes )
T11392 35694-35697 PRP-DOLLAR- denotes Our
T11393 35698-35706 JJ denotes previous
T11394 35707-35708 NN denotes T
T11395 35709-35713 NN denotes cell
T11396 35714-35718 NN denotes line
T11397 35719-35726 NN denotes studies
T11398 35727-35736 VB denotes indicated
T11399 35737-35741 IN denotes that
T11400 35742-35747 CD denotes 10−12
T11401 35748-35749 NN denotes M
T11402 35750-35752 NN denotes FP
T11403 35753-35763 VB denotes suppresses
T11404 35764-35768 NN denotes IL-4
T11405 35769-35772 CC denotes and
T11406 35773-35775 CD denotes -5
T11407 35776-35780 NN denotes gene
T11408 35781-35791 NN denotes expression
T11409 35792-35795 CC denotes and
T11410 35796-35806 VB denotes attenuated
T11411 35807-35810 DT denotes the
T11412 35811-35822 NN denotes interaction
T11413 35823-35825 IN denotes of
T11414 35826-35832 NN denotes GATA-3
T11415 35833-35837 IN denotes with
T11416 35838-35848 NN denotes importin-α
T11417 35849-35850 -LRB- denotes (
T11418 35850-35853 VB denotes see
T11419 35854-35861 NN denotes Figures
T11420 35862-35864 NN denotes 1D
T11421 35865-35868 CC denotes and
T11422 35869-35870 CD denotes 2
T11423 35870-35871 -RRB- denotes )
T11424 35873-35877 DT denotes This
T11425 35878-35891 NN denotes concentration
T11426 35892-35894 VB denotes is
T11427 35895-35900 JJ denotes close
T11428 35901-35903 TO denotes to
T11429 35904-35908 JJ denotes peak
T11430 35909-35915 NN denotes plasma
T11431 35916-35922 NN denotes levels
T11432 35923-35931 VB denotes obtained
T11433 35932-35936 IN denotes from
T11434 35937-35946 JJ denotes asthmatic
T11435 35947-35955 NN denotes patients
T11436 35956-35963 VB denotes treated
T11437 35964-35968 IN denotes with
T11438 35969-35976 VB denotes inhaled
T11439 35977-35979 NN denotes FP
T11440 35980-35981 -LRB- denotes (
T11441 35981-35984 CD denotes 500
T11442 35985-35987 NN denotes µg
T11443 35987-35988 -RRB- denotes )
T11444 35989-35990 -LRB- denotes [
T11445 35990-35992 CD denotes 27
T11446 35992-35993 -RRB- denotes ]
T11447 35995-36002 VB denotes Inhaled
T11448 36003-36005 NN denotes FP
T11449 36006-36007 -LRB- denotes (
T11450 36007-36010 CD denotes 500
T11451 36011-36013 NN denotes µg
T11452 36013-36014 -RRB- denotes )
T11453 36015-36024 NN denotes treatment
T11454 36025-36027 IN denotes of
T11455 36028-36033 CD denotes seven
T11456 36034-36047 JJ denotes steroid-naive
T11457 36048-36054 NN denotes asthma
T11458 36055-36063 NN denotes patients
T11459 36064-36077 RB denotes significantly
T11460 36078-36085 VB denotes reduced
T11461 36086-36103 NN denotes GATA-3–importin-α
T11462 36104-36115 NN denotes interaction
T11463 36116-36118 FW denotes in
T11464 36119-36123 FW denotes vivo
T11465 36124-36126 IN denotes in
T11466 36127-36128 DT denotes a
T11467 36129-36143 JJ denotes time-dependent
T11468 36144-36150 NN denotes manner
T11469 36152-36156 DT denotes This
T11470 36157-36165 VB denotes produced
T11471 36166-36167 DT denotes a
T11472 36168-36169 JJ denotes >
T11473 36169-36171 CD denotes 90
T11474 36171-36172 NN denotes %
T11475 36173-36181 NN denotes decrease
T11476 36182-36184 IN denotes in
T11477 36185-36202 NN denotes GATA-3–importin-α
T11478 36203-36214 NN denotes association
T11479 36215-36217 IN denotes at
T11480 36218-36219 CD denotes 2
T11481 36220-36221 NN denotes h
T11482 36222-36223 -LRB- denotes (
T11483 36223-36229 NN denotes median
T11484 36230-36231 -LRB- denotes [
T11485 36231-36233 CD denotes 95
T11486 36233-36234 NN denotes %
T11487 36235-36237 NN denotes CI
T11488 36237-36238 -RRB- denotes ]
T11489 36238-36239 -COMMA- denotes ,
T11490 36240-36246 CD denotes 13,494
T11491 36247-36248 -LRB- denotes [
T11492 36248-36260 CD denotes 6,828–17,829
T11493 36260-36261 -RRB- denotes ]
T11494 36262-36268 IN denotes versus
T11495 36269-36272 CD denotes 879
T11496 36273-36274 -LRB- denotes [
T11497 36274-36283 CD denotes 597–1,165
T11498 36283-36284 -RRB- denotes ]
T11499 36284-36285 -COLON- denotes ;
T11500 36286-36287 NN denotes p
T11501 36287-36288 SYM denotes <
T11502 36288-36292 CD denotes 0.05
T11503 36293-36301 NNP denotes Friedman
T11504 36301-36303 POS denotes 's
T11505 36304-36312 NN denotes analysis
T11506 36312-36313 -RRB- denotes )
T11507 36315-36322 RB denotes However
T11508 36322-36323 -COMMA- denotes ,
T11509 36324-36328 DT denotes this
T11510 36329-36332 VB denotes did
T11511 36333-36336 RB denotes not
T11512 36337-36342 VB denotes reach
T11513 36343-36355 NN denotes significance
T11514 36356-36361 VB denotes using
T11515 36362-36370 NNP denotes Wilcoxon
T11516 36370-36372 POS denotes 's
T11517 36373-36382 JJ denotes post-test
T11518 36383-36391 NN denotes analysis
T11519 36392-36393 -LRB- denotes (
T11520 36393-36401 NN denotes W = 6.00
T11521 36401-36402 -RRB- denotes )
T11522 36403-36411 RB denotes probably
T11523 36412-36415 JJ denotes due
T11524 36416-36418 TO denotes to
T11525 36419-36422 JJ denotes low
T11526 36423-36430 NN denotes numbers
T11527 36431-36433 IN denotes of
T11528 36434-36446 NN denotes participants
T11529 36448-36455 JJ denotes Similar
T11530 36456-36463 NN denotes results
T11531 36464-36468 VB denotes were
T11532 36469-36477 VB denotes observed
T11533 36478-36482 WRB denotes when
T11534 36483-36500 NN denotes GATA-3–importin-α
T11535 36501-36512 NN denotes association
T11536 36513-36516 VB denotes was
T11537 36517-36525 VB denotes measured
T11538 36526-36527 -LRB- denotes (
T11539 36527-36533 NN denotes Figure
T11540 36534-36536 NN denotes 6C
T11541 36537-36540 CC denotes and
T11542 36541-36543 NN denotes 6D
T11543 36543-36544 -RRB- denotes )
T11544 36546-36549 DT denotes The
T11545 36550-36555 JJ denotes lower
T11546 36556-36560 NN denotes dose
T11547 36561-36563 IN denotes of
T11548 36564-36566 NN denotes FP
T11549 36567-36568 -LRB- denotes (
T11550 36568-36571 CD denotes 100
T11551 36572-36574 NN denotes µg
T11552 36574-36575 -RRB- denotes )
T11553 36576-36579 VB denotes was
T11554 36580-36583 RB denotes not
T11555 36584-36593 JJ denotes effective
T11556 36595-36598 DT denotes The
T11557 36599-36609 JJ denotes attenuated
T11558 36610-36621 NN denotes interaction
T11559 36622-36624 IN denotes of
T11560 36625-36631 NN denotes GATA-3
T11561 36632-36635 VB denotes did
T11562 36636-36639 RB denotes not
T11563 36640-36646 VB denotes result
T11564 36647-36651 IN denotes from
T11565 36652-36655 DT denotes the
T11566 36656-36665 JJ denotes defective
T11567 36666-36675 NN denotes recycling
T11568 36676-36678 IN denotes of
T11569 36679-36689 NN denotes importin-α
T11570 36689-36690 -COMMA- denotes ,
T11571 36691-36693 IN denotes as
T11572 36694-36695 DT denotes a
T11573 36696-36707 JJ denotes significant
T11574 36708-36716 NN denotes decrease
T11575 36717-36719 IN denotes in
T11576 36720-36723 DT denotes the
T11577 36724-36733 NN denotes abundance
T11578 36734-36736 IN denotes of
T11579 36737-36747 NN denotes importin-α
T11580 36748-36750 IN denotes in
T11581 36751-36754 DT denotes the
T11582 36755-36766 JJ denotes cytoplasmic
T11583 36767-36771 NN denotes pool
T11584 36772-36775 VB denotes was
T11585 36776-36779 RB denotes not
T11586 36780-36788 VB denotes detected
T11587 36789-36790 -LRB- denotes (
T11588 36790-36796 NN denotes Figure
T11589 36797-36799 NN denotes 6E
T11590 36799-36800 -RRB- denotes )
T11591 36802-36804 PRP denotes We
T11592 36805-36812 RB denotes further
T11593 36813-36821 VB denotes examined
T11594 36822-36829 IN denotes whether
T11595 36830-36837 VB denotes inhaled
T11596 36838-36840 NN denotes FP
T11597 36841-36846 MD denotes could
T11598 36847-36853 VB denotes affect
T11599 36854-36862 JJ denotes cellular
T11600 36863-36875 NN denotes localization
T11601 36876-36878 IN denotes of
T11602 36879-36885 NN denotes GATA-3
T11603 36886-36888 IN denotes in
T11604 36889-36899 JJ denotes peripheral
T11605 36900-36905 NN denotes blood
T11606 36906-36907 NN denotes T
T11607 36908-36913 NN denotes cells
T11608 36915-36924 NN denotes Treatment
T11609 36925-36929 IN denotes with
T11610 36930-36937 VB denotes inhaled
T11611 36938-36940 NN denotes FP
T11612 36941-36942 -LRB- denotes (
T11613 36942-36945 CD denotes 500
T11614 36946-36948 NN denotes µg
T11615 36948-36949 -RRB- denotes )
T11616 36950-36953 IN denotes for
T11617 36954-36955 CD denotes 2
T11618 36956-36957 NN denotes h
T11619 36958-36971 RB denotes significantly
T11620 36972-36981 VB denotes increased
T11621 36982-36984 NN denotes GR
T11622 36985-36992 JJ denotes nuclear
T11623 36993-37006 NN denotes translocation
T11624 37007-37008 -LRB- denotes (
T11625 37008-37014 NN denotes Figure
T11626 37015-37017 NN denotes 7A
T11627 37017-37018 -RRB- denotes )
T11628 37019-37022 CC denotes and
T11629 37023-37036 RB denotes concomitantly
T11630 37037-37046 VB denotes decreased
T11631 37047-37050 DT denotes the
T11632 37051-37057 NN denotes number
T11633 37058-37060 IN denotes of
T11634 37061-37068 JJ denotes nuclear
T11635 37069-37075 NN denotes GATA-3
T11636 37076-37090 JJ denotes immunoreactive
T11637 37091-37101 JJ denotes peripheral
T11638 37102-37107 NN denotes blood
T11639 37108-37109 NN denotes T
T11640 37110-37115 NN denotes cells
T11641 37116-37117 -LRB- denotes (
T11642 37117-37119 CD denotes 37
T11643 37119-37120 NN denotes %
T11644 37120-37124 CD denotes ±4.2
T11645 37124-37125 NN denotes %
T11646 37126-37132 IN denotes versus
T11647 37133-37137 CD denotes 58.2
T11648 37137-37138 NN denotes %
T11649 37138-37143 CD denotes ±4.95
T11650 37143-37144 NN denotes %
T11651 37144-37145 -COMMA- denotes ,
T11652 37146-37155 NN denotes p = 0.016
T11653 37155-37156 -COMMA- denotes ,
T11654 37157-37165 NN denotes W = 28.0
T11655 37165-37166 -COMMA- denotes ,
T11656 37167-37175 NNP denotes Wilcoxon
T11657 37175-37177 POS denotes 's
T11658 37178-37182 NN denotes rank
T11659 37183-37187 NN denotes test
T11660 37187-37188 -RRB- denotes )
T11661 37189-37197 VB denotes compared
T11662 37198-37202 IN denotes with
T11663 37203-37210 NN denotes placebo
T11664 37211-37213 IN denotes as
T11665 37214-37222 VB denotes measured
T11666 37223-37225 IN denotes by
T11667 37226-37245 NN denotes immunocytochemistry
T11668 37246-37247 -LRB- denotes (
T11669 37247-37253 NN denotes Figure
T11670 37254-37256 NN denotes 7A
T11671 37257-37260 CC denotes and
T11672 37261-37263 NN denotes 7B
T11673 37263-37264 -RRB- denotes )
T11674 37266-37270 DT denotes This
T11675 37271-37274 VB denotes was
T11676 37275-37284 VB denotes confirmed
T11677 37285-37287 IN denotes by
T11678 37288-37295 JJ denotes Western
T11679 37296-37304 NN denotes blotting
T11680 37304-37305 -COMMA- denotes ,
T11681 37306-37311 WDT denotes which
T11682 37312-37316 RB denotes also
T11683 37317-37326 VB denotes indicated
T11684 37327-37331 IN denotes that
T11685 37332-37336 DT denotes this
T11686 37337-37343 NN denotes effect
T11687 37344-37347 VB denotes was
T11688 37348-37352 CC denotes both
T11689 37353-37358 NN denotes time-
T11690 37359-37362 CC denotes and
T11691 37363-37377 JJ denotes dose-dependent
T11692 37378-37379 -LRB- denotes (
T11693 37379-37385 NN denotes Figure
T11694 37386-37388 NN denotes 7C
T11695 37389-37392 CC denotes and
T11696 37393-37395 NN denotes 7D
T11697 37395-37396 -RRB- denotes )
T11698 37398-37402 RB denotes Thus
T11699 37402-37403 -COMMA- denotes ,
T11700 37404-37411 VB denotes inhaled
T11701 37412-37414 NN denotes FP
T11702 37415-37416 -LRB- denotes (
T11703 37416-37419 CD denotes 500
T11704 37420-37422 NN denotes µg
T11705 37422-37423 -RRB- denotes )
T11706 37424-37431 VB denotes induced
T11707 37432-37443 JJ denotes significant
T11708 37444-37448 NN denotes loss
T11709 37449-37451 IN denotes in
T11710 37452-37459 JJ denotes nuclear
T11711 37460-37466 NN denotes GATA-3
T11712 37467-37469 IN denotes at
T11713 37470-37471 CD denotes 2
T11714 37472-37473 NN denotes h
T11715 37474-37475 -LRB- denotes (
T11716 37475-37481 NN denotes median
T11717 37482-37483 -LRB- denotes [
T11718 37483-37485 CD denotes 95
T11719 37485-37486 NN denotes %
T11720 37487-37489 NN denotes CI
T11721 37489-37490 -RRB- denotes ]
T11722 37490-37491 -COMMA- denotes ,
T11723 37492-37496 CD denotes 0.40
T11724 37497-37498 -LRB- denotes [
T11725 37498-37507 CD denotes 0.27–0.53
T11726 37507-37508 -RRB- denotes ]
T11727 37509-37515 IN denotes versus
T11728 37516-37520 CD denotes 0.14
T11729 37521-37522 -LRB- denotes [
T11730 37522-37531 CD denotes 0.11–0.19
T11731 37531-37532 -RRB- denotes ]
T11732 37532-37533 -COMMA- denotes ,
T11733 37534-37535 NN denotes p
T11734 37535-37536 SYM denotes <
T11735 37536-37540 CD denotes 0.05
T11736 37540-37541 -COMMA- denotes ,
T11737 37542-37551 NN denotes W = 21.00
T11738 37551-37552 -COMMA- denotes ,
T11739 37553-37561 NNP denotes Wilcoxon
T11740 37561-37563 POS denotes 's
T11741 37564-37568 NN denotes rank
T11742 37569-37573 NN denotes test
T11743 37573-37574 -RRB- denotes )
T11744 37575-37576 -LRB- denotes (
T11745 37576-37582 NN denotes Figure
T11746 37583-37585 NN denotes 7C
T11747 37585-37586 -RRB- denotes )
T11748 37587-37590 CC denotes and
T11749 37591-37602 JJ denotes cytoplasmic
T11750 37603-37609 NN denotes GATA-3
T11751 37610-37616 NN denotes levels
T11752 37617-37621 VB denotes were
T11753 37622-37630 VB denotes enhanced
T11754 37631-37633 IN denotes by
T11755 37634-37641 VB denotes inhaled
T11756 37642-37644 NN denotes FP
T11757 37645-37647 IN denotes in
T11758 37648-37649 DT denotes a
T11759 37650-37664 JJ denotes dose-dependent
T11760 37665-37671 NN denotes manner
T11761 37672-37673 -LRB- denotes (
T11762 37673-37679 NN denotes median
T11763 37680-37681 -LRB- denotes [
T11764 37681-37683 CD denotes 95
T11765 37683-37684 NN denotes %
T11766 37685-37687 NN denotes CI
T11767 37687-37688 -RRB- denotes ]
T11768 37688-37689 -COMMA- denotes ,
T11769 37690-37696 CD denotes 0.0032
T11770 37697-37698 -LRB- denotes [
T11771 37698-37711 CD denotes 0.0026–0.0039
T11772 37711-37712 -RRB- denotes ]
T11773 37713-37719 IN denotes versus
T11774 37720-37725 CD denotes 0.658
T11775 37726-37727 -LRB- denotes [
T11776 37727-37738 CD denotes 0.592–0.720
T11777 37738-37739 -RRB- denotes ]
T11778 37739-37740 -COMMA- denotes ,
T11779 37741-37742 NN denotes p
T11780 37742-37743 SYM denotes <
T11781 37743-37747 CD denotes 0.05
T11782 37747-37748 -COMMA- denotes ,
T11783 37749-37759 NN denotes W = −21.00
T11784 37759-37760 -COMMA- denotes ,
T11785 37761-37769 NNP denotes Wilcoxon
T11786 37769-37771 POS denotes 's
T11787 37772-37776 NN denotes rank
T11788 37777-37781 NN denotes test
T11789 37781-37782 -RRB- denotes )
T11790 37783-37784 -LRB- denotes (
T11791 37784-37790 NN denotes Figure
T11792 37791-37793 NN denotes 7D
T11793 37793-37794 -RRB- denotes )
T11794 37796-37798 IN denotes In
T11795 37799-37807 NN denotes addition
T11796 37807-37808 -COMMA- denotes ,
T11797 37809-37811 NN denotes FP
T11798 37812-37813 -LRB- denotes (
T11799 37813-37816 CD denotes 500
T11800 37817-37819 NN denotes µg
T11801 37819-37820 -RRB- denotes )
T11802 37821-37830 VB denotes inhibited
T11803 37831-37834 NN denotes p38
T11804 37835-37839 NN denotes MAPK
T11805 37840-37855 NN denotes phosphorylation
T11806 37856-37858 IN denotes in
T11807 37859-37866 JJ denotes primary
T11808 37867-37868 NN denotes T
T11809 37869-37874 NN denotes cells
T11810 37875-37877 FW denotes in
T11811 37878-37882 FW denotes vivo
T11812 37883-37885 IN denotes at
T11813 37886-37887 CD denotes 2
T11814 37888-37889 NN denotes h
T11815 37890-37892 IN denotes in
T11816 37893-37900 NN denotes samples
T11817 37901-37905 IN denotes from
T11818 37906-37909 CD denotes two
T11819 37910-37918 NN denotes patients
T11820 37919-37920 -LRB- denotes (
T11821 37920-37926 NN denotes Figure
T11822 37927-37929 NN denotes 7E
T11823 37929-37930 -RRB- denotes )
T11824 39418-39423 VB denotes Taken
T11825 39424-39432 RB denotes together
T11826 39432-39433 -COMMA- denotes ,
T11827 39434-39437 PRP-DOLLAR- denotes our
T11828 39438-39442 NN denotes data
T11829 39443-39450 VB denotes suggest
T11830 39451-39455 IN denotes that
T11831 39456-39463 VB denotes inhaled
T11832 39464-39466 NN denotes FP
T11833 39467-39474 VB denotes reduces
T11834 39475-39482 JJ denotes nuclear
T11835 39483-39495 NN denotes localization
T11836 39496-39498 IN denotes of
T11837 39499-39505 NN denotes GATA-3
T11838 39506-39508 FW denotes in
T11839 39509-39513 FW denotes vivo
T11840 39514-39516 IN denotes by
T11841 39517-39524 RB denotes acutely
T11842 39525-39535 VB denotes inhibiting
T11843 39536-39559 NN denotes phospho-GATA-3–importin
T11844 39560-39571 NN denotes association
T11845 39573-39577 DT denotes This
T11846 39578-39584 NN denotes effect
T11847 39585-39588 MD denotes may
T11848 39589-39591 VB denotes be
T11849 39592-39598 JJ denotes direct
T11850 39598-39599 -COMMA- denotes ,
T11851 39600-39607 IN denotes through
T11852 39608-39619 NN denotes competition
T11853 39620-39623 IN denotes for
T11854 39624-39634 JJ denotes importin-α
T11855 39635-39637 CC denotes or
T11856 39638-39648 VB denotes associated
T11857 39649-39658 NN denotes molecules
T11858 39658-39659 -COMMA- denotes ,
T11859 39660-39662 CC denotes or
T11860 39663-39672 JJ denotes secondary
T11861 39673-39675 TO denotes to
T11862 39676-39678 DT denotes an
T11863 39679-39685 NN denotes effect
T11864 39686-39688 IN denotes on
T11865 39689-39692 NN denotes p38
T11866 39693-39706 JJ denotes MAPK-mediated
T11867 39707-39713 NN denotes GATA-3
T11868 39714-39729 NN denotes phosphorylation
T11869 39730-39733 IN denotes via
T11870 39734-39739 JJ denotes rapid
T11871 39740-39749 NN denotes induction
T11872 39750-39752 IN denotes of
T11873 39753-39758 NN denotes MKP-1
T11874 39760-39763 DT denotes The
T11875 39764-39775 NN denotes combination
T11876 39776-39778 IN denotes of
T11877 39779-39784 DT denotes these
T11878 39785-39788 CD denotes two
T11879 39789-39800 VB denotes interacting
T11880 39801-39808 NN denotes effects
T11881 39809-39812 MD denotes can
T11882 39813-39819 VB denotes result
T11883 39820-39822 IN denotes in
T11884 39823-39831 JJ denotes complete
T11885 39832-39843 NN denotes suppression
T11886 39844-39846 IN denotes of
T11887 39847-39853 NN denotes GATA-3
T11888 39854-39861 JJ denotes nuclear
T11889 39862-39868 NN denotes import
T11890 39869-39872 CC denotes and
T11891 39873-39877 RB denotes thus
T11892 39878-39881 NN denotes Th2
T11893 39882-39890 NN denotes cytokine
T11894 39891-39895 NN denotes gene
T11895 39896-39906 NN denotes expression
T13351 39920-39924 RB denotes Here
T13352 39925-39927 PRP denotes we
T13353 39928-39932 VB denotes have
T13354 39933-39945 VB denotes demonstrated
T13355 39945-39946 -COMMA- denotes ,
T13356 39947-39949 TO denotes to
T13357 39950-39953 PRP-DOLLAR- denotes our
T13358 39954-39963 NN denotes knowledge
T13359 39964-39967 IN denotes for
T13360 39968-39971 DT denotes the
T13361 39972-39977 JJ denotes first
T13362 39978-39982 NN denotes time
T13363 39982-39983 -COMMA- denotes ,
T13364 39984-39988 IN denotes that
T13365 39989-40004 NN denotes corticosteroids
T13366 40005-40008 MD denotes may
T13367 40009-40016 VB denotes inhibit
T13368 40017-40023 NN denotes GATA-3
T13369 40024-40032 NN denotes function
T13370 40033-40036 CC denotes and
T13371 40037-40046 RB denotes therefore
T13372 40047-40050 DT denotes the
T13373 40051-40064 NN denotes transcription
T13374 40065-40067 IN denotes of
T13375 40068-40071 NN denotes Th2
T13376 40072-40077 NN denotes genes
T13377 40078-40081 IN denotes via
T13378 40082-40085 CD denotes two
T13379 40086-40094 JJ denotes distinct
T13380 40095-40098 CC denotes but
T13381 40099-40110 VB denotes interacting
T13382 40111-40120 JJ denotes molecular
T13383 40121-40131 NN denotes mechanisms
T13384 40133-40140 RB denotes Firstly
T13385 40140-40141 -COMMA- denotes ,
T13386 40142-40166 JJ denotes corticosteroid-activated
T13387 40167-40169 NN denotes GR
T13388 40170-40177 VB denotes appears
T13389 40178-40180 TO denotes to
T13390 40181-40188 VB denotes compete
T13391 40189-40193 IN denotes with
T13392 40194-40203 VB denotes activated
T13393 40204-40210 NN denotes GATA-3
T13394 40211-40214 IN denotes for
T13395 40215-40222 JJ denotes nuclear
T13396 40223-40229 NN denotes import
T13397 40230-40233 IN denotes via
T13398 40234-40244 NN denotes importin-α
T13399 40244-40245 -COMMA- denotes ,
T13400 40246-40251 WDT denotes which
T13401 40252-40254 VB denotes is
T13402 40255-40263 VB denotes required
T13403 40264-40267 IN denotes for
T13404 40268-40271 DT denotes the
T13405 40272-40279 JJ denotes nuclear
T13406 40280-40289 NN denotes transport
T13407 40290-40292 IN denotes of
T13408 40293-40297 CC denotes both
T13409 40298-40304 NN denotes GATA-3
T13410 40305-40308 CC denotes and
T13411 40309-40311 NN denotes GR
T13412 40313-40321 RB denotes Secondly
T13413 40321-40322 -COMMA- denotes ,
T13414 40323-40338 NN denotes corticosteroids
T13415 40339-40341 IN denotes at
T13416 40342-40348 JJ denotes higher
T13417 40349-40363 NN denotes concentrations
T13418 40364-40372 VB denotes increase
T13419 40373-40376 DT denotes the
T13420 40377-40387 NN denotes expression
T13421 40388-40390 IN denotes of
T13422 40391-40396 NN denotes MKP-1
T13423 40396-40397 -COMMA- denotes ,
T13424 40398-40399 DT denotes a
T13425 40400-40406 JJ denotes potent
T13426 40407-40416 NN denotes inhibitor
T13427 40417-40419 IN denotes of
T13428 40420-40423 NN denotes p38
T13429 40424-40428 NN denotes MAPK
T13430 40429-40437 NN denotes activity
T13431 40438-40441 CC denotes and
T13432 40442-40449 RB denotes thereby
T13433 40450-40457 VB denotes prevent
T13434 40458-40459 NN denotes T
T13435 40460-40464 NN denotes cell
T13436 40465-40485 NN denotes receptor/co-receptor
T13437 40486-40496 NN denotes activation
T13438 40497-40499 IN denotes of
T13439 40500-40503 NN denotes p38
T13440 40504-40508 NN denotes MAPK
T13441 40509-40511 TO denotes to
T13442 40512-40519 VB denotes prevent
T13443 40520-40523 DT denotes the
T13444 40524-40539 NN denotes phosphorylation
T13445 40540-40542 IN denotes of
T13446 40543-40549 NN denotes GATA-3
T13447 40550-40554 WDT denotes that
T13448 40555-40557 VB denotes is
T13449 40558-40567 JJ denotes necessary
T13450 40568-40571 IN denotes for
T13451 40572-40583 NN denotes interaction
T13452 40584-40588 IN denotes with
T13453 40589-40599 JJ denotes importin-α
T13454 40600-40603 CC denotes and
T13455 40604-40614 JJ denotes subsequent
T13456 40615-40622 JJ denotes nuclear
T13457 40623-40629 NN denotes import
T13458 40631-40633 PRP denotes We
T13459 40634-40638 VB denotes have
T13460 40639-40649 RB denotes previously
T13461 40650-40655 VB denotes shown
T13462 40656-40660 IN denotes that
T13463 40661-40674 NN denotes translocation
T13464 40675-40677 IN denotes of
T13465 40678-40684 NN denotes GATA-3
T13466 40685-40689 IN denotes from
T13467 40690-40693 DT denotes the
T13468 40694-40703 NN denotes cytoplasm
T13469 40704-40706 TO denotes to
T13470 40707-40710 DT denotes the
T13471 40711-40718 NN denotes nucleus
T13472 40719-40727 VB denotes involves
T13473 40728-40731 DT denotes the
T13474 40732-40739 JJ denotes nuclear
T13475 40740-40751 NN denotes transporter
T13476 40752-40759 NN denotes protein
T13477 40760-40770 NN denotes importin-α
T13478 40770-40771 -COMMA- denotes ,
T13479 40772-40777 WDT denotes which
T13480 40778-40787 VB denotes interacts
T13481 40788-40792 IN denotes with
T13482 40793-40807 VB denotes phosphorylated
T13483 40808-40814 NN denotes GATA-3
T13484 40815-40816 -LRB- denotes [
T13485 40816-40818 CD denotes 12
T13486 40818-40819 -RRB- denotes ]
T13487 40821-40823 PRP denotes We
T13488 40824-40828 VB denotes have
T13489 40829-40833 RB denotes also
T13490 40834-40844 RB denotes previously
T13491 40845-40853 VB denotes reported
T13492 40854-40858 IN denotes that
T13493 40859-40865 NN denotes GATA-3
T13494 40866-40875 NN denotes knockdown
T13495 40876-40881 VB denotes using
T13496 40882-40887 NN denotes siRNA
T13497 40888-40895 VB denotes results
T13498 40896-40898 IN denotes in
T13499 40899-40910 NN denotes suppression
T13500 40911-40913 IN denotes of
T13501 40914-40938 JJ denotes anti-CD3/CD28–stimulated
T13502 40939-40948 NN denotes IL-4/IL-5
T13503 40949-40953 NN denotes mRNA
T13504 40954-40963 NN denotes induction
T13505 40963-40964 -COMMA- denotes ,
T13506 40965-40969 RB denotes thus
T13507 40970-40981 VB denotes implicating
T13508 40982-40984 DT denotes an
T13509 40985-40994 JJ denotes essential
T13510 40995-40999 NN denotes role
T13511 41000-41003 IN denotes for
T13512 41004-41010 NN denotes GATA-3
T13513 41011-41013 IN denotes in
T13514 41014-41017 DT denotes the
T13515 41018-41031 NN denotes transcription
T13516 41032-41034 IN denotes of
T13517 41035-41040 DT denotes these
T13518 41041-41046 NN denotes genes
T13519 41047-41048 -LRB- denotes [
T13520 41048-41050 CD denotes 12
T13521 41050-41051 -RRB- denotes ]
T13522 41053-41055 PRP denotes We
T13523 41056-41059 RB denotes now
T13524 41060-41067 VB denotes confirm
T13525 41067-41068 -COMMA- denotes ,
T13526 41069-41071 IN denotes in
T13527 41072-41077 JJ denotes human
T13528 41078-41079 NN denotes T
T13529 41080-41085 NN denotes cells
T13530 41085-41086 -COMMA- denotes ,
T13531 41087-41091 IN denotes that
T13532 41092-41094 NN denotes GR
T13533 41095-41099 RB denotes also
T13534 41100-41104 VB denotes uses
T13535 41105-41108 DT denotes the
T13536 41109-41113 JJ denotes same
T13537 41114-41121 JJ denotes nuclear
T13538 41122-41128 NN denotes import
T13539 41129-41138 NN denotes mechanism
T13540 41139-41141 IN denotes as
T13541 41142-41148 NN denotes GATA-3
T13542 41149-41150 -LRB- denotes [
T13543 41150-41152 CD denotes 22
T13544 41152-41153 -RRB- denotes ]
T13545 41155-41157 PRP denotes We
T13546 41158-41167 RB denotes therefore
T13547 41168-41175 VB denotes propose
T13548 41176-41180 IN denotes that
T13549 41181-41186 EX denotes there
T13550 41187-41189 VB denotes is
T13551 41190-41201 NN denotes competition
T13552 41202-41209 IN denotes between
T13553 41210-41226 JJ denotes ligand-activated
T13554 41227-41229 NN denotes GR
T13555 41230-41233 CC denotes and
T13556 41234-41248 NN denotes phospho-GATA-3
T13557 41249-41252 IN denotes for
T13558 41253-41260 JJ denotes nuclear
T13559 41261-41267 NN denotes import
T13560 41269-41280 RB denotes Furthermore
T13561 41280-41281 -COMMA- denotes ,
T13562 41282-41284 PRP denotes we
T13563 41285-41289 VB denotes have
T13564 41290-41295 VB denotes shown
T13565 41296-41300 IN denotes that
T13566 41301-41306 EX denotes there
T13567 41307-41309 VB denotes is
T13568 41310-41322 JJ denotes preferential
T13569 41323-41330 NN denotes binding
T13570 41331-41333 IN denotes of
T13571 41334-41344 NN denotes importin-α
T13572 41345-41347 TO denotes to
T13573 41348-41357 VB denotes activated
T13574 41358-41360 NN denotes GR
T13575 41361-41365 IN denotes over
T13576 41366-41380 NN denotes phospho-GATA-3
T13577 41380-41381 -COMMA- denotes ,
T13578 41382-41384 IN denotes so
T13579 41385-41389 IN denotes that
T13580 41390-41405 NN denotes corticosteroids
T13581 41406-41411 MD denotes would
T13582 41412-41426 RB denotes preferentially
T13583 41427-41433 VB denotes reduce
T13584 41434-41440 NN denotes GATA-3
T13585 41441-41446 NN denotes entry
T13586 41447-41450 CC denotes and
T13587 41451-41455 RB denotes thus
T13588 41456-41463 RB denotes rapidly
T13589 41464-41470 VB denotes switch
T13590 41471-41474 RP denotes off
T13591 41475-41478 NN denotes Th2
T13592 41479-41483 NN denotes gene
T13593 41484-41497 NN denotes transcription
T13594 41498-41505 IN denotes without
T13595 41506-41509 DT denotes any
T13596 41510-41514 NN denotes need
T13597 41515-41518 IN denotes for
T13598 41519-41522 DT denotes any
T13599 41523-41535 JJ denotes intermediate
T13600 41536-41541 NN denotes steps
T13601 41543-41554 RB denotes Furthermore
T13602 41554-41555 -COMMA- denotes ,
T13603 41556-41561 EX denotes there
T13604 41562-41565 VB denotes was
T13605 41566-41570 DT denotes some
T13606 41571-41577 NN denotes degree
T13607 41578-41580 IN denotes of
T13608 41581-41592 NN denotes specificity
T13609 41593-41596 IN denotes for
T13610 41597-41603 NN denotes GATA-3
T13611 41603-41604 -COMMA- denotes ,
T13612 41605-41607 IN denotes as
T13613 41608-41615 JJ denotes nuclear
T13614 41616-41629 NN denotes translocation
T13615 41630-41632 IN denotes of
T13616 41633-41636 DT denotes the
T13617 41637-41640 NN denotes p65
T13618 41641-41648 NN denotes subunit
T13619 41649-41651 IN denotes of
T13620 41652-41657 NN denotes NF-κB
T13621 41658-41661 VB denotes was
T13622 41662-41665 RB denotes not
T13623 41666-41674 VB denotes affected
T13624 41675-41677 IN denotes by
T13625 41678-41692 NN denotes corticosteroid
T13626 41693-41701 NN denotes exposure
T13627 41703-41705 PRP denotes We
T13628 41706-41712 VB denotes tested
T13629 41713-41717 DT denotes some
T13630 41718-41729 JJ denotes alternative
T13631 41730-41742 NN denotes explanations
T13632 41743-41746 IN denotes for
T13633 41747-41751 DT denotes this
T13634 41752-41758 NN denotes effect
T13635 41759-41761 IN denotes of
T13636 41762-41764 NN denotes FP
T13637 41765-41767 IN denotes on
T13638 41768-41774 NN denotes GATA-3
T13639 41775-41782 JJ denotes nuclear
T13640 41783-41792 NN denotes exclusion
T13641 41793-41796 CC denotes and
T13642 41797-41803 VB denotes failed
T13643 41804-41806 TO denotes to
T13644 41807-41811 VB denotes show
T13645 41812-41816 IN denotes that
T13646 41817-41819 NN denotes FP
T13647 41820-41826 CC denotes either
T13648 41827-41835 VB denotes enhances
T13649 41836-41842 NN denotes GATA-3
T13650 41843-41850 JJ denotes nuclear
T13651 41851-41857 NN denotes export
T13652 41858-41866 RB denotes directly
T13653 41867-41869 CC denotes or
T13654 41870-41877 VB denotes induces
T13655 41878-41884 NN denotes GATA-3
T13656 41885-41896 NN denotes degradation
T13657 41898-41901 DT denotes The
T13658 41902-41910 NN denotes evidence
T13659 41911-41915 IN denotes from
T13660 41916-41919 DT denotes the
T13661 41920-41922 FW denotes in
T13662 41923-41928 FW denotes vitro
T13663 41929-41940 NN denotes competition
T13664 41941-41947 NN denotes assays
T13665 41948-41952 VB denotes does
T13666 41952-41953 -COMMA- denotes ,
T13667 41954-41961 RB denotes however
T13668 41961-41962 -COMMA- denotes ,
T13669 41963-41970 VB denotes suggest
T13670 41971-41975 IN denotes that
T13671 41976-41984 VB denotes purified
T13672 41985-41994 VB denotes activated
T13673 41995-41997 NN denotes GR
T13674 41998-42001 MD denotes can
T13675 42002-42009 RB denotes clearly
T13676 42010-42019 VB denotes attenuate
T13677 42020-42028 VB denotes purified
T13678 42029-42054 NN denotes phospho-GATA-3–importin-α
T13679 42055-42066 NN denotes association
T13680 42067-42070 CC denotes and
T13681 42071-42075 IN denotes that
T13682 42076-42079 DT denotes the
T13683 42080-42088 NN denotes converse
T13684 42089-42093 VB denotes does
T13685 42094-42097 RB denotes not
T13686 42098-42103 VB denotes occur
T13687 42105-42116 RB denotes Furthermore
T13688 42116-42117 -COMMA- denotes ,
T13689 42118-42120 PRP denotes we
T13690 42121-42125 VB denotes have
T13691 42126-42131 VB denotes shown
T13692 42132-42136 IN denotes that
T13693 42137-42141 RB denotes only
T13694 42142-42156 NN denotes phospho-GATA-3
T13695 42157-42160 MD denotes can
T13696 42161-42170 VB denotes associate
T13697 42171-42175 IN denotes with
T13698 42176-42186 NN denotes importin-α
T13699 42188-42192 DT denotes This
T13700 42193-42202 NN denotes mechanism
T13701 42203-42205 VB denotes is
T13702 42206-42215 JJ denotes sensitive
T13703 42216-42218 TO denotes to
T13704 42219-42223 RB denotes very
T13705 42224-42227 JJ denotes low
T13706 42228-42242 NN denotes concentrations
T13707 42243-42245 IN denotes of
T13708 42246-42260 NN denotes corticosteroid
T13709 42261-42264 CC denotes and
T13710 42265-42270 MD denotes would
T13711 42271-42273 VB denotes be
T13712 42274-42279 JJ denotes rapid
T13713 42280-42282 IN denotes in
T13714 42283-42288 NN denotes onset
T13715 42289-42291 IN denotes as
T13716 42292-42294 DT denotes no
T13717 42295-42302 NN denotes changes
T13718 42303-42305 IN denotes in
T13719 42306-42313 NN denotes protein
T13720 42314-42323 NN denotes synthesis
T13721 42324-42327 VB denotes are
T13722 42328-42336 VB denotes required
T13723 42338-42342 DT denotes This
T13724 42343-42348 JJ denotes acute
T13725 42349-42358 NN denotes mechanism
T13726 42359-42362 MD denotes may
T13727 42363-42367 RB denotes also
T13728 42368-42378 VB denotes contribute
T13729 42379-42381 TO denotes to
T13730 42382-42385 DT denotes the
T13731 42386-42395 NN denotes reduction
T13732 42396-42398 IN denotes in
T13733 42399-42405 NN denotes GATA-3
T13734 42406-42413 JJ denotes nuclear
T13735 42414-42420 NN denotes import
T13736 42421-42424 CC denotes and
T13737 42425-42428 MD denotes may
T13738 42429-42433 VB denotes play
T13739 42434-42435 DT denotes a
T13740 42436-42441 JJ denotes major
T13741 42442-42446 NN denotes role
T13742 42447-42449 IN denotes at
T13743 42450-42453 JJ denotes low
T13744 42454-42468 NN denotes corticosteroid
T13745 42469-42483 NN denotes concentrations
T13746 42484-42490 CC denotes and/or
T13747 42491-42493 IN denotes at
T13748 42494-42499 JJ denotes early
T13749 42500-42504 NN denotes time
T13750 42505-42511 NN denotes points
T13751 42512-42517 RB denotes prior
T13752 42518-42520 TO denotes to
T13753 42521-42526 NN denotes MKP-1
T13754 42527-42536 NN denotes induction
T13755 42538-42553 NN denotes Corticosteroids
T13756 42554-42557 MD denotes can
T13757 42558-42566 VB denotes modulate
T13758 42567-42570 NN denotes p38
T13759 42571-42575 NN denotes MAPK
T13760 42576-42584 NN denotes activity
T13761 42585-42592 IN denotes through
T13762 42593-42596 DT denotes the
T13763 42597-42606 NN denotes induction
T13764 42607-42609 IN denotes of
T13765 42610-42615 NN denotes MKP-1
T13766 42615-42616 -COMMA- denotes ,
T13767 42617-42618 DT denotes a
T13768 42619-42625 JJ denotes potent
T13769 42626-42636 JJ denotes endogenous
T13770 42637-42646 NN denotes inhibitor
T13771 42647-42649 IN denotes of
T13772 42650-42654 NN denotes MAPK
T13773 42655-42663 NN denotes function
T13774 42664-42665 -LRB- denotes [
T13775 42665-42667 CD denotes 38
T13776 42667-42668 -RRB- denotes ]
T13777 42668-42669 -COMMA- denotes ,
T13778 42669-42670 -LRB- denotes [
T13779 42670-42672 CD denotes 39
T13780 42672-42673 -RRB- denotes ]
T13781 42675-42677 PRP denotes We
T13782 42678-42684 VB denotes report
T13783 42685-42689 RB denotes here
T13784 42690-42691 DT denotes a
T13785 42692-42697 JJ denotes rapid
T13786 42698-42707 NN denotes induction
T13787 42708-42710 IN denotes of
T13788 42711-42716 NN denotes MKP-1
T13789 42717-42721 NN denotes mRNA
T13790 42722-42731 VB denotes following
T13791 42732-42743 NN denotes stimulation
T13792 42744-42746 IN denotes of
T13793 42747-42752 NN denotes cells
T13794 42753-42757 IN denotes with
T13795 42758-42768 RB denotes relatively
T13796 42769-42773 JJ denotes high
T13797 42774-42788 NN denotes concentrations
T13798 42789-42791 IN denotes of
T13799 42792-42794 NN denotes FP
T13800 42796-42798 PRP denotes We
T13801 42799-42810 VB denotes hypothesize
T13802 42811-42815 IN denotes that
T13803 42816-42820 DT denotes this
T13804 42821-42826 JJ denotes rapid
T13805 42827-42836 NN denotes induction
T13806 42837-42839 IN denotes of
T13807 42840-42845 NN denotes MKP-1
T13808 42846-42849 MD denotes can
T13809 42850-42856 VB denotes reduce
T13810 42857-42863 NN denotes GATA-3
T13811 42864-42871 JJ denotes nuclear
T13812 42872-42878 NN denotes import
T13813 42879-42881 IN denotes by
T13814 42882-42893 VB denotes attenuating
T13815 42894-42897 NN denotes p38
T13816 42898-42902 NN denotes MAPK
T13817 42903-42911 NN denotes activity
T13818 42912-42915 CC denotes and
T13819 42916-42926 JJ denotes subsequent
T13820 42927-42933 NN denotes GATA-3
T13821 42934-42949 NN denotes phosphorylation
T13822 42949-42950 -COMMA- denotes ,
T13823 42951-42955 RB denotes thus
T13824 42956-42966 VB denotes preventing
T13825 42967-42974 JJ denotes nuclear
T13826 42975-42988 NN denotes translocation
T13827 42990-42993 DT denotes The
T13828 42994-43002 NN denotes location
T13829 43003-43005 IN denotes of
T13830 43006-43009 DT denotes the
T13831 43010-43016 NN denotes serine
T13832 43017-43024 NN denotes residue
T13833 43024-43025 -LRB- denotes (
T13834 43025-43026 NN denotes s
T13835 43026-43027 -RRB- denotes )
T13836 43028-43030 IN denotes of
T13837 43031-43037 NN denotes GATA-3
T13838 43038-43042 WDT denotes that
T13839 43043-43046 VB denotes are
T13840 43047-43061 VB denotes phosphorylated
T13841 43062-43064 IN denotes by
T13842 43065-43068 NN denotes p38
T13843 43069-43073 NN denotes MAPK
T13844 43074-43077 VB denotes are
T13845 43078-43087 RB denotes currently
T13846 43088-43095 JJ denotes unknown
T13847 43095-43096 -COMMA- denotes ,
T13848 43097-43100 CC denotes but
T13849 43101-43102 DT denotes a
T13850 43103-43117 NN denotes bioinformatics
T13851 43118-43124 NN denotes search
T13852 43125-43126 -LRB- denotes (
T13853 43126-43131 NNP denotes Motif
T13854 43132-43139 NNP denotes Scanner
T13855 43139-43140 -COMMA- denotes ,
T13856 43141-43145 NN denotes http
T13857 43145-43146 -COLON- denotes :
T13858 43146-43184 LS denotes //scansite.mit.edu/motifscan_seq.phtml
T13859 43184-43185 -RRB- denotes )
T13860 43186-43195 VB denotes indicates
T13861 43196-43198 IN denotes at
T13862 43199-43204 JJ denotes least
T13863 43205-43210 CD denotes three
T13864 43211-43220 JJ denotes potential
T13865 43221-43224 NN denotes p38
T13866 43225-43239 JJ denotes MAPK-sensitive
T13867 43240-43246 NN denotes serine
T13868 43247-43255 NN denotes residues
T13869 43257-43259 IN denotes As
T13870 43260-43269 VB denotes predicted
T13871 43270-43274 IN denotes from
T13872 43275-43280 DT denotes these
T13873 43281-43283 FW denotes in
T13874 43284-43289 FW denotes vitro
T13875 43290-43294 NN denotes data
T13876 43294-43295 -COMMA- denotes ,
T13877 43296-43306 NN denotes impairment
T13878 43307-43309 IN denotes of
T13879 43310-43316 NN denotes GATA-3
T13880 43317-43324 JJ denotes nuclear
T13881 43325-43331 NN denotes import
T13882 43332-43334 IN denotes by
T13883 43335-43337 NN denotes FP
T13884 43338-43341 MD denotes may
T13885 43341-43342 -COMMA- denotes ,
T13886 43343-43345 IN denotes at
T13887 43346-43351 JJ denotes least
T13888 43352-43354 IN denotes in
T13889 43355-43359 NN denotes part
T13890 43359-43360 -COMMA- denotes ,
T13891 43361-43369 VB denotes underlie
T13892 43370-43373 DT denotes the
T13893 43374-43382 NN denotes efficacy
T13894 43383-43385 IN denotes of
T13895 43386-43401 NN denotes corticosteroids
T13896 43402-43404 IN denotes in
T13897 43405-43416 VB denotes suppressing
T13898 43417-43425 JJ denotes allergic
T13899 43426-43438 NN denotes inflammation
T13900 43440-43448 IN denotes Although
T13901 43449-43451 PRP denotes we
T13902 43452-43455 VB denotes did
T13903 43456-43459 RB denotes not
T13904 43460-43466 VB denotes assess
T13905 43467-43470 DT denotes the
T13906 43471-43476 JJ denotes acute
T13907 43477-43487 JJ denotes inhibitory
T13908 43488-43494 NN denotes effect
T13909 43495-43497 IN denotes of
T13910 43498-43500 NN denotes FP
T13911 43501-43503 IN denotes on
T13912 43504-43507 DT denotes the
T13913 43508-43518 NN denotes expression
T13914 43519-43521 IN denotes of
T13915 43522-43526 NN denotes IL-4
T13916 43527-43531 NN denotes mRNA
T13917 43532-43534 FW denotes in
T13918 43535-43539 FW denotes vivo
T13919 43539-43540 -COMMA- denotes ,
T13920 43541-43542 DT denotes a
T13921 43543-43549 JJ denotes single
T13922 43550-43560 NN denotes inhalation
T13923 43561-43563 IN denotes of
T13924 43564-43566 NN denotes FP
T13925 43567-43568 -LRB- denotes (
T13926 43568-43571 CD denotes 500
T13927 43572-43574 NN denotes µg
T13928 43574-43575 -RRB- denotes )
T13929 43576-43579 MD denotes may
T13930 43580-43584 VB denotes have
T13931 43585-43595 JJ denotes comparable
T13932 43596-43603 NN denotes effects
T13933 43603-43604 -COMMA- denotes ,
T13934 43605-43607 IN denotes as
T13935 43608-43610 PRP denotes it
T13936 43611-43619 VB denotes provides
T13937 43620-43626 NN denotes plasma
T13938 43627-43633 NN denotes levels
T13939 43634-43640 IN denotes within
T13940 43641-43642 DT denotes a
T13941 43643-43651 JJ denotes relevant
T13942 43652-43657 NN denotes range
T13943 43658-43660 IN denotes of
T13944 43661-43675 NN denotes concentrations
T13945 43676-43680 VB denotes used
T13946 43681-43683 TO denotes to
T13947 43684-43692 VB denotes suppress
T13948 43693-43697 NN denotes IL-4
T13949 43698-43711 NN denotes transcription
T13950 43712-43714 IN denotes in
T13951 43715-43718 PRP-DOLLAR- denotes our
T13952 43719-43721 FW denotes in
T13953 43722-43727 FW denotes vitro
T13954 43728-43734 NN denotes system
T13955 43735-43736 -LRB- denotes [
T13956 43736-43738 CD denotes 37
T13957 43738-43739 -RRB- denotes ]
T13958 43741-43742 DT denotes A
T13959 43743-43748 JJ denotes lower
T13960 43749-43753 NN denotes dose
T13961 43754-43756 IN denotes of
T13962 43757-43764 VB denotes inhaled
T13963 43765-43767 NN denotes FP
T13964 43768-43769 -LRB- denotes (
T13965 43769-43772 CD denotes 100
T13966 43773-43775 NN denotes µg
T13967 43775-43776 -RRB- denotes )
T13968 43777-43780 VB denotes was
T13969 43781-43784 RB denotes not
T13970 43785-43794 JJ denotes effective
T13971 43794-43795 -COMMA- denotes ,
T13972 43796-43799 CC denotes but
T13973 43800-43806 NN denotes plasma
T13974 43807-43821 NN denotes concentrations
T13975 43822-43825 MD denotes may
T13976 43826-43828 VB denotes be
T13977 43829-43834 IN denotes below
T13978 43835-43840 DT denotes those
T13979 43841-43849 VB denotes required
T13980 43850-43853 IN denotes for
T13981 43854-43860 NN denotes GATA-3
T13982 43861-43871 NN denotes inhibition
T13983 43873-43880 RB denotes However
T13984 43880-43881 -COMMA- denotes ,
T13985 43882-43884 PRP denotes it
T13986 43885-43887 VB denotes is
T13987 43888-43894 JJ denotes likely
T13988 43895-43899 IN denotes that
T13989 43900-43903 DT denotes the
T13990 43904-43910 JJ denotes higher
T13991 43911-43925 NN denotes concentrations
T13992 43926-43928 IN denotes of
T13993 43929-43931 NN denotes FP
T13994 43932-43934 IN denotes in
T13995 43935-43938 DT denotes the
T13996 43939-43946 NN denotes airways
T13997 43947-43952 IN denotes after
T13998 43953-43960 VB denotes inhaled
T13999 43961-43975 NN denotes administration
T14000 43976-43981 MD denotes would
T14001 43982-43984 VB denotes be
T14002 43985-43994 JJ denotes effective
T14003 43995-43997 IN denotes in
T14004 43998-44008 VB denotes inhibiting
T14005 44009-44015 NN denotes GATA-3
T14006 44016-44018 IN denotes in
T14007 44019-44025 NN denotes airway
T14008 44026-44027 NN denotes T
T14009 44028-44033 NN denotes cells
T14010 44034-44036 IN denotes of
T14011 44037-44043 NN denotes asthma
T14012 44044-44052 NN denotes patients
T14013 44054-44057 DT denotes The
T14014 44058-44063 NN denotes study
T14015 44064-44066 IN denotes of
T14016 44067-44072 NN denotes PBMCs
T14017 44073-44077 IN denotes from
T14018 44078-44084 NN denotes asthma
T14019 44085-44093 NN denotes patients
T14020 44094-44101 VB denotes treated
T14021 44102-44106 IN denotes with
T14022 44107-44114 VB denotes inhaled
T14023 44115-44129 NN denotes corticosteroid
T14024 44130-44137 NN denotes therapy
T14025 44138-44145 RB denotes clearly
T14026 44146-44158 VB denotes demonstrates
T14027 44159-44163 IN denotes that
T14028 44164-44169 DT denotes these
T14029 44170-44179 JJ denotes molecular
T14030 44180-44190 NN denotes mechanisms
T14031 44191-44194 VB denotes are
T14032 44195-44201 JJ denotes likely
T14033 44202-44204 TO denotes to
T14034 44205-44209 RB denotes also
T14035 44210-44215 VB denotes occur
T14036 44216-44218 IN denotes in
T14037 44219-44227 NN denotes patients
T14038 44228-44230 IN denotes at
T14039 44231-44242 JJ denotes therapeutic
T14040 44243-44248 NN denotes doses
T14041 44249-44251 IN denotes of
T14042 44252-44259 VB denotes inhaled
T14043 44260-44275 NN denotes corticosteroids
T14044 44277-44279 IN denotes In
T14045 44280-44288 NN denotes addition
T14046 44288-44289 -COMMA- denotes ,
T14047 44290-44298 JJ denotes previous
T14048 44299-44306 NN denotes studies
T14049 44307-44311 VB denotes have
T14050 44312-44317 VB denotes shown
T14051 44318-44322 IN denotes that
T14052 44323-44338 NN denotes corticosteroids
T14053 44339-44342 MD denotes can
T14054 44343-44351 VB denotes suppress
T14055 44352-44356 NN denotes IL-4
T14056 44357-44360 CC denotes and
T14057 44361-44365 NN denotes IL-5
T14058 44366-44373 NN denotes release
T14059 44374-44378 IN denotes from
T14060 44379-44389 JJ denotes peripheral
T14061 44390-44395 NN denotes blood
T14062 44396-44401 NN denotes cells
T14063 44402-44404 IN denotes of
T14064 44405-44411 NN denotes asthma
T14065 44412-44420 NN denotes patients
T14066 44421-44423 FW denotes in
T14067 44424-44429 FW denotes vitro
T14068 44430-44433 CC denotes and
T14069 44434-44436 FW denotes in
T14070 44437-44441 FW denotes vivo
T14071 44442-44443 -LRB- denotes [
T14072 44443-44445 CD denotes 40
T14073 44445-44446 -RRB- denotes ]
T14074 44446-44447 CD denotes –
T14075 44447-44448 -LRB- denotes [
T14076 44448-44450 CD denotes 42
T14077 44450-44451 -RRB- denotes ]
T14078 44453-44455 IN denotes In
T14079 44456-44463 NN denotes summary
T14080 44463-44464 -COMMA- denotes ,
T14081 44465-44468 PRP-DOLLAR- denotes our
T14082 44469-44473 NN denotes data
T14083 44474-44481 VB denotes provide
T14084 44482-44490 NN denotes evidence
T14085 44491-44494 IN denotes for
T14086 44495-44496 DT denotes a
T14087 44497-44502 JJ denotes novel
T14088 44503-44509 NN denotes action
T14089 44510-44512 IN denotes of
T14090 44513-44528 NN denotes corticosteroids
T14091 44528-44529 -COLON- denotes :
T14092 44530-44541 NN denotes suppression
T14093 44542-44544 IN denotes of
T14094 44545-44553 JJ denotes allergic
T14095 44554-44566 NN denotes inflammation
T14096 44567-44574 IN denotes through
T14097 44575-44576 DT denotes a
T14098 44577-44582 JJ denotes rapid
T14099 44583-44593 JJ denotes inhibitory
T14100 44594-44600 NN denotes effect
T14101 44601-44603 IN denotes on
T14102 44604-44610 NN denotes GATA-3
T14103 44611-44618 JJ denotes nuclear
T14104 44619-44632 NN denotes translocation
T14105 44633-44635 IN denotes by
T14106 44636-44648 JJ denotes preferential
T14107 44649-44656 NN denotes binding
T14108 44657-44659 TO denotes to
T14109 44660-44663 DT denotes the
T14110 44664-44670 JJ denotes shared
T14111 44671-44678 JJ denotes nuclear
T14112 44679-44685 NN denotes import
T14113 44686-44693 NN denotes protein
T14114 44694-44704 NN denotes importin-α
T14115 44705-44708 CC denotes and
T14116 44709-44711 IN denotes by
T14117 44712-44713 DT denotes a
T14118 44714-44720 JJ denotes second
T14119 44721-44730 NN denotes mechanism
T14120 44731-44740 VB denotes involving
T14121 44741-44750 VB denotes increased
T14122 44751-44760 NN denotes synthesis
T14123 44761-44763 IN denotes of
T14124 44764-44769 NN denotes MKP-1
T14125 44769-44770 -COMMA- denotes ,
T14126 44771-44776 WDT denotes which
T14127 44777-44785 VB denotes inhibits
T14128 44786-44789 NN denotes p38
T14129 44790-44794 NN denotes MAPK
T14130 44794-44795 -COMMA- denotes ,
T14131 44796-44800 RB denotes thus
T14132 44801-44811 VB denotes preventing
T14133 44812-44815 DT denotes the
T14134 44816-44831 NN denotes phosphorylation
T14135 44832-44834 IN denotes of
T14136 44835-44841 NN denotes GATA-3
T14137 44842-44846 WDT denotes that
T14138 44847-44849 VB denotes is
T14139 44850-44859 JJ denotes necessary
T14140 44860-44863 IN denotes for
T14141 44864-44871 JJ denotes nuclear
T14142 44872-44885 NN denotes translocation
T14143 44886-44888 IN denotes of
T14144 44889-44895 NN denotes GATA-3
T14145 44897-44902 DT denotes These
T14146 44903-44906 CD denotes two
T14147 44907-44917 NN denotes mechanisms
T14148 44918-44921 VB denotes are
T14149 44922-44928 JJ denotes likely
T14150 44929-44931 TO denotes to
T14151 44932-44934 VB denotes be
T14152 44935-44946 JJ denotes synergistic
T14153 44946-44947 -COMMA- denotes ,
T14154 44948-44958 VB denotes accounting
T14155 44959-44962 IN denotes for
T14156 44963-44966 DT denotes the
T14157 44967-44972 JJ denotes rapid
T14158 44973-44976 CC denotes and
T14159 44977-44983 JJ denotes potent
T14160 44984-44990 NN denotes effect
T14161 44991-44993 IN denotes of
T14162 44994-45009 NN denotes corticosteroids
T14163 45010-45012 IN denotes on
T14164 45013-45021 JJ denotes allergic
T14165 45022-45034 NN denotes inflammation
T14166 45036-45040 DT denotes This
T14167 45041-45043 VB denotes is
T14168 45044-45055 VB denotes exemplified
T14169 45056-45058 IN denotes by
T14170 45059-45062 DT denotes the
T14171 45063-45068 JJ denotes rapid
T14172 45069-45079 JJ denotes inhibitory
T14173 45080-45086 NN denotes effect
T14174 45087-45089 IN denotes of
T14175 45090-45097 JJ denotes topical
T14176 45098-45113 NN denotes corticosteroids
T14177 45114-45116 IN denotes on
T14178 45117-45122 JJ denotes nasal
T14179 45123-45126 NN denotes Th2
T14180 45127-45135 NN denotes cytokine
T14181 45136-45143 NN denotes release
T14182 45144-45149 IN denotes after
T14183 45150-45158 NN denotes allergen
T14184 45159-45170 NN denotes provocation
T14185 45171-45173 IN denotes in
T14186 45174-45185 NN denotes individuals
T14187 45186-45190 IN denotes with
T14188 45191-45199 JJ denotes seasonal
T14189 45200-45208 JJ denotes allergic
T14190 45209-45217 NN denotes rhinitis
T14191 45218-45219 -LRB- denotes (
T14192 45219-45222 NN denotes hay
T14193 45223-45228 NN denotes fever
T14194 45228-45229 -RRB- denotes )
T14195 45230-45231 -LRB- denotes [
T14196 45231-45233 CD denotes 43
T14197 45233-45234 -RRB- denotes ]
T14198 45236-45246 NN denotes Prevention
T14199 45247-45249 IN denotes of
T14200 45250-45264 NN denotes phospho-GATA-3
T14201 45265-45276 NN denotes interaction
T14202 45277-45281 IN denotes with
T14203 45282-45292 NN denotes importin-α
T14204 45293-45296 MD denotes may
T14205 45297-45304 VB denotes provide
T14206 45305-45306 DT denotes a
T14207 45307-45310 JJ denotes new
T14208 45311-45319 NN denotes approach
T14209 45320-45323 IN denotes for
T14210 45324-45327 DT denotes the
T14211 45328-45339 NN denotes development
T14212 45340-45342 IN denotes of
T14213 45343-45348 JJ denotes novel
T14214 45349-45358 NN denotes therapies
T14215 45359-45362 IN denotes for
T14216 45363-45366 DT denotes the
T14217 45367-45376 NN denotes treatment
T14218 45377-45379 IN denotes of
T14219 45380-45388 JJ denotes allergic
T14220 45389-45397 NN denotes diseases
T16038 24319-24330 NN denotes Fluticasone
T16039 24331-24341 NN denotes propionate
T16040 24342-24356 VB denotes down-regulates
T16041 24357-24360 NN denotes Th2
T16042 24361-24369 NN denotes cytokine
T16043 24370-24374 NN denotes gene
T16044 24375-24385 NN denotes expression
T16045 24386-24389 CC denotes and
T16046 24390-24398 VB denotes inhibits
T16047 24399-24405 NN denotes GATA-3
T16048 24406-24413 JJ denotes nuclear
T16049 24414-24420 NN denotes import
T16050 24422-24423 -LRB- denotes (
T16051 24423-24424 NN denotes A
T16052 24424-24425 -RRB- denotes )
T16053 24426-24439 JJ denotes Anti-CD3/CD28
T16054 24440-24449 NN denotes treatment
T16055 24450-24452 IN denotes of
T16056 24453-24459 NN denotes HuT-78
T16057 24460-24465 NN denotes cells
T16058 24466-24473 VB denotes results
T16059 24474-24476 IN denotes in
T16060 24477-24490 NN denotes translocation
T16061 24491-24493 IN denotes of
T16062 24494-24500 NN denotes GATA-3
T16063 24501-24505 IN denotes from
T16064 24506-24509 DT denotes the
T16065 24510-24519 NN denotes cytoplasm
T16066 24520-24522 TO denotes to
T16067 24523-24526 DT denotes the
T16068 24527-24534 NN denotes nucleus
T16069 24535-24541 IN denotes within
T16070 24542-24544 CD denotes 30
T16071 24545-24549 NN denotes min.
T16072 24550-24551 -LRB- denotes (
T16073 24551-24552 NN denotes B
T16074 24552-24553 -RRB- denotes )
T16075 24554-24561 NN denotes Histone
T16076 24562-24564 NN denotes H1
T16077 24565-24568 CC denotes and
T16078 24569-24574 NN denotes MEK-1
T16079 24575-24579 VB denotes were
T16080 24580-24584 VB denotes used
T16081 24585-24587 TO denotes to
T16082 24588-24595 VB denotes confirm
T16083 24596-24604 JJ denotes distinct
T16084 24605-24615 NN denotes separation
T16085 24616-24618 IN denotes of
T16086 24619-24630 JJ denotes cytoplasmic
T16087 24631-24634 CC denotes and
T16088 24635-24642 JJ denotes nuclear
T16089 24643-24651 NN denotes extracts
T16090 24652-24654 IN denotes in
T16091 24655-24660 CD denotes three
T16092 24661-24669 JJ denotes separate
T16093 24670-24682 NN denotes experiments.
T16094 24683-24684 -LRB- denotes (
T16095 24684-24685 NN denotes C
T16096 24685-24686 -RRB- denotes )
T16097 24687-24694 JJ denotes Western
T16098 24695-24699 NN denotes blot
T16099 24700-24708 NN denotes analysis
T16100 24709-24711 IN denotes of
T16101 24712-24722 JJ denotes FP-treated
T16102 24723-24729 NN denotes HuT-78
T16103 24730-24735 NN denotes cells
T16104 24736-24748 VB denotes demonstrated
T16105 24749-24757 JJ denotes impaired
T16106 24758-24765 JJ denotes nuclear
T16107 24766-24778 NN denotes localization
T16108 24779-24781 IN denotes of
T16109 24782-24788 NN denotes GATA-3
T16110 24789-24796 VB denotes induced
T16111 24797-24799 IN denotes by
T16112 24800-24813 JJ denotes anti-CD3/CD28
T16113 24814-24828 NN denotes co-stimulation
T16114 24829-24831 IN denotes in
T16115 24832-24833 DT denotes a
T16116 24834-24839 NN denotes time-
T16117 24840-24841 -LRB- denotes (
T16118 24841-24843 IN denotes at
T16119 24844-24848 CD denotes 10−8
T16120 24849-24850 NN denotes M
T16121 24851-24853 NN denotes FP
T16122 24853-24854 -RRB- denotes )
T16123 24855-24858 CC denotes and
T16124 24859-24873 NN denotes concentration-
T16125 24874-24875 -LRB- denotes (
T16126 24875-24877 IN denotes at
T16127 24878-24880 CD denotes 60
T16128 24881-24884 NN denotes min
T16129 24885-24890 IN denotes after
T16130 24891-24902 NN denotes stimulation
T16131 24902-24903 -RRB- denotes )
T16132 24904-24913 JJ denotes dependent
T16133 24914-24920 NN denotes manner
T16134 24922-24927 NN denotes Cells
T16135 24928-24932 VB denotes were
T16136 24933-24943 VB denotes pretreated
T16137 24944-24948 IN denotes with
T16138 24949-24951 NN denotes FP
T16139 24952-24955 IN denotes for
T16140 24956-24958 CD denotes 30
T16141 24959-24962 NN denotes min
T16142 24963-24968 JJ denotes prior
T16143 24969-24971 TO denotes to
T16144 24972-24983 NN denotes stimulation
T16145 24985-24989 NN denotes MEK1
T16146 24990-24993 CC denotes and
T16147 24994-25001 NN denotes histone
T16148 25002-25004 NN denotes H1
T16149 25005-25009 VB denotes were
T16150 25010-25014 VB denotes used
T16151 25015-25017 TO denotes to
T16152 25018-25029 VB denotes demonstrate
T16153 25030-25035 JJ denotes equal
T16154 25036-25047 JJ denotes cytoplasmic
T16155 25048-25051 CC denotes and
T16156 25052-25059 JJ denotes nuclear
T16157 25060-25067 NN denotes loading
T16158 25068-25080 RB denotes respectively
T16159 25082-25089 NN denotes Results
T16160 25090-25093 VB denotes are
T16161 25094-25103 VB denotes presented
T16162 25104-25115 RB denotes graphically
T16163 25116-25121 IN denotes below
T16164 25122-25124 IN denotes as
T16165 25125-25133 NN denotes mean±SEM
T16166 25134-25136 IN denotes of
T16167 25137-25139 IN denotes at
T16168 25140-25145 JJ denotes least
T16169 25146-25151 CD denotes three
T16170 25152-25163 JJ denotes independent
T16171 25164-25176 NN denotes experiments.
T16172 25177-25180 SYM denotes ***
T16173 25181-25182 NN denotes p
T16174 25182-25183 SYM denotes <
T16175 25183-25188 CD denotes 0.001
T16176 25189-25197 VB denotes compared
T16177 25198-25200 TO denotes to
T16178 25201-25207 NN denotes t = 0.
T16179 25208-25209 -LRB- denotes (
T16180 25209-25210 NN denotes D
T16181 25210-25211 -RRB- denotes )
T16182 25212-25218 NN denotes RT-PCR
T16183 25219-25226 VB denotes showing
T16184 25227-25231 IN denotes that
T16185 25232-25234 NN denotes FP
T16186 25235-25243 VB denotes inhibits
T16187 25244-25248 NN denotes IL-4
T16188 25249-25252 CC denotes and
T16189 25253-25257 NN denotes IL-5
T16190 25258-25262 NN denotes mRNA
T16191 25263-25273 NN denotes expression
T16192 25274-25276 IN denotes in
T16193 25277-25298 JJ denotes CD3/CD28-costimulated
T16194 25299-25304 NN denotes cells
T16195 25306-25311 NN denotes GAPDH
T16196 25312-25315 VB denotes was
T16197 25316-25320 VB denotes used
T16198 25321-25323 IN denotes as
T16199 25324-25325 DT denotes a
T16200 25326-25333 NN denotes loading
T16201 25334-25341 NN denotes control
T16202 25343-25348 JJ denotes Lower
T16203 25349-25355 NN denotes panels
T16204 25356-25360 VB denotes show
T16205 25361-25370 JJ denotes graphical
T16206 25371-25379 NN denotes analysis
T16207 25380-25382 IN denotes of
T16208 25383-25390 NN denotes results
T16209 25391-25400 VB denotes presented
T16210 25401-25403 IN denotes as
T16211 25404-25412 NN denotes mean±SEM
T16212 25413-25415 IN denotes of
T16213 25416-25418 IN denotes at
T16214 25419-25424 JJ denotes least
T16215 25425-25430 CD denotes three
T16216 25431-25442 JJ denotes independent
T16217 25443-25455 NN denotes experiments.
T16218 25456-25457 -SHARP- denotes #
T16219 25457-25458 -SHARP- denotes #
T16220 25458-25459 -SHARP- denotes #
T16221 25181-25182 NN denotes p
T16222 25182-25183 SYM denotes <
T16223 25183-25188 CD denotes 0.001
T16224 25189-25197 VB denotes compared
T16225 25198-25200 TO denotes to
T16226 25480-25487 NN denotes control
T16227 25487-25488 -COMMA- denotes ,
T16228 25489-25493 NN denotes ***p
T16229 25493-25494 SYM denotes <
T16230 25494-25499 CD denotes 0.001
T16231 25500-25508 VB denotes compared
T16232 25509-25511 TO denotes to
T16233 25512-25537 JJ denotes anti-CD3/CD28–stimulated.
T16234 25538-25539 -LRB- denotes (
T16235 25539-25540 NN denotes E
T16236 25540-25541 -RRB- denotes )
T16237 25542-25544 NN denotes FP
T16238 25545-25546 -LRB- denotes (
T16239 25546-25548 CD denotes 10
T16240 25549-25551 NN denotes nM
T16241 25551-25552 -RRB- denotes )
T16242 25553-25560 VB denotes reduces
T16243 25561-25564 DT denotes the
T16244 25565-25572 NN denotes ability
T16245 25573-25575 IN denotes of
T16246 25576-25600 JJ denotes anti-CD3/CD28-stimulated
T16247 25601-25607 NN denotes GATA-3
T16248 25608-25610 TO denotes to
T16249 25611-25620 VB denotes associate
T16250 25621-25625 IN denotes with
T16251 25626-25629 DT denotes the
T16252 25630-25636 JJ denotes native
T16253 25637-25641 NN denotes IL-5
T16254 25642-25650 NN denotes promoter
T16255 25651-25653 CD denotes 60
T16256 25654-25657 NN denotes min
T16257 25658-25663 IN denotes after
T16258 25664-25675 NN denotes stimulation
T16259 25677-25681 NN denotes Data
T16260 25682-25685 VB denotes are
T16261 25686-25690 RB denotes also
T16262 25691-25696 VB denotes shown
T16263 25697-25708 RB denotes graphically
T16264 25709-25711 IN denotes as
T16265 25712-25720 NN denotes mean±SEM
T16266 25721-25723 IN denotes of
T16267 25724-25729 CD denotes three
T16268 25730-25741 JJ denotes independent
T16269 25742-25753 NN denotes experiments
T16270 25755-25758 DT denotes All
T16271 25759-25763 NN denotes data
T16272 25764-25768 VB denotes were
T16273 25769-25777 VB denotes analysed
T16274 25778-25780 IN denotes by
T16275 25781-25786 NN denotes ANOVA
T16276 25787-25795 VB denotes followed
T16277 25796-25798 IN denotes by
T16278 25799-25811 NN denotes Newman-Keuls
T16279 25812-25821 JJ denotes post-test
T16826 26735-26746 NN denotes Fluticasone
T16827 26747-26757 NN denotes propionate
T16828 26758-26765 VB denotes reduces
T16829 26766-26772 NN denotes GATA-3
T16830 26773-26784 NN denotes association
T16831 26785-26789 IN denotes with
T16832 26790-26800 NN denotes importin-α
T16833 26801-26804 CC denotes and
T16834 26805-26811 NN denotes GATA-3
T16835 26812-26819 JJ denotes nuclear
T16836 26820-26826 NN denotes import
T16837 26828-26829 -LRB- denotes (
T16838 26829-26830 NN denotes A
T16839 26830-26831 -RRB- denotes )
T16840 26832-26839 JJ denotes Western
T16841 26840-26844 NN denotes blot
T16842 26845-26853 NN denotes analysis
T16843 26854-26866 VB denotes demonstrates
T16844 26867-26868 DT denotes a
T16845 26869-26874 NN denotes time-
T16846 26875-26876 -LRB- denotes (
T16847 26876-26878 IN denotes at
T16848 26879-26883 CD denotes 10−8
T16849 26884-26885 NN denotes M
T16850 26886-26888 NN denotes FP
T16851 26888-26889 -RRB- denotes )
T16852 26890-26893 CC denotes and
T16853 26894-26908 NN denotes concentration-
T16854 26909-26910 -LRB- denotes (
T16855 26910-26912 IN denotes at
T16856 26913-26915 CD denotes 60
T16857 26916-26919 NN denotes min
T16858 26920-26925 IN denotes after
T16859 26926-26937 NN denotes stimulation
T16860 26937-26938 -RRB- denotes )
T16861 26939-26948 JJ denotes dependent
T16862 26949-26958 NN denotes induction
T16863 26959-26961 IN denotes of
T16864 26962-26974 JJ denotes FP-activated
T16865 26975-26977 NN denotes GR
T16866 26978-26989 NN denotes interaction
T16867 26990-26994 IN denotes with
T16868 26995-27005 NN denotes importin-α
T16869 27006-27007 -LRB- denotes (
T16870 27007-27012 NN denotes Imp-α
T16871 27012-27013 -RRB- denotes )
T16872 27015-27016 DT denotes A
T16873 27017-27025 JJ denotes positive
T16874 27026-27033 NN denotes control
T16875 27034-27037 IN denotes for
T16876 27038-27040 NN denotes GR
T16877 27041-27052 NN denotes association
T16878 27053-27057 IN denotes with
T16879 27058-27066 NN denotes importin
T16880 27067-27069 VB denotes is
T16881 27070-27075 VB denotes shown
T16882 27077-27091 NN denotes Quantification
T16883 27092-27094 IN denotes of
T16884 27095-27098 DT denotes the
T16885 27099-27111 NN denotes densitometry
T16886 27112-27116 NN denotes data
T16887 27117-27119 VB denotes is
T16888 27120-27125 VB denotes shown
T16889 27126-27131 IN denotes below
T16890 27133-27137 DT denotes Each
T16891 27138-27141 NN denotes bar
T16892 27142-27152 VB denotes represents
T16893 27153-27161 NN denotes mean±SEM
T16894 27162-27164 IN denotes of
T16895 27165-27167 IN denotes at
T16896 27168-27173 JJ denotes least
T16897 27174-27179 CD denotes three
T16898 27180-27191 JJ denotes independent
T16899 27192-27204 NN denotes experiments.
T16900 27205-27208 SYM denotes ***
T16901 27209-27210 NN denotes p
T16902 27210-27211 SYM denotes <
T16903 27211-27216 CD denotes 0.001
T16904 27217-27225 VB denotes compared
T16905 27226-27228 TO denotes to
T16906 27229-27236 NN denotes control
T16907 27236-27237 -COMMA- denotes ,
T16908 27238-27239 -SHARP- denotes #
T16909 27239-27240 -SHARP- denotes #
T16910 27240-27241 -SHARP- denotes #
T16911 27242-27243 NN denotes p
T16912 27243-27244 SYM denotes <
T16913 27244-27250 CD denotes 0.001.
T16914 27251-27252 -LRB- denotes (
T16915 27252-27253 NN denotes B
T16916 27253-27254 -RRB- denotes )
T16917 27255-27262 JJ denotes Western
T16918 27263-27267 NN denotes blot
T16919 27268-27276 NN denotes analysis
T16920 27277-27289 VB denotes demonstrated
T16921 27290-27291 DT denotes a
T16922 27292-27297 NN denotes time-
T16923 27298-27299 -LRB- denotes (
T16924 27299-27301 IN denotes at
T16925 27302-27306 CD denotes 10−8
T16926 27307-27308 NN denotes M
T16927 27309-27311 NN denotes FP
T16928 27311-27312 -RRB- denotes )
T16929 27313-27316 CC denotes and
T16930 27317-27331 NN denotes concentration-
T16931 27332-27333 -LRB- denotes (
T16932 27333-27335 IN denotes at
T16933 27336-27338 CD denotes 60
T16934 27339-27342 NN denotes min
T16935 27343-27348 IN denotes after
T16936 27349-27360 NN denotes stimulation
T16937 27360-27361 -RRB- denotes )
T16938 27362-27371 JJ denotes dependent
T16939 27372-27381 NN denotes induction
T16940 27382-27384 IN denotes of
T16941 27385-27397 JJ denotes FP-activated
T16942 27398-27400 NN denotes GR
T16943 27401-27408 JJ denotes nuclear
T16944 27409-27422 NN denotes translocation
T16945 27423-27431 VB denotes measured
T16946 27432-27434 IN denotes by
T16947 27435-27437 NN denotes IP
T16948 27439-27453 NN denotes Quantification
T16949 27454-27456 IN denotes of
T16950 27457-27460 DT denotes the
T16951 27461-27473 NN denotes densitometry
T16952 27474-27478 NN denotes data
T16953 27479-27481 VB denotes is
T16954 27482-27487 VB denotes shown
T16955 27488-27493 IN denotes below
T16956 27495-27499 DT denotes Each
T16957 27500-27503 NN denotes bar
T16958 27504-27514 VB denotes represents
T16959 27515-27523 NN denotes mean±SEM
T16960 27524-27526 IN denotes of
T16961 27527-27529 IN denotes at
T16962 27530-27535 JJ denotes least
T16963 27536-27541 CD denotes three
T16964 27542-27553 JJ denotes independent
T16965 27554-27566 NN denotes experiments.
T16966 27567-27571 NN denotes ***p
T16967 27571-27572 SYM denotes <
T16968 27572-27577 CD denotes 0.001
T16969 27578-27586 VB denotes compared
T16970 27587-27589 TO denotes to
T16971 27590-27598 NN denotes control.
T16972 27599-27600 -LRB- denotes (
T16973 27600-27601 NN denotes C
T16974 27601-27602 -RRB- denotes )
T16975 27603-27610 JJ denotes Western
T16976 27611-27615 NN denotes blot
T16977 27616-27624 NN denotes analysis
T16978 27625-27627 IN denotes of
T16979 27628-27634 NN denotes HuT-78
T16980 27635-27640 NN denotes cells
T16981 27641-27648 VB denotes treated
T16982 27649-27653 IN denotes with
T16983 27654-27656 NN denotes FP
T16984 27657-27660 CC denotes and
T16985 27661-27674 JJ denotes anti-CD3/CD28
T16986 27675-27689 NN denotes co-stimulation
T16987 27690-27702 VB denotes demonstrated
T16988 27703-27704 DT denotes a
T16989 27705-27728 JJ denotes concentration-dependent
T16990 27729-27737 NN denotes decrease
T16991 27738-27740 IN denotes in
T16992 27741-27758 NN denotes GATA-3–importin-α
T16993 27759-27770 NN denotes association
T16994 27771-27773 IN denotes at
T16995 27774-27776 CD denotes 20
T16996 27777-27780 NN denotes min
T16997 27782-27796 NN denotes Quantification
T16998 27797-27799 IN denotes of
T16999 27800-27803 DT denotes the
T17000 27804-27816 NN denotes densitometry
T17001 27817-27821 NN denotes data
T17002 27822-27824 VB denotes is
T17003 27825-27830 VB denotes shown
T17004 27831-27836 IN denotes below
T17005 27838-27842 DT denotes Each
T17006 27843-27846 NN denotes bar
T17007 27847-27857 VB denotes represents
T17008 27858-27866 NN denotes mean±SEM
T17009 27867-27869 IN denotes of
T17010 27870-27872 IN denotes at
T17011 27873-27878 JJ denotes least
T17012 27879-27884 CD denotes three
T17013 27885-27896 JJ denotes independent
T17014 27897-27909 NN denotes experiments.
T17015 27910-27911 -SHARP- denotes #
T17016 27911-27912 -SHARP- denotes #
T17017 27912-27913 -SHARP- denotes #
T17018 25181-25182 NN denotes p
T17019 25182-25183 SYM denotes <
T17020 25183-25188 CD denotes 0.001
T17021 25189-25197 VB denotes compared
T17022 25198-25200 TO denotes to
T17023 25480-25487 NN denotes control
T17024 25487-25488 -COMMA- denotes ,
T17025 25489-25493 NN denotes ***p
T17026 25493-25494 SYM denotes <
T17027 25494-25499 CD denotes 0.001
T17028 25500-25508 VB denotes compared
T17029 25509-25511 TO denotes to
T17030 27966-27986 JJ denotes αCD3/CD28-stimulated
T17031 27987-27993 NN denotes cells.
T17032 27994-27995 -LRB- denotes (
T17033 27995-27996 NN denotes D
T17034 27996-27997 -RRB- denotes )
T17035 27998-28008 JJ denotes GFP-tagged
T17036 28009-28015 NN denotes GATA-3
T17037 28016-28019 VB denotes was
T17038 28020-28033 VB denotes overexpressed
T17039 28034-28037 CC denotes and
T17040 28038-28043 NN denotes cells
T17041 28044-28054 VB denotes stimulated
T17042 28055-28056 -LRB- denotes (
T17043 28056-28057 NN denotes b
T17044 28057-28058 -COMMA- denotes ,
T17045 28059-28060 NN denotes c
T17046 28060-28061 -RRB- denotes )
T17047 28062-28064 CC denotes or
T17048 28065-28068 RB denotes not
T17049 28069-28070 -LRB- denotes (
T17050 28070-28071 DT denotes a
T17051 28071-28072 -RRB- denotes )
T17052 28073-28076 IN denotes for
T17053 28077-28079 CD denotes 30
T17054 28080-28083 NN denotes min
T17055 28084-28088 IN denotes with
T17056 28089-28102 NN denotes anti-CD3/CD28
T17057 28104-28107 DT denotes The
T17058 28108-28114 NN denotes effect
T17059 28115-28117 IN denotes of
T17060 28118-28120 CD denotes 30
T17061 28121-28124 NN denotes min
T17062 28125-28137 NN denotes pretreatment
T17063 28138-28140 IN denotes of
T17064 28141-28146 NN denotes cells
T17065 28147-28151 IN denotes with
T17066 28152-28154 NN denotes FP
T17067 28155-28156 -LRB- denotes (
T17068 28156-28160 CD denotes 10−8
T17069 28161-28162 NN denotes M
T17070 28162-28163 -COMMA- denotes ,
T17071 28164-28165 NN denotes c
T17072 28165-28166 -RRB- denotes )
T17073 28167-28169 VB denotes is
T17074 28170-28174 RB denotes also
T17075 28175-28180 VB denotes shown
T17076 28182-28185 DT denotes All
T17077 28186-28190 NN denotes data
T17078 28191-28195 VB denotes were
T17079 28196-28204 VB denotes analysed
T17080 28205-28207 IN denotes by
T17081 28208-28213 NN denotes ANOVA
T17082 28214-28222 VB denotes followed
T17083 28223-28225 IN denotes by
T17084 28226-28238 NN denotes Newman-Keuls
T17085 28239-28248 JJ denotes post-test
T17610 29403-29414 NN denotes Fluticasone
T17611 29415-29434 VB denotes propionate–mediated
T17612 29435-29445 NN denotes inhibition
T17613 29446-29448 IN denotes of
T17614 29449-29452 NN denotes p38
T17615 29453-29456 NN denotes MAP
T17616 29457-29463 NN denotes kinase
T17617 29464-29479 NN denotes phosphorylation
T17618 29480-29483 CC denotes and
T17619 29484-29494 NN denotes activation
T17620 29495-29497 VB denotes is
T17621 29498-29508 VB denotes associated
T17622 29509-29513 IN denotes with
T17623 29514-29515 DT denotes a
T17624 29516-29522 JJ denotes marked
T17625 29523-29538 NN denotes down-regulation
T17626 29539-29541 IN denotes of
T17627 29542-29548 NN denotes GATA-3
T17628 29549-29555 NN denotes serine
T17629 29556-29571 NN denotes phosphorylation
T17630 29573-29574 -LRB- denotes (
T17631 29574-29575 NN denotes A
T17632 29575-29576 -RRB- denotes )
T17633 29577-29584 JJ denotes Western
T17634 29585-29589 NN denotes blot
T17635 29590-29598 NN denotes analysis
T17636 29599-29604 VB denotes shows
T17637 29605-29609 IN denotes that
T17638 29610-29612 NN denotes FP
T17639 29613-29614 -LRB- denotes (
T17640 29614-29618 CD denotes 10−8
T17641 29619-29620 NN denotes M
T17642 29620-29621 -COMMA- denotes ,
T17643 29622-29624 CD denotes 30
T17644 29625-29628 NN denotes min
T17645 29628-29629 -RRB- denotes )
T17646 29630-29639 NN denotes treatment
T17647 29640-29647 VB denotes reduced
T17648 29648-29652 JJ denotes dual
T17649 29653-29668 NN denotes phosphorylation
T17650 29669-29670 -LRB- denotes (
T17651 29670-29683 CD denotes threonine-180
T17652 29684-29687 CC denotes and
T17653 29688-29700 NN denotes tyrosine-182
T17654 29700-29701 -RRB- denotes )
T17655 29702-29704 IN denotes of
T17656 29705-29708 NN denotes p38
T17657 29709-29713 NN denotes MAPK
T17658 29714-29716 IN denotes in
T17659 29717-29744 JJ denotes anti-CD3/CD28–co-stimulated
T17660 29745-29751 NN denotes HuT-78
T17661 29752-29758 NN denotes cells.
T17662 29759-29760 -LRB- denotes (
T17663 29760-29761 NN denotes B
T17664 29761-29762 -RRB- denotes )
T17665 29763-29767 NN denotes Time
T17666 29768-29774 NN denotes course
T17667 29775-29777 IN denotes of
T17668 29778-29781 DT denotes the
T17669 29782-29788 NN denotes effect
T17670 29789-29791 IN denotes of
T17671 29792-29794 NN denotes FP
T17672 29795-29796 -LRB- denotes (
T17673 29796-29800 CD denotes 10−8
T17674 29801-29802 NN denotes M
T17675 29802-29803 -RRB- denotes )
T17676 29804-29806 IN denotes on
T17677 29807-29822 NN denotes phosphorylation
T17678 29823-29825 IN denotes of
T17679 29826-29835 VB denotes activated
T17680 29836-29849 NN denotes transcription
T17681 29850-29856 NN denotes factor
T17682 29857-29858 CD denotes 2
T17683 29859-29860 -LRB- denotes (
T17684 29860-29865 NN denotes ATF-2
T17685 29865-29866 -RRB- denotes )
T17686 29866-29867 -COMMA- denotes ,
T17687 29868-29869 DT denotes a
T17688 29870-29877 NN denotes measure
T17689 29878-29880 IN denotes of
T17690 29881-29884 NN denotes p38
T17691 29885-29889 NN denotes MAPK
T17692 29890-29899 NN denotes activity.
T17693 29900-29901 -LRB- denotes (
T17694 29901-29902 NN denotes C
T17695 29902-29903 -RRB- denotes )
T17696 29904-29914 JJ denotes FP-induced
T17697 29915-29925 NN denotes inhibition
T17698 29926-29928 IN denotes of
T17699 29929-29932 NN denotes p38
T17700 29933-29937 NN denotes MAPK
T17701 29938-29946 NN denotes activity
T17702 29947-29949 VB denotes is
T17703 29950-29960 VB denotes associated
T17704 29961-29965 IN denotes with
T17705 29966-29969 DT denotes the
T17706 29970-29978 NN denotes decrease
T17707 29979-29981 IN denotes of
T17708 29982-29995 JJ denotes anti-CD3/CD28
T17709 29996-30018 JJ denotes co-stimulation–induced
T17710 30019-30025 NN denotes serine
T17711 30026-30041 NN denotes phosphorylation
T17712 30042-30043 -LRB- denotes (
T17713 30043-30048 NN denotes P-Ser
T17714 30048-30049 -RRB- denotes )
T17715 30050-30052 IN denotes of
T17716 30053-30059 NN denotes GATA-3
T17717 30061-30064 IN denotes For
T17718 30065-30066 -LRB- denotes (
T17719 30066-30069 NN denotes A–C
T17720 30069-30070 -RRB- denotes )
T17721 30070-30071 -COMMA- denotes ,
T17722 30072-30086 NN denotes quantification
T17723 30087-30089 IN denotes of
T17724 30090-30093 DT denotes the
T17725 30094-30106 NN denotes densitometry
T17726 30107-30111 NN denotes data
T17727 30112-30114 VB denotes is
T17728 30115-30119 RB denotes also
T17729 30120-30125 VB denotes shown
T17730 30127-30131 DT denotes Each
T17731 30132-30135 NN denotes bar
T17732 30136-30146 VB denotes represents
T17733 30147-30155 NN denotes mean±SEM
T17734 30156-30158 IN denotes of
T17735 30159-30161 IN denotes at
T17736 30162-30167 JJ denotes least
T17737 30168-30173 CD denotes three
T17738 30174-30185 JJ denotes independent
T17739 30186-30198 NN denotes experiments.
T17740 30199-30200 -SHARP- denotes #
T17741 30200-30201 -SHARP- denotes #
T17742 30201-30202 -SHARP- denotes #
T17743 25181-25182 NN denotes p
T17744 25182-25183 SYM denotes <
T17745 25183-25188 CD denotes 0.001
T17746 25189-25197 VB denotes compared
T17747 25198-25200 TO denotes to
T17748 25480-25487 NN denotes control
T17749 25487-25488 -COMMA- denotes ,
T17750 25489-25493 NN denotes ***p
T17751 25493-25494 SYM denotes <
T17752 25494-25499 CD denotes 0.001
T17753 25500-25508 VB denotes compared
T17754 25509-25511 TO denotes to
T17755 27966-27986 JJ denotes αCD3/CD28-stimulated
T17756 27987-27993 NN denotes cells.
T17757 27994-27995 -LRB- denotes (
T17758 27995-27996 NN denotes D
T17759 27996-27997 -RRB- denotes )
T17760 30287-30289 NN denotes FP
T17761 30290-30297 VB denotes induced
T17762 30298-30303 NN denotes MKP-1
T17763 30304-30308 NN denotes mRNA
T17764 30309-30311 IN denotes in
T17765 30312-30313 DT denotes a
T17766 30314-30337 JJ denotes concentration-dependent
T17767 30338-30344 NN denotes manner
T17768 30346-30349 DT denotes All
T17769 30350-30357 NN denotes results
T17770 30358-30361 VB denotes are
T17771 30362-30376 JJ denotes representative
T17772 30377-30379 IN denotes of
T17773 30380-30382 IN denotes at
T17774 30383-30388 JJ denotes least
T17775 30389-30394 CD denotes three
T17776 30395-30406 JJ denotes independent
T17777 30407-30418 NN denotes experiments
T17778 30419-30422 CC denotes and
T17779 30423-30428 WRB denotes where
T17780 30429-30440 JJ denotes appropriate
T17781 30441-30450 VB denotes expressed
T17782 30451-30453 IN denotes as
T17783 30454-30463 NN denotes means±SEM
T17784 30463-30464 -COMMA- denotes ,
T17785 30465-30467 NN denotes *p
T17786 30467-30468 SYM denotes <
T17787 30468-30473 CD denotes 0.05.
T17788 30474-30475 -LRB- denotes (
T17789 30475-30476 NN denotes E
T17790 30476-30477 -RRB- denotes )
T17791 30478-30480 NN denotes FP
T17792 30481-30488 VB denotes induces
T17793 30489-30494 NN denotes MKP-1
T17794 30495-30499 NN denotes mRNA
T17795 30500-30502 IN denotes in
T17796 30503-30504 DT denotes a
T17797 30505-30519 JJ denotes time-dependent
T17798 30520-30526 NN denotes manner
T17799 30528-30535 NN denotes Results
T17800 30536-30539 VB denotes are
T17801 30540-30554 JJ denotes representative
T17802 30555-30557 IN denotes of
T17803 30558-30561 CD denotes two
T17804 30562-30573 JJ denotes independent
T17805 30574-30585 NN denotes experiments
T17806 30587-30590 DT denotes All
T17807 30591-30595 NN denotes data
T17808 30596-30602 IN denotes except
T17809 30603-30604 -LRB- denotes (
T17810 30604-30605 NN denotes E
T17811 30605-30606 -RRB- denotes )
T17812 30607-30611 VB denotes were
T17813 30612-30620 VB denotes analysed
T17814 30621-30623 IN denotes by
T17815 30624-30629 NN denotes ANOVA
T17816 30630-30638 VB denotes followed
T17817 30639-30641 IN denotes by
T17818 30642-30654 NN denotes Newman-Keuls
T17819 30655-30664 JJ denotes post-test
T18718 33262-33273 NN denotes Fluticasone
T18719 33274-33284 NN denotes propionate
T18720 33285-33289 VB denotes does
T18721 33290-33293 RB denotes not
T18722 33294-33300 VB denotes affect
T18723 33301-33307 NN denotes GATA-3
T18724 33308-33315 JJ denotes nuclear
T18725 33316-33322 NN denotes export
T18726 33324-33325 -LRB- denotes (
T18727 33325-33326 NN denotes A
T18728 33326-33327 -RRB- denotes )
T18729 33328-33335 JJ denotes Western
T18730 33336-33340 NN denotes blot
T18731 33341-33349 NN denotes analysis
T18732 33350-33357 VB denotes showing
T18733 33358-33362 IN denotes that
T18734 33363-33366 DT denotes the
T18735 33367-33374 JJ denotes nuclear
T18736 33375-33381 NN denotes export
T18737 33382-33391 NN denotes inhibitor
T18738 33392-33402 NN denotes leptomycin
T18739 33403-33404 NN denotes B
T18740 33405-33406 -LRB- denotes (
T18741 33406-33407 CD denotes 2
T18742 33408-33410 NN denotes nM
T18743 33410-33411 -RRB- denotes )
T18744 33412-33416 VB denotes does
T18745 33417-33420 RB denotes not
T18746 33421-33427 VB denotes affect
T18747 33428-33431 DT denotes the
T18748 33432-33439 NN denotes ability
T18749 33440-33442 IN denotes of
T18750 33443-33445 NN denotes FP
T18751 33446-33447 -LRB- denotes (
T18752 33447-33451 CD denotes 10−8
T18753 33452-33453 NN denotes M
T18754 33453-33454 -RRB- denotes )
T18755 33455-33457 TO denotes to
T18756 33458-33465 VB denotes prevent
T18757 33466-33490 JJ denotes anti-CD3/CD28–stimulated
T18758 33491-33497 NN denotes GATA-3
T18759 33498-33505 JJ denotes nuclear
T18760 33506-33518 NN denotes localization
T18761 33519-33527 VB denotes measured
T18762 33528-33530 IN denotes at
T18763 33531-33533 CD denotes 60
T18764 33534-33538 NN denotes min.
T18765 33539-33543 NN denotes ***p
T18766 33543-33544 SYM denotes <
T18767 33544-33549 CD denotes 0.001
T18768 33550-33558 VB denotes compared
T18769 33559-33561 TO denotes to
T18770 33562-33574 JJ denotes unstimulated
T18771 33575-33580 NN denotes cells
T18772 33580-33581 -COMMA- denotes ,
T18773 33582-33583 -SHARP- denotes #
T18774 33583-33584 -SHARP- denotes #
T18775 33584-33585 -SHARP- denotes #
T18776 25492-25493 NN denotes p
T18777 25493-25494 SYM denotes <
T18778 25494-25499 CD denotes 0.001
T18779 25500-25508 VB denotes compared
T18780 25509-25511 TO denotes to
T18781 25512-25536 JJ denotes anti-CD3/CD28–stimulated
T18782 33631-33637 NN denotes cells.
T18783 33638-33639 -LRB- denotes (
T18784 33639-33640 NN denotes B
T18785 33640-33641 -RRB- denotes )
T18786 33642-33649 JJ denotes Western
T18787 33650-33654 NN denotes blot
T18788 33655-33663 NN denotes analysis
T18789 33664-33671 VB denotes showing
T18790 33672-33676 IN denotes that
T18791 33677-33679 NN denotes FP
T18792 33680-33681 -LRB- denotes (
T18793 33681-33685 CD denotes 10−8
T18794 33686-33687 NN denotes M
T18795 33687-33688 -RRB- denotes )
T18796 33689-33693 VB denotes does
T18797 33694-33697 RB denotes not
T18798 33698-33704 VB denotes affect
T18799 33705-33715 JJ denotes whole-cell
T18800 33716-33722 NN denotes GATA-3
T18801 33723-33734 NN denotes degradation
T18802 33735-33739 IN denotes over
T18803 33740-33742 CD denotes 17
T18804 33743-33745 NN denotes h.
T18805 33746-33747 -LRB- denotes (
T18806 33747-33748 NN denotes C
T18807 33748-33749 -RRB- denotes )
T18808 33750-33760 JJ denotes GFP-tagged
T18809 33761-33767 NN denotes GATA-3
T18810 33768-33770 VB denotes is
T18811 33771-33784 VB denotes overexpressed
T18812 33785-33788 CC denotes and
T18813 33789-33794 NN denotes cells
T18814 33795-33805 VB denotes stimulated
T18815 33806-33807 -LRB- denotes (
T18816 33807-33810 NN denotes b–j
T18817 33810-33811 -RRB- denotes )
T18818 33812-33814 CC denotes or
T18819 33815-33818 RB denotes not
T18820 33819-33820 -LRB- denotes (
T18821 33820-33821 DT denotes a
T18822 33821-33822 -RRB- denotes )
T18823 33823-33827 IN denotes with
T18824 33828-33841 NN denotes anti-CD3/CD28
T18825 33843-33846 DT denotes The
T18826 33847-33853 NN denotes effect
T18827 33854-33856 IN denotes of
T18828 33857-33865 VB denotes treating
T18829 33866-33871 NN denotes cells
T18830 33872-33876 IN denotes with
T18831 33877-33879 NN denotes FP
T18832 33880-33881 -LRB- denotes (
T18833 33881-33885 CD denotes 10−8
T18834 33886-33887 NN denotes M
T18835 33887-33888 -COMMA- denotes ,
T18836 33889-33892 NN denotes f–j
T18837 33892-33893 -RRB- denotes )
T18838 33894-33899 IN denotes after
T18839 33900-33902 CD denotes 30
T18840 33903-33906 NN denotes min
T18841 33907-33918 NN denotes stimulation
T18842 33919-33923 IN denotes with
T18843 33924-33937 NN denotes anti-CD3/CD28
T18844 33938-33940 VB denotes is
T18845 33941-33945 RB denotes also
T18846 33946-33952 NN denotes shown.
T18847 33953-33954 -LRB- denotes (
T18848 33954-33955 NN denotes D
T18849 33955-33956 -RRB- denotes )
T18850 33957-33959 NN denotes FP
T18851 33960-33961 -LRB- denotes (
T18852 33961-33965 CD denotes 10−8
T18853 33966-33967 NN denotes M
T18854 33967-33968 -RRB- denotes )
T18855 33969-33973 VB denotes does
T18856 33974-33977 RB denotes not
T18857 33978-33985 VB denotes prevent
T18858 33986-34010 JJ denotes anti-CD3/CD28–stimulated
T18859 34011-34014 NN denotes p65
T18860 34015-34022 JJ denotes nuclear
T18861 34023-34036 NN denotes translocation
T18862 34037-34039 IN denotes at
T18863 34040-34042 CD denotes 60
T18864 34043-34046 NN denotes min
T18865 34047-34052 IN denotes after
T18866 34053-34065 NN denotes stimulation.
T18867 34066-34069 NN denotes **p
T18868 34069-34070 SYM denotes <
T18869 34070-34074 CD denotes 0.01
T18870 34075-34083 VB denotes compared
T18871 34084-34086 TO denotes to
T18872 34087-34099 JJ denotes unstimulated
T18873 34100-34105 NN denotes cells
T18874 34107-34110 DT denotes All
T18875 34111-34118 NN denotes results
T18876 34119-34122 VB denotes are
T18877 34123-34137 JJ denotes representative
T18878 34138-34140 IN denotes of
T18879 34141-34143 IN denotes at
T18880 34144-34149 JJ denotes least
T18881 34150-34154 CD denotes four
T18882 34155-34166 JJ denotes independent
T18883 34167-34178 NN denotes experiments
T18884 34179-34182 CC denotes and
T18885 34183-34186 VB denotes are
T18886 34187-34192 VB denotes shown
T18887 34193-34195 IN denotes as
T18888 34196-34204 NN denotes mean±SEM
T18889 34206-34213 NN denotes Results
T18890 34214-34218 VB denotes were
T18891 34219-34227 VB denotes analysed
T18892 34228-34230 IN denotes by
T18893 34231-34236 NN denotes ANOVA
T18894 34237-34245 VB denotes followed
T18895 34246-34248 IN denotes by
T18896 34249-34261 JJ denotes Newman-Keuls
T18897 34262-34266 NN denotes test
T19291 34789-34800 NN denotes Fluticasone
T19292 34801-34811 NN denotes propionate
T19293 34812-34819 VB denotes impairs
T19294 34820-34826 NN denotes GATA-3
T19295 34827-34838 NN denotes interaction
T19296 34839-34843 IN denotes with
T19297 34844-34854 NN denotes importin-α
T19298 34855-34858 CC denotes and
T19299 34859-34865 NN denotes GATA-3
T19300 34866-34873 JJ denotes nuclear
T19301 34874-34886 NN denotes localization
T19302 34887-34889 FW denotes in
T19303 34890-34894 FW denotes vivo
T19304 34895-34898 CC denotes and
T19305 34899-34901 FW denotes ex
T19306 34902-34906 FW denotes vivo
T19307 34908-34909 -LRB- denotes (
T19308 34909-34910 NN denotes A
T19309 34911-34914 CC denotes and
T19310 34915-34916 NN denotes B
T19311 34916-34917 -RRB- denotes )
T19312 34918-34940 NN denotes Co-immunoprecipitation
T19313 34941-34949 NN denotes analysis
T19314 34950-34952 IN denotes of
T19315 34953-34958 NN denotes PBMCs
T19316 34959-34963 IN denotes from
T19317 34964-34977 JJ denotes steroid-naïve
T19318 34978-34984 NN denotes asthma
T19319 34985-34993 NN denotes patients
T19320 34994-35001 VB denotes treated
T19321 35002-35006 IN denotes with
T19322 35007-35009 NN denotes FP
T19323 35010-35012 FW denotes in
T19324 35013-35018 FW denotes vitro
T19325 35019-35031 VB denotes demonstrated
T19326 35032-35040 JJ denotes impaired
T19327 35041-35052 NN denotes interaction
T19328 35053-35060 IN denotes between
T19329 35061-35067 NN denotes GATA-3
T19330 35068-35071 CC denotes and
T19331 35072-35082 NN denotes importin-α
T19332 35083-35091 VB denotes measured
T19333 35092-35094 IN denotes at
T19334 35095-35097 CD denotes 60
T19335 35098-35101 NN denotes min
T19336 35103-35107 DT denotes Each
T19337 35108-35111 NN denotes bar
T19338 35112-35122 VB denotes represents
T19339 35123-35126 DT denotes the
T19340 35127-35135 NN denotes mean±SEM
T19341 35136-35138 IN denotes of
T19342 35139-35141 IN denotes at
T19343 35142-35147 JJ denotes least
T19344 35148-35153 CD denotes three
T19345 35154-35165 JJ denotes independent
T19346 35166-35177 NN denotes experiments
T19347 35177-35178 -COLON- denotes ;
T19348 35179-35182 SYM denotes ***
T19349 35183-35184 NN denotes p
T19350 35184-35185 SYM denotes <
T19351 35185-35190 CD denotes 0.001
T19352 35191-35199 VB denotes compared
T19353 35200-35204 IN denotes with
T19354 35205-35212 NN denotes control
T19355 35213-35215 IN denotes as
T19356 35216-35226 VB denotes determined
T19357 35227-35229 IN denotes by
T19358 35230-35248 JJ denotes ANOVA/Newman-Keuls
T19359 35249-35258 NN denotes analysis.
T19360 35259-35260 -LRB- denotes (
T19361 35260-35261 NN denotes C
T19362 35262-35265 CC denotes and
T19363 35266-35267 NN denotes D
T19364 35267-35268 -RRB- denotes )
T19365 35269-35291 NN denotes Co-immunoprecipitation
T19366 35292-35300 NN denotes analyses
T19367 35301-35303 IN denotes of
T19368 35304-35309 NN denotes PBMCs
T19369 35310-35314 IN denotes from
T19370 35315-35328 JJ denotes steroid-naïve
T19371 35329-35335 NN denotes asthma
T19372 35336-35344 NN denotes patients
T19373 35345-35352 VB denotes treated
T19374 35353-35357 IN denotes with
T19375 35358-35365 VB denotes inhaled
T19376 35366-35368 NN denotes FP
T19377 35369-35370 -LRB- denotes (
T19378 35370-35373 CD denotes 500
T19379 35374-35376 NN denotes µg
T19380 35377-35380 IN denotes via
T19381 35381-35382 DT denotes a
T19382 35383-35389 NN denotes spacer
T19383 35389-35390 -RRB- denotes )
T19384 35391-35393 FW denotes in
T19385 35394-35398 FW denotes vivo
T19386 35399-35411 VB denotes demonstrated
T19387 35412-35421 VB denotes decreased
T19388 35422-35433 NN denotes association
T19389 35434-35441 IN denotes between
T19390 35442-35448 NN denotes GATA-3
T19391 35449-35452 CC denotes and
T19392 35453-35463 NN denotes importin-α
T19393 35465-35468 DT denotes The
T19394 35469-35479 JJ denotes individual
T19395 35480-35486 NN denotes values
T19396 35487-35490 IN denotes for
T19397 35491-35495 DT denotes each
T19398 35496-35505 NN denotes treatment
T19399 35506-35509 VB denotes are
T19400 35510-35519 VB denotes presented
T19401 35520-35532 NN denotes graphically.
T19402 35533-35534 -LRB- denotes (
T19403 35534-35535 NN denotes E
T19404 35535-35536 -RRB- denotes )
T19405 35537-35551 JJ denotes Representative
T19406 35552-35559 JJ denotes Western
T19407 35560-35564 NN denotes blot
T19408 35565-35572 VB denotes showing
T19409 35573-35577 IN denotes that
T19410 35578-35588 JJ denotes importin-α
T19411 35589-35599 NN denotes expression
T19412 35600-35603 VB denotes was
T19413 35604-35614 JJ denotes unaffected
T19414 35615-35617 IN denotes by
T19415 35618-35628 NN denotes inhalation
T19416 35629-35631 IN denotes of
T19417 35632-35634 NN denotes FP
T19418 35636-35640 NN denotes Blot
T19419 35641-35643 VB denotes is
T19420 35644-35658 JJ denotes representative
T19421 35659-35661 IN denotes of
T19422 35662-35666 NN denotes gels
T19423 35667-35671 IN denotes from
T19424 35672-35677 CD denotes three
T19425 35678-35690 NN denotes participants
T19732 37976-37983 VB denotes Inhaled
T19733 37984-37995 NN denotes fluticasone
T19734 37996-38006 NN denotes propionate
T19735 38007-38014 VB denotes impairs
T19736 38015-38021 NN denotes GATA-3
T19737 38022-38029 JJ denotes nuclear
T19738 38030-38042 NN denotes localization
T19739 38043-38045 IN denotes in
T19740 38046-38051 NN denotes PBMCs
T19741 38053-38054 -LRB- denotes (
T19742 38054-38055 NN denotes A
T19743 38055-38056 -RRB- denotes )
T19744 38057-38071 JJ denotes Representative
T19745 38072-38091 NN denotes immunocytochemistry
T19746 38092-38094 IN denotes of
T19747 38095-38102 VB denotes showing
T19748 38103-38106 DT denotes the
T19749 38107-38113 NN denotes effect
T19750 38114-38116 IN denotes of
T19751 38117-38124 VB denotes inhaled
T19752 38125-38127 NN denotes FP
T19753 38128-38129 -LRB- denotes (
T19754 38129-38132 CD denotes 500
T19755 38133-38135 NN denotes µg
T19756 38135-38136 -RRB- denotes )
T19757 38137-38139 IN denotes on
T19758 38140-38142 NN denotes GR
T19759 38143-38146 CC denotes and
T19760 38147-38153 NN denotes GATA-3
T19761 38154-38161 JJ denotes nuclear
T19762 38162-38175 NN denotes localisation.
T19763 38176-38177 -LRB- denotes (
T19764 38177-38178 NN denotes B
T19765 38178-38179 -RRB- denotes )
T19766 38180-38187 JJ denotes Nuclear
T19767 38188-38194 NN denotes GATA-3
T19768 38195-38211 NN denotes immunoreactivity
T19769 38212-38214 IN denotes in
T19770 38215-38220 NN denotes PBMCs
T19771 38221-38225 IN denotes from
T19772 38226-38231 CD denotes seven
T19773 38232-38245 JJ denotes steroid-naïve
T19774 38246-38252 NN denotes asthma
T19775 38253-38261 NN denotes patients
T19776 38262-38263 CD denotes 2
T19777 38264-38265 NN denotes h
T19778 38266-38275 VB denotes following
T19779 38276-38283 VB denotes inhaled
T19780 38284-38286 NN denotes FP
T19781 38287-38296 NN denotes treatment
T19782 38297-38298 -LRB- denotes (
T19783 38298-38301 CD denotes 100
T19784 38302-38304 CC denotes or
T19785 38305-38308 CD denotes 500
T19786 38309-38311 NN denotes µg
T19787 38312-38315 IN denotes via
T19788 38316-38322 NN denotes spacer
T19789 38322-38323 -RRB- denotes )
T19790 38325-38328 DT denotes The
T19791 38329-38335 JJ denotes median
T19792 38336-38339 CC denotes and
T19793 38340-38353 JJ denotes interquartile
T19794 38354-38360 NN denotes ranges
T19795 38361-38364 IN denotes for
T19796 38365-38369 DT denotes each
T19797 38370-38379 NN denotes treatment
T19798 38380-38383 VB denotes are
T19799 38384-38393 VB denotes presented
T19800 38394-38396 IN denotes as
T19801 38397-38398 DT denotes a
T19802 38399-38415 NN denotes box-and-whiskers
T19803 38416-38420 NN denotes plot
T19804 38421-38422 -LRB- denotes (
T19805 38422-38427 NN denotes n = 7
T19806 38427-38428 -RRB- denotes )
T19807 38428-38429 -COLON- denotes ;
T19808 38430-38431 SYM denotes *
T19809 38432-38433 NN denotes p
T19810 38433-38434 SYM denotes <
T19811 38434-38438 CD denotes 0.05
T19812 38439-38447 NNP denotes Wilcoxon
T19813 38447-38449 POS denotes 's
T19814 38450-38454 NN denotes rank
T19815 38455-38459 NN denotes test
T19816 38460-38468 VB denotes compared
T19817 38469-38473 IN denotes with
T19818 38474-38482 NN denotes placebo.
T19819 38483-38484 -LRB- denotes (
T19820 38484-38485 NN denotes C
T19821 38485-38486 -RRB- denotes )
T19822 38487-38501 NN denotes Immunoblotting
T19823 38502-38510 NN denotes analyses
T19824 38511-38513 IN denotes of
T19825 38514-38519 NN denotes PBMCs
T19826 38520-38532 VB denotes demonstrated
T19827 38533-38534 DT denotes a
T19828 38535-38549 JJ denotes time-dependent
T19829 38550-38558 NN denotes decrease
T19830 38559-38561 IN denotes in
T19831 38562-38569 JJ denotes nuclear
T19832 38570-38580 NN denotes expression
T19833 38581-38583 IN denotes of
T19834 38584-38590 NN denotes GATA-3
T19835 38590-38591 -COMMA- denotes ,
T19836 38592-38595 CC denotes and
T19837 38596-38605 VB denotes increased
T19838 38606-38617 JJ denotes cytoplasmic
T19839 38618-38624 NN denotes GATA-3
T19840 38625-38635 NN denotes expression
T19841 38636-38641 IN denotes after
T19842 38642-38652 NN denotes inhalation
T19843 38653-38655 IN denotes of
T19844 38656-38659 NNP denotes FP.
T19845 38660-38661 -LRB- denotes (
T19846 38661-38662 NN denotes D
T19847 38662-38663 -RRB- denotes )
T19848 38664-38678 NN denotes Immunoblotting
T19849 38679-38687 NN denotes analyses
T19850 38688-38690 IN denotes of
T19851 38691-38696 NN denotes PBMCs
T19852 38697-38709 VB denotes demonstrated
T19853 38710-38711 DT denotes a
T19854 38712-38726 JJ denotes dose-dependent
T19855 38727-38735 NN denotes decrease
T19856 38736-38738 IN denotes in
T19857 38739-38746 JJ denotes nuclear
T19858 38747-38757 NN denotes expression
T19859 38758-38760 IN denotes of
T19860 38761-38767 NN denotes GATA-3
T19861 38767-38768 -COMMA- denotes ,
T19862 38769-38772 CC denotes and
T19863 38773-38782 VB denotes increased
T19864 38783-38794 JJ denotes cytoplasmic
T19865 38795-38801 NN denotes GATA-3
T19866 38802-38812 NN denotes expression
T19867 38813-38814 CD denotes 2
T19868 38815-38816 NN denotes h
T19869 38817-38822 IN denotes after
T19870 38823-38833 NN denotes inhalation
T19871 38834-38836 IN denotes of
T19872 38837-38839 NN denotes FP
T19873 38841-38848 NN denotes Histone
T19874 38849-38851 NN denotes H1
T19875 38852-38855 CC denotes and
T19876 38856-38861 NN denotes MEK-1
T19877 38862-38876 NN denotes immunoblotting
T19878 38877-38886 VB denotes confirmed
T19879 38887-38897 JJ denotes equivalent
T19880 38898-38903 JJ denotes total
T19881 38904-38911 NN denotes protein
T19882 38912-38919 VB denotes loading
T19883 38920-38923 IN denotes for
T19884 38924-38927 DT denotes the
T19885 38928-38935 JJ denotes nuclear
T19886 38936-38939 CC denotes and
T19887 38940-38951 JJ denotes cytoplasmic
T19888 38952-38961 NN denotes fractions
T19889 38962-38974 RB denotes respectively
T19890 38976-38990 NN denotes Quantification
T19891 38991-38993 IN denotes of
T19892 38994-38997 DT denotes the
T19893 38998-39010 NN denotes densitometry
T19894 39011-39015 NN denotes data
T19895 39016-39018 IN denotes in
T19896 39019-39020 -LRB- denotes (
T19897 39020-39021 NN denotes C
T19898 39021-39022 -RRB- denotes )
T19899 39023-39026 CC denotes and
T19900 39027-39028 -LRB- denotes (
T19901 39028-39029 NN denotes D
T19902 39029-39030 -RRB- denotes )
T19903 39031-39033 VB denotes is
T19904 39034-39039 VB denotes shown
T19905 39040-39042 IN denotes as
T19906 39043-39044 DT denotes a
T19907 39045-39061 JJ denotes box-and-whiskers
T19908 39062-39066 NN denotes plot
T19909 39067-39069 IN denotes of
T19910 39070-39077 NN denotes results
T19911 39078-39082 IN denotes from
T19912 39083-39088 NN denotes n = 6
T19913 39089-39101 NN denotes participants
T19914 39102-39105 IN denotes for
T19915 39106-39111 WDT denotes which
T19916 39112-39116 NN denotes data
T19917 39117-39121 VB denotes were
T19918 39122-39132 JJ denotes available.
T19919 39133-39135 NN denotes *p
T19920 39135-39136 SYM denotes <
T19921 39136-39140 CD denotes 0.05
T19922 39141-39149 VB denotes compared
T19923 39150-39152 TO denotes to
T19924 39153-39161 VB denotes control.
T19925 39162-39163 -LRB- denotes (
T19926 39163-39164 NN denotes E
T19927 39164-39165 -RRB- denotes )
T19928 39166-39173 JJ denotes Western
T19929 39174-39178 NN denotes blot
T19930 39179-39187 NN denotes analyses
T19931 39188-39190 IN denotes of
T19932 39191-39196 NN denotes PBMCs
T19933 39197-39209 VB denotes demonstrated
T19934 39210-39211 DT denotes a
T19935 39212-39226 JJ denotes time-dependent
T19936 39227-39235 NN denotes decrease
T19937 39236-39238 IN denotes in
T19938 39239-39243 JJ denotes dual
T19939 39244-39259 NN denotes phosphorylation
T19940 39260-39261 -LRB- denotes (
T19941 39261-39274 CD denotes threonine-180
T19942 39275-39278 CC denotes and
T19943 39279-39291 NN denotes tyrosine-182
T19944 39291-39292 -RRB- denotes )
T19945 39293-39295 IN denotes of
T19946 39296-39299 NN denotes p38
T19947 39300-39304 NN denotes MAPK
T19948 39305-39310 IN denotes after
T19949 39311-39321 NN denotes inhalation
T19950 39322-39324 IN denotes of
T19951 39325-39327 NN denotes FP
T19952 39328-39329 -LRB- denotes (
T19953 39329-39332 CD denotes 500
T19954 39333-39335 NN denotes µg
T19955 39335-39336 -RRB- denotes )
T19956 39338-39341 DT denotes The
T19957 39342-39349 NN denotes results
T19958 39350-39355 VB denotes shown
T19959 39356-39358 IN denotes in
T19960 39359-39360 -LRB- denotes (
T19961 39360-39361 NN denotes E
T19962 39361-39362 -RRB- denotes )
T19963 39363-39366 VB denotes are
T19964 39367-39381 JJ denotes representative
T19965 39382-39384 IN denotes of
T19966 39385-39392 NN denotes samples
T19967 39393-39397 IN denotes from
T19968 39398-39401 CD denotes two
T19969 39402-39414 NN denotes participants
T5299 16620-16622 CD denotes 35
T5300 16623-16629 NN denotes cycles
R99 T149 T150 arg1Of Suppression,of
R100 T149 T156 arg1Of Suppression,:
R101 T153 T151 arg1Of Import,GATA-3
R102 T153 T152 arg1Of Import,Nuclear
R103 T153 T154 arg1Of Import,and
R104 T154 T150 arg2Of and,of
R105 T155 T154 arg2Of Phosphorylation,and
R106 T159 T156 arg2Of Mechanism,:
R107 T159 T157 arg1Of Mechanism,A
R108 T159 T158 arg1Of Mechanism,Novel
R109 T159 T160 arg1Of Mechanism,of
R110 T162 T160 arg2Of Action,of
R111 T162 T161 arg1Of Action,Corticosteroid
R112 T162 T163 arg1Of Action,in
R113 T165 T163 arg2Of Disease,in
R114 T165 T164 arg1Of Disease,Allergic
R115 T167 T168 arg1Of GATA-3,plays
R116 T167 T173 arg1Of GATA-3,regulating
R117 T167 T198 arg1Of GATA-3,is
R118 T168 T172 arg1Of plays,in
R119 T168 T196 arg1Of plays,and
R120 T171 T168 arg2Of role,plays
R121 T171 T169 arg1Of role,a
R122 T171 T170 arg1Of role,critical
R123 T173 T172 arg2Of regulating,in
R124 T175 T173 arg2Of expression,regulating
R125 T175 T174 arg1Of expression,the
R126 T175 T176 arg1Of expression,of
R127 T175 T189 arg1Of expression,from
R128 T178 T177 arg1Of cytokines,the
R129 T179 T180 arg1Of interleukin,(
R130 T179 T183 arg1Of interleukin,-4
R131 T179 T184 arg1Of interleukin,","
R132 T181 T180 arg2Of IL,(
R133 T182 T180 arg3Of ),(
R134 T184 T187 arg1Of ",",and
R135 T185 T184 arg2Of IL-5,","
R136 T187 T176 arg2Of and,of
R137 T187 T178 arg1Of and,cytokines
R138 T187 T186 arg1Of and,","
R139 T188 T187 arg2Of IL-13,and
R140 T193 T192 arg2Of Th2,(
R141 T194 T192 arg3Of ),(
R142 T195 T189 arg2Of cells,from
R143 T195 T190 arg1Of cells,T
R144 T195 T191 arg1Of cells,helper-2
R145 T195 T192 arg1Of cells,(
R146 T198 T196 arg2Of is,and
R147 T198 T197 arg1Of is,therefore
R148 T201 T198 arg2Of mediator,is
R149 T201 T199 arg1Of mediator,a
R150 T201 T200 arg1Of mediator,key
R151 T201 T202 arg1Of mediator,of
R152 T204 T202 arg2Of diseases,of
R153 T204 T203 arg1Of diseases,allergic
R154 T205 T206 arg1Of Corticosteroids,are
R155 T205 T208 arg1Of Corticosteroids,effective
R156 T206 T214 arg1Of are,but
R157 T208 T206 arg2Of effective,are
R158 T208 T207 arg1Of effective,highly
R159 T208 T209 arg1Of effective,in
R160 T210 T209 arg2Of suppressing,in
R161 T212 T210 arg2Of inflammation,suppressing
R162 T212 T211 arg1Of inflammation,allergic
R163 T214 T213 arg1Of but,","
R164 T216 T215 arg1Of effects,their
R165 T216 T217 arg1Of effects,on
R166 T216 T219 arg1Of effects,are
R167 T216 T220 arg1Of effects,unknown
R168 T218 T217 arg2Of GATA-3,on
R169 T219 T214 arg2Of are,but
R170 T220 T219 arg2Of unknown,are
R171 T221 T222 arg1Of We,investigated
R172 T222 T237 arg1Of investigated,vitro
R173 T222 T240 arg1Of investigated,vivo
R174 T224 T222 arg2Of effect,investigated
R175 T224 T223 arg1Of effect,the
R176 T224 T225 arg1Of effect,of
R177 T224 T230 arg1Of effect,on
R178 T229 T225 arg2Of propionate,of
R179 T229 T226 arg1Of propionate,the
R180 T229 T227 arg1Of propionate,corticosteroid
R181 T229 T228 arg1Of propionate,fluticasone
R182 T232 T230 arg2Of regulation,on
R183 T232 T231 arg1Of regulation,GATA-3
R184 T232 T233 arg1Of regulation,in
R185 T235 T233 arg2Of T-lymphocytes,in
R186 T235 T234 arg1Of T-lymphocytes,human
R187 T237 T236 arg1Of vitro,in
R188 T237 T238 arg1Of vitro,and
R189 T240 T238 arg2Of vivo,and
R190 T240 T239 arg1Of vivo,in
R191 T241 T242 arg1Of Methods,and
R192 T243 T242 arg2Of Findings,and
R193 T249 T246 arg1Of line,T
R194 T249 T247 arg1Of line,lymphocyte
R195 T249 T248 arg1Of line,cell
R196 T249 T250 arg1Of line,(
R197 T249 T253 arg1Of line,and
R198 T251 T250 arg2Of HuT-78,(
R199 T252 T250 arg3Of ),(
R200 T253 T244 arg2Of and,In
R201 T253 T245 arg1Of and,a
R202 T253 T264 arg1Of and,vitro
R203 T257 T253 arg2Of cells,and
R204 T257 T254 arg1Of cells,peripheral
R205 T257 T255 arg1Of cells,blood
R206 T257 T256 arg1Of cells,mononuclear
R207 T257 T258 arg2Of cells,stimulated
R208 T260 T261 arg1Of anti-CD3,and
R209 T261 T258 arg1Of and,stimulated
R210 T261 T259 arg2Of and,by
R211 T262 T261 arg2Of anti-CD28,and
R212 T264 T263 arg1Of vitro,in
R213 T265 T266 arg1Of we,demonstrated
R214 T266 T244 arg1Of demonstrated,In
R215 T268 T269 arg1Of fluticasone,inhibits
R216 T268 T287 arg1Of fluticasone,is
R217 T268 T288 arg1Of fluticasone,due
R218 T269 T279 arg1Of inhibits,via
R219 T269 T286 arg1Of inhibits,and
R220 T271 T270 arg1Of translocation,nuclear
R221 T271 T272 arg1Of translocation,of
R222 T271 T274 arg1Of translocation,and
R223 T273 T272 arg2Of GATA-3,of
R224 T274 T269 arg2Of and,inhibits
R225 T275 T274 arg2Of expression,and
R226 T275 T276 arg1Of expression,of
R227 T278 T276 arg2Of cytokines,of
R228 T278 T277 arg1Of cytokines,Th2
R229 T281 T279 arg2Of mechanism,via
R230 T281 T280 arg1Of mechanism,a
R231 T281 T282 arg1Of mechanism,independent
R232 T282 T283 arg1Of independent,of
R233 T285 T283 arg2Of factor-κB,of
R234 T285 T284 arg1Of factor-κB,nuclear
R235 T286 T266 arg2Of and,demonstrated
R236 T286 T267 arg1Of and,that
R237 T287 T286 arg2Of is,and
R238 T287 T292 arg1Of is,","
R239 T287 T293 arg1Of is,to
R240 T288 T287 arg2Of due,is
R241 T288 T289 arg1Of due,","
R242 T288 T290 arg1Of due,in
R243 T291 T290 arg2Of part,in
R244 T294 T293 arg2Of competition,to
R245 T294 T295 arg1Of competition,between
R246 T296 T297 arg1Of GATA-3,and
R247 T297 T295 arg2Of and,between
R248 T301 T297 arg2Of receptor,and
R249 T301 T298 arg1Of receptor,the
R250 T301 T299 arg1Of receptor,ligand-activated
R251 T301 T300 arg1Of receptor,glucocorticoid
R252 T353 T348 arg2Of and,are
R253 T353 T352 arg1Of and,","
R254 T301 T302 arg1Of receptor,for
R255 T301 T305 arg1Of receptor,through
R256 T304 T302 arg2Of transport,for
R257 T354 T353 arg2Of prolonged,and
R258 T355 T357 arg1Of We,demonstrated
R259 T357 T356 arg1Of demonstrated,also
R260 T360 T359 arg2Of fluticasone,inhaled
R261 T360 T361 arg1Of fluticasone,inhibits
R262 T304 T303 arg1Of transport,nuclear
R263 T361 T357 arg2Of inhibits,demonstrated
R264 T361 T358 arg1Of inhibits,that
R265 T309 T305 arg2Of importin-α,through
R266 T364 T361 arg2Of translocation,inhibits
R267 T364 T362 arg1Of translocation,GATA-3
R268 T364 T363 arg1Of translocation,nuclear
R269 T364 T365 arg1Of translocation,in
R270 T368 T365 arg2Of lymphocytes,in
R271 T368 T366 arg1Of lymphocytes,peripheral
R272 T368 T367 arg1Of lymphocytes,blood
R273 T368 T369 arg1Of lymphocytes,of
R274 T370 T369 arg2Of patients,of
R275 T370 T371 arg1Of patients,with
R276 T309 T306 arg1Of importin-α,the
R277 T372 T371 arg2Of asthma,with
R278 T372 T374 arg1Of asthma,vivo
R279 T309 T307 arg1Of importin-α,nuclear
R280 T309 T308 arg1Of importin-α,importer
R281 T374 T373 arg1Of vivo,in
R282 T311 T310 arg2Of addition,In
R283 T376 T377 arg1Of Corticosteroids,have
R284 T377 T384 arg1Of have,via
R285 T313 T314 arg1Of fluticasone,induces
R286 T380 T379 arg1Of inhibitory,potent
R287 T381 T377 arg2Of effect,have
R288 T381 T378 arg1Of effect,a
R289 T381 T380 arg1Of effect,inhibitory
R290 T314 T310 arg1Of induces,In
R291 T381 T382 arg1Of effect,on
R292 T383 T382 arg2Of GATA-3,on
R293 T314 T312 arg1Of induces,","
R294 T316 T314 arg2Of expression,induces
R295 T387 T384 arg2Of mechanisms,via
R296 T387 T385 arg1Of mechanisms,two
R297 T387 T386 arg1Of mechanisms,interacting
R298 T387 T388 arg1Of mechanisms,that
R299 T387 T390 arg1Of mechanisms,suppress
R300 T390 T389 arg1Of suppress,potently
R301 T316 T315 arg1Of expression,the
R302 T316 T317 arg1Of expression,of
R303 T320 T318 arg1Of kinase,mitogen-activated
R304 T393 T390 arg2Of expression,suppress
R305 T393 T391 arg1Of expression,Th2
R306 T393 T392 arg1Of expression,cytokine
R307 T396 T394 arg1Of mechanism,This
R308 T396 T395 arg1Of mechanism,novel
R309 T396 T397 arg1Of mechanism,of
R310 T396 T401 arg1Of mechanism,may
R311 T396 T402 arg1Of mechanism,account
R312 T398 T397 arg2Of action,of
R313 T398 T399 arg1Of action,of
R314 T400 T399 arg2Of corticosteroids,of
R315 T402 T401 arg2Of account,may
R316 T402 T403 arg1Of account,for
R317 T320 T319 arg1Of kinase,protein
R318 T320 T321 arg1Of kinase,(
R319 T322 T321 arg2Of MAPK,(
R320 T407 T403 arg2Of efficacy,for
R321 T407 T404 arg1Of efficacy,the
R322 T407 T405 arg1Of efficacy,striking
R323 T407 T406 arg1Of efficacy,clinical
R324 T407 T408 arg1Of efficacy,of
R325 T407 T410 arg1Of efficacy,in
R326 T409 T408 arg2Of corticosteroids,of
R327 T323 T321 arg3Of ),(
R328 T412 T410 arg2Of treatment,in
R329 T412 T411 arg1Of treatment,the
R330 T412 T413 arg1Of treatment,of
R331 T324 T317 arg2Of phosphatase-1,of
R332 T415 T413 arg2Of diseases,of
R333 T415 T414 arg1Of diseases,allergic
R334 T417 T416 arg1Of see,Please
R335 T324 T320 arg1Of phosphatase-1,kinase
R336 T324 T325 arg1Of phosphatase-1,(
R337 T324 T328 arg1Of phosphatase-1,","
R338 T326 T325 arg2Of MKP-1,(
R339 T327 T325 arg3Of ),(
R340 T331 T328 arg2Of inhibitor,","
R341 T417 T418 arg1Of see,later
R342 T331 T329 arg1Of inhibitor,the
R343 T331 T330 arg1Of inhibitor,endogenous
R344 T331 T332 arg1Of inhibitor,of
R345 T334 T332 arg2Of MAPK,of
R346 T334 T333 arg1Of MAPK,p38
R347 T334 T335 arg1Of MAPK,","
R348 T334 T336 arg1Of MAPK,which
R349 T334 T337 arg1Of MAPK,is
R350 T334 T338 arg1Of MAPK,necessary
R351 T338 T337 arg2Of necessary,is
R352 T417 T419 arg1Of see,in
R353 T338 T339 arg1Of necessary,for
R354 T342 T339 arg2Of translocation,for
R355 T421 T419 arg2Of article,in
R356 T421 T420 arg1Of article,the
R357 T421 T422 arg1Of article,for
R358 T423 T422 arg2Of Editors,for
R359 T424 T417 arg2Of ',see
R360 T424 T425 arg1Of ',Summary
R361 T342 T340 arg1Of translocation,GATA-3
R362 T342 T341 arg1Of translocation,nuclear
R363 T345 T343 arg1Of effects,These
R364 T345 T344 arg1Of effects,inhibitory
R365 T345 T346 arg1Of effects,of
R366 T345 T348 arg1Of effects,are
R367 T345 T349 arg1Of effects,rapid
R368 T345 T351 arg1Of effects,potent
R369 T345 T354 arg1Of effects,prolonged
R370 T347 T346 arg2Of fluticasone,of
R371 T349 T350 arg1Of rapid,","
R372 T350 T353 arg1Of ",",and
R373 T351 T350 arg2Of potent,","
R1046 T1321 T1322 arg1Of Inflammation,in
R1047 T1321 T1334 arg1Of Inflammation,is
R1048 T1321 T1335 arg2Of Inflammation,mediated
R1049 T1324 T1322 arg2Of diseases,in
R1050 T1324 T1323 arg1Of diseases,allergic
R1051 T1324 T1326 arg1Of diseases,as
R1052 T1326 T1325 arg1Of as,such
R1053 T1327 T1328 arg1Of asthma,","
R1054 T1328 T1331 arg1Of ",",and
R1055 T1329 T1328 arg2Of rhinitis,","
R1056 T1331 T1326 arg2Of and,as
R1057 T1331 T1330 arg1Of and,","
R1058 T1333 T1331 arg2Of dermatitis,and
R1059 T1333 T1332 arg1Of dermatitis,atopic
R1060 T1335 T1334 arg2Of mediated,is
R1061 T1335 T1336 arg1Of mediated,via
R1062 T1337 T1336 arg2Of expression,via
R1063 T1337 T1338 arg1Of expression,of
R1064 T1340 T1339 arg1Of cytokines,the
R1065 T1341 T1342 arg1Of interleukin,(
R1066 T1341 T1345 arg1Of interleukin,-4
R1067 T1341 T1346 arg1Of interleukin,","
R1068 T1343 T1342 arg2Of IL,(
R1069 T1344 T1342 arg3Of ),(
R1070 T1346 T1349 arg1Of ",",and
R1071 T1347 T1346 arg2Of IL-5,","
R1072 T1349 T1338 arg2Of and,of
R1073 T1349 T1340 arg1Of and,cytokines
R1074 T1349 T1348 arg1Of and,","
R1075 T1349 T1351 arg1Of and,from
R1076 T1350 T1349 arg2Of IL-13,and
R1077 T1355 T1354 arg2Of Th2,(
R1078 T1356 T1354 arg3Of ),(
R1079 T1357 T1351 arg2Of cells,from
R1080 T1357 T1352 arg1Of cells,T
R1081 T1357 T1353 arg1Of cells,helper-2
R1082 T1357 T1354 arg1Of cells,(
R1083 T1358 T1359 arg1Of IL-4,and
R1084 T1359 T1361 arg1Of and,regulate
R1085 T1360 T1359 arg2Of IL-13,and
R1086 T1361 T1370 arg1Of regulate,whereas
R1087 T1363 T1361 arg2Of expression,regulate
R1088 T1363 T1362 arg1Of expression,the
R1089 T1363 T1364 arg1Of expression,of
R1090 T1363 T1366 arg1Of expression,from
R1091 T1365 T1364 arg2Of IgE,of
R1092 T1368 T1366 arg2Of lymphocytes,from
R1093 T1368 T1367 arg1Of lymphocytes,B
R1094 T1370 T1369 arg1Of whereas,","
R1095 T1371 T1372 arg1Of IL-5,plays
R1096 T1372 T1370 arg2Of plays,whereas
R1097 T1372 T1376 arg1Of plays,in
R1098 T1375 T1372 arg2Of role,plays
R1099 T1375 T1373 arg1Of role,a
R1100 T1375 T1374 arg1Of role,key
R1101 T1378 T1376 arg2Of inflammation,in
R1102 T1378 T1377 arg1Of inflammation,eosinophilic
R1103 T1378 T1379 arg1Of inflammation,[
R1104 T1380 T1379 arg2Of 1,[
R1105 T1381 T1379 arg3Of ],[
R1106 T1383 T1382 arg1Of cytokines,Th2
R1107 T1383 T1384 arg1Of cytokines,are
R1108 T1383 T1385 arg2Of cytokines,regulated
R1109 T1385 T1384 arg2Of regulated,are
R1110 T1392 T1385 arg1Of GATA-3,regulated
R1111 T1392 T1386 arg2Of GATA-3,by
R1112 T1392 T1387 arg1Of GATA-3,the
R1113 T1392 T1388 arg1Of GATA-3,zinc
R1114 T1392 T1389 arg1Of GATA-3,finger
R1115 T1392 T1390 arg1Of GATA-3,transcription
R1116 T1392 T1391 arg1Of GATA-3,factor
R1117 T1392 T1393 arg1Of GATA-3,","
R1118 T1392 T1394 arg1Of GATA-3,which
R1119 T1392 T1395 arg1Of GATA-3,is
R1120 T1392 T1397 arg2Of GATA-3,expressed
R1121 T1397 T1395 arg2Of expressed,is
R1122 T1397 T1396 arg1Of expressed,predominantly
R1123 T1397 T1398 arg1Of expressed,in
R1124 T1397 T1404 arg1Of expressed,","
R1125 T1397 T1405 arg1Of expressed,[
R1126 T1400 T1398 arg2Of cells,in
R1127 T1400 T1399 arg1Of cells,Th2
R1128 T1400 T1401 arg1Of cells,[
R1129 T1402 T1401 arg2Of 2,[
R1130 T1403 T1401 arg3Of ],[
R1131 T1406 T1405 arg2Of 3,[
R1132 T1407 T1405 arg3Of ],[
R1133 T1408 T1409 arg1Of GATA-3,determines
R1134 T1408 T1415 arg1Of GATA-3,activates
R1135 T1409 T1413 arg1Of determines,and
R1136 T1412 T1409 arg2Of differentiation,determines
R1137 T1412 T1410 arg1Of differentiation,Th2
R1138 T1412 T1411 arg1Of differentiation,cell
R1139 T1413 T1432 arg1Of and,[
R1140 T1415 T1413 arg2Of activates,and
R1141 T1415 T1414 arg1Of activates,selectively
R1142 T1415 T1425 arg1Of activates,through
R1143 T1417 T1415 arg2Of promoters,activates
R1144 T1417 T1416 arg1Of promoters,the
R1145 T1417 T1418 arg1Of promoters,of
R1146 T1419 T1420 arg1Of IL-4,","
R1147 T1420 T1423 arg1Of ",",and
R1148 T1421 T1420 arg2Of IL-5,","
R1149 T1423 T1418 arg2Of and,of
R1150 T1423 T1422 arg1Of and,","
R1151 T1424 T1423 arg2Of IL-13,and
R1152 T1426 T1425 arg2Of chromatin,through
R1153 T1426 T1427 arg1Of chromatin,remodelling
R1154 T1429 T1428 arg2Of 4,[
R1155 T1430 T1428 arg3Of ],[
R1156 T1431 T1427 arg2Of –,remodelling
R1157 T1431 T1428 arg1Of –,[
R1158 T1433 T1432 arg2Of 7,[
R1159 T1434 T1432 arg3Of ],[
R1160 T1437 T1435 arg1Of role,The
R1161 T1437 T1436 arg1Of role,key
R1162 T1437 T1438 arg1Of role,of
R1163 T1437 T1440 arg1Of role,in
R1164 T1437 T1444 arg1Of role,has
R1165 T1437 T1445 arg1Of role,been
R1166 T1437 T1446 arg2Of role,demonstrated
R1167 T1439 T1438 arg2Of GATA-3,of
R1168 T1443 T1440 arg2Of inflammation,in
R1169 T1443 T1441 arg1Of inflammation,allergic
R1170 T1443 T1442 arg1Of inflammation,airway
R1171 T1446 T1444 arg2Of demonstrated,has
R1172 T1446 T1445 arg2Of demonstrated,been
R1173 T1446 T1447 arg1Of demonstrated,in
R1174 T1446 T1456 arg1Of demonstrated,in
R1175 T1446 T1465 arg1Of demonstrated,by
R1176 T1446 T1476 arg1Of demonstrated,","
R1177 T1446 T1477 arg1Of demonstrated,[
R1178 T1448 T1447 arg2Of mice,in
R1179 T1452 T1446 arg1Of release,demonstrated
R1180 T1452 T1449 arg2Of release,by
R1181 T1452 T1450 arg1Of release,the
R1182 T1452 T1451 arg2Of release,reduced
R1183 T1452 T1453 arg1Of release,of
R1184 T1455 T1453 arg2Of cytokines,of
R1185 T1455 T1454 arg1Of cytokines,Th2
R1186 T1456 T1464 arg1Of in,and
R1187 T1457 T1456 arg2Of animals,in
R1188 T1457 T1458 arg2Of animals,treated
R1189 T1458 T1459 arg1Of treated,with
R1190 T1461 T1459 arg2Of mutants,with
R1191 T1461 T1460 arg1Of mutants,dominant-negative
R1192 T1461 T1462 arg1Of mutants,of
R1193 T1463 T1462 arg2Of GATA-3,of
R1194 T1465 T1464 arg2Of by,and
R1195 T1467 T1465 arg2Of application,by
R1196 T1467 T1466 arg1Of application,local
R1197 T1467 T1468 arg1Of application,of
R1198 T1467 T1471 arg1Of application,to
R1199 T1470 T1468 arg2Of oligonucleotides,of
R1200 T1470 T1469 arg1Of oligonucleotides,antisense
R1201 T1472 T1471 arg2Of GATA-3,to
R1202 T1472 T1473 arg1Of GATA-3,[
R1203 T1474 T1473 arg2Of 8,[
R1204 T1475 T1473 arg3Of ],[
R1205 T1478 T1477 arg2Of 9,[
R1206 T1479 T1477 arg3Of ],[
R1207 T1483 T1482 arg1Of knock-out,conditional
R1208 T1483 T1484 arg1Of knock-out,of
R1209 T1483 T1488 arg1Of knock-out,in
R1210 T1483 T1490 arg1Of knock-out,reduces
R1211 T1487 T1484 arg2Of gene,of
R1212 T1487 T1485 arg1Of gene,the
R1213 T1487 T1486 arg1Of gene,Gata3
R1214 T1489 T1488 arg2Of mice,in
R1215 T1490 T1480 arg1Of reduces,Furthermore
R1216 T1490 T1481 arg1Of reduces,","
R1217 T1490 T1504 arg1Of reduces,and
R1218 T1491 T1490 arg2Of expression,reduces
R1219 T1491 T1492 arg1Of expression,of
R1220 T1491 T1496 arg1Of expression,vitro
R1221 T1491 T1499 arg1Of expression,vivo
R1222 T1491 T1500 arg1Of expression,[
R1223 T1494 T1492 arg2Of cytokines,of
R1224 T1494 T1493 arg1Of cytokines,Th2
R1225 T1496 T1495 arg1Of vitro,in
R1226 T1496 T1497 arg1Of vitro,and
R1227 T1499 T1497 arg2Of vivo,and
R1228 T1499 T1498 arg1Of vivo,in
R1229 T1501 T1500 arg2Of 10,[
R1230 T1502 T1500 arg3Of ],[
R1231 T1504 T1503 arg1Of and,","
R1232 T1506 T1505 arg1Of results,similar
R1233 T1506 T1507 arg1Of results,have
R1234 T1506 T1508 arg1Of results,been
R1235 T1506 T1509 arg2Of results,reported
R1236 T1509 T1504 arg2Of reported,and
R1237 T1509 T1507 arg2Of reported,have
R1238 T1509 T1508 arg2Of reported,been
R1239 T1509 T1510 arg1Of reported,in
R1240 T1514 T1510 arg2Of lymphocytes,in
R1241 T1514 T1511 arg2Of lymphocytes,isolated
R1242 T1514 T1512 arg1Of lymphocytes,murine
R1243 T1514 T1513 arg1Of lymphocytes,CD4+
R1244 T1514 T1515 arg1Of lymphocytes,[
R1245 T1516 T1515 arg2Of 11,[
R1246 T1517 T1515 arg3Of ],[
R1247 T1520 T1521 arg1Of knockdown,of
R1248 T1520 T1530 arg1Of knockdown,results
R1249 T1523 T1521 arg2Of expression,of
R1250 T1523 T1522 arg1Of expression,GATA-3
R1251 T1523 T1524 arg1Of expression,using
R1252 T1524 T1526 arg1Of using,in
R1253 T1525 T1524 arg2Of siRNA,using
R1254 T1529 T1526 arg2Of cells,in
R1255 T1529 T1527 arg1Of cells,human
R1256 T1529 T1528 arg1Of cells,T
R1257 T1530 T1518 arg1Of results,Finally
R1258 T1530 T1519 arg1Of results,","
R1259 T1530 T1531 arg1Of results,in
R1260 T1530 T1538 arg1Of results,[
R1261 T1532 T1531 arg2Of loss,in
R1262 T1532 T1533 arg1Of loss,of
R1263 T1537 T1533 arg2Of expression,of
R1264 T1537 T1534 arg1Of expression,anti-CD3/CD28-mediated
R1265 T1537 T1535 arg1Of expression,Th2
R1266 T1537 T1536 arg1Of expression,cytokine
R1267 T1539 T1538 arg2Of 12,[
R1268 T1540 T1538 arg3Of ],[
R1269 T1542 T1541 arg2Of order,In
R1270 T1542 T1543 arg1Of order,for
R1271 T1544 T1543 arg2Of GATA-3,for
R1272 T1544 T1546 arg1Of GATA-3,regulate
R1273 T1546 T1543 arg3Of regulate,for
R1274 T1546 T1545 arg1Of regulate,to
R1275 T1548 T1546 arg2Of expression,regulate
R1276 T1548 T1547 arg1Of expression,gene
R1277 T1550 T1551 arg1Of it,must
R1278 T1550 T1552 arg1Of it,translocate
R1279 T1552 T1541 arg1Of translocate,In
R1280 T1552 T1549 arg1Of translocate,","
R1281 T1552 T1551 arg2Of translocate,must
R1282 T1552 T1553 arg1Of translocate,from
R1283 T1555 T1553 arg2Of cytoplasm,from
R1284 T1555 T1554 arg1Of cytoplasm,the
R1285 T1555 T1556 arg1Of cytoplasm,into
R1286 T1558 T1556 arg2Of nucleus,into
R1287 T1558 T1557 arg1Of nucleus,the
R1288 T1558 T1559 modOf nucleus,to
R1289 T1560 T1559 arg1Of access,to
R1290 T1563 T1560 arg2Of genes,access
R1291 T1563 T1561 arg1Of genes,its
R1292 T1563 T1562 arg1Of genes,target
R1293 T1566 T1564 arg2Of expression,Enhanced
R1294 T1566 T1565 arg1Of expression,nuclear
R1295 T1566 T1567 arg1Of expression,of
R1296 T1566 T1574 arg1Of expression,was
R1297 T1566 T1576 arg2Of expression,demonstrated
R1298 T1566 T1585 arg1Of expression,was
R1299 T1566 T1587 arg2Of expression,confirmed
R1300 T1568 T1567 arg2Of GATA-3,of
R1301 T1568 T1569 arg1Of GATA-3,following
R1302 T1573 T1569 arg2Of activation,following
R1303 T1573 T1570 arg1Of activation,T
R1304 T1573 T1571 arg1Of activation,cell
R1305 T1573 T1572 arg1Of activation,receptor
R1306 T1576 T1574 arg2Of demonstrated,was
R1307 T1576 T1575 arg1Of demonstrated,first
R1308 T1576 T1577 arg1Of demonstrated,in
R1309 T1576 T1581 arg1Of demonstrated,[
R1310 T1576 T1584 arg1Of demonstrated,and
R1311 T1580 T1577 arg2Of cells,in
R1312 T1580 T1578 arg1Of cells,murine
R1313 T1580 T1579 arg1Of cells,T
R1314 T1582 T1581 arg2Of 13,[
R1315 T1583 T1581 arg3Of ],[
R1316 T1587 T1584 arg2Of confirmed,and
R1317 T1587 T1585 arg2Of confirmed,was
R1318 T1587 T1586 arg1Of confirmed,recently
R1319 T1587 T1588 arg1Of confirmed,in
R1320 T1587 T1592 arg1Of confirmed,following
R1321 T1591 T1588 arg2Of cells,in
R1322 T1591 T1589 arg1Of cells,human
R1323 T1591 T1590 arg1Of cells,T
R1324 T1595 T1593 arg1Of receptor,T
R1325 T1595 T1594 arg1Of receptor,cell
R1326 T1595 T1596 arg1Of receptor,and
R1327 T1596 T1592 arg2Of and,following
R1328 T1598 T1596 arg2Of stimulation,and
R1329 T1598 T1597 arg1Of stimulation,co-receptor
R1330 T1598 T1599 arg1Of stimulation,[
R1331 T1600 T1599 arg2Of 12,[
R1332 T1601 T1599 arg3Of ],[
R1333 T1602 T1603 arg1Of GATA-3,contains
R1334 T1602 T1613 arg1Of GATA-3,is
R1335 T1602 T1614 arg2Of GATA-3,transported
R1336 T1603 T1609 arg1Of contains,[
R1337 T1603 T1612 arg1Of contains,and
R1338 T1608 T1603 arg2Of signal,contains
R1339 T1608 T1604 arg1Of signal,a
R1340 T1608 T1605 arg1Of signal,classical
R1341 T1608 T1606 arg1Of signal,nuclear
R1342 T1608 T1607 arg1Of signal,import
R1343 T1610 T1609 arg2Of 14,[
R1344 T1611 T1609 arg3Of ],[
R1345 T1614 T1612 arg2Of transported,and
R1346 T1614 T1613 arg2Of transported,is
R1347 T1614 T1615 arg1Of transported,into
R1348 T1614 T1618 arg1Of transported,by
R1349 T1614 T1630 arg1Of transported,[
R1350 T1617 T1615 arg2Of nucleus,into
R1351 T1617 T1616 arg1Of nucleus,the
R1352 T1623 T1618 arg2Of importin-α,by
R1353 T1623 T1619 arg1Of importin-α,the
R1354 T1623 T1620 arg1Of importin-α,nuclear
R1355 T1623 T1621 arg1Of importin-α,import
R1356 T1623 T1622 arg1Of importin-α,protein
R1357 T1623 T1624 arg1Of importin-α,(
R1358 T1626 T1624 arg2Of known,(
R1359 T1626 T1625 arg1Of known,also
R1360 T1626 T1627 arg1Of known,as
R1361 T1628 T1627 arg2Of karyopherin-α,as
R1362 T1629 T1624 arg3Of ),(
R1363 T1631 T1630 arg2Of 12,[
R1364 T1632 T1630 arg3Of ],[
R1365 T1633 T1634 arg1Of Deletion,of
R1366 T1633 T1652 arg1Of Deletion,prevents
R1367 T1636 T1634 arg2Of region,of
R1368 T1636 T1635 arg1Of region,a
R1369 T1636 T1637 arg1Of region,encompassing
R1370 T1642 T1639 arg1Of sequence,GATA-3
R1371 T1642 T1640 arg1Of sequence,nuclear
R1372 T1642 T1641 arg1Of sequence,localisation
R1373 T1642 T1643 arg1Of sequence,(
R1374 T1644 T1643 arg2Of NLS,(
R1375 T1645 T1643 arg3Of ),(
R1376 T1646 T1637 arg2Of region,encompassing
R1377 T1646 T1638 arg1Of region,the
R1378 T1646 T1642 arg1Of region,sequence
R1379 T1646 T1647 arg1Of region,in
R1380 T1648 T1649 arg1Of murine,and
R1381 T1650 T1649 arg2Of human,and
R1382 T1651 T1647 arg2Of cells,in
R1383 T1651 T1648 arg1Of cells,murine
R1384 T1651 T1650 arg1Of cells,human
R1385 T1652 T1659 arg1Of prevents,","
R1386 T1652 T1660 arg1Of prevents,[
R1387 T1655 T1652 arg2Of localisation,prevents
R1388 T1655 T1653 arg1Of localisation,its
R1389 T1655 T1654 arg1Of localisation,nuclear
R1390 T1655 T1656 arg1Of localisation,[
R1391 T1657 T1656 arg2Of 12,[
R1392 T1658 T1656 arg3Of ],[
R1393 T1661 T1660 arg2Of 14,[
R1394 T1662 T1660 arg3Of ],[
R1395 T1664 T1663 arg1Of affinity,The
R1396 T1664 T1665 arg1Of affinity,of
R1397 T1664 T1669 arg1Of affinity,is
R1398 T1664 T1670 arg2Of affinity,regulated
R1399 T1668 T1665 arg2Of interaction,of
R1400 T1668 T1666 arg1Of interaction,the
R1401 T1668 T1667 arg1Of interaction,importin-α–NLS
R1402 T1670 T1669 arg2Of regulated,is
R1403 T1670 T1677 arg1Of regulated,and
R1404 T1672 T1670 arg1Of phosphorylation,regulated
R1405 T1672 T1671 arg2Of phosphorylation,by
R1406 T1672 T1673 arg1Of phosphorylation,[
R1407 T1674 T1673 arg2Of 15,[
R1408 T1675 T1673 arg3Of ],[
R1409 T1677 T1676 arg1Of and,","
R1410 T1678 T1679 arg1Of we,have
R1411 T1678 T1680 arg1Of we,shown
R1412 T1680 T1677 arg2Of shown,and
R1413 T1680 T1679 arg2Of shown,have
R1414 T1685 T1682 arg1Of kinase,p38
R1415 T1685 T1683 arg1Of kinase,mitogen-activated
R1416 T1685 T1684 arg1Of kinase,protein
R1417 T1685 T1686 arg1Of kinase,(
R1418 T1685 T1689 arg1Of kinase,plays
R1419 T1687 T1686 arg2Of MAPK,(
R1420 T1688 T1686 arg3Of ),(
R1421 T1689 T1680 arg2Of plays,shown
R1422 T1689 T1681 arg1Of plays,that
R1423 T1689 T1693 arg1Of plays,in
R1424 T1689 T1708 arg1Of plays,[
R1425 T1692 T1689 arg2Of role,plays
R1426 T1692 T1690 arg1Of role,a
R1427 T1692 T1691 arg1Of role,critical
R1428 T1694 T1693 arg2Of phosphorylating,in
R1429 T1694 T1696 modOf phosphorylating,to
R1430 T1695 T1694 arg2Of GATA-3,phosphorylating
R1431 T1697 T1696 arg1Of enhance,to
R1432 T1699 T1697 arg2Of interaction,enhance
R1433 T1699 T1698 arg1Of interaction,its
R1434 T1699 T1700 arg1Of interaction,with
R1435 T1699 T1705 arg1Of interaction,into
R1436 T1701 T1702 arg1Of importin-α,and
R1437 T1703 T1702 arg2Of subsequent,and
R1438 T1704 T1700 arg2Of transport,with
R1439 T1704 T1701 arg1Of transport,importin-α
R1440 T1704 T1703 arg1Of transport,subsequent
R1441 T1707 T1705 arg2Of nucleus,into
R1442 T1707 T1706 arg1Of nucleus,the
R1443 T1709 T1708 arg2Of 12,[
R1444 T1710 T1708 arg3Of ],[
R1445 T1711 T1712 arg1Of Corticosteroids,are
R1446 T1711 T1714 arg1Of Corticosteroids,effective
R1447 T1712 T1721 arg1Of are,","
R1448 T1712 T1722 arg1Of are,with
R1449 T1712 T1734 arg1Of are,[
R1450 T1714 T1712 arg2Of effective,are
R1451 T1714 T1713 arg1Of effective,highly
R1452 T1714 T1715 arg1Of effective,in
R1453 T1717 T1715 arg2Of treatment,in
R1454 T1717 T1716 arg1Of treatment,the
R1455 T1717 T1718 arg1Of treatment,of
R1456 T1720 T1718 arg2Of inflammation,of
R1457 T1720 T1719 arg1Of inflammation,allergic
R1458 T1724 T1722 arg2Of suppression,with
R1459 T1724 T1723 arg1Of suppression,marked
R1460 T1724 T1725 arg1Of suppression,of
R1461 T1724 T1728 arg1Of suppression,in
R1462 T1727 T1725 arg2Of cytokines,of
R1463 T1727 T1726 arg1Of cytokines,Th2
R1464 T1729 T1728 arg2Of airways,in
R1465 T1729 T1730 arg1Of airways,of
R1466 T1731 T1730 arg2Of patients,of
R1467 T1731 T1732 arg1Of patients,with
R1468 T1733 T1732 arg2Of asthma,with
R1469 T1735 T1734 arg2Of 16,[
R1470 T1736 T1734 arg3Of ],[
R1471 T1737 T1738 arg1Of Corticosteroids,mediate
R1472 T1738 T1742 arg1Of mediate,through
R1473 T1741 T1738 arg2Of effects,mediate
R1474 T1741 T1739 arg1Of effects,their
R1475 T1741 T1740 arg1Of effects,anti-inflammatory
R1476 T1743 T1742 arg2Of binding,through
R1477 T1743 T1744 arg1Of binding,to
R1478 T1746 T1744 arg2Of receptors,to
R1479 T1746 T1745 arg1Of receptors,glucocorticoid
R1480 T1746 T1747 arg1Of receptors,(
R1481 T1746 T1750 arg1Of receptors,","
R1482 T1746 T1751 arg1Of receptors,which
R1483 T1746 T1753 arg1Of receptors,translocate
R1484 T1748 T1747 arg2Of GRs,(
R1485 T1749 T1747 arg3Of ),(
R1486 T1753 T1752 arg1Of translocate,then
R1487 T1753 T1754 arg1Of translocate,to
R1488 T1756 T1754 arg2Of nucleus,to
R1489 T1756 T1755 arg1Of nucleus,the
R1490 T1756 T1757 arg1Of nucleus,where
R1491 T1758 T1759 arg1Of they,interact
R1492 T1759 T1757 arg2Of interact,where
R1493 T1759 T1760 arg1Of interact,with
R1494 T1763 T1760 arg2Of elements,with
R1495 T1763 T1761 arg1Of elements,glucocorticoid
R1496 T1763 T1762 arg1Of elements,response
R1497 T1763 T1764 arg1Of elements,(
R1498 T1763 T1767 arg1Of elements,in
R1499 T1765 T1764 arg2Of GREs,(
R1500 T1766 T1764 arg3Of ),(
R1501 T1770 T1767 arg2Of regions,in
R1502 T1770 T1768 arg1Of regions,the
R1503 T1770 T1769 arg1Of regions,promoter
R1504 T1770 T1771 arg1Of regions,of
R1505 T1773 T1771 arg2Of genes,of
R1506 T1773 T1772 arg1Of genes,steroid-sensitive
R1507 T1777 T1776 arg2Of GR,activated
R1508 T1777 T1778 arg1Of GR,interacts
R1509 T1777 T1783 arg1Of GR,suppress
R1510 T1777 T1790 arg1Of GR,inhibiting
R1511 T1778 T1774 arg1Of interacts,Alternatively
R1512 T1778 T1775 arg1Of interacts,","
R1513 T1778 T1779 arg1Of interacts,with
R1514 T1778 T1817 arg1Of interacts,","
R1515 T1778 T1818 arg1Of interacts,[
R1516 T1781 T1779 arg2Of molecules,with
R1517 T1781 T1780 arg1Of molecules,coactivator
R1518 T1783 T1778 arg2Of suppress,interacts
R1519 T1783 T1782 arg1Of suppress,to
R1520 T1783 T1789 arg1Of suppress,by
R1521 T1785 T1783 arg2Of expression,suppress
R1522 T1785 T1784 arg1Of expression,the
R1523 T1785 T1786 arg1Of expression,of
R1524 T1788 T1786 arg2Of genes,of
R1525 T1788 T1787 arg1Of genes,inflammatory
R1526 T1790 T1789 arg2Of inhibiting,by
R1527 T1790 T1804 arg1Of inhibiting,through
R1528 T1792 T1790 arg2Of action,inhibiting
R1529 T1792 T1791 arg1Of action,the
R1530 T1792 T1793 arg1Of action,of
R1531 T1796 T1793 arg2Of factors,of
R1532 T1796 T1794 arg1Of factors,proinflammatory
R1533 T1796 T1795 arg1Of factors,transcription
R1534 T1796 T1798 arg1Of factors,as
R1535 T1798 T1797 arg1Of as,such
R1536 T1800 T1798 arg2Of factor-κB,as
R1537 T1800 T1799 arg1Of factor-κB,nuclear
R1538 T1800 T1801 arg1Of factor-κB,(
R1539 T1802 T1801 arg2Of NF-κB,(
R1540 T1803 T1801 arg3Of ),(
R1541 T1806 T1804 arg2Of recruitment,through
R1542 T1806 T1805 arg1Of recruitment,the
R1543 T1806 T1807 arg1Of recruitment,of
R1544 T1809 T1807 arg2Of molecules,of
R1545 T1809 T1808 arg1Of molecules,co-repressor
R1546 T1809 T1811 arg1Of molecules,as
R1547 T1811 T1810 arg1Of as,such
R1548 T1813 T1811 arg2Of deacetylase-2,as
R1549 T1813 T1812 arg1Of deacetylase-2,histone
R1550 T1813 T1814 arg1Of deacetylase-2,[
R1551 T1815 T1814 arg2Of 17,[
R1552 T1816 T1814 arg3Of ],[
R1553 T1819 T1818 arg2Of 18,[
R1554 T1820 T1818 arg3Of ],[
R1555 T1822 T1821 arg1Of localisation,Nuclear
R1556 T1822 T1823 arg1Of localisation,and
R1557 T1823 T1827 arg1Of and,is
R1558 T1823 T1828 arg2Of and,mediated
R1559 T1824 T1823 arg2Of retention,and
R1560 T1824 T1825 arg1Of retention,of
R1561 T1826 T1825 arg2Of GR,of
R1562 T1828 T1827 arg2Of mediated,is
R1563 T1828 T1829 arg1Of mediated,through
R1564 T1828 T1840 arg1Of mediated,","
R1565 T1828 T1841 arg1Of mediated,by
R1566 T1828 T1850 arg1Of mediated,by
R1567 T1828 T1855 arg1Of mediated,via
R1568 T1828 T1866 arg1Of mediated,[
R1569 T1834 T1830 arg1Of NL1,the
R1570 T1834 T1831 arg1Of NL1,nuclear
R1571 T1834 T1832 arg1Of NL1,localisation
R1572 T1834 T1833 arg1Of NL1,sequences
R1573 T1834 T1835 arg1Of NL1,and
R1574 T1835 T1829 arg2Of and,through
R1575 T1836 T1835 arg2Of NL2,and
R1576 T1836 T1837 arg1Of NL2,[
R1577 T1838 T1837 arg2Of 19,[
R1578 T1839 T1837 arg3Of ],[
R1579 T1841 T1849 arg1Of by,and
R1580 T1844 T1841 arg2Of signals,by
R1581 T1844 T1842 arg1Of signals,nuclear
R1582 T1844 T1843 arg1Of signals,retention
R1583 T1844 T1845 arg1Of signals,[
R1584 T1846 T1845 arg2Of 20,[
R1585 T1847 T1845 arg3Of ],[
R1586 T1849 T1848 arg1Of and,","
R1587 T1850 T1849 arg2Of by,and
R1588 T1851 T1850 arg2Of control,by
R1589 T1851 T1852 arg1Of control,of
R1590 T1854 T1852 arg2Of export,of
R1591 T1854 T1853 arg1Of export,nuclear
R1592 T1862 T1861 arg2Of CRM-1,(
R1593 T1863 T1861 arg3Of ),(
R1594 T1865 T1855 arg2Of pathway,via
R1595 T1865 T1856 arg1Of pathway,a
R1596 T1865 T1857 arg1Of pathway,chromosomal
R1597 T1865 T1858 arg1Of pathway,region
R1598 T1865 T1859 arg1Of pathway,maintenance
R1599 T1865 T1860 arg1Of pathway,1
R1600 T1865 T1861 arg1Of pathway,(
R1601 T1865 T1864 arg1Of pathway,dependent
R1602 T1867 T1866 arg2Of 21,[
R1603 T1868 T1866 arg3Of ],[
R1604 T1869 T1870 arg1Of NL1,","
R1605 T1869 T1871 arg1Of NL1,which
R1606 T1869 T1872 arg1Of NL1,is
R1607 T1869 T1873 arg1Of NL1,similar
R1608 T1869 T1879 arg1Of NL1,binds
R1609 T1873 T1872 arg2Of similar,is
R1610 T1873 T1874 arg1Of similar,to
R1611 T1877 T1874 arg2Of NLS,to
R1612 T1877 T1875 arg1Of NLS,the
R1613 T1877 T1876 arg1Of NLS,SV40
R1614 T1879 T1878 arg1Of binds,","
R1615 T1879 T1880 arg1Of binds,to
R1616 T1881 T1880 arg2Of importin-α,to
R1617 T1881 T1882 arg1Of importin-α,[
R1618 T1883 T1882 arg2Of 22,[
R1619 T1884 T1882 arg3Of ],[
R1620 T1885 T1886 arg1Of NL1,is
R1621 T1885 T1887 arg2Of NL1,activated
R1622 T1887 T1886 arg2Of activated,is
R1623 T1887 T1889 arg1Of activated,by
R1624 T1887 T1902 arg1Of activated,by
R1625 T1889 T1888 arg1Of by,both
R1626 T1889 T1901 arg1Of by,and
R1627 T1891 T1889 arg2Of agonists,by
R1628 T1891 T1890 arg1Of agonists,glucocorticoid
R1629 T1891 T1893 arg1Of agonists,as
R1630 T1893 T1892 arg1Of as,such
R1631 T1894 T1895 arg1Of dexamethasone,and
R1632 T1895 T1893 arg2Of and,as
R1633 T1897 T1895 arg2Of propionate,and
R1634 T1897 T1896 arg1Of propionate,fluticasone
R1635 T1897 T1898 arg1Of propionate,(
R1636 T1899 T1898 arg2Of FP,(
R1637 T1900 T1898 arg3Of ),(
R1638 T1902 T1901 arg2Of by,and
R1639 T1904 T1902 arg2Of antagonists,by
R1640 T1904 T1903 arg1Of antagonists,glucocorticoid
R1641 T1904 T1906 arg1Of antagonists,as
R1642 T1906 T1905 arg1Of as,such
R1643 T1907 T1906 arg2Of mifepristone,as
R1644 T1907 T1908 arg1Of mifepristone,(
R1645 T1907 T1911 arg1Of mifepristone,[
R1646 T1909 T1908 arg2Of RU486,(
R1647 T1910 T1908 arg3Of ),(
R1648 T1912 T1911 arg2Of 23,[
R1649 T1913 T1911 arg3Of ],[
R1650 T1914 T1915 arg1Of NL1,can
R1651 T1914 T1916 arg1Of NL1,be
R1652 T1914 T1917 arg2Of NL1,mutated
R1653 T1917 T1915 arg2Of mutated,can
R1654 T1917 T1916 arg2Of mutated,be
R1655 T1917 T1919 arg1Of mutated,and
R1656 T1919 T1918 arg1Of and,","
R1657 T1922 T1920 arg1Of GR,the
R1658 T1922 T1921 arg1Of GR,resulting
R1659 T1922 T1924 arg1Of GR,translocates
R1660 T1924 T1919 arg2Of translocates,and
R1661 T1924 T1923 arg1Of translocates,still
R1662 T1924 T1925 arg1Of translocates,to
R1663 T1924 T1928 arg1Of translocates,in
R1664 T1924 T1934 arg1Of translocates,via
R1665 T1927 T1925 arg2Of nucleus,to
R1666 T1927 T1926 arg1Of nucleus,the
R1667 T1928 T1933 arg1Of in,but
R1668 T1929 T1928 arg2Of response,in
R1669 T1929 T1930 arg1Of response,to
R1670 T1931 T1930 arg2Of ligands,to
R1671 T1933 T1932 arg1Of but,","
R1672 T1934 T1933 arg2Of via,but
R1673 T1935 T1934 arg2Of interaction,via
R1674 T1935 T1936 arg1Of interaction,with
R1675 T1937 T1936 arg2Of importin,with
R1676 T1937 T1938 arg1Of importin,7
R1677 T1937 T1939 arg1Of importin,","
R1678 T1941 T1939 arg2Of event,","
R1679 T1941 T1940 arg1Of event,an
R1680 T1941 T1942 arg1Of event,that
R1681 T1941 T1943 arg1Of event,requires
R1682 T1943 T1948 arg1Of requires,[
R1683 T1990 T1987 arg2Of and,of
R1684 T1947 T1943 arg2Of component,requires
R1685 T1992 T1993 arg1Of import,including
R1686 T1994 T1993 arg2Of chaperones,including
R1687 T1994 T1996 arg1Of chaperones,as
R1688 T1947 T1944 arg1Of component,an
R1689 T1996 T1995 arg1Of as,such
R1690 T1997 T1998 arg1Of Hsp90,and
R1691 T1947 T1945 arg1Of component,as-yet
R1692 T1998 T1996 arg2Of and,as
R1693 T1998 T2001 arg1Of and,[
R1694 T1947 T1946 arg1Of component,unknown
R1695 T2000 T1998 arg2Of immunophilins,and
R1696 T2000 T1999 arg1Of immunophilins,other
R1697 T1949 T1948 arg2Of 23,[
R1698 T2002 T2001 arg2Of 24,[
R1699 T2003 T2001 arg3Of ],[
R1700 T2004 T2005 arg1Of –,[
R1701 T2004 T2008 arg1Of –,and
R1702 T1950 T1948 arg3Of ],[
R1703 T2006 T2005 arg2Of 26,[
R1704 T2007 T2005 arg3Of ],[
R1705 T2008 T1990 arg2Of and,and
R1706 T2008 T1991 arg1Of and,nuclear
R1707 T2008 T1992 arg1Of and,import
R1708 T1951 T1952 arg1Of NL2,is
R1709 T2010 T2008 arg2Of proteins,and
R1710 T2010 T2009 arg1Of proteins,FK506-binding
R1711 T2010 T2011 arg1Of proteins,that
R1712 T2010 T2012 arg1Of proteins,may
R1713 T2010 T2013 arg1Of proteins,be
R1714 T2010 T2014 arg2Of proteins,linked
R1715 T1951 T1954 arg2Of NL2,defined
R1716 T2014 T2012 arg2Of linked,may
R1717 T2014 T2013 arg2Of linked,be
R1718 T2014 T2015 arg1Of linked,to
R1719 T1954 T1952 arg2Of defined,is
R1720 T2016 T2017 arg1Of dynein,and/or
R1721 T2017 T2015 arg2Of and/or,to
R1722 T2017 T2020 arg1Of and/or,[
R1723 T2019 T2017 arg2Of isomerase,and/or
R1724 T2019 T2018 arg1Of isomerase,peptidylprolyl
R1725 T2021 T2020 arg2Of 27,[
R1726 T2022 T2020 arg3Of ],[
R1727 T1954 T1953 arg1Of defined,poorly
R1728 T1954 T1955 arg1Of defined,","
R1729 T2025 T2024 arg2Of 28,[
R1730 T1954 T1956 modOf defined,residing
R1731 T2026 T2024 arg3Of ],[
R1732 T1954 T1962 arg1Of defined,and
R1733 T1956 T1957 arg1Of residing,in
R1734 T2031 T2029 arg1Of basis,the
R1735 T2031 T2030 arg1Of basis,molecular
R1736 T2031 T2032 arg1Of basis,for
R1737 T2031 T2040 arg1Of basis,is
R1738 T2031 T2043 arg2Of basis,understood
R1739 T1960 T1957 arg2Of domain,in
R1740 T2034 T2032 arg2Of inhibition,for
R1741 T2034 T2033 arg1Of inhibition,the
R1742 T2034 T2035 arg1Of inhibition,of
R1743 T2034 T2038 arg1Of inhibition,by
R1744 T2037 T2035 arg2Of cytokines,of
R1745 T2037 T2036 arg1Of cytokines,Th2
R1746 T2039 T2038 arg2Of corticosteroids,by
R1747 T1960 T1958 arg1Of domain,the
R1748 T1960 T1959 arg1Of domain,ligand-binding
R1749 T2043 T2027 arg1Of understood,However
R1750 T2043 T2028 arg1Of understood,","
R1751 T2043 T2040 arg2Of understood,is
R1752 T2043 T2041 arg1Of understood,not
R1753 T2043 T2042 arg1Of understood,well
R1754 T2043 T2044 arg1Of understood,","
R1755 T2043 T2045 arg1Of understood,because
R1756 T1962 T1961 arg1Of and,","
R1757 T2047 T2046 arg1Of genes,the
R1758 T2047 T2048 arg1Of genes,encoding
R1759 T2047 T2055 arg1Of genes,do
R1760 T2047 T2057 arg1Of genes,have
R1761 T1964 T1963 arg1Of less,much
R1762 T2047 T2066 arg1Of genes,are
R1763 T2047 T2069 arg2Of genes,regulated
R1764 T2049 T2050 arg1Of IL-4,","
R1765 T2050 T2053 arg1Of ",",and
R1766 T1964 T1965 arg1Of less,is
R1767 T1964 T1966 arg2Of less,known
R1768 T1966 T1962 arg2Of known,and
R1769 T2051 T2050 arg2Of IL-5,","
R1770 T2053 T2048 arg2Of and,encoding
R1771 T2053 T2052 arg1Of and,","
R1772 T2054 T2053 arg2Of IL-13,and
R1773 T2057 T2055 arg2Of have,do
R1774 T2057 T2056 arg1Of have,not
R1775 T2057 T2065 arg1Of have,and
R1776 T1966 T1965 arg2Of known,is
R1777 T1966 T1967 arg1Of known,about
R1778 T2061 T2057 arg2Of sequence,have
R1779 T2061 T2058 arg1Of sequence,any
R1780 T2061 T2059 arg1Of sequence,recognisable
R1781 T2061 T2060 arg1Of sequence,GRE
R1782 T2061 T2062 arg1Of sequence,[
R1783 T2063 T2062 arg2Of 29,[
R1784 T1969 T1967 arg2Of mechanism,about
R1785 T2064 T2062 arg3Of ],[
R1786 T2065 T2045 arg2Of and,because
R1787 T2065 T2079 arg1Of and,[
R1788 T2068 T2067 arg1Of partly,only
R1789 T1969 T1968 arg1Of mechanism,its
R1790 T2069 T2065 arg2Of regulated,and
R1791 T2069 T2066 arg2Of regulated,are
R1792 T2069 T2068 arg1Of regulated,partly
R1793 T2069 T2072 arg1Of regulated,in
R1794 T2069 T2075 arg1Of regulated,[
R1795 T2069 T2078 arg1Of regulated,–
R1796 T2071 T2069 arg1Of NF-κB,regulated
R1797 T2071 T2070 arg2Of NF-κB,by
R1798 T1969 T1970 arg1Of mechanism,of
R1799 T1972 T1970 arg2Of import,of
R1800 T2074 T2072 arg2Of cells,in
R1801 T2074 T2073 arg1Of cells,human
R1802 T2076 T2075 arg2Of 30,[
R1803 T2077 T2075 arg3Of ],[
R1804 T1972 T1971 arg1Of import,GR
R1805 T1972 T1973 arg1Of import,[
R1806 T2080 T2079 arg2Of 32,[
R1807 T1974 T1973 arg2Of 24,[
R1808 T2081 T2079 arg3Of ],[
R1809 T2083 T2084 arg1Of overexpression,and
R1810 T1975 T1973 arg3Of ],[
R1811 T2085 T2084 arg2Of CAT-reporter,and
R1812 T2086 T2082 arg2Of genes,Using
R1813 T2086 T2083 arg1Of genes,overexpression
R1814 T2086 T2085 arg1Of genes,CAT-reporter
R1815 T1977 T1976 arg1Of variety,A
R1816 T1977 T1978 arg1Of variety,of
R1817 T1977 T1981 arg1Of variety,are
R1818 T1977 T1983 arg1Of variety,important
R1819 T1980 T1978 arg2Of factors,of
R1820 T2088 T2089 arg1Of Lavender,and
R1821 T2089 T2082 arg1Of and,Using
R1822 T2089 T2094 arg1Of and,have
R1823 T2089 T2095 arg1Of and,shown
R1824 T2090 T2089 arg2Of colleagues,and
R1825 T2090 T2091 arg1Of colleagues,[
R1826 T2092 T2091 arg2Of 33,[
R1827 T2093 T2091 arg3Of ],[
R1828 T1980 T1979 arg1Of factors,other
R1829 T2095 T2082 modOf shown,Using
R1830 T1981 T1982 arg1Of are,also
R1831 T1981 T2023 arg1Of are,","
R1832 T1981 T2024 arg1Of are,[
R1833 T2095 T2087 arg1Of shown,","
R1834 T2095 T2094 arg2Of shown,have
R1835 T1983 T1981 arg2Of important,are
R1836 T2097 T2098 arg1Of GR,reduced
R1837 T2098 T2095 arg2Of reduced,shown
R1838 T2098 T2096 arg1Of reduced,that
R1839 T1983 T1984 arg1Of important,for
R1840 T2100 T2101 arg1Of IL-5,and
R1841 T1986 T1984 arg2Of regulation,for
R1842 T2102 T2101 arg2Of -13,and
R1843 T2104 T2098 arg2Of activity,reduced
R1844 T2104 T2099 arg1Of activity,GATA-3-mediated
R1845 T2104 T2100 arg1Of activity,IL-5
R1846 T2104 T2102 arg1Of activity,-13
R1847 T2104 T2103 arg1Of activity,promoter
R1848 T2104 T2105 arg1Of activity,in
R1849 T1986 T1985 arg1Of regulation,the
R1850 T1986 T1987 arg1Of regulation,of
R1851 T2109 T2105 arg2Of cells,in
R1852 T2109 T2106 arg1Of cells,human
R1853 T2109 T2107 arg1Of cells,CD4+
R1854 T2109 T2108 arg1Of cells,T
R1855 T1989 T1988 arg1Of activation,GR
R1856 T2111 T2110 arg1Of authors,The
R1857 T2111 T2112 arg1Of authors,postulated
R1858 T2115 T2114 arg1Of recruitment,local
R1859 T2115 T2116 arg1Of recruitment,of
R1860 T2115 T2118 arg1Of recruitment,may
R1861 T2115 T2119 arg1Of recruitment,alter
R1862 T1989 T1990 arg1Of activation,and
R1863 T2117 T2116 arg2Of GR,of
R1864 T2184 T2183 arg2Of anti-CD28,and
R1865 T2119 T2112 arg2Of alter,postulated
R1866 T2119 T2113 arg1Of alter,that
R1867 T2119 T2118 arg2Of alter,may
R1868 T2121 T2119 arg2Of ability,alter
R1869 T2121 T2120 arg1Of ability,the
R1870 T2185 T2180 arg1Of antibodies,activated
R1871 T2121 T2122 arg1Of ability,of
R1872 T2123 T2122 arg2Of GATA-3,of
R1873 T2123 T2125 modOf GATA-3,to
R1874 T2126 T2124 arg1Of bind,either
R1875 T2126 T2125 arg1Of bind,to
R1876 T2126 T2127 arg1Of bind,to
R1877 T2185 T2181 arg2Of antibodies,by
R1878 T2185 T2182 arg1Of antibodies,anti-CD3
R1879 T2130 T2127 arg2Of site,to
R1880 T2185 T2184 arg1Of antibodies,anti-CD28
R1881 T2130 T2128 arg1Of site,its
R1882 T2130 T2129 arg1Of site,target
R1883 T2130 T2131 arg1Of site,","
R1884 T2187 T2186 arg1Of vitro,in
R1885 T2133 T2132 arg1Of cause,to
R1886 T2133 T2137 arg1Of cause,or
R1887 T2135 T2133 arg2Of up-regulation,cause
R1888 T2135 T2134 arg1Of up-regulation,transcriptional
R1889 T2188 T2190 arg1Of We,studied
R1890 T2137 T2131 arg2Of or,","
R1891 T2137 T2136 arg1Of or,","
R1892 T2139 T2137 arg2Of maintain,or
R1893 T2139 T2138 arg1Of maintain,to
R1894 T2190 T2189 arg1Of studied,also
R1895 T2141 T2139 arg2Of environment,maintain
R1896 T2141 T2140 arg1Of environment,an
R1897 T2141 T2142 arg1Of environment,that
R1898 T2141 T2143 arg1Of environment,is
R1899 T2141 T2144 arg1Of environment,permissive
R1900 T2144 T2143 arg2Of permissive,is
R1901 T2144 T2145 arg1Of permissive,for
R1902 T2192 T2190 arg2Of effects,studied
R1903 T2146 T2145 arg2Of transcription,for
R1904 T2147 T2149 arg1Of We,investigated
R1905 T2192 T2191 arg1Of effects,the
R1906 T2149 T2148 arg1Of investigated,therefore
R1907 T2149 T2158 arg1Of investigated,","
R1908 T2149 T2159 arg1Of investigated,on
R1909 T2192 T2193 arg1Of effects,of
R1910 T2151 T2149 arg2Of effects,investigated
R1911 T2151 T2150 arg1Of effects,the
R1912 T2151 T2152 arg1Of effects,of
R1913 T2192 T2197 arg1Of effects,on
R1914 T2155 T2152 arg2Of corticosteroid,of
R1915 T2155 T2153 arg1Of corticosteroid,a
R1916 T2155 T2154 arg1Of corticosteroid,synthetic
R1917 T2155 T2156 arg1Of corticosteroid,","
R1918 T2157 T2156 arg2Of FP,","
R1919 T2196 T2193 arg2Of therapy,of
R1920 T2161 T2160 arg1Of phosphorylation,GATA-3
R1921 T2161 T2162 arg1Of phosphorylation,and
R1922 T2162 T2159 arg2Of and,on
R1923 T2162 T2165 arg1Of and,in
R1924 T2162 T2175 arg1Of and,in
R1925 T2164 T2162 arg2Of translocation,and
R1926 T2164 T2163 arg1Of translocation,nuclear
R1927 T2165 T2174 arg1Of in,and
R1928 T2196 T2194 arg2Of therapy,inhaled
R1929 T2196 T2195 arg1Of therapy,fluticasone
R1930 T2170 T2165 arg2Of line,in
R1931 T2170 T2166 arg1Of line,a
R1932 T2170 T2167 arg1Of line,T
R1933 T2170 T2168 arg1Of line,lymphocyte
R1934 T2170 T2169 arg1Of line,cell
R1935 T2170 T2171 arg1Of line,(
R1936 T2172 T2171 arg2Of HuT-78,(
R1937 T2200 T2197 arg2Of localization,on
R1938 T2173 T2171 arg3Of ),(
R1939 T2175 T2174 arg2Of in,and
R1940 T2200 T2198 arg1Of localization,GATA-3
R1941 T2179 T2175 arg2Of cells,in
R1942 T2179 T2176 arg1Of cells,peripheral
R1943 T2179 T2177 arg1Of cells,blood
R1944 T2179 T2178 arg1Of cells,mononuclear
R1945 T2179 T2180 arg2Of cells,activated
R1946 T2180 T2187 arg1Of activated,vitro
R1947 T2200 T2199 arg1Of localization,subcellular
R1948 T2182 T2183 arg1Of anti-CD3,and
R1949 T2200 T2201 arg1Of localization,in
R1950 T2205 T2201 arg2Of cells,in
R1951 T2205 T2202 arg1Of cells,peripheral
R1952 T2205 T2203 arg1Of cells,blood
R1953 T2205 T2204 arg1Of cells,mononuclear
R1954 T2205 T2206 arg1Of cells,(
R1955 T2205 T2209 arg1Of cells,from
R1956 T2207 T2206 arg2Of PBMCs,(
R1957 T2208 T2206 arg3Of ),(
R1959 T2210 T2209 arg2Of patients,from
R1962 T2210 T2211 arg1Of patients,with
R1964 T2212 T2211 arg2Of asthma,with
R3148 T3675 T3676 arg1Of Participants,and
R3149 T3678 T3676 arg2Of Design,and
R3150 T3678 T3677 arg1Of Design,Study
R3151 T3679 T3680 arg1Of We,studied
R3152 T3680 T3701 arg1Of studied,","
R3153 T3680 T3708 arg1Of studied,[
R3154 T3681 T3680 arg2Of patients,studied
R3155 T3681 T3682 arg1Of patients,with
R3156 T3681 T3685 arg1Of patients,who
R3157 T3681 T3686 arg1Of patients,were
R3158 T3681 T3688 arg2Of patients,treated
R3159 T3684 T3682 arg2Of asthma,with
R3160 T3684 T3683 arg1Of asthma,mild
R3161 T3688 T3686 arg2Of treated,were
R3162 T3688 T3687 arg1Of treated,not
R3163 T3688 T3689 arg1Of treated,with
R3164 T3691 T3689 arg2Of corticosteroids,with
R3165 T3691 T3690 arg2Of corticosteroids,inhaled
R3166 T3691 T3692 arg1Of corticosteroids,who
R3167 T3691 T3693 arg1Of corticosteroids,had
R3168 T3691 T3694 arg1Of corticosteroids,been
R3169 T3691 T3695 arg2Of corticosteroids,included
R3170 T3695 T3693 arg2Of included,had
R3171 T3695 T3694 arg2Of included,been
R3172 T3695 T3696 arg1Of included,in
R3173 T3699 T3698 arg1Of reported,previously
R3174 T3700 T3696 arg2Of double-blind,in
R3175 T3700 T3697 arg1Of double-blind,a
R3176 T3700 T3699 arg1Of double-blind,reported
R3177 T3702 T3703 arg1Of placebo-controlled,","
R3178 T3704 T3703 arg2Of crossover,","
R3179 T3705 T3680 arg3Of study,studied
R3180 T3705 T3702 arg1Of study,placebo-controlled
R3181 T3705 T3704 arg1Of study,crossover
R3182 T3705 T3706 arg1Of study,with
R3183 T3707 T3706 arg2Of FP,with
R3184 T3709 T3708 arg2Of 34,[
R3185 T3710 T3708 arg3Of ],[
R3186 T3712 T3711 arg1Of patients,Seven
R3187 T3712 T3713 arg1Of patients,with
R3188 T3712 T3716 arg1Of patients,entered
R3189 T3712 T3720 arg1Of patients,were
R3190 T3712 T3721 arg2Of patients,randomized
R3191 T3712 T3723 arg1Of patients,receive
R3192 T3715 T3713 arg2Of asthma,with
R3193 T3715 T3714 arg1Of asthma,mild
R3194 T3716 T3719 arg1Of entered,and
R3195 T3718 T3716 arg2Of study,entered
R3196 T3718 T3717 arg1Of study,the
R3197 T3719 T3745 arg1Of and,and
R3198 T3721 T3719 arg2Of randomized,and
R3199 T3721 T3720 arg2Of randomized,were
R3200 T3723 T3721 arg3Of receive,randomized
R3201 T3723 T3722 arg1Of receive,to
R3202 T3723 T3740 arg1Of receive,via
R3203 T3726 T3724 arg1Of inhalation,a
R3204 T3726 T3725 arg1Of inhalation,single
R3205 T3726 T3727 arg1Of inhalation,of
R3206 T3726 T3735 arg1Of inhalation,or
R3207 T3728 T3727 arg2Of FP,of
R3208 T3728 T3729 arg1Of FP,(
R3209 T3730 T3731 arg1Of 100,and
R3210 T3732 T3731 arg2Of 500,and
R3211 T3733 T3729 arg2Of µg,(
R3212 T3733 T3730 arg1Of µg,100
R3213 T3733 T3732 arg1Of µg,500
R3214 T3734 T3729 arg3Of ),(
R3215 T3735 T3723 arg2Of or,receive
R3216 T3739 T3735 arg2Of control,or
R3217 T3739 T3736 arg1Of control,a
R3218 T3739 T3737 arg1Of control,matched
R3219 T3739 T3738 arg1Of control,placebo
R3220 T3743 T3740 arg2Of chamber,via
R3221 T3743 T3741 arg1Of chamber,a
R3222 T3743 T3742 arg1Of chamber,spacer
R3223 T3745 T3744 arg1Of and,","
R3224 T3748 T3746 arg1Of treatment,the
R3225 T3748 T3747 arg1Of treatment,other
R3226 T3748 T3749 arg1Of treatment,was
R3227 T3748 T3750 arg2Of treatment,given
R3228 T3750 T3745 arg2Of given,and
R3229 T3750 T3749 arg2Of given,was
R3230 T3750 T3751 arg1Of given,after
R3231 T3754 T3751 arg2Of period,after
R3232 T3754 T3752 arg1Of period,a
R3233 T3754 T3753 arg1Of period,wash-out
R3234 T3754 T3755 arg1Of period,of
R3235 T3758 T3756 arg1Of 6,at
R3236 T3758 T3757 arg1Of 6,least
R3237 T3759 T3755 arg2Of d,of
R3238 T3759 T3758 arg1Of d,6
R3239 T3760 T3761 arg1Of Blood,was
R3240 T3760 T3762 arg2Of Blood,taken
R3241 T3762 T3761 arg2Of taken,was
R3242 T3762 T3763 arg1Of taken,for
R3243 T3764 T3763 arg2Of preparation,for
R3244 T3764 T3765 arg1Of preparation,of
R3245 T3764 T3767 arg1Of preparation,at
R3246 T3766 T3765 arg2Of PBMCs,of
R3247 T3768 T3769 arg1Of 1,and
R3248 T3770 T3769 arg2Of 2,and
R3249 T3771 T3767 arg2Of h,at
R3250 T3771 T3768 arg1Of h,1
R3251 T3771 T3770 arg1Of h,2
R3252 T3771 T3772 arg1Of h,after
R3253 T3774 T3772 arg2Of administration,after
R3254 T3774 T3773 arg1Of administration,drug
R3255 T3776 T3775 arg1Of patients,All
R3256 T3776 T3777 arg1Of patients,gave
R3257 T3776 T3801 arg1Of patients,was
R3258 T3776 T3802 arg2Of patients,conducted
R3259 T3777 T3780 arg1Of gave,and
R3260 T3779 T3777 arg2Of consent,gave
R3261 T3779 T3778 arg2Of consent,informed
R3262 T3782 T3781 arg1Of study,the
R3263 T3782 T3783 arg1Of study,was
R3264 T3782 T3784 arg2Of study,approved
R3265 T3784 T3783 arg2Of approved,was
R3266 T3788 T3786 arg1Of Committee,the
R3267 T3788 T3787 arg1Of Committee,Ethics
R3268 T3788 T3789 arg1Of Committee,of
R3269 T3788 T3793 arg1Of Committee,and
R3270 T3792 T3789 arg2Of Brompton,of
R3271 T3792 T3790 arg1Of Brompton,the
R3272 T3792 T3791 arg1Of Brompton,Royal
R3273 T3793 T3784 arg1Of and,approved
R3274 T3793 T3785 arg2Of and,by
R3275 T3797 T3794 arg1Of Trust.,Harefield
R3276 T3797 T3795 arg1Of Trust.,Hospitals
R3277 T3797 T3796 arg1Of Trust.,NHS
R3278 T3800 T3793 arg2Of study,and
R3279 T3800 T3797 arg1Of study,Trust.
R3280 T3800 T3798 arg1Of study,The
R3281 T3800 T3799 arg1Of study,clinical
R3282 T3802 T3780 arg2Of conducted,and
R3283 T3802 T3783 modOf conducted,was
R3284 T3802 T3801 arg2Of conducted,was
R3285 T3802 T3803 arg1Of conducted,before
R3286 T3805 T3803 arg2Of requirement,before
R3287 T3805 T3804 arg1Of requirement,the
R3288 T3805 T3806 arg1Of requirement,for
R3289 T3809 T3806 arg2Of Registration,for
R3290 T3809 T3807 arg1Of Registration,Clinical
R3291 T3809 T3808 arg1Of Registration,Trial
R3431 T3981 T3982 arg1Of Antibodies,and
R3432 T3983 T3982 arg2Of Reagents,and
R3433 T3986 T3984 arg1Of antibodies,The
R3434 T3986 T3985 arg1Of antibodies,monoclonal
R3435 T3986 T3987 arg1Of antibodies,against
R3436 T3986 T3997 arg1Of antibodies,were
R3437 T3986 T3998 arg2Of antibodies,purchased
R3438 T3989 T3988 arg1Of CD3,human
R3439 T3989 T3990 arg1Of CD3,","
R3440 T3990 T3992 arg1Of ",",","
R3441 T3991 T3990 arg2Of CD28,","
R3442 T3992 T3995 arg1Of ",",and
R3443 T3993 T3992 arg2Of GR,","
R3444 T3995 T3987 arg2Of and,against
R3445 T3995 T3994 arg1Of and,","
R3446 T3996 T3995 arg2Of importin-α,and
R3447 T3998 T3997 arg2Of purchased,were
R3448 T3998 T3999 arg1Of purchased,from
R3449 T4001 T3999 arg2Of Biosciences,from
R3450 T4001 T4000 arg1Of Biosciences,BD
R3451 T4001 T4002 arg1Of Biosciences,(
R3452 T4003 T4002 arg2Of Oxford,(
R3453 T4003 T4004 arg1Of Oxford,","
R3454 T4006 T4004 arg2Of Kingdom,","
R3455 T4006 T4005 arg1Of Kingdom,United
R3456 T4007 T4002 arg3Of ),(
R3457 T4009 T4008 arg1Of antibodies,Rabbit
R3458 T4009 T4010 arg1Of antibodies,against
R3459 T4009 T4023 arg1Of antibodies,were
R3460 T4009 T4024 arg2Of antibodies,obtained
R3461 T4012 T4011 arg1Of GATA-3,human
R3462 T4012 T4013 arg1Of GATA-3,(
R3463 T4012 T4016 arg1Of GATA-3,and
R3464 T4014 T4013 arg2Of H-48,(
R3465 T4015 T4013 arg3Of ),(
R3466 T4016 T4010 arg2Of and,against
R3467 T4017 T4016 arg2Of GR,and
R3468 T4017 T4018 arg1Of GR,(
R3469 T4019 T4018 arg2Of E-20,(
R3470 T4019 T4020 arg1Of E-20,","
R3471 T4021 T4020 arg2Of sc-1003,","
R3472 T4022 T4018 arg3Of ),(
R3473 T4024 T4023 arg2Of obtained,were
R3474 T4024 T4025 arg1Of obtained,from
R3475 T4028 T4026 arg1Of Biotechnology,Santa
R3476 T4028 T4027 arg1Of Biotechnology,Cruz
R3477 T4028 T4029 arg1Of Biotechnology,(
R3478 T4028 T4038 arg1Of Biotechnology,","
R3479 T4031 T4030 arg1Of Cruz,Santa
R3480 T4031 T4032 arg1Of Cruz,","
R3481 T4032 T4034 arg1Of ",",","
R3482 T4033 T4032 arg2Of California,","
R3483 T4034 T4029 arg2Of ",",(
R3484 T4036 T4034 arg2Of States,","
R3485 T4036 T4035 arg1Of States,United
R3486 T4037 T4029 arg3Of ),(
R3487 T4038 T4046 arg1Of ",",and
R3488 T4041 T4038 arg2Of antibodies,","
R3489 T4041 T4039 arg1Of antibodies,polyclonal
R3490 T4041 T4040 arg1Of antibodies,rabbit
R3491 T4041 T4042 arg1Of antibodies,against
R3492 T4045 T4042 arg2Of kinase,against
R3493 T4045 T4043 arg1Of kinase,phospho-p38
R3494 T4045 T4044 arg1Of kinase,MAP
R3495 T4046 T4080 arg1Of and,and
R3496 T4047 T4046 arg2Of phospho-ATF-2,and
R3497 T4047 T4048 arg1Of phospho-ATF-2,from
R3498 T4051 T4049 arg1Of Technology,Cell
R3499 T4051 T4050 arg1Of Technology,Signaling
R3500 T4051 T4052 arg1Of Technology,(
R3501 T4051 T4061 arg1Of Technology,","
R3502 T4055 T4052 arg2Of Biolabs,(
R3503 T4055 T4053 arg1Of Biolabs,New
R3504 T4055 T4054 arg1Of Biolabs,England
R3505 T4055 T4056 arg1Of Biolabs,","
R3506 T4057 T4056 arg2Of Hertford,","
R3507 T4057 T4058 arg1Of Hertford,","
R3508 T4057 T4059 arg1Of Hertford,UK
R3509 T4060 T4052 arg3Of ),(
R3510 T4061 T4048 arg2Of ",",from
R3511 T4061 T4070 arg1Of ",",from
R3512 T4063 T4061 arg2Of antibody,","
R3513 T4063 T4062 arg1Of antibody,monoclonal
R3514 T4063 T4064 arg1Of antibody,against
R3515 T4065 T4064 arg2Of phosphoserine,against
R3516 T4065 T4066 arg1Of phosphoserine,(
R3517 T4068 T4066 arg2Of 4H4,(
R3518 T4068 T4067 arg1Of 4H4,clone
R3519 T4069 T4066 arg3Of ),(
R3520 T4073 T4070 arg2Of Products,from
R3521 T4073 T4071 arg1Of Products,Affiniti
R3522 T4073 T4072 arg1Of Products,Research
R3523 T4073 T4074 arg1Of Products,(
R3524 T4075 T4074 arg2Of Exeter,(
R3525 T4075 T4076 arg1Of Exeter,","
R3526 T4075 T4077 arg1Of Exeter,UK
R3527 T4078 T4074 arg3Of ),(
R3528 T4080 T4025 arg2Of and,from
R3529 T4080 T4079 arg1Of and,","
R3530 T4081 T4080 arg2Of antibodies,and
R3531 T4081 T4082 arg1Of antibodies,against
R3532 T4085 T4082 arg2Of TRITC,against
R3533 T4085 T4083 arg1Of TRITC,rabbit
R3534 T4085 T4084 arg1Of TRITC,IgG-conjugated
R3535 T4085 T4086 arg1Of TRITC,from
R3536 T4085 T4089 arg1Of TRITC,(
R3537 T4088 T4086 arg2Of Cytomation,from
R3538 T4088 T4087 arg1Of Cytomation,Dako
R3539 T4090 T4089 arg2Of Cambridge,(
R3540 T4090 T4091 arg1Of Cambridge,","
R3541 T4090 T4092 arg1Of Cambridge,UK
R3542 T4093 T4089 arg3Of ),(
R3543 T4096 T4094 arg1Of antibody,The
R3544 T4096 T4095 arg1Of antibody,anti-GR
R3545 T4096 T4097 arg1Of antibody,(
R3546 T4096 T4101 arg1Of antibody,from
R3547 T4096 T4110 arg1Of antibody,was
R3548 T4096 T4111 arg2Of antibody,used
R3549 T4098 T4097 arg2Of Clone,(
R3550 T4098 T4099 arg1Of Clone,41
R3551 T4100 T4097 arg3Of ),(
R3552 T4104 T4101 arg2Of Laboratories,from
R3553 T4104 T4102 arg1Of Laboratories,BD
R3554 T4104 T4103 arg1Of Laboratories,Transduction
R3555 T4104 T4105 arg1Of Laboratories,(
R3556 T4106 T4105 arg2Of Oxford,(
R3557 T4106 T4107 arg1Of Oxford,","
R3558 T4106 T4108 arg1Of Oxford,UK
R3559 T4109 T4105 arg3Of ),(
R3560 T4111 T4110 arg2Of used,was
R3561 T4111 T4112 arg1Of used,for
R3562 T4115 T4112 arg2Of analysis,for
R3563 T4115 T4113 arg1Of analysis,Western
R3564 T4115 T4114 arg1Of analysis,blot
R3565 T4118 T4116 arg1Of reagents,All
R3566 T4118 T4117 arg1Of reagents,other
R3567 T4118 T4119 arg1Of reagents,were
R3568 T4118 T4120 arg2Of reagents,purchased
R3569 T4120 T4119 arg2Of purchased,were
R3570 T4120 T4121 arg1Of purchased,from
R3571 T4122 T4121 arg2Of Sigma,from
R3572 T4122 T4123 arg1Of Sigma,(
R3573 T4124 T4123 arg2Of Poole,(
R3574 T4124 T4125 arg1Of Poole,","
R3575 T4126 T4125 arg2Of UK,","
R3576 T4127 T4123 arg3Of ),(
R3731 T4355 T4354 arg1Of Culture,Cell
R3732 T4355 T4356 arg1Of Culture,and
R3733 T4358 T4356 arg2Of Isolation,and
R3734 T4358 T4357 arg1Of Isolation,PBMC
R3735 T4363 T4359 arg1Of line,A
R3736 T4363 T4360 arg1Of line,human
R3737 T4363 T4361 arg1Of line,T
R3738 T4363 T4362 arg1Of line,cell
R3739 T4363 T4364 arg1Of line,(
R3740 T4363 T4367 arg1Of line,was
R3741 T4363 T4368 arg2Of line,purchased
R3742 T4365 T4364 arg2Of HuT-78,(
R3743 T4366 T4364 arg3Of ),(
R3744 T4368 T4367 arg2Of purchased,was
R3745 T4368 T4369 arg1Of purchased,from
R3746 T4372 T4370 arg1Of Collection,ECACC
R3747 T4372 T4371 arg1Of Collection,European
R3748 T4372 T4373 arg1Of Collection,of
R3749 T4372 T4376 arg1Of Collection,(
R3750 T4372 T4381 arg1Of Collection,were
R3751 T4372 T4382 arg2Of Collection,cultured
R3752 T4375 T4373 arg2Of Culture,of
R3753 T4375 T4374 arg1Of Culture,Cell
R3754 T4377 T4376 arg2Of Wiltshire,(
R3755 T4377 T4378 arg1Of Wiltshire,","
R3756 T4377 T4379 arg1Of Wiltshire,UK
R3757 T4380 T4376 arg3Of ),(
R3758 T4382 T4367 modOf cultured,was
R3759 T4382 T4381 arg2Of cultured,were
R3760 T4382 T4383 arg1Of cultured,as
R3761 T4385 T4384 arg1Of described,previously
R3762 T4387 T4383 arg2Of 12,as
R3763 T4387 T4385 arg1Of 12,described
R3764 T4387 T4386 arg2Of 12,[
R3765 T4388 T4386 arg3Of ],[
R3766 T4389 T4390 arg1Of PBMCs,were
R3767 T4389 T4391 arg2Of PBMCs,isolated
R3768 T4391 T4390 arg2Of isolated,were
R3769 T4391 T4392 arg1Of isolated,by
R3770 T4391 T4395 arg1Of isolated,over
R3771 T4394 T4392 arg2Of centrifugation,by
R3772 T4394 T4393 arg1Of centrifugation,density
R3773 T4396 T4395 arg2Of Ficoll-Hypaque,over
R3774 T4396 T4397 arg1Of Ficoll-Hypaque,(
R3775 T4396 T4410 arg1Of Ficoll-Hypaque,as
R3776 T4398 T4399 arg1Of density,","
R3777 T4398 T4402 arg1Of density,;
R3778 T4401 T4399 arg2Of g/ml,","
R3779 T4401 T4400 arg1Of g/ml,1.077
R3780 T4402 T4397 arg2Of ;,(
R3781 T4402 T4407 arg1Of ;,","
R3782 T4402 T4408 arg1Of ;,UK
R3783 T4404 T4402 arg2Of Biosciences,;
R3784 T4404 T4403 arg1Of Biosciences,Amersham
R3785 T4404 T4405 arg1Of Biosciences,","
R3786 T4406 T4405 arg2Of Amersham,","
R3787 T4409 T4397 arg3Of ),(
R3788 T4412 T4411 arg1Of described,previously
R3789 T4414 T4410 arg2Of 34,as
R3790 T4414 T4412 arg1Of 34,described
R3791 T4414 T4413 arg2Of 34,[
R3792 T4415 T4413 arg3Of ],[
R3793 T4416 T4417 arg1Of Cells,were
R3794 T4416 T4418 arg2Of Cells,stimulated
R3795 T4418 T4417 arg2Of stimulated,were
R3796 T4418 T4419 arg1Of stimulated,with
R3797 T4418 T4426 arg1Of stimulated,for
R3798 T4420 T4419 arg2Of anti-CD3/CD28,with
R3799 T4420 T4421 arg1Of anti-CD3/CD28,(
R3800 T4423 T4421 arg2Of µg/ml,(
R3801 T4423 T4422 arg1Of µg/ml,1
R3802 T4423 T4424 arg1Of µg/ml,each
R3803 T4425 T4421 arg3Of ),(
R3804 T4428 T4426 arg2Of h,for
R3805 T4428 T4427 arg1Of h,1
R3806 T4428 T4429 arg1Of h,at
R3807 T4428 T4431 modOf h,to
R3808 T4428 T4443 arg1Of h,(
R3809 T4430 T4429 arg2Of 37°C,at
R3810 T4432 T4431 arg1Of stimulate,to
R3811 T4435 T4432 arg2Of release,stimulate
R3812 T4435 T4433 arg1Of release,Th2
R3813 T4435 T4434 arg1Of release,cytokine
R3814 T4435 T4436 arg1Of release,in
R3815 T4435 T4441 arg1Of release,of
R3816 T4438 T4439 arg1Of presence,or
R3817 T4439 T4436 arg2Of or,in
R3818 T4439 T4437 arg1Of or,the
R3819 T4440 T4439 arg2Of absence,or
R3820 T4442 T4441 arg2Of FP,of
R3821 T4444 T4443 arg2Of 10−12,(
R3822 T4444 T4445 arg1Of 10−12,to
R3823 T4446 T4445 arg2Of 10−8M,to
R3824 T4447 T4443 arg3Of ),(
R3825 T4448 T4449 arg1Of Cytospins,were
R3826 T4448 T4450 arg2Of Cytospins,prepared
R3827 T4450 T4449 arg2Of prepared,were
R3828 T4450 T4451 arg1Of prepared,and
R3829 T4453 T4452 arg1Of localization,GATA-3
R3830 T4453 T4454 arg1Of localization,determined
R3831 T4454 T4451 arg2Of determined,and
R3832 T4457 T4454 arg2Of microscopy,determined
R3833 T4457 T4455 arg2Of microscopy,by
R3834 T4457 T4456 arg1Of microscopy,confocal
R3835 T4457 T4458 arg1Of microscopy,as
R3836 T4460 T4459 arg1Of described,previously
R3837 T4462 T4458 arg2Of 12,as
R3838 T4462 T4460 arg1Of 12,described
R3839 T4462 T4461 arg2Of 12,[
R3840 T4463 T4461 arg3Of ],[
R3969 T4624 T4622 arg1Of PCR,Reverse
R3970 T4624 T4623 arg1Of PCR,Transcription
R3971 T4626 T4625 arg1Of RNA,Total
R3972 T4626 T4627 arg1Of RNA,was
R3973 T4626 T4628 arg2Of RNA,extracted
R3975 T4628 T4627 arg2Of extracted,was
R3979 T4634 T4632 arg2Of kit,(
R3980 T4634 T4633 arg1Of kit,RNeasy
R3981 T4634 T4635 arg1Of kit,;
R3982 T4636 T4635 arg2Of Qiagen,;
R3983 T4636 T4637 arg1Of Qiagen,","
R3984 T4638 T4637 arg2Of Crawley,","
R3985 T4638 T4639 arg1Of Crawley,","
R3986 T4640 T4639 arg2Of UK,","
R3987 T4641 T4632 arg3Of ),(
R3988 T4644 T4642 arg2Of purification,During
R3989 T4644 T4643 arg1Of purification,RNA
R3990 T4647 T4646 arg1Of DNA,genomic
R3991 T4647 T4648 arg1Of DNA,was
R3992 T4647 T4649 arg2Of DNA,digested
R3993 T4649 T4642 arg1Of digested,During
R3994 T4649 T4645 arg1Of digested,","
R3995 T4649 T4648 arg2Of digested,was
R3996 T4649 T4650 arg1Of digested,with
R3997 T4652 T4650 arg2Of DNase,with
R3998 T4652 T4651 arg1Of DNase,RNase-free
R3999 T4652 T4653 arg1Of DNase,(
R4000 T4655 T4653 arg2Of Biosciences,(
R4001 T4655 T4654 arg1Of Biosciences,Amersham
R4002 T4656 T4653 arg3Of ),(
R4003 T4660 T4659 arg1Of µg,0.5
R4004 T4660 T4661 arg1Of µg,of
R4005 T4660 T4664 arg1Of µg,was
R4006 T4660 T4665 arg2Of µg,reversed
R4007 T4663 T4661 arg2Of RNA,of
R4008 T4663 T4662 arg1Of RNA,total
R4009 T4665 T4657 arg1Of reversed,Next
R4010 T4665 T4658 arg1Of reversed,","
R4011 T4665 T4664 arg2Of reversed,was
R4012 T4665 T4666 modOf reversed,transcribed
R4013 T4665 T4667 modOf reversed,using
R4014 T4665 T4673 arg1Of reversed,(
R4015 T4672 T4667 arg2Of RT,using
R4016 T4672 T4668 arg1Of RT,the
R4017 T4672 T4669 arg1Of RT,avian
R4018 T4672 T4670 arg1Of RT,myeloblastosis
R4019 T4672 T4671 arg1Of RT,virus
R4020 T4674 T4675 arg1Of Promega,","
R4021 T4675 T4673 arg2Of ",",(
R4022 T4675 T4677 arg1Of ",",","
R4023 T4676 T4675 arg2Of Southampton,","
R4024 T4678 T4677 arg2Of UK,","
R4025 T4679 T4673 arg3Of ),(
R4026 T4682 T4680 arg2Of quantification,For
R4027 T4682 T4681 arg1Of quantification,relative
R4028 T4684 T4685 arg1Of RT-PCR,was
R4029 T4684 T4686 arg2Of RT-PCR,carried
R4030 T4686 T4680 arg1Of carried,For
R4031 T4686 T4683 arg1Of carried,","
R4032 T4686 T4685 arg2Of carried,was
R4033 T4686 T4687 arg1Of carried,out
R4034 T4686 T4688 modOf carried,using
R4035 T4690 T4688 arg2Of probes,using
R4036 T4690 T4689 arg1Of probes,cDNA
R4037 T4691 T4692 arg1Of Primers,for
R4038 T4691 T4694 arg1Of Primers,were
R4039 T4691 T4695 arg1Of Primers,from
R4040 T4693 T4692 arg2Of IL-4,for
R4041 T4694 T4697 arg1Of were,(
R4042 T4695 T4694 arg2Of from,were
R4043 T4696 T4695 arg2Of Sigma-Genosys,from
R4044 T4698 T4697 arg2Of Cambridge,(
R4045 T4698 T4699 arg1Of Cambridge,","
R4046 T4698 T4700 arg1Of Cambridge,UK
R4047 T4701 T4697 arg3Of ),(
R4048 T4702 T4703 arg1Of Sequences,of
R4049 T4702 T4706 arg1Of Sequences,are
R4050 T4702 T4708 arg1Of Sequences,follows
R4051 T4704 T4703 arg2Of GADPH,of
R4052 T4704 T4705 arg2Of GADPH,used
R4053 T4706 T4707 arg1Of are,as
R4054 T4708 T4707 arg2Of follows,as
R4055 T4708 T4709 arg1Of follows,:
R4056 T4711 T4708 arg2Of 5′-CCACCCATGGCAAATTCCATGGC,follows
R4057 T4711 T4710 arg1Of 5′-CCACCCATGGCAAATTCCATGGC,forward
R4058 T4711 T4712 arg1Of 5′-CCACCCATGGCAAATTCCATGGC,","
R4059 T4714 T4712 arg2Of 3′-TCTAGACGGCAGGTCAGGTCCAC,","
R4060 T4714 T4713 arg1Of 3′-TCTAGACGGCAGGTCAGGTCCAC,reverse
R4166 T4854 T4853 arg1Of Fractionation,Cell
R4167 T4854 T4855 arg1Of Fractionation,","
R4168 T4855 T4858 arg1Of ",",and
R4169 T4856 T4855 arg2Of Immunoprecipitation,","
R4170 T4858 T4857 arg1Of and,","
R4171 T4860 T4859 arg1Of Blot,Western
R4172 T4861 T4858 arg2Of Analysis,and
R4173 T4861 T4860 arg1Of Analysis,Blot
R4174 T4862 T4863 arg1Of Nuclear,and
R4175 T4864 T4863 arg2Of cytoplasmic,and
R4176 T4865 T4862 arg1Of fractions,Nuclear
R4177 T4865 T4864 arg1Of fractions,cytoplasmic
R4178 T4865 T4866 arg1Of fractions,were
R4179 T4865 T4867 arg2Of fractions,prepared
R4180 T4867 T4866 arg2Of prepared,were
R4181 T4867 T4868 arg1Of prepared,as
R4182 T4870 T4869 arg1Of described,previously
R4183 T4872 T4868 arg2Of 35,as
R4184 T4872 T4870 arg1Of 35,described
R4185 T4872 T4871 arg2Of 35,[
R4186 T4873 T4871 arg3Of ],[
R4187 T4876 T4874 arg1Of lysates,Whole
R4188 T4876 T4875 arg1Of lysates,cell
R4189 T4876 T4877 arg1Of lysates,were
R4190 T4876 T4878 arg2Of lysates,prepared
R4191 T4878 T4877 arg2Of prepared,were
R4192 T4878 T4879 arg1Of prepared,in
R4193 T4882 T4879 arg2Of buffer,in
R4194 T4882 T4880 arg1Of buffer,NP-40
R4195 T4882 T4881 arg1Of buffer,lysis
R4196 T4882 T4883 arg1Of buffer,(
R4197 T4882 T4901 arg1Of buffer,in
R4198 T4884 T4885 arg1Of 0.5,%
R4199 T4887 T4884 arg1Of P-40,0.5
R4200 T4887 T4886 arg1Of P-40,Nonidet
R4201 T4887 T4888 arg1Of P-40,","
R4202 T4888 T4896 arg1Of ",",","
R4203 T4889 T4890 arg1Of 20,mM
R4204 T4891 T4888 arg2Of Tris-HCl,","
R4205 T4891 T4889 arg1Of Tris-HCl,20
R4206 T4891 T4892 arg1Of Tris-HCl,[
R4207 T4893 T4892 arg2Of pH,[
R4208 T4893 T4894 arg1Of pH,7.5
R4209 T4895 T4892 arg3Of ],[
R4210 T4896 T4883 arg2Of ",",(
R4211 T4897 T4898 arg1Of 150,mM
R4212 T4899 T4896 arg2Of NaCl,","
R4213 T4899 T4897 arg1Of NaCl,150
R4214 T4900 T4883 arg3Of ),(
R4215 T4903 T4901 arg2Of presence,in
R4216 T4903 T4902 arg1Of presence,the
R4217 T4903 T4904 arg1Of presence,of
R4218 T4908 T4904 arg2Of inhibitor,of
R4219 T4908 T4905 arg1Of inhibitor,complete
R4220 T4908 T4906 arg1Of inhibitor,protease
R4221 T4908 T4907 arg1Of inhibitor,cocktail
R4222 T4909 T4910 arg1Of Lysates,were
R4223 T4909 T4911 arg2Of Lysates,centrifuged
R4224 T4909 T4925 arg1Of Lysates,remove
R4225 T4911 T4910 arg2Of centrifuged,were
R4226 T4911 T4912 arg1Of centrifuged,at
R4227 T4911 T4914 arg1Of centrifuged,for
R4228 T4911 T4917 arg1Of centrifuged,at
R4229 T4911 T4920 arg1Of centrifuged,in
R4230 T4911 T4924 modOf centrifuged,to
R4231 T4913 T4912 arg2Of 4°C,at
R4232 T4916 T4914 arg2Of min,for
R4233 T4916 T4915 arg1Of min,10
R4234 T4919 T4917 arg2Of rpm,at
R4235 T4919 T4918 arg1Of rpm,"12,000"
R4236 T4923 T4920 arg2Of microcentrifuge,in
R4237 T4923 T4921 arg1Of microcentrifuge,an
R4238 T4923 T4922 arg1Of microcentrifuge,Eppendorf
R4239 T4925 T4924 arg1Of remove,to
R4240 T4927 T4925 arg2Of debris,remove
R4241 T4927 T4926 arg1Of debris,cellular
R4242 T4928 T4929 arg1Of Samples,were
R4243 T4928 T4931 arg2Of Samples,immunoprecipitated
R4244 T4931 T4929 arg2Of immunoprecipitated,were
R4245 T4931 T4930 arg1Of immunoprecipitated,then
R4246 T4931 T4932 arg1Of immunoprecipitated,with
R4247 T4935 T4932 arg2Of µl,with
R4248 T4935 T4933 arg1Of µl,either
R4249 T4935 T4934 arg1Of µl,10
R4250 T4935 T4936 arg1Of µl,of
R4251 T4935 T4942 arg1Of µl,using
R4252 T4935 T4952 arg1Of µl,using
R4253 T4935 T4958 arg1Of µl,(
R4254 T4937 T4936 arg2Of antibody,of
R4255 T4937 T4938 arg1Of antibody,against
R4256 T4939 T4940 arg1Of GATA-3,or
R4257 T4940 T4938 arg2Of or,against
R4258 T4941 T4940 arg2Of importin-α,or
R4259 T4942 T4946 arg1Of using,in
R4260 T4942 T4952 modOf using,using
R4261 T4945 T4942 arg2Of slurry,using
R4262 T4945 T4943 arg1Of slurry,A/G
R4263 T4945 T4944 arg2Of slurry,agarose
R4264 T4948 T4946 arg2Of presence,in
R4265 T4948 T4947 arg1Of presence,the
R4266 T4948 T4949 arg1Of presence,of
R4267 T4951 T4949 arg2Of inhibitor,of
R4268 T4951 T4950 arg1Of inhibitor,protease
R4269 T4954 T4955 arg1Of Catch,and
R4270 T4956 T4955 arg2Of Release,and
R4271 T4957 T4952 arg2Of methodology,using
R4272 T4957 T4953 arg1Of methodology,the
R4273 T4957 T4954 arg1Of methodology,Catch
R4274 T4957 T4956 arg1Of methodology,Release
R4275 T4960 T4959 arg1Of Biotechnology,Upstate
R4276 T4960 T4961 arg1Of Biotechnology,","
R4277 T4961 T4964 arg1Of ",",","
R4278 T4963 T4961 arg2Of Placid,","
R4279 T4963 T4962 arg1Of Placid,Lake
R4280 T4964 T4958 arg2Of ",",(
R4281 T4964 T4967 arg1Of ",",","
R4282 T4964 T4968 arg1Of ",",USA
R4283 T4966 T4964 arg2Of York,","
R4284 T4966 T4965 arg1Of York,New
R4285 T4969 T4958 arg3Of ),(
R4286 T4972 T4970 arg1Of analysis,Western
R4287 T4972 T4971 arg1Of analysis,blot
R4288 T4972 T4973 arg1Of analysis,was
R4289 T4972 T4974 arg2Of analysis,performed
R4290 T4974 T4973 arg2Of performed,was
R4291 T4975 T4974 arg3Of using,performed
R4292 T4976 T4975 arg2Of anti-GATA-3,using
R4293 T4976 T4977 arg1Of anti-GATA-3,","
R4294 T4978 T4979 arg1Of anti-importin-α,","
R4295 T4979 T4981 arg1Of ",",","
R4296 T4980 T4979 arg2Of anti-GR,","
R4297 T4982 T4981 arg2Of anti-p-p38,","
R4298 T4984 T4978 arg1Of kinase,anti-importin-α
R4299 T4984 T4980 arg1Of kinase,anti-GR
R4300 T4984 T4982 arg1Of kinase,anti-p-p38
R4301 T4984 T4983 arg1Of kinase,MAP
R4302 T4984 T4985 arg1Of kinase,","
R4303 T4985 T4988 arg1Of ",",and
R4304 T4986 T4985 arg2Of anti-p-ATF-2,","
R4305 T4988 T4977 arg2Of and,","
R4306 T4988 T4987 arg1Of and,","
R4307 T4989 T4988 arg2Of anti-p-serine,and
R4308 T4991 T4990 arg1Of proteins,Immunoreactive
R4309 T4991 T4992 arg1Of proteins,were
R4310 T4991 T4993 arg2Of proteins,detected
R4311 T4993 T4992 arg2Of detected,were
R4312 T4994 T4993 arg3Of using,detected
R4313 T4999 T4994 arg2Of kit,using
R4314 T4999 T4995 arg1Of kit,an
R4315 T4999 T4996 arg2Of kit,enhanced
R4316 T4999 T4997 arg1Of kit,chemiluminescence
R4317 T4999 T4998 arg1Of kit,ECL
R4318 T4999 T5000 arg1Of kit,(
R4319 T5002 T5000 arg2Of Biosciences,(
R4320 T5002 T5001 arg1Of Biosciences,Amersham
R4321 T5003 T5000 arg3Of ),(
R4483 T5207 T5206 arg1Of Immunoprecipitation,Chromatin
R4484 T5209 T5208 arg1Of immunoprecipitation,Chromatin
R4485 T5209 T5210 arg1Of immunoprecipitation,(
R4486 T5209 T5213 arg1Of immunoprecipitation,was
R4487 T5209 T5214 arg2Of immunoprecipitation,performed
R4488 T5211 T5210 arg2Of IP,(
R4489 T5212 T5210 arg3Of ),(
R4490 T5214 T5213 arg2Of performed,was
R4491 T5214 T5215 arg1Of performed,as
R4492 T5214 T5239 arg1Of performed,as
R4493 T5214 T5248 arg1Of performed,overnight
R4494 T5217 T5216 arg1Of described,previously
R4495 T5219 T5215 arg2Of 12,as
R4496 T5219 T5217 arg1Of 12,described
R4497 T5219 T5218 arg2Of 12,[
R4498 T5219 T5221 arg1Of 12,in
R4499 T5219 T5224 arg1Of 12,with
R4500 T5220 T5218 arg3Of ],[
R4501 T5223 T5221 arg2Of T-cells,in
R4502 T5223 T5222 arg1Of T-cells,HuT-78
R4503 T5226 T5224 arg2Of µg,with
R4504 T5226 T5225 arg1Of µg,2
R4505 T5226 T5227 arg1Of µg,of
R4506 T5228 T5229 arg1Of anti-GATA-3,(
R4507 T5228 T5235 arg1Of anti-GATA-3,or
R4508 T5232 T5229 arg2Of Biotechnology,(
R4509 T5232 T5230 arg1Of Biotechnology,Santa
R4510 T5232 T5231 arg1Of Biotechnology,Cruz
R4511 T5233 T5229 arg3Of ),(
R4512 T5235 T5227 arg2Of or,of
R4513 T5235 T5234 arg1Of or,","
R4514 T5238 T5235 arg2Of G,or
R4515 T5238 T5236 arg1Of G,isotypic
R4516 T5238 T5237 arg1Of G,immunoglobulin
R4517 T5242 T5239 arg2Of control,as
R4518 T5242 T5240 arg1Of control,a
R4519 T5242 T5241 arg1Of control,non-specific
R4520 T5242 T5243 arg1Of control,(
R4521 T5246 T5243 arg2Of Biotechnology,(
R4522 T5246 T5244 arg1Of Biotechnology,Santa
R4523 T5246 T5245 arg1Of Biotechnology,Cruz
R4524 T5247 T5243 arg3Of ),(
R4525 T5251 T5250 arg1Of Promoter,4°C.
R4526 T5252 T5251 arg1Of sequences,Promoter
R4527 T5252 T5253 arg1Of sequences,were
R4528 T5252 T5254 arg2Of sequences,detected
R4529 T5252 T5271 arg1Of sequences,reverse
R4530 T5254 T5253 arg2Of detected,were
R4531 T5254 T5255 arg1Of detected,with
R4532 T5254 T5270 arg1Of detected,and
R4533 T5257 T5255 arg2Of primers,with
R4534 T5257 T5256 arg1Of primers,PCR
R4535 T5257 T5258 arg1Of primers,for
R4536 T5261 T5259 arg1Of promoter,the
R4537 T5261 T5260 arg1Of promoter,IL-5
R4538 T5261 T5262 arg1Of promoter,(
R4539 T5261 T5267 arg1Of promoter,:
R4540 T5265 T5262 arg2Of +4,(
R4541 T5265 T5263 arg1Of +4,−445
R4542 T5265 T5264 arg1Of +4,to
R4543 T5266 T5262 arg3Of ),(
R4544 T5269 T5258 arg2Of 5′-TTAATCTAGCCACAGTCATAG-3′,for
R4545 T5269 T5261 arg1Of 5′-TTAATCTAGCCACAGTCATAG-3′,promoter
R4546 T5269 T5268 arg1Of 5′-TTAATCTAGCCACAGTCATAG-3′,forward
R4547 T5270 T5213 modOf and,was
R4548 T5270 T5249 arg1Of and,at
R4549 T5270 T5272 arg1Of and,:
R4550 T5271 T5270 arg2Of reverse,and
R4551 T5274 T5275 arg1Of PCR,was
R4552 T5274 T5276 arg2Of PCR,performed
R4553 T5276 T5275 arg2Of performed,was
R4554 T5277 T5276 arg3Of using,performed
R4555 T5280 T5279 arg1Of Omnigene,Hybaid
R4556 T5282 T5277 arg2Of cycler,using
R4557 T5282 T5278 arg1Of cycler,a
R4558 T5282 T5280 arg1Of cycler,Omnigene
R4559 T5282 T5281 arg1Of cycler,thermal
R4560 T5282 T5283 arg1Of cycler,(
R4561 T5282 T5290 arg1Of cycler,with
R4562 T5284 T5285 arg1Of Hybaid,","
R4563 T5285 T5283 arg2Of ",",(
R4564 T5285 T5287 arg1Of ",",","
R4565 T5286 T5285 arg2Of Ashford,","
R4566 T5288 T5287 arg2Of UK,","
R4567 T5289 T5283 arg3Of ),(
R4568 T5292 T5290 arg2Of parameters,with
R4569 T5292 T5291 arg1Of parameters,cycling
R4570 T5292 T5293 arg1Of parameters,of
R4571 T5292 T5301 arg1Of parameters,at
R4572 T5294 T5295 arg1Of 72°C,for
R4573 T5294 T5298 arg1Of 72°C,","
R4574 T5297 T5295 arg2Of min,for
R4575 T5297 T5296 arg1Of min,10
R4576 T5298 T5293 arg2Of ",",of
R4577 T5300 T5298 arg2Of cycles,","
R4578 T5300 T5299 arg1Of cycles,35
R4579 T5302 T5301 arg2Of 94°C,at
R4580 T5302 T5303 arg1Of 94°C,for
R4581 T5305 T5304 arg1Of s,45
R4582 T5305 T5306 arg1Of s,","
R4583 T5306 T5311 arg1Of ",",","
R4584 T5307 T5306 arg2Of 52°C,","
R4585 T5307 T5308 arg1Of 52°C,for
R4586 T5310 T5308 arg2Of s,for
R4587 T5310 T5309 arg1Of s,45
R4588 T5311 T5303 arg2Of ",",for
R4589 T5311 T5313 arg1Of ",",for
R4590 T5312 T5311 arg2Of 72°C,","
R4591 T5315 T5313 arg2Of s,for
R4592 T5315 T5314 arg1Of s,45
R4724 T5499 T5500 arg1Of GR-GATA-3,In
R4725 T5499 T5504 arg1Of GR-GATA-3,for
R4726 T5503 T5500 arg2Of Assay,In
R4727 T5503 T5501 arg1Of Assay,Vitro
R4728 T5503 T5502 arg1Of Assay,Competition
R4729 T5505 T5504 arg2Of Importin-α,for
R4730 T5505 T5506 arg1Of Importin-α,(
R4731 T5508 T5506 arg2Of ELISA,(
R4732 T5508 T5507 arg1Of ELISA,Far-Western
R4733 T5509 T5506 arg3Of ),(
R4734 T5513 T5510 arg2Of anti-importin-α,Immunoprecipitated
R4735 T5513 T5511 arg1Of anti-importin-α,importin-α
R4736 T5513 T5512 arg2Of anti-importin-α,(
R4737 T5513 T5514 arg1Of anti-importin-α,","
R4738 T5513 T5519 arg1Of anti-importin-α,from
R4739 T5513 T5522 arg1Of anti-importin-α,was
R4740 T5513 T5523 arg2Of anti-importin-α,separated
R4741 T5513 T5527 arg2Of anti-importin-α,purified
R4742 T5517 T5514 arg2Of Biotechnology,","
R4743 T5517 T5515 arg1Of Biotechnology,Santa
R4744 T5517 T5516 arg1Of Biotechnology,Cruz
R4745 T5518 T5512 arg3Of ),(
R4746 T5521 T5519 arg2Of cells,from
R4747 T5521 T5520 arg1Of cells,HuT-78
R4748 T5523 T5526 arg1Of separated,and
R4749 T5525 T5523 arg1Of SDS-PAGE,separated
R4750 T5525 T5524 arg2Of SDS-PAGE,by
R4751 T5526 T5522 arg2Of and,was
R4752 T5527 T5526 arg2Of purified,and
R4753 T5527 T5528 arg1Of purified,from
R4754 T5527 T5534 arg1Of purified,[
R4755 T5531 T5528 arg2Of gel,from
R4756 T5531 T5529 arg1Of gel,the
R4757 T5531 T5530 arg2Of gel,excised
R4758 T5533 T5527 arg1Of electroelution,purified
R4759 T5533 T5532 arg2Of electroelution,by
R4760 T5535 T5534 arg2Of 36,[
R4761 T5536 T5534 arg3Of ],[
R4762 T5539 T5540 arg1Of GATA-3,was
R4763 T5539 T5541 arg2Of GATA-3,isolated
R4764 T5541 T5537 arg1Of isolated,Similarly
R4765 T5541 T5538 arg1Of isolated,","
R4766 T5541 T5540 arg2Of isolated,was
R4767 T5541 T5542 arg1Of isolated,from
R4768 T5541 T5554 arg1Of isolated,and
R4769 T5545 T5543 arg1Of cells,nonstimulated
R4770 T5545 T5544 arg1Of cells,HuT-78
R4771 T5545 T5546 arg1Of cells,or
R4772 T5546 T5542 arg2Of or,from
R4773 T5547 T5546 arg2Of cells,or
R4774 T5547 T5548 arg2Of cells,stimulated
R4775 T5548 T5549 arg1Of stimulated,for
R4776 T5551 T5549 arg2Of min,for
R4777 T5551 T5550 arg1Of min,30
R4778 T5551 T5552 arg1Of min,with
R4779 T5553 T5552 arg2Of anti-CD3/CD28,with
R4780 T5555 T5556 arg1Of GR,was
R4781 T5555 T5557 arg2Of GR,isolated
R4782 T5557 T5554 arg2Of isolated,and
R4783 T5557 T5556 arg2Of isolated,was
R4784 T5557 T5558 arg1Of isolated,from
R4785 T5559 T5560 arg1Of FP,(
R4786 T5562 T5560 arg2Of M,(
R4787 T5562 T5561 arg1Of M,10−8
R4788 T5562 T5563 arg1Of M,","
R4789 T5565 T5563 arg2Of min,","
R4790 T5565 T5564 arg1Of min,30
R4791 T5566 T5560 arg3Of ),(
R4792 T5569 T5558 arg2Of cells,from
R4793 T5569 T5559 arg1Of cells,FP
R4794 T5569 T5567 arg1Of cells,stimulated
R4795 T5569 T5568 arg1Of cells,HuT-78
R4796 T5571 T5570 arg1Of proteins,These
R4797 T5571 T5572 arg1Of proteins,were
R4798 T5571 T5574 arg2Of proteins,refolded
R4799 T5574 T5572 arg2Of refolded,were
R4800 T5574 T5573 arg1Of refolded,subsequently
R4801 T5574 T5575 arg1Of refolded,in
R4802 T5577 T5575 arg2Of solution,in
R4803 T5577 T5576 arg1Of solution,glycine
R4804 T5579 T5578 arg1Of µl,100
R4805 T5579 T5580 arg1Of µl,of
R4806 T5579 T5583 arg1Of µl,(
R4807 T5579 T5589 arg1Of µl,was
R4808 T5579 T5590 arg2Of µl,added
R4809 T5582 T5580 arg2Of solution,of
R4810 T5582 T5581 arg1Of solution,importin-α
R4811 T5585 T5583 arg2Of ng/ml,(
R4812 T5585 T5584 arg1Of ng/ml,100
R4813 T5585 T5586 arg1Of ng/ml,in
R4814 T5587 T5586 arg2Of TBS,in
R4815 T5588 T5583 arg3Of ),(
R4816 T5590 T5589 arg2Of added,was
R4817 T5590 T5591 arg1Of added,to
R4818 T5593 T5591 arg2Of plates,to
R4819 T5593 T5592 arg1Of plates,96-well
R4820 T5593 T5594 arg2Of plates,coated
R4821 T5594 T5595 arg1Of coated,with
R4822 T5598 T5595 arg2Of antibody,with
R4823 T5598 T5596 arg1Of antibody,goat
R4824 T5598 T5597 arg1Of antibody,anti-importin-α
R4825 T5602 T5599 arg2Of incubation,After
R4826 T5602 T5600 arg1Of incubation,1
R4827 T5602 T5601 arg1Of incubation,h
R4828 T5604 T5605 arg1Of GATA-3,(
R4829 T5604 T5611 arg1Of GATA-3,from
R4830 T5604 T5616 arg1Of GATA-3,were
R4831 T5604 T5617 arg2Of GATA-3,added
R4832 T5607 T5605 arg2Of ng/ml,(
R4833 T5607 T5606 arg1Of ng/ml,100
R4834 T5607 T5608 arg1Of ng/ml,in
R4835 T5609 T5608 arg2Of TBS,in
R4836 T5610 T5605 arg3Of ),(
R4837 T5615 T5611 arg2Of cells,from
R4838 T5615 T5612 arg2Of cells,stimulated
R4839 T5615 T5613 arg1Of cells,or
R4840 T5615 T5614 arg1Of cells,unstimulated
R4841 T5617 T5599 arg1Of added,After
R4842 T5617 T5603 arg1Of added,","
R4843 T5617 T5616 arg2Of added,were
R4844 T5617 T5618 arg1Of added,to
R4845 T5621 T5618 arg2Of wells,to
R4846 T5621 T5619 arg1Of wells,the
R4847 T5621 T5620 arg1Of wells,importin-α-coated
R4848 T5622 T5623 arg1Of GR,(
R4849 T5622 T5631 arg1Of GR,from
R4850 T5622 T5636 arg1Of GR,were
R4851 T5622 T5637 arg2Of GR,added
R4852 T5624 T5625 arg1Of 10,or
R4853 T5626 T5625 arg2Of 100,or
R4854 T5627 T5623 arg2Of ng/ml,(
R4855 T5627 T5624 arg1Of ng/ml,10
R4856 T5627 T5626 arg1Of ng/ml,100
R4857 T5627 T5628 arg1Of ng/ml,in
R4858 T5629 T5628 arg2Of TBS,in
R4859 T5630 T5623 arg3Of ),(
R4860 T5635 T5631 arg2Of cells,from
R4861 T5635 T5632 arg2Of cells,stimulated
R4862 T5635 T5633 arg1Of cells,or
R4863 T5635 T5634 arg1Of cells,unstimulated
R4864 T5637 T5636 arg2Of added,were
R4865 T5637 T5638 arg1Of added,to
R4866 T5640 T5638 arg2Of wells,to
R4867 T5640 T5639 arg1Of wells,some
R4868 T5644 T5645 arg1Of 1,h
R4869 T5646 T5641 arg2Of incubation,After
R4870 T5646 T5642 arg1Of incubation,a
R4871 T5646 T5643 arg1Of incubation,further
R4872 T5646 T5644 arg1Of incubation,1
R4873 T5649 T5648 arg1Of plate,the
R4874 T5649 T5650 arg1Of plate,was
R4875 T5649 T5651 arg2Of plate,washed
R4876 T5649 T5653 arg2Of plate,incubated
R4877 T5649 T5677 arg2Of plate,incubated
R4878 T5651 T5652 arg1Of washed,and
R4879 T5652 T5654 arg1Of and,with
R4880 T5652 T5675 arg1Of and,and
R4881 T5653 T5652 arg2Of incubated,and
R4882 T5656 T5654 arg2Of antibodies,with
R4883 T5656 T5655 arg1Of antibodies,primary
R4884 T5656 T5657 arg1Of antibodies,(
R4885 T5656 T5671 arg1Of antibodies,for
R4886 T5659 T5657 arg2Of mixture,(
R4887 T5659 T5658 arg1Of mixture,a
R4888 T5659 T5660 arg1Of mixture,of
R4889 T5662 T5661 arg1Of anti-GATA-3,rabbit
R4890 T5662 T5663 arg1Of anti-GATA-3,and
R4891 T5663 T5660 arg2Of and,of
R4892 T5663 T5666 arg1Of and,","
R4893 T5665 T5663 arg2Of anti-GR,and
R4894 T5665 T5664 arg1Of anti-GR,mouse
R4895 T5669 T5666 arg2Of Biotechnology,","
R4896 T5669 T5667 arg1Of Biotechnology,Santa
R4897 T5669 T5668 arg1Of Biotechnology,Cruz
R4898 T5670 T5657 arg3Of ),(
R4899 T5673 T5671 arg2Of h,for
R4900 T5673 T5672 arg1Of h,1.5
R4901 T5675 T5641 arg1Of and,After
R4902 T5675 T5647 arg1Of and,","
R4903 T5675 T5650 arg2Of and,was
R4904 T5675 T5674 arg1Of and,","
R4905 T5677 T5675 arg2Of incubated,and
R4906 T5677 T5676 arg1Of incubated,then
R4907 T5677 T5678 arg1Of incubated,with
R4908 T5680 T5678 arg2Of antibodies,with
R4909 T5680 T5679 arg1Of antibodies,secondary
R4910 T5684 T5681 arg1Of IgG,FITC
R4911 T5684 T5682 arg1Of IgG,swine
R4912 T5684 T5683 arg1Of IgG,anti-rabbit
R4913 T5684 T5685 arg1Of IgG,(
R4914 T5684 T5692 arg1Of IgG,was
R4915 T5684 T5693 arg2Of IgG,used
R4916 T5686 T5685 arg2Of Dako,(
R4917 T5686 T5687 arg1Of Dako,","
R4918 T5688 T5687 arg2Of Cambridge,","
R4919 T5688 T5689 arg1Of Cambridge,","
R4920 T5690 T5689 arg2Of UK,","
R4921 T5691 T5685 arg3Of ),(
R4922 T5693 T5692 arg2Of used,was
R4923 T5693 T5694 arg1Of used,for
R4924 T5693 T5700 arg1Of used,and
R4925 T5696 T5694 arg2Of detection,for
R4926 T5696 T5695 arg1Of detection,the
R4927 T5696 T5697 arg1Of detection,of
R4928 T5698 T5697 arg2Of GATA-3,of
R4929 T5700 T5699 arg1Of and,","
R4930 T5704 T5701 arg1Of IgG,rhodamine
R4931 T5704 T5702 arg1Of IgG,donkey
R4932 T5704 T5703 arg1Of IgG,anti-mouse
R4933 T5704 T5705 arg1Of IgG,(
R4934 T5704 T5714 arg1Of IgG,was
R4935 T5704 T5715 arg2Of IgG,used
R4936 T5706 T5707 arg1Of Novus,","
R4937 T5707 T5709 arg1Of ",",","
R4938 T5708 T5707 arg2Of Littleton,","
R4939 T5709 T5705 arg2Of ",",(
R4940 T5709 T5711 arg1Of ",",","
R4941 T5709 T5712 arg1Of ",",USA
R4942 T5710 T5709 arg2Of Colorado,","
R4943 T5713 T5705 arg3Of ),(
R4944 T5715 T5700 arg2Of used,and
R4945 T5715 T5714 arg2Of used,was
R4946 T5715 T5716 arg1Of used,for
R4947 T5718 T5716 arg2Of detection,for
R4948 T5718 T5717 arg1Of detection,the
R4949 T5718 T5719 arg1Of detection,of
R4950 T5720 T5719 arg2Of GR,of
R4951 T5721 T5722 arg1Of FITC,and
R4952 T5723 T5722 arg2Of rhodamine,and
R4953 T5724 T5721 arg1Of levels,FITC
R4954 T5724 T5723 arg1Of levels,rhodamine
R4955 T5724 T5725 arg1Of levels,were
R4956 T5724 T5726 arg2Of levels,measured
R4957 T5726 T5725 arg2Of measured,were
R4958 T5726 T5727 arg1Of measured,with
R4959 T5726 T5732 arg1Of measured,(
R4960 T5731 T5727 arg2Of reader,with
R4961 T5731 T5728 arg1Of reader,a
R4962 T5731 T5729 arg1Of reader,fluorescent
R4963 T5731 T5730 arg1Of reader,micro-plate
R4964 T5733 T5732 arg2Of Bioline,(
R4965 T5733 T5734 arg1Of Bioline,","
R4966 T5735 T5734 arg2Of London,","
R4967 T5735 T5736 arg1Of London,","
R4968 T5737 T5736 arg2Of UK,","
R4969 T5738 T5732 arg3Of ),(
R5227 T6081 T6080 arg1Of Activation,NF-κB
R5228 T6084 T6082 arg1Of activity,NF-κB
R5229 T6084 T6083 arg1Of activity,binding
R5230 T6084 T6085 arg1Of activity,in
R5231 T6084 T6088 arg1Of activity,was
R5232 T6084 T6089 arg2Of activity,determined
R5233 T6087 T6085 arg2Of extracts,in
R5234 T6087 T6086 arg1Of extracts,nuclear
R5235 T6089 T6088 arg2Of determined,was
R5236 T6090 T6089 arg3Of using,determined
R5237 T6093 T6090 arg2Of kit,using
R5238 T6093 T6091 arg1Of kit,an
R5239 T6093 T6092 arg1Of kit,ELISA-based
R5240 T6093 T6094 arg1Of kit,(
R5241 T6096 T6095 arg1Of p65,Trans-AM
R5242 T6096 T6097 arg1Of p65,","
R5243 T6096 T6100 arg1Of p65,","
R5244 T6099 T6097 arg2Of Motif,","
R5245 T6099 T6098 arg1Of Motif,Active
R5246 T6100 T6094 arg2Of ",",(
R5247 T6101 T6100 arg2Of Rixensart,","
R5248 T6101 T6102 arg1Of Rixensart,","
R5249 T6103 T6102 arg2Of Belgium,","
R5250 T6104 T6094 arg3Of ),(
R5251 T6106 T6105 arg2Of brief,In
R5252 T6109 T6108 arg1Of µg,5
R5253 T6109 T6110 arg1Of µg,of
R5254 T6109 T6113 arg1Of µg,were
R5255 T6109 T6114 arg2Of µg,incubated
R5256 T6112 T6110 arg2Of extracts,of
R5257 T6112 T6111 arg1Of extracts,nuclear
R5258 T6114 T6105 arg1Of incubated,In
R5259 T6114 T6107 arg1Of incubated,","
R5260 T6114 T6113 arg2Of incubated,were
R5261 T6114 T6115 arg1Of incubated,with
R5262 T6117 T6115 arg2Of plate,with
R5263 T6117 T6116 arg1Of plate,a
R5264 T6117 T6118 arg2Of plate,coated
R5265 T6118 T6119 arg1Of coated,with
R5266 T6123 T6119 arg2Of oligonucleotide,with
R5267 T6123 T6120 arg1Of oligonucleotide,an
R5268 T6123 T6121 arg1Of oligonucleotide,NF-κB
R5269 T6123 T6122 arg1Of oligonucleotide,consensus
R5270 T6124 T6125 arg1Of Plates,were
R5271 T6124 T6126 arg2Of Plates,washed
R5272 T6126 T6125 arg2Of washed,were
R5273 T6126 T6127 arg1Of washed,before
R5274 T6128 T6127 arg2Of addition,before
R5275 T6128 T6129 arg1Of addition,of
R5276 T6132 T6129 arg2Of antibody,of
R5277 T6132 T6130 arg1Of antibody,an
R5278 T6132 T6131 arg1Of antibody,anti-p65
R5279 T6134 T6133 arg1Of binding,Antibody
R5280 T6134 T6135 arg1Of binding,was
R5281 T6134 T6136 arg2Of binding,detected
R5282 T6134 T6143 arg2Of binding,developed
R5283 T6136 T6137 arg1Of detected,with
R5284 T6136 T6142 arg1Of detected,and
R5285 T6141 T6137 arg2Of antibody,with
R5286 T6141 T6138 arg1Of antibody,a
R5287 T6141 T6139 arg1Of antibody,secondary
R5288 T6141 T6140 arg1Of antibody,HRP-conjugated
R5289 T6142 T6135 arg2Of and,was
R5290 T6143 T6142 arg2Of developed,and
R5291 T6143 T6144 arg1Of developed,with
R5292 T6146 T6144 arg2Of substrate,with
R5293 T6146 T6145 arg1Of substrate,TMB
R5294 T6148 T6147 arg1Of intensity,The
R5295 T6148 T6149 arg1Of intensity,of
R5296 T6148 T6152 arg1Of intensity,was
R5297 T6148 T6153 arg2Of intensity,measured
R5298 T6151 T6149 arg2Of reaction,of
R5299 T6151 T6150 arg1Of reaction,the
R5300 T6153 T6152 arg2Of measured,was
R5301 T6153 T6154 arg1Of measured,at
R5302 T6156 T6154 arg2Of nm,at
R5303 T6156 T6155 arg1Of nm,450
R5389 T6284 T6283 arg1Of Staining,Immunofluorescence
R5390 T6286 T6285 arg1Of staining,Immunofluorescence
R5391 T6286 T6287 arg1Of staining,was
R5392 T6286 T6288 arg2Of staining,performed
R5393 T6288 T6287 arg2Of performed,was
R5394 T6288 T6289 arg1Of performed,as
R5395 T6291 T6290 arg1Of described,previously
R5396 T6293 T6289 arg2Of 34,as
R5397 T6293 T6291 arg1Of 34,described
R5398 T6293 T6292 arg2Of 34,[
R5399 T6294 T6292 arg3Of ],[
R5400 T6296 T6295 arg1Of staining,All
R5401 T6296 T6297 arg1Of staining,was
R5402 T6296 T6298 arg2Of staining,performed
R5403 T6298 T6297 arg2Of performed,was
R5404 T6298 T6299 arg1Of performed,at
R5405 T6298 T6303 arg1Of performed,under
R5406 T6299 T6302 arg1Of at,and
R5407 T6301 T6299 arg2Of temperature,at
R5408 T6301 T6300 arg1Of temperature,room
R5409 T6303 T6302 arg2Of under,and
R5410 T6304 T6303 arg2Of humidification,under
R5411 T6305 T6306 arg1Of Cells,were
R5412 T6305 T6307 arg2Of Cells,collected
R5413 T6307 T6306 arg2Of collected,were
R5414 T6307 T6308 arg1Of collected,and
R5415 T6308 T6314 arg1Of and,(
R5416 T6309 T6310 arg2Of cytospins,prepared
R5417 T6310 T6308 arg2Of prepared,and
R5418 T6310 T6311 arg1Of prepared,in
R5419 T6313 T6311 arg2Of cytocentrifuge,in
R5420 T6313 T6312 arg1Of cytocentrifuge,a
R5421 T6316 T6315 arg1Of II,Shandon
R5422 T6316 T6317 arg1Of II,","
R5423 T6317 T6319 arg1Of ",",","
R5424 T6318 T6317 arg2Of Shandon,","
R5425 T6319 T6314 arg2Of ",",(
R5426 T6319 T6321 arg1Of ",",","
R5427 T6320 T6319 arg2Of Runcorn,","
R5428 T6322 T6321 arg2Of UK,","
R5429 T6323 T6314 arg3Of ),(
R5430 T6324 T6325 arg1Of Cells,were
R5431 T6324 T6326 arg2Of Cells,permeabilized
R5432 T6324 T6328 arg2Of Cells,blocked
R5433 T6324 T6332 arg2Of Cells,incubated
R5434 T6326 T6327 arg1Of permeabilized,","
R5435 T6327 T6330 arg1Of ",",and
R5436 T6328 T6327 arg2Of blocked,","
R5437 T6330 T6325 arg2Of and,were
R5438 T6330 T6329 arg1Of and,","
R5439 T6332 T6330 arg2Of incubated,and
R5440 T6332 T6331 arg1Of incubated,then
R5441 T6332 T6333 arg1Of incubated,with
R5442 T6334 T6335 arg1Of GR,(
R5443 T6334 T6342 arg1Of GR,or
R5444 T6340 T6335 arg2Of Biotechnology,(
R5445 T6340 T6336 arg1Of Biotechnology,1∶50
R5446 T6340 T6337 arg1Of Biotechnology,E-20
R5447 T6340 T6338 arg1Of Biotechnology,Santa
R5448 T6340 T6339 arg1Of Biotechnology,Cruz
R5449 T6341 T6335 arg3Of ),(
R5450 T6342 T6333 arg2Of or,with
R5451 T6343 T6344 arg1Of anti-GATA-3,(
R5452 T6345 T6344 arg2Of H-48,(
R5453 T6345 T6346 arg1Of H-48,;
R5454 T6349 T6346 arg2Of Biotechnology,;
R5455 T6349 T6347 arg1Of Biotechnology,Santa
R5456 T6349 T6348 arg1Of Biotechnology,Cruz
R5457 T6350 T6344 arg3Of ),(
R5458 T6351 T6342 arg2Of antibody,or
R5459 T6351 T6343 arg1Of antibody,anti-GATA-3
R5460 T6351 T6352 arg1Of antibody,for
R5461 T6354 T6352 arg2Of h,for
R5462 T6354 T6353 arg1Of h,1
R5463 T6354 T6355 arg1Of h,at
R5464 T6357 T6355 arg2Of temperature,at
R5465 T6357 T6356 arg1Of temperature,room
R5466 T6360 T6358 arg2Of washes,After
R5467 T6360 T6359 arg1Of washes,three
R5468 T6360 T6361 arg1Of washes,in
R5469 T6363 T6361 arg2Of saline,in
R5470 T6363 T6362 arg1Of saline,phosphate-buffered
R5471 T6363 T6364 arg1Of saline,(
R5472 T6365 T6364 arg2Of PBS,(
R5473 T6366 T6364 arg3Of ),(
R5474 T6368 T6369 arg1Of cells,were
R5475 T6368 T6370 arg2Of cells,incubated
R5476 T6370 T6358 arg1Of incubated,After
R5477 T6370 T6367 arg1Of incubated,","
R5478 T6370 T6369 arg2Of incubated,were
R5479 T6370 T6371 arg1Of incubated,with
R5480 T6372 T6371 arg2Of tetrarhodamine,with
R5481 T6372 T6373 arg2Of tetrarhodamine,isothiocyanate–conjugated
R5482 T6376 T6373 arg3Of antibody,isothiocyanate–conjugated
R5483 T6376 T6374 arg1Of antibody,goat
R5484 T6376 T6375 arg1Of antibody,anti-rabbit
R5485 T6376 T6377 arg1Of antibody,(
R5486 T6378 T6377 arg2Of Dako,(
R5487 T6379 T6377 arg3Of ),(
R5488 T6380 T6381 arg1Of Cytospins,were
R5489 T6380 T6382 arg2Of Cytospins,counterstained
R5490 T6380 T6401 arg1Of Cytospins,mounted
R5491 T6382 T6381 arg2Of counterstained,were
R5492 T6382 T6383 arg1Of counterstained,with
R5493 T6382 T6400 arg1Of counterstained,and
R5494 T6384 T6383 arg2Of 4′,with
R5495 T6384 T6385 arg1Of 4′,","
R5496 T6384 T6391 arg1Of 4′,","
R5497 T6387 T6385 arg2Of dihydrochloride,","
R5498 T6387 T6386 arg1Of dihydrochloride,6-diamidino-2-phenylindole
R5499 T6387 T6388 arg1Of dihydrochloride,(
R5500 T6389 T6388 arg2Of DAPI,(
R5501 T6390 T6388 arg3Of ),(
R5502 T6398 T6391 arg2Of stain,","
R5503 T6398 T6392 arg1Of stain,a
R5504 T6398 T6393 arg1Of stain,fluorescent
R5505 T6398 T6394 arg1Of stain,blue
R5506 T6398 T6395 arg1Of stain,nuclear
R5507 T6398 T6396 arg1Of stain,indole
R5508 T6398 T6397 arg1Of stain,chromatin
R5509 T6400 T6399 arg1Of and,","
R5510 T6401 T6400 arg2Of mounted,and
R5511 T6401 T6402 arg1Of mounted,in
R5512 T6401 T6404 arg1Of mounted,:
R5513 T6403 T6402 arg2Of PBS,in
R5514 T6405 T6401 arg2Of glycerol,mounted
R5515 T6405 T6406 arg1Of glycerol,(
R5516 T6407 T6406 arg2Of 50∶50,(
R5517 T6408 T6406 arg3Of ),(
R5518 T6411 T6409 arg1Of signal,The
R5519 T6411 T6410 arg1Of signal,immunopositive
R5520 T6411 T6412 arg1Of signal,was
R5521 T6411 T6413 arg2Of signal,characterised
R5522 T6411 T6414 arg1Of signal,using
R5523 T6413 T6412 arg2Of characterised,was
R5524 T6414 T6413 arg3Of using,characterised
R5525 T6414 T6419 arg1Of using,on
R5526 T6418 T6414 arg2Of microscopy,using
R5527 T6418 T6415 arg1Of microscopy,laser
R5528 T6418 T6416 arg1Of microscopy,scanning
R5529 T6418 T6417 arg1Of microscopy,confocal
R5530 T6423 T6421 arg1Of NT/SP,Leica
R5531 T6423 T6422 arg1Of NT/SP,TCS
R5532 T6426 T6419 arg2Of cytometer,on
R5533 T6426 T6420 arg1Of cytometer,a
R5534 T6426 T6423 arg1Of cytometer,NT/SP
R5535 T6426 T6424 arg1Of cytometer,interactive
R5536 T6426 T6425 arg1Of cytometer,laser
R5537 T6426 T6427 arg2Of cytometer,equipped
R5538 T6427 T6428 arg1Of equipped,with
R5539 T6430 T6428 arg2Of optics,with
R5540 T6430 T6429 arg1Of optics,confocal
R5541 T6430 T6431 arg1Of optics,(
R5542 T6433 T6431 arg2Of Microsystems,(
R5543 T6433 T6432 arg1Of Microsystems,Leica
R5544 T6433 T6434 arg1Of Microsystems,","
R5545 T6435 T6434 arg2Of Wetzlar,","
R5546 T6435 T6436 arg1Of Wetzlar,","
R5547 T6437 T6436 arg2Of Germany,","
R5548 T6438 T6431 arg3Of ),(
R5549 T6440 T6439 arg1Of determine,To
R5550 T6442 T6440 arg2Of specificity,determine
R5551 T6442 T6441 arg1Of specificity,the
R5552 T6442 T6443 arg1Of specificity,of
R5553 T6445 T6443 arg2Of antibodies,of
R5554 T6445 T6444 arg1Of antibodies,the
R5555 T6449 T6447 arg1Of immunoglobulin,rabbit
R5556 T6449 T6448 arg1Of immunoglobulin,serum
R5557 T6449 T6450 arg1Of immunoglobulin,(
R5558 T6449 T6453 arg1Of immunoglobulin,and
R5559 T6451 T6450 arg2Of Dako,(
R5560 T6452 T6450 arg3Of ),(
R5561 T6453 T6456 arg1Of and,without
R5562 T6453 T6459 arg1Of and,were
R5563 T6453 T6460 arg2Of and,used
R5564 T6455 T6453 arg2Of antibodies,and
R5565 T6455 T6454 arg1Of antibodies,secondary
R5566 T6458 T6456 arg2Of primary,without
R5567 T6458 T6457 arg1Of primary,the
R5568 T6460 T6439 modOf used,To
R5569 T6460 T6446 arg1Of used,","
R5570 T6460 T6459 arg2Of used,were
R5571 T6460 T6461 arg1Of used,as
R5572 T6462 T6461 arg2Of controls,as
R5573 T6464 T6463 arg1Of stained,Positively
R5574 T6465 T6464 arg1Of nuclei,stained
R5575 T6465 T6466 arg1Of nuclei,and
R5576 T6466 T6469 arg1Of and,were
R5577 T6466 T6470 arg2Of and,counted
R5578 T6468 T6466 arg2Of cells,and
R5579 T6468 T6467 arg1Of cells,total
R5580 T6470 T6469 arg2Of counted,were
R5581 T6470 T6471 arg1Of counted,(
R5582 T6470 T6474 arg1Of counted,on
R5583 T6472 T6471 arg2Of 500,(
R5584 T6473 T6471 arg3Of ),(
R5585 T6476 T6474 arg2Of slide,on
R5586 T6476 T6475 arg1Of slide,each
R5587 T6476 T6477 arg1Of slide,with
R5588 T6479 T6477 arg2Of observer,with
R5589 T6479 T6478 arg1Of observer,the
R5590 T6479 T6480 arg2Of observer,blinded
R5591 T6480 T6481 arg1Of blinded,to
R5592 T6483 T6481 arg2Of treatment,to
R5593 T6483 T6482 arg1Of treatment,the
R5815 T6780 T6779 arg1Of Construct,GATA-3-GFP
R5816 T6785 T6784 arg2Of BC003070,(
R5817 T6786 T6784 arg3Of ),(
R5818 T6788 T6781 arg1Of cDNA,The
R5819 T6788 T6782 arg1Of cDNA,GATA-3
R5820 T6788 T6783 arg1Of cDNA,clone
R5821 T6788 T6784 arg1Of cDNA,(
R5822 T6788 T6787 arg1Of cDNA,complete
R5823 T6788 T6789 arg1Of cDNA,was
R5824 T6788 T6790 arg2Of cDNA,obtained
R5825 T6790 T6789 arg2Of obtained,was
R5826 T6790 T6791 arg1Of obtained,from
R5827 T6790 T6795 arg1Of obtained,as
R5828 T6794 T6791 arg2Of Technologies,from
R5829 T6794 T6792 arg1Of Technologies,Invitrogen
R5830 T6794 T6793 arg1Of Technologies,Life
R5831 T6799 T6795 arg2Of insert,as
R5832 T6799 T6796 arg1Of insert,a
R5833 T6799 T6797 arg1Of insert,5′-
R5834 T6799 T6798 arg1Of insert,EcoRI/3′-XhoI
R5835 T6799 T6800 arg1Of insert,of
R5836 T6799 T6802 arg1Of insert,in
R5837 T6801 T6800 arg2Of GATA-3,of
R5838 T6805 T6802 arg2Of vector,in
R5839 T6805 T6803 arg1Of vector,the
R5840 T6805 T6804 arg1Of vector,pOTB7
R5841 T6806 T6807 arg1Of GATA-3,was
R5842 T6806 T6808 arg2Of GATA-3,excised
R5843 T6808 T6807 arg2Of excised,was
R5844 T6808 T6809 arg1Of excised,from
R5845 T6810 T6809 arg2Of pOTB7,from
R5846 T6813 T6811 arg1Of digestion,using
R5847 T6813 T6812 arg1Of digestion,XhoI
R5848 T6813 T6814 arg1Of digestion,and
R5849 T6814 T6823 arg1Of and,was
R5850 T6814 T6824 arg2Of and,digested
R5851 T6815 T6814 arg2Of pEGFP-C2,and
R5852 T6815 T6816 arg1Of pEGFP-C2,(
R5853 T6817 T6818 arg1Of Clontech,","
R5854 T6818 T6820 arg1Of ",",","
R5855 T6819 T6818 arg2Of Saint-Germain-en-Laye,","
R5856 T6820 T6816 arg2Of ",",(
R5857 T6821 T6820 arg2Of France,","
R5858 T6822 T6816 arg3Of ),(
R5859 T6824 T6807 modOf digested,was
R5860 T6824 T6823 arg2Of digested,was
R5861 T6824 T6825 arg1Of digested,with
R5862 T6826 T6825 arg2Of BamHI,with
R5863 T6827 T6828 arg1Of DNA,was
R5864 T6827 T6829 arg2Of DNA,recovered
R5865 T6829 T6828 arg2Of recovered,was
R5866 T6832 T6831 arg1Of extraction,phenol
R5867 T6832 T6833 arg1Of extraction,and
R5868 T6833 T6829 arg1Of and,recovered
R5869 T6833 T6830 arg2Of and,by
R5870 T6835 T6833 arg2Of precipitation,and
R5871 T6835 T6834 arg1Of precipitation,ethanol
R5872 T6837 T6836 arg1Of and,","
R5873 T6841 T6839 arg1Of fragment,the
R5874 T6841 T6840 arg1Of fragment,GATA-3
R5875 T6841 T6842 arg1Of fragment,and
R5876 T6842 T6838 arg1Of and,both
R5877 T6845 T6842 arg2Of vector,and
R5878 T6845 T6843 arg1Of vector,the
R5879 T6845 T6844 arg1Of vector,pEGFP-C2
R5880 T6845 T6846 arg1Of vector,blunt-ended
R5881 T6848 T6847 arg2Of incubation,by
R5882 T6850 T6849 arg2Of Klenow,with
R5883 T6852 T6851 arg2Of Bioline,(
R5884 T6852 T6853 arg1Of Bioline,Bio-27029
R5885 T6854 T6851 arg3Of ),(
R5886 T6857 T6855 arg2Of min,for
R5887 T6857 T6856 arg1Of min,30
R5888 T6860 T6859 arg1Of Klenow,37°C.
R5889 T6860 T6861 arg1Of Klenow,was
R5890 T6860 T6862 arg2Of Klenow,inactivated
R5891 T6862 T6861 arg2Of inactivated,was
R5892 T6862 T6863 arg1Of inactivated,by
R5893 T6864 T6863 arg2Of incubation,by
R5894 T6864 T6865 arg1Of incubation,for
R5895 T6867 T6865 arg2Of min,for
R5896 T6867 T6866 arg1Of min,10
R5897 T6867 T6868 arg1Of min,at
R5898 T6870 T6868 arg2Of DNA,at
R5899 T6870 T6869 arg1Of DNA,75°C.
R5900 T6872 T6871 arg2Of recovered,was
R5901 T6875 T6874 arg1Of extraction,phenol
R5902 T6875 T6876 arg1Of extraction,and
R5903 T6876 T6872 arg1Of and,recovered
R5904 T6876 T6873 arg2Of and,by
R5905 T6878 T6876 arg2Of precipitation,and
R5906 T6878 T6877 arg1Of precipitation,ethanol
R5907 T6880 T6879 arg1Of and,","
R5908 T6885 T6882 arg1Of fragment,the
R5909 T6885 T6883 arg1Of fragment,blunt-ended
R5910 T6885 T6884 arg1Of fragment,GATA-3
R5911 T6885 T6886 arg1Of fragment,and
R5912 T6886 T6881 arg1Of and,both
R5913 T6886 T6890 arg1Of and,were
R5914 T6886 T6892 arg2Of and,digested
R5915 T6889 T6886 arg2Of vector,and
R5916 T6889 T6887 arg1Of vector,the
R5917 T6889 T6888 arg1Of vector,GFP
R5918 T6892 T6880 arg2Of digested,and
R5919 T6892 T6890 arg2Of digested,were
R5920 T6892 T6891 arg1Of digested,subsequently
R5921 T6892 T6893 arg1Of digested,with
R5922 T6892 T6895 arg1Of digested,before
R5923 T6894 T6893 arg2Of EcoRI,with
R5924 T6900 T6896 arg1Of fragment,the
R5925 T6900 T6897 arg1Of fragment,5′-EcoRI/3′–blunt
R5926 T6900 T6898 arg1Of fragment,end
R5927 T6900 T6899 arg1Of fragment,GATA-3
R5928 T6900 T6901 arg1Of fragment,was
R5929 T6900 T6902 arg2Of fragment,inserted
R5930 T6902 T6895 arg2Of inserted,before
R5931 T6902 T6901 arg2Of inserted,was
R5932 T6902 T6903 arg1Of inserted,into
R5933 T6906 T6905 arg1Of ended,5′-EcoRI/3′–blunt
R5934 T6908 T6903 arg2Of vector,into
R5935 T6908 T6904 arg1Of vector,the
R5936 T6908 T6906 arg1Of vector,ended
R5937 T6908 T6907 arg1Of vector,GFP
R5938 T6910 T6909 arg1Of clones,Positive
R5939 T6910 T6911 arg1Of clones,were
R5940 T6910 T6912 arg2Of clones,confirmed
R5941 T6912 T6911 arg2Of confirmed,were
R5942 T6912 T6918 arg1Of confirmed,by
R5943 T6912 T6925 arg1Of confirmed,by
R5944 T6914 T6915 arg1Of digestion,and
R5945 T6916 T6915 arg2Of size,and
R5946 T6917 T6912 arg1Of analysis,confirmed
R5947 T6917 T6913 arg2Of analysis,by
R5948 T6917 T6914 arg1Of analysis,digestion
R5949 T6917 T6916 arg1Of analysis,size
R5950 T6918 T6924 arg1Of by,and
R5951 T6919 T6920 arg1Of 1,%
R5952 T6923 T6918 arg2Of electrophoresis,by
R5953 T6923 T6919 arg1Of electrophoresis,1
R5954 T6923 T6921 arg1Of electrophoresis,agarose
R5955 T6923 T6922 arg1Of electrophoresis,gel
R5956 T6925 T6924 arg2Of by,and
R5957 T6926 T6925 arg2Of sequencing,by
R6131 T7174 T7173 arg1Of cells,HuT-78
R6132 T7174 T7175 arg1Of cells,were
R6133 T7174 T7176 arg2Of cells,transfected
R6134 T7176 T7175 arg2Of transfected,were
R6135 T7176 T7177 arg1Of transfected,with
R6136 T7179 T7180 arg1Of EP8,or
R6137 T7180 T7177 arg2Of or,with
R6138 T7180 T7178 arg1Of or,either
R6139 T7182 T7180 arg2Of vector,or
R6140 T7182 T7181 arg1Of vector,GFP
R6141 T7184 T7183 arg1Of DNA,only
R6142 T7184 T7185 arg1Of DNA,using
R6143 T7184 T7197 arg1Of DNA,µg
R6144 T7187 T7185 arg2Of R,using
R6145 T7187 T7186 arg1Of R,solution
R6146 T7187 T7188 arg1Of R,","
R6147 T7190 T7188 arg2Of V-001,","
R6148 T7190 T7189 arg1Of V-001,programme
R6149 T7190 T7191 arg1Of V-001,at
R6150 T7193 T7191 arg2Of ratio,at
R6151 T7193 T7192 arg1Of ratio,a
R6152 T7193 T7194 arg1Of ratio,of
R6153 T7196 T7194 arg2Of cells/4,of
R6154 T7196 T7195 arg1Of cells/4,3×106
R6155 T7197 T7175 modOf µg,were
R6156 T7197 T7199 arg1Of µg,for
R6157 T7197 T7202 arg1Of µg,in
R6158 T7197 T7214 arg1Of µg,according
R6159 T7198 T7197 arg2Of DNA,µg
R6160 T7201 T7199 arg2Of h,for
R6161 T7201 T7200 arg1Of h,7–8
R6162 T7204 T7202 arg2Of medium,in
R6163 T7204 T7203 arg1Of medium,complete
R6164 T7204 T7205 arg1Of medium,(
R6165 T7206 T7207 arg1Of 10,%
R6166 T7209 T7205 arg2Of serum,(
R6167 T7209 T7206 arg1Of serum,10
R6168 T7209 T7208 arg1Of serum,bovine
R6169 T7209 T7210 arg1Of serum,in
R6170 T7212 T7210 arg2Of L-glutamine,in
R6171 T7212 T7211 arg1Of L-glutamine,RPMI1640+15
R6172 T7213 T7205 arg3Of ),(
R6173 T7215 T7214 arg2Of to,according
R6174 T7219 T7215 arg2Of protocol,to
R6175 T7219 T7216 arg1Of protocol,the
R6176 T7219 T7217 arg1Of protocol,general
R6177 T7219 T7218 arg1Of protocol,Amaxa
R6178 T7219 T7220 arg1Of protocol,for
R6179 T7221 T7220 arg2Of nucleofection,for
R6180 T7223 T7222 arg1Of medium,The
R6181 T7223 T7224 arg1Of medium,was
R6182 T7223 T7226 arg2Of medium,changed
R6183 T7226 T7224 arg2Of changed,was
R6184 T7226 T7225 arg1Of changed,subsequently
R6185 T7226 T7227 arg1Of changed,to
R6186 T7226 T7231 arg1Of changed,for
R6187 T7228 T7229 arg1Of 1,%
R6188 T7230 T7227 arg2Of RPMI,to
R6189 T7230 T7228 arg1Of RPMI,1
R6190 T7233 T7232 arg1Of h,24
R6191 T7233 T7234 arg1Of h,before
R6192 T7233 T7243 arg1Of h,and
R6193 T7236 T7235 arg2Of cells,transfected
R6194 T7236 T7237 arg1Of cells,were
R6195 T7236 T7238 arg2Of cells,added
R6196 T7238 T7234 arg2Of added,before
R6197 T7238 T7237 arg2Of added,were
R6198 T7238 T7239 arg1Of added,to
R6199 T7242 T7239 arg2Of wells,to
R6200 T7242 T7240 arg1Of wells,anti-CD3/CD28
R6201 T7242 T7241 arg2Of wells,treated
R6202 T7243 T7231 arg2Of and,for
R6203 T7246 T7243 arg2Of videomicroscopy,and
R6204 T7246 T7244 arg1Of videomicroscopy,live
R6205 T7246 T7245 arg1Of videomicroscopy,cell
R6206 T7246 T7247 arg2Of videomicroscopy,performed
R6294 T7358 T7357 arg1Of Microscopy,Time-Lapse
R6295 T7360 T7359 arg1Of cells,HuT-78
R6296 T7360 T7361 arg1Of cells,expressing
R6297 T7360 T7363 arg1Of cells,were
R6298 T7360 T7364 arg2Of cells,maintained
R6299 T7362 T7361 arg2Of GATA-3-GFP,expressing
R6300 T7364 T7363 arg2Of maintained,were
R6301 T7364 T7365 arg1Of maintained,at
R6302 T7364 T7367 arg1Of maintained,in
R6303 T7366 T7365 arg2Of 37°C,at
R6304 T7369 T7367 arg2Of medium,in
R6305 T7369 T7368 arg1Of medium,growth
R6306 T7369 T7370 arg1Of medium,in
R6307 T7369 T7376 arg1Of medium,(
R6308 T7369 T7385 arg2Of medium,combined
R6309 T7375 T7370 arg2Of chamber,in
R6310 T7375 T7371 arg1Of chamber,a
R6311 T7375 T7372 arg1Of chamber,closed
R6312 T7375 T7373 arg1Of chamber,FCS2
R6313 T7375 T7374 arg1Of chamber,perfusion
R6314 T7377 T7378 arg1Of Bioptechs,","
R6315 T7378 T7380 arg1Of ",",","
R6316 T7379 T7378 arg2Of Butler,","
R6317 T7380 T7376 arg2Of ",",(
R6318 T7380 T7382 arg1Of ",",","
R6319 T7380 T7383 arg1Of ",",USA
R6320 T7381 T7380 arg2Of Pennsylvania,","
R6321 T7384 T7376 arg3Of ),(
R6322 T7385 T7386 arg1Of combined,with
R6323 T7385 T7393 arg1Of combined,on
R6324 T7385 T7401 arg1Of combined,(
R6325 T7389 T7386 arg2Of heater,with
R6326 T7389 T7387 arg1Of heater,an
R6327 T7389 T7388 arg1Of heater,objective
R6328 T7389 T7390 arg1Of heater,(
R6329 T7391 T7390 arg2Of Bioptechs,(
R6330 T7392 T7390 arg3Of ),(
R6331 T7395 T7393 arg2Of stage,on
R6332 T7395 T7394 arg1Of stage,the
R6333 T7398 T7397 arg1Of Axiovert,Zeiss
R6334 T7398 T7399 arg1Of Axiovert,200
R6335 T7400 T7393 arg3Of microscope,on
R6336 T7400 T7396 arg1Of microscope,a
R6337 T7400 T7398 arg1Of microscope,Axiovert
R6338 T7402 T7401 arg2Of Thornwood,(
R6339 T7402 T7403 arg1Of Thornwood,","
R6340 T7405 T7403 arg2Of York,","
R6341 T7405 T7404 arg1Of York,New
R6342 T7405 T7406 arg1Of York,","
R6343 T7407 T7406 arg2Of USA,","
R6344 T7408 T7401 arg3Of ),(
R6345 T7409 T7410 arg1Of Observations,were
R6346 T7409 T7411 arg2Of Observations,made
R6347 T7411 T7410 arg2Of made,were
R6348 T7411 T7419 arg1Of made,and
R6349 T7417 T7411 arg1Of lens,made
R6350 T7417 T7412 arg2Of lens,by
R6351 T7417 T7413 arg1Of lens,40×1.0
R6352 T7417 T7414 arg1Of lens,NA
R6353 T7417 T7415 arg1Of lens,oil-immersion
R6354 T7417 T7416 arg1Of lens,objective
R6355 T7419 T7418 arg1Of and,","
R6356 T7420 T7421 arg1Of fluorescence,and
R6357 T7422 T7421 arg2Of phase,and
R6358 T7424 T7420 arg1Of images,fluorescence
R6359 T7424 T7422 arg1Of images,phase
R6360 T7424 T7423 arg1Of images,contrast
R6361 T7424 T7425 arg1Of images,were
R6362 T7424 T7426 arg2Of images,gathered
R6363 T7426 T7419 arg2Of gathered,and
R6364 T7426 T7425 arg2Of gathered,were
R6365 T7426 T7427 modOf gathered,using
R6366 T7427 T7431 arg2Of using,charged
R6367 T7430 T7428 arg1Of ORCA-ER,a
R6368 T7430 T7429 arg1Of ORCA-ER,Hamamatsu
R6369 T7430 T7431 arg1Of ORCA-ER,charged
R6370 T7434 T7427 arg2Of camera,using
R6371 T7434 T7432 arg2Of camera,coupled
R6372 T7434 T7433 arg1Of camera,device
R6373 T7434 T7435 arg1Of camera,(
R6374 T7434 T7443 arg2Of camera,driven
R6375 T7436 T7435 arg2Of Bridgewater,(
R6376 T7436 T7437 arg1Of Bridgewater,","
R6377 T7439 T7437 arg2Of Jersey,","
R6378 T7439 T7438 arg1Of Jersey,New
R6379 T7439 T7440 arg1Of Jersey,","
R6380 T7441 T7440 arg2Of USA,","
R6381 T7442 T7435 arg3Of ),(
R6382 T7443 T7447 arg1Of driven,(
R6383 T7446 T7443 arg1Of software,driven
R6384 T7446 T7444 arg2Of software,by
R6385 T7446 T7445 arg1Of software,Openlab
R6386 T7448 T7449 arg1Of Improvision,","
R6387 T7449 T7447 arg2Of ",",(
R6388 T7449 T7451 arg1Of ",",","
R6389 T7450 T7449 arg2Of Coventry,","
R6390 T7452 T7451 arg2Of UK,","
R6391 T7453 T7447 arg3Of ),(
R6392 T7454 T7455 arg1Of Photographs,were
R6393 T7454 T7456 arg2Of Photographs,taken
R6394 T7456 T7455 arg2Of taken,were
R6395 T7456 T7457 arg1Of taken,at
R6396 T7458 T7459 arg1Of 0,","
R6397 T7459 T7461 arg1Of ",",","
R6398 T7460 T7459 arg2Of 30,","
R6399 T7461 T7463 arg1Of ",",","
R6400 T7462 T7461 arg2Of 60,","
R6401 T7463 T7466 arg1Of ",",and
R6402 T7464 T7463 arg2Of 120,","
R6403 T7466 T7465 arg1Of and,","
R6404 T7467 T7466 arg2Of 240,and
R6405 T7468 T7457 arg2Of min,at
R6406 T7468 T7458 arg1Of min,0
R6407 T7468 T7460 arg1Of min,30
R6408 T7468 T7462 arg1Of min,60
R6409 T7468 T7464 arg1Of min,120
R6410 T7468 T7467 arg1Of min,240
R6533 T7612 T7611 arg1Of Analysis,Densitometric
R6534 T7613 T7614 arg1Of Densitometry,of
R6535 T7613 T7617 arg1Of Densitometry,was
R6536 T7613 T7618 arg2Of Densitometry,performed
R6537 T7616 T7614 arg2Of immunoblots,of
R6538 T7616 T7615 arg1Of immunoblots,ECL
R6539 T7618 T7617 arg2Of performed,was
R6540 T7619 T7618 arg3Of using,performed
R6541 T7621 T7620 arg1Of ID,Gelworks
R6542 T7623 T7619 arg2Of software,using
R6543 T7623 T7621 arg1Of software,ID
R6544 T7623 T7622 arg1Of software,intermediate
R6545 T7623 T7624 arg1Of software,(
R6546 T7626 T7624 arg2Of Products,(
R6547 T7626 T7625 arg1Of Products,Ultraviolet
R6548 T7626 T7627 arg1Of Products,","
R6549 T7628 T7627 arg2Of Cambridgeshire,","
R6550 T7628 T7629 arg1Of Cambridgeshire,","
R6551 T7630 T7629 arg2Of UK,","
R6552 T7631 T7624 arg3Of ),(
R6553 T7634 T7635 arg1Of immunoblots,were
R6554 T7634 T7636 arg2Of immunoblots,scanned
R6555 T7636 T7635 arg2Of scanned,were
R6556 T7636 T7637 arg1Of scanned,and
R6557 T7637 T7632 arg1Of and,Briefly
R6558 T7637 T7633 arg1Of and,","
R6559 T7638 T7639 arg1Of gates,were
R6560 T7638 T7640 arg2Of gates,drawn
R6561 T7640 T7637 arg2Of drawn,and
R6562 T7640 T7639 arg2Of drawn,were
R6563 T7640 T7641 arg1Of drawn,tightly
R6564 T7640 T7642 arg1Of drawn,around
R6565 T7644 T7642 arg2Of band,around
R6566 T7644 T7643 arg1Of band,each
R6567 T7646 T7645 arg1Of values,Background
R6568 T7646 T7647 arg1Of values,from
R6572 T7649 T7647 arg2Of lane,from
R6604 T7679 T7686 arg2Of films,selected
R6605 T7682 T7680 arg2Of levels,generating
R6606 T7682 T7681 arg1Of levels,subsaturating
R6607 T7682 T7683 arg1Of levels,of
R6608 T7684 T7683 arg2Of intensity,of
R6609 T7686 T7677 arg2Of selected,and
R6610 T7686 T7685 arg2Of selected,were
R6611 T7686 T7687 arg1Of selected,for
R6612 T7689 T7687 arg2Of evaluation,for
R6613 T7689 T7688 arg1Of evaluation,densitometric
R6698 T7788 T7787 arg1Of Analysis,Statistical
R6699 T7789 T7790 arg1Of Data,from
R6700 T7789 T7796 arg1Of Data,are
R6701 T7789 T7797 arg2Of Data,presented
R6702 T7789 T7813 arg1Of Data,were
R6703 T7789 T7814 arg2Of Data,compared
R6704 T7789 T7815 arg1Of Data,using
R6705 T7791 T7792 arg1Of three,or
R6706 T7791 T7793 arg1Of three,more
R6707 T7795 T7790 arg2Of experiments,from
R6708 T7795 T7791 arg1Of experiments,three
R6709 T7795 T7794 arg1Of experiments,independent
R6710 T7797 T7796 arg2Of presented,are
R6711 T7797 T7798 arg1Of presented,as
R6712 T7797 T7812 arg1Of presented,and
R6713 T7801 T7798 arg2Of error,as
R6714 T7801 T7799 arg1Of error,the
R6715 T7801 T7800 arg1Of error,mean±standard
R6716 T7801 T7802 arg1Of error,of
R6717 T7801 T7808 arg1Of error,","
R6718 T7801 T7809 arg1Of error,except
R6719 T7801 T7811 arg2Of error,stated
R6720 T7804 T7802 arg2Of mean,of
R6721 T7804 T7803 arg1Of mean,the
R6722 T7804 T7805 arg1Of mean,(
R6723 T7806 T7805 arg2Of SEM,(
R6724 T7807 T7805 arg3Of ),(
R6725 T7811 T7810 arg1Of stated,where
R6726 T7814 T7812 arg2Of compared,and
R6727 T7814 T7813 arg2Of compared,were
R6728 T7815 T7814 arg3Of using,compared
R6729 T7815 T7821 arg1Of using,Software
R6730 T7815 T7825 arg1Of using,//www.graphpad.com
R6731 T7817 T7815 arg2Of Prism,using
R6732 T7817 T7816 arg1Of Prism,GraphPad
R6733 T7817 T7818 arg1Of Prism,4
R6734 T7821 T7820 arg1Of Software,GraphPad
R6735 T7821 T7822 arg1Of Software,","
R6736 T7822 T7819 arg1Of ",",(
R6737 T7822 T7826 arg1Of ",",)
R6738 T7823 T7824 arg1Of http,:
R6739 T7825 T7822 arg2Of //www.graphpad.com,","
R6740 T7825 T7823 arg1Of //www.graphpad.com,http
R6741 T7827 T7828 arg1Of Results,were
R6742 T7827 T7829 arg2Of Results,analysed
R6743 T7829 T7828 arg2Of analysed,were
R6744 T7829 T7830 modOf analysed,using
R6745 T7830 T7833 arg1Of using,with
R6746 T7832 T7830 arg2Of ANOVA,using
R6747 T7832 T7831 arg1Of ANOVA,one-way
R6748 T7834 T7833 arg2Of Newman-Keuls,with
R6749 T7836 T7835 arg1Of test,post
R6750 T7836 T7837 arg1Of test,except
R6751 T7836 T7859 arg2Of test,matched
R6752 T7836 T7861 arg2Of test,signed
R6753 T7837 T7838 arg1Of except,for
R6754 T7840 T7839 arg1Of data,the
R6755 T7840 T7841 arg1Of data,from
R6756 T7840 T7859 arg1Of data,matched
R6757 T7844 T7843 arg1Of vivo,in
R6758 T7845 T7844 arg1Of inhaled,vivo
R6759 T7847 T7841 arg2Of study,from
R6760 T7847 T7842 arg1Of study,the
R6761 T7847 T7845 arg1Of study,inhaled
R6762 T7847 T7846 arg1Of study,FP
R6763 T7847 T7848 arg1Of study,","
R6764 T7847 T7849 arg1Of study,which
R6765 T7847 T7850 arg1Of study,was
R6766 T7847 T7851 arg2Of study,analysed
R6767 T7851 T7850 arg2Of analysed,was
R6768 T7853 T7854 arg2Of Friedman,'s
R6769 T7855 T7851 arg1Of test,analysed
R6770 T7855 T7852 arg2Of test,by
R6771 T7855 T7854 arg1Of test,'s
R6772 T7855 T7856 arg1Of test,with
R6773 T7858 T7856 arg2Of Wilcoxson,with
R6774 T7858 T7857 arg1Of Wilcoxson,subsequent
R6775 T7860 T7861 arg1Of pair,signed
R6776 T7861 T7828 modOf signed,were
R6777 T7864 T7861 arg3Of test,signed
R6778 T7864 T7862 arg1Of test,rank
R6779 T7864 T7863 arg1Of test,sum
R6780 T7865 T7866 arg1Of Data,from
R6781 T7865 T7869 arg1Of Data,are
R6782 T7865 T7870 arg2Of Data,presented
R6783 T7868 T7866 arg2Of analysis,from
R6784 T7868 T7867 arg1Of analysis,this
R6785 T7870 T7869 arg2Of presented,are
R6786 T7870 T7871 arg1Of presented,as
R6787 T7874 T7871 arg2Of plot,as
R6788 T7874 T7872 arg1Of plot,a
R6789 T7874 T7873 arg1Of plot,box-and-whiskers
R6790 T7875 T7876 arg2Of Friedman,'s
R6791 T7877 T7876 arg1Of test,'s
R6792 T7877 T7878 arg1Of test,was
R6793 T7877 T7879 arg2Of test,used
R6794 T7879 T7878 arg2Of used,was
R6795 T7879 T7880 arg1Of used,as
R6796 T7883 T7881 arg1Of measures,three
R6797 T7883 T7882 arg1Of measures,matched
R6798 T7883 T7884 arg1Of measures,were
R6799 T7883 T7885 arg2Of measures,obtained
R6800 T7883 T7886 arg1Of measures,using
R6801 T7885 T7880 arg2Of obtained,as
R6802 T7885 T7884 arg2Of obtained,were
R6803 T7886 T7885 arg3Of using,obtained
R6804 T7887 T7888 arg1Of placebo,","
R6805 T7888 T7892 arg1Of ",",and
R6806 T7890 T7888 arg2Of µg,","
R6807 T7890 T7889 arg1Of µg,100
R6808 T7892 T7886 arg2Of and,using
R6809 T7892 T7891 arg1Of and,","
R6810 T7894 T7892 arg2Of µg,and
R6811 T7894 T7893 arg1Of µg,500
R6812 T7894 T7895 arg1Of µg,of
R6813 T7894 T7898 arg1Of µg,","
R6814 T7894 T7899 arg1Of µg,which
R6815 T7894 T7900 arg1Of µg,had
R6816 T7897 T7895 arg2Of FP,of
R6817 T7897 T7896 arg2Of FP,inhaled
R6818 T7903 T7900 arg2Of levels,had
R6819 T7903 T7901 arg1Of levels,variable
R6820 T7903 T7902 arg1Of levels,baseline
R6821 T7904 T7905 arg1Of We,did
R6822 T7904 T7907 arg1Of We,assume
R6823 T7907 T7905 arg2Of assume,did
R6824 T7907 T7906 arg1Of assume,not
R6825 T7910 T7907 arg2Of distribution,assume
R6826 T7910 T7908 arg1Of distribution,a
R6827 T7910 T7909 arg1Of distribution,Gaussian
R6828 T7910 T7911 arg1Of distribution,of
R6829 T7910 T7922 arg1Of distribution,(
R6830 T7913 T7911 arg2Of data,of
R6831 T7913 T7912 arg1Of data,the
R6832 T7913 T7914 arg1Of data,due
R6833 T7914 T7915 arg1Of due,to
R6834 T7918 T7915 arg2Of numbers,to
R6835 T7918 T7916 arg1Of numbers,the
R6836 T7918 T7917 arg1Of numbers,limited
R6837 T7918 T7919 arg1Of numbers,of
R6838 T7920 T7919 arg2Of participants,of
R6839 T7920 T7921 arg2Of participants,analysed
R6840 T7923 T7922 arg2Of seven,(
R6841 T7924 T7922 arg3Of ),(
R6842 T7927 T7925 arg1Of hypothesis,.The
R6843 T7927 T7926 arg1Of hypothesis,null
R6844 T7927 T7928 arg1Of hypothesis,was
R6845 T7927 T7929 arg2Of hypothesis,rejected
R6846 T7929 T7907 arg3Of rejected,assume
R6847 T7929 T7928 arg2Of rejected,was
R6848 T7929 T7930 arg1Of rejected,at
R6849 T7933 T7930 arg2Of 0.05,at
R6850 T7933 T7931 arg1Of 0.05,p
R6851 T7933 T7932 arg1Of 0.05,<
R7117 T8246 T8245 arg1Of Effect,The
R7118 T8246 T8247 arg1Of Effect,of
R7119 T8246 T8249 arg1Of Effect,on
R7120 T8248 T8247 arg2Of Corticosteroids,of
R7121 T8252 T8250 arg1Of Translocation,GATA-3
R7122 T8252 T8251 arg1Of Translocation,Nuclear
R7123 T8252 T8253 arg1Of Translocation,and
R7124 T8253 T8249 arg2Of and,on
R7125 T8255 T8253 arg2Of mRNA,and
R7126 T8255 T8254 arg1Of mRNA,IL-4
R7127 T8256 T8257 arg1Of Corticosteroids,are
R7128 T8256 T8258 arg1Of Corticosteroids,effective
R7129 T8258 T8257 arg2Of effective,are
R7130 T8258 T8259 arg1Of effective,in
R7131 T8260 T8259 arg2Of inhibiting,in
R7132 T8260 T8270 arg1Of inhibiting,[
R7133 T8264 T8260 arg2Of expression,inhibiting
R7134 T8264 T8261 arg1Of expression,GATA-3-regulated
R7135 T8264 T8262 arg1Of expression,IL-4
R7136 T8264 T8263 arg1Of expression,gene
R7137 T8264 T8266 arg1Of expression,vitro
R7138 T8264 T8269 arg1Of expression,vivo
R7139 T8266 T8265 arg1Of vitro,in
R7140 T8266 T8267 arg1Of vitro,and
R7141 T8269 T8267 arg2Of vivo,and
R7142 T8269 T8268 arg1Of vivo,in
R7143 T8271 T8270 arg2Of 32,[
R7144 T8272 T8270 arg3Of ],[
R7145 T8273 T8275 arg1Of We,investigated
R7146 T8275 T8274 arg1Of investigated,therefore
R7147 T8277 T8278 arg1Of corticosteroids,affect
R7148 T8278 T8275 arg2Of affect,investigated
R7149 T8278 T8276 arg1Of affect,whether
R7150 T8281 T8278 arg2Of import,affect
R7151 T8281 T8279 arg1Of import,anti-CD3/CD28–stimulated
R7152 T8281 T8280 arg1Of import,nuclear
R7153 T8281 T8282 arg1Of import,of
R7154 T8283 T8282 arg2Of GATA-3,of
R7155 T8284 T8285 arg1Of Stimulation,of
R7156 T8284 T8287 arg1Of Stimulation,with
R7157 T8284 T8289 arg1Of Stimulation,resulted
R7158 T8286 T8285 arg2Of cells,of
R7159 T8288 T8287 arg2Of anti-CD3/CD28,with
R7160 T8289 T8290 arg1Of resulted,in
R7161 T8289 T8300 arg1Of resulted,","
R7162 T8289 T8301 modOf resulted,confirming
R7163 T8289 T8305 arg1Of resulted,[
R7164 T8295 T8290 arg2Of translocation,in
R7165 T8295 T8291 arg1Of translocation,a
R7166 T8295 T8292 arg1Of translocation,rapid
R7167 T8295 T8293 arg1Of translocation,cytoplasmic/nuclear
R7168 T8295 T8294 arg1Of translocation,GATA-3
R7169 T8295 T8296 arg1Of translocation,(
R7170 T8298 T8296 arg2Of 1A,(
R7171 T8298 T8297 arg1Of 1A,Figure
R7172 T8299 T8296 arg3Of ),(
R7173 T8304 T8301 arg2Of results,confirming
R7174 T8304 T8302 arg1Of results,our
R7175 T8304 T8303 arg1Of results,previous
R7176 T8306 T8305 arg2Of 12,[
R7177 T8307 T8305 arg3Of ],[
R7178 T8308 T8310 arg1Of We,confirmed
R7179 T8310 T8309 arg1Of confirmed,also
R7180 T8310 T8319 arg1Of confirmed,as
R7181 T8313 T8310 arg2Of separation,confirmed
R7182 T8313 T8311 arg1Of separation,a
R7183 T8313 T8312 arg1Of separation,clear
R7184 T8313 T8314 arg1Of separation,of
R7185 T8315 T8316 arg1Of nuclear,and
R7186 T8317 T8316 arg2Of cytosolic,and
R7187 T8318 T8314 arg2Of fractions,of
R7188 T8318 T8315 arg1Of fractions,nuclear
R7189 T8318 T8317 arg1Of fractions,cytosolic
R7190 T8320 T8319 arg2Of indicated,as
R7191 T8323 T8322 arg1Of H1,histone
R7192 T8323 T8324 arg1Of H1,and
R7193 T8324 T8320 arg1Of and,indicated
R7194 T8324 T8321 arg2Of and,by
R7195 T8326 T8324 arg2Of markers,and
R7196 T8326 T8325 arg1Of markers,MEK-1
R7197 T8326 T8327 arg1Of markers,(
R7198 T8329 T8327 arg2Of 1B,(
R7199 T8329 T8328 arg1Of 1B,Figure
R7200 T8330 T8327 arg3Of ),(
R7201 T8335 T8331 arg1Of FP,The
R7202 T8335 T8332 arg1Of FP,potent
R7203 T8335 T8333 arg1Of FP,topical
R7204 T8335 T8334 arg1Of FP,corticosteroid
R7205 T8335 T8336 arg1Of FP,caused
R7206 T8338 T8336 arg2Of loss,caused
R7207 T8338 T8337 arg1Of loss,sustained
R7208 T8338 T8339 arg1Of loss,of
R7209 T8342 T8340 arg1Of expression,nuclear
R7210 T8342 T8341 arg1Of expression,GATA-3
R7211 T8342 T8343 arg1Of expression,and
R7212 T8343 T8339 arg2Of and,of
R7213 T8343 T8348 arg1Of and,at
R7214 T8345 T8343 arg2Of retention,and
R7215 T8345 T8344 arg1Of retention,cytoplasmic
R7216 T8345 T8346 arg1Of retention,of
R7217 T8347 T8346 arg2Of GATA-3,of
R7218 T8349 T8348 arg2Of concentrations,at
R7219 T8349 T8350 arg1Of concentrations,ranging
R7220 T8350 T8351 arg1Of ranging,from
R7221 T8352 T8353 arg1Of 10−12,to
R7222 T8354 T8353 arg2Of 10−8,to
R7223 T8355 T8351 arg2Of M,from
R7224 T8355 T8352 arg1Of M,10−12
R7225 T8355 T8356 arg1Of M,","
R7226 T8355 T8357 arg1Of M,which
R7227 T8355 T8358 arg1Of M,cover
R7228 T8361 T8358 arg2Of range,cover
R7229 T8361 T8359 arg1Of range,the
R7230 T8361 T8360 arg1Of range,therapeutic
R7231 T8361 T8362 arg1Of range,[
R7232 T8363 T8362 arg2Of 37,[
R7233 T8364 T8362 arg3Of ],[
R7234 T8366 T8365 arg1Of effect,This
R7235 T8366 T8367 arg1Of effect,was
R7236 T8366 T8368 arg1Of effect,concentration-
R7237 T8366 T8370 arg1Of effect,time-dependent
R7238 T8366 T8392 arg1Of effect,was
R7239 T8366 T8393 arg2Of effect,associated
R7240 T8367 T8371 arg1Of was,","
R7241 T8367 T8372 arg1Of was,with
R7242 T8367 T8391 arg1Of was,and
R7243 T8368 T8369 arg1Of concentration-,and
R7244 T8369 T8367 arg2Of and,was
R7245 T8370 T8369 arg2Of time-dependent,and
R7246 T8375 T8372 arg2Of effect,with
R7247 T8375 T8373 arg1Of effect,a
R7248 T8375 T8374 arg1Of effect,peak
R7249 T8375 T8376 arg1Of effect,of
R7250 T8375 T8381 arg1Of effect,at
R7251 T8379 T8377 arg1Of 30,11.6-fold
R7252 T8379 T8378 arg1Of 30,at
R7253 T8380 T8376 arg2Of min,of
R7254 T8380 T8379 arg1Of min,30
R7255 T8383 T8381 arg2Of concentration,at
R7256 T8383 T8382 arg1Of concentration,a
R7257 T8383 T8384 arg1Of concentration,of
R7258 T8386 T8384 arg2Of M,of
R7259 T8386 T8385 arg1Of M,10−8
R7260 T8386 T8387 arg1Of M,(
R7261 T8389 T8387 arg2Of 1C,(
R7262 T8389 T8388 arg1Of 1C,Figure
R7263 T8390 T8387 arg3Of ),(
R7264 T8393 T8391 arg2Of associated,and
R7265 T8393 T8392 arg2Of associated,was
R7266 T8393 T8394 arg1Of associated,with
R7267 T8396 T8394 arg2Of reductions,with
R7268 T8396 T8395 arg1Of reductions,marked
R7269 T8396 T8397 arg1Of reductions,in
R7270 T8399 T8400 arg1Of IL-4,and
R7271 T8401 T8400 arg2Of IL-5,and
R7272 T8403 T8398 arg1Of expression,anti-CD3/CD28–stimulated
R7273 T8403 T8399 arg1Of expression,IL-4
R7274 T8403 T8401 arg1Of expression,IL-5
R7275 T8403 T8402 arg1Of expression,mRNA
R7276 T8403 T8404 arg1Of expression,(
R7277 T8403 T8408 arg1Of expression,and
R7278 T8406 T8404 arg2Of 1D,(
R7279 T8406 T8405 arg1Of 1D,Figure
R7280 T8407 T8404 arg3Of ),(
R7281 T8408 T8397 arg2Of and,in
R7282 T8410 T8408 arg2Of loss,and
R7283 T8410 T8409 arg1Of loss,a
R7284 T8410 T8411 arg1Of loss,of
R7285 T8410 T8414 arg1Of loss,to
R7286 T8413 T8411 arg2Of binding,of
R7287 T8413 T8412 arg1Of binding,GATA-3
R7288 T8418 T8414 arg2Of promoter,to
R7289 T8418 T8415 arg1Of promoter,the
R7290 T8418 T8416 arg1Of promoter,native
R7291 T8418 T8417 arg1Of promoter,IL-5
R7292 T8418 T8419 arg1Of promoter,(
R7293 T8421 T8419 arg2Of 1E,(
R7294 T8421 T8420 arg1Of 1E,Figure
R7295 T8422 T8419 arg3Of ),(
R7701 T8947 T8946 arg1Of GR,Ligand-Activated
R7702 T8947 T8948 arg1Of GR,Competes
R7703 T8948 T8949 arg1Of Competes,with
R7704 T8950 T8949 arg2Of GATA-3,with
R7705 T8950 T8951 arg1Of GATA-3,for
R7706 T8952 T8951 arg2Of Importin-α,for
R7707 T8953 T8954 arg1Of We,confirmed
R7708 T8953 T8956 arg1Of We,extended
R7709 T8954 T8955 arg1Of confirmed,and
R7710 T8956 T8955 arg2Of extended,and
R7711 T8958 T8954 arg2Of data,confirmed
R7712 T8958 T8956 arg2Of data,extended
R7713 T8958 T8957 arg1Of data,previous
R7714 T8958 T8959 arg1Of data,[
R7715 T8958 T8962 modOf data,to
R7716 T8958 T8963 arg1Of data,show
R7717 T8958 T8972 arg1Of data,importin-α
R7718 T8958 T8977 arg1Of data,(
R7719 T8960 T8959 arg2Of 20,[
R7720 T8961 T8959 arg3Of ],[
R7721 T8963 T8962 arg1Of show,to
R7722 T8966 T8965 arg1Of GR,ligand-activated
R7723 T8966 T8969 arg1Of GR,as
R7724 T8969 T8967 arg1Of as,as
R7725 T8969 T8968 arg1Of as,well
R7726 T8969 T8971 arg1Of as,uses
R7727 T8970 T8969 arg2Of GATA-3,as
R7728 T8971 T8963 arg2Of uses,show
R7729 T8971 T8964 arg1Of uses,that
R7730 T8972 T8973 arg1Of importin-α,for
R7731 T8976 T8973 arg2Of import,for
R7732 T8976 T8974 arg1Of import,its
R7733 T8976 T8975 arg1Of import,nuclear
R7734 T8979 T8978 arg1Of 2A,Figure
R7735 T8979 T8980 arg1Of 2A,and
R7736 T8980 T8977 arg2Of and,(
R7737 T8981 T8980 arg2Of 2B,and
R7738 T8982 T8977 arg3Of ),(
R7739 T8984 T8983 arg1Of interaction,This
R7740 T8984 T8985 arg1Of interaction,between
R7741 T8984 T8989 arg1Of interaction,was
R7742 T8984 T8990 arg1Of interaction,significant
R7743 T8984 T8999 arg1Of interaction,was
R7744 T8984 T9000 arg1Of interaction,maximal
R7745 T8986 T8987 arg1Of GR,and
R7746 T8987 T8985 arg2Of and,between
R7747 T8988 T8987 arg2Of importin-α,and
R7748 T8989 T8991 arg1Of was,at
R7749 T8989 T8998 arg1Of was,and
R7750 T8990 T8989 arg2Of significant,was
R7751 T8992 T8991 arg2Of concentrations,at
R7752 T8992 T8994 arg1Of concentrations,low
R7753 T8994 T8993 arg1Of low,as
R7754 T8994 T8995 arg1Of low,as
R7755 T8997 T8995 arg2Of M,as
R7756 T8997 T8996 arg1Of M,10−12
R7757 T8999 T8998 arg2Of was,and
R7758 T9000 T8999 arg2Of maximal,was
R7759 T9000 T9001 arg1Of maximal,with
R7760 T9002 T9003 arg1Of 10−8,M
R7761 T9004 T9001 arg2Of FP,with
R7762 T9004 T9002 arg1Of FP,10−8
R7763 T9008 T9005 arg1Of translocation,Subsequent
R7764 T9008 T9006 arg1Of translocation,GR
R7765 T9008 T9007 arg1Of translocation,nuclear
R7766 T9008 T9009 arg1Of translocation,was
R7767 T9008 T9010 arg1Of translocation,rapid
R7768 T9008 T9012 arg1Of translocation,sustained
R7769 T9009 T9013 arg1Of was,at
R7770 T9009 T9016 arg1Of was,for
R7771 T9010 T9011 arg1Of rapid,and
R7772 T9011 T9009 arg2Of and,was
R7773 T9012 T9011 arg2Of sustained,and
R7774 T9015 T9013 arg2Of levels,at
R7775 T9015 T9014 arg1Of levels,significant
R7776 T9019 T9017 arg1Of 14,at
R7777 T9019 T9018 arg1Of 14,least
R7778 T9020 T9016 arg2Of h,for
R7779 T9020 T9019 arg1Of h,14
R7780 T9020 T9021 arg1Of h,(
R7781 T9023 T9021 arg2Of 2B,(
R7782 T9023 T9022 arg1Of 2B,Figure
R7783 T9024 T9021 arg3Of ),(
R7784 T9027 T9025 arg2Of blotting,Using
R7785 T9027 T9026 arg1Of blotting,IP-Western
R7786 T9028 T9025 arg1Of we,Using
R7787 T9028 T9029 arg1Of we,showed
R7788 T9029 T9025 modOf showed,Using
R7789 T9031 T9032 arg1Of FP,at
R7790 T9031 T9035 arg1Of FP,decreased
R7791 T9034 T9032 arg2Of M,at
R7792 T9034 T9033 arg1Of M,10−12–10−8
R7793 T9035 T9029 arg2Of decreased,showed
R7794 T9035 T9030 arg1Of decreased,that
R7795 T9037 T9035 arg2Of association,decreased
R7796 T9037 T9036 arg1Of association,the
R7797 T9037 T9038 arg1Of association,between
R7798 T9039 T9040 arg1Of GATA-3,and
R7799 T9040 T9038 arg2Of and,between
R7800 T9040 T9042 arg2Of and,induced
R7801 T9041 T9040 arg2Of importin-α,and
R7802 T9045 T9042 arg1Of stimulation,induced
R7803 T9045 T9043 arg2Of stimulation,by
R7804 T9045 T9044 arg1Of stimulation,anti-CD3/CD28
R7805 T9045 T9046 arg1Of stimulation,in
R7806 T9049 T9046 arg2Of manner,in
R7807 T9049 T9047 arg1Of manner,a
R7808 T9049 T9048 arg1Of manner,concentration-dependent
R7809 T9049 T9050 arg1Of manner,(
R7810 T9052 T9050 arg2Of 2C,(
R7811 T9052 T9051 arg1Of 2C,Figure
R7812 T9053 T9050 arg3Of ),(
R7813 T9055 T9054 arg2Of addition,In
R7814 T9059 T9058 arg1Of GATA-3,GFP-labelled
R7815 T9059 T9060 arg1Of GATA-3,and
R7816 T9060 T9057 arg2Of and,using
R7817 T9062 T9060 arg2Of microscopy,and
R7818 T9062 T9061 arg1Of microscopy,confocal
R7819 T9063 T9064 arg1Of we,demonstrated
R7820 T9064 T9054 arg1Of demonstrated,In
R7821 T9064 T9056 arg1Of demonstrated,","
R7822 T9064 T9057 modOf demonstrated,using
R7823 T9068 T9066 arg1Of import,GATA-3
R7824 T9068 T9067 arg1Of import,nuclear
R7825 T9068 T9069 arg1Of import,following
R7826 T9068 T9075 arg1Of import,was
R7827 T9068 T9076 arg2Of import,attenuated
R7828 T9071 T9069 arg2Of stimulation,following
R7829 T9071 T9070 arg1Of stimulation,anti-CD3/CD28
R7830 T9071 T9072 arg1Of stimulation,for
R7831 T9074 T9072 arg2Of min,for
R7832 T9074 T9073 arg1Of min,30
R7833 T9076 T9064 arg2Of attenuated,demonstrated
R7834 T9076 T9065 arg1Of attenuated,that
R7835 T9076 T9075 arg2Of attenuated,was
R7836 T9078 T9076 arg1Of pretreatment,attenuated
R7837 T9078 T9077 arg2Of pretreatment,by
R7838 T9078 T9079 arg1Of pretreatment,with
R7839 T9080 T9079 arg2Of FP,with
R7840 T9080 T9081 arg1Of FP,(
R7841 T9080 T9085 arg1Of FP,(
R7842 T9083 T9081 arg2Of M,(
R7843 T9083 T9082 arg1Of M,10−8
R7844 T9084 T9081 arg3Of ),(
R7845 T9087 T9085 arg2Of 2D,(
R7846 T9087 T9086 arg1Of 2D,Figure
R7847 T9088 T9085 arg3Of ),(
R8309 T9702 T9703 arg1Of Effect,on
R8310 T9704 T9703 arg2Of MKP-1,on
R8311 T9705 T9706 arg1Of Dexamethasone,inhibits
R8312 T9706 T9710 arg1Of inhibits,in
R8313 T9706 T9715 arg1Of inhibits,through
R8314 T9706 T9730 arg1Of inhibits,and
R8315 T9709 T9706 arg2Of function,inhibits
R8316 T9709 T9707 arg1Of function,p38
R8317 T9709 T9708 arg1Of function,MAPK
R8318 T9714 T9710 arg2Of manner,in
R8319 T9714 T9711 arg1Of manner,a
R8320 T9714 T9712 arg1Of manner,cell
R8321 T9714 T9713 arg1Of manner,type–specific
R8322 T9718 T9715 arg2Of induction,through
R8323 T9718 T9716 arg1Of induction,the
R8324 T9718 T9717 arg1Of induction,rapid
R8325 T9718 T9719 arg1Of induction,of
R8326 T9724 T9719 arg2Of MKP-1,of
R8327 T9724 T9720 arg1Of MKP-1,the
R8328 T9724 T9721 arg1Of MKP-1,dual
R8329 T9724 T9722 arg1Of MKP-1,kinase
R8330 T9724 T9723 arg1Of MKP-1,phosphatase
R8331 T9724 T9725 arg1Of MKP-1,(
R8332 T9727 T9725 arg2Of phosphatase-1,(
R8333 T9727 T9726 arg1Of phosphatase-1,MAPK
R8334 T9728 T9725 arg3Of ),(
R8335 T9730 T9729 arg1Of and,","
R8336 T9732 T9731 arg1Of effect,this
R8337 T9732 T9733 arg1Of effect,lasts
R8338 T9733 T9730 arg2Of lasts,and
R8339 T9733 T9734 arg1Of lasts,for
R8340 T9733 T9739 arg1Of lasts,[
R8341 T9737 T9735 arg1Of 24,up
R8342 T9737 T9736 arg1Of 24,to
R8343 T9738 T9734 arg2Of h,for
R8344 T9738 T9737 arg1Of h,24
R8345 T9740 T9739 arg2Of 28,[
R8346 T9741 T9739 arg3Of ],[
R8347 T9742 T9743 arg1Of FP,(
R8348 T9745 T9743 arg2Of M,(
R8349 T9745 T9744 arg1Of M,10−8
R8350 T9746 T9743 arg3Of ),(
R8351 T9747 T9742 arg1Of treatment,FP
R8352 T9747 T9748 arg1Of treatment,of
R8353 T9747 T9757 arg1Of treatment,decreased
R8354 T9750 T9748 arg2Of cells,of
R8355 T9750 T9749 arg1Of cells,HuT-78
R8356 T9750 T9751 arg2Of cells,activated
R8357 T9751 T9755 arg1Of activated,vitro
R8358 T9753 T9751 arg1Of anti-CD3/CD28,activated
R8359 T9753 T9752 arg2Of anti-CD3/CD28,by
R8360 T9755 T9754 arg1Of vitro,in
R8361 T9757 T9756 arg1Of decreased,significantly
R8362 T9760 T9758 arg1Of phosphorylation,p38
R8363 T9760 T9759 arg1Of phosphorylation,MAPK
R8364 T9760 T9761 arg1Of phosphorylation,(
R8365 T9760 T9765 arg1Of phosphorylation,and
R8366 T9763 T9761 arg2Of 3A,(
R8367 T9763 T9762 arg1Of 3A,Figure
R8368 T9764 T9761 arg3Of ),(
R8369 T9765 T9757 arg2Of and,decreased
R8370 T9766 T9765 arg2Of activity,and
R8371 T9766 T9767 arg2Of activity,measured
R8372 T9769 T9767 arg1Of phosphorylation,measured
R8373 T9769 T9768 arg2Of phosphorylation,by
R8374 T9769 T9770 arg1Of phosphorylation,of
R8375 T9774 T9770 arg2Of ATF-2,of
R8376 T9774 T9771 arg1Of ATF-2,the
R8377 T9774 T9772 arg1Of ATF-2,downstream
R8378 T9774 T9773 arg1Of ATF-2,target
R8379 T9774 T9775 arg1Of ATF-2,(
R8380 T9777 T9775 arg2Of 3B,(
R8381 T9777 T9776 arg1Of 3B,Figure
R8382 T9778 T9775 arg3Of ),(
R8383 T9780 T9779 arg1Of effect,This
R8384 T9780 T9781 arg1Of effect,was
R8385 T9780 T9782 arg2Of effect,detected
R8386 T9780 T9787 arg2Of effect,lasted
R8387 T9782 T9783 arg1Of detected,at
R8388 T9782 T9786 arg1Of detected,and
R8389 T9785 T9783 arg2Of min,at
R8390 T9785 T9784 arg1Of min,30
R8391 T9786 T9781 arg2Of and,was
R8392 T9787 T9786 arg2Of lasted,and
R8393 T9787 T9788 arg1Of lasted,for
R8394 T9791 T9789 arg1Of 14,at
R8395 T9791 T9790 arg1Of 14,least
R8396 T9792 T9788 arg2Of h,for
R8397 T9792 T9791 arg1Of h,14
R8398 T9792 T9793 arg1Of h,(
R8399 T9795 T9793 arg2Of 3B,(
R8400 T9795 T9794 arg1Of 3B,Figure
R8401 T9796 T9793 arg3Of ),(
R8402 T9797 T9798 arg1Of FP,(
R8403 T9797 T9804 arg1Of FP,reduced
R8404 T9800 T9798 arg2Of M,(
R8405 T9800 T9799 arg1Of M,10−8
R8406 T9801 T9798 arg3Of ),(
R8407 T9804 T9802 arg1Of reduced,also
R8408 T9804 T9803 arg1Of reduced,significantly
R8409 T9807 T9804 arg2Of phosphorylation,reduced
R8410 T9807 T9805 arg1Of phosphorylation,GATA-3
R8411 T9807 T9806 arg1Of phosphorylation,serine
R8412 T9807 T9808 arg2Of phosphorylation,induced
R8413 T9811 T9808 arg1Of stimulation,induced
R8414 T9811 T9809 arg2Of stimulation,by
R8415 T9811 T9810 arg1Of stimulation,anti-CD3/CD28
R8416 T9811 T9812 arg1Of stimulation,in
R8417 T9815 T9816 arg1Of time-,and
R8418 T9817 T9816 arg2Of concentration-dependent,and
R8419 T9818 T9812 arg2Of manner,in
R8420 T9818 T9813 arg1Of manner,both
R8421 T9818 T9814 arg1Of manner,a
R8422 T9818 T9815 arg1Of manner,time-
R8423 T9818 T9817 arg1Of manner,concentration-dependent
R8424 T9818 T9819 arg1Of manner,(
R8425 T9821 T9819 arg2Of 3C,(
R8426 T9821 T9820 arg1Of 3C,Figure
R8427 T9822 T9819 arg3Of ),(
R8428 T9824 T9823 arg1Of reduction,This
R8429 T9824 T9825 arg1Of reduction,in
R8430 T9824 T9828 arg1Of reduction,was
R8431 T9824 T9830 arg2Of reduction,seen
R8432 T9827 T9825 arg2Of phosphorylation,in
R8433 T9827 T9826 arg1Of phosphorylation,GATA-3
R8434 T9830 T9828 arg2Of seen,was
R8435 T9830 T9829 arg1Of seen,also
R8436 T9830 T9831 arg1Of seen,with
R8437 T9833 T9831 arg2Of concentrations,with
R8438 T9833 T9832 arg1Of concentrations,lower
R8439 T9833 T9834 arg1Of concentrations,of
R8440 T9835 T9834 arg2Of FP,of
R8441 T9836 T9837 arg1Of We,found
R8442 T9839 T9841 arg1Of FP,induced
R8443 T9841 T9837 arg2Of induced,found
R8444 T9841 T9838 arg1Of induced,that
R8445 T9841 T9840 arg1Of induced,significantly
R8446 T9841 T9844 arg1Of induced,in
R8447 T9841 T9851 arg1Of induced,","
R8448 T9843 T9841 arg2Of mRNA,induced
R8449 T9843 T9842 arg1Of mRNA,MKP-1
R8450 T9847 T9848 arg1Of time-,and
R8451 T9849 T9848 arg2Of concentration-dependent,and
R8452 T9850 T9844 arg2Of manner,in
R8453 T9850 T9845 arg1Of manner,both
R8454 T9850 T9846 arg1Of manner,a
R8455 T9850 T9847 arg1Of manner,time-
R8456 T9850 T9849 arg1Of manner,concentration-dependent
R8457 T9852 T9841 arg3Of reaching,induced
R8458 T9852 T9855 arg1Of reaching,at
R8459 T9852 T9858 arg1Of reaching,after
R8460 T9854 T9852 arg2Of plateau,reaching
R8461 T9854 T9853 arg1Of plateau,a
R8462 T9857 T9855 arg2Of M,at
R8463 T9857 T9856 arg1Of M,10−8
R8464 T9860 T9858 arg2Of min,after
R8465 T9860 T9859 arg1Of min,10
R8466 T9860 T9861 arg1Of min,(
R8467 T9863 T9862 arg1Of 3D,Figure
R8468 T9863 T9864 arg1Of 3D,and
R8469 T9864 T9861 arg2Of and,(
R8470 T9865 T9864 arg2Of 3E,and
R8471 T9866 T9861 arg3Of ),(
R8472 T9870 T9869 arg1Of effects,the
R8473 T9870 T9871 arg1Of effects,of
R8474 T9870 T9873 arg1Of effects,on
R8475 T9870 T9884 arg1Of effects,are
R8476 T9870 T9885 arg2Of effects,seen
R8477 T9872 T9871 arg2Of FP,of
R8478 T9876 T9874 arg1Of import,GATA-3
R8479 T9876 T9875 arg1Of import,nuclear
R8480 T9876 T9877 arg1Of import,","
R8481 T9877 T9880 arg1Of ",",and
R8482 T9879 T9877 arg2Of association,","
R8483 T9879 T9878 arg1Of association,importin-α
R8484 T9880 T9873 arg2Of and,on
R8485 T9883 T9880 arg2Of expression,and
R8486 T9883 T9881 arg1Of expression,IL-4
R8487 T9883 T9882 arg1Of expression,mRNA
R8488 T9885 T9867 arg1Of seen,However
R8489 T9885 T9868 arg1Of seen,","
R8490 T9885 T9884 arg2Of seen,are
R8491 T9885 T9886 arg1Of seen,at
R8492 T9888 T9887 arg1Of lower,"10,000-fold"
R8493 T9889 T9886 arg2Of concentrations,at
R8494 T9889 T9888 arg1Of concentrations,lower
R8495 T9889 T9890 arg1Of concentrations,(
R8496 T9892 T9891 arg1Of M,10−12
R8497 T9892 T9894 arg1Of M,see
R8498 T9894 T9890 arg2Of see,(
R8499 T9894 T9893 arg1Of see,","
R8500 T9895 T9894 arg2Of Figure,see
R8501 T9895 T9896 arg1Of Figure,2
R8502 T9897 T9890 arg3Of ),(
R8503 T9898 T9908 modOf Using,utilizing
R8504 T9901 T9900 arg1Of vitro,in
R8505 T9903 T9898 arg2Of assay,Using
R8506 T9903 T9899 arg1Of assay,an
R8507 T9903 T9901 arg1Of assay,vitro
R8508 T9903 T9902 arg1Of assay,competition
R8509 T9903 T9904 arg1Of assay,(
R8510 T9906 T9904 arg2Of 4A,(
R8511 T9906 T9905 arg1Of 4A,Figure
R8512 T9907 T9904 arg3Of ),(
R8513 T9911 T9909 arg2Of GATA-3,purified
R8514 T9911 T9910 arg2Of GATA-3,activated
R8515 T9911 T9912 arg1Of GATA-3,","
R8516 T9912 T9915 arg1Of ",",and
R8517 T9913 T9912 arg2Of importin-α,","
R8518 T9915 T9908 arg2Of and,utilizing
R8519 T9915 T9914 arg1Of and,","
R8520 T9917 T9915 arg2Of GR,and
R8521 T9917 T9916 arg2Of GR,activated
R8522 T9919 T9920 arg1Of we,demonstrated
R8523 T9920 T9898 modOf demonstrated,Using
R8524 T9920 T9918 arg1Of demonstrated,","
R8525 T9923 T9922 arg2Of GR,activated
R8526 T9923 T9925 arg1Of GR,increased
R8527 T9925 T9920 arg2Of increased,demonstrated
R8528 T9925 T9921 arg1Of increased,that
R8529 T9925 T9924 arg1Of increased,significantly
R8530 T9925 T9928 arg1Of increased,in
R8531 T9927 T9925 arg2Of association,increased
R8532 T9927 T9926 arg1Of association,GR-importin-α
R8533 T9930 T9931 arg1Of presence,and
R8534 T9931 T9928 arg2Of and,in
R8535 T9931 T9929 arg1Of and,the
R8536 T9932 T9931 arg2Of absence,and
R8537 T9935 T9925 arg3Of GATA-3,increased
R8538 T9935 T9933 arg1Of GATA-3,of
R8539 T9935 T9934 arg2Of GATA-3,activated
R8540 T9935 T9936 arg1Of GATA-3,(
R8541 T9938 T9936 arg2Of 4B,(
R8542 T9938 T9937 arg1Of 4B,Figure
R8543 T9939 T9936 arg3Of ),(
R8544 T9941 T9940 arg1Of effect,This
R8545 T9941 T9942 arg1Of effect,is
R8546 T9942 T9943 arg1Of is,not
R8547 T9944 T9945 arg1Of mutual,","
R8548 T9944 T9946 arg1Of mutual,since
R8549 T9947 T9946 arg2Of activated,since
R8550 T9948 T9944 arg1Of GATA-3,mutual
R8551 T9948 T9949 arg1Of GATA-3,did
R8552 T9948 T9951 arg1Of GATA-3,block
R8553 T9951 T9942 arg2Of block,is
R8554 T9951 T9949 arg2Of block,did
R8555 T9951 T9950 arg1Of block,not
R8556 T9953 T9951 arg2Of association,block
R8557 T9953 T9952 arg1Of association,GR–importin-α
R8558 T9953 T9954 arg1Of association,(
R8559 T9956 T9954 arg2Of 4C,(
R8560 T9956 T9955 arg1Of 4C,Figure
R8561 T9957 T9954 arg3Of ),(
R8562 T9959 T9958 arg1Of data,These
R8563 T9959 T9961 arg1Of data,suggest
R8564 T9961 T9960 arg1Of suggest,also
R8565 T9965 T9966 arg1Of GR,and
R8566 T9966 T9963 arg1Of and,both
R8567 T9966 T9964 arg2Of and,activated
R8568 T9966 T9968 arg1Of and,can
R8569 T9966 T9970 arg1Of and,associate
R8570 T9967 T9966 arg2Of phospho-GATA-3,and
R8571 T9970 T9962 arg1Of associate,that
R8572 T9970 T9968 arg2Of associate,can
R8573 T9970 T9969 arg1Of associate,directly
R8574 T9970 T9971 arg1Of associate,with
R8575 T9970 T9977 arg1Of associate,and
R8576 T9972 T9971 arg2Of importin-α,with
R8577 T9972 T9973 arg1Of importin-α,(
R8578 T9975 T9973 arg2Of 4D,(
R8579 T9975 T9974 arg1Of 4D,Figure
R8580 T9976 T9973 arg3Of ),(
R8581 T9977 T9961 arg2Of and,suggest
R8582 T9978 T9977 arg2Of that,and
R8583 T9980 T9979 arg2Of GR,activated
R8584 T9980 T9981 arg1Of GR,attenuates
R8585 T9981 T9978 arg2Of attenuates,that
R8586 T9981 T9985 arg1Of attenuates,in
R8587 T9984 T9981 arg2Of interaction,attenuates
R8588 T9984 T9982 arg1Of interaction,the
R8589 T9984 T9983 arg1Of interaction,phospho-GATA-3/importin-α
R8590 T9988 T9985 arg2Of manner,in
R8591 T9988 T9986 arg1Of manner,a
R8592 T9988 T9987 arg1Of manner,concentration-dependent
R8593 T9988 T9989 arg1Of manner,(
R8594 T9991 T9989 arg2Of 4E,(
R8595 T9991 T9990 arg1Of 4E,Figure
R8596 T9992 T9989 arg3Of ),(
R8597 T9995 T9996 arg1Of this,suggests
R8598 T9996 T9993 arg1Of suggests,Together
R8599 T9996 T9994 arg1Of suggests,","
R8600 T9999 T9998 arg1Of GR,ligand-activated
R8601 T9999 T10000 arg1Of GR,may
R8602 T9999 T10001 arg1Of GR,compete
R8603 T9999 T10008 arg1Of GR,limit
R8604 T10001 T10000 arg2Of compete,may
R8605 T10001 T10002 arg1Of compete,with
R8606 T10001 T10004 arg1Of compete,for
R8607 T10001 T10006 arg1Of compete,and
R8608 T10003 T10002 arg2Of phospho-GATA-3,with
R8609 T10005 T10004 arg2Of importin-α,for
R8610 T10006 T9996 arg2Of and,suggests
R8611 T10006 T9997 arg1Of and,that
R8612 T10008 T10006 arg2Of limit,and
R8613 T10008 T10007 arg1Of limit,thereby
R8614 T10011 T10008 arg2Of import,limit
R8615 T10011 T10009 arg1Of import,GATA-3
R8616 T10011 T10010 arg1Of import,nuclear
R8617 T10014 T10012 arg1Of interpretations,Other
R8618 T10014 T10013 arg1Of interpretations,possible
R8619 T10014 T10015 arg1Of interpretations,of
R8620 T10014 T10018 arg1Of interpretations,could
R8621 T10014 T10019 arg1Of interpretations,include
R8622 T10017 T10015 arg2Of results,of
R8623 T10017 T10016 arg1Of results,our
R8624 T10019 T10018 arg2Of include,could
R8625 T10021 T10019 arg2Of effect,include
R8626 T10021 T10020 arg1Of effect,an
R8627 T10021 T10022 arg1Of effect,of
R8628 T10021 T10024 arg1Of effect,on
R8629 T10023 T10022 arg2Of FP,of
R8630 T10027 T10025 arg1Of export,GATA-3
R8631 T10027 T10026 arg1Of export,nuclear
R8632 T10027 T10028 arg1Of export,and/or
R8633 T10028 T10024 arg2Of and/or,on
R8634 T10029 T10028 arg2Of degradation,and/or
R8635 T10031 T10030 arg1Of B,Leptomycin
R8636 T10031 T10032 arg1Of B,","
R8637 T10031 T10033 arg1Of B,which
R8638 T10031 T10034 arg1Of B,inhibits
R8639 T10031 T10038 arg1Of B,did
R8640 T10031 T10040 arg1Of B,affect
R8641 T10036 T10034 arg2Of export,inhibits
R8642 T10036 T10035 arg1Of export,nuclear
R8643 T10040 T10037 arg1Of affect,","
R8644 T10040 T10038 arg2Of affect,did
R8645 T10040 T10039 arg1Of affect,not
R8646 T10042 T10040 arg2Of ability,affect
R8647 T10042 T10041 arg1Of ability,the
R8648 T10042 T10043 arg1Of ability,of
R8649 T10042 T10045 modOf ability,to
R8650 T10044 T10043 arg2Of FP,of
R8651 T10046 T10045 arg1Of block,to
R8652 T10049 T10046 arg2Of localization,block
R8653 T10049 T10047 arg1Of localization,GATA-3
R8654 T10049 T10048 arg1Of localization,nuclear
R8655 T10049 T10050 arg1Of localization,(
R8656 T10052 T10050 arg2Of 5A,(
R8657 T10052 T10051 arg1Of 5A,Figure
R8658 T10053 T10050 arg3Of ),(
R8659 T10056 T10057 arg1Of FP,had
R8660 T10057 T10054 arg1Of had,Additionally
R8661 T10057 T10055 arg1Of had,","
R8662 T10057 T10060 arg1Of had,on
R8663 T10057 T10065 arg1Of had,during
R8664 T10059 T10057 arg2Of effect,had
R8665 T10059 T10058 arg1Of effect,no
R8666 T10064 T10060 arg2Of expression,on
R8667 T10064 T10061 arg1Of expression,whole
R8668 T10064 T10062 arg1Of expression,cell
R8669 T10064 T10063 arg1Of expression,GATA-3
R8670 T10068 T10065 arg2Of course,during
R8671 T10068 T10066 arg1Of course,the
R8672 T10068 T10067 arg1Of course,time
R8673 T10068 T10069 arg1Of course,of
R8674 T10068 T10072 arg1Of course,(
R8675 T10071 T10069 arg2Of experiments,of
R8676 T10071 T10070 arg1Of experiments,these
R8677 T10074 T10072 arg2Of 5B,(
R8678 T10074 T10073 arg1Of 5B,Figure
R8679 T10075 T10072 arg3Of ),(
R8680 T10077 T10076 arg1Of did,Nor
R8681 T10077 T10094 arg1Of did,","
R8682 T10077 T10095 modOf did,suggesting
R8683 T10078 T10077 arg1Of addition,did
R8684 T10078 T10079 arg1Of addition,of
R8685 T10078 T10081 arg1Of addition,subsequent
R8686 T10078 T10086 arg2Of addition,affect
R8687 T10080 T10079 arg2Of FP,of
R8688 T10081 T10082 arg1Of subsequent,to
R8689 T10085 T10082 arg2Of translocation,to
R8690 T10085 T10083 arg1Of translocation,anti-CD3/CD28
R8691 T10085 T10084 arg1Of translocation,nuclear
R8692 T10089 T10086 arg1Of residency,affect
R8693 T10089 T10087 arg1Of residency,GATA-3
R8694 T10089 T10088 arg1Of residency,nuclear
R8695 T10089 T10090 arg1Of residency,(
R8696 T10092 T10090 arg2Of 5C,(
R8697 T10092 T10091 arg1Of 5C,Figure
R8698 T10093 T10090 arg3Of ),(
R8699 T10098 T10097 arg2Of GR,activated
R8700 T10098 T10099 arg1Of GR,does
R8701 T10098 T10101 arg1Of GR,enhance
R8702 T10101 T10095 arg2Of enhance,suggesting
R8703 T10101 T10096 arg1Of enhance,that
R8704 T10101 T10099 arg2Of enhance,does
R8705 T10101 T10100 arg1Of enhance,not
R8706 T10104 T10101 arg2Of export,enhance
R8707 T10104 T10102 arg1Of export,GATA-3
R8708 T10104 T10103 arg1Of export,nuclear
R8709 T10108 T10107 arg1Of effect,the
R8710 T10108 T10109 arg1Of effect,of
R8711 T10108 T10111 arg1Of effect,on
R8712 T10108 T10115 arg1Of effect,was
R8713 T10108 T10117 arg1Of effect,nonspecific
R8714 T10110 T10109 arg2Of FP,of
R8715 T10114 T10111 arg2Of import,on
R8716 T10114 T10112 arg1Of import,GATA-3
R8717 T10114 T10113 arg1Of import,nuclear
R8718 T10115 T10105 arg1Of was,Finally
R8719 T10115 T10106 arg1Of was,","
R8720 T10115 T10116 arg1Of was,not
R8721 T10115 T10118 arg1Of was,","
R8722 T10117 T10115 arg2Of nonspecific,was
R8723 T10119 T10115 arg3Of since,was
R8724 T10120 T10121 arg1Of FP,(
R8725 T10120 T10125 arg1Of FP,had
R8726 T10123 T10121 arg2Of M,(
R8727 T10123 T10122 arg1Of M,10−8
R8728 T10124 T10121 arg3Of ),(
R8729 T10125 T10119 arg2Of had,since
R8730 T10125 T10128 arg1Of had,on
R8731 T10127 T10125 arg2Of effect,had
R8732 T10127 T10126 arg1Of effect,no
R8733 T10131 T10128 arg2Of translocation,on
R8734 T10131 T10129 arg1Of translocation,p65
R8735 T10131 T10130 arg1Of translocation,nuclear
R8736 T10131 T10132 arg2Of translocation,measured
R8737 T10132 T10133 arg1Of measured,at
R8738 T10135 T10133 arg2Of min,at
R8739 T10135 T10134 arg1Of min,60
R8740 T10135 T10136 arg1Of min,(
R8741 T10138 T10136 arg2Of 5D,(
R8742 T10138 T10137 arg1Of 5D,Figure
R8743 T10139 T10136 arg3Of ),(
R9645 T11311 T11309 arg1Of Effect,The
R9646 T11311 T11310 arg1Of Effect,Inhibitory
R9647 T11311 T11312 arg1Of Effect,of
R9648 T11311 T11314 arg1Of Effect,on
R9649 T11313 T11312 arg2Of Corticosteroids,of
R9650 T11317 T11314 arg2Of Localization,on
R9651 T11317 T11315 arg1Of Localization,GATA-3
R9652 T11317 T11316 arg1Of Localization,Nuclear
R9653 T11317 T11318 arg1Of Localization,in
R9654 T11317 T11325 arg1Of Localization,In
R9655 T11317 T11326 arg1Of Localization,Vivo
R9656 T11323 T11318 arg2Of Vivo,in
R9657 T11323 T11319 arg1Of Vivo,Primary
R9658 T11323 T11320 arg1Of Vivo,T
R9659 T11323 T11321 arg1Of Vivo,Lymphocytes
R9660 T11323 T11322 arg1Of Vivo,Ex
R9661 T11323 T11324 arg1Of Vivo,and
R9662 T11327 T11328 arg1Of Treatment,with
R9663 T11327 T11332 arg1Of Treatment,demonstrated
R9664 T11329 T11328 arg2Of FP,with
R9665 T11329 T11331 arg1Of FP,vivo
R9666 T11331 T11330 arg1Of vivo,ex
R9667 T11335 T11332 arg2Of decrease,demonstrated
R9668 T11335 T11333 arg1Of decrease,a
R9669 T11335 T11334 arg1Of decrease,concentration-dependent
R9670 T11335 T11336 arg1Of decrease,in
R9671 T11339 T11336 arg2Of interaction,in
R9672 T11339 T11337 arg1Of interaction,the
R9673 T11339 T11338 arg1Of interaction,direct
R9674 T11339 T11340 arg1Of interaction,between
R9675 T11341 T11342 arg1Of phospho-GATA-3,and
R9676 T11342 T11340 arg2Of and,between
R9677 T11342 T11344 arg1Of and,in
R9678 T11342 T11356 arg1Of and,","
R9679 T11342 T11357 arg1Of and,which
R9680 T11342 T11358 arg1Of and,was
R9681 T11342 T11360 arg2Of and,inhibited
R9682 T11342 T11377 arg2Of and,attenuated
R9683 T11343 T11342 arg2Of importin-α,and
R9684 T11345 T11344 arg2Of PBMCs,in
R9685 T11345 T11346 arg1Of PBMCs,from
R9686 T11347 T11346 arg2Of patients,from
R9687 T11347 T11348 arg1Of patients,with
R9688 T11347 T11350 arg1Of patients,(
R9689 T11349 T11348 arg2Of asthma,with
R9690 T11352 T11351 arg1Of 6A,Figure
R9691 T11352 T11353 arg1Of 6A,and
R9692 T11353 T11350 arg2Of and,(
R9693 T11354 T11353 arg2Of 6B,and
R9694 T11355 T11350 arg3Of ),(
R9695 T11360 T11361 arg1Of inhibited,at
R9696 T11360 T11375 arg1Of inhibited,and
R9697 T11362 T11363 arg1Of 10−12,M
R9698 T11364 T11361 arg2Of FP,at
R9699 T11364 T11362 arg1Of FP,10−12
R9700 T11364 T11365 arg1Of FP,(
R9701 T11366 T11365 arg2Of p,(
R9702 T11366 T11367 arg1Of p,<
R9703 T11366 T11369 arg1Of p,","
R9704 T11367 T11368 arg1Of <,0.001
R9705 T11370 T11371 arg1Of ANOVA,and
R9706 T11371 T11369 arg2Of and,","
R9707 T11373 T11371 arg2Of test,and
R9708 T11373 T11372 arg1Of test,Newman-Keuls
R9709 T11374 T11365 arg3Of ),(
R9710 T11375 T11358 arg2Of and,was
R9711 T11375 T11359 arg1Of and,significantly
R9712 T11377 T11375 arg2Of attenuated,and
R9713 T11377 T11376 arg1Of attenuated,completely
R9714 T11379 T11380 arg1Of 10−8,M
R9715 T11381 T11377 arg1Of FP,attenuated
R9716 T11381 T11378 arg2Of FP,by
R9717 T11381 T11379 arg1Of FP,10−8
R9718 T11381 T11382 arg1Of FP,(
R9719 T11383 T11382 arg2Of p,(
R9720 T11383 T11384 arg1Of p,<
R9721 T11383 T11386 arg1Of p,","
R9722 T11384 T11385 arg1Of <,0.001
R9723 T11387 T11388 arg1Of ANOVA,and
R9724 T11388 T11386 arg2Of and,","
R9725 T11390 T11388 arg2Of test,and
R9726 T11390 T11389 arg1Of test,Newman-Keuls
R9727 T11391 T11382 arg3Of ),(
R9728 T11397 T11392 arg1Of studies,Our
R9729 T11397 T11393 arg1Of studies,previous
R9730 T11397 T11394 arg1Of studies,T
R9731 T11397 T11395 arg1Of studies,cell
R9732 T11397 T11396 arg1Of studies,line
R9733 T11397 T11398 arg1Of studies,indicated
R9734 T11400 T11401 arg1Of 10−12,M
R9735 T11402 T11400 arg1Of FP,10−12
R9736 T11402 T11403 arg1Of FP,suppresses
R9737 T11402 T11410 arg1Of FP,attenuated
R9738 T11403 T11409 arg1Of suppresses,and
R9739 T11404 T11405 arg1Of IL-4,and
R9740 T11406 T11405 arg2Of -5,and
R9741 T11408 T11403 arg2Of expression,suppresses
R9742 T11408 T11404 arg1Of expression,IL-4
R9743 T11408 T11406 arg1Of expression,-5
R9744 T11408 T11407 arg1Of expression,gene
R9745 T11409 T11398 arg2Of and,indicated
R9746 T11409 T11399 arg1Of and,that
R9747 T11410 T11409 arg2Of attenuated,and
R9748 T11410 T11417 arg1Of attenuated,(
R9749 T11412 T11410 arg2Of interaction,attenuated
R9750 T11412 T11411 arg1Of interaction,the
R9751 T11412 T11413 arg1Of interaction,of
R9752 T11412 T11415 arg1Of interaction,with
R9753 T11414 T11413 arg2Of GATA-3,of
R9754 T11416 T11415 arg2Of importin-α,with
R9755 T11418 T11417 arg2Of see,(
R9756 T11420 T11421 arg1Of 1D,and
R9757 T11421 T11418 arg2Of and,see
R9758 T11421 T11419 arg1Of and,Figures
R9759 T11422 T11421 arg2Of 2,and
R9760 T11423 T11417 arg3Of ),(
R9761 T11425 T11424 arg1Of concentration,This
R9762 T11425 T11426 arg1Of concentration,is
R9763 T11425 T11427 arg1Of concentration,close
R9764 T11427 T11426 arg2Of close,is
R9765 T11427 T11428 arg1Of close,to
R9766 T11431 T11428 arg2Of levels,to
R9767 T11431 T11429 arg1Of levels,peak
R9768 T11431 T11430 arg1Of levels,plasma
R9769 T11431 T11432 arg2Of levels,obtained
R9770 T11432 T11433 arg1Of obtained,from
R9771 T11435 T11433 arg2Of patients,from
R9772 T11435 T11434 arg1Of patients,asthmatic
R9773 T11435 T11436 arg2Of patients,treated
R9774 T11436 T11437 arg1Of treated,with
R9775 T11436 T11444 arg1Of treated,[
R9776 T11439 T11437 arg2Of FP,with
R9777 T11439 T11438 arg2Of FP,inhaled
R9778 T11439 T11440 arg1Of FP,(
R9779 T11442 T11440 arg2Of µg,(
R9780 T11442 T11441 arg1Of µg,500
R9781 T11443 T11440 arg3Of ),(
R9782 T11445 T11444 arg2Of 27,[
R9783 T11446 T11444 arg3Of ],[
R9784 T11448 T11447 arg2Of FP,Inhaled
R9785 T11448 T11449 arg1Of FP,(
R9786 T11451 T11449 arg2Of µg,(
R9787 T11451 T11450 arg1Of µg,500
R9788 T11452 T11449 arg3Of ),(
R9789 T11453 T11448 arg1Of treatment,FP
R9790 T11453 T11454 arg1Of treatment,of
R9791 T11453 T11460 arg1Of treatment,reduced
R9792 T11458 T11454 arg2Of patients,of
R9793 T11458 T11455 arg1Of patients,seven
R9794 T11458 T11456 arg1Of patients,steroid-naive
R9795 T11458 T11457 arg1Of patients,asthma
R9796 T11460 T11459 arg1Of reduced,significantly
R9797 T11460 T11464 arg1Of reduced,vivo
R9798 T11460 T11465 arg1Of reduced,in
R9799 T11462 T11460 arg2Of interaction,reduced
R9800 T11462 T11461 arg1Of interaction,GATA-3–importin-α
R9801 T11464 T11463 arg1Of vivo,in
R9802 T11468 T11465 arg2Of manner,in
R9803 T11468 T11466 arg1Of manner,a
R9804 T11468 T11467 arg1Of manner,time-dependent
R9805 T11469 T11470 arg1Of This,produced
R9806 T11473 T11472 arg1Of 90,>
R9807 T11473 T11474 arg1Of 90,%
R9808 T11475 T11470 arg2Of decrease,produced
R9809 T11475 T11471 arg1Of decrease,a
R9810 T11475 T11473 arg1Of decrease,90
R9811 T11475 T11476 arg1Of decrease,in
R9812 T11475 T11479 arg1Of decrease,at
R9813 T11475 T11482 arg1Of decrease,(
R9814 T11478 T11476 arg2Of association,in
R9815 T11478 T11477 arg1Of association,GATA-3–importin-α
R9816 T11481 T11479 arg2Of h,at
R9817 T11481 T11480 arg1Of h,2
R9818 T11483 T11484 arg1Of median,[
R9819 T11483 T11489 arg1Of median,","
R9820 T11485 T11486 arg1Of 95,%
R9821 T11487 T11484 arg2Of CI,[
R9822 T11487 T11485 arg1Of CI,95
R9823 T11488 T11484 arg3Of ],[
R9824 T11489 T11482 arg2Of ",",(
R9825 T11489 T11494 arg1Of ",",versus
R9826 T11490 T11489 arg2Of "13,494",","
R9827 T11490 T11491 arg1Of "13,494",[
R9828 T11492 T11491 arg2Of "6,828–17,829",[
R9829 T11493 T11491 arg3Of ],[
R9830 T11495 T11496 arg1Of 879,[
R9831 T11495 T11499 arg1Of 879,;
R9832 T11495 T11504 arg2Of 879,'s
R9833 T11497 T11496 arg2Of "597–1,165",[
R9834 T11498 T11496 arg3Of ],[
R9835 T11500 T11499 arg2Of p,;
R9836 T11500 T11503 arg1Of p,Friedman
R9837 T11503 T11501 arg1Of Friedman,<
R9838 T11503 T11502 arg1Of Friedman,0.05
R9839 T11505 T11494 arg2Of analysis,versus
R9840 T11505 T11504 arg1Of analysis,'s
R9841 T11506 T11482 arg3Of ),(
R9842 T11509 T11510 arg1Of this,did
R9843 T11509 T11512 arg1Of this,reach
R9844 T11509 T11514 arg1Of this,using
R9845 T11512 T11507 arg1Of reach,However
R9846 T11512 T11508 arg1Of reach,","
R9847 T11512 T11510 arg2Of reach,did
R9848 T11512 T11511 arg1Of reach,not
R9849 T11512 T11514 modOf reach,using
R9850 T11512 T11522 arg1Of reach,probably
R9851 T11512 T11524 arg1Of reach,to
R9852 T11513 T11512 arg2Of significance,reach
R9853 T11515 T11516 arg2Of Wilcoxon,'s
R9854 T11518 T11514 arg2Of analysis,using
R9855 T11518 T11516 arg1Of analysis,'s
R9856 T11518 T11517 arg1Of analysis,post-test
R9857 T11518 T11519 arg1Of analysis,(
R9858 T11520 T11519 arg2Of W = 6.00,(
R9859 T11521 T11519 arg3Of ),(
R9860 T11524 T11523 arg1Of to,due
R9861 T11526 T11524 arg2Of numbers,to
R9862 T11526 T11525 arg1Of numbers,low
R9863 T11526 T11527 arg1Of numbers,of
R9864 T11528 T11527 arg2Of participants,of
R9865 T11530 T11529 arg1Of results,Similar
R9866 T11530 T11531 arg1Of results,were
R9867 T11530 T11532 arg2Of results,observed
R9868 T11532 T11531 arg2Of observed,were
R9869 T11532 T11533 arg1Of observed,when
R9870 T11535 T11534 arg1Of association,GATA-3–importin-α
R9871 T11535 T11536 arg1Of association,was
R9872 T11535 T11537 arg2Of association,measured
R9873 T11537 T11533 arg2Of measured,when
R9874 T11537 T11536 arg2Of measured,was
R9875 T11537 T11538 arg1Of measured,(
R9876 T11540 T11539 arg1Of 6C,Figure
R9877 T11540 T11541 arg1Of 6C,and
R9878 T11541 T11538 arg2Of and,(
R9879 T11542 T11541 arg2Of 6D,and
R9880 T11543 T11538 arg3Of ),(
R9881 T11546 T11544 arg1Of dose,The
R9882 T11546 T11545 arg1Of dose,lower
R9883 T11546 T11547 arg1Of dose,of
R9884 T11546 T11553 arg1Of dose,was
R9885 T11546 T11555 arg1Of dose,effective
R9886 T11548 T11547 arg2Of FP,of
R9887 T11548 T11549 arg1Of FP,(
R9888 T11551 T11549 arg2Of µg,(
R9889 T11551 T11550 arg1Of µg,100
R9890 T11552 T11549 arg3Of ),(
R9891 T11553 T11554 arg1Of was,not
R9892 T11555 T11553 arg2Of effective,was
R9893 T11558 T11556 arg1Of interaction,The
R9894 T11558 T11557 arg1Of interaction,attenuated
R9895 T11558 T11559 arg1Of interaction,of
R9896 T11558 T11561 arg1Of interaction,did
R9897 T11558 T11563 arg1Of interaction,result
R9898 T11560 T11559 arg2Of GATA-3,of
R9899 T11563 T11561 arg2Of result,did
R9900 T11563 T11562 arg1Of result,not
R9901 T11563 T11564 arg1Of result,from
R9902 T11563 T11570 arg1Of result,","
R9903 T11563 T11571 arg1Of result,as
R9904 T11567 T11564 arg2Of recycling,from
R9905 T11567 T11565 arg1Of recycling,the
R9906 T11567 T11566 arg1Of recycling,defective
R9907 T11567 T11568 arg1Of recycling,of
R9908 T11569 T11568 arg2Of importin-α,of
R9909 T11574 T11572 arg1Of decrease,a
R9910 T11574 T11573 arg1Of decrease,significant
R9911 T11574 T11575 arg1Of decrease,in
R9912 T11574 T11584 arg1Of decrease,was
R9913 T11574 T11586 arg2Of decrease,detected
R9914 T11577 T11575 arg2Of abundance,in
R9915 T11577 T11576 arg1Of abundance,the
R9916 T11577 T11578 arg1Of abundance,of
R9917 T11577 T11580 arg1Of abundance,in
R9918 T11579 T11578 arg2Of importin-α,of
R9919 T11583 T11580 arg2Of pool,in
R9920 T11583 T11581 arg1Of pool,the
R9921 T11583 T11582 arg1Of pool,cytoplasmic
R9922 T11586 T11571 arg2Of detected,as
R9923 T11586 T11584 arg2Of detected,was
R9924 T11586 T11585 arg1Of detected,not
R9925 T11586 T11587 arg1Of detected,(
R9926 T11589 T11587 arg2Of 6E,(
R9927 T11589 T11588 arg1Of 6E,Figure
R9928 T11590 T11587 arg3Of ),(
R9929 T11591 T11593 arg1Of We,examined
R9930 T11593 T11592 arg1Of examined,further
R9931 T11596 T11595 arg2Of FP,inhaled
R9932 T11596 T11597 arg1Of FP,could
R9933 T11596 T11598 arg1Of FP,affect
R9934 T11598 T11593 arg2Of affect,examined
R9935 T11598 T11594 arg1Of affect,whether
R9936 T11598 T11597 arg2Of affect,could
R9937 T11600 T11598 arg2Of localization,affect
R9938 T11600 T11599 arg1Of localization,cellular
R9939 T11600 T11601 arg1Of localization,of
R9940 T11600 T11603 arg1Of localization,in
R9941 T11602 T11601 arg2Of GATA-3,of
R9942 T11607 T11603 arg2Of cells,in
R9943 T11607 T11604 arg1Of cells,peripheral
R9944 T11607 T11605 arg1Of cells,blood
R9945 T11607 T11606 arg1Of cells,T
R9946 T11608 T11609 arg1Of Treatment,with
R9947 T11608 T11616 arg1Of Treatment,for
R9948 T11608 T11620 arg1Of Treatment,increased
R9949 T11608 T11630 arg1Of Treatment,decreased
R9950 T11611 T11609 arg2Of FP,with
R9951 T11611 T11610 arg2Of FP,inhaled
R9952 T11611 T11612 arg1Of FP,(
R9953 T11614 T11612 arg2Of µg,(
R9954 T11614 T11613 arg1Of µg,500
R9955 T11615 T11612 arg3Of ),(
R9956 T11618 T11616 arg2Of h,for
R9957 T11618 T11617 arg1Of h,2
R9958 T11620 T11628 arg1Of increased,and
R9959 T11623 T11620 arg2Of translocation,increased
R9960 T11623 T11621 arg1Of translocation,GR
R9961 T11623 T11622 arg1Of translocation,nuclear
R9962 T11623 T11624 arg1Of translocation,(
R9963 T11626 T11624 arg2Of 7A,(
R9964 T11626 T11625 arg1Of 7A,Figure
R9965 T11627 T11624 arg3Of ),(
R9966 T11628 T11619 arg1Of and,significantly
R9967 T11630 T11628 arg2Of decreased,and
R9968 T11630 T11629 arg1Of decreased,concomitantly
R9969 T11630 T11661 arg1Of decreased,compared
R9970 T11632 T11630 arg2Of number,decreased
R9971 T11632 T11631 arg1Of number,the
R9972 T11632 T11633 arg1Of number,of
R9973 T11640 T11633 arg2Of cells,of
R9974 T11640 T11634 arg1Of cells,nuclear
R9975 T11640 T11635 arg1Of cells,GATA-3
R9976 T11640 T11636 arg1Of cells,immunoreactive
R9977 T11640 T11637 arg1Of cells,peripheral
R9978 T11640 T11638 arg1Of cells,blood
R9979 T11640 T11639 arg1Of cells,T
R9980 T11640 T11641 arg1Of cells,(
R9981 T11645 T11641 arg2Of %,(
R9982 T11645 T11642 arg1Of %,37
R9983 T11645 T11643 arg1Of %,%
R9984 T11645 T11644 arg1Of %,±4.2
R9985 T11645 T11646 arg1Of %,versus
R9986 T11645 T11651 arg1Of %,","
R9987 T11650 T11646 arg2Of %,versus
R9988 T11650 T11647 arg1Of %,58.2
R9989 T11650 T11648 arg1Of %,%
R9990 T11650 T11649 arg1Of %,±4.95
R9991 T11652 T11651 arg2Of p = 0.016,","
R9992 T11652 T11653 arg1Of p = 0.016,","
R9993 T11652 T11655 arg1Of p = 0.016,","
R9994 T11654 T11653 arg2Of W = 28.0,","
R9995 T11656 T11657 arg2Of Wilcoxon,'s
R9996 T11659 T11655 arg2Of test,","
R9997 T11659 T11657 arg1Of test,'s
R9998 T11659 T11658 arg1Of test,rank
R9999 T11660 T11641 arg3Of ),(
R10000 T11662 T11661 arg2Of with,compared
R10001 T11663 T11662 arg2Of placebo,with
R10002 T11663 T11664 arg1Of placebo,as
R10003 T11665 T11664 arg2Of measured,as
R10004 T11665 T11666 arg1Of measured,by
R10005 T11667 T11666 arg2Of immunocytochemistry,by
R10006 T11667 T11668 arg1Of immunocytochemistry,(
R10007 T11670 T11669 arg1Of 7A,Figure
R10008 T11670 T11671 arg1Of 7A,and
R10009 T11671 T11668 arg2Of and,(
R10010 T11672 T11671 arg2Of 7B,and
R10011 T11673 T11668 arg3Of ),(
R10012 T11674 T11675 arg1Of This,was
R10013 T11674 T11676 arg2Of This,confirmed
R10014 T11676 T11675 arg2Of confirmed,was
R10015 T11679 T11676 arg1Of blotting,confirmed
R10016 T11679 T11677 arg2Of blotting,by
R10017 T11679 T11678 arg1Of blotting,Western
R10018 T11679 T11680 arg1Of blotting,","
R10019 T11679 T11681 arg1Of blotting,which
R10020 T11679 T11683 arg1Of blotting,indicated
R10021 T11683 T11682 arg1Of indicated,also
R10022 T11686 T11685 arg1Of effect,this
R10023 T11686 T11687 arg1Of effect,was
R10024 T11687 T11683 arg2Of was,indicated
R10025 T11687 T11684 arg1Of was,that
R10026 T11689 T11690 arg1Of time-,and
R10027 T11690 T11688 arg1Of and,both
R10028 T11691 T11690 arg2Of dose-dependent,and
R10029 T11694 T11693 arg1Of 7C,Figure
R10030 T11694 T11695 arg1Of 7C,and
R10031 T11695 T11687 arg2Of and,was
R10032 T11695 T11689 arg1Of and,time-
R10033 T11695 T11691 arg1Of and,dose-dependent
R10034 T11695 T11692 arg2Of and,(
R10035 T11696 T11695 arg2Of 7D,and
R10036 T11697 T11692 arg3Of ),(
R10037 T11701 T11700 arg2Of FP,inhaled
R10038 T11701 T11702 arg1Of FP,(
R10039 T11701 T11706 arg1Of FP,induced
R10040 T11704 T11702 arg2Of µg,(
R10041 T11704 T11703 arg1Of µg,500
R10042 T11705 T11702 arg3Of ),(
R10043 T11706 T11748 arg1Of induced,and
R10044 T11708 T11706 arg2Of loss,induced
R10045 T11708 T11707 arg1Of loss,significant
R10046 T11708 T11709 arg1Of loss,in
R10047 T11708 T11712 arg1Of loss,at
R10048 T11708 T11715 arg1Of loss,(
R10049 T11708 T11744 arg1Of loss,(
R10050 T11711 T11709 arg2Of GATA-3,in
R10051 T11711 T11710 arg1Of GATA-3,nuclear
R10052 T11714 T11712 arg2Of h,at
R10053 T11714 T11713 arg1Of h,2
R10054 T11716 T11715 arg2Of median,(
R10055 T11716 T11717 arg1Of median,[
R10056 T11716 T11722 arg1Of median,","
R10057 T11716 T11732 arg1Of median,","
R10058 T11718 T11719 arg1Of 95,%
R10059 T11720 T11717 arg2Of CI,[
R10060 T11720 T11718 arg1Of CI,95
R10061 T11721 T11717 arg3Of ],[
R10062 T11723 T11722 arg2Of 0.40,","
R10063 T11723 T11724 arg1Of 0.40,[
R10064 T11723 T11727 arg1Of 0.40,versus
R10065 T11725 T11724 arg2Of 0.27–0.53,[
R10066 T11726 T11724 arg3Of ],[
R10067 T11728 T11727 arg2Of 0.14,versus
R10068 T11728 T11729 arg1Of 0.14,[
R10069 T11730 T11729 arg2Of 0.11–0.19,[
R10070 T11731 T11729 arg3Of ],[
R10071 T11733 T11732 arg2Of p,","
R10072 T11733 T11734 arg1Of p,<
R10073 T11733 T11735 arg1Of p,0.05
R10074 T11733 T11736 arg1Of p,","
R10075 T11733 T11738 arg1Of p,","
R10076 T11737 T11736 arg2Of W = 21.00,","
R10077 T11739 T11740 arg2Of Wilcoxon,'s
R10078 T11742 T11738 arg2Of test,","
R10079 T11742 T11740 arg1Of test,'s
R10080 T11742 T11741 arg1Of test,rank
R10081 T11743 T11715 arg3Of ),(
R10082 T11746 T11744 arg2Of 7C,(
R10083 T11746 T11745 arg1Of 7C,Figure
R10084 T11747 T11744 arg3Of ),(
R10085 T11748 T11698 arg1Of and,Thus
R10086 T11748 T11699 arg1Of and,","
R10087 T11751 T11749 arg1Of levels,cytoplasmic
R10088 T11751 T11750 arg1Of levels,GATA-3
R10089 T11751 T11752 arg1Of levels,were
R10090 T11751 T11753 arg2Of levels,enhanced
R10091 T11753 T11748 arg2Of enhanced,and
R10092 T11753 T11752 arg2Of enhanced,were
R10093 T11753 T11757 arg1Of enhanced,in
R10094 T11756 T11753 arg1Of FP,enhanced
R10095 T11756 T11754 arg2Of FP,by
R10096 T11756 T11755 arg2Of FP,inhaled
R10097 T11760 T11757 arg2Of manner,in
R10098 T11760 T11758 arg1Of manner,a
R10099 T11760 T11759 arg1Of manner,dose-dependent
R10100 T11760 T11761 arg1Of manner,(
R10101 T11760 T11790 arg1Of manner,(
R10102 T11762 T11761 arg2Of median,(
R10103 T11762 T11763 arg1Of median,[
R10104 T11762 T11768 arg1Of median,","
R10105 T11762 T11778 arg1Of median,","
R10106 T11764 T11765 arg1Of 95,%
R10107 T11766 T11763 arg2Of CI,[
R10108 T11766 T11764 arg1Of CI,95
R10109 T11767 T11763 arg3Of ],[
R10110 T11769 T11768 arg2Of 0.0032,","
R10111 T11769 T11770 arg1Of 0.0032,[
R10112 T11769 T11773 arg1Of 0.0032,versus
R10113 T11771 T11770 arg2Of 0.0026–0.0039,[
R10114 T11772 T11770 arg3Of ],[
R10115 T11774 T11773 arg2Of 0.658,versus
R10116 T11774 T11775 arg1Of 0.658,[
R10117 T11776 T11775 arg2Of 0.592–0.720,[
R10118 T11777 T11775 arg3Of ],[
R10119 T11779 T11778 arg2Of p,","
R10120 T11779 T11780 arg1Of p,<
R10121 T11779 T11781 arg1Of p,0.05
R10122 T11779 T11782 arg1Of p,","
R10123 T11779 T11784 arg1Of p,","
R10124 T11783 T11782 arg2Of W = −21.00,","
R10125 T11785 T11786 arg2Of Wilcoxon,'s
R10126 T11788 T11784 arg2Of test,","
R10127 T11788 T11786 arg1Of test,'s
R10128 T11788 T11787 arg1Of test,rank
R10129 T11789 T11761 arg3Of ),(
R10130 T11792 T11790 arg2Of 7D,(
R10131 T11792 T11791 arg1Of 7D,Figure
R10132 T11793 T11790 arg3Of ),(
R10133 T11795 T11794 arg2Of addition,In
R10134 T11797 T11798 arg1Of FP,(
R10135 T11797 T11802 arg1Of FP,inhibited
R10136 T11800 T11798 arg2Of µg,(
R10137 T11800 T11799 arg1Of µg,500
R10138 T11801 T11798 arg3Of ),(
R10139 T11802 T11794 arg1Of inhibited,In
R10140 T11802 T11796 arg1Of inhibited,","
R10141 T11802 T11806 arg1Of inhibited,in
R10142 T11802 T11811 arg1Of inhibited,vivo
R10143 T11802 T11812 arg1Of inhibited,at
R10144 T11802 T11815 arg1Of inhibited,in
R10145 T11805 T11802 arg2Of phosphorylation,inhibited
R10146 T11805 T11803 arg1Of phosphorylation,p38
R10147 T11805 T11804 arg1Of phosphorylation,MAPK
R10148 T11809 T11806 arg2Of cells,in
R10149 T11809 T11807 arg1Of cells,primary
R10150 T11809 T11808 arg1Of cells,T
R10151 T11811 T11810 arg1Of vivo,in
R10152 T11814 T11812 arg2Of h,at
R10153 T11814 T11813 arg1Of h,2
R10154 T11816 T11815 arg2Of samples,in
R10155 T11816 T11817 arg1Of samples,from
R10156 T11819 T11817 arg2Of patients,from
R10157 T11819 T11818 arg1Of patients,two
R10158 T11819 T11820 arg1Of patients,(
R10159 T11822 T11820 arg2Of 7E,(
R10160 T11822 T11821 arg1Of 7E,Figure
R10161 T11823 T11820 arg3Of ),(
R10162 T11824 T11825 arg1Of Taken,together
R10163 T11828 T11827 arg1Of data,our
R10164 T11828 T11829 arg1Of data,suggest
R10165 T11829 T11824 modOf suggest,Taken
R10166 T11829 T11826 arg1Of suggest,","
R10167 T11832 T11831 arg2Of FP,inhaled
R10168 T11832 T11833 arg1Of FP,reduces
R10169 T11833 T11829 arg2Of reduces,suggest
R10170 T11833 T11830 arg1Of reduces,that
R10171 T11833 T11839 arg1Of reduces,vivo
R10172 T11833 T11840 arg1Of reduces,by
R10173 T11835 T11833 arg2Of localization,reduces
R10174 T11835 T11834 arg1Of localization,nuclear
R10175 T11835 T11836 arg1Of localization,of
R10176 T11837 T11836 arg2Of GATA-3,of
R10177 T11839 T11838 arg1Of vivo,in
R10178 T11842 T11840 arg2Of inhibiting,by
R10179 T11842 T11841 arg1Of inhibiting,acutely
R10180 T11844 T11842 arg2Of association,inhibiting
R10181 T11844 T11843 arg1Of association,phospho-GATA-3–importin
R10182 T11846 T11845 arg1Of effect,This
R10183 T11846 T11847 arg1Of effect,may
R10184 T11846 T11848 arg1Of effect,be
R10185 T11846 T11849 arg1Of effect,direct
R10186 T11846 T11860 arg1Of effect,secondary
R10187 T11848 T11847 arg2Of be,may
R10188 T11849 T11850 arg1Of direct,","
R10189 T11849 T11851 arg1Of direct,through
R10190 T11849 T11859 arg1Of direct,or
R10191 T11852 T11851 arg2Of competition,through
R10192 T11852 T11853 arg1Of competition,for
R10193 T11854 T11855 arg1Of importin-α,or
R10194 T11855 T11853 arg2Of or,for
R10195 T11857 T11855 arg2Of molecules,or
R10196 T11857 T11856 arg2Of molecules,associated
R10197 T11859 T11848 arg2Of or,be
R10198 T11859 T11858 arg1Of or,","
R10199 T11860 T11859 arg2Of secondary,or
R10200 T11860 T11861 arg1Of secondary,to
R10201 T11863 T11861 arg2Of effect,to
R10202 T11863 T11862 arg1Of effect,an
R10203 T11863 T11864 arg1Of effect,on
R10204 T11863 T11869 arg1Of effect,via
R10205 T11868 T11864 arg2Of phosphorylation,on
R10206 T11868 T11865 arg1Of phosphorylation,p38
R10207 T11868 T11866 arg1Of phosphorylation,MAPK-mediated
R10208 T11868 T11867 arg1Of phosphorylation,GATA-3
R10209 T11871 T11869 arg2Of induction,via
R10210 T11871 T11870 arg1Of induction,rapid
R10211 T11871 T11872 arg1Of induction,of
R10212 T11873 T11872 arg2Of MKP-1,of
R10213 T11875 T11874 arg1Of combination,The
R10214 T11875 T11876 arg1Of combination,of
R10215 T11875 T11881 arg1Of combination,can
R10216 T11875 T11882 arg1Of combination,result
R10217 T11880 T11876 arg2Of effects,of
R10218 T11880 T11877 arg1Of effects,these
R10219 T11880 T11878 arg1Of effects,two
R10220 T11880 T11879 arg1Of effects,interacting
R10221 T11882 T11881 arg2Of result,can
R10222 T11882 T11883 arg1Of result,in
R10223 T11885 T11884 arg1Of suppression,complete
R10224 T11885 T11886 arg1Of suppression,of
R10225 T11885 T11890 arg1Of suppression,and
R10226 T11889 T11886 arg2Of import,of
R10227 T11889 T11887 arg1Of import,GATA-3
R10228 T11889 T11888 arg1Of import,nuclear
R10229 T11890 T11883 arg2Of and,in
R10230 T11895 T11890 arg2Of expression,and
R10231 T11895 T11891 arg1Of expression,thus
R10232 T11895 T11892 arg1Of expression,Th2
R10233 T11895 T11893 arg1Of expression,cytokine
R10234 T11895 T11894 arg1Of expression,gene
R11419 T13352 T13353 arg1Of we,have
R11420 T13352 T13354 arg1Of we,demonstrated
R11421 T13354 T13351 arg1Of demonstrated,Here
R11422 T13354 T13353 arg2Of demonstrated,have
R11423 T13354 T13355 arg1Of demonstrated,","
R11424 T13354 T13356 arg1Of demonstrated,to
R11425 T13354 T13363 arg1Of demonstrated,","
R11426 T13358 T13356 arg2Of knowledge,to
R11427 T13358 T13357 arg1Of knowledge,our
R11428 T13358 T13359 arg1Of knowledge,for
R11429 T13362 T13359 arg2Of time,for
R11430 T13362 T13360 arg1Of time,the
R11431 T13362 T13361 arg1Of time,first
R11432 T13365 T13366 arg1Of corticosteroids,may
R11433 T13365 T13367 arg1Of corticosteroids,inhibit
R11434 T13367 T13354 arg2Of inhibit,demonstrated
R11435 T13367 T13364 arg1Of inhibit,that
R11436 T13367 T13366 arg2Of inhibit,may
R11437 T13369 T13368 arg1Of function,GATA-3
R11438 T13369 T13370 arg1Of function,and
R11439 T13370 T13367 arg2Of and,inhibit
R11440 T13373 T13370 arg2Of transcription,and
R11441 T13373 T13371 arg1Of transcription,therefore
R11442 T13373 T13372 arg1Of transcription,the
R11443 T13373 T13374 arg1Of transcription,of
R11444 T13373 T13377 arg1Of transcription,via
R11445 T13376 T13374 arg2Of genes,of
R11446 T13376 T13375 arg1Of genes,Th2
R11447 T13379 T13380 arg1Of distinct,but
R11448 T13381 T13380 arg2Of interacting,but
R11449 T13383 T13377 arg2Of mechanisms,via
R11450 T13383 T13378 arg1Of mechanisms,two
R11451 T13383 T13379 arg1Of mechanisms,distinct
R11452 T13383 T13381 arg1Of mechanisms,interacting
R11453 T13383 T13382 arg1Of mechanisms,molecular
R11454 T13387 T13386 arg1Of GR,corticosteroid-activated
R11455 T13387 T13388 arg1Of GR,appears
R11456 T13387 T13390 arg1Of GR,compete
R11457 T13388 T13384 arg1Of appears,Firstly
R11458 T13388 T13385 arg1Of appears,","
R11459 T13390 T13388 arg2Of compete,appears
R11460 T13390 T13389 arg1Of compete,to
R11461 T13390 T13391 arg1Of compete,with
R11462 T13390 T13397 arg1Of compete,via
R11463 T13393 T13391 arg2Of GATA-3,with
R11464 T13393 T13392 arg2Of GATA-3,activated
R11465 T13393 T13394 arg1Of GATA-3,for
R11466 T13396 T13394 arg2Of import,for
R11467 T13396 T13395 arg1Of import,nuclear
R11468 T13398 T13397 arg2Of importin-α,via
R11469 T13398 T13399 arg1Of importin-α,","
R11470 T13398 T13400 arg1Of importin-α,which
R11471 T13398 T13401 arg1Of importin-α,is
R11472 T13398 T13402 arg2Of importin-α,required
R11473 T13402 T13401 arg2Of required,is
R11474 T13402 T13403 arg1Of required,for
R11475 T13406 T13403 arg2Of transport,for
R11476 T13406 T13404 arg1Of transport,the
R11477 T13406 T13405 arg1Of transport,nuclear
R11478 T13406 T13407 arg1Of transport,of
R11479 T13409 T13410 arg1Of GATA-3,and
R11480 T13410 T13407 arg2Of and,of
R11481 T13410 T13408 arg1Of and,both
R11482 T13411 T13410 arg2Of GR,and
R11483 T13414 T13415 arg1Of corticosteroids,at
R11484 T13414 T13418 arg1Of corticosteroids,increase
R11485 T13414 T13433 arg1Of corticosteroids,prevent
R11486 T13417 T13415 arg2Of concentrations,at
R11487 T13417 T13416 arg1Of concentrations,higher
R11488 T13418 T13431 arg1Of increase,and
R11489 T13420 T13418 arg2Of expression,increase
R11490 T13420 T13419 arg1Of expression,the
R11491 T13420 T13421 arg1Of expression,of
R11492 T13422 T13421 arg2Of MKP-1,of
R11493 T13422 T13423 arg1Of MKP-1,","
R11494 T13426 T13423 arg2Of inhibitor,","
R11495 T13426 T13424 arg1Of inhibitor,a
R11496 T13426 T13425 arg1Of inhibitor,potent
R11497 T13426 T13427 arg1Of inhibitor,of
R11498 T13430 T13427 arg2Of activity,of
R11499 T13430 T13428 arg1Of activity,p38
R11500 T13430 T13429 arg1Of activity,MAPK
R11501 T13431 T13412 arg1Of and,Secondly
R11502 T13431 T13413 arg1Of and,","
R11503 T13433 T13431 arg2Of prevent,and
R11504 T13433 T13432 arg1Of prevent,thereby
R11505 T13437 T13433 arg2Of activation,prevent
R11506 T13437 T13434 arg1Of activation,T
R11507 T13437 T13435 arg1Of activation,cell
R11508 T13437 T13436 arg1Of activation,receptor/co-receptor
R11509 T13437 T13438 arg1Of activation,of
R11510 T13437 T13441 modOf activation,to
R11511 T13440 T13438 arg2Of MAPK,of
R11512 T13440 T13439 arg1Of MAPK,p38
R11513 T13442 T13441 arg1Of prevent,to
R11514 T13444 T13442 arg2Of phosphorylation,prevent
R11515 T13444 T13443 arg1Of phosphorylation,the
R11516 T13444 T13445 arg1Of phosphorylation,of
R11517 T13444 T13447 arg1Of phosphorylation,that
R11518 T13444 T13448 arg1Of phosphorylation,is
R11519 T13444 T13449 arg1Of phosphorylation,necessary
R11520 T13446 T13445 arg2Of GATA-3,of
R11521 T13449 T13448 arg2Of necessary,is
R11522 T13449 T13450 arg1Of necessary,for
R11523 T13451 T13450 arg2Of interaction,for
R11524 T13451 T13452 arg1Of interaction,with
R11525 T13453 T13454 arg1Of importin-α,and
R11526 T13455 T13454 arg2Of subsequent,and
R11527 T13457 T13452 arg2Of import,with
R11528 T13457 T13453 arg1Of import,importin-α
R11529 T13457 T13455 arg1Of import,subsequent
R11530 T13457 T13456 arg1Of import,nuclear
R11531 T13458 T13459 arg1Of We,have
R11532 T13458 T13461 arg1Of We,shown
R11533 T13461 T13459 arg2Of shown,have
R11534 T13461 T13460 arg1Of shown,previously
R11535 T13463 T13464 arg1Of translocation,of
R11536 T13463 T13469 arg1Of translocation,to
R11537 T13463 T13472 arg1Of translocation,involves
R11538 T13465 T13464 arg2Of GATA-3,of
R11539 T13465 T13466 arg1Of GATA-3,from
R11540 T13468 T13466 arg2Of cytoplasm,from
R11541 T13468 T13467 arg1Of cytoplasm,the
R11542 T13471 T13469 arg2Of nucleus,to
R11543 T13471 T13470 arg1Of nucleus,the
R11544 T13472 T13461 arg2Of involves,shown
R11545 T13472 T13462 arg1Of involves,that
R11546 T13477 T13472 arg2Of importin-α,involves
R11547 T13477 T13473 arg1Of importin-α,the
R11548 T13477 T13474 arg1Of importin-α,nuclear
R11549 T13477 T13475 arg1Of importin-α,transporter
R11550 T13477 T13476 arg1Of importin-α,protein
R11551 T13477 T13478 arg1Of importin-α,","
R11552 T13477 T13479 arg1Of importin-α,which
R11553 T13477 T13480 arg1Of importin-α,interacts
R11554 T13480 T13481 arg1Of interacts,with
R11555 T13480 T13484 arg1Of interacts,[
R11556 T13483 T13481 arg2Of GATA-3,with
R11557 T13483 T13482 arg2Of GATA-3,phosphorylated
R11558 T13485 T13484 arg2Of 12,[
R11559 T13486 T13484 arg3Of ],[
R11560 T13487 T13488 arg1Of We,have
R11561 T13487 T13491 arg1Of We,reported
R11562 T13491 T13488 arg2Of reported,have
R11563 T13491 T13489 arg1Of reported,also
R11564 T13491 T13490 arg1Of reported,previously
R11565 T13494 T13493 arg1Of knockdown,GATA-3
R11566 T13494 T13495 arg1Of knockdown,using
R11567 T13494 T13497 arg1Of knockdown,results
R11568 T13496 T13495 arg2Of siRNA,using
R11569 T13497 T13491 arg2Of results,reported
R11570 T13497 T13492 arg1Of results,that
R11571 T13497 T13498 arg1Of results,in
R11572 T13497 T13505 arg1Of results,","
R11573 T13497 T13507 modOf results,implicating
R11574 T13499 T13498 arg2Of suppression,in
R11575 T13499 T13500 arg1Of suppression,of
R11576 T13504 T13500 arg2Of induction,of
R11577 T13504 T13501 arg1Of induction,anti-CD3/CD28–stimulated
R11578 T13504 T13502 arg1Of induction,IL-4/IL-5
R11579 T13504 T13503 arg1Of induction,mRNA
R11580 T13507 T13506 arg1Of implicating,thus
R11581 T13507 T13519 arg1Of implicating,[
R11582 T13510 T13507 arg2Of role,implicating
R11583 T13510 T13508 arg1Of role,an
R11584 T13510 T13509 arg1Of role,essential
R11585 T13510 T13511 arg1Of role,for
R11586 T13510 T13513 arg1Of role,in
R11587 T13512 T13511 arg2Of GATA-3,for
R11588 T13515 T13513 arg2Of transcription,in
R11589 T13515 T13514 arg1Of transcription,the
R11590 T13515 T13516 arg1Of transcription,of
R11591 T13518 T13516 arg2Of genes,of
R11592 T13518 T13517 arg1Of genes,these
R11593 T13520 T13519 arg2Of 12,[
R11594 T13521 T13519 arg3Of ],[
R11595 T13522 T13524 arg1Of We,confirm
R11596 T13524 T13523 arg1Of confirm,now
R11597 T13524 T13525 arg1Of confirm,","
R11598 T13524 T13526 arg1Of confirm,in
R11599 T13524 T13530 arg1Of confirm,","
R11600 T13529 T13526 arg2Of cells,in
R11601 T13529 T13527 arg1Of cells,human
R11602 T13529 T13528 arg1Of cells,T
R11603 T13532 T13534 arg1Of GR,uses
R11604 T13534 T13524 arg2Of uses,confirm
R11605 T13534 T13531 arg1Of uses,that
R11606 T13534 T13533 arg1Of uses,also
R11607 T13534 T13540 arg1Of uses,as
R11608 T13534 T13542 arg1Of uses,[
R11609 T13539 T13534 arg2Of mechanism,uses
R11610 T13539 T13535 arg1Of mechanism,the
R11611 T13539 T13536 arg1Of mechanism,same
R11612 T13539 T13537 arg1Of mechanism,nuclear
R11613 T13539 T13538 arg1Of mechanism,import
R11614 T13541 T13540 arg2Of GATA-3,as
R11615 T13543 T13542 arg2Of 22,[
R11616 T13544 T13542 arg3Of ],[
R11617 T13545 T13547 arg1Of We,propose
R11618 T13547 T13546 arg1Of propose,therefore
R11619 T13549 T13550 arg1Of there,is
R11620 T13550 T13547 arg2Of is,propose
R11621 T13550 T13548 arg1Of is,that
R11622 T13551 T13550 arg2Of competition,is
R11623 T13551 T13552 arg1Of competition,between
R11624 T13551 T13557 arg1Of competition,for
R11625 T13554 T13555 arg1Of GR,and
R11626 T13555 T13552 arg2Of and,between
R11627 T13555 T13553 arg1Of and,ligand-activated
R11628 T13556 T13555 arg2Of phospho-GATA-3,and
R11629 T13559 T13557 arg2Of import,for
R11630 T13559 T13558 arg1Of import,nuclear
R11631 T13562 T13563 arg1Of we,have
R11632 T13562 T13564 arg1Of we,shown
R11633 T13564 T13560 arg1Of shown,Furthermore
R11634 T13564 T13561 arg1Of shown,","
R11635 T13564 T13563 arg2Of shown,have
R11636 T13566 T13567 arg1Of there,is
R11637 T13567 T13564 arg2Of is,shown
R11638 T13567 T13565 arg1Of is,that
R11639 T13567 T13577 arg1Of is,","
R11640 T13567 T13578 arg1Of is,so
R11641 T13569 T13567 arg2Of binding,is
R11642 T13569 T13568 arg1Of binding,preferential
R11643 T13569 T13570 arg1Of binding,of
R11644 T13569 T13572 arg1Of binding,to
R11645 T13569 T13575 arg1Of binding,over
R11646 T13571 T13570 arg2Of importin-α,of
R11647 T13574 T13572 arg2Of GR,to
R11648 T13574 T13573 arg2Of GR,activated
R11649 T13576 T13575 arg2Of phospho-GATA-3,over
R11650 T13578 T13579 arg1Of so,that
R11651 T13580 T13581 arg1Of corticosteroids,would
R11652 T13580 T13583 arg1Of corticosteroids,reduce
R11653 T13580 T13589 arg1Of corticosteroids,switch
R11654 T13583 T13586 arg1Of reduce,and
R11655 T13585 T13583 arg2Of entry,reduce
R11656 T13585 T13584 arg1Of entry,GATA-3
R11657 T13586 T13578 arg2Of and,so
R11658 T13586 T13581 arg2Of and,would
R11659 T13586 T13582 arg1Of and,preferentially
R11660 T13589 T13586 arg2Of switch,and
R11661 T13589 T13587 arg1Of switch,thus
R11662 T13589 T13588 arg1Of switch,rapidly
R11663 T13589 T13590 arg1Of switch,off
R11664 T13589 T13594 arg1Of switch,without
R11665 T13593 T13589 arg2Of transcription,switch
R11666 T13593 T13591 arg1Of transcription,Th2
R11667 T13593 T13592 arg1Of transcription,gene
R11668 T13596 T13594 arg2Of need,without
R11669 T13596 T13595 arg1Of need,any
R11670 T13596 T13597 arg1Of need,for
R11671 T13600 T13597 arg2Of steps,for
R11672 T13600 T13598 arg1Of steps,any
R11673 T13600 T13599 arg1Of steps,intermediate
R11674 T13603 T13604 arg1Of there,was
R11675 T13604 T13601 arg1Of was,Furthermore
R11676 T13604 T13602 arg1Of was,","
R11677 T13604 T13611 arg1Of was,","
R11678 T13604 T13612 arg1Of was,as
R11679 T13606 T13604 arg2Of degree,was
R11680 T13606 T13605 arg1Of degree,some
R11681 T13606 T13607 arg1Of degree,of
R11682 T13606 T13609 arg1Of degree,for
R11683 T13608 T13607 arg2Of specificity,of
R11684 T13610 T13609 arg2Of GATA-3,for
R11685 T13614 T13613 arg1Of translocation,nuclear
R11686 T13614 T13615 arg1Of translocation,of
R11687 T13614 T13621 arg1Of translocation,was
R11688 T13614 T13623 arg2Of translocation,affected
R11689 T13618 T13615 arg2Of subunit,of
R11690 T13618 T13616 arg1Of subunit,the
R11691 T13618 T13617 arg1Of subunit,p65
R11692 T13618 T13619 arg1Of subunit,of
R11693 T13620 T13619 arg2Of NF-κB,of
R11694 T13623 T13612 arg2Of affected,as
R11695 T13623 T13621 arg2Of affected,was
R11696 T13623 T13622 arg1Of affected,not
R11697 T13626 T13623 arg1Of exposure,affected
R11698 T13626 T13624 arg2Of exposure,by
R11699 T13626 T13625 arg1Of exposure,corticosteroid
R11700 T13627 T13628 arg1Of We,tested
R11701 T13627 T13642 arg1Of We,failed
R11702 T13627 T13644 arg1Of We,show
R11703 T13628 T13641 arg1Of tested,and
R11704 T13631 T13628 arg2Of explanations,tested
R11705 T13631 T13629 arg1Of explanations,some
R11706 T13631 T13630 arg1Of explanations,alternative
R11707 T13631 T13632 arg1Of explanations,for
R11708 T13634 T13632 arg2Of effect,for
R11709 T13634 T13633 arg1Of effect,this
R11710 T13634 T13635 arg1Of effect,of
R11711 T13634 T13637 arg1Of effect,on
R11712 T13636 T13635 arg2Of FP,of
R11713 T13640 T13637 arg2Of exclusion,on
R11714 T13640 T13638 arg1Of exclusion,GATA-3
R11715 T13640 T13639 arg1Of exclusion,nuclear
R11716 T13642 T13641 arg2Of failed,and
R11717 T13644 T13642 arg2Of show,failed
R11718 T13644 T13643 arg1Of show,to
R11719 T13646 T13648 arg1Of FP,enhances
R11720 T13646 T13654 arg1Of FP,induces
R11721 T13648 T13647 arg1Of enhances,either
R11722 T13648 T13652 arg1Of enhances,directly
R11723 T13648 T13653 arg1Of enhances,or
R11724 T13651 T13648 arg2Of export,enhances
R11725 T13651 T13649 arg1Of export,GATA-3
R11726 T13651 T13650 arg1Of export,nuclear
R11727 T13653 T13644 arg2Of or,show
R11728 T13653 T13645 arg1Of or,that
R11729 T13654 T13653 arg2Of induces,or
R11730 T13656 T13654 arg2Of degradation,induces
R11731 T13656 T13655 arg1Of degradation,GATA-3
R11732 T13658 T13657 arg1Of evidence,The
R11733 T13658 T13659 arg1Of evidence,from
R11734 T13658 T13665 arg1Of evidence,does
R11735 T13658 T13669 arg1Of evidence,suggest
R11736 T13662 T13661 arg1Of vitro,in
R11737 T13664 T13659 arg2Of assays,from
R11738 T13664 T13660 arg1Of assays,the
R11739 T13664 T13662 arg1Of assays,vitro
R11740 T13664 T13663 arg1Of assays,competition
R11741 T13669 T13665 arg2Of suggest,does
R11742 T13669 T13666 arg1Of suggest,","
R11743 T13669 T13667 arg1Of suggest,however
R11744 T13669 T13668 arg1Of suggest,","
R11745 T13673 T13671 arg2Of GR,purified
R11746 T13673 T13672 arg2Of GR,activated
R11747 T13673 T13674 arg1Of GR,can
R11748 T13673 T13676 arg1Of GR,attenuate
R11749 T13676 T13670 arg1Of attenuate,that
R11750 T13676 T13674 arg2Of attenuate,can
R11751 T13676 T13675 arg1Of attenuate,clearly
R11752 T13676 T13680 arg1Of attenuate,and
R11753 T13679 T13676 arg2Of association,attenuate
R11754 T13679 T13677 arg2Of association,purified
R11755 T13679 T13678 arg1Of association,phospho-GATA-3–importin-α
R11756 T13680 T13669 arg2Of and,suggest
R11757 T13681 T13680 arg2Of that,and
R11758 T13683 T13682 arg1Of converse,the
R11759 T13683 T13684 arg1Of converse,does
R11760 T13683 T13686 arg1Of converse,occur
R11761 T13686 T13681 arg2Of occur,that
R11762 T13686 T13684 arg2Of occur,does
R11763 T13686 T13685 arg1Of occur,not
R11764 T13689 T13690 arg1Of we,have
R11765 T13689 T13691 arg1Of we,shown
R11766 T13691 T13687 arg1Of shown,Furthermore
R11767 T13691 T13688 arg1Of shown,","
R11768 T13691 T13690 arg2Of shown,have
R11769 T13694 T13693 arg1Of phospho-GATA-3,only
R11770 T13694 T13695 arg1Of phospho-GATA-3,can
R11771 T13694 T13696 arg1Of phospho-GATA-3,associate
R11772 T13696 T13691 arg2Of associate,shown
R11773 T13696 T13692 arg1Of associate,that
R11774 T13696 T13695 arg2Of associate,can
R11775 T13696 T13697 arg1Of associate,with
R11776 T13698 T13697 arg2Of importin-α,with
R11777 T13700 T13699 arg1Of mechanism,This
R11778 T13700 T13701 arg1Of mechanism,is
R11779 T13700 T13702 arg1Of mechanism,sensitive
R11780 T13700 T13710 arg1Of mechanism,would
R11781 T13700 T13711 arg1Of mechanism,be
R11782 T13700 T13712 arg1Of mechanism,rapid
R11783 T13701 T13709 arg1Of is,and
R11784 T13702 T13701 arg2Of sensitive,is
R11785 T13702 T13703 arg1Of sensitive,to
R11786 T13705 T13704 arg1Of low,very
R11787 T13706 T13703 arg2Of concentrations,to
R11788 T13706 T13705 arg1Of concentrations,low
R11789 T13706 T13707 arg1Of concentrations,of
R11790 T13708 T13707 arg2Of corticosteroid,of
R11791 T13711 T13709 arg2Of be,and
R11792 T13711 T13710 arg2Of be,would
R11793 T13711 T13713 arg1Of be,in
R11794 T13711 T13715 arg1Of be,as
R11795 T13712 T13711 arg2Of rapid,be
R11796 T13714 T13713 arg2Of onset,in
R11797 T13717 T13716 arg1Of changes,no
R11798 T13717 T13718 arg1Of changes,in
R11799 T13717 T13721 arg1Of changes,are
R11800 T13717 T13722 arg2Of changes,required
R11801 T13720 T13718 arg2Of synthesis,in
R11802 T13720 T13719 arg1Of synthesis,protein
R11803 T13722 T13715 arg2Of required,as
R11804 T13722 T13721 arg2Of required,are
R11805 T13725 T13723 arg1Of mechanism,This
R11806 T13725 T13724 arg1Of mechanism,acute
R11807 T13725 T13726 arg1Of mechanism,may
R11808 T13725 T13728 arg1Of mechanism,contribute
R11809 T13725 T13737 arg1Of mechanism,may
R11810 T13725 T13738 arg1Of mechanism,play
R11811 T13728 T13726 arg2Of contribute,may
R11812 T13728 T13727 arg1Of contribute,also
R11813 T13728 T13729 arg1Of contribute,to
R11814 T13728 T13736 arg1Of contribute,and
R11815 T13731 T13729 arg2Of reduction,to
R11816 T13731 T13730 arg1Of reduction,the
R11817 T13731 T13732 arg1Of reduction,in
R11818 T13735 T13732 arg2Of import,in
R11819 T13735 T13733 arg1Of import,GATA-3
R11820 T13735 T13734 arg1Of import,nuclear
R11821 T13738 T13736 arg2Of play,and
R11822 T13738 T13737 arg2Of play,may
R11823 T13738 T13742 arg1Of play,at
R11824 T13738 T13747 arg1Of play,at
R11825 T13741 T13738 arg2Of role,play
R11826 T13741 T13739 arg1Of role,a
R11827 T13741 T13740 arg1Of role,major
R11828 T13742 T13746 arg1Of at,and/or
R11829 T13745 T13742 arg2Of concentrations,at
R11830 T13745 T13743 arg1Of concentrations,low
R11831 T13745 T13744 arg1Of concentrations,corticosteroid
R11832 T13747 T13746 arg2Of at,and/or
R11833 T13750 T13747 arg2Of points,at
R11834 T13750 T13748 arg1Of points,early
R11835 T13750 T13749 arg1Of points,time
R11836 T13750 T13751 arg1Of points,prior
R11837 T13751 T13752 arg1Of prior,to
R11838 T13754 T13752 arg2Of induction,to
R11839 T13754 T13753 arg1Of induction,MKP-1
R11840 T13755 T13756 arg1Of Corticosteroids,can
R11841 T13755 T13757 arg1Of Corticosteroids,modulate
R11842 T13757 T13756 arg2Of modulate,can
R11843 T13757 T13761 arg1Of modulate,through
R11844 T13757 T13777 arg1Of modulate,","
R11845 T13757 T13778 arg1Of modulate,[
R11846 T13760 T13757 arg2Of activity,modulate
R11847 T13760 T13758 arg1Of activity,p38
R11848 T13760 T13759 arg1Of activity,MAPK
R11849 T13763 T13761 arg2Of induction,through
R11850 T13763 T13762 arg1Of induction,the
R11851 T13763 T13764 arg1Of induction,of
R11852 T13763 T13766 arg1Of induction,","
R11853 T13765 T13764 arg2Of MKP-1,of
R11854 T13770 T13766 arg2Of inhibitor,","
R11855 T13770 T13767 arg1Of inhibitor,a
R11856 T13770 T13768 arg1Of inhibitor,potent
R11857 T13770 T13769 arg1Of inhibitor,endogenous
R11858 T13770 T13771 arg1Of inhibitor,of
R11859 T13773 T13771 arg2Of function,of
R11860 T13773 T13772 arg1Of function,MAPK
R11861 T13773 T13774 arg1Of function,[
R11862 T13775 T13774 arg2Of 38,[
R11863 T13776 T13774 arg3Of ],[
R11864 T13779 T13778 arg2Of 39,[
R11865 T13780 T13778 arg3Of ],[
R11866 T13781 T13782 arg1Of We,report
R11867 T13782 T13783 arg1Of report,here
R11868 T13786 T13782 arg2Of induction,report
R11869 T13786 T13784 arg1Of induction,a
R11870 T13786 T13785 arg1Of induction,rapid
R11871 T13786 T13787 arg1Of induction,of
R11872 T13786 T13790 arg1Of induction,following
R11873 T13789 T13787 arg2Of mRNA,of
R11874 T13789 T13788 arg1Of mRNA,MKP-1
R11875 T13791 T13790 arg2Of stimulation,following
R11876 T13791 T13792 arg1Of stimulation,of
R11877 T13791 T13794 arg1Of stimulation,with
R11878 T13793 T13792 arg2Of cells,of
R11879 T13796 T13795 arg1Of high,relatively
R11880 T13797 T13794 arg2Of concentrations,with
R11881 T13797 T13796 arg1Of concentrations,high
R11882 T13797 T13798 arg1Of concentrations,of
R11883 T13799 T13798 arg2Of FP,of
R11884 T13800 T13801 arg1Of We,hypothesize
R11885 T13805 T13803 arg1Of induction,this
R11886 T13805 T13804 arg1Of induction,rapid
R11887 T13805 T13806 arg1Of induction,of
R11888 T13805 T13808 arg1Of induction,can
R11889 T13805 T13809 arg1Of induction,reduce
R11890 T13805 T13814 arg1Of induction,attenuating
R11891 T13805 T13824 arg1Of induction,preventing
R11892 T13807 T13806 arg2Of MKP-1,of
R11893 T13809 T13801 arg2Of reduce,hypothesize
R11894 T13809 T13802 arg1Of reduce,that
R11895 T13809 T13808 arg2Of reduce,can
R11896 T13809 T13813 arg1Of reduce,by
R11897 T13812 T13809 arg2Of import,reduce
R11898 T13812 T13810 arg1Of import,GATA-3
R11899 T13812 T13811 arg1Of import,nuclear
R11900 T13814 T13822 arg1Of attenuating,","
R11901 T13817 T13815 arg1Of activity,p38
R11902 T13817 T13816 arg1Of activity,MAPK
R11903 T13817 T13818 arg1Of activity,and
R11904 T13818 T13814 arg2Of and,attenuating
R11905 T13821 T13818 arg2Of phosphorylation,and
R11906 T13821 T13819 arg1Of phosphorylation,subsequent
R11907 T13821 T13820 arg1Of phosphorylation,GATA-3
R11908 T13822 T13813 arg2Of ",",by
R11909 T13824 T13822 arg2Of preventing,","
R11910 T13824 T13823 arg1Of preventing,thus
R11911 T13826 T13824 arg2Of translocation,preventing
R11912 T13826 T13825 arg1Of translocation,nuclear
R11913 T13828 T13827 arg1Of location,The
R11914 T13828 T13829 arg1Of location,of
R11915 T13828 T13838 arg1Of location,that
R11916 T13828 T13839 arg1Of location,are
R11917 T13828 T13840 arg2Of location,phosphorylated
R11918 T13828 T13844 arg1Of location,are
R11919 T13828 T13846 arg1Of location,unknown
R11920 T13832 T13829 arg2Of residue,of
R11921 T13832 T13830 arg1Of residue,the
R11922 T13832 T13831 arg1Of residue,serine
R11923 T13832 T13833 arg1Of residue,(
R11924 T13832 T13836 arg1Of residue,of
R11925 T13834 T13833 arg2Of s,(
R11926 T13835 T13833 arg3Of ),(
R11927 T13837 T13836 arg2Of GATA-3,of
R11928 T13840 T13839 arg2Of phosphorylated,are
R11929 T13843 T13840 arg1Of MAPK,phosphorylated
R11930 T13843 T13841 arg2Of MAPK,by
R11931 T13843 T13842 arg1Of MAPK,p38
R11932 T13844 T13845 arg1Of are,currently
R11933 T13844 T13848 arg1Of are,but
R11934 T13846 T13844 arg2Of unknown,are
R11935 T13848 T13847 arg1Of but,","
R11936 T13854 T13849 arg1Of Scanner,a
R11937 T13854 T13850 arg1Of Scanner,bioinformatics
R11938 T13854 T13851 arg1Of Scanner,search
R11939 T13854 T13852 arg1Of Scanner,(
R11940 T13854 T13853 arg1Of Scanner,Motif
R11941 T13854 T13855 arg1Of Scanner,","
R11942 T13854 T13860 arg1Of Scanner,indicates
R11943 T13856 T13855 arg2Of http,","
R11944 T13856 T13857 arg1Of http,:
R11945 T13858 T13859 arg1Of //scansite.mit.edu/motifscan_seq.phtml,)
R11946 T13860 T13848 arg2Of indicates,but
R11947 T13860 T13858 arg1Of indicates,//scansite.mit.edu/motifscan_seq.phtml
R11948 T13863 T13861 arg1Of three,at
R11949 T13863 T13862 arg1Of three,least
R11950 T13868 T13860 arg2Of residues,indicates
R11951 T13868 T13863 arg1Of residues,three
R11952 T13868 T13864 arg1Of residues,potential
R11953 T13868 T13865 arg1Of residues,p38
R11954 T13868 T13866 arg1Of residues,MAPK-sensitive
R11955 T13868 T13867 arg1Of residues,serine
R11956 T13870 T13869 arg2Of predicted,As
R11957 T13870 T13871 arg1Of predicted,from
R11958 T13874 T13873 arg1Of vitro,in
R11959 T13875 T13871 arg2Of data,from
R11960 T13875 T13872 arg1Of data,these
R11961 T13875 T13874 arg1Of data,vitro
R11962 T13877 T13878 arg1Of impairment,of
R11963 T13877 T13882 arg1Of impairment,by
R11964 T13877 T13884 arg1Of impairment,may
R11965 T13877 T13891 arg1Of impairment,underlie
R11966 T13881 T13878 arg2Of import,of
R11967 T13881 T13879 arg1Of import,GATA-3
R11968 T13881 T13880 arg1Of import,nuclear
R11969 T13883 T13882 arg2Of FP,by
R11970 T13887 T13886 arg1Of least,at
R11971 T13888 T13887 arg1Of in,least
R11972 T13889 T13888 arg2Of part,in
R11973 T13890 T13869 arg1Of ",",As
R11974 T13890 T13876 arg1Of ",",","
R11975 T13891 T13890 arg2Of underlie,","
R11976 T13893 T13891 arg2Of efficacy,underlie
R11977 T13893 T13892 arg1Of efficacy,the
R11978 T13893 T13894 arg1Of efficacy,of
R11979 T13893 T13896 arg1Of efficacy,in
R11980 T13895 T13894 arg2Of corticosteroids,of
R11981 T13897 T13896 arg2Of suppressing,in
R11982 T13899 T13897 arg2Of inflammation,suppressing
R11983 T13899 T13898 arg1Of inflammation,allergic
R11984 T13901 T13902 arg1Of we,did
R11985 T13901 T13904 arg1Of we,assess
R11986 T13904 T13900 arg2Of assess,Although
R11987 T13904 T13902 arg2Of assess,did
R11988 T13904 T13903 arg1Of assess,not
R11989 T13904 T13918 arg1Of assess,vivo
R11990 T13907 T13906 arg1Of inhibitory,acute
R11991 T13908 T13904 arg2Of effect,assess
R11992 T13908 T13905 arg1Of effect,the
R11993 T13908 T13907 arg1Of effect,inhibitory
R11994 T13908 T13909 arg1Of effect,of
R11995 T13908 T13911 arg1Of effect,on
R11996 T13910 T13909 arg2Of FP,of
R11997 T13913 T13911 arg2Of expression,on
R11998 T13913 T13912 arg1Of expression,the
R11999 T13913 T13914 arg1Of expression,of
R12000 T13916 T13914 arg2Of mRNA,of
R12001 T13916 T13915 arg1Of mRNA,IL-4
R12002 T13918 T13917 arg1Of vivo,in
R12003 T13922 T13920 arg1Of inhalation,a
R12004 T13922 T13921 arg1Of inhalation,single
R12005 T13922 T13923 arg1Of inhalation,of
R12006 T13922 T13929 arg1Of inhalation,may
R12007 T13922 T13930 arg1Of inhalation,have
R12008 T13924 T13923 arg2Of FP,of
R12009 T13924 T13925 arg1Of FP,(
R12010 T13927 T13925 arg2Of µg,(
R12011 T13927 T13926 arg1Of µg,500
R12012 T13928 T13925 arg3Of ),(
R12013 T13930 T13900 arg1Of have,Although
R12014 T13930 T13919 arg1Of have,","
R12015 T13930 T13929 arg2Of have,may
R12016 T13930 T13933 arg1Of have,","
R12017 T13930 T13934 arg1Of have,as
R12018 T13932 T13930 arg2Of effects,have
R12019 T13932 T13931 arg1Of effects,comparable
R12020 T13935 T13936 arg1Of it,provides
R12021 T13936 T13934 arg2Of provides,as
R12022 T13936 T13939 arg1Of provides,within
R12023 T13938 T13936 arg2Of levels,provides
R12024 T13938 T13937 arg1Of levels,plasma
R12025 T13942 T13939 arg2Of range,within
R12026 T13942 T13940 arg1Of range,a
R12027 T13942 T13941 arg1Of range,relevant
R12028 T13942 T13943 arg1Of range,of
R12029 T13944 T13943 arg2Of concentrations,of
R12030 T13944 T13945 arg2Of concentrations,used
R12031 T13947 T13945 arg3Of suppress,used
R12032 T13947 T13946 arg1Of suppress,to
R12033 T13947 T13950 arg1Of suppress,in
R12034 T13949 T13947 arg2Of transcription,suppress
R12035 T13949 T13948 arg1Of transcription,IL-4
R12036 T13953 T13952 arg1Of vitro,in
R12037 T13954 T13950 arg2Of system,in
R12038 T13954 T13951 arg1Of system,our
R12039 T13954 T13953 arg1Of system,vitro
R12040 T13954 T13955 arg1Of system,[
R12041 T13956 T13955 arg2Of 37,[
R12042 T13957 T13955 arg3Of ],[
R12043 T13960 T13958 arg1Of dose,A
R12044 T13960 T13959 arg1Of dose,lower
R12045 T13960 T13961 arg1Of dose,of
R12046 T13960 T13968 arg1Of dose,was
R12047 T13960 T13970 arg1Of dose,effective
R12048 T13963 T13961 arg2Of FP,of
R12049 T13963 T13962 arg2Of FP,inhaled
R12050 T13963 T13964 arg1Of FP,(
R12051 T13966 T13964 arg2Of µg,(
R12052 T13966 T13965 arg1Of µg,100
R12053 T13967 T13964 arg3Of ),(
R12054 T13968 T13969 arg1Of was,not
R12055 T13968 T13972 arg1Of was,but
R12056 T13970 T13968 arg2Of effective,was
R12057 T13972 T13971 arg1Of but,","
R12058 T13974 T13973 arg1Of concentrations,plasma
R12059 T13974 T13975 arg1Of concentrations,may
R12060 T13974 T13976 arg1Of concentrations,be
R12061 T13974 T13977 arg1Of concentrations,below
R12062 T13976 T13972 arg2Of be,but
R12063 T13976 T13975 arg2Of be,may
R12064 T13977 T13976 arg2Of below,be
R12065 T13978 T13977 arg2Of those,below
R12066 T13978 T13979 arg2Of those,required
R12067 T13979 T13980 arg1Of required,for
R12068 T13982 T13980 arg2Of inhibition,for
R12069 T13982 T13981 arg1Of inhibition,GATA-3
R12070 T13985 T13986 arg1Of it,is
R12071 T13985 T13987 arg1Of it,likely
R12072 T13986 T13983 arg1Of is,However
R12073 T13986 T13984 arg1Of is,","
R12074 T13987 T13986 arg2Of likely,is
R12075 T13991 T13989 arg1Of concentrations,the
R12076 T13991 T13990 arg1Of concentrations,higher
R12077 T13991 T13992 arg1Of concentrations,of
R12078 T13991 T13994 arg1Of concentrations,in
R12079 T13991 T14000 arg1Of concentrations,would
R12080 T13991 T14001 arg1Of concentrations,be
R12081 T13991 T14002 arg1Of concentrations,effective
R12082 T13993 T13992 arg2Of FP,of
R12083 T13996 T13994 arg2Of airways,in
R12084 T13996 T13995 arg1Of airways,the
R12085 T13996 T13997 arg1Of airways,after
R12086 T13999 T13997 arg2Of administration,after
R12087 T13999 T13998 arg2Of administration,inhaled
R12088 T14001 T13987 arg2Of be,likely
R12089 T14001 T13988 arg1Of be,that
R12090 T14001 T14000 arg2Of be,would
R12091 T14002 T14001 arg2Of effective,be
R12092 T14002 T14003 arg1Of effective,in
R12093 T14004 T14003 arg2Of inhibiting,in
R12094 T14004 T14006 arg1Of inhibiting,in
R12095 T14005 T14004 arg2Of GATA-3,inhibiting
R12096 T14009 T14006 arg2Of cells,in
R12097 T14009 T14007 arg1Of cells,airway
R12098 T14009 T14008 arg1Of cells,T
R12099 T14009 T14010 arg1Of cells,of
R12100 T14012 T14010 arg2Of patients,of
R12101 T14012 T14011 arg1Of patients,asthma
R12102 T14014 T14013 arg1Of study,The
R12103 T14014 T14015 arg1Of study,of
R12104 T14014 T14026 arg1Of study,demonstrates
R12105 T14016 T14015 arg2Of PBMCs,of
R12106 T14016 T14017 arg1Of PBMCs,from
R12107 T14019 T14017 arg2Of patients,from
R12108 T14019 T14018 arg1Of patients,asthma
R12109 T14019 T14020 arg2Of patients,treated
R12110 T14020 T14021 arg1Of treated,with
R12111 T14024 T14021 arg2Of therapy,with
R12112 T14024 T14022 arg2Of therapy,inhaled
R12113 T14024 T14023 arg1Of therapy,corticosteroid
R12114 T14026 T14025 arg1Of demonstrates,clearly
R12115 T14030 T14028 arg1Of mechanisms,these
R12116 T14030 T14029 arg1Of mechanisms,molecular
R12117 T14030 T14031 arg1Of mechanisms,are
R12118 T14030 T14032 arg1Of mechanisms,likely
R12119 T14030 T14035 arg1Of mechanisms,occur
R12120 T14031 T14026 arg2Of are,demonstrates
R12121 T14031 T14027 arg1Of are,that
R12122 T14032 T14031 arg2Of likely,are
R12123 T14035 T14032 arg2Of occur,likely
R12124 T14035 T14033 arg1Of occur,to
R12125 T14035 T14034 arg1Of occur,also
R12126 T14035 T14036 arg1Of occur,in
R12127 T14037 T14036 arg2Of patients,in
R12128 T14037 T14038 arg1Of patients,at
R12129 T14040 T14038 arg2Of doses,at
R12130 T14040 T14039 arg1Of doses,therapeutic
R12131 T14040 T14041 arg1Of doses,of
R12132 T14043 T14041 arg2Of corticosteroids,of
R12133 T14043 T14042 arg2Of corticosteroids,inhaled
R12134 T14045 T14044 arg2Of addition,In
R12135 T14048 T14047 arg1Of studies,previous
R12136 T14048 T14049 arg1Of studies,have
R12137 T14048 T14050 arg1Of studies,shown
R12138 T14050 T14044 arg1Of shown,In
R12139 T14050 T14046 arg1Of shown,","
R12140 T14050 T14049 arg2Of shown,have
R12141 T14052 T14053 arg1Of corticosteroids,can
R12142 T14052 T14054 arg1Of corticosteroids,suppress
R12143 T14054 T14050 arg2Of suppress,shown
R12144 T14054 T14051 arg1Of suppress,that
R12145 T14054 T14053 arg2Of suppress,can
R12146 T14055 T14056 arg1Of IL-4,and
R12147 T14057 T14056 arg2Of IL-5,and
R12148 T14058 T14055 arg1Of release,IL-4
R12149 T14058 T14057 arg1Of release,IL-5
R12150 T14058 T14059 arg1Of release,from
R12151 T14058 T14067 arg1Of release,vitro
R12152 T14058 T14068 arg1Of release,and
R12153 T14062 T14059 arg2Of cells,from
R12154 T14062 T14060 arg1Of cells,peripheral
R12155 T14062 T14061 arg1Of cells,blood
R12156 T14062 T14063 arg1Of cells,of
R12157 T14065 T14063 arg2Of patients,of
R12158 T14065 T14064 arg1Of patients,asthma
R12159 T14067 T14066 arg1Of vitro,in
R12160 T14068 T14054 arg2Of and,suppress
R12161 T14070 T14069 arg1Of vivo,in
R12162 T14072 T14071 arg2Of 40,[
R12163 T14073 T14071 arg3Of ],[
R12164 T14074 T14068 arg2Of –,and
R12165 T14074 T14070 arg1Of –,vivo
R12166 T14074 T14071 arg1Of –,[
R12167 T14074 T14075 arg1Of –,[
R12168 T14076 T14075 arg2Of 42,[
R12169 T14077 T14075 arg3Of ],[
R12170 T14079 T14078 arg2Of summary,In
R12171 T14082 T14081 arg1Of data,our
R12172 T14082 T14083 arg1Of data,provide
R12173 T14083 T14078 arg1Of provide,In
R12174 T14083 T14080 arg1Of provide,","
R12175 T14083 T14096 arg1Of provide,through
R12176 T14083 T14116 arg1Of provide,by
R12177 T14084 T14083 arg2Of evidence,provide
R12178 T14084 T14085 arg1Of evidence,for
R12179 T14088 T14089 arg1Of action,of
R12180 T14090 T14089 arg2Of corticosteroids,of
R12181 T14090 T14091 arg1Of corticosteroids,:
R12182 T14092 T14085 arg2Of suppression,for
R12183 T14092 T14086 arg1Of suppression,a
R12184 T14092 T14087 arg1Of suppression,novel
R12185 T14092 T14088 arg1Of suppression,action
R12186 T14092 T14093 arg1Of suppression,of
R12187 T14095 T14093 arg2Of inflammation,of
R12188 T14095 T14094 arg1Of inflammation,allergic
R12189 T14096 T14115 arg1Of through,and
R12190 T14100 T14096 arg2Of effect,through
R12191 T14100 T14097 arg1Of effect,a
R12192 T14100 T14098 arg1Of effect,rapid
R12193 T14100 T14099 arg1Of effect,inhibitory
R12194 T14100 T14101 arg1Of effect,on
R12195 T14100 T14105 arg1Of effect,by
R12196 T14104 T14101 arg2Of translocation,on
R12197 T14104 T14102 arg1Of translocation,GATA-3
R12198 T14104 T14103 arg1Of translocation,nuclear
R12199 T14107 T14105 arg2Of binding,by
R12200 T14107 T14106 arg1Of binding,preferential
R12201 T14107 T14108 arg1Of binding,to
R12202 T14114 T14108 arg2Of importin-α,to
R12203 T14114 T14109 arg1Of importin-α,the
R12204 T14114 T14110 arg1Of importin-α,shared
R12205 T14114 T14111 arg1Of importin-α,nuclear
R12206 T14114 T14112 arg1Of importin-α,import
R12207 T14114 T14113 arg1Of importin-α,protein
R12208 T14116 T14115 arg2Of by,and
R12209 T14119 T14116 arg2Of mechanism,by
R12210 T14119 T14117 arg1Of mechanism,a
R12211 T14119 T14118 arg1Of mechanism,second
R12212 T14119 T14120 arg1Of mechanism,involving
R12213 T14122 T14120 arg2Of synthesis,involving
R12214 T14122 T14121 arg2Of synthesis,increased
R12215 T14122 T14123 arg1Of synthesis,of
R12216 T14122 T14125 arg1Of synthesis,","
R12217 T14122 T14126 arg1Of synthesis,which
R12218 T14122 T14127 arg1Of synthesis,inhibits
R12219 T14124 T14123 arg2Of MKP-1,of
R12220 T14127 T14130 arg1Of inhibits,","
R12221 T14127 T14132 modOf inhibits,preventing
R12222 T14129 T14127 arg2Of MAPK,inhibits
R12223 T14129 T14128 arg1Of MAPK,p38
R12224 T14132 T14131 arg1Of preventing,thus
R12225 T14134 T14132 arg2Of phosphorylation,preventing
R12226 T14134 T14133 arg1Of phosphorylation,the
R12227 T14134 T14135 arg1Of phosphorylation,of
R12228 T14134 T14137 arg1Of phosphorylation,that
R12229 T14134 T14138 arg1Of phosphorylation,is
R12230 T14134 T14139 arg1Of phosphorylation,necessary
R12231 T14136 T14135 arg2Of GATA-3,of
R12232 T14139 T14138 arg2Of necessary,is
R12233 T14139 T14140 arg1Of necessary,for
R12234 T14142 T14140 arg2Of translocation,for
R12235 T14142 T14141 arg1Of translocation,nuclear
R12236 T14142 T14143 arg1Of translocation,of
R12237 T14144 T14143 arg2Of GATA-3,of
R12238 T14147 T14145 arg1Of mechanisms,These
R12239 T14147 T14146 arg1Of mechanisms,two
R12240 T14147 T14148 arg1Of mechanisms,are
R12241 T14147 T14149 arg1Of mechanisms,likely
R12242 T14147 T14151 arg1Of mechanisms,be
R12243 T14147 T14152 arg1Of mechanisms,synergistic
R12244 T14147 T14154 arg1Of mechanisms,accounting
R12245 T14148 T14153 arg1Of are,","
R12246 T14148 T14154 modOf are,accounting
R12247 T14149 T14148 arg2Of likely,are
R12248 T14151 T14149 arg2Of be,likely
R12249 T14151 T14150 arg1Of be,to
R12250 T14152 T14151 arg2Of synergistic,be
R12251 T14154 T14155 arg1Of accounting,for
R12252 T14157 T14158 arg1Of rapid,and
R12253 T14159 T14158 arg2Of potent,and
R12254 T14160 T14155 arg2Of effect,for
R12255 T14160 T14156 arg1Of effect,the
R12256 T14160 T14157 arg1Of effect,rapid
R12257 T14160 T14159 arg1Of effect,potent
R12258 T14160 T14161 arg1Of effect,of
R12259 T14160 T14163 arg1Of effect,on
R12260 T14162 T14161 arg2Of corticosteroids,of
R12261 T14165 T14163 arg2Of inflammation,on
R12262 T14165 T14164 arg1Of inflammation,allergic
R12263 T14166 T14167 arg1Of This,is
R12264 T14166 T14168 arg2Of This,exemplified
R12265 T14168 T14167 arg2Of exemplified,is
R12266 T14173 T14168 arg1Of effect,exemplified
R12267 T14173 T14169 arg2Of effect,by
R12268 T14173 T14170 arg1Of effect,the
R12269 T14173 T14171 arg1Of effect,rapid
R12270 T14173 T14172 arg1Of effect,inhibitory
R12271 T14173 T14174 arg1Of effect,of
R12272 T14173 T14177 arg1Of effect,on
R12273 T14173 T14182 arg1Of effect,after
R12274 T14176 T14174 arg2Of corticosteroids,of
R12275 T14176 T14175 arg1Of corticosteroids,topical
R12276 T14181 T14177 arg2Of release,on
R12277 T14181 T14178 arg1Of release,nasal
R12278 T14181 T14179 arg1Of release,Th2
R12279 T14181 T14180 arg1Of release,cytokine
R12280 T14184 T14182 arg2Of provocation,after
R12281 T14184 T14183 arg1Of provocation,allergen
R12282 T14184 T14185 arg1Of provocation,in
R12283 T14186 T14185 arg2Of individuals,in
R12284 T14186 T14187 arg1Of individuals,with
R12285 T14190 T14187 arg2Of rhinitis,with
R12286 T14190 T14188 arg1Of rhinitis,seasonal
R12287 T14190 T14189 arg1Of rhinitis,allergic
R12288 T14190 T14191 arg1Of rhinitis,(
R12289 T14190 T14195 arg1Of rhinitis,[
R12290 T14193 T14191 arg2Of fever,(
R12291 T14193 T14192 arg1Of fever,hay
R12292 T14194 T14191 arg3Of ),(
R12293 T14196 T14195 arg2Of 43,[
R12294 T14197 T14195 arg3Of ],[
R12295 T14198 T14199 arg1Of Prevention,of
R12296 T14198 T14204 arg1Of Prevention,may
R12297 T14198 T14205 arg1Of Prevention,provide
R12298 T14201 T14199 arg2Of interaction,of
R12299 T14201 T14200 arg1Of interaction,phospho-GATA-3
R12300 T14201 T14202 arg1Of interaction,with
R12301 T14203 T14202 arg2Of importin-α,with
R12302 T14205 T14204 arg2Of provide,may
R12303 T14208 T14205 arg2Of approach,provide
R12304 T14208 T14206 arg1Of approach,a
R12305 T14208 T14207 arg1Of approach,new
R12306 T14208 T14209 arg1Of approach,for
R12307 T14211 T14209 arg2Of development,for
R12308 T14211 T14210 arg1Of development,the
R12309 T14211 T14212 arg1Of development,of
R12310 T14211 T14215 arg1Of development,for
R12311 T14214 T14212 arg2Of therapies,of
R12312 T14214 T14213 arg1Of therapies,novel
R12313 T14217 T14215 arg2Of treatment,for
R12314 T14217 T14216 arg1Of treatment,the
R12315 T14217 T14218 arg1Of treatment,of
R12316 T14220 T14218 arg2Of diseases,of
R12317 T14220 T14219 arg1Of diseases,allergic
R13756 T16039 T16038 arg1Of propionate,Fluticasone
R13757 T16039 T16040 arg1Of propionate,down-regulates
R13758 T16039 T16046 arg1Of propionate,inhibits
R13759 T16040 T16045 arg1Of down-regulates,and
R13760 T16044 T16040 arg2Of expression,down-regulates
R13761 T16044 T16041 arg1Of expression,Th2
R13762 T16044 T16042 arg1Of expression,cytokine
R13763 T16044 T16043 arg1Of expression,gene
R13764 T16046 T16045 arg2Of inhibits,and
R13765 T16049 T16046 arg2Of import,inhibits
R13766 T16049 T16047 arg1Of import,GATA-3
R13767 T16049 T16048 arg1Of import,nuclear
R13768 T16051 T16050 arg2Of A,(
R13769 T16052 T16050 arg3Of ),(
R13770 T16054 T16050 arg1Of treatment,(
R13771 T16054 T16053 arg1Of treatment,Anti-CD3/CD28
R13772 T16054 T16055 arg1Of treatment,of
R13773 T16054 T16058 arg1Of treatment,results
R13774 T16057 T16055 arg2Of cells,of
R13775 T16057 T16056 arg1Of cells,HuT-78
R13776 T16058 T16059 arg1Of results,in
R13777 T16058 T16066 arg1Of results,to
R13778 T16058 T16069 arg1Of results,within
R13779 T16058 T16077 arg1Of results,and
R13780 T16060 T16059 arg2Of translocation,in
R13781 T16060 T16061 arg1Of translocation,of
R13782 T16062 T16061 arg2Of GATA-3,of
R13783 T16062 T16063 arg1Of GATA-3,from
R13784 T16065 T16063 arg2Of cytoplasm,from
R13785 T16065 T16064 arg1Of cytoplasm,the
R13786 T16068 T16066 arg2Of nucleus,to
R13787 T16068 T16067 arg1Of nucleus,the
R13788 T16071 T16070 arg1Of min.,30
R13789 T16071 T16072 arg1Of min.,(
R13790 T16073 T16072 arg2Of B,(
R13791 T16074 T16072 arg3Of ),(
R13792 T16076 T16069 arg2Of H1,within
R13793 T16076 T16071 arg1Of H1,min.
R13794 T16076 T16075 arg1Of H1,Histone
R13795 T16078 T16079 arg1Of MEK-1,were
R13796 T16078 T16080 arg2Of MEK-1,used
R13797 T16080 T16077 arg2Of used,and
R13798 T16080 T16079 arg2Of used,were
R13799 T16082 T16080 arg3Of confirm,used
R13800 T16082 T16081 arg1Of confirm,to
R13801 T16084 T16082 arg2Of separation,confirm
R13802 T16084 T16083 arg1Of separation,distinct
R13803 T16084 T16085 arg1Of separation,of
R13804 T16084 T16090 arg1Of separation,in
R13805 T16084 T16104 modOf separation,demonstrated
R13806 T16086 T16087 arg1Of cytoplasmic,and
R13807 T16088 T16087 arg2Of nuclear,and
R13808 T16089 T16085 arg2Of extracts,of
R13809 T16089 T16086 arg1Of extracts,cytoplasmic
R13810 T16089 T16088 arg1Of extracts,nuclear
R13811 T16093 T16090 arg2Of experiments.,in
R13812 T16093 T16091 arg1Of experiments.,three
R13813 T16093 T16092 arg1Of experiments.,separate
R13814 T16093 T16094 arg1Of experiments.,(
R13815 T16095 T16094 arg2Of C,(
R13816 T16096 T16094 arg3Of ),(
R13817 T16099 T16097 arg1Of analysis,Western
R13818 T16099 T16098 arg1Of analysis,blot
R13819 T16099 T16100 arg1Of analysis,of
R13820 T16099 T16104 arg1Of analysis,demonstrated
R13821 T16103 T16100 arg2Of cells,of
R13822 T16103 T16101 arg1Of cells,FP-treated
R13823 T16103 T16102 arg1Of cells,HuT-78
R13824 T16106 T16105 arg1Of nuclear,impaired
R13825 T16107 T16104 arg2Of localization,demonstrated
R13826 T16107 T16106 arg1Of localization,nuclear
R13827 T16107 T16108 arg1Of localization,of
R13828 T16109 T16108 arg2Of GATA-3,of
R13829 T16109 T16110 arg2Of GATA-3,induced
R13830 T16113 T16112 arg1Of co-stimulation,anti-CD3/CD28
R13831 T16113 T16114 arg1Of co-stimulation,in
R13832 T16113 T16123 arg1Of co-stimulation,and
R13833 T16116 T16114 arg2Of time-,in
R13834 T16116 T16115 arg1Of time-,a
R13835 T16116 T16117 arg1Of time-,(
R13836 T16118 T16117 arg2Of at,(
R13837 T16119 T16120 arg1Of 10−8,M
R13838 T16121 T16118 arg2Of FP,at
R13839 T16121 T16119 arg1Of FP,10−8
R13840 T16122 T16117 arg3Of ),(
R13841 T16123 T16110 arg1Of and,induced
R13842 T16123 T16111 arg2Of and,by
R13843 T16124 T16125 arg1Of concentration-,(
R13844 T16126 T16125 arg2Of at,(
R13845 T16128 T16126 arg2Of min,at
R13846 T16128 T16127 arg1Of min,60
R13847 T16128 T16129 arg1Of min,after
R13848 T16130 T16129 arg2Of stimulation,after
R13849 T16131 T16125 arg3Of ),(
R13850 T16133 T16123 arg2Of manner,and
R13851 T16133 T16124 arg1Of manner,concentration-
R13852 T16133 T16132 arg1Of manner,dependent
R13853 T16134 T16135 arg1Of Cells,were
R13854 T16134 T16136 arg2Of Cells,pretreated
R13855 T16136 T16135 arg2Of pretreated,were
R13856 T16136 T16137 arg1Of pretreated,with
R13857 T16138 T16137 arg2Of FP,with
R13858 T16138 T16139 arg1Of FP,for
R13859 T16141 T16139 arg2Of min,for
R13860 T16141 T16140 arg1Of min,30
R13861 T16141 T16142 arg1Of min,prior
R13862 T16142 T16143 arg1Of prior,to
R13863 T16144 T16143 arg2Of stimulation,to
R13864 T16145 T16146 arg1Of MEK1,and
R13865 T16146 T16149 arg1Of and,were
R13866 T16146 T16150 arg2Of and,used
R13867 T16148 T16146 arg2Of H1,and
R13868 T16148 T16147 arg1Of H1,histone
R13869 T16150 T16149 arg2Of used,were
R13870 T16152 T16150 arg3Of demonstrate,used
R13871 T16152 T16151 arg1Of demonstrate,to
R13872 T16152 T16158 arg1Of demonstrate,respectively
R13873 T16154 T16155 arg1Of cytoplasmic,and
R13874 T16156 T16155 arg2Of nuclear,and
R13875 T16157 T16152 arg2Of loading,demonstrate
R13876 T16157 T16153 arg1Of loading,equal
R13877 T16157 T16154 arg1Of loading,cytoplasmic
R13878 T16157 T16156 arg1Of loading,nuclear
R13879 T16159 T16160 arg1Of Results,are
R13880 T16159 T16161 arg2Of Results,presented
R13881 T16161 T16160 arg2Of presented,are
R13882 T16161 T16163 arg1Of presented,below
R13883 T16161 T16164 arg1Of presented,as
R13884 T16161 T16176 arg1Of presented,compared
R13885 T16163 T16162 arg1Of below,graphically
R13886 T16165 T16164 arg2Of mean±SEM,as
R13887 T16165 T16166 arg1Of mean±SEM,of
R13888 T16169 T16167 arg1Of three,at
R13889 T16169 T16168 arg1Of three,least
R13890 T16171 T16166 arg2Of experiments.,of
R13891 T16171 T16169 arg1Of experiments.,three
R13892 T16171 T16170 arg1Of experiments.,independent
R13893 T16173 T16164 arg3Of p,as
R13894 T16173 T16172 arg1Of p,***
R13895 T16173 T16174 arg1Of p,<
R13896 T16175 T16161 arg3Of 0.001,presented
R13897 T16177 T16176 arg2Of to,compared
R13898 T16180 T16179 arg2Of D,(
R13899 T16181 T16179 arg3Of ),(
R13900 T16182 T16177 arg2Of RT-PCR,to
R13901 T16182 T16178 arg1Of RT-PCR,t = 0.
R13902 T16182 T16179 arg1Of RT-PCR,(
R13903 T16182 T16183 arg1Of RT-PCR,showing
R13904 T16185 T16186 arg1Of FP,inhibits
R13905 T16186 T16183 arg2Of inhibits,showing
R13906 T16186 T16184 arg1Of inhibits,that
R13907 T16187 T16188 arg1Of IL-4,and
R13908 T16189 T16188 arg2Of IL-5,and
R13909 T16191 T16186 arg2Of expression,inhibits
R13910 T16191 T16187 arg1Of expression,IL-4
R13911 T16191 T16189 arg1Of expression,IL-5
R13912 T16191 T16190 arg1Of expression,mRNA
R13913 T16191 T16192 arg1Of expression,in
R13914 T16194 T16192 arg2Of cells,in
R13915 T16194 T16193 arg1Of cells,CD3/CD28-costimulated
R13916 T16195 T16196 arg1Of GAPDH,was
R13917 T16195 T16197 arg2Of GAPDH,used
R13918 T16197 T16196 arg2Of used,was
R13919 T16197 T16198 arg1Of used,as
R13920 T16201 T16198 arg2Of control,as
R13921 T16201 T16199 arg1Of control,a
R13922 T16201 T16200 arg1Of control,loading
R13923 T16203 T16202 arg1Of panels,Lower
R13924 T16203 T16204 arg1Of panels,show
R13925 T16203 T16228 arg1Of panels,***p
R13926 T16204 T16227 arg1Of show,","
R13927 T16204 T16228 modOf show,***p
R13928 T16206 T16204 arg2Of analysis,show
R13929 T16206 T16205 arg1Of analysis,graphical
R13930 T16206 T16207 arg1Of analysis,of
R13931 T16208 T16207 arg2Of results,of
R13932 T16208 T16209 arg2Of results,presented
R13933 T16209 T16210 arg1Of presented,as
R13934 T16211 T16210 arg2Of mean±SEM,as
R13935 T16211 T16212 arg1Of mean±SEM,of
R13936 T16215 T16213 arg1Of three,at
R13937 T16215 T16214 arg1Of three,least
R13938 T16217 T16215 arg1Of experiments.,three
R13939 T16217 T16216 arg1Of experiments.,independent
R13940 T16221 T16217 arg1Of p,experiments.
R13941 T16221 T16218 arg1Of p,#
R13942 T16221 T16219 arg1Of p,#
R13943 T16221 T16220 arg1Of p,#
R13944 T16221 T16222 arg1Of p,<
R13945 T16223 T16212 arg2Of 0.001,of
R13946 T16223 T16221 arg1Of 0.001,p
R13947 T16223 T16224 arg1Of 0.001,compared
R13948 T16225 T16224 arg2Of to,compared
R13949 T16226 T16225 arg2Of control,to
R13950 T16230 T16231 arg1Of 0.001,compared
R13951 T16232 T16231 arg2Of to,compared
R13952 T16233 T16232 arg2Of anti-CD3/CD28–stimulated.,to
R13953 T16233 T16234 arg1Of anti-CD3/CD28–stimulated.,(
R13954 T16235 T16234 arg2Of E,(
R13955 T16236 T16234 arg3Of ),(
R13956 T16237 T16229 arg1Of FP,<
R13957 T16237 T16230 arg1Of FP,0.001
R13958 T16237 T16238 arg1Of FP,(
R13959 T16237 T16242 arg1Of FP,reduces
R13960 T16240 T16238 arg2Of nM,(
R13961 T16240 T16239 arg1Of nM,10
R13962 T16241 T16238 arg3Of ),(
R13963 T16242 T16228 arg2Of reduces,***p
R13964 T16244 T16242 arg2Of ability,reduces
R13965 T16244 T16243 arg1Of ability,the
R13966 T16244 T16245 arg1Of ability,of
R13967 T16244 T16248 modOf ability,to
R13968 T16247 T16245 arg2Of GATA-3,of
R13969 T16247 T16246 arg1Of GATA-3,anti-CD3/CD28-stimulated
R13970 T16249 T16248 arg1Of associate,to
R13971 T16249 T16250 arg1Of associate,with
R13972 T16256 T16250 arg2Of min,with
R13973 T16256 T16251 arg1Of min,the
R13974 T16256 T16252 arg1Of min,native
R13975 T16256 T16253 arg1Of min,IL-5
R13976 T16256 T16254 arg1Of min,promoter
R13977 T16256 T16255 arg1Of min,60
R13978 T16256 T16257 arg1Of min,after
R13979 T16258 T16257 arg2Of stimulation,after
R13980 T16259 T16260 arg1Of Data,are
R13981 T16259 T16262 arg2Of Data,shown
R13982 T16262 T16260 arg2Of shown,are
R13983 T16262 T16261 arg1Of shown,also
R13984 T16262 T16263 arg1Of shown,graphically
R13985 T16262 T16264 arg1Of shown,as
R13986 T16265 T16264 arg2Of mean±SEM,as
R13987 T16265 T16266 arg1Of mean±SEM,of
R13988 T16269 T16266 arg2Of experiments,of
R13989 T16269 T16267 arg1Of experiments,three
R13990 T16269 T16268 arg1Of experiments,independent
R13991 T16271 T16270 arg1Of data,All
R13992 T16271 T16272 arg1Of data,were
R13993 T16271 T16273 arg2Of data,analysed
R13994 T16273 T16272 arg2Of analysed,were
R13995 T16275 T16273 arg1Of ANOVA,analysed
R13996 T16275 T16274 arg2Of ANOVA,by
R13997 T16275 T16276 arg2Of ANOVA,followed
R13998 T16278 T16276 arg1Of Newman-Keuls,followed
R13999 T16278 T16277 arg2Of Newman-Keuls,by
R14000 T16278 T16279 arg1Of Newman-Keuls,post-test
R14410 T16827 T16826 arg1Of propionate,Fluticasone
R14411 T16827 T16828 arg1Of propionate,reduces
R14412 T16830 T16828 arg2Of association,reduces
R14413 T16830 T16829 arg1Of association,GATA-3
R14414 T16830 T16831 arg1Of association,with
R14415 T16832 T16833 arg1Of importin-α,and
R14416 T16833 T16831 arg2Of and,with
R14417 T16836 T16833 arg2Of import,and
R14418 T16836 T16834 arg1Of import,GATA-3
R14419 T16836 T16835 arg1Of import,nuclear
R14420 T16838 T16837 arg2Of A,(
R14421 T16839 T16837 arg3Of ),(
R14422 T16842 T16837 arg1Of analysis,(
R14423 T16842 T16840 arg1Of analysis,Western
R14424 T16842 T16841 arg1Of analysis,blot
R14425 T16842 T16843 arg1Of analysis,demonstrates
R14426 T16845 T16844 arg1Of time-,a
R14427 T16845 T16846 arg1Of time-,(
R14428 T16845 T16852 arg1Of time-,and
R14429 T16847 T16846 arg2Of at,(
R14430 T16848 T16849 arg1Of 10−8,M
R14431 T16850 T16847 arg2Of FP,at
R14432 T16850 T16848 arg1Of FP,10−8
R14433 T16851 T16846 arg3Of ),(
R14434 T16852 T16843 arg2Of and,demonstrates
R14435 T16853 T16854 arg1Of concentration-,(
R14436 T16855 T16854 arg2Of at,(
R14437 T16857 T16855 arg2Of min,at
R14438 T16857 T16856 arg1Of min,60
R14439 T16857 T16858 arg1Of min,after
R14440 T16859 T16858 arg2Of stimulation,after
R14441 T16860 T16854 arg3Of ),(
R14442 T16862 T16852 arg2Of induction,and
R14443 T16862 T16853 arg1Of induction,concentration-
R14444 T16862 T16861 arg1Of induction,dependent
R14445 T16862 T16863 arg1Of induction,of
R14446 T16866 T16863 arg2Of interaction,of
R14447 T16866 T16864 arg1Of interaction,FP-activated
R14448 T16866 T16865 arg1Of interaction,GR
R14449 T16866 T16867 arg1Of interaction,with
R14450 T16868 T16867 arg2Of importin-α,with
R14451 T16868 T16869 arg1Of importin-α,(
R14452 T16870 T16869 arg2Of Imp-α,(
R14453 T16871 T16869 arg3Of ),(
R14454 T16874 T16872 arg1Of control,A
R14455 T16874 T16873 arg1Of control,positive
R14456 T16874 T16875 arg1Of control,for
R14457 T16874 T16880 arg1Of control,is
R14458 T16874 T16881 arg2Of control,shown
R14459 T16877 T16875 arg2Of association,for
R14460 T16877 T16876 arg1Of association,GR
R14461 T16877 T16878 arg1Of association,with
R14462 T16879 T16878 arg2Of importin,with
R14463 T16881 T16880 arg2Of shown,is
R14464 T16882 T16883 arg1Of Quantification,of
R14465 T16882 T16887 arg1Of Quantification,is
R14466 T16882 T16888 arg2Of Quantification,shown
R14467 T16886 T16883 arg2Of data,of
R14468 T16886 T16884 arg1Of data,the
R14469 T16886 T16885 arg1Of data,densitometry
R14470 T16888 T16887 arg2Of shown,is
R14471 T16888 T16889 arg1Of shown,below
R14472 T16891 T16890 arg1Of bar,Each
R14473 T16891 T16892 arg1Of bar,represents
R14474 T16893 T16892 arg2Of mean±SEM,represents
R14475 T16893 T16894 arg1Of mean±SEM,of
R14476 T16897 T16895 arg1Of three,at
R14477 T16897 T16896 arg1Of three,least
R14478 T16899 T16894 arg2Of experiments.,of
R14479 T16899 T16897 arg1Of experiments.,three
R14480 T16899 T16898 arg1Of experiments.,independent
R14481 T16902 T16900 arg1Of <,***
R14482 T16902 T16901 arg1Of <,p
R14483 T16903 T16892 arg3Of 0.001,represents
R14484 T16903 T16902 arg1Of 0.001,<
R14485 T16903 T16904 arg1Of 0.001,compared
R14486 T16903 T16945 arg2Of 0.001,measured
R14487 T16905 T16904 arg2Of to,compared
R14488 T16906 T16905 arg2Of control,to
R14489 T16906 T16907 arg1Of control,","
R14490 T16906 T16912 arg1Of control,<
R14491 T16911 T16907 arg2Of p,","
R14492 T16911 T16908 arg1Of p,#
R14493 T16911 T16909 arg1Of p,#
R14494 T16911 T16910 arg1Of p,#
R14495 T16915 T16914 arg2Of B,(
R14496 T16916 T16914 arg3Of ),(
R14497 T16919 T16913 arg1Of analysis,0.001.
R14498 T16919 T16914 arg1Of analysis,(
R14499 T16919 T16917 arg1Of analysis,Western
R14500 T16919 T16918 arg1Of analysis,blot
R14501 T16919 T16920 arg1Of analysis,demonstrated
R14502 T16922 T16921 arg1Of time-,a
R14503 T16922 T16923 arg1Of time-,(
R14504 T16922 T16929 arg1Of time-,and
R14505 T16924 T16923 arg2Of at,(
R14506 T16925 T16926 arg1Of 10−8,M
R14507 T16927 T16924 arg2Of FP,at
R14508 T16927 T16925 arg1Of FP,10−8
R14509 T16928 T16923 arg3Of ),(
R14510 T16929 T16920 arg2Of and,demonstrated
R14511 T16930 T16931 arg1Of concentration-,(
R14512 T16932 T16931 arg2Of at,(
R14513 T16934 T16932 arg2Of min,at
R14514 T16934 T16933 arg1Of min,60
R14515 T16934 T16935 arg1Of min,after
R14516 T16936 T16935 arg2Of stimulation,after
R14517 T16937 T16931 arg3Of ),(
R14518 T16939 T16929 arg2Of induction,and
R14519 T16939 T16930 arg1Of induction,concentration-
R14520 T16939 T16938 arg1Of induction,dependent
R14521 T16939 T16940 arg1Of induction,of
R14522 T16944 T16940 arg2Of translocation,of
R14523 T16944 T16941 arg1Of translocation,FP-activated
R14524 T16944 T16942 arg1Of translocation,GR
R14525 T16944 T16943 arg1Of translocation,nuclear
R14526 T16945 T16920 arg3Of measured,demonstrated
R14527 T16947 T16945 arg1Of IP,measured
R14528 T16947 T16946 arg2Of IP,by
R14529 T16948 T16949 arg1Of Quantification,of
R14530 T16948 T16953 arg1Of Quantification,is
R14531 T16948 T16954 arg2Of Quantification,shown
R14532 T16952 T16949 arg2Of data,of
R14533 T16952 T16950 arg1Of data,the
R14534 T16952 T16951 arg1Of data,densitometry
R14535 T16954 T16953 arg2Of shown,is
R14536 T16954 T16955 arg1Of shown,below
R14537 T16957 T16956 arg1Of bar,Each
R14538 T16957 T16958 arg1Of bar,represents
R14539 T16958 T16984 arg1Of represents,and
R14540 T16959 T16958 arg2Of mean±SEM,represents
R14541 T16959 T16960 arg1Of mean±SEM,of
R14542 T16963 T16961 arg1Of three,at
R14543 T16963 T16962 arg1Of three,least
R14544 T16965 T16963 arg1Of experiments.,three
R14545 T16965 T16964 arg1Of experiments.,independent
R14546 T16965 T16966 arg1Of experiments.,***p
R14547 T16966 T16969 arg1Of ***p,compared
R14548 T16968 T16966 arg2Of 0.001,***p
R14549 T16968 T16967 arg1Of 0.001,<
R14550 T16970 T16969 arg2Of to,compared
R14551 T16971 T16970 arg2Of control.,to
R14552 T16971 T16972 arg1Of control.,(
R14553 T16973 T16972 arg2Of C,(
R14554 T16974 T16972 arg3Of ),(
R14555 T16977 T16960 arg2Of analysis,of
R14556 T16977 T16965 arg1Of analysis,experiments.
R14557 T16977 T16975 arg1Of analysis,Western
R14558 T16977 T16976 arg1Of analysis,blot
R14559 T16977 T16978 arg1Of analysis,of
R14560 T16980 T16978 arg2Of cells,of
R14561 T16980 T16979 arg1Of cells,HuT-78
R14562 T16980 T16981 arg2Of cells,treated
R14563 T16981 T16982 arg1Of treated,with
R14564 T16983 T16982 arg2Of FP,with
R14565 T16986 T16985 arg1Of co-stimulation,anti-CD3/CD28
R14566 T16986 T16987 arg1Of co-stimulation,demonstrated
R14567 T16987 T16984 arg2Of demonstrated,and
R14568 T16987 T16994 arg1Of demonstrated,at
R14569 T16990 T16987 arg2Of decrease,demonstrated
R14570 T16990 T16988 arg1Of decrease,a
R14571 T16990 T16989 arg1Of decrease,concentration-dependent
R14572 T16990 T16991 arg1Of decrease,in
R14573 T16993 T16991 arg2Of association,in
R14574 T16993 T16992 arg1Of association,GATA-3–importin-α
R14575 T16996 T16994 arg2Of min,at
R14576 T16996 T16995 arg1Of min,20
R14577 T16997 T16998 arg1Of Quantification,of
R14578 T16997 T17002 arg1Of Quantification,is
R14579 T16997 T17003 arg2Of Quantification,shown
R14580 T17001 T16998 arg2Of data,of
R14581 T17001 T16999 arg1Of data,the
R14582 T17001 T17000 arg1Of data,densitometry
R14583 T17003 T17002 arg2Of shown,is
R14584 T17003 T17004 arg1Of shown,below
R14585 T17006 T17005 arg1Of bar,Each
R14586 T17006 T17007 arg1Of bar,represents
R14587 T17006 T17025 arg1Of bar,***p
R14588 T17007 T17020 arg1Of represents,0.001
R14589 T17007 T17021 arg1Of represents,compared
R14590 T17007 T17024 arg1Of represents,","
R14591 T17007 T17025 modOf represents,***p
R14592 T17008 T17007 arg2Of mean±SEM,represents
R14593 T17008 T17009 arg1Of mean±SEM,of
R14594 T17012 T17010 arg1Of three,at
R14595 T17012 T17011 arg1Of three,least
R14596 T17014 T17009 arg2Of experiments.,of
R14597 T17014 T17012 arg1Of experiments.,three
R14598 T17014 T17013 arg1Of experiments.,independent
R14599 T17018 T17015 arg1Of p,#
R14600 T17018 T17016 arg1Of p,#
R14601 T17018 T17017 arg1Of p,#
R14602 T17018 T17019 arg1Of p,<
R14603 T17020 T17018 arg1Of 0.001,p
R14604 T17022 T17021 arg2Of to,compared
R14605 T17023 T17022 arg2Of control,to
R14606 T17027 T17028 arg1Of 0.001,compared
R14607 T17029 T17028 arg2Of to,compared
R14608 T17031 T17029 arg2Of cells.,to
R14609 T17031 T17030 arg1Of cells.,αCD3/CD28-stimulated
R14610 T17031 T17032 arg1Of cells.,(
R14611 T17033 T17032 arg2Of D,(
R14612 T17034 T17032 arg3Of ),(
R14613 T17036 T17026 arg1Of GATA-3,<
R14614 T17036 T17027 arg1Of GATA-3,0.001
R14615 T17036 T17035 arg1Of GATA-3,GFP-tagged
R14616 T17036 T17037 arg1Of GATA-3,was
R14617 T17036 T17038 arg2Of GATA-3,overexpressed
R14618 T17038 T17025 arg2Of overexpressed,***p
R14619 T17038 T17037 arg2Of overexpressed,was
R14620 T17040 T17039 arg1Of cells,and
R14621 T17040 T17041 arg2Of cells,stimulated
R14622 T17040 T17042 arg1Of cells,(
R14623 T17040 T17047 arg1Of cells,or
R14624 T17043 T17042 arg2Of b,(
R14625 T17043 T17044 arg1Of b,","
R14626 T17045 T17044 arg2Of c,","
R14627 T17046 T17042 arg3Of ),(
R14628 T17047 T17007 arg3Of or,represents
R14629 T17047 T17048 arg1Of or,not
R14630 T17050 T17051 arg1Of a,)
R14631 T17050 T17052 arg1Of a,for
R14632 T17054 T17052 arg2Of min,for
R14633 T17054 T17053 arg1Of min,30
R14634 T17056 T17047 arg2Of anti-CD3/CD28,or
R14635 T17056 T17049 arg1Of anti-CD3/CD28,(
R14636 T17056 T17050 arg1Of anti-CD3/CD28,a
R14637 T17056 T17055 arg1Of anti-CD3/CD28,with
R14638 T17058 T17057 arg1Of effect,The
R14639 T17058 T17059 arg1Of effect,of
R14640 T17058 T17073 arg1Of effect,is
R14641 T17058 T17075 arg2Of effect,shown
R14642 T17062 T17059 arg2Of pretreatment,of
R14643 T17062 T17060 arg1Of pretreatment,30
R14644 T17062 T17061 arg1Of pretreatment,min
R14645 T17062 T17063 arg1Of pretreatment,of
R14646 T17062 T17065 arg1Of pretreatment,with
R14647 T17064 T17063 arg2Of cells,of
R14648 T17066 T17065 arg2Of FP,with
R14649 T17066 T17067 arg1Of FP,(
R14650 T17069 T17067 arg2Of M,(
R14651 T17069 T17068 arg1Of M,10−8
R14652 T17069 T17070 arg1Of M,","
R14653 T17071 T17070 arg2Of c,","
R14654 T17072 T17067 arg3Of ),(
R14655 T17075 T17073 arg2Of shown,is
R14656 T17075 T17074 arg1Of shown,also
R14657 T17077 T17076 arg1Of data,All
R14658 T17077 T17078 arg1Of data,were
R14659 T17077 T17079 arg2Of data,analysed
R14660 T17079 T17078 arg2Of analysed,were
R14661 T17081 T17079 arg1Of ANOVA,analysed
R14662 T17081 T17080 arg2Of ANOVA,by
R14663 T17081 T17082 arg2Of ANOVA,followed
R14664 T17084 T17082 arg1Of Newman-Keuls,followed
R14665 T17084 T17083 arg2Of Newman-Keuls,by
R14666 T17084 T17085 arg1Of Newman-Keuls,post-test
R15109 T17625 T17624 arg1Of down-regulation,marked
R15094 T17610 T17611 arg1Of Fluticasone,propionate–mediated
R15095 T17611 T17618 arg1Of propionate–mediated,and
R15096 T17612 T17611 arg2Of inhibition,propionate–mediated
R15097 T17612 T17613 arg1Of inhibition,of
R15098 T17617 T17613 arg2Of phosphorylation,of
R15099 T17617 T17614 arg1Of phosphorylation,p38
R15100 T17617 T17615 arg1Of phosphorylation,MAP
R15101 T17617 T17616 arg1Of phosphorylation,kinase
R15102 T17619 T17620 arg1Of activation,is
R15103 T17619 T17621 arg2Of activation,associated
R15104 T17621 T17618 arg2Of associated,and
R15105 T17621 T17620 arg2Of associated,is
R15106 T17621 T17622 arg1Of associated,with
R15107 T17625 T17622 arg2Of down-regulation,with
R15108 T17625 T17623 arg1Of down-regulation,a
R15110 T17625 T17626 arg1Of down-regulation,of
R15111 T17629 T17626 arg2Of phosphorylation,of
R15112 T17629 T17627 arg1Of phosphorylation,GATA-3
R15113 T17629 T17628 arg1Of phosphorylation,serine
R15114 T17631 T17630 arg2Of A,(
R15115 T17632 T17630 arg3Of ),(
R15116 T17635 T17630 arg1Of analysis,(
R15117 T17635 T17633 arg1Of analysis,Western
R15118 T17635 T17634 arg1Of analysis,blot
R15119 T17635 T17636 arg1Of analysis,shows
R15120 T17638 T17639 arg1Of FP,(
R15121 T17641 T17639 arg2Of M,(
R15122 T17641 T17640 arg1Of M,10−8
R15123 T17641 T17642 arg1Of M,","
R15124 T17644 T17642 arg2Of min,","
R15125 T17644 T17643 arg1Of min,30
R15126 T17645 T17639 arg3Of ),(
R15127 T17646 T17638 arg1Of treatment,FP
R15128 T17646 T17647 arg1Of treatment,reduced
R15129 T17647 T17636 arg2Of reduced,shows
R15130 T17647 T17637 arg1Of reduced,that
R15131 T17649 T17647 arg2Of phosphorylation,reduced
R15132 T17649 T17648 arg1Of phosphorylation,dual
R15133 T17649 T17650 arg1Of phosphorylation,(
R15134 T17651 T17652 arg1Of threonine-180,and
R15135 T17652 T17650 arg2Of and,(
R15136 T17653 T17652 arg2Of tyrosine-182,and
R15137 T17654 T17650 arg3Of ),(
R15138 T17657 T17655 arg2Of MAPK,of
R15139 T17657 T17656 arg1Of MAPK,p38
R15140 T17661 T17658 arg2Of cells.,in
R15141 T17661 T17659 arg1Of cells.,anti-CD3/CD28–co-stimulated
R15142 T17661 T17660 arg1Of cells.,HuT-78
R15143 T17661 T17662 arg1Of cells.,(
R15144 T17663 T17662 arg2Of B,(
R15145 T17664 T17662 arg3Of ),(
R15146 T17666 T17665 arg1Of course,Time
R15147 T17666 T17667 arg1Of course,of
R15148 T17666 T17702 arg1Of course,is
R15149 T17666 T17703 arg2Of course,associated
R15150 T17669 T17667 arg2Of effect,of
R15151 T17669 T17668 arg1Of effect,the
R15152 T17669 T17670 arg1Of effect,of
R15153 T17669 T17676 arg1Of effect,on
R15154 T17669 T17678 arg1Of effect,of
R15155 T17671 T17670 arg2Of FP,of
R15156 T17671 T17672 arg1Of FP,(
R15157 T17674 T17672 arg2Of M,(
R15158 T17674 T17673 arg1Of M,10−8
R15159 T17675 T17672 arg3Of ),(
R15160 T17677 T17676 arg2Of phosphorylation,on
R15161 T17681 T17678 arg2Of factor,of
R15162 T17681 T17679 arg2Of factor,activated
R15163 T17681 T17680 arg1Of factor,transcription
R15164 T17681 T17682 arg1Of factor,2
R15165 T17681 T17683 arg1Of factor,(
R15166 T17681 T17686 arg1Of factor,","
R15167 T17684 T17683 arg2Of ATF-2,(
R15168 T17685 T17683 arg3Of ),(
R15169 T17688 T17686 arg2Of measure,","
R15170 T17688 T17687 arg1Of measure,a
R15171 T17688 T17689 arg1Of measure,of
R15172 T17694 T17693 arg2Of C,(
R15173 T17695 T17693 arg3Of ),(
R15174 T17697 T17689 arg2Of inhibition,of
R15175 T17697 T17690 arg1Of inhibition,p38
R15176 T17697 T17691 arg1Of inhibition,MAPK
R15177 T17697 T17692 arg1Of inhibition,activity.
R15178 T17697 T17693 arg1Of inhibition,(
R15179 T17697 T17696 arg1Of inhibition,FP-induced
R15180 T17697 T17698 arg1Of inhibition,of
R15181 T17701 T17698 arg2Of activity,of
R15182 T17701 T17699 arg1Of activity,p38
R15183 T17701 T17700 arg1Of activity,MAPK
R15184 T17703 T17702 arg2Of associated,is
R15185 T17703 T17704 arg1Of associated,with
R15186 T17706 T17704 arg2Of decrease,with
R15187 T17706 T17705 arg1Of decrease,the
R15188 T17706 T17707 arg1Of decrease,of
R15189 T17711 T17707 arg2Of phosphorylation,of
R15190 T17711 T17708 arg1Of phosphorylation,anti-CD3/CD28
R15191 T17711 T17709 arg1Of phosphorylation,co-stimulation–induced
R15192 T17711 T17710 arg1Of phosphorylation,serine
R15193 T17711 T17712 arg1Of phosphorylation,(
R15194 T17711 T17715 arg1Of phosphorylation,of
R15195 T17713 T17712 arg2Of P-Ser,(
R15196 T17714 T17712 arg3Of ),(
R15197 T17716 T17715 arg2Of GATA-3,of
R15198 T17719 T17717 arg2Of A–C,For
R15199 T17719 T17718 arg2Of A–C,(
R15200 T17720 T17718 arg3Of ),(
R15201 T17722 T17723 arg1Of quantification,of
R15202 T17722 T17727 arg1Of quantification,is
R15203 T17722 T17729 arg2Of quantification,shown
R15204 T17726 T17723 arg2Of data,of
R15205 T17726 T17724 arg1Of data,the
R15206 T17726 T17725 arg1Of data,densitometry
R15207 T17729 T17717 arg1Of shown,For
R15208 T17729 T17721 arg1Of shown,","
R15209 T17729 T17727 arg2Of shown,is
R15210 T17729 T17728 arg1Of shown,also
R15211 T17731 T17730 arg1Of bar,Each
R15212 T17731 T17732 arg1Of bar,represents
R15213 T17731 T17750 arg1Of bar,***p
R15214 T17732 T17750 modOf represents,***p
R15215 T17733 T17732 arg2Of mean±SEM,represents
R15216 T17733 T17734 arg1Of mean±SEM,of
R15217 T17737 T17735 arg1Of three,at
R15218 T17737 T17736 arg1Of three,least
R15219 T17739 T17737 arg1Of experiments.,three
R15220 T17739 T17738 arg1Of experiments.,independent
R15221 T17743 T17734 arg2Of p,of
R15222 T17743 T17739 arg1Of p,experiments.
R15223 T17743 T17740 arg1Of p,#
R15224 T17743 T17741 arg1Of p,#
R15225 T17743 T17742 arg1Of p,#
R15226 T17745 T17732 arg3Of 0.001,represents
R15227 T17745 T17744 arg1Of 0.001,<
R15228 T17745 T17746 arg1Of 0.001,compared
R15229 T17747 T17746 arg2Of to,compared
R15230 T17748 T17747 arg2Of control,to
R15231 T17750 T17749 arg1Of ***p,","
R15232 T17752 T17753 arg1Of 0.001,compared
R15233 T17754 T17753 arg2Of to,compared
R15234 T17756 T17754 arg2Of cells.,to
R15235 T17756 T17755 arg1Of cells.,αCD3/CD28-stimulated
R15236 T17756 T17757 arg1Of cells.,(
R15237 T17758 T17757 arg2Of D,(
R15238 T17759 T17757 arg3Of ),(
R15239 T17760 T17751 arg1Of FP,<
R15240 T17760 T17752 arg1Of FP,0.001
R15241 T17760 T17761 arg1Of FP,induced
R15242 T17761 T17750 arg2Of induced,***p
R15243 T17761 T17764 arg1Of induced,in
R15244 T17763 T17761 arg2Of mRNA,induced
R15245 T17763 T17762 arg1Of mRNA,MKP-1
R15246 T17767 T17764 arg2Of manner,in
R15247 T17767 T17765 arg1Of manner,a
R15248 T17767 T17766 arg1Of manner,concentration-dependent
R15249 T17769 T17768 arg1Of results,All
R15250 T17769 T17770 arg1Of results,are
R15251 T17769 T17771 arg1Of results,representative
R15252 T17771 T17770 arg2Of representative,are
R15253 T17771 T17772 arg1Of representative,of
R15254 T17775 T17773 arg1Of three,at
R15255 T17775 T17774 arg1Of three,least
R15256 T17777 T17775 arg1Of experiments,three
R15257 T17777 T17776 arg1Of experiments,independent
R15258 T17777 T17778 arg1Of experiments,and
R15259 T17778 T17772 arg2Of and,of
R15260 T17779 T17778 arg2Of where,and
R15261 T17781 T17782 arg1Of expressed,as
R15262 T17783 T17782 arg2Of means±SEM,as
R15263 T17783 T17784 arg1Of means±SEM,","
R15264 T17785 T17784 arg2Of *p,","
R15265 T17785 T17786 arg1Of *p,<
R15266 T17789 T17788 arg2Of E,(
R15267 T17790 T17788 arg3Of ),(
R15268 T17791 T17780 arg1Of FP,appropriate
R15269 T17791 T17781 arg2Of FP,expressed
R15270 T17791 T17787 arg1Of FP,0.05.
R15271 T17791 T17788 arg1Of FP,(
R15272 T17791 T17792 arg1Of FP,induces
R15273 T17792 T17779 arg1Of induces,where
R15274 T17792 T17795 arg1Of induces,in
R15275 T17794 T17792 arg2Of mRNA,induces
R15276 T17794 T17793 arg1Of mRNA,MKP-1
R15277 T17798 T17795 arg2Of manner,in
R15278 T17798 T17796 arg1Of manner,a
R15279 T17798 T17797 arg1Of manner,time-dependent
R15280 T17799 T17800 arg1Of Results,are
R15281 T17799 T17801 arg1Of Results,representative
R15282 T17801 T17800 arg2Of representative,are
R15283 T17801 T17802 arg1Of representative,of
R15284 T17805 T17802 arg2Of experiments,of
R15285 T17805 T17803 arg1Of experiments,two
R15286 T17805 T17804 arg1Of experiments,independent
R15287 T17807 T17806 arg1Of data,All
R15288 T17807 T17808 arg1Of data,except
R15289 T17807 T17809 arg1Of data,(
R15290 T17807 T17812 arg1Of data,were
R15291 T17807 T17813 arg2Of data,analysed
R15292 T17810 T17809 arg2Of E,(
R15293 T17811 T17809 arg3Of ),(
R15294 T17813 T17812 arg2Of analysed,were
R15295 T17815 T17813 arg1Of ANOVA,analysed
R15296 T17815 T17814 arg2Of ANOVA,by
R15297 T17815 T17816 arg2Of ANOVA,followed
R15298 T17818 T17816 arg1Of Newman-Keuls,followed
R15299 T17818 T17817 arg2Of Newman-Keuls,by
R15300 T17818 T17819 arg1Of Newman-Keuls,post-test
R15975 T18719 T18718 arg1Of propionate,Fluticasone
R15976 T18719 T18720 arg1Of propionate,does
R15977 T18719 T18722 arg1Of propionate,affect
R15978 T18722 T18720 arg2Of affect,does
R15979 T18722 T18721 arg1Of affect,not
R15980 T18725 T18722 arg2Of export,affect
R15981 T18725 T18723 arg1Of export,GATA-3
R15982 T18725 T18724 arg1Of export,nuclear
R15983 T18727 T18726 arg2Of A,(
R15984 T18728 T18726 arg3Of ),(
R15985 T18731 T18726 arg1Of analysis,(
R15986 T18731 T18729 arg1Of analysis,Western
R15987 T18731 T18730 arg1Of analysis,blot
R15988 T18731 T18732 arg1Of analysis,showing
R15989 T18731 T18815 arg1Of analysis,(
R15990 T18731 T18818 arg1Of analysis,or
R15991 T18739 T18734 arg1Of B,the
R15992 T18739 T18735 arg1Of B,nuclear
R15993 T18739 T18736 arg1Of B,export
R15994 T18739 T18737 arg1Of B,inhibitor
R15995 T18739 T18738 arg1Of B,leptomycin
R15996 T18739 T18740 arg1Of B,(
R15997 T18739 T18744 arg1Of B,does
R15998 T18739 T18746 arg1Of B,affect
R15999 T18742 T18740 arg2Of nM,(
R16000 T18742 T18741 arg1Of nM,2
R16001 T18743 T18740 arg3Of ),(
R16002 T18746 T18744 arg2Of affect,does
R16003 T18746 T18745 arg1Of affect,not
R16004 T18746 T18772 arg1Of affect,","
R16005 T18748 T18746 arg2Of ability,affect
R16006 T18748 T18747 arg1Of ability,the
R16007 T18748 T18749 arg1Of ability,of
R16008 T18748 T18755 modOf ability,to
R16009 T18748 T18756 arg1Of ability,prevent
R16010 T18750 T18749 arg2Of FP,of
R16011 T18750 T18751 arg1Of FP,(
R16012 T18753 T18751 arg2Of M,(
R16013 T18753 T18752 arg1Of M,10−8
R16014 T18754 T18751 arg3Of ),(
R16015 T18756 T18755 arg1Of prevent,to
R16016 T18760 T18756 arg2Of localization,prevent
R16017 T18760 T18757 arg1Of localization,anti-CD3/CD28–stimulated
R16018 T18760 T18758 arg1Of localization,GATA-3
R16019 T18760 T18759 arg1Of localization,nuclear
R16020 T18760 T18761 arg2Of localization,measured
R16021 T18760 T18768 arg1Of localization,compared
R16022 T18761 T18762 arg1Of measured,at
R16023 T18765 T18766 arg1Of ***p,<
R16024 T18767 T18762 arg2Of 0.001,at
R16025 T18767 T18763 arg1Of 0.001,60
R16026 T18767 T18764 arg1Of 0.001,min.
R16027 T18767 T18765 arg1Of 0.001,***p
R16028 T18769 T18768 arg2Of to,compared
R16029 T18771 T18769 arg2Of cells,to
R16030 T18771 T18770 arg1Of cells,unstimulated
R16031 T18772 T18732 arg2Of ",",showing
R16032 T18772 T18733 arg1Of ",",that
R16033 T18777 T18778 arg1Of <,0.001
R16034 T18777 T18779 arg1Of <,compared
R16035 T18780 T18779 arg2Of to,compared
R16036 T18782 T18780 arg2Of cells.,to
R16037 T18782 T18781 arg1Of cells.,anti-CD3/CD28–stimulated
R16038 T18782 T18783 arg1Of cells.,(
R16039 T18784 T18783 arg2Of B,(
R16040 T18785 T18783 arg3Of ),(
R16041 T18788 T18773 arg1Of analysis,#
R16042 T18788 T18774 arg1Of analysis,#
R16043 T18788 T18775 arg1Of analysis,#
R16044 T18788 T18776 arg1Of analysis,p
R16045 T18788 T18777 arg1Of analysis,<
R16046 T18788 T18786 arg1Of analysis,Western
R16047 T18788 T18787 arg1Of analysis,blot
R16048 T18788 T18789 arg1Of analysis,showing
R16049 T18788 T18810 arg1Of analysis,is
R16050 T18788 T18811 arg2Of analysis,overexpressed
R16051 T18791 T18792 arg1Of FP,(
R16052 T18791 T18796 arg1Of FP,does
R16053 T18791 T18798 arg1Of FP,affect
R16054 T18794 T18792 arg2Of M,(
R16055 T18794 T18793 arg1Of M,10−8
R16056 T18795 T18792 arg3Of ),(
R16057 T18798 T18789 arg2Of affect,showing
R16058 T18798 T18790 arg1Of affect,that
R16059 T18798 T18796 arg2Of affect,does
R16060 T18798 T18797 arg1Of affect,not
R16061 T18798 T18802 arg1Of affect,over
R16062 T18801 T18798 arg2Of degradation,affect
R16063 T18801 T18799 arg1Of degradation,whole-cell
R16064 T18801 T18800 arg1Of degradation,GATA-3
R16065 T18806 T18805 arg2Of C,(
R16066 T18807 T18805 arg3Of ),(
R16067 T18808 T18804 arg1Of GFP-tagged,h.
R16068 T18808 T18805 arg1Of GFP-tagged,(
R16069 T18809 T18802 arg2Of GATA-3,over
R16070 T18809 T18803 arg1Of GATA-3,17
R16071 T18809 T18808 arg1Of GATA-3,GFP-tagged
R16072 T18811 T18810 arg2Of overexpressed,is
R16073 T18811 T18812 arg1Of overexpressed,and
R16074 T18812 T18772 arg2Of and,","
R16075 T18813 T18814 arg1Of cells,stimulated
R16076 T18814 T18812 arg2Of stimulated,and
R16077 T18816 T18815 arg2Of b–j,(
R16078 T18817 T18815 arg3Of ),(
R16079 T18818 T18819 arg1Of or,not
R16080 T18824 T18818 arg2Of anti-CD3/CD28,or
R16081 T18824 T18820 arg1Of anti-CD3/CD28,(
R16082 T18824 T18821 arg1Of anti-CD3/CD28,a
R16083 T18824 T18822 arg1Of anti-CD3/CD28,)
R16084 T18824 T18823 arg1Of anti-CD3/CD28,with
R16085 T18826 T18825 arg1Of effect,The
R16086 T18826 T18827 arg1Of effect,of
R16087 T18826 T18855 arg1Of effect,does
R16088 T18826 T18857 arg1Of effect,prevent
R16089 T18828 T18827 arg2Of treating,of
R16090 T18828 T18830 arg1Of treating,with
R16091 T18828 T18838 arg1Of treating,after
R16092 T18829 T18828 arg2Of cells,treating
R16093 T18831 T18830 arg2Of FP,with
R16094 T18831 T18832 arg1Of FP,(
R16095 T18834 T18832 arg2Of M,(
R16096 T18834 T18833 arg1Of M,10−8
R16097 T18834 T18835 arg1Of M,","
R16098 T18836 T18835 arg2Of f–j,","
R16099 T18837 T18832 arg3Of ),(
R16100 T18841 T18839 arg1Of stimulation,30
R16101 T18841 T18840 arg1Of stimulation,min
R16102 T18841 T18842 arg1Of stimulation,with
R16103 T18841 T18844 arg1Of stimulation,is
R16104 T18843 T18842 arg2Of anti-CD3/CD28,with
R16105 T18844 T18838 arg2Of is,after
R16106 T18844 T18845 arg1Of is,also
R16107 T18844 T18850 arg1Of is,FP
R16108 T18846 T18844 arg2Of shown.,is
R16109 T18846 T18847 arg1Of shown.,(
R16110 T18848 T18847 arg2Of D,(
R16111 T18849 T18847 arg3Of ),(
R16112 T18850 T18851 arg1Of FP,(
R16113 T18853 T18851 arg2Of M,(
R16114 T18853 T18852 arg1Of M,10−8
R16115 T18854 T18851 arg3Of ),(
R16116 T18857 T18855 arg2Of prevent,does
R16117 T18857 T18856 arg1Of prevent,not
R16118 T18857 T18862 arg1Of prevent,at
R16119 T18857 T18865 arg1Of prevent,after
R16120 T18857 T18870 arg1Of prevent,compared
R16121 T18861 T18857 arg2Of translocation,prevent
R16122 T18861 T18858 arg1Of translocation,anti-CD3/CD28–stimulated
R16123 T18861 T18859 arg1Of translocation,p65
R16124 T18861 T18860 arg1Of translocation,nuclear
R16125 T18864 T18862 arg2Of min,at
R16126 T18864 T18863 arg1Of min,60
R16127 T18867 T18868 arg1Of **p,<
R16128 T18869 T18865 arg2Of 0.01,after
R16129 T18869 T18866 arg1Of 0.01,stimulation.
R16130 T18869 T18867 arg1Of 0.01,**p
R16131 T18871 T18870 arg2Of to,compared
R16132 T18873 T18871 arg2Of cells,to
R16133 T18873 T18872 arg1Of cells,unstimulated
R16134 T18875 T18874 arg1Of results,All
R16135 T18875 T18876 arg1Of results,are
R16136 T18875 T18877 arg1Of results,representative
R16137 T18875 T18885 arg1Of results,are
R16138 T18875 T18886 arg2Of results,shown
R16139 T18876 T18884 arg1Of are,and
R16140 T18877 T18876 arg2Of representative,are
R16141 T18877 T18878 arg1Of representative,of
R16142 T18881 T18879 arg1Of four,at
R16143 T18881 T18880 arg1Of four,least
R16144 T18883 T18878 arg2Of experiments,of
R16145 T18883 T18881 arg1Of experiments,four
R16146 T18883 T18882 arg1Of experiments,independent
R16147 T18886 T18884 arg2Of shown,and
R16148 T18886 T18885 arg2Of shown,are
R16149 T18886 T18887 arg1Of shown,as
R16150 T18888 T18887 arg2Of mean±SEM,as
R16151 T18889 T18890 arg1Of Results,were
R16152 T18889 T18891 arg2Of Results,analysed
R16153 T18891 T18890 arg2Of analysed,were
R16154 T18893 T18891 arg1Of ANOVA,analysed
R16155 T18893 T18892 arg2Of ANOVA,by
R16156 T18893 T18894 arg2Of ANOVA,followed
R16157 T18897 T18894 arg1Of test,followed
R16158 T18897 T18895 arg2Of test,by
R16159 T18897 T18896 arg1Of test,Newman-Keuls
R16458 T19292 T19291 arg1Of propionate,Fluticasone
R16459 T19292 T19293 arg1Of propionate,impairs
R16460 T19293 T19303 arg1Of impairs,vivo
R16461 T19293 T19306 arg1Of impairs,vivo
R16462 T19295 T19293 arg2Of interaction,impairs
R16463 T19295 T19294 arg1Of interaction,GATA-3
R16464 T19295 T19296 arg1Of interaction,with
R16465 T19297 T19298 arg1Of importin-α,and
R16466 T19298 T19296 arg2Of and,with
R16467 T19301 T19298 arg2Of localization,and
R16468 T19301 T19299 arg1Of localization,GATA-3
R16469 T19301 T19300 arg1Of localization,nuclear
R16470 T19303 T19302 arg1Of vivo,in
R16471 T19303 T19304 arg1Of vivo,and
R16472 T19306 T19304 arg2Of vivo,and
R16473 T19306 T19305 arg1Of vivo,ex
R16474 T19308 T19309 arg1Of A,and
R16475 T19309 T19307 arg2Of and,(
R16476 T19309 T19325 modOf and,demonstrated
R16477 T19310 T19309 arg2Of B,and
R16478 T19311 T19307 arg3Of ),(
R16479 T19313 T19312 arg1Of analysis,Co-immunoprecipitation
R16480 T19313 T19314 arg1Of analysis,of
R16481 T19313 T19325 arg1Of analysis,demonstrated
R16482 T19315 T19314 arg2Of PBMCs,of
R16483 T19315 T19316 arg1Of PBMCs,from
R16484 T19319 T19316 arg2Of patients,from
R16485 T19319 T19317 arg1Of patients,steroid-naïve
R16486 T19319 T19318 arg1Of patients,asthma
R16487 T19319 T19320 arg2Of patients,treated
R16488 T19319 T19324 arg1Of patients,vitro
R16489 T19320 T19321 arg1Of treated,with
R16490 T19322 T19321 arg2Of FP,with
R16491 T19324 T19323 arg1Of vitro,in
R16492 T19327 T19325 arg2Of interaction,demonstrated
R16493 T19327 T19326 arg1Of interaction,impaired
R16494 T19327 T19328 arg1Of interaction,between
R16495 T19329 T19330 arg1Of GATA-3,and
R16496 T19330 T19328 arg2Of and,between
R16497 T19330 T19332 arg2Of and,measured
R16498 T19331 T19330 arg2Of importin-α,and
R16499 T19332 T19333 arg1Of measured,at
R16500 T19335 T19333 arg2Of min,at
R16501 T19335 T19334 arg1Of min,60
R16502 T19337 T19336 arg1Of bar,Each
R16503 T19337 T19338 arg1Of bar,represents
R16504 T19338 T19347 arg1Of represents,;
R16505 T19340 T19338 arg2Of mean±SEM,represents
R16506 T19340 T19339 arg1Of mean±SEM,the
R16507 T19340 T19341 arg1Of mean±SEM,of
R16508 T19344 T19342 arg1Of three,at
R16509 T19344 T19343 arg1Of three,least
R16510 T19346 T19341 arg2Of experiments,of
R16511 T19346 T19344 arg1Of experiments,three
R16512 T19346 T19345 arg1Of experiments,independent
R16513 T19349 T19348 arg1Of p,***
R16514 T19349 T19351 arg1Of p,0.001
R16515 T19349 T19352 arg1Of p,compared
R16516 T19351 T19350 arg1Of 0.001,<
R16517 T19352 T19347 arg2Of compared,;
R16518 T19352 T19353 arg1Of compared,with
R16519 T19352 T19355 arg1Of compared,as
R16520 T19354 T19353 arg2Of control,with
R16521 T19356 T19355 arg2Of determined,as
R16522 T19356 T19357 arg1Of determined,by
R16523 T19359 T19357 arg2Of analysis.,by
R16524 T19359 T19358 arg1Of analysis.,ANOVA/Newman-Keuls
R16525 T19359 T19360 arg1Of analysis.,(
R16526 T19361 T19362 arg1Of C,and
R16527 T19362 T19360 arg2Of and,(
R16528 T19363 T19362 arg2Of D,and
R16529 T19364 T19360 arg3Of ),(
R16530 T19366 T19365 arg1Of analyses,Co-immunoprecipitation
R16531 T19366 T19367 arg1Of analyses,of
R16532 T19366 T19386 arg1Of analyses,demonstrated
R16533 T19368 T19367 arg2Of PBMCs,of
R16534 T19368 T19369 arg1Of PBMCs,from
R16535 T19372 T19369 arg2Of patients,from
R16536 T19372 T19370 arg1Of patients,steroid-naïve
R16537 T19372 T19371 arg1Of patients,asthma
R16538 T19372 T19373 arg2Of patients,treated
R16539 T19373 T19374 arg1Of treated,with
R16540 T19376 T19374 arg2Of FP,with
R16541 T19376 T19375 arg2Of FP,inhaled
R16542 T19376 T19377 arg1Of FP,(
R16543 T19376 T19385 arg1Of FP,vivo
R16544 T19379 T19377 arg2Of µg,(
R16545 T19379 T19378 arg1Of µg,500
R16546 T19379 T19380 arg1Of µg,via
R16547 T19382 T19380 arg2Of spacer,via
R16548 T19382 T19381 arg1Of spacer,a
R16549 T19383 T19377 arg3Of ),(
R16550 T19385 T19384 arg1Of vivo,in
R16551 T19386 T19347 arg3Of demonstrated,;
R16552 T19388 T19386 arg2Of association,demonstrated
R16553 T19388 T19387 arg2Of association,decreased
R16554 T19388 T19389 arg1Of association,between
R16555 T19390 T19391 arg1Of GATA-3,and
R16556 T19391 T19389 arg2Of and,between
R16557 T19392 T19391 arg2Of importin-α,and
R16558 T19395 T19393 arg1Of values,The
R16559 T19395 T19394 arg1Of values,individual
R16560 T19395 T19396 arg1Of values,for
R16561 T19395 T19399 arg1Of values,are
R16562 T19395 T19400 arg2Of values,presented
R16563 T19398 T19396 arg2Of treatment,for
R16564 T19398 T19397 arg1Of treatment,each
R16565 T19400 T19399 arg2Of presented,are
R16566 T19403 T19402 arg2Of E,(
R16567 T19404 T19402 arg3Of ),(
R16568 T19407 T19400 arg3Of blot,presented
R16569 T19407 T19401 arg1Of blot,graphically.
R16570 T19407 T19402 arg1Of blot,(
R16571 T19407 T19405 arg1Of blot,Representative
R16572 T19407 T19406 arg1Of blot,Western
R16573 T19407 T19408 arg1Of blot,showing
R16574 T19411 T19410 arg1Of expression,importin-α
R16575 T19411 T19412 arg1Of expression,was
R16576 T19411 T19413 arg2Of expression,unaffected
R16577 T19413 T19408 arg2Of unaffected,showing
R16578 T19413 T19409 arg1Of unaffected,that
R16579 T19413 T19412 arg2Of unaffected,was
R16580 T19415 T19413 arg1Of inhalation,unaffected
R16581 T19415 T19414 arg2Of inhalation,by
R16582 T19415 T19416 arg1Of inhalation,of
R16583 T19417 T19416 arg2Of FP,of
R16584 T19418 T19419 arg1Of Blot,is
R16585 T19418 T19420 arg1Of Blot,representative
R16586 T19420 T19419 arg2Of representative,is
R16587 T19420 T19421 arg1Of representative,of
R16588 T19422 T19421 arg2Of gels,of
R16589 T19422 T19423 arg1Of gels,from
R16590 T19425 T19423 arg2Of participants,from
R16591 T19425 T19424 arg1Of participants,three
R16836 T19734 T19732 arg2Of propionate,Inhaled
R16837 T19734 T19733 arg1Of propionate,fluticasone
R16838 T19734 T19735 arg1Of propionate,impairs
R16839 T19738 T19735 arg2Of localization,impairs
R16840 T19738 T19736 arg1Of localization,GATA-3
R16841 T19738 T19737 arg1Of localization,nuclear
R16842 T19738 T19739 arg1Of localization,in
R16843 T19740 T19739 arg2Of PBMCs,in
R16844 T19742 T19741 arg2Of A,(
R16845 T19743 T19741 arg3Of ),(
R16846 T19745 T19741 arg1Of immunocytochemistry,(
R16847 T19745 T19744 arg1Of immunocytochemistry,Representative
R16848 T19745 T19746 arg1Of immunocytochemistry,of
R16849 T19747 T19746 arg2Of showing,of
R16850 T19747 T19778 arg1Of showing,following
R16851 T19749 T19747 arg2Of effect,showing
R16852 T19749 T19748 arg1Of effect,the
R16853 T19749 T19750 arg1Of effect,of
R16854 T19749 T19757 arg1Of effect,on
R16855 T19752 T19750 arg2Of FP,of
R16856 T19752 T19751 arg2Of FP,inhaled
R16857 T19752 T19753 arg1Of FP,(
R16858 T19755 T19753 arg2Of µg,(
R16859 T19755 T19754 arg1Of µg,500
R16860 T19756 T19753 arg3Of ),(
R16861 T19758 T19759 arg1Of GR,and
R16862 T19760 T19759 arg2Of GATA-3,and
R16863 T19764 T19763 arg2Of B,(
R16864 T19765 T19763 arg3Of ),(
R16865 T19768 T19757 arg2Of immunoreactivity,on
R16866 T19768 T19758 arg1Of immunoreactivity,GR
R16867 T19768 T19760 arg1Of immunoreactivity,GATA-3
R16868 T19768 T19761 arg1Of immunoreactivity,nuclear
R16869 T19768 T19762 arg1Of immunoreactivity,localisation.
R16870 T19768 T19763 arg1Of immunoreactivity,(
R16871 T19768 T19766 arg1Of immunoreactivity,Nuclear
R16872 T19768 T19767 arg1Of immunoreactivity,GATA-3
R16873 T19768 T19769 arg1Of immunoreactivity,in
R16874 T19768 T19771 arg1Of immunoreactivity,from
R16875 T19770 T19769 arg2Of PBMCs,in
R16876 T19775 T19771 arg2Of patients,from
R16877 T19775 T19772 arg1Of patients,seven
R16878 T19775 T19773 arg1Of patients,steroid-naïve
R16879 T19775 T19774 arg1Of patients,asthma
R16880 T19777 T19776 arg1Of h,2
R16881 T19778 T19777 arg1Of following,h
R16882 T19781 T19778 arg2Of treatment,following
R16883 T19781 T19779 arg2Of treatment,inhaled
R16884 T19781 T19780 arg1Of treatment,FP
R16885 T19781 T19782 arg1Of treatment,(
R16886 T19783 T19784 arg1Of 100,or
R16887 T19785 T19784 arg2Of 500,or
R16888 T19786 T19782 arg2Of µg,(
R16889 T19786 T19783 arg1Of µg,100
R16890 T19786 T19785 arg1Of µg,500
R16891 T19786 T19787 arg1Of µg,via
R16892 T19788 T19787 arg2Of spacer,via
R16893 T19789 T19782 arg3Of ),(
R16894 T19791 T19792 arg1Of median,and
R16895 T19793 T19792 arg2Of interquartile,and
R16896 T19794 T19790 arg1Of ranges,The
R16897 T19794 T19791 arg1Of ranges,median
R16898 T19794 T19793 arg1Of ranges,interquartile
R16899 T19794 T19795 arg1Of ranges,for
R16900 T19794 T19798 arg1Of ranges,are
R16901 T19794 T19799 arg2Of ranges,presented
R16902 T19797 T19795 arg2Of treatment,for
R16903 T19797 T19796 arg1Of treatment,each
R16904 T19799 T19798 arg2Of presented,are
R16905 T19799 T19800 arg1Of presented,as
R16906 T19799 T19807 arg1Of presented,;
R16907 T19803 T19800 arg2Of plot,as
R16908 T19803 T19801 arg1Of plot,a
R16909 T19803 T19802 arg1Of plot,box-and-whiskers
R16910 T19803 T19804 arg1Of plot,(
R16911 T19805 T19804 arg2Of n = 7,(
R16912 T19806 T19804 arg3Of ),(
R16913 T19811 T19810 arg1Of 0.05,<
R16914 T19812 T19808 arg1Of Wilcoxon,*
R16915 T19812 T19809 arg1Of Wilcoxon,p
R16916 T19812 T19811 arg1Of Wilcoxon,0.05
R16917 T19812 T19813 arg2Of Wilcoxon,'s
R16918 T19815 T19813 arg1Of test,'s
R16919 T19815 T19814 arg1Of test,rank
R16920 T19815 T19816 arg1Of test,compared
R16921 T19815 T19826 arg1Of test,demonstrated
R16922 T19817 T19816 arg2Of with,compared
R16923 T19820 T19819 arg2Of C,(
R16924 T19821 T19819 arg3Of ),(
R16925 T19823 T19817 arg2Of analyses,with
R16926 T19823 T19818 arg1Of analyses,placebo.
R16927 T19823 T19819 arg1Of analyses,(
R16928 T19823 T19822 arg1Of analyses,Immunoblotting
R16929 T19823 T19824 arg1Of analyses,of
R16930 T19825 T19824 arg2Of PBMCs,of
R16931 T19826 T19836 arg1Of demonstrated,and
R16932 T19829 T19826 arg2Of decrease,demonstrated
R16933 T19829 T19827 arg1Of decrease,a
R16934 T19829 T19828 arg1Of decrease,time-dependent
R16935 T19829 T19830 arg1Of decrease,in
R16936 T19832 T19830 arg2Of expression,in
R16937 T19832 T19831 arg1Of expression,nuclear
R16938 T19832 T19833 arg1Of expression,of
R16939 T19834 T19833 arg2Of GATA-3,of
R16940 T19836 T19807 arg2Of and,;
R16941 T19836 T19835 arg1Of and,","
R16942 T19840 T19837 arg2Of expression,increased
R16943 T19840 T19838 arg1Of expression,cytoplasmic
R16944 T19840 T19839 arg1Of expression,GATA-3
R16945 T19840 T19841 arg1Of expression,after
R16946 T19840 T19852 arg1Of expression,demonstrated
R16947 T19840 T19863 arg1Of expression,increased
R16948 T19842 T19841 arg2Of inhalation,after
R16949 T19842 T19843 arg1Of inhalation,of
R16950 T19846 T19845 arg2Of D,(
R16951 T19847 T19845 arg3Of ),(
R16952 T19849 T19843 arg2Of analyses,of
R16953 T19849 T19844 arg1Of analyses,FP.
R16954 T19849 T19845 arg1Of analyses,(
R16955 T19849 T19848 arg1Of analyses,Immunoblotting
R16956 T19849 T19850 arg1Of analyses,of
R16957 T19851 T19850 arg2Of PBMCs,of
R16958 T19852 T19862 arg1Of demonstrated,and
R16959 T19855 T19852 arg2Of decrease,demonstrated
R16960 T19855 T19853 arg1Of decrease,a
R16961 T19855 T19854 arg1Of decrease,dose-dependent
R16962 T19855 T19856 arg1Of decrease,in
R16963 T19858 T19856 arg2Of expression,in
R16964 T19858 T19857 arg1Of expression,nuclear
R16965 T19858 T19859 arg1Of expression,of
R16966 T19860 T19859 arg2Of GATA-3,of
R16967 T19862 T19836 arg2Of and,and
R16968 T19862 T19861 arg1Of and,","
R16969 T19863 T19862 arg2Of increased,and
R16970 T19863 T19869 arg1Of increased,after
R16971 T19866 T19863 arg2Of expression,increased
R16972 T19866 T19864 arg1Of expression,cytoplasmic
R16973 T19866 T19865 arg1Of expression,GATA-3
R16974 T19868 T19867 arg1Of h,2
R16975 T19869 T19868 arg1Of after,h
R16976 T19870 T19869 arg2Of inhalation,after
R16977 T19870 T19871 arg1Of inhalation,of
R16978 T19872 T19871 arg2Of FP,of
R16979 T19874 T19873 arg1Of H1,Histone
R16980 T19874 T19875 arg1Of H1,and
R16981 T19875 T19878 arg1Of and,confirmed
R16982 T19877 T19875 arg2Of immunoblotting,and
R16983 T19877 T19876 arg1Of immunoblotting,MEK-1
R16984 T19881 T19878 arg2Of protein,confirmed
R16985 T19881 T19879 arg1Of protein,equivalent
R16986 T19881 T19880 arg1Of protein,total
R16987 T19881 T19882 arg1Of protein,loading
R16988 T19882 T19883 arg1Of loading,for
R16989 T19882 T19889 arg1Of loading,respectively
R16990 T19885 T19886 arg1Of nuclear,and
R16991 T19887 T19886 arg2Of cytoplasmic,and
R16992 T19888 T19883 arg2Of fractions,for
R16993 T19888 T19884 arg1Of fractions,the
R16994 T19888 T19885 arg1Of fractions,nuclear
R16995 T19888 T19887 arg1Of fractions,cytoplasmic
R16996 T19890 T19891 arg1Of Quantification,of
R16997 T19890 T19903 arg1Of Quantification,is
R16998 T19890 T19904 arg2Of Quantification,shown
R16999 T19894 T19891 arg2Of data,of
R17000 T19894 T19892 arg1Of data,the
R17001 T19894 T19893 arg1Of data,densitometry
R17002 T19894 T19895 arg1Of data,in
R17003 T19897 T19896 arg2Of C,(
R17004 T19897 T19899 arg1Of C,and
R17005 T19898 T19896 arg3Of ),(
R17006 T19899 T19895 arg2Of and,in
R17007 T19901 T19899 arg2Of D,and
R17008 T19901 T19900 arg2Of D,(
R17009 T19902 T19900 arg3Of ),(
R17010 T19904 T19903 arg2Of shown,is
R17011 T19904 T19905 arg1Of shown,as
R17012 T19908 T19905 arg2Of plot,as
R17013 T19908 T19906 arg1Of plot,a
R17014 T19908 T19907 arg1Of plot,box-and-whiskers
R17015 T19908 T19909 arg1Of plot,of
R17016 T19910 T19909 arg2Of results,of
R17017 T19910 T19911 arg1Of results,from
R17018 T19910 T19914 arg2Of results,for
R17019 T19910 T19915 arg1Of results,which
R17020 T19913 T19911 arg2Of participants,from
R17021 T19913 T19912 arg1Of participants,n = 6
R17022 T19916 T19917 arg1Of data,were
R17023 T19917 T19914 arg1Of were,for
R17024 T19919 T19920 arg1Of *p,<
R17025 T19921 T19917 arg2Of 0.05,were
R17026 T19921 T19918 arg1Of 0.05,available.
R17027 T19921 T19919 arg1Of 0.05,*p
R17028 T19921 T19922 arg2Of 0.05,compared
R17029 T19921 T19933 modOf 0.05,demonstrated
R17030 T19921 T19945 arg1Of 0.05,of
R17031 T19924 T19922 arg3Of control.,compared
R17032 T19924 T19923 arg1Of control.,to
R17033 T19924 T19925 arg1Of control.,(
R17034 T19926 T19925 arg2Of E,(
R17035 T19927 T19925 arg3Of ),(
R17036 T19930 T19928 arg1Of analyses,Western
R17037 T19930 T19929 arg1Of analyses,blot
R17038 T19930 T19931 arg1Of analyses,of
R17039 T19930 T19933 arg1Of analyses,demonstrated
R17040 T19932 T19931 arg2Of PBMCs,of
R17041 T19936 T19933 arg2Of decrease,demonstrated
R17042 T19936 T19934 arg1Of decrease,a
R17043 T19936 T19935 arg1Of decrease,time-dependent
R17044 T19936 T19937 arg1Of decrease,in
R17045 T19939 T19937 arg2Of phosphorylation,in
R17046 T19939 T19938 arg1Of phosphorylation,dual
R17047 T19939 T19940 arg1Of phosphorylation,(
R17048 T19941 T19942 arg1Of threonine-180,and
R17049 T19942 T19940 arg2Of and,(
R17050 T19943 T19942 arg2Of tyrosine-182,and
R17051 T19944 T19940 arg3Of ),(
R17052 T19947 T19945 arg2Of MAPK,of
R17053 T19947 T19946 arg1Of MAPK,p38
R17054 T19947 T19948 arg1Of MAPK,after
R17055 T19949 T19948 arg2Of inhalation,after
R17056 T19949 T19950 arg1Of inhalation,of
R17057 T19951 T19950 arg2Of FP,of
R17058 T19951 T19952 arg1Of FP,(
R17059 T19954 T19952 arg2Of µg,(
R17060 T19954 T19953 arg1Of µg,500
R17061 T19955 T19952 arg3Of ),(
R17062 T19957 T19956 arg1Of results,The
R17063 T19957 T19958 arg2Of results,shown
R17064 T19957 T19963 arg1Of results,are
R17065 T19957 T19964 arg1Of results,representative
R17066 T19958 T19959 arg1Of shown,in
R17067 T19961 T19959 arg2Of E,in
R17068 T19961 T19960 arg2Of E,(
R17069 T19962 T19960 arg3Of ),(
R17070 T19964 T19963 arg2Of representative,are
R17071 T19964 T19965 arg1Of representative,of
R17072 T19966 T19965 arg2Of samples,of
R17073 T19966 T19967 arg1Of samples,from
R17074 T19969 T19967 arg2Of participants,from
R17075 T19969 T19968 arg1Of participants,two
R3974 T4628 T4629 modOf extracted,using
R3976 T4631 T4629 arg2Of buffer,using
R3977 T4631 T4630 arg1Of buffer,lysis
R3978 T4631 T4632 arg1Of buffer,(
R6569 T7646 T7650 arg1Of values,were
R6570 T7646 T7651 arg2Of values,subtracted
R6571 T7646 T7653 arg1Of values,normalize
R6573 T7649 T7648 arg1Of lane,each
R6574 T7651 T7650 arg2Of subtracted,were
R6575 T7653 T7651 arg3Of normalize,subtracted
R6576 T7653 T7652 arg1Of normalize,to
R6577 T7655 T7653 arg2Of measurement,normalize
R6578 T7655 T7654 arg1Of measurement,each
R6579 T7657 T7656 arg1Of bands,The
R6580 T7657 T7658 arg1Of bands,were
R6581 T7657 T7659 arg2Of bands,quantified
R6582 T7659 T7658 arg2Of quantified,were
R6583 T7660 T7659 arg3Of using,quantified
R6584 T7663 T7660 arg2Of software,using
R6585 T7663 T7661 arg1Of software,the
R6586 T7663 T7662 arg1Of software,Gelworks
R6587 T7666 T7664 arg1Of blots,All
R6588 T7666 T7665 arg1Of blots,Western
R6589 T7666 T7667 arg1Of blots,were
R6590 T7666 T7668 arg2Of blots,exposed
R6591 T7668 T7667 arg2Of exposed,were
R6592 T7668 T7669 modOf exposed,to
R6593 T7668 T7677 arg1Of exposed,and
R6594 T7670 T7669 arg1Of film,to
R6595 T7670 T7671 arg1Of film,for
R6596 T7673 T7671 arg2Of lengths,for
R6597 T7673 T7672 arg1Of lengths,varying
R6598 T7673 T7674 arg1Of lengths,of
R6599 T7675 T7674 arg2Of time,of
R6600 T7677 T7676 arg1Of and,","
R6601 T7679 T7678 arg1Of films,only
R6602 T7679 T7680 arg1Of films,generating
R6603 T7679 T7685 arg1Of films,were

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T14221 40550-40554 Anaphor denotes that
T14222 40524-40539 Antecedent denotes phosphorylation
T14223 41035-41046 Anaphor denotes these genes
T14224 40939-40943 Antecedent denotes IL-4
T14225 40944-40948 Antecedent denotes IL-5
T426 527-540 Anaphor denotes the cytokines
T427 541-559 Antecedent denotes interleukin (IL)-4
T428 561-565 Antecedent denotes IL-5
T429 571-576 Antecedent denotes IL-13
T2213 7643-7648 Anaphor denotes which
T2214 7635-7641 Antecedent denotes GATA-3
T2215 8499-8501 Anaphor denotes it
T2216 8463-8469 Antecedent denotes GATA-3
T2217 8565-8568 Anaphor denotes its
T2218 9346-9349 Anaphor denotes its
T2219 9328-9334 Antecedent denotes GATA-3
T2220 9695-9700 Anaphor denotes which
T2221 9663-9687 Antecedent denotes glucocorticoid receptors
T2222 9739-9743 Anaphor denotes they
T2223 9695-9700 Antecedent denotes which
R12318 T14221 T14222 boundBy that,phosphorylation
R12319 T14223 T14224 boundBy these genes,IL-4
R12320 T14223 T14225 boundBy these genes,IL-5
R768 T426 T427 boundBy the cytokines,interleukin (IL)-4
R777 T426 T428 boundBy the cytokines,IL-5
R778 T426 T429 boundBy the cytokines,IL-13
R1958 T2213 T2214 boundBy which,GATA-3
R1960 T2215 T2216 boundBy it,GATA-3
R1961 T2217 T2216 boundBy its,GATA-3
R1963 T2218 T2219 boundBy its,GATA-3
R1965 T2220 T2221 boundBy which,glucocorticoid receptors
R1966 T2222 T2220 boundBy they,which

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T477 495-497 IN denotes in
T478 498-508 VBG denotes regulating
T479 509-512 DT denotes the
T480 513-523 NN denotes expression
T481 524-526 IN denotes of
T482 527-530 DT denotes the
T483 531-540 NNS denotes cytokines
T484 541-552 VBP denotes interleukin
T485 553-554 -LRB- denotes (
T486 554-556 NNP denotes IL
T487 556-557 -RRB- denotes )
T488 557-559 CD denotes -4
T489 559-560 , denotes ,
T490 561-565 NN denotes IL-5
T491 565-566 , denotes ,
T492 567-570 CC denotes and
T493 571-576 NN denotes IL-13
T494 577-581 IN denotes from
T495 582-583 NNP denotes T
T496 584-592 JJ denotes helper-2
T497 593-594 -LRB- denotes (
T498 594-597 JJ denotes Th2
T499 597-598 -RRB- denotes )
T500 599-604 NNS denotes cells
T501 605-608 CC denotes and
T502 609-618 RB denotes therefore
T503 619-621 VBZ denotes is
T504 622-623 DT denotes a
T505 624-627 JJ denotes key
T506 628-636 NN denotes mediator
T507 637-639 IN denotes of
T508 640-648 JJ denotes allergic
T509 649-657 NNS denotes diseases
T510 657-658 . denotes .
T511 659-674 NNS denotes Corticosteroids
T512 675-678 VBP denotes are
T513 679-685 RB denotes highly
T514 686-695 JJ denotes effective
T515 696-698 IN denotes in
T516 699-710 VBG denotes suppressing
T517 711-719 JJ denotes allergic
T518 720-732 NN denotes inflammation
T519 732-733 , denotes ,
T520 734-737 CC denotes but
T521 738-743 PRP$ denotes their
T522 744-751 NNS denotes effects
T523 752-754 IN denotes on
T524 755-761 NN denotes GATA-3
T525 762-765 VBP denotes are
T526 766-773 JJ denotes unknown
T527 773-774 . denotes .
T528 775-777 PRP denotes We
T529 778-790 VBD denotes investigated
T530 791-794 DT denotes the
T531 795-801 NN denotes effect
T532 802-804 IN denotes of
T533 805-808 DT denotes the
T534 809-823 JJ denotes corticosteroid
T535 824-835 NN denotes fluticasone
T536 836-846 NN denotes propionate
T537 847-849 IN denotes on
T538 850-856 JJ denotes GATA-3
T539 857-867 NN denotes regulation
T540 868-870 IN denotes in
T541 871-876 JJ denotes human
T542 877-890 NNS denotes T-lymphocytes
T543 891-893 IN denotes in
T544 894-899 NN denotes vitro
T545 900-903 CC denotes and
T546 904-906 IN denotes in
T547 907-911 NN denotes vivo
T548 911-912 . denotes .
T549 914-921 NNS denotes Methods
T550 922-925 CC denotes and
T551 926-934 NNS denotes Findings
T552 935-937 IN denotes In
T553 938-939 DT denotes a
T554 940-941 NNP denotes T
T555 942-952 NN denotes lymphocyte
T556 953-957 NN denotes cell
T557 958-962 NN denotes line
T558 963-964 -LRB- denotes (
T559 964-970 JJ denotes HuT-78
T560 970-971 -RRB- denotes )
T561 972-975 CC denotes and
T562 976-986 JJ denotes peripheral
T563 987-992 NN denotes blood
T564 993-1004 NN denotes mononuclear
T565 1005-1010 NNS denotes cells
T566 1011-1021 VBN denotes stimulated
T567 1022-1024 IN denotes by
T568 1025-1033 JJ denotes anti-CD3
T569 1034-1037 CC denotes and
T570 1038-1047 JJ denotes anti-CD28
T571 1048-1050 IN denotes in
T572 1051-1056 NN denotes vitro
T573 1057-1059 PRP denotes we
T574 1060-1072 VBD denotes demonstrated
T575 1073-1077 IN denotes that
T576 1078-1089 NN denotes fluticasone
T577 1090-1098 NNS denotes inhibits
T578 1099-1106 JJ denotes nuclear
T579 1107-1120 NN denotes translocation
T580 1121-1123 IN denotes of
T581 1124-1130 NNP denotes GATA-3
T582 1131-1134 CC denotes and
T583 1135-1145 NN denotes expression
T584 1146-1148 IN denotes of
T585 1149-1152 JJ denotes Th2
T586 1153-1162 NNS denotes cytokines
T587 1163-1166 IN denotes via
T588 1167-1168 DT denotes a
T589 1169-1178 NN denotes mechanism
T590 1179-1190 JJ denotes independent
T591 1191-1193 IN denotes of
T592 1194-1201 JJ denotes nuclear
T593 1202-1211 NN denotes factor-κB
T594 1212-1215 CC denotes and
T595 1216-1218 VBZ denotes is
T596 1219-1222 JJ denotes due
T597 1222-1223 , denotes ,
T598 1224-1226 IN denotes in
T599 1227-1231 NN denotes part
T600 1231-1232 , denotes ,
T601 1233-1235 TO denotes to
T602 1236-1247 NN denotes competition
T603 1248-1255 IN denotes between
T604 1256-1262 NNP denotes GATA-3
T605 1263-1266 CC denotes and
T606 1267-1270 DT denotes the
T607 1271-1287 JJ denotes ligand-activated
T608 1288-1302 NN denotes glucocorticoid
T609 1303-1311 NN denotes receptor
T610 1312-1315 IN denotes for
T611 1316-1323 JJ denotes nuclear
T612 1324-1333 NN denotes transport
T613 1334-1341 IN denotes through
T614 1342-1345 DT denotes the
T615 1346-1353 JJ denotes nuclear
T616 1354-1362 NN denotes importer
T617 1363-1373 NN denotes importin-α
T618 1373-1374 . denotes .
T619 1375-1377 IN denotes In
T620 1378-1386 NN denotes addition
T621 1386-1387 , denotes ,
T622 1388-1399 NN denotes fluticasone
T623 1400-1407 VBZ denotes induces
T624 1408-1411 DT denotes the
T625 1412-1422 NN denotes expression
T626 1423-1425 IN denotes of
T627 1426-1443 JJ denotes mitogen-activated
T628 1444-1451 NN denotes protein
T629 1452-1458 NN denotes kinase
T630 1459-1460 -LRB- denotes (
T631 1460-1464 NNP denotes MAPK
T632 1464-1465 -RRB- denotes )
T633 1466-1479 JJ denotes phosphatase-1
T634 1480-1481 -LRB- denotes (
T635 1481-1486 NNP denotes MKP-1
T636 1486-1487 -RRB- denotes )
T637 1487-1488 , denotes ,
T638 1489-1492 DT denotes the
T639 1493-1503 JJ denotes endogenous
T640 1504-1513 NN denotes inhibitor
T641 1514-1516 IN denotes of
T642 1517-1520 CD denotes p38
T643 1521-1525 NNP denotes MAPK
T644 1525-1526 , denotes ,
T645 1527-1532 WDT denotes which
T646 1533-1535 VBZ denotes is
T647 1536-1545 JJ denotes necessary
T648 1546-1549 IN denotes for
T649 1550-1556 JJ denotes GATA-3
T650 1557-1564 JJ denotes nuclear
T651 1565-1578 NN denotes translocation
T652 1578-1579 . denotes .
T653 1580-1585 DT denotes These
T654 1586-1596 JJ denotes inhibitory
T655 1597-1604 NNS denotes effects
T656 1605-1607 IN denotes of
T657 1608-1619 NN denotes fluticasone
T658 1620-1623 VBP denotes are
T659 1624-1629 JJ denotes rapid
T660 1629-1630 , denotes ,
T661 1631-1637 JJ denotes potent
T662 1637-1638 , denotes ,
T663 1639-1642 CC denotes and
T664 1643-1652 VBN denotes prolonged
T665 1652-1653 . denotes .
T666 1654-1656 PRP denotes We
T667 1657-1661 RB denotes also
T668 1662-1674 VBD denotes demonstrated
T669 1675-1679 IN denotes that
T670 1680-1687 JJ denotes inhaled
T671 1688-1699 NN denotes fluticasone
T672 1700-1708 VBZ denotes inhibits
T673 1709-1715 JJ denotes GATA-3
T674 1716-1723 JJ denotes nuclear
T675 1724-1737 NN denotes translocation
T676 1738-1740 IN denotes in
T677 1741-1751 JJ denotes peripheral
T678 1752-1757 NN denotes blood
T679 1758-1769 NNS denotes lymphocytes
T680 1770-1772 IN denotes of
T681 1773-1781 NNS denotes patients
T682 1782-1786 IN denotes with
T683 1787-1793 NN denotes asthma
T684 1794-1796 IN denotes in
T685 1797-1801 NN denotes vivo
T686 1801-1802 . denotes .
T687 1804-1815 NNS denotes Conclusions
T688 1816-1831 NNS denotes Corticosteroids
T689 1832-1836 VBP denotes have
T690 1837-1838 DT denotes a
T691 1839-1845 JJ denotes potent
T692 1846-1856 JJ denotes inhibitory
T693 1857-1863 NN denotes effect
T694 1864-1866 IN denotes on
T695 1867-1873 JJ denotes GATA-3
T696 1874-1877 IN denotes via
T697 1878-1881 CD denotes two
T698 1882-1893 VBG denotes interacting
T699 1894-1904 NNS denotes mechanisms
T700 1905-1909 WDT denotes that
T701 1910-1918 RB denotes potently
T702 1919-1927 VBP denotes suppress
T703 1928-1931 JJ denotes Th2
T704 1932-1940 NN denotes cytokine
T705 1941-1951 NN denotes expression
T706 1951-1952 . denotes .
T707 1953-1957 DT denotes This
T708 1958-1963 NN denotes novel
T709 1964-1973 NN denotes mechanism
T710 1974-1976 IN denotes of
T711 1977-1983 NN denotes action
T712 1984-1986 IN denotes of
T713 1987-2002 NNS denotes corticosteroids
T714 2003-2006 MD denotes may
T715 2007-2014 VB denotes account
T716 2015-2018 IN denotes for
T717 2019-2022 DT denotes the
T718 2023-2031 JJ denotes striking
T719 2032-2040 JJ denotes clinical
T720 2041-2049 NN denotes efficacy
T721 2050-2052 IN denotes of
T722 2053-2068 NNS denotes corticosteroids
T723 2069-2071 IN denotes in
T724 2072-2075 DT denotes the
T725 2076-2085 NN denotes treatment
T726 2086-2088 IN denotes of
T727 2089-2097 JJ denotes allergic
T728 2098-2106 NNS denotes diseases
T729 2106-2107 . denotes .
T730 2109-2115 VB denotes Please
T731 2116-2119 VB denotes see
T732 2120-2125 RB denotes later
T733 2126-2128 IN denotes in
T734 2129-2132 DT denotes the
T735 2133-2140 NN denotes article
T736 2141-2144 IN denotes for
T737 2145-2152 NNS denotes Editors
T738 2152-2153 POS denotes '
T739 2154-2161 NN denotes Summary
T2279 7246-7258 NNP denotes Inflammation
T2280 7259-7261 IN denotes in
T2281 7262-7270 JJ denotes allergic
T2282 7271-7279 NNS denotes diseases
T2283 7280-7284 JJ denotes such
T2284 7285-7287 IN denotes as
T2285 7288-7294 NN denotes asthma
T2286 7294-7295 , denotes ,
T2287 7296-7304 NN denotes rhinitis
T2288 7304-7305 , denotes ,
T2289 7306-7309 CC denotes and
T2290 7310-7316 JJ denotes atopic
T2291 7317-7327 NN denotes dermatitis
T2292 7328-7330 VBZ denotes is
T2293 7331-7339 VBN denotes mediated
T2294 7340-7343 IN denotes via
T2295 7344-7354 NN denotes expression
T2296 7355-7357 IN denotes of
T2297 7358-7361 DT denotes the
T2298 7362-7371 NNS denotes cytokines
T2299 7372-7383 VBP denotes interleukin
T2300 7384-7385 -LRB- denotes (
T2301 7385-7387 NNP denotes IL
T2302 7387-7388 -RRB- denotes )
T2303 7388-7390 CD denotes -4
T2304 7390-7391 , denotes ,
T2305 7392-7396 NN denotes IL-5
T2306 7396-7397 , denotes ,
T2307 7398-7401 CC denotes and
T2308 7402-7407 NN denotes IL-13
T2309 7408-7412 IN denotes from
T2310 7413-7414 NNP denotes T
T2311 7415-7423 JJ denotes helper-2
T2312 7424-7425 -LRB- denotes (
T2313 7425-7428 JJ denotes Th2
T2314 7428-7429 -RRB- denotes )
T2315 7430-7435 NNS denotes cells
T2316 7435-7436 . denotes .
T2317 7437-7441 NN denotes IL-4
T2318 7442-7445 CC denotes and
T2319 7446-7451 JJ denotes IL-13
T2320 7452-7460 VB denotes regulate
T2321 7461-7464 DT denotes the
T2322 7465-7475 NN denotes expression
T2323 7476-7478 IN denotes of
T2324 7479-7482 NNP denotes IgE
T2325 7483-7487 IN denotes from
T2326 7488-7489 NNP denotes B
T2327 7490-7501 NNS denotes lymphocytes
T2328 7501-7502 , denotes ,
T2329 7503-7510 IN denotes whereas
T2330 7511-7515 NNP denotes IL-5
T2331 7516-7521 VBZ denotes plays
T2332 7522-7523 DT denotes a
T2333 7524-7527 JJ denotes key
T2334 7528-7532 NN denotes role
T2335 7533-7535 IN denotes in
T2336 7536-7548 JJ denotes eosinophilic
T2337 7549-7561 NN denotes inflammation
T2338 7562-7563 NNP denotes [
T2339 7563-7564 CD denotes 1
T2340 7564-7565 NNP denotes ]
T2341 7565-7566 . denotes .
T2342 7567-7570 CD denotes Th2
T2343 7571-7580 NNS denotes cytokines
T2344 7581-7584 VBP denotes are
T2345 7585-7594 VBN denotes regulated
T2346 7595-7597 IN denotes by
T2347 7598-7601 DT denotes the
T2348 7602-7606 NN denotes zinc
T2349 7607-7613 NN denotes finger
T2350 7614-7627 NN denotes transcription
T2351 7628-7634 NN denotes factor
T2352 7635-7641 NNP denotes GATA-3
T2353 7641-7642 , denotes ,
T2354 7643-7648 WDT denotes which
T2355 7649-7651 VBZ denotes is
T2356 7652-7665 RB denotes predominantly
T2357 7666-7675 VBN denotes expressed
T2358 7676-7678 IN denotes in
T2359 7679-7682 JJ denotes Th2
T2360 7683-7688 NNS denotes cells
T2361 7689-7690 VBP denotes [
T2362 7690-7691 CD denotes 2
T2363 7691-7692 NNP denotes ]
T2364 7692-7693 , denotes ,
T2365 7693-7694 NNP denotes [
T2366 7694-7695 CD denotes 3
T2367 7695-7696 NNP denotes ]
T2368 7696-7697 . denotes .
T2369 7698-7704 JJ denotes GATA-3
T2370 7705-7715 VBZ denotes determines
T2371 7716-7719 NNP denotes Th2
T2372 7720-7724 NN denotes cell
T2373 7725-7740 NN denotes differentiation
T2374 7741-7744 CC denotes and
T2375 7745-7756 RB denotes selectively
T2376 7757-7766 VBZ denotes activates
T2377 7767-7770 DT denotes the
T2378 7771-7780 NNS denotes promoters
T2379 7781-7783 IN denotes of
T2380 7784-7788 NN denotes IL-4
T2381 7788-7789 , denotes ,
T2382 7790-7794 NN denotes IL-5
T2383 7794-7795 , denotes ,
T2384 7796-7799 CC denotes and
T2385 7800-7805 NN denotes IL-13
T2386 7806-7813 IN denotes through
T2387 7814-7823 NN denotes chromatin
T2388 7824-7835 VBG denotes remodelling
T2389 7836-7837 NNP denotes [
T2390 7837-7838 CD denotes 4
T2391 7838-7839 NNP denotes ]
T2392 7840-7841 NN denotes [
T2393 7841-7842 CD denotes 7
T2394 7842-7843 NNP denotes ]
T2395 7843-7844 . denotes .
T2396 7845-7848 DT denotes The
T2397 7849-7852 JJ denotes key
T2398 7853-7857 NN denotes role
T2399 7858-7860 IN denotes of
T2400 7861-7867 NN denotes GATA-3
T2401 7868-7870 IN denotes in
T2402 7871-7879 JJ denotes allergic
T2403 7880-7886 NN denotes airway
T2404 7887-7899 NN denotes inflammation
T2405 7900-7903 VBZ denotes has
T2406 7904-7908 VBN denotes been
T2407 7909-7921 VBN denotes demonstrated
T2408 7922-7924 IN denotes in
T2409 7925-7929 NNS denotes mice
T2410 7930-7932 IN denotes by
T2411 7933-7936 DT denotes the
T2412 7937-7944 VBN denotes reduced
T2413 7945-7952 NN denotes release
T2414 7953-7955 IN denotes of
T2415 7956-7959 JJ denotes Th2
T2416 7960-7969 NNS denotes cytokines
T2417 7970-7972 IN denotes in
T2418 7973-7980 NNS denotes animals
T2419 7981-7988 VBN denotes treated
T2420 7989-7993 IN denotes with
T2421 7994-8011 JJ denotes dominant-negative
T2422 8012-8019 NNS denotes mutants
T2423 8020-8022 IN denotes of
T2424 8023-8029 NN denotes GATA-3
T2425 8030-8033 CC denotes and
T2426 8034-8036 IN denotes by
T2427 8037-8042 JJ denotes local
T2428 8043-8054 NN denotes application
T2429 8055-8057 IN denotes of
T2430 8058-8067 JJ denotes antisense
T2431 8068-8084 NNS denotes oligonucleotides
T2432 8085-8087 TO denotes to
T2433 8088-8094 NNP denotes GATA-3
T2434 8095-8096 NNP denotes [
T2435 8096-8097 CD denotes 8
T2436 8097-8098 NNP denotes ]
T2437 8098-8099 , denotes ,
T2438 8099-8100 NNP denotes [
T2439 8100-8101 CD denotes 9
T2440 8101-8102 NNP denotes ]
T2441 8102-8103 . denotes .
T2442 8104-8115 RB denotes Furthermore
T2443 8115-8116 , denotes ,
T2444 8117-8128 JJ denotes conditional
T2445 8129-8138 NN denotes knock-out
T2446 8139-8141 IN denotes of
T2447 8142-8145 DT denotes the
T2448 8146-8151 NNP denotes Gata3
T2449 8152-8156 NN denotes gene
T2450 8157-8159 IN denotes in
T2451 8160-8164 NNS denotes mice
T2452 8165-8172 VBZ denotes reduces
T2453 8173-8183 NN denotes expression
T2454 8184-8186 IN denotes of
T2455 8187-8190 JJ denotes Th2
T2456 8191-8200 NNS denotes cytokines
T2457 8201-8203 IN denotes in
T2458 8204-8209 NN denotes vitro
T2459 8210-8213 CC denotes and
T2460 8214-8216 IN denotes in
T2461 8217-8221 NN denotes vivo
T2462 8222-8223 NNP denotes [
T2463 8223-8225 CD denotes 10
T2464 8225-8226 NNP denotes ]
T2465 8226-8227 , denotes ,
T2466 8228-8231 CC denotes and
T2467 8232-8239 JJ denotes similar
T2468 8240-8247 NNS denotes results
T2469 8248-8252 VBP denotes have
T2470 8253-8257 VBN denotes been
T2471 8258-8266 VBN denotes reported
T2472 8267-8269 IN denotes in
T2473 8270-8278 JJ denotes isolated
T2474 8279-8285 NN denotes murine
T2475 8286-8289 NNP denotes CD4
T2476 8289-8290 NNP denotes +
T2477 8291-8302 VBZ denotes lymphocytes
T2478 8303-8304 NNP denotes [
T2479 8304-8306 CD denotes 11
T2480 8306-8307 NNP denotes ]
T2481 8307-8308 . denotes .
T2482 8309-8316 RB denotes Finally
T2483 8316-8317 , denotes ,
T2484 8318-8327 NN denotes knockdown
T2485 8328-8330 IN denotes of
T2486 8331-8337 JJ denotes GATA-3
T2487 8338-8348 NN denotes expression
T2488 8349-8354 VBG denotes using
T2489 8355-8360 NNP denotes siRNA
T2490 8361-8363 IN denotes in
T2491 8364-8369 JJ denotes human
T2492 8370-8371 NNP denotes T
T2493 8372-8377 NNS denotes cells
T2494 8378-8385 NNS denotes results
T2495 8386-8388 IN denotes in
T2496 8389-8393 NN denotes loss
T2497 8394-8396 IN denotes of
T2498 8397-8405 JJ denotes anti-CD3
T2499 8405-8406 NN denotes /
T2500 8406-8419 JJ denotes CD28-mediated
T2501 8420-8423 JJ denotes Th2
T2502 8424-8432 NN denotes cytokine
T2503 8433-8443 NN denotes expression
T2504 8444-8445 NNP denotes [
T2505 8445-8447 CD denotes 12
T2506 8447-8448 NNP denotes ]
T2507 8448-8449 . denotes .
T2508 8450-8452 IN denotes In
T2509 8453-8458 NN denotes order
T2510 8459-8462 IN denotes for
T2511 8463-8469 NN denotes GATA-3
T2512 8470-8472 TO denotes to
T2513 8473-8481 VB denotes regulate
T2514 8482-8486 NN denotes gene
T2515 8487-8497 NN denotes expression
T2516 8497-8498 , denotes ,
T2517 8499-8501 PRP denotes it
T2518 8502-8506 MD denotes must
T2519 8507-8518 VB denotes translocate
T2520 8519-8523 IN denotes from
T2521 8524-8527 DT denotes the
T2522 8528-8537 NN denotes cytoplasm
T2523 8538-8542 IN denotes into
T2524 8543-8546 DT denotes the
T2525 8547-8554 NN denotes nucleus
T2526 8555-8557 TO denotes to
T2527 8558-8564 VB denotes access
T2528 8565-8568 PRP$ denotes its
T2529 8569-8575 NN denotes target
T2530 8576-8581 NNS denotes genes
T2531 8581-8582 . denotes .
T2532 8583-8591 JJ denotes Enhanced
T2533 8592-8599 JJ denotes nuclear
T2534 8600-8610 NN denotes expression
T2535 8611-8613 IN denotes of
T2536 8614-8620 NN denotes GATA-3
T2537 8621-8630 VBG denotes following
T2538 8631-8632 NNP denotes T
T2539 8633-8637 NN denotes cell
T2540 8638-8646 NN denotes receptor
T2541 8647-8657 NN denotes activation
T2542 8658-8661 VBD denotes was
T2543 8662-8667 JJ denotes first
T2544 8668-8680 VBN denotes demonstrated
T2545 8681-8683 IN denotes in
T2546 8684-8690 NN denotes murine
T2547 8691-8692 NNP denotes T
T2548 8693-8698 NNS denotes cells
T2549 8699-8700 NNP denotes [
T2550 8700-8702 CD denotes 13
T2551 8702-8703 NNP denotes ]
T2552 8704-8707 CC denotes and
T2553 8708-8711 VBD denotes was
T2554 8712-8720 RB denotes recently
T2555 8721-8730 VBN denotes confirmed
T2556 8731-8733 IN denotes in
T2557 8734-8739 JJ denotes human
T2558 8740-8741 NNP denotes T
T2559 8742-8747 NNS denotes cells
T2560 8748-8757 VBG denotes following
T2561 8758-8759 NNP denotes T
T2562 8760-8764 NN denotes cell
T2563 8765-8773 NN denotes receptor
T2564 8774-8777 CC denotes and
T2565 8778-8789 NN denotes co-receptor
T2566 8790-8801 NN denotes stimulation
T2567 8802-8803 NNP denotes [
T2568 8803-8805 CD denotes 12
T2569 8805-8806 NNP denotes ]
T2570 8806-8807 . denotes .
T2571 8808-8814 JJ denotes GATA-3
T2572 8815-8823 VBZ denotes contains
T2573 8824-8825 DT denotes a
T2574 8826-8835 JJ denotes classical
T2575 8836-8843 JJ denotes nuclear
T2576 8844-8850 NN denotes import
T2577 8851-8857 NN denotes signal
T2578 8858-8859 NNP denotes [
T2579 8859-8861 CD denotes 14
T2580 8861-8862 NNP denotes ]
T2581 8863-8866 CC denotes and
T2582 8867-8869 VBZ denotes is
T2583 8870-8881 VBN denotes transported
T2584 8882-8886 IN denotes into
T2585 8887-8890 DT denotes the
T2586 8891-8898 NN denotes nucleus
T2587 8899-8901 IN denotes by
T2588 8902-8905 DT denotes the
T2589 8906-8913 JJ denotes nuclear
T2590 8914-8920 NN denotes import
T2591 8921-8928 NN denotes protein
T2592 8929-8939 NN denotes importin-α
T2593 8940-8941 -LRB- denotes (
T2594 8941-8945 RB denotes also
T2595 8946-8951 VBN denotes known
T2596 8952-8954 IN denotes as
T2597 8955-8968 NN denotes karyopherin-α
T2598 8968-8969 -RRB- denotes )
T2599 8970-8971 NNP denotes [
T2600 8971-8973 CD denotes 12
T2601 8973-8974 NNP denotes ]
T2602 8974-8975 . denotes .
T2603 8976-8984 NN denotes Deletion
T2604 8985-8987 IN denotes of
T2605 8988-8989 DT denotes a
T2606 8990-8996 NN denotes region
T2607 8997-9009 VBG denotes encompassing
T2608 9010-9013 DT denotes the
T2609 9014-9020 JJ denotes GATA-3
T2610 9021-9028 JJ denotes nuclear
T2611 9029-9041 NN denotes localisation
T2612 9042-9050 NN denotes sequence
T2613 9051-9052 -LRB- denotes (
T2614 9052-9055 NNP denotes NLS
T2615 9055-9056 -RRB- denotes )
T2616 9057-9063 NN denotes region
T2617 9064-9066 IN denotes in
T2618 9067-9073 NN denotes murine
T2619 9074-9077 CC denotes and
T2620 9078-9083 JJ denotes human
T2621 9084-9089 NNS denotes cells
T2622 9090-9098 VBZ denotes prevents
T2623 9099-9102 PRP$ denotes its
T2624 9103-9110 JJ denotes nuclear
T2625 9111-9123 NN denotes localisation
T2626 9124-9125 NNP denotes [
T2627 9125-9127 CD denotes 12
T2628 9127-9128 NNP denotes ]
T2629 9128-9129 , denotes ,
T2630 9129-9130 NNP denotes [
T2631 9130-9132 CD denotes 14
T2632 9132-9133 NNP denotes ]
T2633 9133-9134 . denotes .
T2634 9135-9138 DT denotes The
T2635 9139-9147 NN denotes affinity
T2636 9148-9150 IN denotes of
T2637 9151-9154 DT denotes the
T2638 9155-9165 JJ denotes importin-α
T2639 9166-9169 NNP denotes NLS
T2640 9170-9181 NN denotes interaction
T2641 9182-9184 VBZ denotes is
T2642 9185-9194 VBN denotes regulated
T2643 9195-9197 IN denotes by
T2644 9198-9213 NN denotes phosphorylation
T2645 9214-9215 NNP denotes [
T2646 9215-9217 CD denotes 15
T2647 9217-9218 NNP denotes ]
T2648 9218-9219 , denotes ,
T2649 9220-9223 CC denotes and
T2650 9224-9226 PRP denotes we
T2651 9227-9231 VBP denotes have
T2652 9232-9237 VBN denotes shown
T2653 9238-9242 IN denotes that
T2654 9243-9246 CD denotes p38
T2655 9247-9264 JJ denotes mitogen-activated
T2656 9265-9272 NN denotes protein
T2657 9273-9279 NN denotes kinase
T2658 9280-9281 -LRB- denotes (
T2659 9281-9285 NNP denotes MAPK
T2660 9285-9286 -RRB- denotes )
T2661 9287-9292 VBZ denotes plays
T2662 9293-9294 DT denotes a
T2663 9295-9303 JJ denotes critical
T2664 9304-9308 NN denotes role
T2665 9309-9311 IN denotes in
T2666 9312-9327 VBG denotes phosphorylating
T2667 9328-9334 NN denotes GATA-3
T2668 9335-9337 TO denotes to
T2669 9338-9345 VB denotes enhance
T2670 9346-9349 PRP$ denotes its
T2671 9350-9361 NN denotes interaction
T2672 9362-9366 IN denotes with
T2673 9367-9377 JJ denotes importin-α
T2674 9378-9381 CC denotes and
T2675 9382-9392 JJ denotes subsequent
T2676 9393-9402 NN denotes transport
T2677 9403-9407 IN denotes into
T2678 9408-9411 DT denotes the
T2679 9412-9419 NN denotes nucleus
T2680 9420-9421 NNP denotes [
T2681 9421-9423 CD denotes 12
T2682 9423-9424 NNP denotes ]
T2683 9424-9425 . denotes .
T2684 9426-9441 NNS denotes Corticosteroids
T2685 9442-9445 VBP denotes are
T2686 9446-9452 RB denotes highly
T2687 9453-9462 JJ denotes effective
T2688 9463-9465 IN denotes in
T2689 9466-9469 DT denotes the
T2690 9470-9479 NN denotes treatment
T2691 9480-9482 IN denotes of
T2692 9483-9491 JJ denotes allergic
T2693 9492-9504 NN denotes inflammation
T2694 9504-9505 , denotes ,
T2695 9506-9510 IN denotes with
T2696 9511-9517 JJ denotes marked
T2697 9518-9529 NN denotes suppression
T2698 9530-9532 IN denotes of
T2699 9533-9536 JJ denotes Th2
T2700 9537-9546 NNS denotes cytokines
T2701 9547-9549 IN denotes in
T2702 9550-9557 NNS denotes airways
T2703 9558-9560 IN denotes of
T2704 9561-9569 NNS denotes patients
T2705 9570-9574 IN denotes with
T2706 9575-9581 NN denotes asthma
T2707 9582-9583 NNP denotes [
T2708 9583-9585 CD denotes 16
T2709 9585-9586 NNP denotes ]
T2710 9586-9587 . denotes .
T2711 9588-9603 NNS denotes Corticosteroids
T2712 9604-9611 VBP denotes mediate
T2713 9612-9617 PRP$ denotes their
T2714 9618-9635 JJ denotes anti-inflammatory
T2715 9636-9643 NNS denotes effects
T2716 9644-9651 IN denotes through
T2717 9652-9659 JJ denotes binding
T2718 9660-9662 TO denotes to
T2719 9663-9677 JJ denotes glucocorticoid
T2720 9678-9687 NNS denotes receptors
T2721 9688-9689 -LRB- denotes (
T2722 9689-9692 NNS denotes GRs
T2723 9692-9693 -RRB- denotes )
T2724 9693-9694 , denotes ,
T2725 9695-9700 WDT denotes which
T2726 9701-9705 RB denotes then
T2727 9706-9717 VBP denotes translocate
T2728 9718-9720 TO denotes to
T2729 9721-9724 DT denotes the
T2730 9725-9732 NN denotes nucleus
T2731 9733-9738 WRB denotes where
T2732 9739-9743 PRP denotes they
T2733 9744-9752 VBP denotes interact
T2734 9753-9757 IN denotes with
T2735 9758-9772 JJ denotes glucocorticoid
T2736 9773-9781 NN denotes response
T2737 9782-9790 NNS denotes elements
T2738 9791-9792 -LRB- denotes (
T2739 9792-9796 NNS denotes GREs
T2740 9796-9797 -RRB- denotes )
T2741 9798-9800 IN denotes in
T2742 9801-9804 DT denotes the
T2743 9805-9813 NN denotes promoter
T2744 9814-9821 NNS denotes regions
T2745 9822-9824 IN denotes of
T2746 9825-9842 JJ denotes steroid-sensitive
T2747 9843-9848 NNS denotes genes
T2748 9848-9849 . denotes .
T2749 9850-9863 RB denotes Alternatively
T2750 9863-9864 , denotes ,
T2751 9865-9874 VBN denotes activated
T2752 9875-9877 NNP denotes GR
T2753 9878-9887 NNS denotes interacts
T2754 9888-9892 IN denotes with
T2755 9893-9904 NN denotes coactivator
T2756 9905-9914 NNS denotes molecules
T2757 9915-9917 TO denotes to
T2758 9918-9926 VB denotes suppress
T2759 9927-9930 DT denotes the
T2760 9931-9941 NN denotes expression
T2761 9942-9944 IN denotes of
T2762 9945-9957 JJ denotes inflammatory
T2763 9958-9963 NNS denotes genes
T2764 9964-9966 IN denotes by
T2765 9967-9977 VBG denotes inhibiting
T2766 9978-9981 DT denotes the
T2767 9982-9988 NN denotes action
T2768 9989-9991 IN denotes of
T2769 9992-10007 JJ denotes proinflammatory
T2770 10008-10021 NN denotes transcription
T2771 10022-10029 NNS denotes factors
T2772 10030-10034 JJ denotes such
T2773 10035-10037 IN denotes as
T2774 10038-10045 JJ denotes nuclear
T2775 10046-10055 NNP denotes factor-κB
T2776 10056-10057 -LRB- denotes (
T2777 10057-10062 NNP denotes NF-κB
T2778 10062-10063 -RRB- denotes )
T2779 10064-10071 IN denotes through
T2780 10072-10075 DT denotes the
T2781 10076-10087 NN denotes recruitment
T2782 10088-10090 IN denotes of
T2783 10091-10103 NN denotes co-repressor
T2784 10104-10113 NNS denotes molecules
T2785 10114-10118 JJ denotes such
T2786 10119-10121 IN denotes as
T2787 10122-10129 NN denotes histone
T2788 10130-10143 JJ denotes deacetylase-2
T2789 10144-10145 NNP denotes [
T2790 10145-10147 CD denotes 17
T2791 10147-10148 NNP denotes ]
T2792 10148-10149 , denotes ,
T2793 10149-10150 NNP denotes [
T2794 10150-10152 CD denotes 18
T2795 10152-10153 NNP denotes ]
T2796 10153-10154 . denotes .
T2797 10155-10162 NNP denotes Nuclear
T2798 10163-10175 NN denotes localisation
T2799 10176-10179 CC denotes and
T2800 10180-10189 NN denotes retention
T2801 10190-10192 IN denotes of
T2802 10193-10195 NNP denotes GR
T2803 10196-10198 VBZ denotes is
T2804 10199-10207 VBN denotes mediated
T2805 10208-10215 IN denotes through
T2806 10216-10219 DT denotes the
T2807 10220-10227 JJ denotes nuclear
T2808 10228-10240 NN denotes localisation
T2809 10241-10250 NNS denotes sequences
T2810 10251-10254 NNP denotes NL1
T2811 10255-10258 CC denotes and
T2812 10259-10262 NNP denotes NL2
T2813 10263-10264 NNP denotes [
T2814 10264-10266 CD denotes 19
T2815 10266-10267 NNP denotes ]
T2816 10267-10268 , denotes ,
T2817 10269-10271 IN denotes by
T2818 10272-10279 JJ denotes nuclear
T2819 10280-10289 NN denotes retention
T2820 10290-10297 VBZ denotes signals
T2821 10298-10299 NNP denotes [
T2822 10299-10301 CD denotes 20
T2823 10301-10302 NNP denotes ]
T2824 10302-10303 , denotes ,
T2825 10304-10307 CC denotes and
T2826 10308-10310 IN denotes by
T2827 10311-10318 NN denotes control
T2828 10319-10321 IN denotes of
T2829 10322-10329 JJ denotes nuclear
T2830 10330-10336 NN denotes export
T2831 10337-10340 IN denotes via
T2832 10341-10342 DT denotes a
T2833 10343-10354 JJ denotes chromosomal
T2834 10355-10361 NN denotes region
T2835 10362-10373 NN denotes maintenance
T2836 10374-10375 CD denotes 1
T2837 10376-10377 -LRB- denotes (
T2838 10377-10382 NN denotes CRM-1
T2839 10382-10383 -RRB- denotes )
T2840 10384-10393 JJ denotes dependent
T2841 10394-10401 NN denotes pathway
T2842 10402-10403 NNP denotes [
T2843 10403-10405 CD denotes 21
T2844 10405-10406 NNP denotes ]
T2845 10406-10407 . denotes .
T2846 10408-10411 CD denotes NL1
T2847 10411-10412 , denotes ,
T2848 10413-10418 WDT denotes which
T2849 10419-10421 VBZ denotes is
T2850 10422-10429 JJ denotes similar
T2851 10430-10432 TO denotes to
T2852 10433-10436 DT denotes the
T2853 10437-10441 NNP denotes SV40
T2854 10442-10445 NNP denotes NLS
T2855 10445-10446 , denotes ,
T2856 10447-10452 VBZ denotes binds
T2857 10453-10455 TO denotes to
T2858 10456-10466 VB denotes importin-α
T2859 10467-10468 NNP denotes [
T2860 10468-10470 CD denotes 22
T2861 10470-10471 NNP denotes ]
T2862 10471-10472 . denotes .
T2863 10473-10476 CD denotes NL1
T2864 10477-10479 VBZ denotes is
T2865 10480-10489 VBN denotes activated
T2866 10490-10494 DT denotes both
T2867 10495-10497 IN denotes by
T2868 10498-10512 JJ denotes glucocorticoid
T2869 10513-10521 NNS denotes agonists
T2870 10522-10526 JJ denotes such
T2871 10527-10529 IN denotes as
T2872 10530-10543 NN denotes dexamethasone
T2873 10544-10547 CC denotes and
T2874 10548-10559 NN denotes fluticasone
T2875 10560-10570 NN denotes propionate
T2876 10571-10572 -LRB- denotes (
T2877 10572-10574 NNP denotes FP
T2878 10574-10575 -RRB- denotes )
T2879 10576-10579 CC denotes and
T2880 10580-10582 IN denotes by
T2881 10583-10597 JJ denotes glucocorticoid
T2882 10598-10609 NNS denotes antagonists
T2883 10610-10614 JJ denotes such
T2884 10615-10617 IN denotes as
T2885 10618-10630 NN denotes mifepristone
T2886 10631-10632 -LRB- denotes (
T2887 10632-10637 NNP denotes RU486
T2888 10637-10638 -RRB- denotes )
T2889 10639-10640 NNP denotes [
T2890 10640-10642 CD denotes 23
T2891 10642-10643 NNP denotes ]
T2892 10643-10644 . denotes .
T2893 10645-10648 CD denotes NL1
T2894 10649-10652 MD denotes can
T2895 10653-10655 VB denotes be
T2896 10656-10663 VBN denotes mutated
T2897 10663-10664 , denotes ,
T2898 10665-10668 CC denotes and
T2899 10669-10672 DT denotes the
T2900 10673-10682 VBG denotes resulting
T2901 10683-10685 NNP denotes GR
T2902 10686-10691 RB denotes still
T2903 10692-10704 VBZ denotes translocates
T2904 10705-10707 TO denotes to
T2905 10708-10711 DT denotes the
T2906 10712-10719 NN denotes nucleus
T2907 10720-10722 IN denotes in
T2908 10723-10731 NN denotes response
T2909 10732-10734 TO denotes to
T2910 10735-10742 NNS denotes ligands
T2911 10742-10743 , denotes ,
T2912 10744-10747 CC denotes but
T2913 10748-10751 IN denotes via
T2914 10752-10763 NN denotes interaction
T2915 10764-10768 IN denotes with
T2916 10769-10777 NN denotes importin
T2917 10778-10779 CD denotes 7
T2918 10779-10780 , denotes ,
T2919 10781-10783 DT denotes an
T2920 10784-10789 NN denotes event
T2921 10790-10794 WDT denotes that
T2922 10795-10803 VBZ denotes requires
T2923 10804-10806 DT denotes an
T2924 10807-10813 RB denotes as-yet
T2925 10814-10821 JJ denotes unknown
T2926 10822-10831 NN denotes component
T2927 10832-10833 NNP denotes [
T2928 10833-10835 CD denotes 23
T2929 10835-10836 NNP denotes ]
T2930 10836-10837 . denotes .
T2931 10838-10841 CD denotes NL2
T2932 10842-10844 VBZ denotes is
T2933 10845-10851 RB denotes poorly
T2934 10852-10859 VBN denotes defined
T2935 10859-10860 , denotes ,
T2936 10861-10869 VBG denotes residing
T2937 10870-10872 IN denotes in
T2938 10873-10876 DT denotes the
T2939 10877-10891 JJ denotes ligand-binding
T2940 10892-10898 NN denotes domain
T2941 10898-10899 , denotes ,
T2942 10900-10903 CC denotes and
T2943 10904-10908 RB denotes much
T2944 10909-10913 JJR denotes less
T2945 10914-10916 VBZ denotes is
T2946 10917-10922 VBN denotes known
T2947 10923-10928 IN denotes about
T2948 10929-10932 PRP$ denotes its
T2949 10933-10942 NN denotes mechanism
T2950 10943-10945 IN denotes of
T2951 10946-10948 NNP denotes GR
T2952 10949-10955 NN denotes import
T2953 10956-10957 NNP denotes [
T2954 10957-10959 CD denotes 24
T2955 10959-10960 NNP denotes ]
T2956 10960-10961 . denotes .
T2957 10962-10963 DT denotes A
T2958 10964-10971 NN denotes variety
T2959 10972-10974 IN denotes of
T2960 10975-10980 JJ denotes other
T2961 10981-10988 NNS denotes factors
T2962 10989-10992 VBP denotes are
T2963 10993-10997 RB denotes also
T2964 10998-11007 JJ denotes important
T2965 11008-11011 IN denotes for
T2966 11012-11015 DT denotes the
T2967 11016-11026 NN denotes regulation
T2968 11027-11029 IN denotes of
T2969 11030-11032 NNP denotes GR
T2970 11033-11043 NN denotes activation
T2971 11044-11047 CC denotes and
T2972 11048-11055 JJ denotes nuclear
T2973 11056-11062 NN denotes import
T2974 11063-11072 VBG denotes including
T2975 11073-11083 NNS denotes chaperones
T2976 11084-11088 JJ denotes such
T2977 11089-11091 IN denotes as
T2978 11092-11097 NNP denotes Hsp90
T2979 11098-11101 CC denotes and
T2980 11102-11107 JJ denotes other
T2981 11108-11121 NNS denotes immunophilins
T2982 11122-11123 NNP denotes [
T2983 11123-11125 CD denotes 24
T2984 11125-11126 NNP denotes ]
T2985 11127-11128 NNP denotes [
T2986 11128-11130 CD denotes 26
T2987 11130-11131 NNP denotes ]
T2988 11132-11135 CC denotes and
T2989 11136-11149 JJ denotes FK506-binding
T2990 11150-11158 NNS denotes proteins
T2991 11159-11163 WDT denotes that
T2992 11164-11167 MD denotes may
T2993 11168-11170 VB denotes be
T2994 11171-11177 VBN denotes linked
T2995 11178-11180 TO denotes to
T2996 11181-11187 VB denotes dynein
T2997 11188-11194 CC denotes and/or
T2998 11195-11209 VB denotes peptidylprolyl
T2999 11210-11219 JJ denotes isomerase
T3000 11220-11221 NNP denotes [
T3001 11221-11223 CD denotes 27
T3002 11223-11224 NNP denotes ]
T3003 11224-11225 , denotes ,
T3004 11225-11226 NNP denotes [
T3005 11226-11228 CD denotes 28
T3006 11228-11229 NNP denotes ]
T3007 11229-11230 . denotes .
T3008 11231-11238 RB denotes However
T3009 11238-11239 , denotes ,
T3010 11240-11243 DT denotes the
T3011 11244-11253 JJ denotes molecular
T3012 11254-11259 NN denotes basis
T3013 11260-11263 IN denotes for
T3014 11264-11267 DT denotes the
T3015 11268-11278 NN denotes inhibition
T3016 11279-11281 IN denotes of
T3017 11282-11285 JJ denotes Th2
T3018 11286-11295 NNS denotes cytokines
T3019 11296-11298 IN denotes by
T3020 11299-11314 NNS denotes corticosteroids
T3021 11315-11317 VBZ denotes is
T3022 11318-11321 RB denotes not
T3023 11322-11326 RB denotes well
T3024 11327-11337 VBN denotes understood
T3025 11337-11338 , denotes ,
T3026 11339-11346 IN denotes because
T3027 11347-11350 DT denotes the
T3028 11351-11356 NNS denotes genes
T3029 11357-11365 VBG denotes encoding
T3030 11366-11370 NN denotes IL-4
T3031 11370-11371 , denotes ,
T3032 11372-11376 NN denotes IL-5
T3033 11376-11377 , denotes ,
T3034 11378-11381 CC denotes and
T3035 11382-11387 NNP denotes IL-13
T3036 11388-11390 VBP denotes do
T3037 11391-11394 RB denotes not
T3038 11395-11399 VB denotes have
T3039 11400-11403 DT denotes any
T3040 11404-11416 JJ denotes recognisable
T3041 11417-11420 NNP denotes GRE
T3042 11421-11429 NN denotes sequence
T3043 11430-11431 NNP denotes [
T3044 11431-11433 CD denotes 29
T3045 11433-11434 NNP denotes ]
T3046 11435-11438 CC denotes and
T3047 11439-11442 VBP denotes are
T3048 11443-11447 RB denotes only
T3049 11448-11454 RB denotes partly
T3050 11455-11464 VBN denotes regulated
T3051 11465-11467 IN denotes by
T3052 11468-11473 NNP denotes NF-κB
T3053 11474-11476 IN denotes in
T3054 11477-11482 JJ denotes human
T3055 11483-11488 NNS denotes cells
T3056 11489-11490 NNP denotes [
T3057 11490-11492 CD denotes 30
T3058 11492-11493 NNP denotes ]
T3059 11494-11495 NNP denotes [
T3060 11495-11497 CD denotes 32
T3061 11497-11498 NNP denotes ]
T3062 11498-11499 . denotes .
T3063 11500-11505 VBG denotes Using
T3064 11506-11520 NN denotes overexpression
T3065 11521-11524 CC denotes and
T3066 11525-11537 JJ denotes CAT-reporter
T3067 11538-11543 NNS denotes genes
T3068 11543-11544 , denotes ,
T3069 11545-11553 NNP denotes Lavender
T3070 11554-11557 CC denotes and
T3071 11558-11568 NNS denotes colleagues
T3072 11569-11570 NNP denotes [
T3073 11570-11572 CD denotes 33
T3074 11572-11573 NNP denotes ]
T3075 11574-11578 VBP denotes have
T3076 11579-11584 VBN denotes shown
T3077 11585-11589 IN denotes that
T3078 11590-11592 NNP denotes GR
T3079 11593-11600 VBD denotes reduced
T3080 11601-11616 JJ denotes GATA-3-mediated
T3081 11617-11621 NN denotes IL-5
T3082 11622-11625 CC denotes and
T3083 11626-11629 CD denotes -13
T3084 11630-11638 NN denotes promoter
T3085 11639-11647 NN denotes activity
T3086 11648-11650 IN denotes in
T3087 11651-11656 JJ denotes human
T3088 11657-11660 NNP denotes CD4
T3089 11660-11661 CD denotes +
T3090 11662-11663 NNP denotes T
T3091 11664-11669 NNS denotes cells
T3092 11669-11670 . denotes .
T3093 11671-11674 DT denotes The
T3094 11675-11682 NNS denotes authors
T3095 11683-11693 VBD denotes postulated
T3096 11694-11698 IN denotes that
T3097 11699-11704 JJ denotes local
T3098 11705-11716 NN denotes recruitment
T3099 11717-11719 IN denotes of
T3100 11720-11722 NNP denotes GR
T3101 11723-11726 MD denotes may
T3102 11727-11732 VB denotes alter
T3103 11733-11736 DT denotes the
T3104 11737-11744 NN denotes ability
T3105 11745-11747 IN denotes of
T3106 11748-11754 JJ denotes GATA-3
T3107 11755-11761 CC denotes either
T3108 11762-11764 TO denotes to
T3109 11765-11769 NN denotes bind
T3110 11770-11772 TO denotes to
T3111 11773-11776 PRP$ denotes its
T3112 11777-11783 NN denotes target
T3113 11784-11788 NN denotes site
T3114 11788-11789 , denotes ,
T3115 11790-11792 TO denotes to
T3116 11793-11798 VB denotes cause
T3117 11799-11814 JJ denotes transcriptional
T3118 11815-11828 NN denotes up-regulation
T3119 11828-11829 , denotes ,
T3120 11830-11832 CC denotes or
T3121 11833-11835 TO denotes to
T3122 11836-11844 VB denotes maintain
T3123 11845-11847 DT denotes an
T3124 11848-11859 NN denotes environment
T3125 11860-11864 WDT denotes that
T3126 11865-11867 VBZ denotes is
T3127 11868-11878 JJ denotes permissive
T3128 11879-11882 IN denotes for
T3129 11883-11896 NN denotes transcription
T3130 11896-11897 . denotes .
T3131 11898-11900 PRP denotes We
T3132 11901-11910 RB denotes therefore
T3133 11911-11923 VBD denotes investigated
T3134 11924-11927 DT denotes the
T3135 11928-11935 NNS denotes effects
T3136 11936-11938 IN denotes of
T3137 11939-11940 DT denotes a
T3138 11941-11950 JJ denotes synthetic
T3139 11951-11965 NN denotes corticosteroid
T3140 11965-11966 , denotes ,
T3141 11967-11969 NNP denotes FP
T3142 11969-11970 , denotes ,
T3143 11971-11973 IN denotes on
T3144 11974-11980 JJ denotes GATA-3
T3145 11981-11996 NN denotes phosphorylation
T3146 11997-12000 CC denotes and
T3147 12001-12008 JJ denotes nuclear
T3148 12009-12022 NN denotes translocation
T3149 12023-12025 IN denotes in
T3150 12026-12027 DT denotes a
T3151 12028-12029 NNP denotes T
T3152 12030-12040 NN denotes lymphocyte
T3153 12041-12045 NN denotes cell
T3154 12046-12050 NN denotes line
T3155 12051-12052 -LRB- denotes (
T3156 12052-12058 JJ denotes HuT-78
T3157 12058-12059 -RRB- denotes )
T3158 12060-12063 CC denotes and
T3159 12064-12066 IN denotes in
T3160 12067-12077 JJ denotes peripheral
T3161 12078-12083 NN denotes blood
T3162 12084-12095 NN denotes mononuclear
T3163 12096-12101 NNS denotes cells
T3164 12102-12111 VBN denotes activated
T3165 12112-12114 IN denotes by
T3166 12115-12123 JJ denotes anti-CD3
T3167 12124-12127 CC denotes and
T3168 12128-12137 JJ denotes anti-CD28
T3169 12138-12148 NNS denotes antibodies
T3170 12149-12151 IN denotes in
T3171 12152-12157 NN denotes vitro
T3172 12157-12158 . denotes .
T3173 12159-12161 PRP denotes We
T3174 12162-12166 RB denotes also
T3175 12167-12174 VBD denotes studied
T3176 12175-12178 DT denotes the
T3177 12179-12186 NNS denotes effects
T3178 12187-12189 IN denotes of
T3179 12190-12197 JJ denotes inhaled
T3180 12198-12209 NN denotes fluticasone
T3181 12210-12217 NN denotes therapy
T3182 12218-12220 IN denotes on
T3183 12221-12227 JJ denotes GATA-3
T3184 12228-12239 JJ denotes subcellular
T3185 12240-12252 NN denotes localization
T3186 12253-12255 IN denotes in
T3187 12256-12266 JJ denotes peripheral
T3188 12267-12272 NN denotes blood
T3189 12273-12284 NN denotes mononuclear
T3190 12285-12290 NNS denotes cells
T3191 12291-12292 -LRB- denotes (
T3192 12292-12297 NNS denotes PBMCs
T3193 12297-12298 -RRB- denotes )
T3194 12299-12303 IN denotes from
T3195 12304-12312 NNS denotes patients
T3196 12313-12317 IN denotes with
T3197 12318-12324 NN denotes asthma
T3198 12324-12325 . denotes .
T3810 12350-12362 NNS denotes Participants
T3811 12363-12366 CC denotes and
T3812 12367-12372 NNP denotes Study
T3813 12373-12379 NNP denotes Design
T3814 12380-12382 PRP denotes We
T3815 12383-12390 VBD denotes studied
T3816 12391-12399 NNS denotes patients
T3817 12400-12404 IN denotes with
T3818 12405-12409 JJ denotes mild
T3819 12410-12416 NN denotes asthma
T3820 12417-12420 WP denotes who
T3821 12421-12425 VBD denotes were
T3822 12426-12429 RB denotes not
T3823 12430-12437 VBN denotes treated
T3824 12438-12442 IN denotes with
T3825 12443-12450 JJ denotes inhaled
T3826 12451-12466 NNS denotes corticosteroids
T3827 12467-12470 WP denotes who
T3828 12471-12474 VBD denotes had
T3829 12475-12479 VBN denotes been
T3830 12480-12488 VBN denotes included
T3831 12489-12491 IN denotes in
T3832 12492-12493 DT denotes a
T3833 12494-12504 RB denotes previously
T3834 12505-12513 VBN denotes reported
T3835 12514-12526 NN denotes double-blind
T3836 12526-12527 , denotes ,
T3837 12528-12546 JJ denotes placebo-controlled
T3838 12546-12547 , denotes ,
T3839 12548-12557 JJ denotes crossover
T3840 12558-12563 NN denotes study
T3841 12564-12568 IN denotes with
T3842 12569-12571 NNP denotes FP
T3843 12572-12573 NNP denotes [
T3844 12573-12575 CD denotes 34
T3845 12575-12576 NNP denotes ]
T3846 12576-12577 . denotes .
T3847 12578-12583 CD denotes Seven
T3848 12584-12592 NNS denotes patients
T3849 12593-12597 IN denotes with
T3850 12598-12602 JJ denotes mild
T3851 12603-12609 NN denotes asthma
T3852 12610-12617 VBD denotes entered
T3853 12618-12621 DT denotes the
T3854 12622-12627 NN denotes study
T3855 12628-12631 CC denotes and
T3856 12632-12636 VBD denotes were
T3857 12637-12647 VBN denotes randomized
T3858 12648-12650 TO denotes to
T3859 12651-12658 VB denotes receive
T3860 12659-12660 DT denotes a
T3861 12661-12667 JJ denotes single
T3862 12668-12678 NN denotes inhalation
T3863 12679-12681 IN denotes of
T3864 12682-12684 NNP denotes FP
T3865 12685-12686 -LRB- denotes (
T3866 12686-12689 CD denotes 100
T3867 12690-12693 CC denotes and
T3868 12694-12697 CD denotes 500
T3869 12698-12700 NN denotes µg
T3870 12700-12701 -RRB- denotes )
T3871 12702-12704 CC denotes or
T3872 12705-12706 DT denotes a
T3873 12707-12714 VBN denotes matched
T3874 12715-12722 NN denotes placebo
T3875 12723-12730 NN denotes control
T3876 12731-12734 IN denotes via
T3877 12735-12736 DT denotes a
T3878 12737-12743 NN denotes spacer
T3879 12744-12751 NN denotes chamber
T3880 12751-12752 , denotes ,
T3881 12753-12756 CC denotes and
T3882 12757-12760 DT denotes the
T3883 12761-12766 JJ denotes other
T3884 12767-12776 NN denotes treatment
T3885 12777-12780 VBD denotes was
T3886 12781-12786 VBN denotes given
T3887 12787-12792 IN denotes after
T3888 12793-12794 DT denotes a
T3889 12795-12803 JJ denotes wash-out
T3890 12804-12810 NN denotes period
T3891 12811-12813 IN denotes of
T3892 12814-12816 IN denotes at
T3893 12817-12822 JJS denotes least
T3894 12823-12824 CD denotes 6
T3895 12825-12827 NN denotes d.
T3896 12828-12833 NNP denotes Blood
T3897 12834-12837 VBD denotes was
T3898 12838-12843 VBN denotes taken
T3899 12844-12847 IN denotes for
T3900 12848-12859 NN denotes preparation
T3901 12860-12862 IN denotes of
T3902 12863-12868 NNS denotes PBMCs
T3903 12869-12871 IN denotes at
T3904 12872-12873 CD denotes 1
T3905 12874-12877 CC denotes and
T3906 12878-12879 CD denotes 2
T3907 12880-12881 NN denotes h
T3908 12882-12887 IN denotes after
T3909 12888-12892 NN denotes drug
T3910 12893-12907 NN denotes administration
T3911 12907-12908 . denotes .
T3912 12909-12912 DT denotes All
T3913 12913-12921 NNS denotes patients
T3914 12922-12926 VBD denotes gave
T3915 12927-12935 VBN denotes informed
T3916 12936-12943 NN denotes consent
T3917 12944-12947 CC denotes and
T3918 12948-12951 DT denotes the
T3919 12952-12957 NN denotes study
T3920 12958-12961 VBD denotes was
T3921 12962-12970 VBN denotes approved
T3922 12971-12973 IN denotes by
T3923 12974-12977 DT denotes the
T3924 12978-12984 NNPS denotes Ethics
T3925 12985-12994 NNP denotes Committee
T3926 12995-12997 IN denotes of
T3927 12998-13001 DT denotes the
T3928 13002-13007 NNP denotes Royal
T3929 13008-13016 NNP denotes Brompton
T3930 13017-13020 CC denotes and
T3931 13021-13030 NNP denotes Harefield
T3932 13031-13040 NNPS denotes Hospitals
T3933 13041-13044 NNP denotes NHS
T3934 13045-13050 NNP denotes Trust
T3935 13050-13051 . denotes .
T3936 13052-13055 DT denotes The
T3937 13056-13064 JJ denotes clinical
T3938 13065-13070 NN denotes study
T3939 13071-13074 VBD denotes was
T3940 13075-13084 VBN denotes conducted
T3941 13085-13091 IN denotes before
T3942 13092-13095 DT denotes the
T3943 13096-13107 NN denotes requirement
T3944 13108-13111 IN denotes for
T3945 13112-13120 NNP denotes Clinical
T3946 13121-13126 NNP denotes Trial
T3947 13127-13139 NNP denotes Registration
T3948 13139-13140 . denotes .
T4142 13142-13152 NNS denotes Antibodies
T4143 13153-13156 CC denotes and
T4144 13157-13165 NNS denotes Reagents
T4145 13166-13169 DT denotes The
T4146 13170-13180 JJ denotes monoclonal
T4147 13181-13191 NNS denotes antibodies
T4148 13192-13199 IN denotes against
T4149 13200-13205 JJ denotes human
T4150 13206-13209 NNP denotes CD3
T4151 13209-13210 , denotes ,
T4152 13211-13215 NNP denotes CD28
T4153 13215-13216 , denotes ,
T4154 13217-13219 NNP denotes GR
T4155 13219-13220 , denotes ,
T4156 13221-13224 CC denotes and
T4157 13225-13235 JJ denotes importin-α
T4158 13236-13240 VBD denotes were
T4159 13241-13250 VBN denotes purchased
T4160 13251-13255 IN denotes from
T4161 13256-13258 NNP denotes BD
T4162 13259-13270 NNP denotes Biosciences
T4163 13271-13272 -LRB- denotes (
T4164 13272-13278 NNP denotes Oxford
T4165 13278-13279 , denotes ,
T4166 13280-13286 NNP denotes United
T4167 13287-13294 NNP denotes Kingdom
T4168 13294-13295 -RRB- denotes )
T4169 13295-13296 . denotes .
T4170 13297-13303 NN denotes Rabbit
T4171 13304-13314 NNS denotes antibodies
T4172 13315-13322 IN denotes against
T4173 13323-13328 JJ denotes human
T4174 13329-13335 NNP denotes GATA-3
T4175 13336-13337 -LRB- denotes (
T4176 13337-13341 NNP denotes H-48
T4177 13341-13342 -RRB- denotes )
T4178 13343-13346 CC denotes and
T4179 13347-13349 NNP denotes GR
T4180 13350-13351 -LRB- denotes (
T4181 13351-13355 NNP denotes E-20
T4182 13355-13356 , denotes ,
T4183 13357-13364 JJ denotes sc-1003
T4184 13364-13365 -RRB- denotes )
T4185 13366-13370 VBD denotes were
T4186 13371-13379 VBN denotes obtained
T4187 13380-13384 IN denotes from
T4188 13385-13390 NNP denotes Santa
T4189 13391-13395 NNP denotes Cruz
T4190 13396-13409 NNP denotes Biotechnology
T4191 13410-13411 -LRB- denotes (
T4192 13411-13416 NNP denotes Santa
T4193 13417-13421 NNP denotes Cruz
T4194 13421-13422 , denotes ,
T4195 13423-13433 NNP denotes California
T4196 13433-13434 , denotes ,
T4197 13435-13441 NNP denotes United
T4198 13442-13448 NNPS denotes States
T4199 13448-13449 -RRB- denotes )
T4200 13449-13450 , denotes ,
T4201 13451-13461 JJ denotes polyclonal
T4202 13462-13468 NN denotes rabbit
T4203 13469-13479 NNS denotes antibodies
T4204 13480-13487 IN denotes against
T4205 13488-13499 JJ denotes phospho-p38
T4206 13500-13503 NNP denotes MAP
T4207 13504-13510 NN denotes kinase
T4208 13511-13514 CC denotes and
T4209 13515-13528 NN denotes phospho-ATF-2
T4210 13529-13533 IN denotes from
T4211 13534-13538 NNP denotes Cell
T4212 13539-13548 NNP denotes Signaling
T4213 13549-13559 NNP denotes Technology
T4214 13560-13561 -LRB- denotes (
T4215 13561-13564 NNP denotes New
T4216 13565-13572 NNP denotes England
T4217 13573-13580 NNPS denotes Biolabs
T4218 13580-13581 , denotes ,
T4219 13582-13590 NNP denotes Hertford
T4220 13590-13591 , denotes ,
T4221 13592-13594 NNP denotes UK
T4222 13594-13595 -RRB- denotes )
T4223 13595-13596 , denotes ,
T4224 13597-13607 JJ denotes monoclonal
T4225 13608-13616 NN denotes antibody
T4226 13617-13624 IN denotes against
T4227 13625-13638 NN denotes phosphoserine
T4228 13639-13640 -LRB- denotes (
T4229 13640-13645 JJ denotes clone
T4230 13646-13649 NNP denotes 4H4
T4231 13649-13650 -RRB- denotes )
T4232 13651-13655 IN denotes from
T4233 13656-13664 NNP denotes Affiniti
T4234 13665-13673 NNP denotes Research
T4235 13674-13682 NNP denotes Products
T4236 13683-13684 -LRB- denotes (
T4237 13684-13690 NNP denotes Exeter
T4238 13690-13691 , denotes ,
T4239 13692-13694 NNP denotes UK
T4240 13694-13695 -RRB- denotes )
T4241 13695-13696 , denotes ,
T4242 13697-13700 CC denotes and
T4243 13701-13711 NNS denotes antibodies
T4244 13712-13719 IN denotes against
T4245 13720-13726 NN denotes rabbit
T4246 13727-13741 NNP denotes IgG-conjugated
T4247 13742-13747 NNP denotes TRITC
T4248 13748-13752 IN denotes from
T4249 13753-13757 NNP denotes Dako
T4250 13758-13768 NNP denotes Cytomation
T4251 13769-13770 -LRB- denotes (
T4252 13770-13779 NNP denotes Cambridge
T4253 13779-13780 , denotes ,
T4254 13781-13783 NNP denotes UK
T4255 13783-13784 -RRB- denotes )
T4256 13784-13785 . denotes .
T4257 13786-13789 DT denotes The
T4258 13790-13797 JJ denotes anti-GR
T4259 13798-13806 NN denotes antibody
T4260 13807-13808 -LRB- denotes (
T4261 13808-13813 NNP denotes Clone
T4262 13814-13816 CD denotes 41
T4263 13816-13817 -RRB- denotes )
T4264 13818-13822 IN denotes from
T4265 13823-13825 NNP denotes BD
T4266 13826-13838 NNP denotes Transduction
T4267 13839-13851 NNP denotes Laboratories
T4268 13852-13853 -LRB- denotes (
T4269 13853-13859 NNP denotes Oxford
T4270 13859-13860 , denotes ,
T4271 13861-13863 NNP denotes UK
T4272 13863-13864 -RRB- denotes )
T4273 13865-13868 VBD denotes was
T4274 13869-13873 VBN denotes used
T4275 13874-13877 IN denotes for
T4276 13878-13885 JJ denotes Western
T4277 13886-13890 NN denotes blot
T4278 13891-13899 NN denotes analysis
T4279 13899-13900 . denotes .
T4280 13901-13904 DT denotes All
T4281 13905-13910 JJ denotes other
T4282 13911-13919 NNS denotes reagents
T4283 13920-13924 VBD denotes were
T4284 13925-13934 VBN denotes purchased
T4285 13935-13939 IN denotes from
T4286 13940-13945 NNP denotes Sigma
T4287 13946-13947 -LRB- denotes (
T4288 13947-13952 NNP denotes Poole
T4289 13952-13953 , denotes ,
T4290 13954-13956 NNP denotes UK
T4291 13956-13957 -RRB- denotes )
T4292 13957-13958 . denotes .
T4470 13960-13964 NNP denotes Cell
T4471 13965-13972 NNP denotes Culture
T4472 13973-13976 CC denotes and
T4473 13977-13981 NNP denotes PBMC
T4474 13982-13991 NNP denotes Isolation
T4475 13992-13993 NNP denotes A
T4476 13994-13999 JJ denotes human
T4477 14000-14001 NNP denotes T
T4478 14002-14006 NN denotes cell
T4479 14007-14011 NN denotes line
T4480 14012-14013 -LRB- denotes (
T4481 14013-14019 JJ denotes HuT-78
T4482 14019-14020 -RRB- denotes )
T4483 14021-14024 VBD denotes was
T4484 14025-14034 VBN denotes purchased
T4485 14035-14039 IN denotes from
T4486 14040-14045 NNP denotes ECACC
T4487 14046-14054 NNP denotes European
T4488 14055-14065 NNP denotes Collection
T4489 14066-14068 IN denotes of
T4490 14069-14073 NNP denotes Cell
T4491 14074-14081 NNP denotes Culture
T4492 14082-14083 -LRB- denotes (
T4493 14083-14092 NNP denotes Wiltshire
T4494 14092-14093 , denotes ,
T4495 14094-14096 NNP denotes UK
T4496 14096-14097 -RRB- denotes )
T4497 14098-14102 VBD denotes were
T4498 14103-14111 VBN denotes cultured
T4499 14112-14114 IN denotes as
T4500 14115-14125 RB denotes previously
T4501 14126-14135 VBN denotes described
T4502 14136-14137 NNP denotes [
T4503 14137-14139 CD denotes 12
T4504 14139-14140 NNP denotes ]
T4505 14140-14141 . denotes .
T4506 14142-14147 NNS denotes PBMCs
T4507 14148-14152 VBD denotes were
T4508 14153-14161 VBN denotes isolated
T4509 14162-14164 IN denotes by
T4510 14165-14172 NN denotes density
T4511 14173-14187 NN denotes centrifugation
T4512 14188-14192 IN denotes over
T4513 14193-14207 NNP denotes Ficoll-Hypaque
T4514 14208-14209 -LRB- denotes (
T4515 14209-14216 NN denotes density
T4516 14216-14217 , denotes ,
T4517 14218-14223 CD denotes 1.077
T4518 14224-14228 NN denotes g/ml
T4519 14228-14229 : denotes ;
T4520 14230-14238 NNP denotes Amersham
T4521 14239-14250 NNP denotes Biosciences
T4522 14250-14251 , denotes ,
T4523 14252-14260 NNP denotes Amersham
T4524 14260-14261 , denotes ,
T4525 14262-14264 NNP denotes UK
T4526 14264-14265 -RRB- denotes )
T4527 14266-14268 IN denotes as
T4528 14269-14279 RB denotes previously
T4529 14280-14289 VBN denotes described
T4530 14290-14291 NNP denotes [
T4531 14291-14293 CD denotes 34
T4532 14293-14294 NNP denotes ]
T4533 14294-14295 . denotes .
T4534 14296-14301 NNS denotes Cells
T4535 14302-14306 VBD denotes were
T4536 14307-14317 VBN denotes stimulated
T4537 14318-14322 IN denotes with
T4538 14323-14331 JJ denotes anti-CD3
T4539 14331-14332 NN denotes /
T4540 14332-14336 NNP denotes CD28
T4541 14337-14338 -LRB- denotes (
T4542 14338-14339 CD denotes 1
T4543 14340-14342 NN denotes µg
T4544 14342-14343 NN denotes /
T4545 14343-14345 NN denotes ml
T4546 14346-14350 DT denotes each
T4547 14350-14351 -RRB- denotes )
T4548 14352-14355 IN denotes for
T4549 14356-14357 CD denotes 1
T4550 14358-14359 NN denotes h
T4551 14360-14362 IN denotes at
T4552 14363-14365 CD denotes 37
T4553 14365-14366 CD denotes °
T4554 14366-14367 NNP denotes C
T4555 14368-14370 TO denotes to
T4556 14371-14380 VB denotes stimulate
T4557 14381-14384 JJ denotes Th2
T4558 14385-14393 NN denotes cytokine
T4559 14394-14401 NN denotes release
T4560 14402-14404 IN denotes in
T4561 14405-14408 DT denotes the
T4562 14409-14417 NN denotes presence
T4563 14418-14420 CC denotes or
T4564 14421-14428 NN denotes absence
T4565 14429-14431 IN denotes of
T4566 14432-14434 NNP denotes FP
T4567 14435-14436 -LRB- denotes (
T4568 14436-14438 CD denotes 10
T4569 14438-14439 NN denotes −
T4570 14439-14441 CD denotes 12
T4571 14442-14444 TO denotes to
T4572 14445-14447 CD denotes 10
T4573 14447-14448 CD denotes −
T4574 14448-14450 NNP denotes 8M
T4575 14450-14451 -RRB- denotes )
T4576 14451-14452 . denotes .
T4577 14453-14462 NNS denotes Cytospins
T4578 14463-14467 VBD denotes were
T4579 14468-14476 JJ denotes prepared
T4580 14477-14480 CC denotes and
T4581 14481-14487 JJ denotes GATA-3
T4582 14488-14500 NN denotes localization
T4583 14501-14511 VBN denotes determined
T4584 14512-14514 IN denotes by
T4585 14515-14523 JJ denotes confocal
T4586 14524-14534 NN denotes microscopy
T4587 14535-14537 IN denotes as
T4588 14538-14548 RB denotes previously
T4589 14549-14558 VBN denotes described
T4590 14559-14560 NNP denotes [
T4591 14560-14562 CD denotes 12
T4592 14562-14563 NNP denotes ]
T4593 14563-14564 . denotes .
T4717 14566-14573 VB denotes Reverse
T4718 14574-14587 NNP denotes Transcription
T4719 14588-14591 NNP denotes PCR
T4720 14592-14597 NNP denotes Total
T4721 14598-14601 NNP denotes RNA
T4722 14602-14605 VBD denotes was
T4723 14606-14615 VBN denotes extracted
T4724 14616-14621 VBG denotes using
T4725 14622-14627 NN denotes lysis
T4726 14628-14634 NN denotes buffer
T4727 14635-14636 -LRB- denotes (
T4728 14636-14642 NNP denotes RNeasy
T4729 14643-14646 NN denotes kit
T4730 14646-14647 : denotes ;
T4731 14648-14654 NNP denotes Qiagen
T4732 14654-14655 , denotes ,
T4733 14656-14663 NNP denotes Crawley
T4734 14663-14664 , denotes ,
T4735 14665-14667 NNP denotes UK
T4736 14667-14668 -RRB- denotes )
T4737 14668-14669 . denotes .
T4738 14670-14676 IN denotes During
T4739 14677-14680 NNP denotes RNA
T4740 14681-14693 NN denotes purification
T4741 14693-14694 , denotes ,
T4742 14695-14702 JJ denotes genomic
T4743 14703-14706 NN denotes DNA
T4744 14707-14710 VBD denotes was
T4745 14711-14719 VBN denotes digested
T4746 14720-14724 IN denotes with
T4747 14725-14735 JJ denotes RNase-free
T4748 14736-14741 NNP denotes DNase
T4749 14742-14743 -LRB- denotes (
T4750 14743-14751 NNP denotes Amersham
T4751 14752-14763 NNPS denotes Biosciences
T4752 14763-14764 -RRB- denotes )
T4753 14764-14765 . denotes .
T4754 14766-14770 JJ denotes Next
T4755 14770-14771 , denotes ,
T4756 14772-14775 CD denotes 0.5
T4757 14776-14778 NN denotes µg
T4758 14779-14781 IN denotes of
T4759 14782-14787 JJ denotes total
T4760 14788-14791 NNP denotes RNA
T4761 14792-14795 VBD denotes was
T4762 14796-14804 JJ denotes reversed
T4763 14805-14816 VBN denotes transcribed
T4764 14817-14822 VBG denotes using
T4765 14823-14826 DT denotes the
T4766 14827-14832 JJ denotes avian
T4767 14833-14847 NN denotes myeloblastosis
T4768 14848-14853 NN denotes virus
T4769 14854-14856 NNP denotes RT
T4770 14857-14858 -LRB- denotes (
T4771 14858-14865 NNP denotes Promega
T4772 14865-14866 , denotes ,
T4773 14867-14878 NNP denotes Southampton
T4774 14878-14879 , denotes ,
T4775 14880-14882 NNP denotes UK
T4776 14882-14883 -RRB- denotes )
T4777 14883-14884 . denotes .
T4778 14885-14888 IN denotes For
T4779 14889-14897 JJ denotes relative
T4780 14898-14912 NN denotes quantification
T4781 14912-14913 , denotes ,
T4782 14914-14920 NN denotes RT-PCR
T4783 14921-14924 VBD denotes was
T4784 14925-14932 VBN denotes carried
T4785 14933-14936 IN denotes out
T4786 14937-14942 VBG denotes using
T4787 14943-14947 NNP denotes cDNA
T4788 14948-14954 NNS denotes probes
T4789 14954-14955 . denotes .
T4790 14956-14963 NNS denotes Primers
T4791 14964-14967 IN denotes for
T4792 14968-14972 NN denotes IL-4
T4793 14973-14977 VBD denotes were
T4794 14978-14982 IN denotes from
T4795 14983-14996 NNP denotes Sigma-Genosys
T4796 14997-14998 -LRB- denotes (
T4797 14998-15007 NNP denotes Cambridge
T4798 15007-15008 , denotes ,
T4799 15009-15011 NNP denotes UK
T4800 15011-15012 -RRB- denotes )
T4801 15012-15013 . denotes .
T4802 15014-15023 NNS denotes Sequences
T4803 15024-15026 IN denotes of
T4804 15027-15032 NNP denotes GADPH
T4805 15033-15037 VBD denotes used
T4806 15038-15041 VBP denotes are
T4807 15042-15044 IN denotes as
T4808 15045-15052 VBZ denotes follows
T4809 15052-15053 : denotes :
T4810 15054-15061 RB denotes forward
T4811 15062-15063 CD denotes 5
T4812 15063-15064 SYM denotes ′
T4813 15064-15065 : denotes -
T4814 15065-15088 NNP denotes CCACCCATGGCAAATTCCATGGC
T4815 15088-15089 , denotes ,
T4816 15090-15097 VB denotes reverse
T4817 15098-15099 CD denotes 3
T4818 15099-15100 SYM denotes ′
T4819 15100-15101 : denotes -
T4820 15101-15124 NNP denotes TCTAGACGGCAGGTCAGGTCCAC
T4821 15124-15125 . denotes .
T5013 15127-15131 NNP denotes Cell
T5014 15132-15145 NNP denotes Fractionation
T5015 15145-15146 , denotes ,
T5016 15147-15166 NNP denotes Immunoprecipitation
T5017 15166-15167 , denotes ,
T5018 15168-15171 CC denotes and
T5019 15172-15179 JJ denotes Western
T5020 15180-15184 NNP denotes Blot
T5021 15185-15193 NNP denotes Analysis
T5022 15194-15201 NNP denotes Nuclear
T5023 15202-15205 CC denotes and
T5024 15206-15217 JJ denotes cytoplasmic
T5025 15218-15227 NNS denotes fractions
T5026 15228-15232 VBD denotes were
T5027 15233-15241 VBN denotes prepared
T5028 15242-15244 IN denotes as
T5029 15245-15255 RB denotes previously
T5030 15256-15265 VBN denotes described
T5031 15266-15267 NNP denotes [
T5032 15267-15269 CD denotes 35
T5033 15269-15270 NNP denotes ]
T5034 15270-15271 . denotes .
T5035 15272-15277 JJ denotes Whole
T5036 15278-15282 NN denotes cell
T5037 15283-15290 NNS denotes lysates
T5038 15291-15295 VBD denotes were
T5039 15296-15304 VBN denotes prepared
T5040 15305-15307 IN denotes in
T5041 15308-15313 NN denotes NP-40
T5042 15314-15319 NN denotes lysis
T5043 15320-15326 NN denotes buffer
T5044 15327-15328 -LRB- denotes (
T5045 15328-15331 CD denotes 0.5
T5046 15331-15332 NN denotes %
T5047 15333-15340 NNP denotes Nonidet
T5048 15341-15345 NNP denotes P-40
T5049 15345-15346 , denotes ,
T5050 15347-15349 CD denotes 20
T5051 15350-15352 NNP denotes mM
T5052 15353-15361 NNP denotes Tris-HCl
T5053 15362-15363 NNP denotes [
T5054 15363-15365 NNP denotes pH
T5055 15366-15369 CD denotes 7.5
T5056 15369-15370 NNP denotes ]
T5057 15370-15371 , denotes ,
T5058 15372-15375 CD denotes 150
T5059 15376-15378 NNP denotes mM
T5060 15379-15383 NNP denotes NaCl
T5061 15383-15384 -RRB- denotes )
T5062 15385-15387 IN denotes in
T5063 15388-15391 DT denotes the
T5064 15392-15400 NN denotes presence
T5065 15401-15403 IN denotes of
T5066 15404-15412 JJ denotes complete
T5067 15413-15421 NN denotes protease
T5068 15422-15430 NN denotes cocktail
T5069 15431-15440 NN denotes inhibitor
T5070 15440-15441 . denotes .
T5071 15442-15449 NNS denotes Lysates
T5072 15450-15454 VBD denotes were
T5073 15455-15466 VBN denotes centrifuged
T5074 15467-15469 IN denotes at
T5075 15470-15471 CD denotes 4
T5076 15471-15472 CD denotes °
T5077 15472-15473 NNP denotes C
T5078 15474-15477 IN denotes for
T5079 15478-15480 CD denotes 10
T5080 15481-15484 NN denotes min
T5081 15485-15487 IN denotes at
T5082 15488-15494 CD denotes 12,000
T5083 15495-15498 NN denotes rpm
T5084 15499-15501 IN denotes in
T5085 15502-15504 DT denotes an
T5086 15505-15514 NNP denotes Eppendorf
T5087 15515-15530 NN denotes microcentrifuge
T5088 15531-15533 TO denotes to
T5089 15534-15540 VB denotes remove
T5090 15541-15549 JJ denotes cellular
T5091 15550-15556 NN denotes debris
T5092 15556-15557 . denotes .
T5093 15558-15565 NNS denotes Samples
T5094 15566-15570 VBD denotes were
T5095 15571-15575 RB denotes then
T5096 15576-15594 VBN denotes immunoprecipitated
T5097 15595-15599 IN denotes with
T5098 15600-15606 DT denotes either
T5099 15607-15609 CD denotes 10
T5100 15610-15612 NN denotes µl
T5101 15613-15615 IN denotes of
T5102 15616-15624 NN denotes antibody
T5103 15625-15632 IN denotes against
T5104 15633-15639 NNP denotes GATA-3
T5105 15640-15642 CC denotes or
T5106 15643-15653 JJ denotes importin-α
T5107 15654-15659 VBG denotes using
T5108 15660-15663 NNP denotes A/G
T5109 15664-15671 JJ denotes agarose
T5110 15672-15678 NN denotes slurry
T5111 15679-15681 IN denotes in
T5112 15682-15685 DT denotes the
T5113 15686-15694 NN denotes presence
T5114 15695-15697 IN denotes of
T5115 15698-15706 NN denotes protease
T5116 15707-15716 NN denotes inhibitor
T5117 15717-15722 VBG denotes using
T5118 15723-15726 DT denotes the
T5119 15727-15732 NNP denotes Catch
T5120 15733-15736 CC denotes and
T5121 15737-15744 NNP denotes Release
T5122 15745-15756 NN denotes methodology
T5123 15757-15758 -LRB- denotes (
T5124 15758-15765 NNP denotes Upstate
T5125 15766-15779 NNP denotes Biotechnology
T5126 15779-15780 , denotes ,
T5127 15781-15785 NNP denotes Lake
T5128 15786-15792 NNP denotes Placid
T5129 15792-15793 , denotes ,
T5130 15794-15797 NNP denotes New
T5131 15798-15802 NNP denotes York
T5132 15802-15803 , denotes ,
T5133 15804-15807 NNP denotes USA
T5134 15807-15808 -RRB- denotes )
T5135 15808-15809 . denotes .
T5136 15810-15817 JJ denotes Western
T5137 15818-15822 NN denotes blot
T5138 15823-15831 NN denotes analysis
T5139 15832-15835 VBD denotes was
T5140 15836-15845 VBN denotes performed
T5141 15846-15851 VBG denotes using
T5142 15852-15863 JJ denotes anti-GATA-3
T5143 15863-15864 , denotes ,
T5144 15865-15880 JJ denotes anti-importin-α
T5145 15880-15881 , denotes ,
T5146 15882-15889 JJ denotes anti-GR
T5147 15889-15890 , denotes ,
T5148 15891-15901 JJ denotes anti-p-p38
T5149 15902-15905 NNP denotes MAP
T5150 15906-15912 NN denotes kinase
T5151 15912-15913 , denotes ,
T5152 15914-15926 JJ denotes anti-p-ATF-2
T5153 15926-15927 , denotes ,
T5154 15928-15931 CC denotes and
T5155 15932-15945 JJ denotes anti-p-serine
T5156 15945-15946 . denotes .
T5157 15947-15961 JJ denotes Immunoreactive
T5158 15962-15970 NNS denotes proteins
T5159 15971-15975 VBD denotes were
T5160 15976-15984 VBN denotes detected
T5161 15985-15990 VBG denotes using
T5162 15991-15993 DT denotes an
T5163 15994-16002 JJ denotes enhanced
T5164 16003-16020 NN denotes chemiluminescence
T5165 16021-16024 NNP denotes ECL
T5166 16025-16028 NN denotes kit
T5167 16029-16030 -LRB- denotes (
T5168 16030-16038 NNP denotes Amersham
T5169 16039-16050 NNPS denotes Biosciences
T5170 16050-16051 -RRB- denotes )
T5171 16051-16052 . denotes .
T5318 16054-16063 NNP denotes Chromatin
T5319 16064-16083 NNP denotes Immunoprecipitation
T5320 16084-16093 NNP denotes Chromatin
T5321 16094-16113 NN denotes immunoprecipitation
T5322 16114-16115 -LRB- denotes (
T5323 16115-16117 NNP denotes IP
T5324 16117-16118 -RRB- denotes )
T5325 16119-16122 VBD denotes was
T5326 16123-16132 VBN denotes performed
T5327 16133-16135 IN denotes as
T5328 16136-16146 RB denotes previously
T5329 16147-16156 VBN denotes described
T5330 16157-16158 NNP denotes [
T5331 16158-16160 CD denotes 12
T5332 16160-16161 NNP denotes ]
T5333 16162-16164 IN denotes in
T5334 16165-16171 NNP denotes HuT-78
T5335 16172-16179 NNS denotes T-cells
T5336 16180-16184 IN denotes with
T5337 16185-16186 CD denotes 2
T5338 16187-16189 NN denotes µg
T5339 16190-16192 IN denotes of
T5340 16193-16204 JJ denotes anti-GATA-3
T5341 16205-16206 -LRB- denotes (
T5342 16206-16211 NNP denotes Santa
T5343 16212-16216 NNP denotes Cruz
T5344 16217-16230 NNP denotes Biotechnology
T5345 16230-16231 -RRB- denotes )
T5346 16231-16232 , denotes ,
T5347 16233-16235 CC denotes or
T5348 16236-16244 JJ denotes isotypic
T5349 16245-16259 NN denotes immunoglobulin
T5350 16260-16261 NNP denotes G
T5351 16262-16264 IN denotes as
T5352 16265-16266 DT denotes a
T5353 16267-16279 JJ denotes non-specific
T5354 16280-16287 NN denotes control
T5355 16288-16289 -LRB- denotes (
T5356 16289-16294 NNP denotes Santa
T5357 16295-16299 NNP denotes Cruz
T5358 16300-16313 NNP denotes Biotechnology
T5359 16313-16314 -RRB- denotes )
T5360 16315-16324 RB denotes overnight
T5361 16325-16327 IN denotes at
T5362 16328-16329 CD denotes 4
T5363 16329-16330 CD denotes °
T5364 16330-16332 NNP denotes C.
T5365 16333-16341 NNP denotes Promoter
T5366 16342-16351 NNS denotes sequences
T5367 16352-16356 VBD denotes were
T5368 16357-16365 VBN denotes detected
T5369 16366-16370 IN denotes with
T5370 16371-16374 NNP denotes PCR
T5371 16375-16382 NNS denotes primers
T5372 16383-16386 IN denotes for
T5373 16387-16390 DT denotes the
T5374 16391-16395 NN denotes IL-5
T5375 16396-16404 NN denotes promoter
T5376 16405-16406 -LRB- denotes (
T5377 16406-16407 FW denotes −
T5378 16407-16410 CD denotes 445
T5379 16411-16413 TO denotes to
T5380 16414-16416 CD denotes +4
T5381 16416-16417 -RRB- denotes )
T5382 16417-16418 : denotes :
T5383 16419-16426 RB denotes forward
T5384 16427-16428 CD denotes 5
T5385 16428-16429 SYM denotes ′
T5386 16429-16430 : denotes -
T5387 16430-16453 NN denotes TTAATCTAGCCACAGTCATAG-3
T5388 16453-16454 NN denotes ′
T5389 16455-16458 CC denotes and
T5390 16459-16466 NN denotes reverse
T5391 16466-16467 : denotes :
T5392 16468-16469 CD denotes 5
T5393 16469-16470 SYM denotes ′
T5394 16470-16471 : denotes -
T5395 16471-16494 NN denotes TCATGGCTCTGAAACGTTCTG-3
T5396 16494-16495 NN denotes ′
T5397 16495-16496 . denotes .
T5398 16497-16500 NNP denotes PCR
T5399 16501-16504 VBD denotes was
T5400 16505-16514 VBN denotes performed
T5401 16515-16520 VBG denotes using
T5402 16521-16522 DT denotes a
T5403 16523-16529 NNP denotes Hybaid
T5404 16530-16538 NNP denotes Omnigene
T5405 16539-16546 JJ denotes thermal
T5406 16547-16553 NN denotes cycler
T5407 16554-16555 -LRB- denotes (
T5408 16555-16561 NNP denotes Hybaid
T5409 16561-16562 , denotes ,
T5410 16563-16570 NNP denotes Ashford
T5411 16570-16571 , denotes ,
T5412 16572-16574 NNP denotes UK
T5413 16574-16575 -RRB- denotes )
T5414 16576-16580 IN denotes with
T5415 16581-16588 NN denotes cycling
T5416 16589-16599 NNS denotes parameters
T5417 16600-16602 IN denotes of
T5418 16603-16605 CD denotes 72
T5419 16605-16606 CD denotes °
T5420 16606-16607 NNP denotes C
T5421 16608-16611 IN denotes for
T5422 16612-16614 CD denotes 10
T5423 16615-16618 NN denotes min
T5424 16618-16619 , denotes ,
T5425 16620-16622 CD denotes 35
T5426 16623-16629 NNS denotes cycles
T5427 16630-16632 IN denotes at
T5428 16633-16635 CD denotes 94
T5429 16635-16636 CD denotes °
T5430 16636-16637 NNP denotes C
T5431 16638-16641 IN denotes for
T5432 16642-16644 CD denotes 45
T5433 16645-16646 PRP denotes s
T5434 16646-16647 , denotes ,
T5435 16648-16650 CD denotes 52
T5436 16650-16651 NN denotes °
T5437 16651-16652 NNP denotes C
T5438 16653-16656 IN denotes for
T5439 16657-16659 CD denotes 45
T5440 16660-16661 PRP denotes s
T5441 16661-16662 , denotes ,
T5442 16663-16665 CD denotes 72
T5443 16665-16666 NN denotes °
T5444 16666-16667 NNP denotes C
T5445 16668-16671 IN denotes for
T5446 16672-16674 CD denotes 45
T5447 16675-16677 NN denotes s.
T5754 16679-16688 CD denotes GR-GATA-3
T5755 16689-16691 IN denotes In
T5756 16692-16697 NNP denotes Vitro
T5757 16698-16709 NNP denotes Competition
T5758 16710-16715 NNP denotes Assay
T5759 16716-16719 IN denotes for
T5760 16720-16730 NNP denotes Importin-α
T5761 16731-16732 -LRB- denotes (
T5762 16732-16743 NNP denotes Far-Western
T5763 16744-16749 NNP denotes ELISA
T5764 16749-16750 -RRB- denotes )
T5765 16751-16769 NNP denotes Immunoprecipitated
T5766 16770-16780 NN denotes importin-α
T5767 16781-16782 -LRB- denotes (
T5768 16782-16797 JJ denotes anti-importin-α
T5769 16797-16798 , denotes ,
T5770 16799-16804 NNP denotes Santa
T5771 16805-16809 NNP denotes Cruz
T5772 16810-16823 NNP denotes Biotechnology
T5773 16823-16824 -RRB- denotes )
T5774 16825-16829 IN denotes from
T5775 16830-16836 JJ denotes HuT-78
T5776 16837-16842 NNS denotes cells
T5777 16843-16846 VBD denotes was
T5778 16847-16856 VBN denotes separated
T5779 16857-16859 IN denotes by
T5780 16860-16868 NNP denotes SDS-PAGE
T5781 16869-16872 CC denotes and
T5782 16873-16881 VBN denotes purified
T5783 16882-16886 IN denotes from
T5784 16887-16890 DT denotes the
T5785 16891-16898 VBN denotes excised
T5786 16899-16902 NN denotes gel
T5787 16903-16905 IN denotes by
T5788 16906-16920 NN denotes electroelution
T5789 16921-16922 NNP denotes [
T5790 16922-16924 CD denotes 36
T5791 16924-16925 NNP denotes ]
T5792 16925-16926 . denotes .
T5793 16927-16936 RB denotes Similarly
T5794 16936-16937 , denotes ,
T5795 16938-16944 NN denotes GATA-3
T5796 16945-16948 VBD denotes was
T5797 16949-16957 VBN denotes isolated
T5798 16958-16962 IN denotes from
T5799 16963-16976 JJ denotes nonstimulated
T5800 16977-16983 JJ denotes HuT-78
T5801 16984-16989 NNS denotes cells
T5802 16990-16992 CC denotes or
T5803 16993-16998 NNS denotes cells
T5804 16999-17009 VBD denotes stimulated
T5805 17010-17013 IN denotes for
T5806 17014-17016 CD denotes 30
T5807 17017-17020 NN denotes min
T5808 17021-17025 IN denotes with
T5809 17026-17034 JJ denotes anti-CD3
T5810 17034-17035 NN denotes /
T5811 17035-17039 CD denotes CD28
T5812 17040-17043 CC denotes and
T5813 17044-17046 NNP denotes GR
T5814 17047-17050 VBD denotes was
T5815 17051-17059 VBN denotes isolated
T5816 17060-17064 IN denotes from
T5817 17065-17067 NNP denotes FP
T5818 17068-17069 -LRB- denotes (
T5819 17069-17071 CD denotes 10
T5820 17071-17072 NN denotes −
T5821 17072-17073 CD denotes 8
T5822 17074-17075 NNP denotes M
T5823 17075-17076 , denotes ,
T5824 17077-17079 CD denotes 30
T5825 17080-17083 NN denotes min
T5826 17083-17084 -RRB- denotes )
T5827 17085-17095 VBD denotes stimulated
T5828 17096-17102 JJ denotes HuT-78
T5829 17103-17108 NNS denotes cells
T5830 17108-17109 . denotes .
T5831 17110-17115 DT denotes These
T5832 17116-17124 NNS denotes proteins
T5833 17125-17129 VBD denotes were
T5834 17130-17142 RB denotes subsequently
T5835 17143-17151 VBN denotes refolded
T5836 17152-17154 IN denotes in
T5837 17155-17162 NN denotes glycine
T5838 17163-17171 NN denotes solution
T5839 17171-17172 . denotes .
T5840 17173-17176 CD denotes 100
T5841 17177-17179 NN denotes µl
T5842 17180-17182 IN denotes of
T5843 17183-17193 JJ denotes importin-α
T5844 17194-17202 NN denotes solution
T5845 17203-17204 -LRB- denotes (
T5846 17204-17207 CD denotes 100
T5847 17208-17213 NN denotes ng/ml
T5848 17214-17216 IN denotes in
T5849 17217-17220 NNP denotes TBS
T5850 17220-17221 -RRB- denotes )
T5851 17222-17225 VBD denotes was
T5852 17226-17231 VBN denotes added
T5853 17232-17234 TO denotes to
T5854 17235-17242 JJ denotes 96-well
T5855 17243-17249 NNS denotes plates
T5856 17250-17256 VBN denotes coated
T5857 17257-17261 IN denotes with
T5858 17262-17266 NN denotes goat
T5859 17267-17282 JJ denotes anti-importin-α
T5860 17283-17291 NN denotes antibody
T5861 17291-17292 . denotes .
T5862 17293-17298 IN denotes After
T5863 17299-17300 CD denotes 1
T5864 17301-17302 NN denotes h
T5865 17303-17313 NN denotes incubation
T5866 17313-17314 , denotes ,
T5867 17315-17321 NNP denotes GATA-3
T5868 17322-17323 -LRB- denotes (
T5869 17323-17326 CD denotes 100
T5870 17327-17332 NN denotes ng/ml
T5871 17333-17335 IN denotes in
T5872 17336-17339 NNP denotes TBS
T5873 17339-17340 -RRB- denotes )
T5874 17341-17345 IN denotes from
T5875 17346-17356 VBN denotes stimulated
T5876 17357-17359 CC denotes or
T5877 17360-17372 JJ denotes unstimulated
T5878 17373-17378 NNS denotes cells
T5879 17379-17383 VBD denotes were
T5880 17384-17389 VBN denotes added
T5881 17390-17392 TO denotes to
T5882 17393-17396 DT denotes the
T5883 17397-17414 JJ denotes importin-α-coated
T5884 17415-17420 NNS denotes wells
T5885 17420-17421 . denotes .
T5886 17422-17424 NNP denotes GR
T5887 17425-17426 -LRB- denotes (
T5888 17426-17428 CD denotes 10
T5889 17429-17431 CC denotes or
T5890 17432-17435 CD denotes 100
T5891 17436-17441 NN denotes ng/ml
T5892 17442-17444 IN denotes in
T5893 17445-17448 NNP denotes TBS
T5894 17448-17449 -RRB- denotes )
T5895 17450-17454 IN denotes from
T5896 17455-17465 VBN denotes stimulated
T5897 17466-17468 CC denotes or
T5898 17469-17481 JJ denotes unstimulated
T5899 17482-17487 NNS denotes cells
T5900 17488-17492 VBD denotes were
T5901 17493-17498 VBN denotes added
T5902 17499-17501 TO denotes to
T5903 17502-17506 DT denotes some
T5904 17507-17512 NNS denotes wells
T5905 17512-17513 . denotes .
T5906 17514-17519 IN denotes After
T5907 17520-17521 DT denotes a
T5908 17522-17529 JJ denotes further
T5909 17530-17531 CD denotes 1
T5910 17532-17533 NN denotes h
T5911 17534-17544 NN denotes incubation
T5912 17544-17545 , denotes ,
T5913 17546-17549 DT denotes the
T5914 17550-17555 NN denotes plate
T5915 17556-17559 VBD denotes was
T5916 17560-17566 VBN denotes washed
T5917 17567-17570 CC denotes and
T5918 17571-17580 VBN denotes incubated
T5919 17581-17585 IN denotes with
T5920 17586-17593 JJ denotes primary
T5921 17594-17604 NNS denotes antibodies
T5922 17605-17606 -LRB- denotes (
T5923 17606-17607 DT denotes a
T5924 17608-17615 NN denotes mixture
T5925 17616-17618 IN denotes of
T5926 17619-17625 NN denotes rabbit
T5927 17626-17637 JJ denotes anti-GATA-3
T5928 17638-17641 CC denotes and
T5929 17642-17647 NN denotes mouse
T5930 17648-17655 JJ denotes anti-GR
T5931 17655-17656 , denotes ,
T5932 17657-17662 NNP denotes Santa
T5933 17663-17667 NNP denotes Cruz
T5934 17668-17681 NNP denotes Biotechnology
T5935 17681-17682 -RRB- denotes )
T5936 17683-17686 IN denotes for
T5937 17687-17690 CD denotes 1.5
T5938 17691-17692 NN denotes h
T5939 17692-17693 , denotes ,
T5940 17694-17697 CC denotes and
T5941 17698-17702 RB denotes then
T5942 17703-17712 VBN denotes incubated
T5943 17713-17717 IN denotes with
T5944 17718-17727 JJ denotes secondary
T5945 17728-17738 NNS denotes antibodies
T5946 17738-17739 . denotes .
T5947 17740-17744 CD denotes FITC
T5948 17745-17750 NNS denotes swine
T5949 17751-17762 JJ denotes anti-rabbit
T5950 17763-17766 NNP denotes IgG
T5951 17767-17768 -LRB- denotes (
T5952 17768-17772 NNP denotes Dako
T5953 17772-17773 , denotes ,
T5954 17774-17783 NNP denotes Cambridge
T5955 17783-17784 , denotes ,
T5956 17785-17787 NNP denotes UK
T5957 17787-17788 -RRB- denotes )
T5958 17789-17792 VBD denotes was
T5959 17793-17797 VBN denotes used
T5960 17798-17801 IN denotes for
T5961 17802-17805 DT denotes the
T5962 17806-17815 NN denotes detection
T5963 17816-17818 IN denotes of
T5964 17819-17825 NNP denotes GATA-3
T5965 17825-17826 , denotes ,
T5966 17827-17830 CC denotes and
T5967 17831-17840 JJ denotes rhodamine
T5968 17841-17847 NN denotes donkey
T5969 17848-17858 JJ denotes anti-mouse
T5970 17859-17862 NNP denotes IgG
T5971 17863-17864 -LRB- denotes (
T5972 17864-17869 NNP denotes Novus
T5973 17869-17870 , denotes ,
T5974 17871-17880 NNP denotes Littleton
T5975 17880-17881 , denotes ,
T5976 17882-17890 NNP denotes Colorado
T5977 17890-17891 , denotes ,
T5978 17892-17895 NNP denotes USA
T5979 17895-17896 -RRB- denotes )
T5980 17897-17900 VBD denotes was
T5981 17901-17905 VBN denotes used
T5982 17906-17909 IN denotes for
T5983 17910-17913 DT denotes the
T5984 17914-17923 NN denotes detection
T5985 17924-17926 IN denotes of
T5986 17927-17929 NNP denotes GR
T5987 17929-17930 . denotes .
T5988 17931-17935 NNP denotes FITC
T5989 17936-17939 CC denotes and
T5990 17940-17949 JJ denotes rhodamine
T5991 17950-17956 NNS denotes levels
T5992 17957-17961 VBD denotes were
T5993 17962-17970 VBN denotes measured
T5994 17971-17975 IN denotes with
T5995 17976-17977 DT denotes a
T5996 17978-17989 JJ denotes fluorescent
T5997 17990-18001 JJ denotes micro-plate
T5998 18002-18008 NN denotes reader
T5999 18009-18010 -LRB- denotes (
T6000 18010-18017 NNP denotes Bioline
T6001 18017-18018 , denotes ,
T6002 18019-18025 NNP denotes London
T6003 18025-18026 , denotes ,
T6004 18027-18029 NNP denotes UK
T6005 18029-18030 -RRB- denotes )
T6006 18030-18031 . denotes .
T6161 18033-18038 NNP denotes NF-κB
T6162 18039-18049 NNP denotes Activation
T6163 18050-18055 NNP denotes NF-κB
T6164 18056-18063 JJ denotes binding
T6165 18064-18072 NN denotes activity
T6166 18073-18075 IN denotes in
T6167 18076-18083 JJ denotes nuclear
T6168 18084-18092 NNS denotes extracts
T6169 18093-18096 VBD denotes was
T6170 18097-18107 VBN denotes determined
T6171 18108-18113 VBG denotes using
T6172 18114-18116 DT denotes an
T6173 18117-18128 JJ denotes ELISA-based
T6174 18129-18132 NN denotes kit
T6175 18133-18134 -LRB- denotes (
T6176 18134-18142 JJ denotes Trans-AM
T6177 18143-18146 NNS denotes p65
T6178 18146-18147 , denotes ,
T6179 18148-18154 NNP denotes Active
T6180 18155-18160 NNP denotes Motif
T6181 18160-18161 , denotes ,
T6182 18162-18171 NNP denotes Rixensart
T6183 18171-18172 , denotes ,
T6184 18173-18180 NNP denotes Belgium
T6185 18180-18181 -RRB- denotes )
T6186 18181-18182 . denotes .
T6187 18183-18185 IN denotes In
T6188 18186-18191 NN denotes brief
T6189 18191-18192 , denotes ,
T6190 18193-18194 CD denotes 5
T6191 18195-18197 NN denotes µg
T6192 18198-18200 IN denotes of
T6193 18201-18208 JJ denotes nuclear
T6194 18209-18217 NNS denotes extracts
T6195 18218-18222 VBD denotes were
T6196 18223-18232 VBN denotes incubated
T6197 18233-18237 IN denotes with
T6198 18238-18239 DT denotes a
T6199 18240-18245 NN denotes plate
T6200 18246-18252 VBN denotes coated
T6201 18253-18257 IN denotes with
T6202 18258-18260 DT denotes an
T6203 18261-18266 JJ denotes NF-κB
T6204 18267-18276 NN denotes consensus
T6205 18277-18292 NN denotes oligonucleotide
T6206 18292-18293 . denotes .
T6207 18294-18300 NNS denotes Plates
T6208 18301-18305 VBD denotes were
T6209 18306-18312 VBN denotes washed
T6210 18313-18319 IN denotes before
T6211 18320-18328 NN denotes addition
T6212 18329-18331 IN denotes of
T6213 18332-18334 DT denotes an
T6214 18335-18343 JJ denotes anti-p65
T6215 18344-18352 NN denotes antibody
T6216 18352-18353 . denotes .
T6217 18354-18362 NN denotes Antibody
T6218 18363-18370 JJ denotes binding
T6219 18371-18374 VBD denotes was
T6220 18375-18383 VBN denotes detected
T6221 18384-18388 IN denotes with
T6222 18389-18390 DT denotes a
T6223 18391-18400 JJ denotes secondary
T6224 18401-18415 JJ denotes HRP-conjugated
T6225 18416-18424 NN denotes antibody
T6226 18425-18428 CC denotes and
T6227 18429-18438 VBN denotes developed
T6228 18439-18443 IN denotes with
T6229 18444-18447 NNP denotes TMB
T6230 18448-18457 NN denotes substrate
T6231 18457-18458 . denotes .
T6232 18459-18462 DT denotes The
T6233 18463-18472 NN denotes intensity
T6234 18473-18475 IN denotes of
T6235 18476-18479 DT denotes the
T6236 18480-18488 NN denotes reaction
T6237 18489-18492 VBD denotes was
T6238 18493-18501 VBN denotes measured
T6239 18502-18504 IN denotes at
T6240 18505-18508 CD denotes 450
T6241 18509-18511 NN denotes nm
T6242 18511-18512 . denotes .
T6486 18514-18532 NNP denotes Immunofluorescence
T6487 18533-18541 NNP denotes Staining
T6488 18542-18560 NNP denotes Immunofluorescence
T6489 18561-18569 VBG denotes staining
T6490 18570-18573 VBD denotes was
T6491 18574-18583 VBN denotes performed
T6492 18584-18586 IN denotes as
T6493 18587-18597 RB denotes previously
T6494 18598-18607 VBN denotes described
T6495 18608-18609 NNP denotes [
T6496 18609-18611 CD denotes 34
T6497 18611-18612 NNP denotes ]
T6498 18612-18613 . denotes .
T6499 18614-18617 DT denotes All
T6500 18618-18626 VBG denotes staining
T6501 18627-18630 VBD denotes was
T6502 18631-18640 VBN denotes performed
T6503 18641-18643 IN denotes at
T6504 18644-18648 NN denotes room
T6505 18649-18660 NN denotes temperature
T6506 18661-18664 CC denotes and
T6507 18665-18670 IN denotes under
T6508 18671-18685 NN denotes humidification
T6509 18685-18686 . denotes .
T6510 18687-18692 NNS denotes Cells
T6511 18693-18697 VBD denotes were
T6512 18698-18707 VBN denotes collected
T6513 18708-18711 CC denotes and
T6514 18712-18721 NNS denotes cytospins
T6515 18722-18730 VBN denotes prepared
T6516 18731-18733 IN denotes in
T6517 18734-18735 DT denotes a
T6518 18736-18750 NN denotes cytocentrifuge
T6519 18751-18752 -LRB- denotes (
T6520 18752-18759 NNP denotes Shandon
T6521 18760-18762 NNP denotes II
T6522 18762-18763 , denotes ,
T6523 18764-18771 NNP denotes Shandon
T6524 18771-18772 , denotes ,
T6525 18773-18780 NNP denotes Runcorn
T6526 18780-18781 , denotes ,
T6527 18782-18784 NNP denotes UK
T6528 18784-18785 -RRB- denotes )
T6529 18785-18786 . denotes .
T6530 18787-18792 NNS denotes Cells
T6531 18793-18797 VBD denotes were
T6532 18798-18811 VBN denotes permeabilized
T6533 18811-18812 , denotes ,
T6534 18813-18820 VBN denotes blocked
T6535 18820-18821 , denotes ,
T6536 18822-18825 CC denotes and
T6537 18826-18830 RB denotes then
T6538 18831-18840 VBN denotes incubated
T6539 18841-18845 IN denotes with
T6540 18846-18848 NNP denotes GR
T6541 18849-18850 -LRB- denotes (
T6542 18850-18851 CD denotes 1
T6543 18851-18852 CD denotes ∶
T6544 18852-18854 CD denotes 50
T6545 18855-18859 NN denotes E-20
T6546 18860-18865 NNP denotes Santa
T6547 18866-18870 NNP denotes Cruz
T6548 18871-18884 NNP denotes Biotechnology
T6549 18884-18885 -RRB- denotes )
T6550 18886-18888 CC denotes or
T6551 18889-18900 JJ denotes anti-GATA-3
T6552 18901-18902 -LRB- denotes (
T6553 18902-18906 JJ denotes H-48
T6554 18906-18907 : denotes ;
T6555 18908-18913 NNP denotes Santa
T6556 18914-18918 NNP denotes Cruz
T6557 18919-18932 NNP denotes Biotechnology
T6558 18932-18933 -RRB- denotes )
T6559 18934-18942 NN denotes antibody
T6560 18943-18946 IN denotes for
T6561 18947-18948 CD denotes 1
T6562 18949-18950 NN denotes h
T6563 18951-18953 IN denotes at
T6564 18954-18958 NN denotes room
T6565 18959-18970 NN denotes temperature
T6566 18970-18971 . denotes .
T6567 18972-18977 IN denotes After
T6568 18978-18983 CD denotes three
T6569 18984-18990 NNS denotes washes
T6570 18991-18993 IN denotes in
T6571 18994-19012 JJ denotes phosphate-buffered
T6572 19013-19019 NN denotes saline
T6573 19020-19021 -LRB- denotes (
T6574 19021-19024 NNP denotes PBS
T6575 19024-19025 -RRB- denotes )
T6576 19025-19026 , denotes ,
T6577 19027-19032 NNS denotes cells
T6578 19033-19037 VBD denotes were
T6579 19038-19047 VBN denotes incubated
T6580 19048-19052 IN denotes with
T6581 19053-19067 JJ denotes tetrarhodamine
T6582 19068-19082 NN denotes isothiocyanate
T6583 19083-19093 VBN denotes conjugated
T6584 19094-19098 NN denotes goat
T6585 19099-19110 JJ denotes anti-rabbit
T6586 19111-19119 NN denotes antibody
T6587 19120-19121 -LRB- denotes (
T6588 19121-19125 NNP denotes Dako
T6589 19125-19126 -RRB- denotes )
T6590 19126-19127 . denotes .
T6591 19128-19137 NNS denotes Cytospins
T6592 19138-19142 VBD denotes were
T6593 19143-19157 VBN denotes counterstained
T6594 19158-19162 IN denotes with
T6595 19163-19164 CD denotes 4
T6596 19164-19165 CD denotes ′
T6597 19165-19167 SYM denotes ,6
T6598 19167-19168 : denotes -
T6599 19168-19192 JJ denotes diamidino-2-phenylindole
T6600 19193-19208 NN denotes dihydrochloride
T6601 19209-19210 -LRB- denotes (
T6602 19210-19214 NNP denotes DAPI
T6603 19214-19215 -RRB- denotes )
T6604 19215-19216 , denotes ,
T6605 19217-19218 DT denotes a
T6606 19219-19230 JJ denotes fluorescent
T6607 19231-19235 JJ denotes blue
T6608 19236-19243 JJ denotes nuclear
T6609 19244-19250 NN denotes indole
T6610 19251-19260 NN denotes chromatin
T6611 19261-19266 VBP denotes stain
T6612 19266-19267 , denotes ,
T6613 19268-19271 CC denotes and
T6614 19272-19279 VBD denotes mounted
T6615 19280-19282 IN denotes in
T6616 19283-19286 NNP denotes PBS
T6617 19286-19287 : denotes :
T6618 19287-19295 NN denotes glycerol
T6619 19296-19297 -LRB- denotes (
T6620 19297-19299 CD denotes 50
T6621 19299-19300 NN denotes ∶
T6622 19300-19302 CD denotes 50
T6623 19302-19303 -RRB- denotes )
T6624 19303-19304 . denotes .
T6625 19305-19308 DT denotes The
T6626 19309-19323 JJ denotes immunopositive
T6627 19324-19330 NN denotes signal
T6628 19331-19334 VBD denotes was
T6629 19335-19348 VBN denotes characterised
T6630 19349-19354 VBG denotes using
T6631 19355-19360 NN denotes laser
T6632 19361-19369 VBG denotes scanning
T6633 19370-19378 JJ denotes confocal
T6634 19379-19389 NN denotes microscopy
T6635 19390-19392 IN denotes on
T6636 19393-19394 DT denotes a
T6637 19395-19400 NNP denotes Leica
T6638 19401-19404 NNP denotes TCS
T6639 19405-19410 NNP denotes NT/SP
T6640 19411-19422 JJ denotes interactive
T6641 19423-19428 NN denotes laser
T6642 19429-19438 NN denotes cytometer
T6643 19439-19447 VBN denotes equipped
T6644 19448-19452 IN denotes with
T6645 19453-19461 JJ denotes confocal
T6646 19462-19468 NNS denotes optics
T6647 19469-19470 -LRB- denotes (
T6648 19470-19475 NNP denotes Leica
T6649 19476-19488 NNP denotes Microsystems
T6650 19488-19489 , denotes ,
T6651 19490-19497 NNP denotes Wetzlar
T6652 19497-19498 , denotes ,
T6653 19499-19506 NNP denotes Germany
T6654 19506-19507 -RRB- denotes )
T6655 19507-19508 . denotes .
T6656 19509-19511 TO denotes To
T6657 19512-19521 VB denotes determine
T6658 19522-19525 DT denotes the
T6659 19526-19537 NN denotes specificity
T6660 19538-19540 IN denotes of
T6661 19541-19544 DT denotes the
T6662 19545-19555 NNS denotes antibodies
T6663 19555-19556 , denotes ,
T6664 19557-19563 NN denotes rabbit
T6665 19564-19569 NN denotes serum
T6666 19570-19584 NN denotes immunoglobulin
T6667 19585-19586 -LRB- denotes (
T6668 19586-19590 NNP denotes Dako
T6669 19590-19591 -RRB- denotes )
T6670 19592-19595 CC denotes and
T6671 19596-19605 JJ denotes secondary
T6672 19606-19616 NNS denotes antibodies
T6673 19617-19624 IN denotes without
T6674 19625-19628 DT denotes the
T6675 19629-19636 JJ denotes primary
T6676 19637-19641 VBD denotes were
T6677 19642-19646 VBN denotes used
T6678 19647-19649 IN denotes as
T6679 19650-19658 NNS denotes controls
T6680 19658-19659 . denotes .
T6681 19660-19670 RB denotes Positively
T6682 19671-19678 VBN denotes stained
T6683 19679-19685 NNS denotes nuclei
T6684 19686-19689 CC denotes and
T6685 19690-19695 JJ denotes total
T6686 19696-19701 NNS denotes cells
T6687 19702-19706 VBD denotes were
T6688 19707-19714 VBN denotes counted
T6689 19715-19716 -LRB- denotes (
T6690 19716-19719 CD denotes 500
T6691 19719-19720 -RRB- denotes )
T6692 19721-19723 IN denotes on
T6693 19724-19728 DT denotes each
T6694 19729-19734 NN denotes slide
T6695 19735-19739 IN denotes with
T6696 19740-19743 DT denotes the
T6697 19744-19752 NN denotes observer
T6698 19753-19760 VBD denotes blinded
T6699 19761-19763 TO denotes to
T6700 19764-19767 DT denotes the
T6701 19768-19777 NN denotes treatment
T6702 19777-19778 . denotes .
T6937 19780-19790 NNP denotes GATA-3-GFP
T6938 19791-19800 NNP denotes Construct
T6939 19801-19804 NNP denotes The
T6940 19805-19811 NNP denotes GATA-3
T6941 19812-19817 NN denotes clone
T6942 19818-19819 -LRB- denotes (
T6943 19819-19827 NNP denotes BC003070
T6944 19827-19828 -RRB- denotes )
T6945 19829-19837 JJ denotes complete
T6946 19838-19842 NNP denotes cDNA
T6947 19843-19846 VBD denotes was
T6948 19847-19855 VBN denotes obtained
T6949 19856-19860 IN denotes from
T6950 19861-19871 NNP denotes Invitrogen
T6951 19872-19876 NNP denotes Life
T6952 19877-19889 NNPS denotes Technologies
T6953 19890-19892 IN denotes as
T6954 19893-19894 DT denotes a
T6955 19895-19896 CD denotes 5
T6956 19896-19897 SYM denotes ′
T6957 19897-19898 : denotes -
T6958 19899-19906 JJ denotes EcoRI/3
T6959 19906-19907 SYM denotes ′
T6960 19907-19908 : denotes -
T6961 19908-19912 NNP denotes XhoI
T6962 19913-19919 NN denotes insert
T6963 19920-19922 IN denotes of
T6964 19923-19929 NN denotes GATA-3
T6965 19930-19932 IN denotes in
T6966 19933-19936 DT denotes the
T6967 19937-19942 NNP denotes pOTB7
T6968 19943-19949 NN denotes vector
T6969 19949-19950 . denotes .
T6970 19951-19957 NN denotes GATA-3
T6971 19958-19961 VBD denotes was
T6972 19962-19969 VBN denotes excised
T6973 19970-19974 IN denotes from
T6974 19975-19980 NNP denotes pOTB7
T6975 19981-19986 VBG denotes using
T6976 19987-19991 NNP denotes XhoI
T6977 19992-20001 NN denotes digestion
T6978 20002-20005 CC denotes and
T6979 20006-20014 NN denotes pEGFP-C2
T6980 20015-20016 -LRB- denotes (
T6981 20016-20024 NNP denotes Clontech
T6982 20024-20025 , denotes ,
T6983 20026-20047 NNP denotes Saint-Germain-en-Laye
T6984 20047-20048 , denotes ,
T6985 20049-20055 NNP denotes France
T6986 20055-20056 -RRB- denotes )
T6987 20057-20060 VBD denotes was
T6988 20061-20069 VBN denotes digested
T6989 20070-20074 IN denotes with
T6990 20075-20080 NNP denotes BamHI
T6991 20080-20081 . denotes .
T6992 20082-20085 NNP denotes DNA
T6993 20086-20089 VBD denotes was
T6994 20090-20099 VBN denotes recovered
T6995 20100-20102 IN denotes by
T6996 20103-20109 NN denotes phenol
T6997 20110-20120 NN denotes extraction
T6998 20121-20124 CC denotes and
T6999 20125-20132 NN denotes ethanol
T7000 20133-20146 NN denotes precipitation
T7001 20146-20147 , denotes ,
T7002 20148-20151 CC denotes and
T7003 20152-20156 DT denotes both
T7004 20157-20160 DT denotes the
T7005 20161-20167 NNP denotes GATA-3
T7006 20168-20176 NN denotes fragment
T7007 20177-20180 CC denotes and
T7008 20181-20184 DT denotes the
T7009 20185-20193 NN denotes pEGFP-C2
T7010 20194-20200 NN denotes vector
T7011 20201-20212 JJ denotes blunt-ended
T7012 20213-20215 IN denotes by
T7013 20216-20226 NN denotes incubation
T7014 20227-20231 IN denotes with
T7015 20232-20238 NNP denotes Klenow
T7016 20239-20240 -LRB- denotes (
T7017 20240-20247 NNP denotes Bioline
T7018 20248-20257 NNP denotes Bio-27029
T7019 20257-20258 -RRB- denotes )
T7020 20259-20262 IN denotes for
T7021 20263-20265 CD denotes 30
T7022 20266-20269 NN denotes min
T7023 20270-20272 IN denotes at
T7024 20273-20275 CD denotes 37
T7025 20275-20276 CD denotes °
T7026 20276-20278 NNP denotes C.
T7027 20279-20285 NNP denotes Klenow
T7028 20286-20289 VBD denotes was
T7029 20290-20301 VBN denotes inactivated
T7030 20302-20304 IN denotes by
T7031 20305-20315 NN denotes incubation
T7032 20316-20319 IN denotes for
T7033 20320-20322 CD denotes 10
T7034 20323-20326 NN denotes min
T7035 20327-20329 IN denotes at
T7036 20330-20332 CD denotes 75
T7037 20332-20333 CD denotes °
T7038 20333-20335 NNP denotes C.
T7039 20336-20339 NNP denotes DNA
T7040 20340-20343 VBD denotes was
T7041 20344-20353 VBN denotes recovered
T7042 20354-20356 IN denotes by
T7043 20357-20363 NN denotes phenol
T7044 20364-20374 NN denotes extraction
T7045 20375-20378 CC denotes and
T7046 20379-20386 NN denotes ethanol
T7047 20387-20400 NN denotes precipitation
T7048 20400-20401 , denotes ,
T7049 20402-20405 CC denotes and
T7050 20406-20410 DT denotes both
T7051 20411-20414 DT denotes the
T7052 20415-20426 JJ denotes blunt-ended
T7053 20427-20433 JJ denotes GATA-3
T7054 20434-20442 NN denotes fragment
T7055 20443-20446 CC denotes and
T7056 20447-20450 DT denotes the
T7057 20451-20454 NNP denotes GFP
T7058 20455-20461 NN denotes vector
T7059 20462-20466 VBD denotes were
T7060 20467-20479 RB denotes subsequently
T7061 20480-20488 VBN denotes digested
T7062 20489-20493 IN denotes with
T7063 20494-20499 NNP denotes EcoRI
T7064 20500-20506 IN denotes before
T7065 20507-20510 DT denotes the
T7066 20511-20512 CD denotes 5
T7067 20512-20513 SYM denotes ′
T7068 20513-20514 : denotes -
T7069 20514-20521 JJ denotes EcoRI/3
T7070 20521-20522 NN denotes ′
T7071 20523-20528 JJ denotes blunt
T7072 20529-20532 NN denotes end
T7073 20533-20539 NN denotes GATA-3
T7074 20540-20548 NN denotes fragment
T7075 20549-20552 VBD denotes was
T7076 20553-20561 VBN denotes inserted
T7077 20562-20566 IN denotes into
T7078 20567-20570 DT denotes the
T7079 20571-20572 CD denotes 5
T7080 20572-20573 SYM denotes ′
T7081 20573-20574 : denotes -
T7082 20574-20581 JJ denotes EcoRI/3
T7083 20581-20582 NN denotes ′
T7084 20583-20588 JJ denotes blunt
T7085 20589-20594 VBN denotes ended
T7086 20595-20598 NNP denotes GFP
T7087 20599-20605 NN denotes vector
T7088 20605-20606 . denotes .
T7089 20607-20615 JJ denotes Positive
T7090 20616-20622 NNS denotes clones
T7091 20623-20627 VBD denotes were
T7092 20628-20637 VBN denotes confirmed
T7093 20638-20640 IN denotes by
T7094 20641-20650 NN denotes digestion
T7095 20651-20654 CC denotes and
T7096 20655-20659 NN denotes size
T7097 20660-20668 NN denotes analysis
T7098 20669-20671 IN denotes by
T7099 20672-20673 CD denotes 1
T7100 20673-20674 NN denotes %
T7101 20675-20682 JJ denotes agarose
T7102 20683-20686 NN denotes gel
T7103 20687-20702 NN denotes electrophoresis
T7104 20703-20706 CC denotes and
T7105 20707-20709 IN denotes by
T7106 20710-20720 VBG denotes sequencing
T7107 20720-20721 . denotes .
T7254 20723-20735 NNP denotes Transfection
T7255 20736-20742 NNP denotes HuT-78
T7256 20743-20748 NNS denotes cells
T7257 20749-20753 VBD denotes were
T7258 20754-20765 VBN denotes transfected
T7259 20766-20770 IN denotes with
T7260 20771-20777 DT denotes either
T7261 20778-20781 CD denotes EP8
T7262 20782-20784 CC denotes or
T7263 20785-20788 NNP denotes GFP
T7264 20789-20795 NN denotes vector
T7265 20796-20800 RB denotes only
T7266 20801-20804 NNP denotes DNA
T7267 20805-20810 VBG denotes using
T7268 20811-20819 NN denotes solution
T7269 20820-20821 NN denotes R
T7270 20821-20822 , denotes ,
T7271 20823-20832 NN denotes programme
T7272 20833-20838 NN denotes V-001
T7273 20839-20841 IN denotes at
T7274 20842-20843 DT denotes a
T7275 20844-20849 NN denotes ratio
T7276 20850-20852 IN denotes of
T7277 20853-20854 CD denotes 3
T7278 20854-20855 CD denotes ×
T7279 20855-20858 CD denotes 106
T7280 20859-20866 CD denotes cells/4
T7281 20867-20869 NN denotes µg
T7282 20870-20873 NN denotes DNA
T7283 20874-20877 IN denotes for
T7284 20878-20879 CD denotes 7
T7285 20880-20881 CD denotes 8
T7286 20882-20883 NN denotes h
T7287 20884-20886 IN denotes in
T7288 20887-20895 JJ denotes complete
T7289 20896-20902 NN denotes medium
T7290 20903-20904 -LRB- denotes (
T7291 20904-20906 CD denotes 10
T7292 20906-20907 NN denotes %
T7293 20908-20914 JJ denotes bovine
T7294 20915-20920 NN denotes serum
T7295 20921-20923 IN denotes in
T7296 20924-20932 NNP denotes RPMI1640
T7297 20932-20935 CD denotes +15
T7298 20936-20947 NN denotes L-glutamine
T7299 20947-20948 -RRB- denotes )
T7300 20949-20958 VBG denotes according
T7301 20959-20961 TO denotes to
T7302 20962-20965 DT denotes the
T7303 20966-20973 JJ denotes general
T7304 20974-20979 NNP denotes Amaxa
T7305 20980-20988 NN denotes protocol
T7306 20989-20992 IN denotes for
T7307 20993-21006 NN denotes nucleofection
T7308 21006-21007 . denotes .
T7309 21008-21011 DT denotes The
T7310 21012-21018 NN denotes medium
T7311 21019-21022 VBD denotes was
T7312 21023-21035 RB denotes subsequently
T7313 21036-21043 VBN denotes changed
T7314 21044-21046 TO denotes to
T7315 21047-21048 CD denotes 1
T7316 21048-21049 NN denotes %
T7317 21050-21054 NNP denotes RPMI
T7318 21055-21058 IN denotes for
T7319 21059-21061 CD denotes 24
T7320 21062-21063 NN denotes h
T7321 21064-21070 IN denotes before
T7322 21071-21082 VBN denotes transfected
T7323 21083-21088 NNS denotes cells
T7324 21089-21093 VBD denotes were
T7325 21094-21099 VBN denotes added
T7326 21100-21102 TO denotes to
T7327 21103-21111 JJ denotes anti-CD3
T7328 21111-21112 NN denotes /
T7329 21112-21116 CD denotes CD28
T7330 21117-21124 VBN denotes treated
T7331 21125-21130 NNS denotes wells
T7332 21131-21134 CC denotes and
T7333 21135-21139 VBP denotes live
T7334 21140-21144 NN denotes cell
T7335 21145-21160 JJ denotes videomicroscopy
T7336 21161-21170 VBN denotes performed
T7337 21170-21171 . denotes .
T7473 21173-21183 NNP denotes Time-Lapse
T7474 21184-21194 NNP denotes Microscopy
T7475 21195-21201 NNP denotes HuT-78
T7476 21202-21207 NNS denotes cells
T7477 21208-21218 VBG denotes expressing
T7478 21219-21229 NNP denotes GATA-3-GFP
T7479 21230-21234 VBD denotes were
T7480 21235-21245 VBN denotes maintained
T7481 21246-21248 IN denotes at
T7482 21249-21251 CD denotes 37
T7483 21251-21252 CD denotes °
T7484 21252-21253 NNP denotes C
T7485 21254-21256 IN denotes in
T7486 21257-21263 NN denotes growth
T7487 21264-21270 NN denotes medium
T7488 21271-21273 IN denotes in
T7489 21274-21275 DT denotes a
T7490 21276-21282 JJ denotes closed
T7491 21283-21287 CD denotes FCS2
T7492 21288-21297 NN denotes perfusion
T7493 21298-21305 NN denotes chamber
T7494 21306-21307 -LRB- denotes (
T7495 21307-21316 NNPS denotes Bioptechs
T7496 21316-21317 , denotes ,
T7497 21318-21324 NNP denotes Butler
T7498 21324-21325 , denotes ,
T7499 21326-21338 NNP denotes Pennsylvania
T7500 21338-21339 , denotes ,
T7501 21340-21343 NNP denotes USA
T7502 21343-21344 -RRB- denotes )
T7503 21345-21353 VBN denotes combined
T7504 21354-21358 IN denotes with
T7505 21359-21361 DT denotes an
T7506 21362-21371 JJ denotes objective
T7507 21372-21378 NN denotes heater
T7508 21379-21380 -LRB- denotes (
T7509 21380-21389 NNPS denotes Bioptechs
T7510 21389-21390 -RRB- denotes )
T7511 21391-21393 IN denotes on
T7512 21394-21397 DT denotes the
T7513 21398-21403 NN denotes stage
T7514 21404-21405 DT denotes a
T7515 21406-21411 NNP denotes Zeiss
T7516 21412-21420 NNP denotes Axiovert
T7517 21421-21424 CD denotes 200
T7518 21425-21435 NN denotes microscope
T7519 21436-21437 -LRB- denotes (
T7520 21437-21446 NNP denotes Thornwood
T7521 21446-21447 , denotes ,
T7522 21448-21451 NNP denotes New
T7523 21452-21456 NNP denotes York
T7524 21456-21457 , denotes ,
T7525 21458-21461 NNP denotes USA
T7526 21461-21462 -RRB- denotes )
T7527 21462-21463 . denotes .
T7528 21464-21476 NNS denotes Observations
T7529 21477-21481 VBD denotes were
T7530 21482-21486 VBN denotes made
T7531 21487-21489 IN denotes by
T7532 21490-21492 CD denotes 40
T7533 21492-21493 CD denotes ×
T7534 21493-21496 CD denotes 1.0
T7535 21497-21499 NNP denotes NA
T7536 21500-21513 NN denotes oil-immersion
T7537 21514-21523 NN denotes objective
T7538 21524-21528 NN denotes lens
T7539 21528-21529 , denotes ,
T7540 21530-21533 CC denotes and
T7541 21534-21546 NN denotes fluorescence
T7542 21547-21550 CC denotes and
T7543 21551-21556 NN denotes phase
T7544 21557-21565 NN denotes contrast
T7545 21566-21572 NNS denotes images
T7546 21573-21577 VBD denotes were
T7547 21578-21586 VBN denotes gathered
T7548 21587-21592 VBG denotes using
T7549 21593-21594 DT denotes a
T7550 21595-21604 NNP denotes Hamamatsu
T7551 21605-21612 NNP denotes ORCA-ER
T7552 21613-21620 VBD denotes charged
T7553 21621-21628 VBN denotes coupled
T7554 21629-21635 NN denotes device
T7555 21636-21642 NN denotes camera
T7556 21643-21644 -LRB- denotes (
T7557 21644-21655 NNP denotes Bridgewater
T7558 21655-21656 , denotes ,
T7559 21657-21660 NNP denotes New
T7560 21661-21667 NNP denotes Jersey
T7561 21667-21668 , denotes ,
T7562 21669-21672 NNP denotes USA
T7563 21672-21673 -RRB- denotes )
T7564 21674-21680 VBN denotes driven
T7565 21681-21683 IN denotes by
T7566 21684-21691 NNP denotes Openlab
T7567 21692-21700 NN denotes software
T7568 21701-21702 -LRB- denotes (
T7569 21702-21713 NNP denotes Improvision
T7570 21713-21714 , denotes ,
T7571 21715-21723 NNP denotes Coventry
T7572 21723-21724 , denotes ,
T7573 21725-21727 NNP denotes UK
T7574 21727-21728 -RRB- denotes )
T7575 21728-21729 . denotes .
T7576 21730-21741 NNS denotes Photographs
T7577 21742-21746 VBD denotes were
T7578 21747-21752 VBN denotes taken
T7579 21753-21755 IN denotes at
T7580 21756-21757 CD denotes 0
T7581 21757-21758 , denotes ,
T7582 21759-21761 CD denotes 30
T7583 21761-21762 , denotes ,
T7584 21763-21765 CD denotes 60
T7585 21765-21766 , denotes ,
T7586 21767-21770 CD denotes 120
T7587 21770-21771 , denotes ,
T7588 21772-21775 CC denotes and
T7589 21776-21779 CD denotes 240
T7590 21780-21783 NN denotes min
T7591 21783-21784 . denotes .
T7691 21786-21799 NNP denotes Densitometric
T7692 21800-21808 NNP denotes Analysis
T7693 21809-21821 NNP denotes Densitometry
T7694 21822-21824 IN denotes of
T7695 21825-21828 NNP denotes ECL
T7696 21829-21840 NNS denotes immunoblots
T7697 21841-21844 VBD denotes was
T7698 21845-21854 VBN denotes performed
T7699 21855-21860 VBG denotes using
T7700 21861-21869 NNP denotes Gelworks
T7701 21870-21872 NNP denotes ID
T7702 21873-21885 JJ denotes intermediate
T7703 21886-21894 NN denotes software
T7704 21895-21896 -LRB- denotes (
T7705 21896-21907 NNP denotes Ultraviolet
T7706 21908-21916 NNPS denotes Products
T7707 21916-21917 , denotes ,
T7708 21918-21932 NNP denotes Cambridgeshire
T7709 21932-21933 , denotes ,
T7710 21934-21936 NNP denotes UK
T7711 21936-21937 -RRB- denotes )
T7712 21937-21938 . denotes .
T7713 21939-21946 RB denotes Briefly
T7714 21946-21947 , denotes ,
T7715 21948-21959 NNS denotes immunoblots
T7716 21960-21964 VBD denotes were
T7717 21965-21972 VBN denotes scanned
T7718 21973-21976 CC denotes and
T7719 21977-21982 NNS denotes gates
T7720 21983-21987 VBD denotes were
T7721 21988-21993 VBN denotes drawn
T7722 21994-22001 RB denotes tightly
T7723 22002-22008 IN denotes around
T7724 22009-22013 DT denotes each
T7725 22014-22018 NN denotes band
T7726 22018-22019 . denotes .
T7727 22020-22030 NN denotes Background
T7728 22031-22037 NNS denotes values
T7729 22038-22042 IN denotes from
T7730 22043-22047 DT denotes each
T7731 22048-22052 NN denotes lane
T7732 22053-22057 VBD denotes were
T7733 22058-22068 VBN denotes subtracted
T7734 22069-22071 TO denotes to
T7735 22072-22081 VB denotes normalize
T7736 22082-22086 DT denotes each
T7737 22087-22098 NN denotes measurement
T7738 22098-22099 . denotes .
T7739 22100-22103 DT denotes The
T7740 22104-22109 NNS denotes bands
T7741 22110-22114 VBD denotes were
T7742 22115-22125 VBN denotes quantified
T7743 22126-22131 VBG denotes using
T7744 22132-22135 DT denotes the
T7745 22136-22144 NNPS denotes Gelworks
T7746 22145-22153 NN denotes software
T7747 22153-22154 . denotes .
T7748 22155-22158 DT denotes All
T7749 22159-22166 JJ denotes Western
T7750 22167-22172 NNS denotes blots
T7751 22173-22177 VBD denotes were
T7752 22178-22185 VBN denotes exposed
T7753 22186-22188 TO denotes to
T7754 22189-22193 NN denotes film
T7755 22194-22197 IN denotes for
T7756 22198-22205 VBG denotes varying
T7757 22206-22213 NNS denotes lengths
T7758 22214-22216 IN denotes of
T7759 22217-22221 NN denotes time
T7760 22221-22222 , denotes ,
T7761 22223-22226 CC denotes and
T7762 22227-22231 RB denotes only
T7763 22232-22237 NNS denotes films
T7764 22238-22248 VBG denotes generating
T7765 22249-22262 JJ denotes subsaturating
T7766 22263-22269 NNS denotes levels
T7767 22270-22272 IN denotes of
T7768 22273-22282 NN denotes intensity
T7769 22283-22287 VBD denotes were
T7770 22288-22296 VBN denotes selected
T7771 22297-22300 IN denotes for
T7772 22301-22314 JJ denotes densitometric
T7773 22315-22325 NN denotes evaluation
T7774 22325-22326 . denotes .
T7934 22328-22339 NNP denotes Statistical
T7935 22340-22348 NNP denotes Analysis
T7936 22349-22353 NNP denotes Data
T7937 22354-22358 IN denotes from
T7938 22359-22364 CD denotes three
T7939 22365-22367 CC denotes or
T7940 22368-22372 JJR denotes more
T7941 22373-22384 JJ denotes independent
T7942 22385-22396 NNS denotes experiments
T7943 22397-22400 VBP denotes are
T7944 22401-22410 VBN denotes presented
T7945 22411-22413 IN denotes as
T7946 22414-22417 DT denotes the
T7947 22418-22422 JJ denotes mean
T7948 22422-22423 NN denotes ±
T7949 22423-22431 NN denotes standard
T7950 22432-22437 NN denotes error
T7951 22438-22440 IN denotes of
T7952 22441-22444 DT denotes the
T7953 22445-22449 NN denotes mean
T7954 22450-22451 -LRB- denotes (
T7955 22451-22454 NNP denotes SEM
T7956 22454-22455 -RRB- denotes )
T7957 22455-22456 , denotes ,
T7958 22457-22463 IN denotes except
T7959 22464-22469 WRB denotes where
T7960 22470-22476 VBN denotes stated
T7961 22477-22480 CC denotes and
T7962 22481-22485 VBD denotes were
T7963 22486-22494 VBN denotes compared
T7964 22495-22500 VBG denotes using
T7965 22501-22509 NNP denotes GraphPad
T7966 22510-22515 NNP denotes Prism
T7967 22516-22517 CD denotes 4
T7968 22518-22519 -LRB- denotes (
T7969 22519-22527 NNP denotes GraphPad
T7970 22528-22536 NNP denotes Software
T7971 22536-22537 , denotes ,
T7972 22538-22561 NN denotes http://www.graphpad.com
T7973 22561-22562 -RRB- denotes )
T7974 22562-22563 . denotes .
T7975 22564-22571 NNS denotes Results
T7976 22572-22576 VBD denotes were
T7977 22577-22585 JJ denotes analysed
T7978 22586-22591 VBG denotes using
T7979 22592-22599 JJ denotes one-way
T7980 22600-22605 NNP denotes ANOVA
T7981 22606-22610 IN denotes with
T7982 22611-22623 NNP denotes Newman-Keuls
T7983 22624-22628 NN denotes post
T7984 22629-22633 NN denotes test
T7985 22634-22640 IN denotes except
T7986 22641-22644 IN denotes for
T7987 22645-22648 DT denotes the
T7988 22649-22653 NNS denotes data
T7989 22654-22658 IN denotes from
T7990 22659-22662 DT denotes the
T7991 22663-22665 IN denotes in
T7992 22666-22670 NN denotes vivo
T7993 22671-22678 VBD denotes inhaled
T7994 22679-22681 NNP denotes FP
T7995 22682-22687 NN denotes study
T7996 22687-22688 , denotes ,
T7997 22689-22694 WDT denotes which
T7998 22695-22698 VBD denotes was
T7999 22699-22707 VBN denotes analysed
T8000 22708-22710 IN denotes by
T8001 22711-22719 NNP denotes Friedman
T8002 22719-22721 POS denotes 's
T8003 22722-22726 NN denotes test
T8004 22727-22731 IN denotes with
T8005 22732-22742 JJ denotes subsequent
T8006 22743-22752 NNP denotes Wilcoxson
T8007 22753-22760 VBD denotes matched
T8008 22761-22765 NN denotes pair
T8009 22766-22772 VBD denotes signed
T8010 22773-22777 NN denotes rank
T8011 22778-22781 NN denotes sum
T8012 22782-22786 NN denotes test
T8013 22786-22787 . denotes .
T8014 22788-22792 NNP denotes Data
T8015 22793-22797 IN denotes from
T8016 22798-22802 DT denotes this
T8017 22803-22811 NN denotes analysis
T8018 22812-22815 VBP denotes are
T8019 22816-22825 VBN denotes presented
T8020 22826-22828 IN denotes as
T8021 22829-22830 DT denotes a
T8022 22831-22847 NNS denotes box-and-whiskers
T8023 22848-22852 NN denotes plot
T8024 22852-22853 . denotes .
T8025 22854-22862 NNP denotes Friedman
T8026 22862-22864 POS denotes 's
T8027 22865-22869 NN denotes test
T8028 22870-22873 VBD denotes was
T8029 22874-22878 VBN denotes used
T8030 22879-22881 IN denotes as
T8031 22882-22887 CD denotes three
T8032 22888-22895 VBN denotes matched
T8033 22896-22904 NNS denotes measures
T8034 22905-22909 VBD denotes were
T8035 22910-22918 VBN denotes obtained
T8036 22919-22924 VBG denotes using
T8037 22925-22932 NN denotes placebo
T8038 22932-22933 , denotes ,
T8039 22934-22937 CD denotes 100
T8040 22938-22940 NN denotes µg
T8041 22940-22941 , denotes ,
T8042 22942-22945 CC denotes and
T8043 22946-22949 CD denotes 500
T8044 22950-22952 NN denotes µg
T8045 22953-22955 IN denotes of
T8046 22956-22963 JJ denotes inhaled
T8047 22964-22966 NNP denotes FP
T8048 22966-22967 , denotes ,
T8049 22968-22973 WDT denotes which
T8050 22974-22977 VBD denotes had
T8051 22978-22986 JJ denotes variable
T8052 22987-22995 NN denotes baseline
T8053 22996-23002 NNS denotes levels
T8054 23002-23003 . denotes .
T8055 23004-23006 PRP denotes We
T8056 23007-23010 VBD denotes did
T8057 23011-23014 RB denotes not
T8058 23015-23021 VB denotes assume
T8059 23022-23023 DT denotes a
T8060 23024-23032 JJ denotes Gaussian
T8061 23033-23045 NN denotes distribution
T8062 23046-23048 IN denotes of
T8063 23049-23052 DT denotes the
T8064 23053-23057 NNS denotes data
T8065 23058-23061 JJ denotes due
T8066 23062-23064 TO denotes to
T8067 23065-23068 DT denotes the
T8068 23069-23076 JJ denotes limited
T8069 23077-23084 NNS denotes numbers
T8070 23085-23087 IN denotes of
T8071 23088-23100 NNS denotes participants
T8072 23101-23109 VBN denotes analysed
T8073 23110-23111 -LRB- denotes (
T8074 23111-23116 CD denotes seven
T8075 23116-23117 -RRB- denotes )
T8076 23117-23118 . denotes .
T8077 23118-23121 DT denotes The
T8078 23122-23126 NN denotes null
T8079 23127-23137 NN denotes hypothesis
T8080 23138-23141 VBD denotes was
T8081 23142-23150 VBN denotes rejected
T8082 23151-23153 IN denotes at
T8083 23154-23155 NN denotes p
T8084 23155-23156 NN denotes <
T8085 23156-23160 CD denotes 0.05
T8086 23160-23161 . denotes .
T8451 23172-23175 DT denotes The
T8452 23176-23182 NN denotes Effect
T8453 23183-23185 IN denotes of
T8454 23186-23201 NNS denotes Corticosteroids
T8455 23202-23204 IN denotes on
T8456 23205-23211 NNP denotes GATA-3
T8457 23212-23219 NNP denotes Nuclear
T8458 23220-23233 NNP denotes Translocation
T8459 23234-23237 CC denotes and
T8460 23238-23242 NN denotes IL-4
T8461 23243-23247 NNP denotes mRNA
T8462 23248-23263 NNP denotes Corticosteroids
T8463 23264-23267 VBP denotes are
T8464 23268-23277 JJ denotes effective
T8465 23278-23280 IN denotes in
T8466 23281-23291 VBG denotes inhibiting
T8467 23292-23308 JJ denotes GATA-3-regulated
T8468 23309-23313 NN denotes IL-4
T8469 23314-23318 NN denotes gene
T8470 23319-23329 NN denotes expression
T8471 23330-23332 IN denotes in
T8472 23333-23338 NN denotes vitro
T8473 23339-23342 CC denotes and
T8474 23343-23345 IN denotes in
T8475 23346-23350 NN denotes vivo
T8476 23351-23352 NNP denotes [
T8477 23352-23354 CD denotes 32
T8478 23354-23355 NNP denotes ]
T8479 23355-23356 . denotes .
T8480 23357-23359 PRP denotes We
T8481 23360-23369 RB denotes therefore
T8482 23370-23382 VBD denotes investigated
T8483 23383-23390 IN denotes whether
T8484 23391-23406 NNS denotes corticosteroids
T8485 23407-23413 VBP denotes affect
T8486 23414-23422 JJ denotes anti-CD3
T8487 23422-23423 NN denotes /
T8488 23423-23427 CD denotes CD28
T8489 23428-23438 VBD denotes stimulated
T8490 23439-23446 JJ denotes nuclear
T8491 23447-23453 NN denotes import
T8492 23454-23456 IN denotes of
T8493 23457-23463 NN denotes GATA-3
T8494 23463-23464 . denotes .
T8495 23465-23476 NN denotes Stimulation
T8496 23477-23479 IN denotes of
T8497 23480-23485 NNS denotes cells
T8498 23486-23490 IN denotes with
T8499 23491-23499 JJ denotes anti-CD3
T8500 23499-23500 NN denotes /
T8501 23500-23504 CD denotes CD28
T8502 23505-23513 VBD denotes resulted
T8503 23514-23516 IN denotes in
T8504 23517-23518 DT denotes a
T8505 23519-23524 JJ denotes rapid
T8506 23525-23544 NN denotes cytoplasmic/nuclear
T8507 23545-23551 NN denotes GATA-3
T8508 23552-23565 NN denotes translocation
T8509 23566-23567 -LRB- denotes (
T8510 23567-23573 NN denotes Figure
T8511 23574-23576 CD denotes 1A
T8512 23576-23577 -RRB- denotes )
T8513 23577-23578 , denotes ,
T8514 23579-23589 VBG denotes confirming
T8515 23590-23593 PRP$ denotes our
T8516 23594-23602 JJ denotes previous
T8517 23603-23610 NNS denotes results
T8518 23611-23612 NNP denotes [
T8519 23612-23614 CD denotes 12
T8520 23614-23615 NNP denotes ]
T8521 23615-23616 . denotes .
T8522 23617-23619 PRP denotes We
T8523 23620-23624 RB denotes also
T8524 23625-23634 VBD denotes confirmed
T8525 23635-23636 DT denotes a
T8526 23637-23642 JJ denotes clear
T8527 23643-23653 NN denotes separation
T8528 23654-23656 IN denotes of
T8529 23657-23664 JJ denotes nuclear
T8530 23665-23668 CC denotes and
T8531 23669-23678 JJ denotes cytosolic
T8532 23679-23688 NNS denotes fractions
T8533 23689-23691 IN denotes as
T8534 23692-23701 VBN denotes indicated
T8535 23702-23704 IN denotes by
T8536 23705-23712 NN denotes histone
T8537 23713-23715 CD denotes H1
T8538 23716-23719 CC denotes and
T8539 23720-23725 CD denotes MEK-1
T8540 23726-23733 NNS denotes markers
T8541 23734-23735 -LRB- denotes (
T8542 23735-23741 NN denotes Figure
T8543 23742-23744 NN denotes 1B
T8544 23744-23745 -RRB- denotes )
T8545 23745-23746 . denotes .
T8546 23747-23750 DT denotes The
T8547 23751-23757 JJ denotes potent
T8548 23758-23765 JJ denotes topical
T8549 23766-23780 JJ denotes corticosteroid
T8550 23781-23783 NN denotes FP
T8551 23784-23790 VBD denotes caused
T8552 23791-23800 JJ denotes sustained
T8553 23801-23805 NN denotes loss
T8554 23806-23808 IN denotes of
T8555 23809-23816 JJ denotes nuclear
T8556 23817-23823 JJ denotes GATA-3
T8557 23824-23834 NN denotes expression
T8558 23835-23838 CC denotes and
T8559 23839-23850 JJ denotes cytoplasmic
T8560 23851-23860 NN denotes retention
T8561 23861-23863 IN denotes of
T8562 23864-23870 NN denotes GATA-3
T8563 23871-23873 IN denotes at
T8564 23874-23888 NNS denotes concentrations
T8565 23889-23896 VBG denotes ranging
T8566 23897-23901 IN denotes from
T8567 23902-23904 CD denotes 10
T8568 23904-23905 CD denotes −
T8569 23905-23907 CD denotes 12
T8570 23908-23910 TO denotes to
T8571 23911-23913 CD denotes 10
T8572 23913-23914 CD denotes −
T8573 23914-23915 CD denotes 8
T8574 23916-23917 NNP denotes M
T8575 23917-23918 , denotes ,
T8576 23919-23924 WDT denotes which
T8577 23925-23930 VBP denotes cover
T8578 23931-23934 DT denotes the
T8579 23935-23946 JJ denotes therapeutic
T8580 23947-23952 NN denotes range
T8581 23953-23954 NNP denotes [
T8582 23954-23956 CD denotes 37
T8583 23956-23957 NNP denotes ]
T8584 23957-23958 . denotes .
T8585 23959-23963 DT denotes This
T8586 23964-23970 NN denotes effect
T8587 23971-23974 VBD denotes was
T8588 23975-23988 NN denotes concentration
T8589 23988-23989 : denotes -
T8590 23990-23993 CC denotes and
T8591 23994-24008 JJ denotes time-dependent
T8592 24008-24009 , denotes ,
T8593 24010-24014 IN denotes with
T8594 24015-24016 DT denotes a
T8595 24017-24021 JJ denotes peak
T8596 24022-24028 NN denotes effect
T8597 24029-24031 IN denotes of
T8598 24032-24041 JJ denotes 11.6-fold
T8599 24042-24044 IN denotes at
T8600 24045-24047 CD denotes 30
T8601 24048-24051 NN denotes min
T8602 24052-24054 IN denotes at
T8603 24055-24056 DT denotes a
T8604 24057-24070 NN denotes concentration
T8605 24071-24073 IN denotes of
T8606 24074-24076 CD denotes 10
T8607 24076-24077 NN denotes −
T8608 24077-24078 CD denotes 8
T8609 24079-24080 NNP denotes M
T8610 24081-24082 -LRB- denotes (
T8611 24082-24088 NNP denotes Figure
T8612 24089-24091 NNP denotes 1C
T8613 24091-24092 -RRB- denotes )
T8614 24093-24096 CC denotes and
T8615 24097-24100 VBD denotes was
T8616 24101-24111 VBN denotes associated
T8617 24112-24116 IN denotes with
T8618 24117-24123 JJ denotes marked
T8619 24124-24134 NNS denotes reductions
T8620 24135-24137 IN denotes in
T8621 24138-24146 JJ denotes anti-CD3
T8622 24146-24147 NN denotes /
T8623 24147-24151 CD denotes CD28
T8624 24152-24162 VBD denotes stimulated
T8625 24163-24167 NN denotes IL-4
T8626 24168-24171 CC denotes and
T8627 24172-24176 NN denotes IL-5
T8628 24177-24181 NNP denotes mRNA
T8629 24182-24192 NN denotes expression
T8630 24193-24194 -LRB- denotes (
T8631 24194-24200 NN denotes Figure
T8632 24201-24203 CD denotes 1D
T8633 24203-24204 -RRB- denotes )
T8634 24205-24208 CC denotes and
T8635 24209-24210 DT denotes a
T8636 24211-24215 NN denotes loss
T8637 24216-24218 IN denotes of
T8638 24219-24225 JJ denotes GATA-3
T8639 24226-24233 JJ denotes binding
T8640 24234-24236 TO denotes to
T8641 24237-24240 DT denotes the
T8642 24241-24247 JJ denotes native
T8643 24248-24252 NN denotes IL-5
T8644 24253-24261 NN denotes promoter
T8645 24262-24263 -LRB- denotes (
T8646 24263-24269 NN denotes Figure
T8647 24270-24272 CD denotes 1E
T8648 24272-24273 -RRB- denotes )
T8649 24273-24274 . denotes .
T9109 25824-25840 NNP denotes Ligand-Activated
T9110 25841-25843 NNP denotes GR
T9111 25844-25852 VBZ denotes Competes
T9112 25853-25857 IN denotes with
T9113 25858-25864 NNP denotes GATA-3
T9114 25865-25868 IN denotes for
T9115 25869-25879 NNP denotes Importin-α
T9116 25880-25882 PRP denotes We
T9117 25883-25892 VBD denotes confirmed
T9118 25893-25896 CC denotes and
T9119 25897-25905 VBD denotes extended
T9120 25906-25914 JJ denotes previous
T9121 25915-25919 NNS denotes data
T9122 25920-25921 NNP denotes [
T9123 25921-25923 CD denotes 20
T9124 25923-25924 NNP denotes ]
T9125 25925-25927 TO denotes to
T9126 25928-25932 VB denotes show
T9127 25933-25937 IN denotes that
T9128 25938-25954 JJ denotes ligand-activated
T9129 25955-25957 NNP denotes GR
T9130 25958-25960 RB denotes as
T9131 25961-25965 RB denotes well
T9132 25966-25968 IN denotes as
T9133 25969-25975 JJ denotes GATA-3
T9134 25976-25980 NNS denotes uses
T9135 25981-25991 JJ denotes importin-α
T9136 25992-25995 IN denotes for
T9137 25996-25999 PRP$ denotes its
T9138 26000-26007 JJ denotes nuclear
T9139 26008-26014 NN denotes import
T9140 26015-26016 -LRB- denotes (
T9141 26016-26022 NN denotes Figure
T9142 26023-26025 CD denotes 2A
T9143 26026-26029 CC denotes and
T9144 26030-26032 CD denotes 2B
T9145 26032-26033 -RRB- denotes )
T9146 26033-26034 . denotes .
T9147 26035-26039 DT denotes This
T9148 26040-26051 NN denotes interaction
T9149 26052-26059 IN denotes between
T9150 26060-26062 NNP denotes GR
T9151 26063-26066 CC denotes and
T9152 26067-26077 NNP denotes importin-α
T9153 26078-26081 VBD denotes was
T9154 26082-26093 JJ denotes significant
T9155 26094-26096 IN denotes at
T9156 26097-26111 NNS denotes concentrations
T9157 26112-26114 RB denotes as
T9158 26115-26118 JJ denotes low
T9159 26119-26121 IN denotes as
T9160 26122-26124 CD denotes 10
T9161 26124-26125 CD denotes −
T9162 26125-26127 CD denotes 12
T9163 26128-26129 NNP denotes M
T9164 26130-26133 CC denotes and
T9165 26134-26137 VBD denotes was
T9166 26138-26145 JJ denotes maximal
T9167 26146-26150 IN denotes with
T9168 26151-26153 CD denotes 10
T9169 26153-26154 NN denotes −
T9170 26154-26155 CD denotes 8
T9171 26156-26157 NNP denotes M
T9172 26158-26160 NNP denotes FP
T9173 26160-26161 . denotes .
T9174 26162-26172 JJ denotes Subsequent
T9175 26173-26175 NNP denotes GR
T9176 26176-26183 JJ denotes nuclear
T9177 26184-26197 NN denotes translocation
T9178 26198-26201 VBD denotes was
T9179 26202-26207 JJ denotes rapid
T9180 26208-26211 CC denotes and
T9181 26212-26221 VBD denotes sustained
T9182 26222-26224 IN denotes at
T9183 26225-26236 JJ denotes significant
T9184 26237-26243 NNS denotes levels
T9185 26244-26247 IN denotes for
T9186 26248-26250 IN denotes at
T9187 26251-26256 JJS denotes least
T9188 26257-26259 CD denotes 14
T9189 26260-26261 NN denotes h
T9190 26262-26263 -LRB- denotes (
T9191 26263-26269 NN denotes Figure
T9192 26270-26272 NN denotes 2B
T9193 26272-26273 -RRB- denotes )
T9194 26273-26274 . denotes .
T9195 26275-26280 VBG denotes Using
T9196 26281-26291 JJ denotes IP-Western
T9197 26292-26300 VBG denotes blotting
T9198 26301-26303 PRP denotes we
T9199 26304-26310 VBD denotes showed
T9200 26311-26315 IN denotes that
T9201 26316-26318 NNP denotes FP
T9202 26319-26321 IN denotes at
T9203 26322-26324 CD denotes 10
T9204 26324-26325 CD denotes −
T9205 26325-26327 CD denotes 12
T9206 26328-26330 CD denotes 10
T9207 26330-26331 NN denotes −
T9208 26331-26332 CD denotes 8
T9209 26333-26334 NNP denotes M
T9210 26335-26344 VBD denotes decreased
T9211 26345-26348 DT denotes the
T9212 26349-26360 NN denotes association
T9213 26361-26368 IN denotes between
T9214 26369-26375 NNP denotes GATA-3
T9215 26376-26379 CC denotes and
T9216 26380-26390 JJ denotes importin-α
T9217 26391-26398 VBN denotes induced
T9218 26399-26401 IN denotes by
T9219 26402-26410 JJ denotes anti-CD3
T9220 26410-26411 NN denotes /
T9221 26411-26415 CD denotes CD28
T9222 26416-26427 NN denotes stimulation
T9223 26428-26430 IN denotes in
T9224 26431-26432 DT denotes a
T9225 26433-26456 JJ denotes concentration-dependent
T9226 26457-26463 NN denotes manner
T9227 26464-26465 -LRB- denotes (
T9228 26465-26471 NN denotes Figure
T9229 26472-26474 CD denotes 2C
T9230 26474-26475 -RRB- denotes )
T9231 26475-26476 . denotes .
T9232 26477-26479 IN denotes In
T9233 26480-26488 NN denotes addition
T9234 26488-26489 , denotes ,
T9235 26490-26495 VBG denotes using
T9236 26496-26508 JJ denotes GFP-labelled
T9237 26509-26515 NN denotes GATA-3
T9238 26516-26519 CC denotes and
T9239 26520-26528 JJ denotes confocal
T9240 26529-26539 NN denotes microscopy
T9241 26540-26542 PRP denotes we
T9242 26543-26555 VBD denotes demonstrated
T9243 26556-26560 IN denotes that
T9244 26561-26567 JJ denotes GATA-3
T9245 26568-26575 JJ denotes nuclear
T9246 26576-26582 NN denotes import
T9247 26583-26592 VBG denotes following
T9248 26593-26601 JJ denotes anti-CD3
T9249 26601-26602 NN denotes /
T9250 26602-26606 CD denotes CD28
T9251 26607-26618 NN denotes stimulation
T9252 26619-26622 IN denotes for
T9253 26623-26625 CD denotes 30
T9254 26626-26629 NN denotes min
T9255 26630-26633 VBD denotes was
T9256 26634-26644 VBN denotes attenuated
T9257 26645-26647 IN denotes by
T9258 26648-26660 NN denotes pretreatment
T9259 26661-26665 IN denotes with
T9260 26666-26668 NNP denotes FP
T9261 26669-26670 -LRB- denotes (
T9262 26670-26672 CD denotes 10
T9263 26672-26673 NN denotes −
T9264 26673-26674 CD denotes 8
T9265 26675-26676 NNP denotes M
T9266 26676-26677 -RRB- denotes )
T9267 26678-26679 -LRB- denotes (
T9268 26679-26685 NN denotes Figure
T9269 26686-26688 CD denotes 2D
T9270 26688-26689 -RRB- denotes )
T9271 26689-26690 . denotes .
T10194 28251-28257 NN denotes Effect
T10195 28258-28260 IN denotes on
T10196 28261-28266 NNP denotes MKP-1
T10197 28267-28280 NNP denotes Dexamethasone
T10198 28281-28289 VBZ denotes inhibits
T10199 28290-28293 CD denotes p38
T10200 28294-28298 NNP denotes MAPK
T10201 28299-28307 NN denotes function
T10202 28308-28310 IN denotes in
T10203 28311-28312 DT denotes a
T10204 28313-28317 NN denotes cell
T10205 28318-28322 NN denotes type
T10206 28323-28331 JJ denotes specific
T10207 28332-28338 NN denotes manner
T10208 28339-28346 IN denotes through
T10209 28347-28350 DT denotes the
T10210 28351-28356 JJ denotes rapid
T10211 28357-28366 NN denotes induction
T10212 28367-28369 IN denotes of
T10213 28370-28373 DT denotes the
T10214 28374-28378 JJ denotes dual
T10215 28379-28385 NN denotes kinase
T10216 28386-28397 NN denotes phosphatase
T10217 28398-28403 NNP denotes MKP-1
T10218 28404-28405 -LRB- denotes (
T10219 28405-28409 NNP denotes MAPK
T10220 28410-28423 JJ denotes phosphatase-1
T10221 28423-28424 -RRB- denotes )
T10222 28424-28425 , denotes ,
T10223 28426-28429 CC denotes and
T10224 28430-28434 DT denotes this
T10225 28435-28441 NN denotes effect
T10226 28442-28447 VBZ denotes lasts
T10227 28448-28451 IN denotes for
T10228 28452-28454 RB denotes up
T10229 28455-28457 TO denotes to
T10230 28458-28460 CD denotes 24
T10231 28461-28462 NN denotes h
T10232 28463-28464 NNP denotes [
T10233 28464-28466 CD denotes 28
T10234 28466-28467 NNP denotes ]
T10235 28467-28468 . denotes .
T10236 28469-28471 NNP denotes FP
T10237 28472-28473 -LRB- denotes (
T10238 28473-28475 CD denotes 10
T10239 28475-28476 NN denotes −
T10240 28476-28477 CD denotes 8
T10241 28478-28479 NNP denotes M
T10242 28479-28480 -RRB- denotes )
T10243 28481-28490 NN denotes treatment
T10244 28491-28493 IN denotes of
T10245 28494-28500 JJ denotes HuT-78
T10246 28501-28506 NNS denotes cells
T10247 28507-28516 VBN denotes activated
T10248 28517-28519 IN denotes by
T10249 28520-28528 JJ denotes anti-CD3
T10250 28528-28529 NN denotes /
T10251 28529-28533 CD denotes CD28
T10252 28534-28536 IN denotes in
T10253 28537-28542 NN denotes vitro
T10254 28543-28556 RB denotes significantly
T10255 28557-28566 VBD denotes decreased
T10256 28567-28570 CD denotes p38
T10257 28571-28575 NNP denotes MAPK
T10258 28576-28591 NN denotes phosphorylation
T10259 28592-28593 -LRB- denotes (
T10260 28593-28599 NN denotes Figure
T10261 28600-28602 NN denotes 3A
T10262 28602-28603 -RRB- denotes )
T10263 28604-28607 CC denotes and
T10264 28608-28616 NN denotes activity
T10265 28617-28625 VBN denotes measured
T10266 28626-28628 IN denotes by
T10267 28629-28644 NN denotes phosphorylation
T10268 28645-28647 IN denotes of
T10269 28648-28651 DT denotes the
T10270 28652-28662 JJ denotes downstream
T10271 28663-28669 NN denotes target
T10272 28670-28675 NNP denotes ATF-2
T10273 28676-28677 -LRB- denotes (
T10274 28677-28683 NNP denotes Figure
T10275 28684-28686 NNP denotes 3B
T10276 28686-28687 -RRB- denotes )
T10277 28687-28688 . denotes .
T10278 28689-28693 DT denotes This
T10279 28694-28700 NN denotes effect
T10280 28701-28704 VBD denotes was
T10281 28705-28713 VBN denotes detected
T10282 28714-28716 IN denotes at
T10283 28717-28719 CD denotes 30
T10284 28720-28723 NN denotes min
T10285 28724-28727 CC denotes and
T10286 28728-28734 VBD denotes lasted
T10287 28735-28738 IN denotes for
T10288 28739-28741 IN denotes at
T10289 28742-28747 JJS denotes least
T10290 28748-28750 CD denotes 14
T10291 28751-28752 NN denotes h
T10292 28753-28754 -LRB- denotes (
T10293 28754-28760 NN denotes Figure
T10294 28761-28763 NN denotes 3B
T10295 28763-28764 -RRB- denotes )
T10296 28764-28765 . denotes .
T10297 28766-28768 NNP denotes FP
T10298 28769-28770 -LRB- denotes (
T10299 28770-28772 CD denotes 10
T10300 28772-28773 NN denotes −
T10301 28773-28774 CD denotes 8
T10302 28775-28776 NNP denotes M
T10303 28776-28777 -RRB- denotes )
T10304 28778-28782 RB denotes also
T10305 28783-28796 RB denotes significantly
T10306 28797-28804 VBN denotes reduced
T10307 28805-28811 JJ denotes GATA-3
T10308 28812-28818 NN denotes serine
T10309 28819-28834 NN denotes phosphorylation
T10310 28835-28842 VBN denotes induced
T10311 28843-28845 IN denotes by
T10312 28846-28854 JJ denotes anti-CD3
T10313 28854-28855 NN denotes /
T10314 28855-28859 CD denotes CD28
T10315 28860-28871 NN denotes stimulation
T10316 28872-28874 IN denotes in
T10317 28875-28879 DT denotes both
T10318 28880-28881 DT denotes a
T10319 28882-28886 NN denotes time
T10320 28886-28887 : denotes -
T10321 28888-28891 CC denotes and
T10322 28892-28915 JJ denotes concentration-dependent
T10323 28916-28922 NN denotes manner
T10324 28923-28924 -LRB- denotes (
T10325 28924-28930 NN denotes Figure
T10326 28931-28933 NN denotes 3C
T10327 28933-28934 -RRB- denotes )
T10328 28934-28935 . denotes .
T10329 28936-28940 DT denotes This
T10330 28941-28950 NN denotes reduction
T10331 28951-28953 IN denotes in
T10332 28954-28960 JJ denotes GATA-3
T10333 28961-28976 NN denotes phosphorylation
T10334 28977-28980 VBD denotes was
T10335 28981-28985 RB denotes also
T10336 28986-28990 VBN denotes seen
T10337 28991-28995 IN denotes with
T10338 28996-29001 JJR denotes lower
T10339 29002-29016 NNS denotes concentrations
T10340 29017-29019 IN denotes of
T10341 29020-29022 NNP denotes FP
T10342 29022-29023 . denotes .
T10343 29024-29026 PRP denotes We
T10344 29027-29032 VBD denotes found
T10345 29033-29037 IN denotes that
T10346 29038-29040 NNP denotes FP
T10347 29041-29054 RB denotes significantly
T10348 29055-29062 VBD denotes induced
T10349 29063-29068 NNP denotes MKP-1
T10350 29069-29073 NNP denotes mRNA
T10351 29074-29076 IN denotes in
T10352 29077-29081 DT denotes both
T10353 29082-29083 DT denotes a
T10354 29084-29088 NN denotes time
T10355 29088-29089 : denotes -
T10356 29090-29093 CC denotes and
T10357 29094-29117 JJ denotes concentration-dependent
T10358 29118-29124 NN denotes manner
T10359 29124-29125 , denotes ,
T10360 29126-29134 VBG denotes reaching
T10361 29135-29136 DT denotes a
T10362 29137-29144 NN denotes plateau
T10363 29145-29147 IN denotes at
T10364 29148-29150 CD denotes 10
T10365 29150-29151 NN denotes −
T10366 29151-29152 CD denotes 8
T10367 29153-29154 NNP denotes M
T10368 29155-29160 IN denotes after
T10369 29161-29163 CD denotes 10
T10370 29164-29167 NN denotes min
T10371 29168-29169 -LRB- denotes (
T10372 29169-29175 NN denotes Figure
T10373 29176-29178 CD denotes 3D
T10374 29179-29182 CC denotes and
T10375 29183-29185 CD denotes 3E
T10376 29185-29186 -RRB- denotes )
T10377 29186-29187 . denotes .
T10378 29188-29195 RB denotes However
T10379 29195-29196 , denotes ,
T10380 29197-29200 DT denotes the
T10381 29201-29208 NNS denotes effects
T10382 29209-29211 IN denotes of
T10383 29212-29214 NNP denotes FP
T10384 29215-29217 IN denotes on
T10385 29218-29224 NNP denotes GATA-3
T10386 29225-29232 JJ denotes nuclear
T10387 29233-29239 NN denotes import
T10388 29239-29240 , denotes ,
T10389 29241-29251 JJ denotes importin-α
T10390 29252-29263 NN denotes association
T10391 29264-29267 CC denotes and
T10392 29268-29272 NN denotes IL-4
T10393 29273-29277 NNP denotes mRNA
T10394 29278-29288 NN denotes expression
T10395 29289-29292 VBP denotes are
T10396 29293-29297 VBN denotes seen
T10397 29298-29300 IN denotes at
T10398 29301-29312 CD denotes 10,000-fold
T10399 29313-29318 JJR denotes lower
T10400 29319-29333 NNS denotes concentrations
T10401 29334-29335 -LRB- denotes (
T10402 29335-29337 CD denotes 10
T10403 29337-29338 NN denotes −
T10404 29338-29340 CD denotes 12
T10405 29341-29342 NNP denotes M
T10406 29342-29343 , denotes ,
T10407 29344-29347 VBP denotes see
T10408 29348-29354 NN denotes Figure
T10409 29355-29356 CD denotes 2
T10410 29356-29357 -RRB- denotes )
T10411 29357-29358 . denotes .
T10412 30668-30673 VBG denotes Using
T10413 30674-30676 DT denotes an
T10414 30677-30679 IN denotes in
T10415 30680-30685 NN denotes vitro
T10416 30686-30697 NN denotes competition
T10417 30698-30703 NN denotes assay
T10418 30704-30705 -LRB- denotes (
T10419 30705-30711 NN denotes Figure
T10420 30712-30714 NN denotes 4A
T10421 30714-30715 -RRB- denotes )
T10422 30716-30725 VBG denotes utilizing
T10423 30726-30734 JJ denotes purified
T10424 30735-30744 VBN denotes activated
T10425 30745-30751 NN denotes GATA-3
T10426 30751-30752 , denotes ,
T10427 30753-30763 NN denotes importin-α
T10428 30763-30764 , denotes ,
T10429 30765-30768 CC denotes and
T10430 30769-30778 VBD denotes activated
T10431 30779-30781 NNP denotes GR
T10432 30781-30782 , denotes ,
T10433 30783-30785 PRP denotes we
T10434 30786-30798 VBD denotes demonstrated
T10435 30799-30803 IN denotes that
T10436 30804-30813 VBN denotes activated
T10437 30814-30816 NNP denotes GR
T10438 30817-30830 RB denotes significantly
T10439 30831-30840 VBD denotes increased
T10440 30841-30854 JJ denotes GR-importin-α
T10441 30855-30866 NN denotes association
T10442 30867-30869 IN denotes in
T10443 30870-30873 DT denotes the
T10444 30874-30882 NN denotes presence
T10445 30883-30886 CC denotes and
T10446 30887-30894 NN denotes absence
T10447 30895-30897 IN denotes of
T10448 30898-30907 VBN denotes activated
T10449 30908-30914 NNP denotes GATA-3
T10450 30915-30916 -LRB- denotes (
T10451 30916-30922 NNP denotes Figure
T10452 30923-30925 NNP denotes 4B
T10453 30925-30926 -RRB- denotes )
T10454 30926-30927 . denotes .
T10455 30928-30932 DT denotes This
T10456 30933-30939 NN denotes effect
T10457 30940-30942 VBZ denotes is
T10458 30943-30946 RB denotes not
T10459 30947-30953 JJ denotes mutual
T10460 30953-30954 , denotes ,
T10461 30955-30960 IN denotes since
T10462 30961-30970 VBN denotes activated
T10463 30971-30977 NNP denotes GATA-3
T10464 30978-30981 VBD denotes did
T10465 30982-30985 RB denotes not
T10466 30986-30991 VB denotes block
T10467 30992-30994 NNP denotes GR
T10468 30995-31005 JJ denotes importin-α
T10469 31006-31017 NN denotes association
T10470 31018-31019 -LRB- denotes (
T10471 31019-31025 NN denotes Figure
T10472 31026-31028 NN denotes 4C
T10473 31028-31029 -RRB- denotes )
T10474 31029-31030 . denotes .
T10475 31031-31036 DT denotes These
T10476 31037-31041 NNS denotes data
T10477 31042-31046 RB denotes also
T10478 31047-31054 VBP denotes suggest
T10479 31055-31059 IN denotes that
T10480 31060-31064 DT denotes both
T10481 31065-31074 VBN denotes activated
T10482 31075-31077 NNP denotes GR
T10483 31078-31081 CC denotes and
T10484 31082-31096 NNP denotes phospho-GATA-3
T10485 31097-31100 MD denotes can
T10486 31101-31109 RB denotes directly
T10487 31110-31119 VB denotes associate
T10488 31120-31124 IN denotes with
T10489 31125-31135 JJ denotes importin-α
T10490 31136-31137 -LRB- denotes (
T10491 31137-31143 NNP denotes Figure
T10492 31144-31146 NNP denotes 4D
T10493 31146-31147 -RRB- denotes )
T10494 31148-31151 CC denotes and
T10495 31152-31156 IN denotes that
T10496 31157-31166 VBN denotes activated
T10497 31167-31169 NNP denotes GR
T10498 31170-31180 VBZ denotes attenuates
T10499 31181-31184 DT denotes the
T10500 31185-31199 JJ denotes phospho-GATA-3
T10501 31199-31200 NN denotes /
T10502 31200-31210 JJ denotes importin-α
T10503 31211-31222 NN denotes interaction
T10504 31223-31225 IN denotes in
T10505 31226-31227 DT denotes a
T10506 31228-31251 JJ denotes concentration-dependent
T10507 31252-31258 NN denotes manner
T10508 31259-31260 -LRB- denotes (
T10509 31260-31266 NN denotes Figure
T10510 31267-31269 CD denotes 4E
T10511 31269-31270 -RRB- denotes )
T10512 31270-31271 . denotes .
T10513 31272-31280 RB denotes Together
T10514 31280-31281 , denotes ,
T10515 31282-31286 DT denotes this
T10516 31287-31295 VBZ denotes suggests
T10517 31296-31300 IN denotes that
T10518 31301-31317 JJ denotes ligand-activated
T10519 31318-31320 NNP denotes GR
T10520 31321-31324 MD denotes may
T10521 31325-31332 VB denotes compete
T10522 31333-31337 IN denotes with
T10523 31338-31352 JJ denotes phospho-GATA-3
T10524 31353-31356 IN denotes for
T10525 31357-31367 JJ denotes importin-α
T10526 31368-31371 CC denotes and
T10527 31372-31379 RB denotes thereby
T10528 31380-31385 NN denotes limit
T10529 31386-31392 JJ denotes GATA-3
T10530 31393-31400 JJ denotes nuclear
T10531 31401-31407 NN denotes import
T10532 31407-31408 . denotes .
T10533 32497-32502 JJ denotes Other
T10534 32503-32511 JJ denotes possible
T10535 32512-32527 NNS denotes interpretations
T10536 32528-32530 IN denotes of
T10537 32531-32534 PRP$ denotes our
T10538 32535-32542 NNS denotes results
T10539 32543-32548 MD denotes could
T10540 32549-32556 VB denotes include
T10541 32557-32559 DT denotes an
T10542 32560-32566 NN denotes effect
T10543 32567-32569 IN denotes of
T10544 32570-32572 NNP denotes FP
T10545 32573-32575 IN denotes on
T10546 32576-32582 NNP denotes GATA-3
T10547 32583-32590 JJ denotes nuclear
T10548 32591-32597 NN denotes export
T10549 32598-32604 CC denotes and/or
T10550 32605-32616 NN denotes degradation
T10551 32616-32617 . denotes .
T10552 32618-32628 NNP denotes Leptomycin
T10553 32629-32630 NNP denotes B
T10554 32630-32631 , denotes ,
T10555 32632-32637 WDT denotes which
T10556 32638-32646 VBZ denotes inhibits
T10557 32647-32654 JJ denotes nuclear
T10558 32655-32661 NN denotes export
T10559 32661-32662 , denotes ,
T10560 32663-32666 VBD denotes did
T10561 32667-32670 RB denotes not
T10562 32671-32677 VB denotes affect
T10563 32678-32681 DT denotes the
T10564 32682-32689 NN denotes ability
T10565 32690-32692 IN denotes of
T10566 32693-32695 NNP denotes FP
T10567 32696-32698 TO denotes to
T10568 32699-32704 VB denotes block
T10569 32705-32711 JJ denotes GATA-3
T10570 32712-32719 JJ denotes nuclear
T10571 32720-32732 NN denotes localization
T10572 32733-32734 -LRB- denotes (
T10573 32734-32740 NN denotes Figure
T10574 32741-32743 NN denotes 5A
T10575 32743-32744 -RRB- denotes )
T10576 32744-32745 . denotes .
T10577 32746-32758 RB denotes Additionally
T10578 32758-32759 , denotes ,
T10579 32760-32762 NNP denotes FP
T10580 32763-32766 VBD denotes had
T10581 32767-32769 DT denotes no
T10582 32770-32776 NN denotes effect
T10583 32777-32779 IN denotes on
T10584 32780-32785 JJ denotes whole
T10585 32786-32790 NN denotes cell
T10586 32791-32797 NN denotes GATA-3
T10587 32798-32808 NN denotes expression
T10588 32809-32815 IN denotes during
T10589 32816-32819 DT denotes the
T10590 32820-32824 NN denotes time
T10591 32825-32831 NN denotes course
T10592 32832-32834 IN denotes of
T10593 32835-32840 DT denotes these
T10594 32841-32852 NNS denotes experiments
T10595 32853-32854 -LRB- denotes (
T10596 32854-32860 NN denotes Figure
T10597 32861-32863 NN denotes 5B
T10598 32863-32864 -RRB- denotes )
T10599 32864-32865 . denotes .
T10600 32866-32869 CC denotes Nor
T10601 32870-32873 VBD denotes did
T10602 32874-32882 NN denotes addition
T10603 32883-32885 IN denotes of
T10604 32886-32888 NNP denotes FP
T10605 32889-32899 JJ denotes subsequent
T10606 32900-32902 TO denotes to
T10607 32903-32911 JJ denotes anti-CD3
T10608 32911-32912 NN denotes /
T10609 32912-32916 CD denotes CD28
T10610 32917-32924 JJ denotes nuclear
T10611 32925-32938 NN denotes translocation
T10612 32939-32945 VB denotes affect
T10613 32946-32952 JJ denotes GATA-3
T10614 32953-32960 JJ denotes nuclear
T10615 32961-32970 NN denotes residency
T10616 32971-32972 -LRB- denotes (
T10617 32972-32978 NN denotes Figure
T10618 32979-32981 NN denotes 5C
T10619 32981-32982 -RRB- denotes )
T10620 32982-32983 , denotes ,
T10621 32984-32994 VBG denotes suggesting
T10622 32995-32999 IN denotes that
T10623 33000-33009 VBN denotes activated
T10624 33010-33012 NNP denotes GR
T10625 33013-33017 VBZ denotes does
T10626 33018-33021 RB denotes not
T10627 33022-33029 VB denotes enhance
T10628 33030-33036 JJ denotes GATA-3
T10629 33037-33044 JJ denotes nuclear
T10630 33045-33051 NN denotes export
T10631 33051-33052 . denotes .
T10632 33053-33060 RB denotes Finally
T10633 33060-33061 , denotes ,
T10634 33062-33065 DT denotes the
T10635 33066-33072 NN denotes effect
T10636 33073-33075 IN denotes of
T10637 33076-33078 NNP denotes FP
T10638 33079-33081 IN denotes on
T10639 33082-33088 NNP denotes GATA-3
T10640 33089-33096 JJ denotes nuclear
T10641 33097-33103 NN denotes import
T10642 33104-33107 VBD denotes was
T10643 33108-33111 RB denotes not
T10644 33112-33123 JJ denotes nonspecific
T10645 33123-33124 , denotes ,
T10646 33125-33130 IN denotes since
T10647 33131-33133 NNP denotes FP
T10648 33134-33135 -LRB- denotes (
T10649 33135-33137 CD denotes 10
T10650 33137-33138 NN denotes −
T10651 33138-33139 CD denotes 8
T10652 33140-33141 NNP denotes M
T10653 33141-33142 -RRB- denotes )
T10654 33143-33146 VBD denotes had
T10655 33147-33149 DT denotes no
T10656 33150-33156 NN denotes effect
T10657 33157-33159 IN denotes on
T10658 33160-33163 CD denotes p65
T10659 33164-33171 JJ denotes nuclear
T10660 33172-33185 NN denotes translocation
T10661 33186-33194 VBN denotes measured
T10662 33195-33197 IN denotes at
T10663 33198-33200 CD denotes 60
T10664 33201-33204 NN denotes min
T10665 33205-33206 -LRB- denotes (
T10666 33206-33212 NN denotes Figure
T10667 33213-33215 CD denotes 5D
T10668 33215-33216 -RRB- denotes )
T10669 33216-33217 . denotes .
T11922 34269-34272 DT denotes The
T11923 34273-34283 NNP denotes Inhibitory
T11924 34284-34290 NN denotes Effect
T11925 34291-34293 IN denotes of
T11926 34294-34309 NNS denotes Corticosteroids
T11927 34310-34312 IN denotes on
T11928 34313-34319 NNP denotes GATA-3
T11929 34320-34327 NNP denotes Nuclear
T11930 34328-34340 NNP denotes Localization
T11931 34341-34343 IN denotes in
T11932 34344-34351 JJ denotes Primary
T11933 34352-34353 NNP denotes T
T11934 34354-34365 NNP denotes Lymphocytes
T11935 34366-34368 NNP denotes Ex
T11936 34369-34373 NNP denotes Vivo
T11937 34374-34377 CC denotes and
T11938 34378-34380 IN denotes In
T11939 34381-34385 NNP denotes Vivo
T11940 34386-34395 NNP denotes Treatment
T11941 34396-34400 IN denotes with
T11942 34401-34403 NNP denotes FP
T11943 34404-34406 FW denotes ex
T11944 34407-34411 FW denotes vivo
T11945 34412-34424 VBD denotes demonstrated
T11946 34425-34426 DT denotes a
T11947 34427-34450 JJ denotes concentration-dependent
T11948 34451-34459 NN denotes decrease
T11949 34460-34462 IN denotes in
T11950 34463-34466 DT denotes the
T11951 34467-34473 JJ denotes direct
T11952 34474-34485 NN denotes interaction
T11953 34486-34493 IN denotes between
T11954 34494-34508 JJ denotes phospho-GATA-3
T11955 34509-34512 CC denotes and
T11956 34513-34523 JJ denotes importin-α
T11957 34524-34526 IN denotes in
T11958 34527-34532 NNS denotes PBMCs
T11959 34533-34537 IN denotes from
T11960 34538-34546 NNS denotes patients
T11961 34547-34551 IN denotes with
T11962 34552-34558 NN denotes asthma
T11963 34559-34560 -LRB- denotes (
T11964 34560-34566 NN denotes Figure
T11965 34567-34569 NN denotes 6A
T11966 34570-34573 CC denotes and
T11967 34574-34576 NN denotes 6B
T11968 34576-34577 -RRB- denotes )
T11969 34577-34578 , denotes ,
T11970 34579-34584 WDT denotes which
T11971 34585-34588 VBD denotes was
T11972 34589-34602 RB denotes significantly
T11973 34603-34612 VBN denotes inhibited
T11974 34613-34615 IN denotes at
T11975 34616-34618 CD denotes 10
T11976 34618-34619 CD denotes −
T11977 34619-34621 CD denotes 12
T11978 34622-34623 NNP denotes M
T11979 34624-34626 NNP denotes FP
T11980 34627-34628 -LRB- denotes (
T11981 34628-34629 FW denotes p
T11982 34629-34630 FW denotes <
T11983 34630-34635 CD denotes 0.001
T11984 34635-34636 , denotes ,
T11985 34637-34642 NNP denotes ANOVA
T11986 34643-34646 CC denotes and
T11987 34647-34659 NNP denotes Newman-Keuls
T11988 34660-34664 NN denotes test
T11989 34664-34665 -RRB- denotes )
T11990 34666-34669 CC denotes and
T11991 34670-34680 RB denotes completely
T11992 34681-34691 VBN denotes attenuated
T11993 34692-34694 IN denotes by
T11994 34695-34697 CD denotes 10
T11995 34697-34698 NN denotes −
T11996 34698-34699 CD denotes 8
T11997 34700-34701 NNP denotes M
T11998 34702-34704 NNP denotes FP
T11999 34705-34706 -LRB- denotes (
T12000 34706-34707 FW denotes p
T12001 34707-34708 FW denotes <
T12002 34708-34713 CD denotes 0.001
T12003 34713-34714 , denotes ,
T12004 34715-34720 NNP denotes ANOVA
T12005 34721-34724 CC denotes and
T12006 34725-34737 NNP denotes Newman-Keuls
T12007 34738-34742 NN denotes test
T12008 34742-34743 -RRB- denotes )
T12009 34743-34744 . denotes .
T12010 35694-35697 PRP$ denotes Our
T12011 35698-35706 JJ denotes previous
T12012 35707-35708 NNP denotes T
T12013 35709-35713 NN denotes cell
T12014 35714-35718 NN denotes line
T12015 35719-35726 NNS denotes studies
T12016 35727-35736 VBD denotes indicated
T12017 35737-35741 IN denotes that
T12018 35742-35744 CD denotes 10
T12019 35744-35745 CD denotes −
T12020 35745-35747 CD denotes 12
T12021 35748-35749 NNP denotes M
T12022 35750-35752 NNP denotes FP
T12023 35753-35763 VBZ denotes suppresses
T12024 35764-35768 NN denotes IL-4
T12025 35769-35772 CC denotes and
T12026 35773-35775 CD denotes -5
T12027 35776-35780 NN denotes gene
T12028 35781-35791 NN denotes expression
T12029 35792-35795 CC denotes and
T12030 35796-35806 VBD denotes attenuated
T12031 35807-35810 DT denotes the
T12032 35811-35822 NN denotes interaction
T12033 35823-35825 IN denotes of
T12034 35826-35832 NN denotes GATA-3
T12035 35833-35837 IN denotes with
T12036 35838-35848 JJ denotes importin-α
T12037 35849-35850 -LRB- denotes (
T12038 35850-35853 VB denotes see
T12039 35854-35861 NNS denotes Figures
T12040 35862-35864 CD denotes 1D
T12041 35865-35868 CC denotes and
T12042 35869-35870 CD denotes 2
T12043 35870-35871 -RRB- denotes )
T12044 35871-35872 . denotes .
T12045 35873-35877 DT denotes This
T12046 35878-35891 NN denotes concentration
T12047 35892-35894 VBZ denotes is
T12048 35895-35900 JJ denotes close
T12049 35901-35903 TO denotes to
T12050 35904-35908 VB denotes peak
T12051 35909-35915 NN denotes plasma
T12052 35916-35922 NNS denotes levels
T12053 35923-35931 VBN denotes obtained
T12054 35932-35936 IN denotes from
T12055 35937-35946 JJ denotes asthmatic
T12056 35947-35955 NNS denotes patients
T12057 35956-35963 VBN denotes treated
T12058 35964-35968 IN denotes with
T12059 35969-35976 JJ denotes inhaled
T12060 35977-35979 NNP denotes FP
T12061 35980-35981 -LRB- denotes (
T12062 35981-35984 CD denotes 500
T12063 35985-35987 NN denotes µg
T12064 35987-35988 -RRB- denotes )
T12065 35989-35990 NNP denotes [
T12066 35990-35992 CD denotes 27
T12067 35992-35993 NNP denotes ]
T12068 35993-35994 . denotes .
T12069 35995-36002 VBN denotes Inhaled
T12070 36003-36005 NNP denotes FP
T12071 36006-36007 -LRB- denotes (
T12072 36007-36010 CD denotes 500
T12073 36011-36013 NN denotes µg
T12074 36013-36014 -RRB- denotes )
T12075 36015-36024 NN denotes treatment
T12076 36025-36027 IN denotes of
T12077 36028-36033 CD denotes seven
T12078 36034-36047 JJ denotes steroid-naive
T12079 36048-36054 NN denotes asthma
T12080 36055-36063 NNS denotes patients
T12081 36064-36077 RB denotes significantly
T12082 36078-36085 VBD denotes reduced
T12083 36086-36092 NNP denotes GATA-3
T12084 36093-36103 JJ denotes importin-α
T12085 36104-36115 NN denotes interaction
T12086 36116-36118 IN denotes in
T12087 36119-36123 NN denotes vivo
T12088 36124-36126 IN denotes in
T12089 36127-36128 DT denotes a
T12090 36129-36143 JJ denotes time-dependent
T12091 36144-36150 NN denotes manner
T12092 36150-36151 . denotes .
T12093 36152-36156 DT denotes This
T12094 36157-36165 VBD denotes produced
T12095 36166-36167 DT denotes a
T12096 36168-36169 NN denotes >
T12097 36169-36171 CD denotes 90
T12098 36171-36172 NN denotes %
T12099 36173-36181 NN denotes decrease
T12100 36182-36184 IN denotes in
T12101 36185-36191 NNP denotes GATA-3
T12102 36192-36202 JJ denotes importin-α
T12103 36203-36214 NN denotes association
T12104 36215-36217 IN denotes at
T12105 36218-36219 CD denotes 2
T12106 36220-36221 NN denotes h
T12107 36222-36223 -LRB- denotes (
T12108 36223-36229 JJ denotes median
T12109 36230-36231 NNP denotes [
T12110 36231-36233 CD denotes 95
T12111 36233-36234 NN denotes %
T12112 36235-36237 NNP denotes CI
T12113 36237-36238 NNP denotes ]
T12114 36238-36239 , denotes ,
T12115 36240-36246 CD denotes 13,494
T12116 36247-36248 NNP denotes [
T12117 36248-36253 CD denotes 6,828
T12118 36254-36260 CD denotes 17,829
T12119 36260-36261 NNP denotes ]
T12120 36262-36268 CC denotes versus
T12121 36269-36272 CD denotes 879
T12122 36273-36274 JJ denotes [
T12123 36274-36277 CD denotes 597
T12124 36278-36283 CD denotes 1,165
T12125 36283-36284 NNP denotes ]
T12126 36284-36285 : denotes ;
T12127 36286-36287 VB denotes p
T12128 36287-36288 RB denotes <
T12129 36288-36292 CD denotes 0.05
T12130 36293-36301 NNP denotes Friedman
T12131 36301-36303 POS denotes 's
T12132 36304-36312 NN denotes analysis
T12133 36312-36313 -RRB- denotes )
T12134 36313-36314 . denotes .
T12135 36315-36322 RB denotes However
T12136 36322-36323 , denotes ,
T12137 36324-36328 DT denotes this
T12138 36329-36332 VBD denotes did
T12139 36333-36336 RB denotes not
T12140 36337-36342 VB denotes reach
T12141 36343-36355 NN denotes significance
T12142 36356-36361 VBG denotes using
T12143 36362-36370 NNP denotes Wilcoxon
T12144 36370-36372 POS denotes 's
T12145 36373-36382 JJ denotes post-test
T12146 36383-36391 NN denotes analysis
T12147 36392-36393 -LRB- denotes (
T12148 36393-36394 NNP denotes W
T12149 36395-36396 SYM denotes =
T12150 36397-36401 CD denotes 6.00
T12151 36401-36402 -RRB- denotes )
T12152 36403-36411 RB denotes probably
T12153 36412-36415 JJ denotes due
T12154 36416-36418 TO denotes to
T12155 36419-36422 JJ denotes low
T12156 36423-36430 NNS denotes numbers
T12157 36431-36433 IN denotes of
T12158 36434-36446 NNS denotes participants
T12159 36446-36447 . denotes .
T12160 36448-36455 JJ denotes Similar
T12161 36456-36463 NNS denotes results
T12162 36464-36468 VBD denotes were
T12163 36469-36477 VBN denotes observed
T12164 36478-36482 WRB denotes when
T12165 36483-36489 NNP denotes GATA-3
T12166 36490-36500 JJ denotes importin-α
T12167 36501-36512 NN denotes association
T12168 36513-36516 VBD denotes was
T12169 36517-36525 VBN denotes measured
T12170 36526-36527 -LRB- denotes (
T12171 36527-36533 NNP denotes Figure
T12172 36534-36536 NNP denotes 6C
T12173 36537-36540 CC denotes and
T12174 36541-36543 NNP denotes 6D
T12175 36543-36544 -RRB- denotes )
T12176 36544-36545 . denotes .
T12177 36546-36549 DT denotes The
T12178 36550-36555 JJR denotes lower
T12179 36556-36560 NN denotes dose
T12180 36561-36563 IN denotes of
T12181 36564-36566 NNP denotes FP
T12182 36567-36568 -LRB- denotes (
T12183 36568-36571 CD denotes 100
T12184 36572-36574 NN denotes µg
T12185 36574-36575 -RRB- denotes )
T12186 36576-36579 VBD denotes was
T12187 36580-36583 RB denotes not
T12188 36584-36593 JJ denotes effective
T12189 36593-36594 . denotes .
T12190 36595-36598 DT denotes The
T12191 36599-36609 JJ denotes attenuated
T12192 36610-36621 NN denotes interaction
T12193 36622-36624 IN denotes of
T12194 36625-36631 NN denotes GATA-3
T12195 36632-36635 VBD denotes did
T12196 36636-36639 RB denotes not
T12197 36640-36646 VB denotes result
T12198 36647-36651 IN denotes from
T12199 36652-36655 DT denotes the
T12200 36656-36665 JJ denotes defective
T12201 36666-36675 NN denotes recycling
T12202 36676-36678 IN denotes of
T12203 36679-36689 NN denotes importin-α
T12204 36689-36690 , denotes ,
T12205 36691-36693 IN denotes as
T12206 36694-36695 DT denotes a
T12207 36696-36707 JJ denotes significant
T12208 36708-36716 NN denotes decrease
T12209 36717-36719 IN denotes in
T12210 36720-36723 DT denotes the
T12211 36724-36733 NN denotes abundance
T12212 36734-36736 IN denotes of
T12213 36737-36747 NN denotes importin-α
T12214 36748-36750 IN denotes in
T12215 36751-36754 DT denotes the
T12216 36755-36766 JJ denotes cytoplasmic
T12217 36767-36771 NN denotes pool
T12218 36772-36775 VBD denotes was
T12219 36776-36779 RB denotes not
T12220 36780-36788 VBN denotes detected
T12221 36789-36790 -LRB- denotes (
T12222 36790-36796 NN denotes Figure
T12223 36797-36799 CD denotes 6E
T12224 36799-36800 -RRB- denotes )
T12225 36800-36801 . denotes .
T12226 36802-36804 PRP denotes We
T12227 36805-36812 RB denotes further
T12228 36813-36821 VBD denotes examined
T12229 36822-36829 IN denotes whether
T12230 36830-36837 JJ denotes inhaled
T12231 36838-36840 NNP denotes FP
T12232 36841-36846 MD denotes could
T12233 36847-36853 VB denotes affect
T12234 36854-36862 JJ denotes cellular
T12235 36863-36875 NN denotes localization
T12236 36876-36878 IN denotes of
T12237 36879-36885 NN denotes GATA-3
T12238 36886-36888 IN denotes in
T12239 36889-36899 JJ denotes peripheral
T12240 36900-36905 NN denotes blood
T12241 36906-36907 NNP denotes T
T12242 36908-36913 NNS denotes cells
T12243 36913-36914 . denotes .
T12244 36915-36924 NNP denotes Treatment
T12245 36925-36929 IN denotes with
T12246 36930-36937 JJ denotes inhaled
T12247 36938-36940 NNP denotes FP
T12248 36941-36942 -LRB- denotes (
T12249 36942-36945 CD denotes 500
T12250 36946-36948 NN denotes µg
T12251 36948-36949 -RRB- denotes )
T12252 36950-36953 IN denotes for
T12253 36954-36955 CD denotes 2
T12254 36956-36957 NN denotes h
T12255 36958-36971 RB denotes significantly
T12256 36972-36981 VBD denotes increased
T12257 36982-36984 NNP denotes GR
T12258 36985-36992 JJ denotes nuclear
T12259 36993-37006 NN denotes translocation
T12260 37007-37008 -LRB- denotes (
T12261 37008-37014 NN denotes Figure
T12262 37015-37017 NN denotes 7A
T12263 37017-37018 -RRB- denotes )
T12264 37019-37022 CC denotes and
T12265 37023-37036 RB denotes concomitantly
T12266 37037-37046 VBD denotes decreased
T12267 37047-37050 DT denotes the
T12268 37051-37057 NN denotes number
T12269 37058-37060 IN denotes of
T12270 37061-37068 JJ denotes nuclear
T12271 37069-37075 JJ denotes GATA-3
T12272 37076-37090 JJ denotes immunoreactive
T12273 37091-37101 JJ denotes peripheral
T12274 37102-37107 NN denotes blood
T12275 37108-37109 NNP denotes T
T12276 37110-37115 NNS denotes cells
T12277 37116-37117 -LRB- denotes (
T12278 37117-37119 CD denotes 37
T12279 37119-37120 NN denotes %
T12280 37120-37121 CD denotes ±
T12281 37121-37124 CD denotes 4.2
T12282 37124-37125 NN denotes %
T12283 37126-37132 CC denotes versus
T12284 37133-37137 CD denotes 58.2
T12285 37137-37138 NN denotes %
T12286 37138-37139 CD denotes ±
T12287 37139-37143 CD denotes 4.95
T12288 37143-37144 NN denotes %
T12289 37144-37145 , denotes ,
T12290 37146-37147 VBP denotes p
T12291 37148-37149 SYM denotes =
T12292 37150-37155 CD denotes 0.016
T12293 37155-37156 , denotes ,
T12294 37157-37158 NNP denotes W
T12295 37159-37160 SYM denotes =
T12296 37161-37165 CD denotes 28.0
T12297 37165-37166 , denotes ,
T12298 37167-37175 NNP denotes Wilcoxon
T12299 37175-37177 POS denotes 's
T12300 37178-37182 NN denotes rank
T12301 37183-37187 NN denotes test
T12302 37187-37188 -RRB- denotes )
T12303 37189-37197 VBN denotes compared
T12304 37198-37202 IN denotes with
T12305 37203-37210 NN denotes placebo
T12306 37211-37213 IN denotes as
T12307 37214-37222 VBN denotes measured
T12308 37223-37225 IN denotes by
T12309 37226-37245 NN denotes immunocytochemistry
T12310 37246-37247 -LRB- denotes (
T12311 37247-37253 NN denotes Figure
T12312 37254-37256 NN denotes 7A
T12313 37257-37260 CC denotes and
T12314 37261-37263 NN denotes 7B
T12315 37263-37264 -RRB- denotes )
T12316 37264-37265 . denotes .
T12317 37266-37270 DT denotes This
T12318 37271-37274 VBD denotes was
T12319 37275-37284 VBN denotes confirmed
T12320 37285-37287 IN denotes by
T12321 37288-37295 JJ denotes Western
T12322 37296-37304 VBG denotes blotting
T12323 37304-37305 , denotes ,
T12324 37306-37311 WDT denotes which
T12325 37312-37316 RB denotes also
T12326 37317-37326 VBD denotes indicated
T12327 37327-37331 IN denotes that
T12328 37332-37336 DT denotes this
T12329 37337-37343 NN denotes effect
T12330 37344-37347 VBD denotes was
T12331 37348-37352 DT denotes both
T12332 37353-37357 NN denotes time
T12333 37357-37358 : denotes -
T12334 37359-37362 CC denotes and
T12335 37363-37377 JJ denotes dose-dependent
T12336 37378-37379 -LRB- denotes (
T12337 37379-37385 NNP denotes Figure
T12338 37386-37388 NNP denotes 7C
T12339 37389-37392 CC denotes and
T12340 37393-37395 NNP denotes 7D
T12341 37395-37396 -RRB- denotes )
T12342 37396-37397 . denotes .
T12343 37398-37402 RB denotes Thus
T12344 37402-37403 , denotes ,
T12345 37404-37411 VBD denotes inhaled
T12346 37412-37414 NNP denotes FP
T12347 37415-37416 -LRB- denotes (
T12348 37416-37419 CD denotes 500
T12349 37420-37422 NN denotes µg
T12350 37422-37423 -RRB- denotes )
T12351 37424-37431 VBD denotes induced
T12352 37432-37443 JJ denotes significant
T12353 37444-37448 NN denotes loss
T12354 37449-37451 IN denotes in
T12355 37452-37459 JJ denotes nuclear
T12356 37460-37466 NN denotes GATA-3
T12357 37467-37469 IN denotes at
T12358 37470-37471 CD denotes 2
T12359 37472-37473 NN denotes h
T12360 37474-37475 -LRB- denotes (
T12361 37475-37481 JJ denotes median
T12362 37482-37483 NNP denotes [
T12363 37483-37485 CD denotes 95
T12364 37485-37486 NN denotes %
T12365 37487-37489 NNP denotes CI
T12366 37489-37490 NNP denotes ]
T12367 37490-37491 , denotes ,
T12368 37492-37496 CD denotes 0.40
T12369 37497-37498 NNP denotes [
T12370 37498-37502 CD denotes 0.27
T12371 37503-37507 CD denotes 0.53
T12372 37507-37508 NNP denotes ]
T12373 37509-37515 CC denotes versus
T12374 37516-37520 CD denotes 0.14
T12375 37521-37522 NNP denotes [
T12376 37522-37526 CD denotes 0.11
T12377 37527-37531 CD denotes 0.19
T12378 37531-37532 NNP denotes ]
T12379 37532-37533 , denotes ,
T12380 37534-37535 NN denotes p
T12381 37535-37536 NN denotes <
T12382 37536-37540 CD denotes 0.05
T12383 37540-37541 , denotes ,
T12384 37542-37543 NNP denotes W
T12385 37544-37545 SYM denotes =
T12386 37546-37551 CD denotes 21.00
T12387 37551-37552 , denotes ,
T12388 37553-37561 NNP denotes Wilcoxon
T12389 37561-37563 POS denotes 's
T12390 37564-37568 NN denotes rank
T12391 37569-37573 NN denotes test
T12392 37573-37574 -RRB- denotes )
T12393 37575-37576 -LRB- denotes (
T12394 37576-37582 NN denotes Figure
T12395 37583-37585 NN denotes 7C
T12396 37585-37586 -RRB- denotes )
T12397 37587-37590 CC denotes and
T12398 37591-37602 JJ denotes cytoplasmic
T12399 37603-37609 NN denotes GATA-3
T12400 37610-37616 NNS denotes levels
T12401 37617-37621 VBD denotes were
T12402 37622-37630 VBN denotes enhanced
T12403 37631-37633 IN denotes by
T12404 37634-37641 JJ denotes inhaled
T12405 37642-37644 NNP denotes FP
T12406 37645-37647 IN denotes in
T12407 37648-37649 DT denotes a
T12408 37650-37664 JJ denotes dose-dependent
T12409 37665-37671 NN denotes manner
T12410 37672-37673 -LRB- denotes (
T12411 37673-37679 JJ denotes median
T12412 37680-37681 NNP denotes [
T12413 37681-37683 CD denotes 95
T12414 37683-37684 NN denotes %
T12415 37685-37687 NNP denotes CI
T12416 37687-37688 NNP denotes ]
T12417 37688-37689 , denotes ,
T12418 37690-37696 CD denotes 0.0032
T12419 37697-37698 NNP denotes [
T12420 37698-37704 CD denotes 0.0026
T12421 37705-37711 CD denotes 0.0039
T12422 37711-37712 NNP denotes ]
T12423 37713-37719 CC denotes versus
T12424 37720-37725 CD denotes 0.658
T12425 37726-37727 NNP denotes [
T12426 37727-37732 CD denotes 0.592
T12427 37733-37738 CD denotes 0.720
T12428 37738-37739 NNP denotes ]
T12429 37739-37740 , denotes ,
T12430 37741-37742 NN denotes p
T12431 37742-37743 NN denotes <
T12432 37743-37747 CD denotes 0.05
T12433 37747-37748 , denotes ,
T12434 37749-37750 NNP denotes W
T12435 37751-37752 SYM denotes =
T12436 37753-37754 FW denotes −
T12437 37754-37759 CD denotes 21.00
T12438 37759-37760 , denotes ,
T12439 37761-37769 NNP denotes Wilcoxon
T12440 37769-37771 POS denotes 's
T12441 37772-37776 NN denotes rank
T12442 37777-37781 NN denotes test
T12443 37781-37782 -RRB- denotes )
T12444 37783-37784 -LRB- denotes (
T12445 37784-37790 NNP denotes Figure
T12446 37791-37793 NNP denotes 7D
T12447 37793-37794 -RRB- denotes )
T12448 37794-37795 . denotes .
T12449 37796-37798 IN denotes In
T12450 37799-37807 NN denotes addition
T12451 37807-37808 , denotes ,
T12452 37809-37811 NNP denotes FP
T12453 37812-37813 -LRB- denotes (
T12454 37813-37816 CD denotes 500
T12455 37817-37819 NN denotes µg
T12456 37819-37820 -RRB- denotes )
T12457 37821-37830 VBD denotes inhibited
T12458 37831-37834 CD denotes p38
T12459 37835-37839 NNP denotes MAPK
T12460 37840-37855 NN denotes phosphorylation
T12461 37856-37858 IN denotes in
T12462 37859-37866 JJ denotes primary
T12463 37867-37868 NNP denotes T
T12464 37869-37874 NNS denotes cells
T12465 37875-37877 IN denotes in
T12466 37878-37882 NN denotes vivo
T12467 37883-37885 IN denotes at
T12468 37886-37887 CD denotes 2
T12469 37888-37889 NN denotes h
T12470 37890-37892 IN denotes in
T12471 37893-37900 NNS denotes samples
T12472 37901-37905 IN denotes from
T12473 37906-37909 CD denotes two
T12474 37910-37918 NNS denotes patients
T12475 37919-37920 -LRB- denotes (
T12476 37920-37926 NN denotes Figure
T12477 37927-37929 CD denotes 7E
T12478 37929-37930 -RRB- denotes )
T12479 37930-37931 . denotes .
T12480 39418-39423 VBN denotes Taken
T12481 39424-39432 RB denotes together
T12482 39432-39433 , denotes ,
T12483 39434-39437 PRP$ denotes our
T12484 39438-39442 NNS denotes data
T12485 39443-39450 VBP denotes suggest
T12486 39451-39455 IN denotes that
T12487 39456-39463 VBD denotes inhaled
T12488 39464-39466 NNP denotes FP
T12489 39467-39474 VBZ denotes reduces
T12490 39475-39482 JJ denotes nuclear
T12491 39483-39495 NN denotes localization
T12492 39496-39498 IN denotes of
T12493 39499-39505 NN denotes GATA-3
T12494 39506-39508 IN denotes in
T12495 39509-39513 NN denotes vivo
T12496 39514-39516 IN denotes by
T12497 39517-39524 RB denotes acutely
T12498 39525-39535 VBG denotes inhibiting
T12499 39536-39550 JJ denotes phospho-GATA-3
T12500 39551-39559 NN denotes importin
T12501 39560-39571 NN denotes association
T12502 39571-39572 . denotes .
T12503 39573-39577 DT denotes This
T12504 39578-39584 NN denotes effect
T12505 39585-39588 MD denotes may
T12506 39589-39591 VB denotes be
T12507 39592-39598 JJ denotes direct
T12508 39598-39599 , denotes ,
T12509 39600-39607 IN denotes through
T12510 39608-39619 NN denotes competition
T12511 39620-39623 IN denotes for
T12512 39624-39634 JJ denotes importin-α
T12513 39635-39637 CC denotes or
T12514 39638-39648 VBN denotes associated
T12515 39649-39658 NNS denotes molecules
T12516 39658-39659 , denotes ,
T12517 39660-39662 CC denotes or
T12518 39663-39672 JJ denotes secondary
T12519 39673-39675 TO denotes to
T12520 39676-39678 DT denotes an
T12521 39679-39685 NN denotes effect
T12522 39686-39688 IN denotes on
T12523 39689-39692 CD denotes p38
T12524 39693-39706 JJ denotes MAPK-mediated
T12525 39707-39713 JJ denotes GATA-3
T12526 39714-39729 NN denotes phosphorylation
T12527 39730-39733 IN denotes via
T12528 39734-39739 JJ denotes rapid
T12529 39740-39749 NN denotes induction
T12530 39750-39752 IN denotes of
T12531 39753-39758 NN denotes MKP-1
T12532 39758-39759 . denotes .
T12533 39760-39763 DT denotes The
T12534 39764-39775 NN denotes combination
T12535 39776-39778 IN denotes of
T12536 39779-39784 DT denotes these
T12537 39785-39788 CD denotes two
T12538 39789-39800 VBG denotes interacting
T12539 39801-39808 NNS denotes effects
T12540 39809-39812 MD denotes can
T12541 39813-39819 VB denotes result
T12542 39820-39822 IN denotes in
T12543 39823-39831 JJ denotes complete
T12544 39832-39843 NN denotes suppression
T12545 39844-39846 IN denotes of
T12546 39847-39853 JJ denotes GATA-3
T12547 39854-39861 JJ denotes nuclear
T12548 39862-39868 NN denotes import
T12549 39869-39872 CC denotes and
T12550 39873-39877 RB denotes thus
T12551 39878-39881 JJ denotes Th2
T12552 39882-39890 NN denotes cytokine
T12553 39891-39895 NN denotes gene
T12554 39896-39906 NN denotes expression
T12555 39906-39907 . denotes .
T14309 39920-39924 RB denotes Here
T14310 39925-39927 PRP denotes we
T14311 39928-39932 VBP denotes have
T14312 39933-39945 VBN denotes demonstrated
T14313 39945-39946 , denotes ,
T14314 39947-39949 TO denotes to
T14315 39950-39953 PRP$ denotes our
T14316 39954-39963 NN denotes knowledge
T14317 39964-39967 IN denotes for
T14318 39968-39971 DT denotes the
T14319 39972-39977 JJ denotes first
T14320 39978-39982 NN denotes time
T14321 39982-39983 , denotes ,
T14322 39984-39988 IN denotes that
T14323 39989-40004 NNS denotes corticosteroids
T14324 40005-40008 MD denotes may
T14325 40009-40016 VB denotes inhibit
T14326 40017-40023 JJ denotes GATA-3
T14327 40024-40032 NN denotes function
T14328 40033-40036 CC denotes and
T14329 40037-40046 RB denotes therefore
T14330 40047-40050 DT denotes the
T14331 40051-40064 NN denotes transcription
T14332 40065-40067 IN denotes of
T14333 40068-40071 JJ denotes Th2
T14334 40072-40077 NNS denotes genes
T14335 40078-40081 IN denotes via
T14336 40082-40085 CD denotes two
T14337 40086-40094 JJ denotes distinct
T14338 40095-40098 CC denotes but
T14339 40099-40110 VBG denotes interacting
T14340 40111-40120 JJ denotes molecular
T14341 40121-40131 NNS denotes mechanisms
T14342 40131-40132 . denotes .
T14343 40133-40140 RB denotes Firstly
T14344 40140-40141 , denotes ,
T14345 40142-40166 JJ denotes corticosteroid-activated
T14346 40167-40169 NNP denotes GR
T14347 40170-40177 VBZ denotes appears
T14348 40178-40180 TO denotes to
T14349 40181-40188 VB denotes compete
T14350 40189-40193 IN denotes with
T14351 40194-40203 VBN denotes activated
T14352 40204-40210 NNP denotes GATA-3
T14353 40211-40214 IN denotes for
T14354 40215-40222 JJ denotes nuclear
T14355 40223-40229 NN denotes import
T14356 40230-40233 IN denotes via
T14357 40234-40244 JJ denotes importin-α
T14358 40244-40245 , denotes ,
T14359 40246-40251 WDT denotes which
T14360 40252-40254 VBZ denotes is
T14361 40255-40263 VBN denotes required
T14362 40264-40267 IN denotes for
T14363 40268-40271 DT denotes the
T14364 40272-40279 JJ denotes nuclear
T14365 40280-40289 NN denotes transport
T14366 40290-40292 IN denotes of
T14367 40293-40297 DT denotes both
T14368 40298-40304 NNP denotes GATA-3
T14369 40305-40308 CC denotes and
T14370 40309-40311 NNP denotes GR
T14371 40311-40312 . denotes .
T14372 40313-40321 RB denotes Secondly
T14373 40321-40322 , denotes ,
T14374 40323-40338 NNS denotes corticosteroids
T14375 40339-40341 IN denotes at
T14376 40342-40348 JJR denotes higher
T14377 40349-40363 NNS denotes concentrations
T14378 40364-40372 VB denotes increase
T14379 40373-40376 DT denotes the
T14380 40377-40387 NN denotes expression
T14381 40388-40390 IN denotes of
T14382 40391-40396 NNP denotes MKP-1
T14383 40396-40397 , denotes ,
T14384 40398-40399 DT denotes a
T14385 40400-40406 JJ denotes potent
T14386 40407-40416 NN denotes inhibitor
T14387 40417-40419 IN denotes of
T14388 40420-40423 CD denotes p38
T14389 40424-40428 NNP denotes MAPK
T14390 40429-40437 NN denotes activity
T14391 40438-40441 CC denotes and
T14392 40442-40449 RB denotes thereby
T14393 40450-40457 VB denotes prevent
T14394 40458-40459 NNP denotes T
T14395 40460-40464 NN denotes cell
T14396 40465-40485 NN denotes receptor/co-receptor
T14397 40486-40496 NN denotes activation
T14398 40497-40499 IN denotes of
T14399 40500-40503 CD denotes p38
T14400 40504-40508 NNP denotes MAPK
T14401 40509-40511 TO denotes to
T14402 40512-40519 VB denotes prevent
T14403 40520-40523 DT denotes the
T14404 40524-40539 NN denotes phosphorylation
T14405 40540-40542 IN denotes of
T14406 40543-40549 NN denotes GATA-3
T14407 40550-40554 WDT denotes that
T14408 40555-40557 VBZ denotes is
T14409 40558-40567 JJ denotes necessary
T14410 40568-40571 IN denotes for
T14411 40572-40583 NN denotes interaction
T14412 40584-40588 IN denotes with
T14413 40589-40599 JJ denotes importin-α
T14414 40600-40603 CC denotes and
T14415 40604-40614 JJ denotes subsequent
T14416 40615-40622 JJ denotes nuclear
T14417 40623-40629 NN denotes import
T14418 40629-40630 . denotes .
T14419 40631-40633 PRP denotes We
T14420 40634-40638 VBP denotes have
T14421 40639-40649 RB denotes previously
T14422 40650-40655 VBN denotes shown
T14423 40656-40660 IN denotes that
T14424 40661-40674 NN denotes translocation
T14425 40675-40677 IN denotes of
T14426 40678-40684 NN denotes GATA-3
T14427 40685-40689 IN denotes from
T14428 40690-40693 DT denotes the
T14429 40694-40703 NN denotes cytoplasm
T14430 40704-40706 TO denotes to
T14431 40707-40710 DT denotes the
T14432 40711-40718 NN denotes nucleus
T14433 40719-40727 VBZ denotes involves
T14434 40728-40731 DT denotes the
T14435 40732-40739 JJ denotes nuclear
T14436 40740-40751 NN denotes transporter
T14437 40752-40759 NN denotes protein
T14438 40760-40770 NN denotes importin-α
T14439 40770-40771 , denotes ,
T14440 40772-40777 WDT denotes which
T14441 40778-40787 VBZ denotes interacts
T14442 40788-40792 IN denotes with
T14443 40793-40807 VBN denotes phosphorylated
T14444 40808-40814 NNP denotes GATA-3
T14445 40815-40816 NNP denotes [
T14446 40816-40818 CD denotes 12
T14447 40818-40819 NNP denotes ]
T14448 40819-40820 . denotes .
T14449 40821-40823 PRP denotes We
T14450 40824-40828 VBP denotes have
T14451 40829-40833 RB denotes also
T14452 40834-40844 RB denotes previously
T14453 40845-40853 VBN denotes reported
T14454 40854-40858 IN denotes that
T14455 40859-40865 JJ denotes GATA-3
T14456 40866-40875 NN denotes knockdown
T14457 40876-40881 VBG denotes using
T14458 40882-40887 NNP denotes siRNA
T14459 40888-40895 NNS denotes results
T14460 40896-40898 IN denotes in
T14461 40899-40910 NN denotes suppression
T14462 40911-40913 IN denotes of
T14463 40914-40922 JJ denotes anti-CD3
T14464 40922-40923 NN denotes /
T14465 40923-40927 CD denotes CD28
T14466 40928-40938 VBD denotes stimulated
T14467 40939-40943 NN denotes IL-4
T14468 40943-40944 NN denotes /
T14469 40944-40948 NN denotes IL-5
T14470 40949-40953 NNP denotes mRNA
T14471 40954-40963 NN denotes induction
T14472 40963-40964 , denotes ,
T14473 40965-40969 RB denotes thus
T14474 40970-40981 VBG denotes implicating
T14475 40982-40984 DT denotes an
T14476 40985-40994 JJ denotes essential
T14477 40995-40999 NN denotes role
T14478 41000-41003 IN denotes for
T14479 41004-41010 NNP denotes GATA-3
T14480 41011-41013 IN denotes in
T14481 41014-41017 DT denotes the
T14482 41018-41031 NN denotes transcription
T14483 41032-41034 IN denotes of
T14484 41035-41040 DT denotes these
T14485 41041-41046 NNS denotes genes
T14486 41047-41048 NNP denotes [
T14487 41048-41050 CD denotes 12
T14488 41050-41051 NNP denotes ]
T14489 41051-41052 . denotes .
T14490 41053-41055 PRP denotes We
T14491 41056-41059 RB denotes now
T14492 41060-41067 VBP denotes confirm
T14493 41067-41068 , denotes ,
T14494 41069-41071 IN denotes in
T14495 41072-41077 JJ denotes human
T14496 41078-41079 NNP denotes T
T14497 41080-41085 NNS denotes cells
T14498 41085-41086 , denotes ,
T14499 41087-41091 IN denotes that
T14500 41092-41094 NNP denotes GR
T14501 41095-41099 RB denotes also
T14502 41100-41104 VBZ denotes uses
T14503 41105-41108 DT denotes the
T14504 41109-41113 JJ denotes same
T14505 41114-41121 JJ denotes nuclear
T14506 41122-41128 NN denotes import
T14507 41129-41138 NN denotes mechanism
T14508 41139-41141 IN denotes as
T14509 41142-41148 JJ denotes GATA-3
T14510 41149-41150 NNP denotes [
T14511 41150-41152 CD denotes 22
T14512 41152-41153 NNP denotes ]
T14513 41153-41154 . denotes .
T14514 41155-41157 PRP denotes We
T14515 41158-41167 RB denotes therefore
T14516 41168-41175 VBP denotes propose
T14517 41176-41180 IN denotes that
T14518 41181-41186 EX denotes there
T14519 41187-41189 VBZ denotes is
T14520 41190-41201 NN denotes competition
T14521 41202-41209 IN denotes between
T14522 41210-41226 JJ denotes ligand-activated
T14523 41227-41229 NNP denotes GR
T14524 41230-41233 CC denotes and
T14525 41234-41248 NNP denotes phospho-GATA-3
T14526 41249-41252 IN denotes for
T14527 41253-41260 JJ denotes nuclear
T14528 41261-41267 NN denotes import
T14529 41267-41268 . denotes .
T14530 41269-41280 RB denotes Furthermore
T14531 41280-41281 , denotes ,
T14532 41282-41284 PRP denotes we
T14533 41285-41289 VBP denotes have
T14534 41290-41295 VBN denotes shown
T14535 41296-41300 IN denotes that
T14536 41301-41306 EX denotes there
T14537 41307-41309 VBZ denotes is
T14538 41310-41322 JJ denotes preferential
T14539 41323-41330 JJ denotes binding
T14540 41331-41333 IN denotes of
T14541 41334-41344 JJ denotes importin-α
T14542 41345-41347 TO denotes to
T14543 41348-41357 VBN denotes activated
T14544 41358-41360 NNP denotes GR
T14545 41361-41365 IN denotes over
T14546 41366-41380 NNP denotes phospho-GATA-3
T14547 41380-41381 , denotes ,
T14548 41382-41384 RB denotes so
T14549 41385-41389 IN denotes that
T14550 41390-41405 NNS denotes corticosteroids
T14551 41406-41411 MD denotes would
T14552 41412-41426 RB denotes preferentially
T14553 41427-41433 VB denotes reduce
T14554 41434-41440 JJ denotes GATA-3
T14555 41441-41446 NN denotes entry
T14556 41447-41450 CC denotes and
T14557 41451-41455 RB denotes thus
T14558 41456-41463 RB denotes rapidly
T14559 41464-41470 VB denotes switch
T14560 41471-41474 RP denotes off
T14561 41475-41478 CD denotes Th2
T14562 41479-41483 NN denotes gene
T14563 41484-41497 NN denotes transcription
T14564 41498-41505 IN denotes without
T14565 41506-41509 DT denotes any
T14566 41510-41514 NN denotes need
T14567 41515-41518 IN denotes for
T14568 41519-41522 DT denotes any
T14569 41523-41535 JJ denotes intermediate
T14570 41536-41541 NNS denotes steps
T14571 41541-41542 . denotes .
T14572 41543-41554 RB denotes Furthermore
T14573 41554-41555 , denotes ,
T14574 41556-41561 EX denotes there
T14575 41562-41565 VBD denotes was
T14576 41566-41570 DT denotes some
T14577 41571-41577 NN denotes degree
T14578 41578-41580 IN denotes of
T14579 41581-41592 NN denotes specificity
T14580 41593-41596 IN denotes for
T14581 41597-41603 NNP denotes GATA-3
T14582 41603-41604 , denotes ,
T14583 41605-41607 IN denotes as
T14584 41608-41615 JJ denotes nuclear
T14585 41616-41629 NN denotes translocation
T14586 41630-41632 IN denotes of
T14587 41633-41636 DT denotes the
T14588 41637-41640 CD denotes p65
T14589 41641-41648 NN denotes subunit
T14590 41649-41651 IN denotes of
T14591 41652-41657 NN denotes NF-κB
T14592 41658-41661 VBD denotes was
T14593 41662-41665 RB denotes not
T14594 41666-41674 VBN denotes affected
T14595 41675-41677 IN denotes by
T14596 41678-41692 JJ denotes corticosteroid
T14597 41693-41701 NN denotes exposure
T14598 41701-41702 . denotes .
T14599 41703-41705 PRP denotes We
T14600 41706-41712 VBD denotes tested
T14601 41713-41717 DT denotes some
T14602 41718-41729 JJ denotes alternative
T14603 41730-41742 NNS denotes explanations
T14604 41743-41746 IN denotes for
T14605 41747-41751 DT denotes this
T14606 41752-41758 NN denotes effect
T14607 41759-41761 IN denotes of
T14608 41762-41764 NNP denotes FP
T14609 41765-41767 IN denotes on
T14610 41768-41774 NNP denotes GATA-3
T14611 41775-41782 JJ denotes nuclear
T14612 41783-41792 NN denotes exclusion
T14613 41793-41796 CC denotes and
T14614 41797-41803 VBD denotes failed
T14615 41804-41806 TO denotes to
T14616 41807-41811 VB denotes show
T14617 41812-41816 IN denotes that
T14618 41817-41819 NNP denotes FP
T14619 41820-41826 CC denotes either
T14620 41827-41835 VBZ denotes enhances
T14621 41836-41842 JJ denotes GATA-3
T14622 41843-41850 JJ denotes nuclear
T14623 41851-41857 NN denotes export
T14624 41858-41866 RB denotes directly
T14625 41867-41869 CC denotes or
T14626 41870-41877 VBZ denotes induces
T14627 41878-41884 JJ denotes GATA-3
T14628 41885-41896 NN denotes degradation
T14629 41896-41897 . denotes .
T14630 41898-41901 DT denotes The
T14631 41902-41910 NN denotes evidence
T14632 41911-41915 IN denotes from
T14633 41916-41919 DT denotes the
T14634 41920-41922 IN denotes in
T14635 41923-41928 NN denotes vitro
T14636 41929-41940 NN denotes competition
T14637 41941-41947 VBZ denotes assays
T14638 41948-41952 VBZ denotes does
T14639 41952-41953 , denotes ,
T14640 41954-41961 RB denotes however
T14641 41961-41962 , denotes ,
T14642 41963-41970 VBP denotes suggest
T14643 41971-41975 IN denotes that
T14644 41976-41984 JJ denotes purified
T14645 41985-41994 VBN denotes activated
T14646 41995-41997 NNP denotes GR
T14647 41998-42001 MD denotes can
T14648 42002-42009 RB denotes clearly
T14649 42010-42019 VB denotes attenuate
T14650 42020-42028 VBN denotes purified
T14651 42029-42043 JJ denotes phospho-GATA-3
T14652 42044-42054 JJ denotes importin-α
T14653 42055-42066 NN denotes association
T14654 42067-42070 CC denotes and
T14655 42071-42075 IN denotes that
T14656 42076-42079 DT denotes the
T14657 42080-42088 NN denotes converse
T14658 42089-42093 VBZ denotes does
T14659 42094-42097 RB denotes not
T14660 42098-42103 VB denotes occur
T14661 42103-42104 . denotes .
T14662 42105-42116 RB denotes Furthermore
T14663 42116-42117 , denotes ,
T14664 42118-42120 PRP denotes we
T14665 42121-42125 VBP denotes have
T14666 42126-42131 VBN denotes shown
T14667 42132-42136 IN denotes that
T14668 42137-42141 RB denotes only
T14669 42142-42156 JJ denotes phospho-GATA-3
T14670 42157-42160 MD denotes can
T14671 42161-42170 VB denotes associate
T14672 42171-42175 IN denotes with
T14673 42176-42186 JJ denotes importin-α
T14674 42186-42187 . denotes .
T14675 42188-42192 DT denotes This
T14676 42193-42202 NN denotes mechanism
T14677 42203-42205 VBZ denotes is
T14678 42206-42215 JJ denotes sensitive
T14679 42216-42218 TO denotes to
T14680 42219-42223 RB denotes very
T14681 42224-42227 JJ denotes low
T14682 42228-42242 NNS denotes concentrations
T14683 42243-42245 IN denotes of
T14684 42246-42260 JJ denotes corticosteroid
T14685 42261-42264 CC denotes and
T14686 42265-42270 MD denotes would
T14687 42271-42273 VB denotes be
T14688 42274-42279 JJ denotes rapid
T14689 42280-42282 IN denotes in
T14690 42283-42288 NN denotes onset
T14691 42289-42291 IN denotes as
T14692 42292-42294 DT denotes no
T14693 42295-42302 NNS denotes changes
T14694 42303-42305 IN denotes in
T14695 42306-42313 NN denotes protein
T14696 42314-42323 NN denotes synthesis
T14697 42324-42327 VBP denotes are
T14698 42328-42336 VBN denotes required
T14699 42336-42337 . denotes .
T14700 42338-42342 DT denotes This
T14701 42343-42348 JJ denotes acute
T14702 42349-42358 NN denotes mechanism
T14703 42359-42362 MD denotes may
T14704 42363-42367 RB denotes also
T14705 42368-42378 VB denotes contribute
T14706 42379-42381 TO denotes to
T14707 42382-42385 DT denotes the
T14708 42386-42395 NN denotes reduction
T14709 42396-42398 IN denotes in
T14710 42399-42405 JJ denotes GATA-3
T14711 42406-42413 JJ denotes nuclear
T14712 42414-42420 NN denotes import
T14713 42421-42424 CC denotes and
T14714 42425-42428 MD denotes may
T14715 42429-42433 VB denotes play
T14716 42434-42435 DT denotes a
T14717 42436-42441 JJ denotes major
T14718 42442-42446 NN denotes role
T14719 42447-42449 IN denotes at
T14720 42450-42453 JJ denotes low
T14721 42454-42468 JJ denotes corticosteroid
T14722 42469-42483 NNS denotes concentrations
T14723 42484-42490 CC denotes and/or
T14724 42491-42493 IN denotes at
T14725 42494-42499 JJ denotes early
T14726 42500-42504 NN denotes time
T14727 42505-42511 NNS denotes points
T14728 42512-42517 RB denotes prior
T14729 42518-42520 TO denotes to
T14730 42521-42526 NNP denotes MKP-1
T14731 42527-42536 NN denotes induction
T14732 42536-42537 . denotes .
T14733 42538-42553 NNS denotes Corticosteroids
T14734 42554-42557 MD denotes can
T14735 42558-42566 VB denotes modulate
T14736 42567-42570 CD denotes p38
T14737 42571-42575 NNP denotes MAPK
T14738 42576-42584 NN denotes activity
T14739 42585-42592 IN denotes through
T14740 42593-42596 DT denotes the
T14741 42597-42606 NN denotes induction
T14742 42607-42609 IN denotes of
T14743 42610-42615 NNP denotes MKP-1
T14744 42615-42616 , denotes ,
T14745 42617-42618 DT denotes a
T14746 42619-42625 JJ denotes potent
T14747 42626-42636 JJ denotes endogenous
T14748 42637-42646 NN denotes inhibitor
T14749 42647-42649 IN denotes of
T14750 42650-42654 NNP denotes MAPK
T14751 42655-42663 NN denotes function
T14752 42664-42665 NNP denotes [
T14753 42665-42667 CD denotes 38
T14754 42667-42668 NNP denotes ]
T14755 42668-42669 , denotes ,
T14756 42669-42670 NNP denotes [
T14757 42670-42672 CD denotes 39
T14758 42672-42673 NNP denotes ]
T14759 42673-42674 . denotes .
T14760 42675-42677 PRP denotes We
T14761 42678-42684 VBP denotes report
T14762 42685-42689 RB denotes here
T14763 42690-42691 DT denotes a
T14764 42692-42697 JJ denotes rapid
T14765 42698-42707 NN denotes induction
T14766 42708-42710 IN denotes of
T14767 42711-42716 NNP denotes MKP-1
T14768 42717-42721 NNP denotes mRNA
T14769 42722-42731 VBG denotes following
T14770 42732-42743 NN denotes stimulation
T14771 42744-42746 IN denotes of
T14772 42747-42752 NNS denotes cells
T14773 42753-42757 IN denotes with
T14774 42758-42768 RB denotes relatively
T14775 42769-42773 JJ denotes high
T14776 42774-42788 NNS denotes concentrations
T14777 42789-42791 IN denotes of
T14778 42792-42794 NNP denotes FP
T14779 42794-42795 . denotes .
T14780 42796-42798 PRP denotes We
T14781 42799-42810 VBP denotes hypothesize
T14782 42811-42815 IN denotes that
T14783 42816-42820 DT denotes this
T14784 42821-42826 JJ denotes rapid
T14785 42827-42836 NN denotes induction
T14786 42837-42839 IN denotes of
T14787 42840-42845 NN denotes MKP-1
T14788 42846-42849 MD denotes can
T14789 42850-42856 VB denotes reduce
T14790 42857-42863 JJ denotes GATA-3
T14791 42864-42871 JJ denotes nuclear
T14792 42872-42878 NN denotes import
T14793 42879-42881 IN denotes by
T14794 42882-42893 VBG denotes attenuating
T14795 42894-42897 CD denotes p38
T14796 42898-42902 NNP denotes MAPK
T14797 42903-42911 NN denotes activity
T14798 42912-42915 CC denotes and
T14799 42916-42926 JJ denotes subsequent
T14800 42927-42933 NN denotes GATA-3
T14801 42934-42949 NN denotes phosphorylation
T14802 42949-42950 , denotes ,
T14803 42951-42955 RB denotes thus
T14804 42956-42966 VBG denotes preventing
T14805 42967-42974 JJ denotes nuclear
T14806 42975-42988 NN denotes translocation
T14807 42988-42989 . denotes .
T14808 42990-42993 DT denotes The
T14809 42994-43002 NN denotes location
T14810 43003-43005 IN denotes of
T14811 43006-43009 DT denotes the
T14812 43010-43016 NN denotes serine
T14813 43017-43024 NN denotes residue
T14814 43024-43025 -LRB- denotes (
T14815 43025-43026 PRP denotes s
T14816 43026-43027 -RRB- denotes )
T14817 43028-43030 IN denotes of
T14818 43031-43037 NN denotes GATA-3
T14819 43038-43042 WDT denotes that
T14820 43043-43046 VBP denotes are
T14821 43047-43061 VBN denotes phosphorylated
T14822 43062-43064 IN denotes by
T14823 43065-43068 CD denotes p38
T14824 43069-43073 NNP denotes MAPK
T14825 43074-43077 VBP denotes are
T14826 43078-43087 RB denotes currently
T14827 43088-43095 JJ denotes unknown
T14828 43095-43096 , denotes ,
T14829 43097-43100 CC denotes but
T14830 43101-43102 DT denotes a
T14831 43103-43117 NNS denotes bioinformatics
T14832 43118-43124 NN denotes search
T14833 43125-43126 -LRB- denotes (
T14834 43126-43131 NNP denotes Motif
T14835 43132-43139 NNP denotes Scanner
T14836 43139-43140 , denotes ,
T14837 43141-43184 NNP denotes http://scansite.mit.edu/motifscan_seq.phtml
T14838 43184-43185 -RRB- denotes )
T14839 43186-43195 VBZ denotes indicates
T14840 43196-43198 IN denotes at
T14841 43199-43204 JJS denotes least
T14842 43205-43210 CD denotes three
T14843 43211-43220 JJ denotes potential
T14844 43221-43224 CD denotes p38
T14845 43225-43239 JJ denotes MAPK-sensitive
T14846 43240-43246 NN denotes serine
T14847 43247-43255 NNS denotes residues
T14848 43255-43256 . denotes .
T14849 43257-43259 IN denotes As
T14850 43260-43269 VBN denotes predicted
T14851 43270-43274 IN denotes from
T14852 43275-43280 DT denotes these
T14853 43281-43283 IN denotes in
T14854 43284-43289 NN denotes vitro
T14855 43290-43294 NNS denotes data
T14856 43294-43295 , denotes ,
T14857 43296-43306 NN denotes impairment
T14858 43307-43309 IN denotes of
T14859 43310-43316 JJ denotes GATA-3
T14860 43317-43324 JJ denotes nuclear
T14861 43325-43331 NN denotes import
T14862 43332-43334 IN denotes by
T14863 43335-43337 NNP denotes FP
T14864 43338-43341 MD denotes may
T14865 43341-43342 , denotes ,
T14866 43343-43345 IN denotes at
T14867 43346-43351 JJS denotes least
T14868 43352-43354 IN denotes in
T14869 43355-43359 NN denotes part
T14870 43359-43360 , denotes ,
T14871 43361-43369 VBP denotes underlie
T14872 43370-43373 DT denotes the
T14873 43374-43382 NN denotes efficacy
T14874 43383-43385 IN denotes of
T14875 43386-43401 NNS denotes corticosteroids
T14876 43402-43404 IN denotes in
T14877 43405-43416 VBG denotes suppressing
T14878 43417-43425 JJ denotes allergic
T14879 43426-43438 NN denotes inflammation
T14880 43438-43439 . denotes .
T14881 43440-43448 IN denotes Although
T14882 43449-43451 PRP denotes we
T14883 43452-43455 VBD denotes did
T14884 43456-43459 RB denotes not
T14885 43460-43466 VB denotes assess
T14886 43467-43470 DT denotes the
T14887 43471-43476 JJ denotes acute
T14888 43477-43487 JJ denotes inhibitory
T14889 43488-43494 NN denotes effect
T14890 43495-43497 IN denotes of
T14891 43498-43500 NNP denotes FP
T14892 43501-43503 IN denotes on
T14893 43504-43507 DT denotes the
T14894 43508-43518 NN denotes expression
T14895 43519-43521 IN denotes of
T14896 43522-43526 NN denotes IL-4
T14897 43527-43531 NNP denotes mRNA
T14898 43532-43534 IN denotes in
T14899 43535-43539 NN denotes vivo
T14900 43539-43540 , denotes ,
T14901 43541-43542 DT denotes a
T14902 43543-43549 JJ denotes single
T14903 43550-43560 NN denotes inhalation
T14904 43561-43563 IN denotes of
T14905 43564-43566 NNP denotes FP
T14906 43567-43568 -LRB- denotes (
T14907 43568-43571 CD denotes 500
T14908 43572-43574 NN denotes µg
T14909 43574-43575 -RRB- denotes )
T14910 43576-43579 MD denotes may
T14911 43580-43584 VB denotes have
T14912 43585-43595 JJ denotes comparable
T14913 43596-43603 NNS denotes effects
T14914 43603-43604 , denotes ,
T14915 43605-43607 IN denotes as
T14916 43608-43610 PRP denotes it
T14917 43611-43619 VBZ denotes provides
T14918 43620-43626 NN denotes plasma
T14919 43627-43633 NNS denotes levels
T14920 43634-43640 IN denotes within
T14921 43641-43642 DT denotes a
T14922 43643-43651 JJ denotes relevant
T14923 43652-43657 NN denotes range
T14924 43658-43660 IN denotes of
T14925 43661-43675 NNS denotes concentrations
T14926 43676-43680 VBN denotes used
T14927 43681-43683 TO denotes to
T14928 43684-43692 VB denotes suppress
T14929 43693-43697 NN denotes IL-4
T14930 43698-43711 NN denotes transcription
T14931 43712-43714 IN denotes in
T14932 43715-43718 PRP$ denotes our
T14933 43719-43721 IN denotes in
T14934 43722-43727 NN denotes vitro
T14935 43728-43734 NN denotes system
T14936 43735-43736 NNP denotes [
T14937 43736-43738 CD denotes 37
T14938 43738-43739 NNP denotes ]
T14939 43739-43740 . denotes .
T14940 43741-43742 DT denotes A
T14941 43743-43748 JJR denotes lower
T14942 43749-43753 NN denotes dose
T14943 43754-43756 IN denotes of
T14944 43757-43764 JJ denotes inhaled
T14945 43765-43767 NNP denotes FP
T14946 43768-43769 -LRB- denotes (
T14947 43769-43772 CD denotes 100
T14948 43773-43775 NN denotes µg
T14949 43775-43776 -RRB- denotes )
T14950 43777-43780 VBD denotes was
T14951 43781-43784 RB denotes not
T14952 43785-43794 JJ denotes effective
T14953 43794-43795 , denotes ,
T14954 43796-43799 CC denotes but
T14955 43800-43806 NN denotes plasma
T14956 43807-43821 NNS denotes concentrations
T14957 43822-43825 MD denotes may
T14958 43826-43828 VB denotes be
T14959 43829-43834 IN denotes below
T14960 43835-43840 DT denotes those
T14961 43841-43849 VBN denotes required
T14962 43850-43853 IN denotes for
T14963 43854-43860 JJ denotes GATA-3
T14964 43861-43871 NN denotes inhibition
T14965 43871-43872 . denotes .
T14966 43873-43880 RB denotes However
T14967 43880-43881 , denotes ,
T14968 43882-43884 PRP denotes it
T14969 43885-43887 VBZ denotes is
T14970 43888-43894 JJ denotes likely
T14971 43895-43899 IN denotes that
T14972 43900-43903 DT denotes the
T14973 43904-43910 JJR denotes higher
T14974 43911-43925 NNS denotes concentrations
T14975 43926-43928 IN denotes of
T14976 43929-43931 NNP denotes FP
T14977 43932-43934 IN denotes in
T14978 43935-43938 DT denotes the
T14979 43939-43946 NNS denotes airways
T14980 43947-43952 IN denotes after
T14981 43953-43960 JJ denotes inhaled
T14982 43961-43975 NN denotes administration
T14983 43976-43981 MD denotes would
T14984 43982-43984 VB denotes be
T14985 43985-43994 JJ denotes effective
T14986 43995-43997 IN denotes in
T14987 43998-44008 VBG denotes inhibiting
T14988 44009-44015 NN denotes GATA-3
T14989 44016-44018 IN denotes in
T14990 44019-44025 NN denotes airway
T14991 44026-44027 NNP denotes T
T14992 44028-44033 NNS denotes cells
T14993 44034-44036 IN denotes of
T14994 44037-44043 NN denotes asthma
T14995 44044-44052 NNS denotes patients
T14996 44052-44053 . denotes .
T14997 44054-44057 DT denotes The
T14998 44058-44063 NN denotes study
T14999 44064-44066 IN denotes of
T15000 44067-44072 NNS denotes PBMCs
T15001 44073-44077 IN denotes from
T15002 44078-44084 NN denotes asthma
T15003 44085-44093 NNS denotes patients
T15004 44094-44101 VBN denotes treated
T15005 44102-44106 IN denotes with
T15006 44107-44114 JJ denotes inhaled
T15007 44115-44129 JJ denotes corticosteroid
T15008 44130-44137 NN denotes therapy
T15009 44138-44145 RB denotes clearly
T15010 44146-44158 VBZ denotes demonstrates
T15011 44159-44163 IN denotes that
T15012 44164-44169 DT denotes these
T15013 44170-44179 JJ denotes molecular
T15014 44180-44190 NNS denotes mechanisms
T15015 44191-44194 VBP denotes are
T15016 44195-44201 JJ denotes likely
T15017 44202-44204 TO denotes to
T15018 44205-44209 RB denotes also
T15019 44210-44215 VB denotes occur
T15020 44216-44218 IN denotes in
T15021 44219-44227 NNS denotes patients
T15022 44228-44230 IN denotes at
T15023 44231-44242 JJ denotes therapeutic
T15024 44243-44248 NNS denotes doses
T15025 44249-44251 IN denotes of
T15026 44252-44259 JJ denotes inhaled
T15027 44260-44275 NNS denotes corticosteroids
T15028 44275-44276 . denotes .
T15029 44277-44279 IN denotes In
T15030 44280-44288 NN denotes addition
T15031 44288-44289 , denotes ,
T15032 44290-44298 JJ denotes previous
T15033 44299-44306 NNS denotes studies
T15034 44307-44311 VBP denotes have
T15035 44312-44317 VBN denotes shown
T15036 44318-44322 IN denotes that
T15037 44323-44338 NNS denotes corticosteroids
T15038 44339-44342 MD denotes can
T15039 44343-44351 VB denotes suppress
T15040 44352-44356 NN denotes IL-4
T15041 44357-44360 CC denotes and
T15042 44361-44365 NN denotes IL-5
T15043 44366-44373 NN denotes release
T15044 44374-44378 IN denotes from
T15045 44379-44389 JJ denotes peripheral
T15046 44390-44395 NN denotes blood
T15047 44396-44401 NNS denotes cells
T15048 44402-44404 IN denotes of
T15049 44405-44411 NN denotes asthma
T15050 44412-44420 NNS denotes patients
T15051 44421-44423 IN denotes in
T15052 44424-44429 NN denotes vitro
T15053 44430-44433 CC denotes and
T15054 44434-44436 IN denotes in
T15055 44437-44441 NN denotes vivo
T15056 44442-44443 NNP denotes [
T15057 44443-44445 CD denotes 40
T15058 44445-44446 NNP denotes ]
T15059 44447-44448 NNP denotes [
T15060 44448-44450 CD denotes 42
T15061 44450-44451 NNP denotes ]
T15062 44451-44452 . denotes .
T15063 44453-44455 IN denotes In
T15064 44456-44463 NN denotes summary
T15065 44463-44464 , denotes ,
T15066 44465-44468 PRP$ denotes our
T15067 44469-44473 NNS denotes data
T15068 44474-44481 VBP denotes provide
T15069 44482-44490 NN denotes evidence
T15070 44491-44494 IN denotes for
T15071 44495-44496 DT denotes a
T15072 44497-44502 NN denotes novel
T15073 44503-44509 NN denotes action
T15074 44510-44512 IN denotes of
T15075 44513-44528 NNS denotes corticosteroids
T15076 44528-44529 : denotes :
T15077 44530-44541 NN denotes suppression
T15078 44542-44544 IN denotes of
T15079 44545-44553 JJ denotes allergic
T15080 44554-44566 NN denotes inflammation
T15081 44567-44574 IN denotes through
T15082 44575-44576 DT denotes a
T15083 44577-44582 JJ denotes rapid
T15084 44583-44593 JJ denotes inhibitory
T15085 44594-44600 NN denotes effect
T15086 44601-44603 IN denotes on
T15087 44604-44610 JJ denotes GATA-3
T15088 44611-44618 JJ denotes nuclear
T15089 44619-44632 NN denotes translocation
T15090 44633-44635 IN denotes by
T15091 44636-44648 JJ denotes preferential
T15092 44649-44656 JJ denotes binding
T15093 44657-44659 TO denotes to
T15094 44660-44663 DT denotes the
T15095 44664-44670 VBN denotes shared
T15096 44671-44678 JJ denotes nuclear
T15097 44679-44685 NN denotes import
T15098 44686-44693 NN denotes protein
T15099 44694-44704 NN denotes importin-α
T15100 44705-44708 CC denotes and
T15101 44709-44711 IN denotes by
T15102 44712-44713 DT denotes a
T15103 44714-44720 JJ denotes second
T15104 44721-44730 NN denotes mechanism
T15105 44731-44740 VBG denotes involving
T15106 44741-44750 VBN denotes increased
T15107 44751-44760 NN denotes synthesis
T15108 44761-44763 IN denotes of
T15109 44764-44769 NNP denotes MKP-1
T15110 44769-44770 , denotes ,
T15111 44771-44776 WDT denotes which
T15112 44777-44785 VBZ denotes inhibits
T15113 44786-44789 CD denotes p38
T15114 44790-44794 NNP denotes MAPK
T15115 44794-44795 , denotes ,
T15116 44796-44800 RB denotes thus
T15117 44801-44811 VBG denotes preventing
T15118 44812-44815 DT denotes the
T15119 44816-44831 NN denotes phosphorylation
T15120 44832-44834 IN denotes of
T15121 44835-44841 NN denotes GATA-3
T15122 44842-44846 WDT denotes that
T15123 44847-44849 VBZ denotes is
T15124 44850-44859 JJ denotes necessary
T15125 44860-44863 IN denotes for
T15126 44864-44871 JJ denotes nuclear
T15127 44872-44885 NN denotes translocation
T15128 44886-44888 IN denotes of
T15129 44889-44895 NN denotes GATA-3
T15130 44895-44896 . denotes .
T15131 44897-44902 DT denotes These
T15132 44903-44906 CD denotes two
T15133 44907-44917 NNS denotes mechanisms
T15134 44918-44921 VBP denotes are
T15135 44922-44928 JJ denotes likely
T15136 44929-44931 TO denotes to
T15137 44932-44934 VB denotes be
T15138 44935-44946 JJ denotes synergistic
T15139 44946-44947 , denotes ,
T15140 44948-44958 VBG denotes accounting
T15141 44959-44962 IN denotes for
T15142 44963-44966 DT denotes the
T15143 44967-44972 JJ denotes rapid
T15144 44973-44976 CC denotes and
T15145 44977-44983 JJ denotes potent
T15146 44984-44990 NN denotes effect
T15147 44991-44993 IN denotes of
T15148 44994-45009 NNS denotes corticosteroids
T15149 45010-45012 IN denotes on
T15150 45013-45021 JJ denotes allergic
T15151 45022-45034 NN denotes inflammation
T15152 45034-45035 . denotes .
T15153 45036-45040 DT denotes This
T15154 45041-45043 VBZ denotes is
T15155 45044-45055 VBN denotes exemplified
T15156 45056-45058 IN denotes by
T15157 45059-45062 DT denotes the
T15158 45063-45068 JJ denotes rapid
T15159 45069-45079 JJ denotes inhibitory
T15160 45080-45086 NN denotes effect
T15161 45087-45089 IN denotes of
T15162 45090-45097 JJ denotes topical
T15163 45098-45113 NNS denotes corticosteroids
T15164 45114-45116 IN denotes on
T15165 45117-45122 JJ denotes nasal
T15166 45123-45126 JJ denotes Th2
T15167 45127-45135 NN denotes cytokine
T15168 45136-45143 NN denotes release
T15169 45144-45149 IN denotes after
T15170 45150-45158 NN denotes allergen
T15171 45159-45170 NN denotes provocation
T15172 45171-45173 IN denotes in
T15173 45174-45185 NNS denotes individuals
T15174 45186-45190 IN denotes with
T15175 45191-45199 JJ denotes seasonal
T15176 45200-45208 JJ denotes allergic
T15177 45209-45217 NN denotes rhinitis
T15178 45218-45219 -LRB- denotes (
T15179 45219-45222 NN denotes hay
T15180 45223-45228 NN denotes fever
T15181 45228-45229 -RRB- denotes )
T15182 45230-45231 NNP denotes [
T15183 45231-45233 CD denotes 43
T15184 45233-45234 NNP denotes ]
T15185 45234-45235 . denotes .
T15186 45236-45246 NNP denotes Prevention
T15187 45247-45249 IN denotes of
T15188 45250-45264 JJ denotes phospho-GATA-3
T15189 45265-45276 NN denotes interaction
T15190 45277-45281 IN denotes with
T15191 45282-45292 NN denotes importin-α
T15192 45293-45296 MD denotes may
T15193 45297-45304 VB denotes provide
T15194 45305-45306 DT denotes a
T15195 45307-45310 JJ denotes new
T15196 45311-45319 NN denotes approach
T15197 45320-45323 IN denotes for
T15198 45324-45327 DT denotes the
T15199 45328-45339 NN denotes development
T15200 45340-45342 IN denotes of
T15201 45343-45348 NN denotes novel
T15202 45349-45358 NNS denotes therapies
T15203 45359-45362 IN denotes for
T15204 45363-45366 DT denotes the
T15205 45367-45376 NN denotes treatment
T15206 45377-45379 IN denotes of
T15207 45380-45388 JJ denotes allergic
T15208 45389-45397 NNS denotes diseases
T15209 45397-45398 . denotes .
T16315 24319-24330 NNP denotes Fluticasone
T16316 24331-24341 JJ denotes propionate
T16317 24342-24356 NNS denotes down-regulates
T16318 24357-24360 JJ denotes Th2
T16319 24361-24369 NN denotes cytokine
T16320 24370-24374 NN denotes gene
T16321 24375-24385 NN denotes expression
T16322 24386-24389 CC denotes and
T16323 24390-24398 NNS denotes inhibits
T16324 24399-24405 JJ denotes GATA-3
T16325 24406-24413 JJ denotes nuclear
T16326 24414-24420 NN denotes import
T16327 24420-24421 . denotes .
T16328 24422-24423 -LRB- denotes (
T16329 24423-24424 NNP denotes A
T16330 24424-24425 -RRB- denotes )
T16331 24426-24434 JJ denotes Anti-CD3
T16332 24434-24435 NN denotes /
T16333 24435-24439 CD denotes CD28
T16334 24440-24449 NN denotes treatment
T16335 24450-24452 IN denotes of
T16336 24453-24459 JJ denotes HuT-78
T16337 24460-24465 NNS denotes cells
T16338 24466-24473 NNS denotes results
T16339 24474-24476 IN denotes in
T16340 24477-24490 NN denotes translocation
T16341 24491-24493 IN denotes of
T16342 24494-24500 NN denotes GATA-3
T16343 24501-24505 IN denotes from
T16344 24506-24509 DT denotes the
T16345 24510-24519 NN denotes cytoplasm
T16346 24520-24522 TO denotes to
T16347 24523-24526 DT denotes the
T16348 24527-24534 NN denotes nucleus
T16349 24535-24541 IN denotes within
T16350 24542-24544 CD denotes 30
T16351 24545-24548 NN denotes min
T16352 24548-24549 . denotes .
T16353 24550-24551 -LRB- denotes (
T16354 24551-24552 NNP denotes B
T16355 24552-24553 -RRB- denotes )
T16356 24554-24561 NNP denotes Histone
T16357 24562-24564 NNP denotes H1
T16358 24565-24568 CC denotes and
T16359 24569-24574 NNP denotes MEK-1
T16360 24575-24579 VBD denotes were
T16361 24580-24584 VBN denotes used
T16362 24585-24587 TO denotes to
T16363 24588-24595 VB denotes confirm
T16364 24596-24604 JJ denotes distinct
T16365 24605-24615 NN denotes separation
T16366 24616-24618 IN denotes of
T16367 24619-24630 JJ denotes cytoplasmic
T16368 24631-24634 CC denotes and
T16369 24635-24642 JJ denotes nuclear
T16370 24643-24651 NNS denotes extracts
T16371 24652-24654 IN denotes in
T16372 24655-24660 CD denotes three
T16373 24661-24669 JJ denotes separate
T16374 24670-24681 NNS denotes experiments
T16375 24681-24682 . denotes .
T16376 24683-24684 -LRB- denotes (
T16377 24684-24685 $ denotes C
T16378 24685-24686 -RRB- denotes )
T16379 24687-24694 JJ denotes Western
T16380 24695-24699 NN denotes blot
T16381 24700-24708 NN denotes analysis
T16382 24709-24711 IN denotes of
T16383 24712-24722 JJ denotes FP-treated
T16384 24723-24729 JJ denotes HuT-78
T16385 24730-24735 NNS denotes cells
T16386 24736-24748 VBD denotes demonstrated
T16387 24749-24757 VBN denotes impaired
T16388 24758-24765 JJ denotes nuclear
T16389 24766-24778 NN denotes localization
T16390 24779-24781 IN denotes of
T16391 24782-24788 JJ denotes GATA-3
T16392 24789-24796 VBN denotes induced
T16393 24797-24799 IN denotes by
T16394 24800-24808 JJ denotes anti-CD3
T16395 24808-24809 NN denotes /
T16396 24809-24813 CD denotes CD28
T16397 24814-24828 NN denotes co-stimulation
T16398 24829-24831 IN denotes in
T16399 24832-24833 DT denotes a
T16400 24834-24838 NN denotes time
T16401 24838-24839 : denotes -
T16402 24840-24841 -LRB- denotes (
T16403 24841-24843 IN denotes at
T16404 24844-24846 CD denotes 10
T16405 24846-24847 NN denotes −
T16406 24847-24848 CD denotes 8
T16407 24849-24850 NNP denotes M
T16408 24851-24853 NNP denotes FP
T16409 24853-24854 -RRB- denotes )
T16410 24855-24858 CC denotes and
T16411 24859-24872 NN denotes concentration
T16412 24872-24873 : denotes -
T16413 24874-24875 -LRB- denotes (
T16414 24875-24877 IN denotes at
T16415 24878-24880 CD denotes 60
T16416 24881-24884 NN denotes min
T16417 24885-24890 IN denotes after
T16418 24891-24902 NN denotes stimulation
T16419 24902-24903 -RRB- denotes )
T16420 24904-24913 JJ denotes dependent
T16421 24914-24920 NN denotes manner
T16422 24920-24921 . denotes .
T16423 24922-24927 NNS denotes Cells
T16424 24928-24932 VBD denotes were
T16425 24933-24943 VBN denotes pretreated
T16426 24944-24948 IN denotes with
T16427 24949-24951 NNP denotes FP
T16428 24952-24955 IN denotes for
T16429 24956-24958 CD denotes 30
T16430 24959-24962 NN denotes min
T16431 24963-24968 RB denotes prior
T16432 24969-24971 TO denotes to
T16433 24972-24983 NN denotes stimulation
T16434 24983-24984 . denotes .
T16435 24985-24989 CD denotes MEK1
T16436 24990-24993 CC denotes and
T16437 24994-25001 VB denotes histone
T16438 25002-25004 CD denotes H1
T16439 25005-25009 VBD denotes were
T16440 25010-25014 VBN denotes used
T16441 25015-25017 TO denotes to
T16442 25018-25029 VB denotes demonstrate
T16443 25030-25035 JJ denotes equal
T16444 25036-25047 JJ denotes cytoplasmic
T16445 25048-25051 CC denotes and
T16446 25052-25059 JJ denotes nuclear
T16447 25060-25067 VBG denotes loading
T16448 25068-25080 RB denotes respectively
T16449 25080-25081 . denotes .
T16450 25082-25089 NNS denotes Results
T16451 25090-25093 VBP denotes are
T16452 25094-25103 VBN denotes presented
T16453 25104-25115 RB denotes graphically
T16454 25116-25121 IN denotes below
T16455 25122-25124 IN denotes as
T16456 25125-25129 JJ denotes mean
T16457 25129-25130 NN denotes ±
T16458 25130-25133 NNP denotes SEM
T16459 25134-25136 IN denotes of
T16460 25137-25139 IN denotes at
T16461 25140-25145 JJS denotes least
T16462 25146-25151 CD denotes three
T16463 25152-25163 JJ denotes independent
T16464 25164-25175 NNS denotes experiments
T16465 25175-25176 . denotes .
T16466 25177-25180 FW denotes ***
T16467 25181-25182 FW denotes p
T16468 25182-25183 FW denotes <
T16469 25183-25188 CD denotes 0.001
T16470 25189-25197 VBN denotes compared
T16471 25198-25200 TO denotes to
T16472 25201-25202 VB denotes t
T16473 25203-25204 SYM denotes =
T16474 25205-25206 CD denotes 0
T16475 25206-25207 . denotes .
T16476 25208-25209 -LRB- denotes (
T16477 25209-25210 NNP denotes D
T16478 25210-25211 -RRB- denotes )
T16479 25212-25218 NNP denotes RT-PCR
T16480 25219-25226 VBG denotes showing
T16481 25227-25231 IN denotes that
T16482 25232-25234 NNP denotes FP
T16483 25235-25243 VBZ denotes inhibits
T16484 25244-25248 NN denotes IL-4
T16485 25249-25252 CC denotes and
T16486 25253-25257 NN denotes IL-5
T16487 25258-25262 NNP denotes mRNA
T16488 25263-25273 NN denotes expression
T16489 25274-25276 IN denotes in
T16490 25277-25298 JJ denotes CD3/CD28-costimulated
T16491 25299-25304 NNS denotes cells
T16492 25304-25305 . denotes .
T16493 25306-25311 NNP denotes GAPDH
T16494 25312-25315 VBD denotes was
T16495 25316-25320 VBN denotes used
T16496 25321-25323 IN denotes as
T16497 25324-25325 DT denotes a
T16498 25326-25333 VBG denotes loading
T16499 25334-25341 NN denotes control
T16500 25341-25342 . denotes .
T16501 25343-25348 JJR denotes Lower
T16502 25349-25355 NNS denotes panels
T16503 25356-25360 VBP denotes show
T16504 25361-25370 JJ denotes graphical
T16505 25371-25379 NN denotes analysis
T16506 25380-25382 IN denotes of
T16507 25383-25390 NNS denotes results
T16508 25391-25400 VBN denotes presented
T16509 25401-25403 IN denotes as
T16510 25404-25408 JJ denotes mean
T16511 25408-25409 NN denotes ±
T16512 25409-25412 NNP denotes SEM
T16513 25413-25415 IN denotes of
T16514 25416-25418 IN denotes at
T16515 25419-25424 JJS denotes least
T16516 25425-25430 CD denotes three
T16517 25431-25442 JJ denotes independent
T16518 25443-25454 NNS denotes experiments
T16519 25454-25455 . denotes .
T16520 25456-25459 FW denotes ###
T16521 25181-25182 FW denotes p
T16522 25182-25183 FW denotes <
T16523 25183-25188 CD denotes 0.001
T16524 25189-25197 VBN denotes compared
T16525 25198-25200 TO denotes to
T16526 25480-25487 VB denotes control
T16527 25487-25488 , denotes ,
T16528 25489-25492 FW denotes ***
T16529 25492-25493 FW denotes p
T16530 25493-25494 FW denotes <
T16531 25494-25499 CD denotes 0.001
T16532 25500-25508 VBN denotes compared
T16533 25509-25511 TO denotes to
T16534 25512-25520 JJ denotes anti-CD3
T16535 25520-25521 NN denotes /
T16536 25521-25525 CD denotes CD28
T16537 25526-25536 VBN denotes stimulated
T16538 25536-25537 . denotes .
T16539 25538-25539 -LRB- denotes (
T16540 25539-25540 NNP denotes E
T16541 25540-25541 -RRB- denotes )
T16542 25542-25544 NNP denotes FP
T16543 25545-25546 -LRB- denotes (
T16544 25546-25548 CD denotes 10
T16545 25549-25551 NNP denotes nM
T16546 25551-25552 -RRB- denotes )
T16547 25553-25560 VBZ denotes reduces
T16548 25561-25564 DT denotes the
T16549 25565-25572 NN denotes ability
T16550 25573-25575 IN denotes of
T16551 25576-25584 JJ denotes anti-CD3
T16552 25584-25585 NN denotes /
T16553 25585-25600 JJ denotes CD28-stimulated
T16554 25601-25607 NN denotes GATA-3
T16555 25608-25610 TO denotes to
T16556 25611-25620 VB denotes associate
T16557 25621-25625 IN denotes with
T16558 25626-25629 DT denotes the
T16559 25630-25636 JJ denotes native
T16560 25637-25641 NN denotes IL-5
T16561 25642-25650 NN denotes promoter
T16562 25651-25653 CD denotes 60
T16563 25654-25657 NN denotes min
T16564 25658-25663 IN denotes after
T16565 25664-25675 NN denotes stimulation
T16566 25675-25676 . denotes .
T16567 25677-25681 NNS denotes Data
T16568 25682-25685 VBP denotes are
T16569 25686-25690 RB denotes also
T16570 25691-25696 VBN denotes shown
T16571 25697-25708 RB denotes graphically
T16572 25709-25711 IN denotes as
T16573 25712-25716 JJ denotes mean
T16574 25716-25717 NN denotes ±
T16575 25717-25720 NNP denotes SEM
T16576 25721-25723 IN denotes of
T16577 25724-25729 CD denotes three
T16578 25730-25741 JJ denotes independent
T16579 25742-25753 NNS denotes experiments
T16580 25753-25754 . denotes .
T16581 25755-25758 DT denotes All
T16582 25759-25763 NNS denotes data
T16583 25764-25768 VBD denotes were
T16584 25769-25777 VBN denotes analysed
T16585 25778-25780 IN denotes by
T16586 25781-25786 NNP denotes ANOVA
T16587 25787-25795 VBD denotes followed
T16588 25796-25798 IN denotes by
T16589 25799-25811 NNP denotes Newman-Keuls
T16590 25812-25821 JJS denotes post-test
T16591 25821-25822 . denotes .
T17105 26735-26746 NNP denotes Fluticasone
T17106 26747-26757 NN denotes propionate
T17107 26758-26765 VBZ denotes reduces
T17108 26766-26772 JJ denotes GATA-3
T17109 26773-26784 NN denotes association
T17110 26785-26789 IN denotes with
T17111 26790-26800 JJ denotes importin-α
T17112 26801-26804 CC denotes and
T17113 26805-26811 JJ denotes GATA-3
T17114 26812-26819 JJ denotes nuclear
T17115 26820-26826 NN denotes import
T17116 26826-26827 . denotes .
T17117 26828-26829 -LRB- denotes (
T17118 26829-26830 NN denotes A
T17119 26830-26831 -RRB- denotes )
T17120 26832-26839 JJ denotes Western
T17121 26840-26844 NN denotes blot
T17122 26845-26853 NN denotes analysis
T17123 26854-26866 VBZ denotes demonstrates
T17124 26867-26868 DT denotes a
T17125 26869-26873 NN denotes time
T17126 26873-26874 : denotes -
T17127 26875-26876 -LRB- denotes (
T17128 26876-26878 IN denotes at
T17129 26879-26881 CD denotes 10
T17130 26881-26882 NN denotes −
T17131 26882-26883 CD denotes 8
T17132 26884-26885 NNP denotes M
T17133 26886-26888 NNP denotes FP
T17134 26888-26889 -RRB- denotes )
T17135 26890-26893 CC denotes and
T17136 26894-26907 NN denotes concentration
T17137 26907-26908 : denotes -
T17138 26909-26910 -LRB- denotes (
T17139 26910-26912 IN denotes at
T17140 26913-26915 CD denotes 60
T17141 26916-26919 NN denotes min
T17142 26920-26925 IN denotes after
T17143 26926-26937 NN denotes stimulation
T17144 26937-26938 -RRB- denotes )
T17145 26939-26948 JJ denotes dependent
T17146 26949-26958 NN denotes induction
T17147 26959-26961 IN denotes of
T17148 26962-26974 JJ denotes FP-activated
T17149 26975-26977 NNP denotes GR
T17150 26978-26989 NN denotes interaction
T17151 26990-26994 IN denotes with
T17152 26995-27005 JJ denotes importin-α
T17153 27006-27007 -LRB- denotes (
T17154 27007-27012 JJ denotes Imp-α
T17155 27012-27013 -RRB- denotes )
T17156 27013-27014 . denotes .
T17157 27015-27016 DT denotes A
T17158 27017-27025 JJ denotes positive
T17159 27026-27033 NN denotes control
T17160 27034-27037 IN denotes for
T17161 27038-27040 NNP denotes GR
T17162 27041-27052 NN denotes association
T17163 27053-27057 IN denotes with
T17164 27058-27066 NN denotes importin
T17165 27067-27069 VBZ denotes is
T17166 27070-27075 VBN denotes shown
T17167 27075-27076 . denotes .
T17168 27077-27091 NN denotes Quantification
T17169 27092-27094 IN denotes of
T17170 27095-27098 DT denotes the
T17171 27099-27111 NN denotes densitometry
T17172 27112-27116 NN denotes data
T17173 27117-27119 VBZ denotes is
T17174 27120-27125 VBN denotes shown
T17175 27126-27131 IN denotes below
T17176 27131-27132 . denotes .
T17177 27133-27137 DT denotes Each
T17178 27138-27141 NN denotes bar
T17179 27142-27152 VBZ denotes represents
T17180 27153-27157 JJ denotes mean
T17181 27157-27158 NN denotes ±
T17182 27158-27161 NNP denotes SEM
T17183 27162-27164 IN denotes of
T17184 27165-27167 IN denotes at
T17185 27168-27173 JJS denotes least
T17186 27174-27179 CD denotes three
T17187 27180-27191 JJ denotes independent
T17188 27192-27203 NNS denotes experiments
T17189 27203-27204 . denotes .
T17190 27205-27208 FW denotes ***
T17191 27209-27210 FW denotes p
T17192 27210-27211 FW denotes <
T17193 27211-27216 CD denotes 0.001
T17194 27217-27225 VBN denotes compared
T17195 27226-27228 TO denotes to
T17196 27229-27236 VB denotes control
T17197 27236-27237 , denotes ,
T17198 27238-27241 FW denotes ###
T17199 27242-27243 FW denotes p
T17200 27243-27244 FW denotes <
T17201 27244-27249 CD denotes 0.001
T17202 27249-27250 . denotes .
T17203 27251-27252 -LRB- denotes (
T17204 27252-27253 NNP denotes B
T17205 27253-27254 -RRB- denotes )
T17206 27255-27262 NNP denotes Western
T17207 27263-27267 NN denotes blot
T17208 27268-27276 NN denotes analysis
T17209 27277-27289 VBD denotes demonstrated
T17210 27290-27291 DT denotes a
T17211 27292-27296 NN denotes time
T17212 27296-27297 : denotes -
T17213 27298-27299 -LRB- denotes (
T17214 27299-27301 IN denotes at
T17215 27302-27304 CD denotes 10
T17216 27304-27305 NN denotes −
T17217 27305-27306 CD denotes 8
T17218 27307-27308 NNP denotes M
T17219 27309-27311 NNP denotes FP
T17220 27311-27312 -RRB- denotes )
T17221 27313-27316 CC denotes and
T17222 27317-27330 NN denotes concentration
T17223 27330-27331 : denotes -
T17224 27332-27333 -LRB- denotes (
T17225 27333-27335 IN denotes at
T17226 27336-27338 CD denotes 60
T17227 27339-27342 NN denotes min
T17228 27343-27348 IN denotes after
T17229 27349-27360 NN denotes stimulation
T17230 27360-27361 -RRB- denotes )
T17231 27362-27371 JJ denotes dependent
T17232 27372-27381 NN denotes induction
T17233 27382-27384 IN denotes of
T17234 27385-27397 JJ denotes FP-activated
T17235 27398-27400 NNP denotes GR
T17236 27401-27408 JJ denotes nuclear
T17237 27409-27422 NN denotes translocation
T17238 27423-27431 VBN denotes measured
T17239 27432-27434 IN denotes by
T17240 27435-27437 NNP denotes IP
T17241 27437-27438 . denotes .
T17242 27439-27453 NN denotes Quantification
T17243 27454-27456 IN denotes of
T17244 27457-27460 DT denotes the
T17245 27461-27473 NN denotes densitometry
T17246 27474-27478 NN denotes data
T17247 27479-27481 VBZ denotes is
T17248 27482-27487 VBN denotes shown
T17249 27488-27493 IN denotes below
T17250 27493-27494 . denotes .
T17251 27495-27499 DT denotes Each
T17252 27500-27503 NN denotes bar
T17253 27504-27514 VBZ denotes represents
T17254 27515-27519 JJ denotes mean
T17255 27519-27520 NN denotes ±
T17256 27520-27523 NNP denotes SEM
T17257 27524-27526 IN denotes of
T17258 27527-27529 IN denotes at
T17259 27530-27535 JJS denotes least
T17260 27536-27541 CD denotes three
T17261 27542-27553 JJ denotes independent
T17262 27554-27565 NNS denotes experiments
T17263 27565-27566 . denotes .
T17264 27567-27570 FW denotes ***
T17265 27570-27571 FW denotes p
T17266 27571-27572 FW denotes <
T17267 27572-27577 CD denotes 0.001
T17268 27578-27586 VBN denotes compared
T17269 27587-27589 TO denotes to
T17270 27590-27597 VB denotes control
T17271 27597-27598 . denotes .
T17272 27599-27600 -LRB- denotes (
T17273 27600-27601 $ denotes C
T17274 27601-27602 -RRB- denotes )
T17275 27603-27610 JJ denotes Western
T17276 27611-27615 NN denotes blot
T17277 27616-27624 NN denotes analysis
T17278 27625-27627 IN denotes of
T17279 27628-27634 JJ denotes HuT-78
T17280 27635-27640 NNS denotes cells
T17281 27641-27648 VBN denotes treated
T17282 27649-27653 IN denotes with
T17283 27654-27656 NNP denotes FP
T17284 27657-27660 CC denotes and
T17285 27661-27669 JJ denotes anti-CD3
T17286 27669-27670 NN denotes /
T17287 27670-27674 CD denotes CD28
T17288 27675-27689 NN denotes co-stimulation
T17289 27690-27702 VBD denotes demonstrated
T17290 27703-27704 DT denotes a
T17291 27705-27728 JJ denotes concentration-dependent
T17292 27729-27737 NN denotes decrease
T17293 27738-27740 IN denotes in
T17294 27741-27747 NNP denotes GATA-3
T17295 27748-27758 JJ denotes importin-α
T17296 27759-27770 NN denotes association
T17297 27771-27773 IN denotes at
T17298 27774-27776 CD denotes 20
T17299 27777-27780 NN denotes min
T17300 27780-27781 . denotes .
T17301 27782-27796 NN denotes Quantification
T17302 27797-27799 IN denotes of
T17303 27800-27803 DT denotes the
T17304 27804-27816 NN denotes densitometry
T17305 27817-27821 NN denotes data
T17306 27822-27824 VBZ denotes is
T17307 27825-27830 VBN denotes shown
T17308 27831-27836 IN denotes below
T17309 27836-27837 . denotes .
T17310 27838-27842 DT denotes Each
T17311 27843-27846 NN denotes bar
T17312 27847-27857 VBZ denotes represents
T17313 27858-27862 JJ denotes mean
T17314 27862-27863 NN denotes ±
T17315 27863-27866 NNP denotes SEM
T17316 27867-27869 IN denotes of
T17317 27870-27872 IN denotes at
T17318 27873-27878 JJS denotes least
T17319 27879-27884 CD denotes three
T17320 27885-27896 JJ denotes independent
T17321 27897-27908 NNS denotes experiments
T17322 27908-27909 . denotes .
T17323 27910-27913 FW denotes ###
T17324 25181-25182 FW denotes p
T17325 25182-25183 FW denotes <
T17326 25183-25188 CD denotes 0.001
T17327 25189-25197 VBN denotes compared
T17328 25198-25200 TO denotes to
T17329 25480-25487 VB denotes control
T17330 25487-25488 , denotes ,
T17331 25489-25492 FW denotes ***
T17332 25492-25493 FW denotes p
T17333 25493-25494 FW denotes <
T17334 25494-25499 CD denotes 0.001
T17335 25500-25508 VBN denotes compared
T17336 25509-25511 TO denotes to
T17337 27966-27970 JJ denotes αCD3
T17338 27970-27971 NN denotes /
T17339 27971-27986 JJ denotes CD28-stimulated
T17340 27987-27992 NNS denotes cells
T17341 27992-27993 . denotes .
T17342 27994-27995 -LRB- denotes (
T17343 27995-27996 NNP denotes D
T17344 27996-27997 -RRB- denotes )
T17345 27998-28008 JJ denotes GFP-tagged
T17346 28009-28015 NN denotes GATA-3
T17347 28016-28019 VBD denotes was
T17348 28020-28033 VBN denotes overexpressed
T17349 28034-28037 CC denotes and
T17350 28038-28043 NNS denotes cells
T17351 28044-28054 VBN denotes stimulated
T17352 28055-28056 -LRB- denotes (
T17353 28056-28057 NN denotes b
T17354 28057-28058 , denotes ,
T17355 28059-28060 NN denotes c
T17356 28060-28061 -RRB- denotes )
T17357 28062-28064 CC denotes or
T17358 28065-28068 RB denotes not
T17359 28069-28070 -LRB- denotes (
T17360 28070-28071 DT denotes a
T17361 28071-28072 -RRB- denotes )
T17362 28073-28076 IN denotes for
T17363 28077-28079 CD denotes 30
T17364 28080-28083 NN denotes min
T17365 28084-28088 IN denotes with
T17366 28089-28097 JJ denotes anti-CD3
T17367 28097-28098 NN denotes /
T17368 28098-28102 NNP denotes CD28
T17369 28102-28103 . denotes .
T17370 28104-28107 DT denotes The
T17371 28108-28114 NN denotes effect
T17372 28115-28117 IN denotes of
T17373 28118-28120 CD denotes 30
T17374 28121-28124 NN denotes min
T17375 28125-28137 NN denotes pretreatment
T17376 28138-28140 IN denotes of
T17377 28141-28146 NNS denotes cells
T17378 28147-28151 IN denotes with
T17379 28152-28154 NNP denotes FP
T17380 28155-28156 -LRB- denotes (
T17381 28156-28158 CD denotes 10
T17382 28158-28159 NN denotes −
T17383 28159-28160 CD denotes 8
T17384 28161-28162 NNP denotes M
T17385 28162-28163 , denotes ,
T17386 28164-28165 NN denotes c
T17387 28165-28166 -RRB- denotes )
T17388 28167-28169 VBZ denotes is
T17389 28170-28174 RB denotes also
T17390 28175-28180 VBN denotes shown
T17391 28180-28181 . denotes .
T17392 28182-28185 DT denotes All
T17393 28186-28190 NNS denotes data
T17394 28191-28195 VBD denotes were
T17395 28196-28204 VBN denotes analysed
T17396 28205-28207 IN denotes by
T17397 28208-28213 NNP denotes ANOVA
T17398 28214-28222 VBD denotes followed
T17399 28223-28225 IN denotes by
T17400 28226-28238 NNP denotes Newman-Keuls
T17401 28239-28248 JJS denotes post-test
T17402 28248-28249 . denotes .
T17853 29403-29414 NNP denotes Fluticasone
T17854 29415-29425 NN denotes propionate
T17855 29426-29434 VBN denotes mediated
T17856 29435-29445 NN denotes inhibition
T17857 29446-29448 IN denotes of
T17858 29449-29452 CD denotes p38
T17859 29453-29456 NNP denotes MAP
T17860 29457-29463 NN denotes kinase
T17861 29464-29479 NN denotes phosphorylation
T17862 29480-29483 CC denotes and
T17863 29484-29494 NN denotes activation
T17864 29495-29497 VBZ denotes is
T17865 29498-29508 VBN denotes associated
T17866 29509-29513 IN denotes with
T17867 29514-29515 DT denotes a
T17868 29516-29522 JJ denotes marked
T17869 29523-29538 NN denotes down-regulation
T17870 29539-29541 IN denotes of
T17871 29542-29548 JJ denotes GATA-3
T17872 29549-29555 NN denotes serine
T17873 29556-29571 NN denotes phosphorylation
T17874 29571-29572 . denotes .
T17875 29573-29574 -LRB- denotes (
T17876 29574-29575 NN denotes A
T17877 29575-29576 -RRB- denotes )
T17878 29577-29584 JJ denotes Western
T17879 29585-29589 NN denotes blot
T17880 29590-29598 NN denotes analysis
T17881 29599-29604 VBZ denotes shows
T17882 29605-29609 IN denotes that
T17883 29610-29612 NNP denotes FP
T17884 29613-29614 -LRB- denotes (
T17885 29614-29616 CD denotes 10
T17886 29616-29617 NN denotes −
T17887 29617-29618 CD denotes 8
T17888 29619-29620 NNP denotes M
T17889 29620-29621 , denotes ,
T17890 29622-29624 CD denotes 30
T17891 29625-29628 NN denotes min
T17892 29628-29629 -RRB- denotes )
T17893 29630-29639 NN denotes treatment
T17894 29640-29647 VBD denotes reduced
T17895 29648-29652 JJ denotes dual
T17896 29653-29668 NN denotes phosphorylation
T17897 29669-29670 -LRB- denotes (
T17898 29670-29683 NN denotes threonine-180
T17899 29684-29687 CC denotes and
T17900 29688-29700 NN denotes tyrosine-182
T17901 29700-29701 -RRB- denotes )
T17902 29702-29704 IN denotes of
T17903 29705-29708 CD denotes p38
T17904 29709-29713 NNP denotes MAPK
T17905 29714-29716 IN denotes in
T17906 29717-29725 JJ denotes anti-CD3
T17907 29725-29726 NN denotes /
T17908 29726-29730 CD denotes CD28
T17909 29731-29744 JJ denotes co-stimulated
T17910 29745-29751 JJ denotes HuT-78
T17911 29752-29757 NNS denotes cells
T17912 29757-29758 . denotes .
T17913 29759-29760 -LRB- denotes (
T17914 29760-29761 NNP denotes B
T17915 29761-29762 -RRB- denotes )
T17916 29763-29767 NNP denotes Time
T17917 29768-29774 NN denotes course
T17918 29775-29777 IN denotes of
T17919 29778-29781 DT denotes the
T17920 29782-29788 NN denotes effect
T17921 29789-29791 IN denotes of
T17922 29792-29794 NNP denotes FP
T17923 29795-29796 -LRB- denotes (
T17924 29796-29798 CD denotes 10
T17925 29798-29799 NN denotes −
T17926 29799-29800 CD denotes 8
T17927 29801-29802 NNP denotes M
T17928 29802-29803 -RRB- denotes )
T17929 29804-29806 IN denotes on
T17930 29807-29822 NN denotes phosphorylation
T17931 29823-29825 IN denotes of
T17932 29826-29835 VBN denotes activated
T17933 29836-29849 NN denotes transcription
T17934 29850-29856 NN denotes factor
T17935 29857-29858 CD denotes 2
T17936 29859-29860 -LRB- denotes (
T17937 29860-29865 NN denotes ATF-2
T17938 29865-29866 -RRB- denotes )
T17939 29866-29867 , denotes ,
T17940 29868-29869 DT denotes a
T17941 29870-29877 NN denotes measure
T17942 29878-29880 IN denotes of
T17943 29881-29884 CD denotes p38
T17944 29885-29889 NNP denotes MAPK
T17945 29890-29898 NN denotes activity
T17946 29898-29899 . denotes .
T17947 29900-29901 -LRB- denotes (
T17948 29901-29902 $ denotes C
T17949 29902-29903 -RRB- denotes )
T17950 29904-29914 JJ denotes FP-induced
T17951 29915-29925 NN denotes inhibition
T17952 29926-29928 IN denotes of
T17953 29929-29932 CD denotes p38
T17954 29933-29937 NNP denotes MAPK
T17955 29938-29946 NN denotes activity
T17956 29947-29949 VBZ denotes is
T17957 29950-29960 VBN denotes associated
T17958 29961-29965 IN denotes with
T17959 29966-29969 DT denotes the
T17960 29970-29978 NN denotes decrease
T17961 29979-29981 IN denotes of
T17962 29982-29990 JJ denotes anti-CD3
T17963 29990-29991 NN denotes /
T17964 29991-29995 CD denotes CD28
T17965 29996-30010 NN denotes co-stimulation
T17966 30011-30018 VBD denotes induced
T17967 30019-30025 JJ denotes serine
T17968 30026-30041 NN denotes phosphorylation
T17969 30042-30043 -LRB- denotes (
T17970 30043-30048 NN denotes P-Ser
T17971 30048-30049 -RRB- denotes )
T17972 30050-30052 IN denotes of
T17973 30053-30059 NN denotes GATA-3
T17974 30059-30060 . denotes .
T17975 30061-30064 IN denotes For
T17976 30065-30066 -LRB- denotes (
T17977 30066-30067 DT denotes A
T17978 30068-30069 NNP denotes C
T17979 30069-30070 -RRB- denotes )
T17980 30070-30071 , denotes ,
T17981 30072-30086 NN denotes quantification
T17982 30087-30089 IN denotes of
T17983 30090-30093 DT denotes the
T17984 30094-30106 NN denotes densitometry
T17985 30107-30111 NN denotes data
T17986 30112-30114 VBZ denotes is
T17987 30115-30119 RB denotes also
T17988 30120-30125 VBN denotes shown
T17989 30125-30126 . denotes .
T17990 30127-30131 DT denotes Each
T17991 30132-30135 NN denotes bar
T17992 30136-30146 VBZ denotes represents
T17993 30147-30151 JJ denotes mean
T17994 30151-30152 NN denotes ±
T17995 30152-30155 NNP denotes SEM
T17996 30156-30158 IN denotes of
T17997 30159-30161 IN denotes at
T17998 30162-30167 JJS denotes least
T17999 30168-30173 CD denotes three
T18000 30174-30185 JJ denotes independent
T18001 30186-30197 NNS denotes experiments
T18002 30197-30198 . denotes .
T18003 30199-30202 FW denotes ###
T18004 25181-25182 FW denotes p
T18005 25182-25183 FW denotes <
T18006 25183-25188 CD denotes 0.001
T18007 25189-25197 VBN denotes compared
T18008 25198-25200 TO denotes to
T18009 25480-25487 VB denotes control
T18010 25487-25488 , denotes ,
T18011 25489-25492 FW denotes ***
T18012 25492-25493 FW denotes p
T18013 25493-25494 FW denotes <
T18014 25494-25499 CD denotes 0.001
T18015 25500-25508 VBN denotes compared
T18016 25509-25511 TO denotes to
T18017 27966-27970 JJ denotes αCD3
T18018 27970-27971 NN denotes /
T18019 27971-27986 JJ denotes CD28-stimulated
T18020 27987-27992 NNS denotes cells
T18021 27992-27993 . denotes .
T18022 27994-27995 -LRB- denotes (
T18023 27995-27996 NNP denotes D
T18024 27996-27997 -RRB- denotes )
T18025 30287-30289 NNP denotes FP
T18026 30290-30297 VBD denotes induced
T18027 30298-30303 NNP denotes MKP-1
T18028 30304-30308 NNP denotes mRNA
T18029 30309-30311 IN denotes in
T18030 30312-30313 DT denotes a
T18031 30314-30337 JJ denotes concentration-dependent
T18032 30338-30344 NN denotes manner
T18033 30344-30345 . denotes .
T18034 30346-30349 DT denotes All
T18035 30350-30357 NNS denotes results
T18036 30358-30361 VBP denotes are
T18037 30362-30376 NN denotes representative
T18038 30377-30379 IN denotes of
T18039 30380-30382 IN denotes at
T18040 30383-30388 JJS denotes least
T18041 30389-30394 CD denotes three
T18042 30395-30406 JJ denotes independent
T18043 30407-30418 NNS denotes experiments
T18044 30419-30422 CC denotes and
T18045 30423-30428 WRB denotes where
T18046 30429-30440 JJ denotes appropriate
T18047 30441-30450 VBN denotes expressed
T18048 30451-30453 IN denotes as
T18049 30454-30459 NNS denotes means
T18050 30459-30460 VBP denotes ±
T18051 30460-30463 NNP denotes SEM
T18052 30463-30464 , denotes ,
T18053 30465-30466 SYM denotes *
T18054 30466-30467 FW denotes p
T18055 30467-30468 FW denotes <
T18056 30468-30472 CD denotes 0.05
T18057 30472-30473 . denotes .
T18058 30474-30475 -LRB- denotes (
T18059 30475-30476 NNP denotes E
T18060 30476-30477 -RRB- denotes )
T18061 30478-30480 NNP denotes FP
T18062 30481-30488 VBZ denotes induces
T18063 30489-30494 NNP denotes MKP-1
T18064 30495-30499 NNP denotes mRNA
T18065 30500-30502 IN denotes in
T18066 30503-30504 DT denotes a
T18067 30505-30519 JJ denotes time-dependent
T18068 30520-30526 NN denotes manner
T18069 30526-30527 . denotes .
T18070 30528-30535 NNS denotes Results
T18071 30536-30539 VBP denotes are
T18072 30540-30554 NN denotes representative
T18073 30555-30557 IN denotes of
T18074 30558-30561 CD denotes two
T18075 30562-30573 JJ denotes independent
T18076 30574-30585 NNS denotes experiments
T18077 30585-30586 . denotes .
T18078 30587-30590 DT denotes All
T18079 30591-30595 NNS denotes data
T18080 30596-30602 IN denotes except
T18081 30603-30604 -LRB- denotes (
T18082 30604-30605 NNP denotes E
T18083 30605-30606 -RRB- denotes )
T18084 30607-30611 VBD denotes were
T18085 30612-30620 VBN denotes analysed
T18086 30621-30623 IN denotes by
T18087 30624-30629 NNP denotes ANOVA
T18088 30630-30638 VBD denotes followed
T18089 30639-30641 IN denotes by
T18090 30642-30654 NNP denotes Newman-Keuls
T18091 30655-30664 JJS denotes post-test
T18092 30664-30665 . denotes .
T18334 31453-31464 NNP denotes Fluticasone
T18335 31465-31475 NN denotes propionate
T18336 31476-31484 VBZ denotes competes
T18337 31485-31489 IN denotes with
T18338 31490-31504 NN denotes phospho-GATA-3
T18339 31505-31508 IN denotes for
T18340 31509-31519 NN denotes importin-α
T18341 31519-31520 . denotes .
T18342 31521-31522 -LRB- denotes (
T18343 31522-31523 NNP denotes A
T18344 31523-31524 -RRB- denotes )
T18345 31525-31534 JJ denotes schematic
T18346 31535-31549 NN denotes representation
T18347 31550-31552 IN denotes of
T18348 31553-31556 DT denotes the
T18349 31557-31559 IN denotes in
T18350 31560-31565 NN denotes vitro
T18351 31566-31573 JJ denotes binding
T18352 31574-31585 NN denotes competition
T18353 31586-31591 NN denotes assay
T18354 31591-31592 . denotes .
T18355 31593-31594 -LRB- denotes (
T18356 31594-31595 NNP denotes B
T18357 31595-31596 -RRB- denotes )
T18358 31597-31599 NNP denotes GR
T18359 31600-31608 VBD denotes isolated
T18360 31609-31613 IN denotes from
T18361 31614-31616 NNP denotes FP
T18362 31617-31618 -LRB- denotes (
T18363 31618-31620 CD denotes 10
T18364 31620-31621 NN denotes −
T18365 31621-31622 CD denotes 8
T18366 31623-31624 NNP denotes M
T18367 31624-31625 -RRB- denotes )
T18368 31626-31636 VBD denotes stimulated
T18369 31637-31642 NNS denotes cells
T18370 31643-31651 VBZ denotes enhances
T18371 31652-31654 NNP denotes GR
T18372 31655-31665 JJ denotes importin-α
T18373 31666-31673 JJ denotes binding
T18374 31674-31676 IN denotes in
T18375 31677-31680 DT denotes the
T18376 31681-31689 NN denotes presence
T18377 31690-31691 -LRB- denotes (
T18378 31691-31692 FW denotes •
T18379 31692-31693 -RRB- denotes )
T18380 31694-31697 CC denotes and
T18381 31698-31705 NN denotes absence
T18382 31706-31707 -LRB- denotes (
T18383 31707-31708 FW denotes ▪
T18384 31708-31709 -RRB- denotes )
T18385 31710-31712 IN denotes of
T18386 31713-31722 VBN denotes activated
T18387 31723-31729 NNP denotes GATA-3
T18388 31729-31730 . denotes .
T18389 31731-31732 SYM denotes *
T18390 31733-31734 NN denotes p
T18391 31734-31735 NN denotes <
T18392 31735-31739 CD denotes 0.05
T18393 31740-31748 VBN denotes compared
T18394 31749-31751 TO denotes to
T18395 31752-31754 DT denotes no
T18396 31755-31764 VBN denotes activated
T18397 31765-31767 NNP denotes GR
T18398 31767-31768 . denotes .
T18399 31769-31770 -LRB- denotes (
T18400 31770-31771 $ denotes C
T18401 31771-31772 -RRB- denotes )
T18402 31773-31779 JJ denotes GATA-3
T18403 31780-31788 VBN denotes isolated
T18404 31789-31793 IN denotes from
T18405 31794-31802 JJ denotes anti-CD3
T18406 31802-31803 NN denotes /
T18407 31803-31807 CD denotes CD28
T18408 31808-31818 VBD denotes stimulated
T18409 31819-31824 NNS denotes cells
T18410 31825-31829 VBZ denotes does
T18411 31830-31833 RB denotes not
T18412 31834-31843 VB denotes attenuate
T18413 31844-31846 NNP denotes GR
T18414 31847-31857 JJ denotes importin-α
T18415 31858-31869 NN denotes association
T18416 31869-31870 . denotes .
T18417 31871-31872 SYM denotes *
T18418 31872-31873 NN denotes p
T18419 31873-31874 NN denotes <
T18420 31874-31878 CD denotes 0.05
T18421 31879-31887 VBN denotes compared
T18422 31888-31890 TO denotes to
T18423 31891-31898 VB denotes control
T18424 31898-31899 . denotes .
T18425 31900-31901 -LRB- denotes (
T18426 31901-31902 NNP denotes D
T18427 31902-31903 -RRB- denotes )
T18428 31904-31913 NNP denotes Activated
T18429 31914-31916 NNP denotes GR
T18430 31917-31923 VBZ denotes blocks
T18431 31924-31927 DT denotes the
T18432 31928-31935 NN denotes ability
T18433 31936-31938 IN denotes of
T18434 31939-31947 JJ denotes purified
T18435 31948-31962 JJ denotes phospho-GATA-3
T18436 31963-31971 VBN denotes isolated
T18437 31972-31976 IN denotes from
T18438 31977-31985 JJ denotes anti-CD3
T18439 31985-31986 NN denotes /
T18440 31986-31990 CD denotes CD28
T18441 31991-32001 VBD denotes stimulated
T18442 32002-32007 NNS denotes cells
T18443 32008-32019 VBG denotes interacting
T18444 32020-32024 IN denotes with
T18445 32025-32036 JJ denotes immobilised
T18446 32037-32047 NN denotes importin-α
T18447 32048-32050 IN denotes in
T18448 32051-32053 DT denotes an
T18449 32054-32056 IN denotes in
T18450 32057-32062 NN denotes vitro
T18451 32063-32070 JJ denotes binding
T18452 32071-32076 NN denotes assay
T18453 32076-32077 . denotes .
T18454 32078-32079 SYM denotes *
T18455 32079-32080 NN denotes p
T18456 32080-32081 NN denotes <
T18457 32081-32085 CD denotes 0.05
T18458 32086-32094 VBN denotes compared
T18459 32095-32097 TO denotes to
T18460 32098-32104 JJ denotes GATA-3
T18461 32105-32113 VBN denotes isolated
T18462 32114-32118 IN denotes from
T18463 32119-32131 JJ denotes unstimulated
T18464 32132-32137 NNS denotes cells
T18465 32137-32138 . denotes .
T18466 32139-32142 JJ denotes # p
T18467 32142-32143 NN denotes <
T18468 32143-32147 CD denotes 0.05
T18469 32148-32156 VBN denotes compared
T18470 32157-32159 TO denotes to
T18471 32160-32170 VBN denotes stimulated
T18472 32171-32186 JJ denotes GATA-3-importin
T18473 32187-32194 JJ denotes binding
T18474 32194-32195 . denotes .
T18475 32196-32197 -LRB- denotes (
T18476 32197-32198 NNP denotes E
T18477 32198-32199 -RRB- denotes )
T18478 32200-32203 DT denotes The
T18479 32204-32210 NN denotes effect
T18480 32211-32213 IN denotes of
T18481 32214-32223 VBN denotes activated
T18482 32224-32225 -LRB- denotes (
T18483 32225-32226 NN denotes •
T18484 32226-32227 -RRB- denotes )
T18485 32228-32234 CC denotes versus
T18486 32235-32247 JJ denotes unstimulated
T18487 32248-32249 -LRB- denotes (
T18488 32249-32250 NN denotes ○
T18489 32250-32251 -RRB- denotes )
T18490 32252-32254 NN denotes GR
T18491 32255-32257 IN denotes on
T18492 32258-32269 NN denotes attenuation
T18493 32270-32272 IN denotes of
T18494 32273-32279 NNP denotes GATA-3
T18495 32280-32290 JJ denotes importin-α
T18496 32291-32302 NN denotes association
T18497 32303-32306 VBD denotes was
T18498 32307-32330 JJ denotes concentration-dependent
T18499 32330-32331 . denotes .
T18500 32332-32333 SYM denotes *
T18501 32333-32334 NN denotes p
T18502 32334-32335 NN denotes <
T18503 32335-32339 CD denotes 0.05
T18504 32339-32340 , denotes ,
T18505 32341-32343 SYM denotes **
T18506 32343-32344 FW denotes p
T18507 32344-32345 FW denotes <
T18508 32345-32349 CD denotes 0.01
T18509 32350-32357 IN denotes between
T18510 32358-32364 NNS denotes groups
T18511 32364-32365 . denotes .
T18512 32366-32369 DT denotes All
T18513 32370-32377 NNS denotes results
T18514 32378-32381 VBP denotes are
T18515 32382-32391 VBN denotes expressed
T18516 32392-32394 IN denotes as
T18517 32395-32399 JJ denotes mean
T18518 32399-32400 NN denotes ±
T18519 32400-32403 NNP denotes SEM
T18520 32404-32406 IN denotes of
T18521 32407-32412 CD denotes three
T18522 32413-32424 JJ denotes independent
T18523 32425-32436 NNS denotes experiments
T18524 32437-32440 CC denotes and
T18525 32441-32449 VBN denotes analysed
T18526 32450-32452 IN denotes by
T18527 32453-32458 NNP denotes ANOVA
T18528 32459-32467 VBD denotes followed
T18529 32468-32470 IN denotes by
T18530 32471-32483 NNP denotes Newman-Keuls
T18531 32484-32493 JJS denotes post-test
T18532 32493-32494 . denotes .
T18930 33262-33273 NNP denotes Fluticasone
T18931 33274-33284 NN denotes propionate
T18932 33285-33289 VBZ denotes does
T18933 33290-33293 RB denotes not
T18934 33294-33300 VB denotes affect
T18935 33301-33307 JJ denotes GATA-3
T18936 33308-33315 JJ denotes nuclear
T18937 33316-33322 NN denotes export
T18938 33322-33323 . denotes .
T18939 33324-33325 -LRB- denotes (
T18940 33325-33326 NN denotes A
T18941 33326-33327 -RRB- denotes )
T18942 33328-33335 JJ denotes Western
T18943 33336-33340 NN denotes blot
T18944 33341-33349 NN denotes analysis
T18945 33350-33357 VBG denotes showing
T18946 33358-33362 IN denotes that
T18947 33363-33366 DT denotes the
T18948 33367-33374 JJ denotes nuclear
T18949 33375-33381 NN denotes export
T18950 33382-33391 NN denotes inhibitor
T18951 33392-33402 NN denotes leptomycin
T18952 33403-33404 NNP denotes B
T18953 33405-33406 -LRB- denotes (
T18954 33406-33407 CD denotes 2
T18955 33408-33410 NNP denotes nM
T18956 33410-33411 -RRB- denotes )
T18957 33412-33416 VBZ denotes does
T18958 33417-33420 RB denotes not
T18959 33421-33427 VB denotes affect
T18960 33428-33431 DT denotes the
T18961 33432-33439 NN denotes ability
T18962 33440-33442 IN denotes of
T18963 33443-33445 NNP denotes FP
T18964 33446-33447 -LRB- denotes (
T18965 33447-33449 CD denotes 10
T18966 33449-33450 NN denotes −
T18967 33450-33451 CD denotes 8
T18968 33452-33453 NNP denotes M
T18969 33453-33454 -RRB- denotes )
T18970 33455-33457 TO denotes to
T18971 33458-33465 VB denotes prevent
T18972 33466-33474 JJ denotes anti-CD3
T18973 33474-33475 NN denotes /
T18974 33475-33479 CD denotes CD28
T18975 33480-33490 VBD denotes stimulated
T18976 33491-33497 JJ denotes GATA-3
T18977 33498-33505 JJ denotes nuclear
T18978 33506-33518 NN denotes localization
T18979 33519-33527 VBN denotes measured
T18980 33528-33530 IN denotes at
T18981 33531-33533 CD denotes 60
T18982 33534-33537 NN denotes min
T18983 33537-33538 . denotes .
T18984 33539-33542 FW denotes ***
T18985 33542-33543 FW denotes p
T18986 33543-33544 FW denotes <
T18987 33544-33549 CD denotes 0.001
T18988 33550-33558 VBN denotes compared
T18989 33559-33561 TO denotes to
T18990 33562-33574 JJ denotes unstimulated
T18991 33575-33580 NNS denotes cells
T18992 33580-33581 , denotes ,
T18993 33582-33585 FW denotes ###
T18994 25492-25493 FW denotes p
T18995 25493-25494 FW denotes <
T18996 25494-25499 CD denotes 0.001
T18997 25500-25508 VBN denotes compared
T18998 25509-25511 TO denotes to
T18999 25512-25520 JJ denotes anti-CD3
T19000 25520-25521 NN denotes /
T19001 25521-25525 CD denotes CD28
T19002 25526-25536 VBD denotes stimulated
T19003 33631-33636 NNS denotes cells
T19004 33636-33637 . denotes .
T19005 33638-33639 -LRB- denotes (
T19006 33639-33640 NNP denotes B
T19007 33640-33641 -RRB- denotes )
T19008 33642-33649 NNP denotes Western
T19009 33650-33654 NN denotes blot
T19010 33655-33663 NN denotes analysis
T19011 33664-33671 VBG denotes showing
T19012 33672-33676 IN denotes that
T19013 33677-33679 NNP denotes FP
T19014 33680-33681 -LRB- denotes (
T19015 33681-33683 CD denotes 10
T19016 33683-33684 NN denotes −
T19017 33684-33685 CD denotes 8
T19018 33686-33687 NNP denotes M
T19019 33687-33688 -RRB- denotes )
T19020 33689-33693 VBZ denotes does
T19021 33694-33697 RB denotes not
T19022 33698-33704 VB denotes affect
T19023 33705-33715 JJ denotes whole-cell
T19024 33716-33722 JJ denotes GATA-3
T19025 33723-33734 NN denotes degradation
T19026 33735-33739 IN denotes over
T19027 33740-33742 CD denotes 17
T19028 33743-33745 NN denotes h.
T19029 33746-33747 -LRB- denotes (
T19030 33747-33748 NNP denotes C
T19031 33748-33749 -RRB- denotes )
T19032 33750-33760 JJ denotes GFP-tagged
T19033 33761-33767 NN denotes GATA-3
T19034 33768-33770 VBZ denotes is
T19035 33771-33784 VBN denotes overexpressed
T19036 33785-33788 CC denotes and
T19037 33789-33794 NNS denotes cells
T19038 33795-33805 VBN denotes stimulated
T19039 33806-33807 -LRB- denotes (
T19040 33807-33808 NN denotes b
T19041 33809-33810 NN denotes j
T19042 33810-33811 -RRB- denotes )
T19043 33812-33814 CC denotes or
T19044 33815-33818 RB denotes not
T19045 33819-33820 -LRB- denotes (
T19046 33820-33821 DT denotes a
T19047 33821-33822 -RRB- denotes )
T19048 33823-33827 IN denotes with
T19049 33828-33836 JJ denotes anti-CD3
T19050 33836-33837 NN denotes /
T19051 33837-33841 NNP denotes CD28
T19052 33841-33842 . denotes .
T19053 33843-33846 DT denotes The
T19054 33847-33853 NN denotes effect
T19055 33854-33856 IN denotes of
T19056 33857-33865 VBG denotes treating
T19057 33866-33871 NNS denotes cells
T19058 33872-33876 IN denotes with
T19059 33877-33879 NNP denotes FP
T19060 33880-33881 -LRB- denotes (
T19061 33881-33883 CD denotes 10
T19062 33883-33884 NN denotes −
T19063 33884-33885 CD denotes 8
T19064 33886-33887 NNP denotes M
T19065 33887-33888 , denotes ,
T19066 33889-33890 SYM denotes f
T19067 33891-33892 NN denotes j
T19068 33892-33893 -RRB- denotes )
T19069 33894-33899 IN denotes after
T19070 33900-33902 CD denotes 30
T19071 33903-33906 NN denotes min
T19072 33907-33918 NN denotes stimulation
T19073 33919-33923 IN denotes with
T19074 33924-33932 JJ denotes anti-CD3
T19075 33932-33933 NN denotes /
T19076 33933-33937 NNP denotes CD28
T19077 33938-33940 VBZ denotes is
T19078 33941-33945 RB denotes also
T19079 33946-33951 VBN denotes shown
T19080 33951-33952 . denotes .
T19081 33953-33954 -LRB- denotes (
T19082 33954-33955 NNP denotes D
T19083 33955-33956 -RRB- denotes )
T19084 33957-33959 NNP denotes FP
T19085 33960-33961 -LRB- denotes (
T19086 33961-33963 CD denotes 10
T19087 33963-33964 NN denotes −
T19088 33964-33965 CD denotes 8
T19089 33966-33967 NNP denotes M
T19090 33967-33968 -RRB- denotes )
T19091 33969-33973 VBZ denotes does
T19092 33974-33977 RB denotes not
T19093 33978-33985 VB denotes prevent
T19094 33986-33994 JJ denotes anti-CD3
T19095 33994-33995 NN denotes /
T19096 33995-33999 CD denotes CD28
T19097 34000-34010 VBD denotes stimulated
T19098 34011-34014 CD denotes p65
T19099 34015-34022 JJ denotes nuclear
T19100 34023-34036 NN denotes translocation
T19101 34037-34039 IN denotes at
T19102 34040-34042 CD denotes 60
T19103 34043-34046 NN denotes min
T19104 34047-34052 IN denotes after
T19105 34053-34064 NN denotes stimulation
T19106 34064-34065 . denotes .
T19107 34066-34068 SYM denotes **
T19108 34068-34069 FW denotes p
T19109 34069-34070 FW denotes <
T19110 34070-34074 CD denotes 0.01
T19111 34075-34083 VBN denotes compared
T19112 34084-34086 TO denotes to
T19113 34087-34099 JJ denotes unstimulated
T19114 34100-34105 NNS denotes cells
T19115 34105-34106 . denotes .
T19116 34107-34110 DT denotes All
T19117 34111-34118 NNS denotes results
T19118 34119-34122 VBP denotes are
T19119 34123-34137 NN denotes representative
T19120 34138-34140 IN denotes of
T19121 34141-34143 IN denotes at
T19122 34144-34149 JJS denotes least
T19123 34150-34154 CD denotes four
T19124 34155-34166 JJ denotes independent
T19125 34167-34178 NNS denotes experiments
T19126 34179-34182 CC denotes and
T19127 34183-34186 VBP denotes are
T19128 34187-34192 VBN denotes shown
T19129 34193-34195 IN denotes as
T19130 34196-34200 JJ denotes mean
T19131 34200-34201 NN denotes ±
T19132 34201-34204 NNP denotes SEM
T19133 34204-34205 . denotes .
T19134 34206-34213 NNS denotes Results
T19135 34214-34218 VBD denotes were
T19136 34219-34227 VBN denotes analysed
T19137 34228-34230 IN denotes by
T19138 34231-34236 NNP denotes ANOVA
T19139 34237-34245 VBD denotes followed
T19140 34246-34248 IN denotes by
T19141 34249-34261 NNP denotes Newman-Keuls
T19142 34262-34266 NN denotes test
T19143 34266-34267 . denotes .
T19430 34789-34800 NNP denotes Fluticasone
T19431 34801-34811 NN denotes propionate
T19432 34812-34819 VBZ denotes impairs
T19433 34820-34826 JJ denotes GATA-3
T19434 34827-34838 NN denotes interaction
T19435 34839-34843 IN denotes with
T19436 34844-34854 JJ denotes importin-α
T19437 34855-34858 CC denotes and
T19438 34859-34865 JJ denotes GATA-3
T19439 34866-34873 JJ denotes nuclear
T19440 34874-34886 NN denotes localization
T19441 34887-34889 IN denotes in
T19442 34890-34894 NN denotes vivo
T19443 34895-34898 CC denotes and
T19444 34899-34901 FW denotes ex
T19445 34902-34906 FW denotes vivo
T19446 34906-34907 . denotes .
T19447 34908-34909 -LRB- denotes (
T19448 34909-34910 DT denotes A
T19449 34911-34914 CC denotes and
T19450 34915-34916 NNP denotes B
T19451 34916-34917 -RRB- denotes )
T19452 34918-34940 NN denotes Co-immunoprecipitation
T19453 34941-34949 NN denotes analysis
T19454 34950-34952 IN denotes of
T19455 34953-34958 NNS denotes PBMCs
T19456 34959-34963 IN denotes from
T19457 34964-34977 JJ denotes steroid-naïve
T19458 34978-34984 NN denotes asthma
T19459 34985-34993 NNS denotes patients
T19460 34994-35001 VBN denotes treated
T19461 35002-35006 IN denotes with
T19462 35007-35009 NNP denotes FP
T19463 35010-35012 IN denotes in
T19464 35013-35018 NN denotes vitro
T19465 35019-35031 VBD denotes demonstrated
T19466 35032-35040 VBN denotes impaired
T19467 35041-35052 NN denotes interaction
T19468 35053-35060 IN denotes between
T19469 35061-35067 NNP denotes GATA-3
T19470 35068-35071 CC denotes and
T19471 35072-35082 JJ denotes importin-α
T19472 35083-35091 VBN denotes measured
T19473 35092-35094 IN denotes at
T19474 35095-35097 CD denotes 60
T19475 35098-35101 NN denotes min
T19476 35101-35102 . denotes .
T19477 35103-35107 DT denotes Each
T19478 35108-35111 NN denotes bar
T19479 35112-35122 VBZ denotes represents
T19480 35123-35126 DT denotes the
T19481 35127-35131 JJ denotes mean
T19482 35131-35132 NN denotes ±
T19483 35132-35135 NNP denotes SEM
T19484 35136-35138 IN denotes of
T19485 35139-35141 IN denotes at
T19486 35142-35147 JJS denotes least
T19487 35148-35153 CD denotes three
T19488 35154-35165 JJ denotes independent
T19489 35166-35177 NNS denotes experiments
T19490 35177-35178 : denotes ;
T19491 35179-35182 FW denotes ***
T19492 35183-35184 FW denotes p
T19493 35184-35185 FW denotes <
T19494 35185-35190 CD denotes 0.001
T19495 35191-35199 VBN denotes compared
T19496 35200-35204 IN denotes with
T19497 35205-35212 NN denotes control
T19498 35213-35215 IN denotes as
T19499 35216-35226 VBN denotes determined
T19500 35227-35229 IN denotes by
T19501 35230-35248 NNP denotes ANOVA/Newman-Keuls
T19502 35249-35257 NN denotes analysis
T19503 35257-35258 . denotes .
T19504 35259-35260 -LRB- denotes (
T19505 35260-35261 NNP denotes C
T19506 35262-35265 CC denotes and
T19507 35266-35267 NNP denotes D
T19508 35267-35268 -RRB- denotes )
T19509 35269-35291 NN denotes Co-immunoprecipitation
T19510 35292-35300 NNS denotes analyses
T19511 35301-35303 IN denotes of
T19512 35304-35309 NNS denotes PBMCs
T19513 35310-35314 IN denotes from
T19514 35315-35328 JJ denotes steroid-naïve
T19515 35329-35335 NN denotes asthma
T19516 35336-35344 NNS denotes patients
T19517 35345-35352 VBN denotes treated
T19518 35353-35357 IN denotes with
T19519 35358-35365 JJ denotes inhaled
T19520 35366-35368 NNP denotes FP
T19521 35369-35370 -LRB- denotes (
T19522 35370-35373 CD denotes 500
T19523 35374-35376 NN denotes µg
T19524 35377-35380 IN denotes via
T19525 35381-35382 DT denotes a
T19526 35383-35389 NN denotes spacer
T19527 35389-35390 -RRB- denotes )
T19528 35391-35393 IN denotes in
T19529 35394-35398 NN denotes vivo
T19530 35399-35411 VBD denotes demonstrated
T19531 35412-35421 VBN denotes decreased
T19532 35422-35433 NN denotes association
T19533 35434-35441 IN denotes between
T19534 35442-35448 NNP denotes GATA-3
T19535 35449-35452 CC denotes and
T19536 35453-35463 JJ denotes importin-α
T19537 35463-35464 . denotes .
T19538 35465-35468 DT denotes The
T19539 35469-35479 JJ denotes individual
T19540 35480-35486 NNS denotes values
T19541 35487-35490 IN denotes for
T19542 35491-35495 DT denotes each
T19543 35496-35505 NN denotes treatment
T19544 35506-35509 VBP denotes are
T19545 35510-35519 VBN denotes presented
T19546 35520-35531 RB denotes graphically
T19547 35531-35532 . denotes .
T19548 35533-35534 -LRB- denotes (
T19549 35534-35535 NNP denotes E
T19550 35535-35536 -RRB- denotes )
T19551 35537-35551 NNP denotes Representative
T19552 35552-35559 NNP denotes Western
T19553 35560-35564 NN denotes blot
T19554 35565-35572 VBG denotes showing
T19555 35573-35577 IN denotes that
T19556 35578-35588 JJ denotes importin-α
T19557 35589-35599 NN denotes expression
T19558 35600-35603 VBD denotes was
T19559 35604-35614 JJ denotes unaffected
T19560 35615-35617 IN denotes by
T19561 35618-35628 NN denotes inhalation
T19562 35629-35631 IN denotes of
T19563 35632-35634 NNP denotes FP
T19564 35634-35635 . denotes .
T19565 35636-35640 NNP denotes Blot
T19566 35641-35643 VBZ denotes is
T19567 35644-35658 NN denotes representative
T19568 35659-35661 IN denotes of
T19569 35662-35666 NNS denotes gels
T19570 35667-35671 IN denotes from
T19571 35672-35677 CD denotes three
T19572 35678-35690 NNS denotes participants
T19573 35690-35691 . denotes .
T19983 37976-37983 VBN denotes Inhaled
T19984 37984-37995 NN denotes fluticasone
T19985 37996-38006 NN denotes propionate
T19986 38007-38014 VBZ denotes impairs
T19987 38015-38021 JJ denotes GATA-3
T19988 38022-38029 JJ denotes nuclear
T19989 38030-38042 NN denotes localization
T19990 38043-38045 IN denotes in
T19991 38046-38051 NNP denotes PBMCs
T19992 38051-38052 . denotes .
T19993 38053-38054 -LRB- denotes (
T19994 38054-38055 NNP denotes A
T19995 38055-38056 -RRB- denotes )
T19996 38057-38071 NNP denotes Representative
T19997 38072-38091 NN denotes immunocytochemistry
T19998 38092-38094 IN denotes of
T19999 38095-38102 VBG denotes showing
T20000 38103-38106 DT denotes the
T20001 38107-38113 NN denotes effect
T20002 38114-38116 IN denotes of
T20003 38117-38124 JJ denotes inhaled
T20004 38125-38127 NNP denotes FP
T20005 38128-38129 -LRB- denotes (
T20006 38129-38132 CD denotes 500
T20007 38133-38135 NN denotes µg
T20008 38135-38136 -RRB- denotes )
T20009 38137-38139 IN denotes on
T20010 38140-38142 NNP denotes GR
T20011 38143-38146 CC denotes and
T20012 38147-38153 NNP denotes GATA-3
T20013 38154-38161 JJ denotes nuclear
T20014 38162-38174 NN denotes localisation
T20015 38174-38175 . denotes .
T20016 38176-38177 -LRB- denotes (
T20017 38177-38178 NNP denotes B
T20018 38178-38179 -RRB- denotes )
T20019 38180-38187 NNP denotes Nuclear
T20020 38188-38194 NNP denotes GATA-3
T20021 38195-38211 NN denotes immunoreactivity
T20022 38212-38214 IN denotes in
T20023 38215-38220 NNS denotes PBMCs
T20024 38221-38225 IN denotes from
T20025 38226-38231 CD denotes seven
T20026 38232-38245 JJ denotes steroid-naïve
T20027 38246-38252 NN denotes asthma
T20028 38253-38261 NNS denotes patients
T20029 38262-38263 CD denotes 2
T20030 38264-38265 NN denotes h
T20031 38266-38275 VBG denotes following
T20032 38276-38283 JJ denotes inhaled
T20033 38284-38286 NNP denotes FP
T20034 38287-38296 NN denotes treatment
T20035 38297-38298 -LRB- denotes (
T20036 38298-38301 CD denotes 100
T20037 38302-38304 CC denotes or
T20038 38305-38308 CD denotes 500
T20039 38309-38311 NN denotes µg
T20040 38312-38315 IN denotes via
T20041 38316-38322 NN denotes spacer
T20042 38322-38323 -RRB- denotes )
T20043 38323-38324 . denotes .
T20044 38325-38328 DT denotes The
T20045 38329-38335 NN denotes median
T20046 38336-38339 CC denotes and
T20047 38340-38353 JJ denotes interquartile
T20048 38354-38360 NNS denotes ranges
T20049 38361-38364 IN denotes for
T20050 38365-38369 DT denotes each
T20051 38370-38379 NN denotes treatment
T20052 38380-38383 VBP denotes are
T20053 38384-38393 VBN denotes presented
T20054 38394-38396 IN denotes as
T20055 38397-38398 DT denotes a
T20056 38399-38415 NNS denotes box-and-whiskers
T20057 38416-38420 NN denotes plot
T20058 38421-38422 -LRB- denotes (
T20059 38422-38423 FW denotes n
T20060 38424-38425 SYM denotes =
T20061 38426-38427 CD denotes 7
T20062 38427-38428 -RRB- denotes )
T20063 38428-38429 : denotes ;
T20064 38430-38431 SYM denotes *
T20065 38432-38433 NN denotes p
T20066 38433-38434 NN denotes <
T20067 38434-38438 CD denotes 0.05
T20068 38439-38447 NNP denotes Wilcoxon
T20069 38447-38449 POS denotes 's
T20070 38450-38454 NN denotes rank
T20071 38455-38459 NN denotes test
T20072 38460-38468 VBN denotes compared
T20073 38469-38473 IN denotes with
T20074 38474-38481 NN denotes placebo
T20075 38481-38482 . denotes .
T20076 38483-38484 -LRB- denotes (
T20077 38484-38485 NNP denotes C
T20078 38485-38486 -RRB- denotes )
T20079 38487-38501 NNP denotes Immunoblotting
T20080 38502-38510 NNS denotes analyses
T20081 38511-38513 IN denotes of
T20082 38514-38519 NNP denotes PBMCs
T20083 38520-38532 VBD denotes demonstrated
T20084 38533-38534 DT denotes a
T20085 38535-38549 JJ denotes time-dependent
T20086 38550-38558 NN denotes decrease
T20087 38559-38561 IN denotes in
T20088 38562-38569 JJ denotes nuclear
T20089 38570-38580 NN denotes expression
T20090 38581-38583 IN denotes of
T20091 38584-38590 NNP denotes GATA-3
T20092 38590-38591 , denotes ,
T20093 38592-38595 CC denotes and
T20094 38596-38605 VBD denotes increased
T20095 38606-38617 JJ denotes cytoplasmic
T20096 38618-38624 JJ denotes GATA-3
T20097 38625-38635 NN denotes expression
T20098 38636-38641 IN denotes after
T20099 38642-38652 NN denotes inhalation
T20100 38653-38655 IN denotes of
T20101 38656-38658 NNP denotes FP
T20102 38658-38659 . denotes .
T20103 38660-38661 -LRB- denotes (
T20104 38661-38662 NNP denotes D
T20105 38662-38663 -RRB- denotes )
T20106 38664-38678 NNP denotes Immunoblotting
T20107 38679-38687 NNS denotes analyses
T20108 38688-38690 IN denotes of
T20109 38691-38696 NNP denotes PBMCs
T20110 38697-38709 VBD denotes demonstrated
T20111 38710-38711 DT denotes a
T20112 38712-38726 JJ denotes dose-dependent
T20113 38727-38735 NN denotes decrease
T20114 38736-38738 IN denotes in
T20115 38739-38746 JJ denotes nuclear
T20116 38747-38757 NN denotes expression
T20117 38758-38760 IN denotes of
T20118 38761-38767 NNP denotes GATA-3
T20119 38767-38768 , denotes ,
T20120 38769-38772 CC denotes and
T20121 38773-38782 VBD denotes increased
T20122 38783-38794 JJ denotes cytoplasmic
T20123 38795-38801 JJ denotes GATA-3
T20124 38802-38812 NN denotes expression
T20125 38813-38814 CD denotes 2
T20126 38815-38816 NN denotes h
T20127 38817-38822 IN denotes after
T20128 38823-38833 NN denotes inhalation
T20129 38834-38836 IN denotes of
T20130 38837-38839 NNP denotes FP
T20131 38839-38840 . denotes .
T20132 38841-38848 NNP denotes Histone
T20133 38849-38851 NNP denotes H1
T20134 38852-38855 CC denotes and
T20135 38856-38861 NNP denotes MEK-1
T20136 38862-38876 VBG denotes immunoblotting
T20137 38877-38886 VBN denotes confirmed
T20138 38887-38897 JJ denotes equivalent
T20139 38898-38903 JJ denotes total
T20140 38904-38911 NN denotes protein
T20141 38912-38919 VBG denotes loading
T20142 38920-38923 IN denotes for
T20143 38924-38927 DT denotes the
T20144 38928-38935 JJ denotes nuclear
T20145 38936-38939 CC denotes and
T20146 38940-38951 JJ denotes cytoplasmic
T20147 38952-38961 NNS denotes fractions
T20148 38962-38974 RB denotes respectively
T20149 38974-38975 . denotes .
T20150 38976-38990 NN denotes Quantification
T20151 38991-38993 IN denotes of
T20152 38994-38997 DT denotes the
T20153 38998-39010 NN denotes densitometry
T20154 39011-39015 NNS denotes data
T20155 39016-39018 IN denotes in
T20156 39019-39020 -LRB- denotes (
T20157 39020-39021 NNP denotes C
T20158 39021-39022 -RRB- denotes )
T20159 39023-39026 CC denotes and
T20160 39027-39028 -LRB- denotes (
T20161 39028-39029 NNP denotes D
T20162 39029-39030 -RRB- denotes )
T20163 39031-39033 VBZ denotes is
T20164 39034-39039 VBN denotes shown
T20165 39040-39042 IN denotes as
T20166 39043-39044 DT denotes a
T20167 39045-39061 NNS denotes box-and-whiskers
T20168 39062-39066 NN denotes plot
T20169 39067-39069 IN denotes of
T20170 39070-39077 NNS denotes results
T20171 39078-39082 IN denotes from
T20172 39083-39084 JJ denotes n
T20173 39085-39086 SYM denotes =
T20174 39087-39088 CD denotes 6
T20175 39089-39101 NNS denotes participants
T20176 39102-39105 IN denotes for
T20177 39106-39111 WDT denotes which
T20178 39112-39116 NNS denotes data
T20179 39117-39121 VBD denotes were
T20180 39122-39131 JJ denotes available
T20181 39131-39132 . denotes .
T20182 39133-39134 SYM denotes *
T20183 39134-39135 NN denotes p
T20184 39135-39136 NN denotes <
T20185 39136-39140 CD denotes 0.05
T20186 39141-39149 VBN denotes compared
T20187 39150-39152 TO denotes to
T20188 39153-39160 VB denotes control
T20189 39160-39161 . denotes .
T20190 39162-39163 -LRB- denotes (
T20191 39163-39164 NNP denotes E
T20192 39164-39165 -RRB- denotes )
T20193 39166-39173 NNP denotes Western
T20194 39174-39178 NN denotes blot
T20195 39179-39187 NNS denotes analyses
T20196 39188-39190 IN denotes of
T20197 39191-39196 NNP denotes PBMCs
T20198 39197-39209 VBD denotes demonstrated
T20199 39210-39211 DT denotes a
T20200 39212-39226 JJ denotes time-dependent
T20201 39227-39235 NN denotes decrease
T20202 39236-39238 IN denotes in
T20203 39239-39243 JJ denotes dual
T20204 39244-39259 NN denotes phosphorylation
T20205 39260-39261 -LRB- denotes (
T20206 39261-39274 NN denotes threonine-180
T20207 39275-39278 CC denotes and
T20208 39279-39291 NN denotes tyrosine-182
T20209 39291-39292 -RRB- denotes )
T20210 39293-39295 IN denotes of
T20211 39296-39299 CD denotes p38
T20212 39300-39304 NNP denotes MAPK
T20213 39305-39310 IN denotes after
T20214 39311-39321 NN denotes inhalation
T20215 39322-39324 IN denotes of
T20216 39325-39327 NNP denotes FP
T454 0-11 NN denotes Suppression
T455 12-14 IN denotes of
T456 15-21 NNP denotes GATA-3
T457 22-29 NNP denotes Nuclear
T458 30-36 NN denotes Import
T459 37-40 CC denotes and
T460 41-56 NNP denotes Phosphorylation
T461 56-57 : denotes :
T462 58-59 NNP denotes A
T463 60-65 NNP denotes Novel
T464 66-75 NNP denotes Mechanism
T465 76-78 IN denotes of
T466 79-93 NNP denotes Corticosteroid
T467 94-100 NNP denotes Action
T468 101-103 IN denotes in
T469 104-112 NNP denotes Allergic
T470 113-120 NNP denotes Disease
T471 455-465 NNP denotes Background
T472 466-472 NNP denotes GATA-3
T473 473-478 VBZ denotes plays
T474 479-480 DT denotes a
T475 481-489 JJ denotes critical
T476 490-494 NN denotes role
T20217 39328-39329 -LRB- denotes (
T20218 39329-39332 CD denotes 500
T20219 39333-39335 NN denotes µg
T20220 39335-39336 -RRB- denotes )
T20221 39336-39337 . denotes .
T20222 39338-39341 DT denotes The
T20223 39342-39349 NNS denotes results
T20224 39350-39355 VBN denotes shown
T20225 39356-39358 IN denotes in
T20226 39359-39360 -LRB- denotes (
T20227 39360-39361 NNP denotes E
T20228 39361-39362 -RRB- denotes )
T20229 39363-39366 VBP denotes are
T20230 39367-39381 NN denotes representative
T20231 39382-39384 IN denotes of
T20232 39385-39392 NNS denotes samples
T20233 39393-39397 IN denotes from
T20234 39398-39401 CD denotes two
T20235 39402-39414 NNS denotes participants
T20236 39414-39415 . denotes .
R374 T484 T488 nmod interleukin,-4
R375 T477 T476 prep in,role
R376 T478 T477 pcomp regulating,in
R377 T479 T480 det the,expression
R378 T480 T478 dobj expression,regulating
R379 T485 T484 punct (,interleukin
R380 T481 T480 prep of,expression
R381 T482 T483 det the,cytokines
R382 T483 T481 pobj cytokines,of
R383 T486 T484 appos IL,interleukin
R384 T487 T484 punct ),interleukin
R385 T488 T473 npadvmod -4,plays
R386 T489 T488 punct ",",-4
R387 T490 T488 conj IL-5,-4
R398 T590 T589 amod independent,mechanism
R400 T591 T590 prep of,independent
R401 T592 T593 amod nuclear,factor-κB
R403 T593 T591 pobj factor-κB,of
R404 T594 T577 cc and,inhibits
R405 T595 T577 conj is,inhibits
R436 T516 T515 pcomp suppressing,in
R444 T517 T518 amod allergic,inflammation
R446 T621 T623 punct ",",induces
R447 T622 T623 nsubj fluticasone,induces
R448 T518 T516 dobj inflammation,suppressing
R449 T623 T623 ROOT induces,induces
R450 T624 T625 det the,expression
R451 T625 T623 dobj expression,induces
R452 T519 T512 punct ",",are
R453 T626 T625 prep of,expression
R454 T627 T629 amod mitogen-activated,kinase
R455 T628 T629 compound protein,kinase
R456 T520 T512 cc but,are
R457 T629 T626 pobj kinase,of
R458 T630 T631 punct (,MAPK
R459 T631 T629 appos MAPK,kinase
R460 T632 T629 punct ),kinase
R461 T633 T625 appos phosphatase-1,expression
R462 T634 T633 punct (,phosphatase-1
R463 T521 T522 poss their,effects
R464 T635 T633 appos MKP-1,phosphatase-1
R465 T636 T633 punct ),phosphatase-1
R466 T637 T633 punct ",",phosphatase-1
R467 T522 T525 nsubj effects,are
R468 T638 T640 det the,inhibitor
R469 T639 T640 amod endogenous,inhibitor
R470 T640 T633 appos inhibitor,phosphatase-1
R471 T523 T522 prep on,effects
R472 T641 T640 prep of,inhibitor
R473 T642 T643 nummod p38,MAPK
R474 T524 T523 pobj GATA-3,on
R475 T643 T641 pobj MAPK,of
R476 T644 T643 punct ",",MAPK
R477 T645 T646 nsubj which,is
R478 T646 T643 relcl is,MAPK
R479 T525 T512 conj are,are
R480 T647 T646 acomp necessary,is
R481 T648 T647 prep for,necessary
R482 T526 T525 acomp unknown,are
R483 T527 T525 punct .,are
R484 T528 T529 nsubj We,investigated
R485 T529 T529 ROOT investigated,investigated
R486 T649 T651 amod GATA-3,translocation
R487 T530 T531 det the,effect
R488 T531 T529 dobj effect,investigated
R489 T532 T531 prep of,effect
R490 T533 T536 det the,propionate
R491 T534 T536 amod corticosteroid,propionate
R492 T650 T651 amod nuclear,translocation
R493 T535 T536 compound fluticasone,propionate
R494 T536 T532 pobj propionate,of
R495 T537 T536 prep on,propionate
R496 T538 T539 amod GATA-3,regulation
R497 T539 T537 pobj regulation,on
R498 T540 T539 prep in,regulation
R499 T651 T648 pobj translocation,for
R500 T541 T542 amod human,T-lymphocytes
R501 T542 T540 pobj T-lymphocytes,in
R502 T543 T539 prep in,regulation
R503 T544 T543 pobj vitro,in
R504 T545 T543 cc and,in
R506 T546 T543 conj in,in
R508 T547 T546 pobj vivo,in
R511 T548 T529 punct .,investigated
R512 T549 T549 ROOT Methods,Methods
R514 T550 T549 cc and,Methods
R518 T551 T549 conj Findings,Methods
R522 T552 T574 prep In,demonstrated
R526 T553 T557 det a,line
R529 T554 T557 compound T,line
R534 T555 T557 compound lymphocyte,line
R537 T556 T557 compound cell,line
R541 T557 T552 pobj line,In
R545 T558 T559 punct (,HuT-78
R548 T559 T565 amod HuT-78,cells
R550 T560 T559 punct ),HuT-78
R551 T561 T559 cc and,HuT-78
R552 T562 T565 amod peripheral,cells
R553 T563 T564 compound blood,mononuclear
R556 T564 T565 compound mononuclear,cells
R562 T565 T574 nsubj cells,demonstrated
R565 T566 T565 acl stimulated,cells
R569 T567 T566 agent by,stimulated
R572 T568 T574 advcl anti-CD3,demonstrated
R573 T569 T568 cc and,anti-CD3
R574 T570 T568 conj anti-CD28,anti-CD3
R575 T571 T574 prep in,demonstrated
R577 T572 T571 pobj vitro,in
R581 T573 T574 nsubj we,demonstrated
R584 T574 T574 ROOT demonstrated,demonstrated
R588 T575 T577 mark that,inhibits
R592 T576 T577 nsubj fluticasone,inhibits
R596 T577 T574 ccomp inhibits,demonstrated
R600 T578 T579 amod nuclear,translocation
R603 T579 T577 dobj translocation,inhibits
R604 T717 T720 det the,efficacy
R605 T580 T579 prep of,translocation
R606 T581 T580 pobj GATA-3,of
R607 T582 T579 cc and,translocation
R608 T583 T579 conj expression,translocation
R609 T584 T583 prep of,expression
R610 T585 T586 amod Th2,cytokines
R611 T586 T584 pobj cytokines,of
R612 T718 T720 amod striking,efficacy
R613 T587 T577 prep via,inhibits
R614 T719 T720 amod clinical,efficacy
R615 T720 T716 pobj efficacy,for
R616 T588 T589 det a,mechanism
R617 T721 T720 prep of,efficacy
R618 T722 T721 pobj corticosteroids,of
R619 T589 T587 pobj mechanism,via
R620 T723 T722 prep in,corticosteroids
R621 T724 T725 det the,treatment
R622 T725 T723 pobj treatment,in
R624 T726 T725 prep of,treatment
R625 T727 T728 amod allergic,diseases
R784 T459 T458 cc and,Import
R785 T460 T458 conj Phosphorylation,Import
R786 T461 T454 punct :,Suppression
R787 T462 T464 compound A,Mechanism
R788 T463 T464 compound Novel,Mechanism
R789 T464 T454 appos Mechanism,Suppression
R790 T465 T464 prep of,Mechanism
R791 T466 T467 compound Corticosteroid,Action
R792 T467 T465 pobj Action,of
R793 T468 T467 prep in,Action
R794 T469 T468 pobj Allergic,in
R795 T470 T472 compound Disease,GATA-3
R796 T471 T472 compound Background,GATA-3
R797 T472 T473 nsubj GATA-3,plays
R798 T473 T473 ROOT plays,plays
R799 T474 T476 det a,role
R800 T475 T476 amod critical,role
R801 T476 T473 dobj role,plays
R3612 T4177 T4174 punct ),GATA-3
R3613 T4178 T4174 cc and,GATA-3
R3614 T4179 T4174 conj GR,GATA-3
R3615 T4180 T4181 punct (,E-20
R3616 T4181 T4174 conj E-20,GATA-3
R3617 T4182 T4181 punct ",",E-20
R3618 T4183 T4181 amod sc-1003,E-20
R3619 T4184 T4181 punct ),E-20
R3620 T4185 T4186 auxpass were,obtained
R3621 T4186 T4186 ROOT obtained,obtained
R3622 T4187 T4186 prep from,obtained
R3623 T4188 T4190 compound Santa,Biotechnology
R3624 T4189 T4190 compound Cruz,Biotechnology
R3625 T4190 T4187 pobj Biotechnology,from
R3626 T4191 T4190 punct (,Biotechnology
R1977 T2289 T2287 cc and,rhinitis
R1978 T2290 T2291 amod atopic,dermatitis
R1979 T2291 T2287 conj dermatitis,rhinitis
R1980 T2292 T2293 auxpass is,mediated
R1981 T2293 T2293 ROOT mediated,mediated
R1982 T2294 T2293 prep via,mediated
R1983 T2295 T2294 pobj expression,via
R1984 T2296 T2295 prep of,expression
R1985 T2297 T2298 det the,cytokines
R1986 T2298 T2296 pobj cytokines,of
R1987 T2299 T2293 conj interleukin,mediated
R1988 T2300 T2301 punct (,IL
R1989 T2301 T2299 appos IL,interleukin
R1990 T2302 T2301 punct ),IL
R1991 T2303 T2301 nummod -4,IL
R1992 T2327 T2325 pobj lymphocytes,from
R1993 T2304 T2301 punct ",",IL
R1994 T2328 T2320 punct ",",regulate
R1995 T2305 T2301 appos IL-5,IL
R1996 T2306 T2305 punct ",",IL-5
R1997 T2329 T2331 mark whereas,plays
R1998 T2307 T2305 cc and,IL-5
R1999 T2330 T2331 nsubj IL-5,plays
R2000 T2331 T2320 advcl plays,regulate
R2001 T2308 T2305 conj IL-13,IL-5
R2002 T2332 T2334 det a,role
R2003 T2333 T2334 amod key,role
R2004 T2334 T2331 dobj role,plays
R2005 T2335 T2334 prep in,role
R2006 T2309 T2308 prep from,IL-13
R2007 T2336 T2337 amod eosinophilic,inflammation
R2008 T2337 T2335 pobj inflammation,in
R2009 T2310 T2311 compound T,helper-2
R2010 T2338 T2340 quantmod [,]
R2011 T2339 T2340 nummod 1,]
R2012 T2340 T2331 npadvmod ],plays
R2013 T2311 T2309 pobj helper-2,from
R2014 T2341 T2320 punct .,regulate
R2015 T2342 T2343 nummod Th2,cytokines
R2016 T2343 T2345 nsubjpass cytokines,regulated
R2017 T2312 T2311 punct (,helper-2
R2018 T2344 T2345 auxpass are,regulated
R2019 T2313 T2311 appos Th2,helper-2
R2020 T2314 T2311 punct ),helper-2
R2021 T2315 T2309 pobj cells,from
R2022 T2345 T2345 ROOT regulated,regulated
R2023 T2346 T2345 agent by,regulated
R2024 T2347 T2351 det the,factor
R2025 T2348 T2350 compound zinc,transcription
R2026 T2349 T2350 compound finger,transcription
R2027 T2316 T2293 punct .,mediated
R2028 T2350 T2351 compound transcription,factor
R2029 T2351 T2346 pobj factor,by
R2030 T2317 T2320 nsubj IL-4,regulate
R2031 T2352 T2351 appos GATA-3,factor
R2032 T2353 T2351 punct ",",factor
R2033 T2354 T2357 nsubjpass which,expressed
R2034 T2318 T2317 cc and,IL-4
R2035 T2355 T2357 auxpass is,expressed
R2036 T2356 T2357 advmod predominantly,expressed
R2037 T2357 T2351 relcl expressed,factor
R2038 T2319 T2317 conj IL-13,IL-4
R2039 T2358 T2357 prep in,expressed
R2040 T2320 T2320 ROOT regulate,regulate
R2041 T2321 T2322 det the,expression
R2042 T2359 T2360 amod Th2,cells
R2043 T2322 T2320 dobj expression,regulate
R2044 T2360 T2358 pobj cells,in
R2045 T2361 T2363 nmod [,]
R2046 T2362 T2363 nummod 2,]
R2047 T2363 T2367 nmod ],]
R2048 T2323 T2322 prep of,expression
R2049 T2364 T2363 punct ",",]
R2050 T2324 T2323 pobj IgE,of
R2051 T2325 T2320 prep from,regulate
R2052 T2365 T2363 conj [,]
R2053 T2326 T2327 compound B,lymphocytes
R2054 T2366 T2367 nummod 3,]
R2055 T2367 T2345 npadvmod ],regulated
R2056 T2368 T2345 punct .,regulated
R2057 T2456 T2454 pobj cytokines,of
R2058 T2369 T2370 nsubj GATA-3,determines
R2059 T2370 T2370 ROOT determines,determines
R2060 T2371 T2373 compound Th2,differentiation
R2061 T2372 T2373 compound cell,differentiation
R2062 T2457 T2452 prep in,reduces
R2063 T2373 T2370 dobj differentiation,determines
R2064 T2374 T2370 cc and,determines
R2065 T2375 T2376 advmod selectively,activates
R2066 T2458 T2457 pobj vitro,in
R2067 T2376 T2370 conj activates,determines
R2068 T2377 T2378 det the,promoters
R2069 T2378 T2376 dobj promoters,activates
R2070 T2459 T2457 cc and,in
R2071 T2379 T2378 prep of,promoters
R2072 T2380 T2379 pobj IL-4,of
R2073 T2381 T2380 punct ",",IL-4
R2074 T2382 T2380 conj IL-5,IL-4
R2075 T2383 T2382 punct ",",IL-5
R2076 T2384 T2382 cc and,IL-5
R2077 T2385 T2382 conj IL-13,IL-5
R2078 T2460 T2457 conj in,in
R2079 T2386 T2376 prep through,activates
R2080 T2387 T2388 compound chromatin,remodelling
R2081 T2388 T2389 compound remodelling,[
R2082 T2389 T2391 nmod [,]
R2083 T2461 T2460 pobj vivo,in
R2084 T2390 T2391 nummod 4,]
R2085 T2391 T2386 pobj ],through
R2086 T2392 T2394 nmod [,]
R2087 T2462 T2464 nmod [,]
R2088 T2393 T2392 nummod 7,[
R2089 T2394 T2391 appos ],]
R2090 T2463 T2464 nummod 10,]
R2091 T2395 T2370 punct .,determines
R2092 T2396 T2398 det The,role
R2093 T2397 T2398 amod key,role
R2094 T2464 T2452 dobj ],reduces
R2095 T2398 T2407 nsubjpass role,demonstrated
R2096 T2399 T2398 prep of,role
R2097 T2400 T2399 pobj GATA-3,of
R2098 T2465 T2464 punct ",",]
R2099 T2401 T2400 prep in,GATA-3
R2100 T2402 T2404 amod allergic,inflammation
R2101 T2403 T2404 compound airway,inflammation
R2102 T2466 T2464 cc and,]
R2103 T2404 T2401 pobj inflammation,in
R2104 T2405 T2407 aux has,demonstrated
R2105 T2406 T2407 auxpass been,demonstrated
R2106 T2407 T2407 ROOT demonstrated,demonstrated
R2107 T2467 T2468 amod similar,results
R2108 T2408 T2407 prep in,demonstrated
R2109 T2409 T2408 pobj mice,in
R2110 T2468 T2464 conj results,]
R2111 T2410 T2407 agent by,demonstrated
R2112 T2469 T2471 aux have,reported
R2113 T2411 T2413 det the,release
R2114 T2470 T2471 auxpass been,reported
R2115 T2412 T2413 amod reduced,release
R2116 T2471 T2452 conj reported,reduces
R2117 T2413 T2410 pobj release,by
R2118 T2414 T2413 prep of,release
R2119 T2415 T2416 amod Th2,cytokines
R2120 T2472 T2471 prep in,reported
R2121 T2416 T2414 pobj cytokines,of
R2122 T2417 T2416 prep in,cytokines
R2123 T2418 T2417 pobj animals,in
R2124 T2473 T2474 amod isolated,murine
R2125 T2419 T2418 acl treated,animals
R2126 T2420 T2419 prep with,treated
R2127 T2421 T2422 amod dominant-negative,mutants
R2128 T2474 T2472 pobj murine,in
R2129 T2422 T2420 pobj mutants,with
R2130 T2423 T2422 prep of,mutants
R2131 T2475 T2476 compound CD4,+
R2132 T2476 T2477 nsubj +,lymphocytes
R2133 T2424 T2423 pobj GATA-3,of
R2134 T2425 T2420 cc and,with
R2135 T2426 T2419 agent by,treated
R2136 T2477 T2471 parataxis lymphocytes,reported
R2137 T2427 T2428 amod local,application
R2138 T2428 T2426 pobj application,by
R2139 T2429 T2428 prep of,application
R2140 T2478 T2480 nmod [,]
R2141 T2430 T2431 amod antisense,oligonucleotides
R2142 T2431 T2429 pobj oligonucleotides,of
R2143 T2479 T2480 nummod 11,]
R2144 T2432 T2419 prep to,treated
R2145 T2433 T2436 nmod GATA-3,]
R2146 T2434 T2436 nmod [,]
R2147 T2480 T2477 dobj ],lymphocytes
R2148 T2435 T2436 nummod 8,]
R2149 T2436 T2432 pobj ],to
R2150 T2437 T2436 punct ",",]
R2151 T2438 T2440 nmod [,]
R2152 T2481 T2477 punct .,lymphocytes
R2153 T2439 T2440 nummod 9,]
R2154 T2440 T2436 appos ],]
R2155 T2482 T2488 advmod Finally,using
R2156 T2441 T2407 punct .,demonstrated
R2157 T2442 T2452 advmod Furthermore,reduces
R2158 T2443 T2445 punct ",",knock-out
R2159 T2483 T2488 punct ",",using
R2160 T2444 T2445 amod conditional,knock-out
R2161 T2445 T2452 nsubj knock-out,reduces
R2162 T2446 T2445 prep of,knock-out
R3627 T4192 T4193 compound Santa,Cruz
R3628 T4193 T4190 appos Cruz,Biotechnology
R3629 T4194 T4193 punct ",",Cruz
R3630 T4195 T4193 conj California,Cruz
R3631 T4196 T4195 punct ",",California
R3632 T4197 T4198 compound United,States
R3633 T4198 T4195 appos States,California
R3634 T4199 T4195 punct ),California
R3635 T4200 T4190 punct ",",Biotechnology
R3636 T4201 T4203 amod polyclonal,antibodies
R3637 T4202 T4203 compound rabbit,antibodies
R3638 T4203 T4186 dobj antibodies,obtained
R3639 T4204 T4186 prep against,obtained
R3640 T4205 T4207 amod phospho-p38,kinase
R3641 T4206 T4207 compound MAP,kinase
R3642 T4207 T4204 pobj kinase,against
R3643 T4208 T4207 cc and,kinase
R3644 T4209 T4207 conj phospho-ATF-2,kinase
R3645 T4210 T4207 prep from,kinase
R3646 T4211 T4212 compound Cell,Signaling
R3647 T4212 T4210 pobj Signaling,from
R3648 T4213 T4225 nmod Technology,antibody
R3649 T4214 T4217 punct (,Biolabs
R3650 T4215 T4217 compound New,Biolabs
R3651 T4216 T4217 compound England,Biolabs
R3652 T4217 T4213 appos Biolabs,Technology
R3653 T4218 T4217 punct ",",Biolabs
R3654 T4219 T4217 conj Hertford,Biolabs
R3655 T4220 T4219 punct ",",Hertford
R3656 T4221 T4219 conj UK,Hertford
R3657 T4222 T4217 punct ),Biolabs
R3658 T4223 T4217 punct ",",Biolabs
R3659 T4224 T4225 amod monoclonal,antibody
R3660 T4225 T4243 nsubj antibody,antibodies
R3661 T4226 T4225 prep against,antibody
R3662 T4227 T4226 pobj phosphoserine,against
R3663 T4228 T4230 punct (,4H4
R3664 T4229 T4230 compound clone,4H4
R3665 T4230 T4227 appos 4H4,phosphoserine
R3666 T4231 T4230 punct ),4H4
R3667 T4232 T4230 prep from,4H4
R3668 T4233 T4235 compound Affiniti,Products
R3669 T4234 T4235 compound Research,Products
R3670 T4235 T4232 pobj Products,from
R3671 T4236 T4235 punct (,Products
R3672 T4237 T4235 npadvmod Exeter,Products
R3673 T4238 T4237 punct ",",Exeter
R3674 T4239 T4237 appos UK,Exeter
R3675 T4240 T4237 punct ),Exeter
R3676 T4241 T4235 punct ",",Products
R3677 T4242 T4227 cc and,phosphoserine
R3678 T4243 T4212 dobj antibodies,Signaling
R3679 T4244 T4243 prep against,antibodies
R3680 T4245 T4247 compound rabbit,TRITC
R3681 T4246 T4247 compound IgG-conjugated,TRITC
R3682 T4247 T4244 pobj TRITC,against
R3683 T4248 T4247 prep from,TRITC
R3684 T4249 T4250 compound Dako,Cytomation
R3685 T4250 T4248 pobj Cytomation,from
R3686 T4251 T4250 punct (,Cytomation
R3687 T4252 T4250 appos Cambridge,Cytomation
R3688 T4253 T4252 punct ",",Cambridge
R3689 T4254 T4252 appos UK,Cambridge
R3690 T4255 T4252 punct ),Cambridge
R3691 T4256 T4186 punct .,obtained
R3692 T4257 T4259 det The,antibody
R3693 T4258 T4259 amod anti-GR,antibody
R3694 T4259 T4274 nsubjpass antibody,used
R3695 T4260 T4259 punct (,antibody
R3696 T4261 T4259 appos Clone,antibody
R3697 T4262 T4261 nummod 41,Clone
R3698 T4263 T4261 punct ),Clone
R3699 T4264 T4259 prep from,antibody
R3700 T4265 T4267 compound BD,Laboratories
R3701 T4266 T4267 compound Transduction,Laboratories
R2163 T2484 T2488 nsubj knockdown,using
R2164 T2447 T2449 det the,gene
R2165 T2448 T2449 compound Gata3,gene
R2166 T2449 T2446 pobj gene,of
R2167 T2450 T2445 prep in,knock-out
R2168 T2485 T2484 prep of,knockdown
R2169 T2451 T2450 pobj mice,in
R2170 T2452 T2452 ROOT reduces,reduces
R2171 T2486 T2487 amod GATA-3,expression
R2172 T2453 T2452 dobj expression,reduces
R2173 T2454 T2453 prep of,expression
R2174 T2455 T2456 compound Th2,cytokines
R2175 T2487 T2485 pobj expression,of
R2176 T2488 T2488 ROOT using,using
R2177 T2489 T2488 dobj siRNA,using
R2178 T2490 T2488 prep in,using
R2179 T2491 T2493 amod human,cells
R2180 T2553 T2555 auxpass was,confirmed
R2181 T2554 T2555 advmod recently,confirmed
R2182 T2492 T2493 compound T,cells
R2183 T2555 T2544 conj confirmed,demonstrated
R2184 T2556 T2555 prep in,confirmed
R2185 T2557 T2559 amod human,cells
R2186 T2493 T2494 compound cells,results
R2187 T2558 T2559 compound T,cells
R2188 T2559 T2556 pobj cells,in
R2189 T2560 T2555 prep following,confirmed
R2190 T2494 T2490 pobj results,in
R2191 T2561 T2563 compound T,receptor
R2192 T2562 T2563 compound cell,receptor
R2193 T2563 T2560 pobj receptor,following
R2194 T2495 T2494 prep in,results
R2195 T2564 T2563 cc and,receptor
R2196 T2565 T2566 compound co-receptor,stimulation
R2197 T2496 T2495 pobj loss,in
R2198 T2566 T2563 conj stimulation,receptor
R2199 T2567 T2569 nmod [,]
R2200 T2568 T2569 nummod 12,]
R2201 T2497 T2496 prep of,loss
R2202 T2569 T2566 nmod ],stimulation
R2203 T2570 T2544 punct .,demonstrated
R2204 T2571 T2572 nsubj GATA-3,contains
R2205 T2498 T2503 amod anti-CD3,expression
R2206 T2499 T2503 nmod /,expression
R2207 T2572 T2572 ROOT contains,contains
R2208 T2500 T2503 nmod CD28-mediated,expression
R2209 T2573 T2577 det a,signal
R2210 T2574 T2577 amod classical,signal
R2211 T2501 T2503 amod Th2,expression
R2212 T2575 T2576 amod nuclear,import
R2213 T2576 T2577 compound import,signal
R2214 T2577 T2572 dobj signal,contains
R2215 T2502 T2503 compound cytokine,expression
R2216 T2578 T2580 nmod [,]
R2217 T2579 T2580 nummod 14,]
R2218 T2580 T2577 appos ],signal
R2219 T2503 T2497 pobj expression,of
R2220 T2581 T2572 cc and,contains
R2221 T2504 T2506 nmod [,]
R2222 T2582 T2583 auxpass is,transported
R2223 T2505 T2506 nummod 12,]
R2224 T2583 T2572 conj transported,contains
R2225 T2584 T2583 prep into,transported
R2226 T2585 T2586 det the,nucleus
R2227 T2586 T2584 pobj nucleus,into
R2228 T2587 T2583 agent by,transported
R2229 T2506 T2503 appos ],expression
R2230 T2588 T2591 det the,protein
R2231 T2589 T2591 amod nuclear,protein
R2232 T2590 T2591 compound import,protein
R2233 T2507 T2488 punct .,using
R2234 T2591 T2587 pobj protein,by
R2235 T2592 T2583 conj importin-α,transported
R2236 T2593 T2595 punct (,known
R2237 T2508 T2519 prep In,translocate
R2238 T2594 T2595 advmod also,known
R2239 T2595 T2592 acl known,importin-α
R2240 T2596 T2595 prep as,known
R2241 T2509 T2508 pobj order,In
R2242 T2597 T2596 pobj karyopherin-α,as
R2243 T2598 T2592 punct ),importin-α
R2244 T2599 T2601 nmod [,]
R2245 T2510 T2513 mark for,regulate
R2246 T2600 T2601 nummod 12,]
R2247 T2601 T2572 dep ],contains
R2248 T2602 T2572 punct .,contains
R2249 T2511 T2513 nsubj GATA-3,regulate
R2250 T2603 T2622 nsubj Deletion,prevents
R2251 T2604 T2603 prep of,Deletion
R2252 T2605 T2606 det a,region
R2253 T2512 T2513 aux to,regulate
R2254 T2606 T2604 pobj region,of
R2255 T2607 T2606 acl encompassing,region
R2256 T2608 T2612 det the,sequence
R2257 T2513 T2509 advcl regulate,order
R2258 T2609 T2612 amod GATA-3,sequence
R2259 T2610 T2611 amod nuclear,localisation
R2260 T2514 T2515 compound gene,expression
R2261 T2611 T2612 compound localisation,sequence
R2262 T2515 T2513 dobj expression,regulate
R2263 T2612 T2607 dobj sequence,encompassing
R2264 T2613 T2612 punct (,sequence
R2265 T2614 T2612 appos NLS,sequence
R2266 T2516 T2519 punct ",",translocate
R2267 T2615 T2612 punct ),sequence
R2268 T2616 T2606 conj region,region
R2269 T2617 T2603 prep in,Deletion
R2270 T2517 T2519 nsubj it,translocate
R2271 T2618 T2617 pobj murine,in
R2272 T2619 T2618 cc and,murine
R2273 T2620 T2621 amod human,cells
R2274 T2518 T2519 aux must,translocate
R2275 T2621 T2618 conj cells,murine
R2276 T2622 T2622 ROOT prevents,prevents
R2277 T2623 T2625 poss its,localisation
R2278 T2624 T2625 amod nuclear,localisation
R2279 T2625 T2622 dobj localisation,prevents
R2280 T2519 T2519 ROOT translocate,translocate
R2281 T2626 T2628 nmod [,]
R2282 T2520 T2519 prep from,translocate
R2283 T2627 T2628 nummod 12,]
R2284 T2628 T2622 dobj ],prevents
R2285 T2629 T2628 punct ",",]
R2286 T2521 T2522 det the,cytoplasm
R2287 T2630 T2628 conj [,]
R2288 T2631 T2632 nummod 14,]
R2289 T2632 T2628 conj ],]
R2290 T2522 T2520 pobj cytoplasm,from
R2291 T2633 T2622 punct .,prevents
R2292 T2634 T2635 det The,affinity
R2293 T2635 T2642 nsubjpass affinity,regulated
R2294 T2523 T2519 prep into,translocate
R2295 T2636 T2635 prep of,affinity
R2296 T2637 T2638 det the,importin-α
R2297 T2638 T2636 pobj importin-α,of
R2298 T2524 T2525 det the,nucleus
R2299 T2639 T2640 compound NLS,interaction
R2300 T2640 T2642 nsubjpass interaction,regulated
R2301 T2641 T2642 auxpass is,regulated
R2302 T2525 T2523 pobj nucleus,into
R2303 T2642 T2642 ROOT regulated,regulated
R2304 T2643 T2642 agent by,regulated
R2305 T2644 T2645 compound phosphorylation,[
R2306 T2526 T2527 aux to,access
R2307 T2645 T2647 nmod [,]
R2308 T2646 T2647 nummod 15,]
R2309 T2647 T2643 pobj ],by
R2310 T2527 T2519 advcl access,translocate
R2311 T2648 T2642 punct ",",regulated
R2312 T2649 T2642 cc and,regulated
R2313 T2528 T2530 poss its,genes
R2314 T2529 T2530 compound target,genes
R2315 T2650 T2652 nsubj we,shown
R2316 T2530 T2527 dobj genes,access
R2317 T2651 T2652 aux have,shown
R2318 T2652 T2642 conj shown,regulated
R2319 T2653 T2661 mark that,plays
R2320 T2531 T2519 punct .,translocate
R2321 T2654 T2657 nummod p38,kinase
R2322 T2655 T2657 amod mitogen-activated,kinase
R2323 T2656 T2657 compound protein,kinase
R2324 T2532 T2534 amod Enhanced,expression
R2325 T2657 T2661 nsubj kinase,plays
R2326 T2658 T2659 punct (,MAPK
R2327 T2533 T2534 amod nuclear,expression
R2328 T2659 T2657 appos MAPK,kinase
R2329 T2660 T2657 punct ),kinase
R2330 T2534 T2544 nsubjpass expression,demonstrated
R2331 T2661 T2652 ccomp plays,shown
R2332 T2662 T2664 det a,role
R2333 T2663 T2664 amod critical,role
R2334 T2535 T2534 prep of,expression
R2335 T2664 T2661 dobj role,plays
R2336 T2665 T2664 prep in,role
R2337 T2536 T2535 pobj GATA-3,of
R2338 T2537 T2534 acl following,expression
R2341 T2538 T2541 compound T,activation
R2345 T2539 T2540 compound cell,receptor
R2350 T2540 T2541 compound receptor,activation
R2353 T2541 T2537 pobj activation,following
R2357 T2542 T2544 auxpass was,demonstrated
R2358 T2680 T2682 nmod [,]
R2359 T2681 T2682 nummod 12,]
R2360 T2682 T2679 appos ],nucleus
R2361 T2543 T2544 advmod first,demonstrated
R2362 T2683 T2652 punct .,shown
R2363 T2684 T2685 nsubj Corticosteroids,are
R2364 T2685 T2685 ROOT are,are
R2365 T2686 T2687 advmod highly,effective
R2366 T2544 T2544 ROOT demonstrated,demonstrated
R2367 T2687 T2685 acomp effective,are
R2368 T2688 T2687 prep in,effective
R2369 T2689 T2690 det the,treatment
R2370 T2545 T2544 prep in,demonstrated
R2371 T2690 T2688 pobj treatment,in
R2372 T2691 T2690 prep of,treatment
R2373 T2546 T2547 compound murine,T
R2374 T2692 T2693 amod allergic,inflammation
R2375 T2693 T2691 pobj inflammation,of
R2376 T2694 T2685 punct ",",are
R2377 T2695 T2685 prep with,are
R2378 T2696 T2697 amod marked,suppression
R2379 T2697 T2695 pobj suppression,with
R2380 T2547 T2548 compound T,cells
R2381 T2698 T2697 prep of,suppression
R2382 T2699 T2700 amod Th2,cytokines
R2383 T2700 T2698 pobj cytokines,of
R2384 T2701 T2697 prep in,suppression
R2385 T2548 T2545 pobj cells,in
R2386 T2702 T2701 pobj airways,in
R2387 T2703 T2702 prep of,airways
R2388 T2704 T2703 pobj patients,of
R2389 T2549 T2551 nmod [,]
R2390 T2705 T2704 prep with,patients
R2391 T2706 T2705 pobj asthma,with
R2392 T2707 T2709 quantmod [,]
R2393 T2550 T2551 nummod 13,]
R2394 T2708 T2709 nummod 16,]
R2395 T2709 T2685 npadvmod ],are
R2396 T2710 T2685 punct .,are
R2397 T2711 T2712 nsubj Corticosteroids,mediate
R2398 T2551 T2548 appos ],cells
R2399 T2712 T2712 ROOT mediate,mediate
R2400 T2713 T2715 poss their,effects
R2401 T2552 T2544 cc and,demonstrated
R2402 T2714 T2715 amod anti-inflammatory,effects
R2403 T2747 T2745 pobj genes,of
R2404 T2715 T2712 dobj effects,mediate
R2405 T2716 T2712 prep through,mediate
R2406 T2748 T2712 punct .,mediate
R2407 T2717 T2716 amod binding,through
R2408 T2749 T2751 advmod Alternatively,activated
R2409 T2718 T2717 prep to,binding
R2410 T2750 T2751 punct ",",activated
R2411 T2719 T2720 amod glucocorticoid,receptors
R2412 T2751 T2751 ROOT activated,activated
R2413 T2752 T2753 compound GR,interacts
R2414 T2720 T2718 pobj receptors,to
R2415 T2721 T2720 punct (,receptors
R2416 T2722 T2720 appos GRs,receptors
R2417 T2753 T2751 dobj interacts,activated
R2418 T2723 T2720 punct ),receptors
R2419 T2724 T2720 punct ",",receptors
R2420 T2725 T2727 nsubj which,translocate
R2421 T2754 T2753 prep with,interacts
R2422 T2726 T2727 advmod then,translocate
R2423 T2727 T2720 relcl translocate,receptors
R2424 T2755 T2756 compound coactivator,molecules
R2425 T2728 T2727 prep to,translocate
R2426 T2729 T2730 det the,nucleus
R2427 T2730 T2728 pobj nucleus,to
R2428 T2756 T2754 pobj molecules,with
R2429 T2731 T2733 advmod where,interact
R2430 T2757 T2758 aux to,suppress
R2431 T2732 T2733 nsubj they,interact
R2432 T2733 T2730 relcl interact,nucleus
R2433 T2734 T2733 prep with,interact
R2434 T2758 T2751 advcl suppress,activated
R2435 T2735 T2737 amod glucocorticoid,elements
R2436 T2736 T2737 compound response,elements
R2437 T2737 T2734 pobj elements,with
R2438 T2759 T2760 det the,expression
R2439 T2738 T2739 punct (,GREs
R2440 T2760 T2758 dobj expression,suppress
R2441 T2739 T2737 appos GREs,elements
R2442 T2740 T2737 punct ),elements
R2443 T2761 T2760 prep of,expression
R2444 T2741 T2733 prep in,interact
R2445 T2742 T2744 det the,regions
R2446 T2743 T2744 compound promoter,regions
R2447 T2762 T2763 amod inflammatory,genes
R2448 T2744 T2741 pobj regions,in
R2449 T2745 T2744 prep of,regions
R2450 T2746 T2747 amod steroid-sensitive,genes
R2451 T2763 T2761 pobj genes,of
R2452 T2764 T2758 prep by,suppress
R2453 T2765 T2764 pcomp inhibiting,by
R2454 T2766 T2767 det the,action
R2455 T2844 T2841 appos ],pathway
R2456 T2767 T2765 dobj action,inhibiting
R2457 T2845 T2820 punct .,signals
R2458 T2846 T2856 nsubj NL1,binds
R2459 T2768 T2767 prep of,action
R2460 T2847 T2846 punct ",",NL1
R2461 T2848 T2849 nsubj which,is
R2462 T2849 T2846 relcl is,NL1
R2463 T2769 T2771 amod proinflammatory,factors
R2464 T2850 T2849 acomp similar,is
R2465 T2851 T2850 prep to,similar
R2466 T2852 T2854 det the,NLS
R2467 T2770 T2771 compound transcription,factors
R2468 T2853 T2854 compound SV40,NLS
R2469 T2854 T2851 pobj NLS,to
R2470 T2855 T2849 punct ",",is
R2471 T2771 T2768 pobj factors,of
R2472 T2856 T2856 ROOT binds,binds
R2473 T2857 T2858 aux to,importin-α
R2474 T2858 T2856 xcomp importin-α,binds
R2475 T2772 T2773 amod such,as
R2476 T2859 T2858 dobj [,importin-α
R2477 T2860 T2861 nummod 22,]
R2478 T2861 T2856 npadvmod ],binds
R2479 T2862 T2856 punct .,binds
R2480 T2863 T2865 nsubjpass NL1,activated
R2481 T2864 T2865 auxpass is,activated
R2482 T2773 T2771 prep as,factors
R2483 T2865 T2865 ROOT activated,activated
R2484 T2866 T2867 advmod both,by
R2485 T2867 T2865 agent by,activated
R2486 T2868 T2869 amod glucocorticoid,agonists
R2487 T2774 T2775 amod nuclear,factor-κB
R2488 T2869 T2867 pobj agonists,by
R2489 T2775 T2773 pobj factor-κB,as
R2490 T2870 T2871 amod such,as
R2491 T2871 T2869 prep as,agonists
R2492 T2872 T2871 pobj dexamethasone,as
R2493 T2873 T2872 cc and,dexamethasone
R2494 T2776 T2775 punct (,factor-κB
R2495 T2874 T2875 compound fluticasone,propionate
R2496 T2875 T2872 conj propionate,dexamethasone
R2497 T2876 T2877 punct (,FP
R2498 T2877 T2875 appos FP,propionate
R2499 T2777 T2775 appos NF-κB,factor-κB
R2500 T2878 T2877 punct ),FP
R2501 T2879 T2867 cc and,by
R2502 T2880 T2867 conj by,by
R2503 T2778 T2775 punct ),factor-κB
R2504 T2779 T2765 prep through,inhibiting
R2505 T2881 T2882 amod glucocorticoid,antagonists
R2506 T2780 T2781 det the,recruitment
R2507 T2781 T2779 pobj recruitment,through
R2508 T2882 T2880 pobj antagonists,by
R2509 T2782 T2781 prep of,recruitment
R2510 T2883 T2884 amod such,as
R2511 T2783 T2784 compound co-repressor,molecules
R2512 T2784 T2782 pobj molecules,of
R2513 T2884 T2882 prep as,antagonists
R2514 T2885 T2884 pobj mifepristone,as
R2515 T2785 T2786 amod such,as
R2516 T2886 T2885 punct (,mifepristone
R2517 T2887 T2889 nmod RU486,[
R2518 T2888 T2889 punct ),[
R2519 T2786 T2784 prep as,molecules
R2520 T2889 T2865 npadvmod [,activated
R2521 T2890 T2891 nummod 23,]
R2522 T2891 T2889 appos ],[
R2523 T2787 T2789 compound histone,[
R2524 T2892 T2865 punct .,activated
R2525 T2893 T2896 nsubjpass NL1,mutated
R2526 T2788 T2789 compound deacetylase-2,[
R2527 T2894 T2896 aux can,mutated
R2528 T2789 T2786 pobj [,as
R2529 T2895 T2896 auxpass be,mutated
R2530 T2896 T2896 ROOT mutated,mutated
R2531 T2790 T2791 nummod 17,]
R2532 T2897 T2896 punct ",",mutated
R2533 T2898 T2896 cc and,mutated
R2534 T2899 T2901 det the,GR
R2535 T2791 T2789 conj ],[
R2536 T2900 T2901 amod resulting,GR
R2537 T2901 T2903 nsubj GR,translocates
R2538 T2902 T2903 advmod still,translocates
R2539 T2792 T2791 punct ",",]
R2540 T2903 T2896 conj translocates,mutated
R2541 T2904 T2903 prep to,translocates
R2542 T2905 T2906 det the,nucleus
R2543 T2793 T2791 conj [,]
R2544 T2906 T2904 pobj nucleus,to
R2545 T2907 T2903 prep in,translocates
R2546 T2908 T2907 pobj response,in
R2547 T2794 T2795 nummod 18,]
R2548 T2909 T2908 prep to,response
R2549 T2910 T2909 pobj ligands,to
R2550 T2911 T2903 punct ",",translocates
R2551 T2795 T2791 conj ],]
R2552 T2912 T2903 cc but,translocates
R2553 T2913 T2903 conj via,translocates
R2554 T2914 T2913 pobj interaction,via
R2555 T2796 T2751 punct .,activated
R2556 T2915 T2914 prep with,interaction
R2557 T2916 T2915 pobj importin,with
R2558 T2917 T2916 nummod 7,importin
R2559 T2797 T2798 compound Nuclear,localisation
R2560 T2918 T2916 punct ",",importin
R2561 T2919 T2920 det an,event
R2562 T2920 T2916 appos event,importin
R2563 T2798 T2804 nsubjpass localisation,mediated
R2564 T2921 T2922 nsubj that,requires
R2565 T2922 T2920 relcl requires,event
R2566 T2923 T2926 det an,component
R2567 T2799 T2798 cc and,localisation
R2568 T2924 T2925 advmod as-yet,unknown
R2569 T2925 T2926 amod unknown,component
R2570 T2926 T2922 dobj component,requires
R2571 T2800 T2798 conj retention,localisation
R2572 T2927 T2926 appos [,component
R2573 T2801 T2800 prep of,retention
R2574 T2928 T2929 nummod 23,]
R2575 T2929 T2922 dobj ],requires
R2576 T2802 T2801 pobj GR,of
R2577 T2930 T2903 punct .,translocates
R2578 T2931 T2934 nsubjpass NL2,defined
R2579 T2932 T2934 auxpass is,defined
R2580 T2933 T2934 advmod poorly,defined
R2581 T2934 T2934 ROOT defined,defined
R2582 T2935 T2934 punct ",",defined
R2583 T2803 T2804 auxpass is,mediated
R2584 T2936 T2934 advcl residing,defined
R2585 T2937 T2936 prep in,residing
R2586 T2938 T2940 det the,domain
R2587 T2804 T2820 ccomp mediated,signals
R2588 T2939 T2940 amod ligand-binding,domain
R2589 T2940 T2937 pobj domain,in
R2590 T2805 T2804 prep through,mediated
R2591 T2806 T2809 det the,sequences
R2592 T2807 T2808 amod nuclear,localisation
R2593 T2941 T2934 punct ",",defined
R2594 T2808 T2809 compound localisation,sequences
R2595 T2942 T2934 cc and,defined
R2596 T2943 T2944 advmod much,less
R2597 T2944 T2946 advmod less,known
R2598 T2809 T2805 pobj sequences,through
R2599 T2945 T2946 auxpass is,known
R2600 T2946 T2934 conj known,defined
R2601 T2947 T2946 prep about,known
R2602 T2810 T2809 appos NL1,sequences
R2603 T2948 T2949 poss its,mechanism
R2604 T2949 T2947 pobj mechanism,about
R2605 T2950 T2949 prep of,mechanism
R2606 T2811 T2810 cc and,NL1
R2607 T2951 T2953 compound GR,[
R2608 T2952 T2953 compound import,[
R2609 T2953 T2950 pobj [,of
R2610 T2812 T2813 compound NL2,[
R2611 T2954 T2955 nummod 24,]
R2612 T2955 T2949 appos ],mechanism
R2613 T2956 T2934 punct .,defined
R2614 T2813 T2810 conj [,NL1
R2615 T2957 T2958 det A,variety
R2616 T2958 T2962 nsubj variety,are
R2617 T2959 T2958 prep of,variety
R2618 T2814 T2815 nummod 19,]
R2619 T2960 T2961 amod other,factors
R2620 T2961 T2959 pobj factors,of
R2621 T2962 T2962 ROOT are,are
R2622 T2815 T2810 conj ],NL1
R2623 T2963 T2962 advmod also,are
R2624 T2964 T2962 acomp important,are
R2625 T2965 T2964 prep for,important
R2626 T2816 T2804 punct ",",mediated
R2627 T2966 T2967 det the,regulation
R2628 T2967 T2965 pobj regulation,for
R2629 T2968 T2967 prep of,regulation
R2630 T2969 T2970 compound GR,activation
R2631 T2970 T2968 pobj activation,of
R2632 T2817 T2804 agent by,mediated
R2633 T2971 T2970 cc and,activation
R2634 T2818 T2819 amod nuclear,retention
R2635 T2972 T2973 amod nuclear,import
R2636 T2819 T2817 pobj retention,by
R2637 T2973 T2970 conj import,activation
R2638 T2974 T2967 prep including,regulation
R2639 T2975 T2974 pobj chaperones,including
R2640 T2820 T2820 ROOT signals,signals
R2641 T2976 T2977 amod such,as
R2642 T2821 T2823 nmod [,]
R2643 T2822 T2823 nummod 20,]
R2644 T2977 T2975 prep as,chaperones
R2645 T2823 T2820 dobj ],signals
R2646 T2824 T2820 punct ",",signals
R2647 T2978 T2990 nmod Hsp90,proteins
R2648 T2825 T2820 cc and,signals
R2649 T2979 T2978 cc and,Hsp90
R2650 T2826 T2820 conj by,signals
R2651 T2827 T2826 pobj control,by
R2652 T2980 T2981 amod other,immunophilins
R2653 T2828 T2827 prep of,control
R2654 T2981 T2978 conj immunophilins,Hsp90
R2655 T2829 T2830 amod nuclear,export
R2656 T2982 T2978 conj [,Hsp90
R2657 T2830 T2828 pobj export,of
R2658 T2983 T2984 nummod 24,]
R2659 T2984 T2978 conj ],Hsp90
R2660 T2831 T2820 prep via,signals
R2661 T2985 T2978 conj [,Hsp90
R2662 T2986 T2987 nummod 26,]
R2663 T2832 T2841 det a,pathway
R2664 T2987 T2990 nmod ],proteins
R2665 T2988 T2987 cc and,]
R2666 T2989 T2990 amod FK506-binding,proteins
R2667 T2833 T2834 amod chromosomal,region
R2668 T2990 T2977 pobj proteins,as
R2669 T2991 T2994 nsubjpass that,linked
R2670 T2992 T2994 aux may,linked
R2671 T2834 T2835 compound region,maintenance
R2672 T2993 T2994 auxpass be,linked
R2673 T2994 T2990 relcl linked,proteins
R2674 T2995 T2996 aux to,dynein
R2675 T2996 T2994 xcomp dynein,linked
R2676 T2835 T2841 nmod maintenance,pathway
R2677 T2997 T2996 cc and/or,dynein
R2678 T2998 T2996 conj peptidylprolyl,dynein
R2679 T2999 T3000 compound isomerase,[
R2680 T3000 T2998 dobj [,peptidylprolyl
R2681 T3001 T3002 nummod 27,]
R2682 T3002 T2998 npadvmod ],peptidylprolyl
R2683 T2836 T2835 nummod 1,maintenance
R2684 T3003 T3002 punct ",",]
R2685 T3004 T3002 appos [,]
R2686 T3005 T3006 nummod 28,]
R2687 T2837 T2835 punct (,maintenance
R2688 T3006 T3002 appos ],]
R2689 T3007 T2962 punct .,are
R2690 T3008 T3021 advmod However,is
R2691 T2838 T2835 appos CRM-1,maintenance
R2692 T3009 T3021 punct ",",is
R2693 T3010 T3012 det the,basis
R2694 T3011 T3012 amod molecular,basis
R2695 T2839 T2835 punct ),maintenance
R2696 T3012 T3021 nsubj basis,is
R2697 T3013 T3012 prep for,basis
R2698 T2840 T2841 amod dependent,pathway
R2699 T3014 T3015 det the,inhibition
R2700 T3015 T3013 pobj inhibition,for
R2701 T2841 T2831 pobj pathway,via
R2702 T2842 T2844 nmod [,]
R2704 T2843 T2844 nummod 21,]
R2780 T3167 T3166 cc and,anti-CD3
R2781 T3168 T3166 conj anti-CD28,anti-CD3
R2782 T3169 T3165 pobj antibodies,by
R2784 T3170 T3164 prep in,activated
R2785 T3171 T3170 pobj vitro,in
R2786 T3172 T3133 punct .,investigated
R2788 T3173 T3175 nsubj We,studied
R2789 T3174 T3175 advmod also,studied
R2790 T3175 T3175 ROOT studied,studied
R2793 T3176 T3177 det the,effects
R2795 T3177 T3175 dobj effects,studied
R2796 T3178 T3177 prep of,effects
R2798 T3179 T3181 amod inhaled,therapy
R2799 T3180 T3181 compound fluticasone,therapy
R2800 T3181 T3178 pobj therapy,of
R2802 T3182 T3181 prep on,therapy
R2803 T3183 T3185 amod GATA-3,localization
R2804 T3184 T3185 amod subcellular,localization
R2806 T3185 T3182 pobj localization,on
R2807 T3186 T3185 prep in,localization
R2808 T3187 T3190 amod peripheral,cells
R2810 T3188 T3189 compound blood,mononuclear
R2811 T3189 T3190 compound mononuclear,cells
R2812 T3190 T3186 pobj cells,in
R2814 T3191 T3192 punct (,PBMCs
R2815 T3192 T3190 appos PBMCs,cells
R2816 T3193 T3192 punct ),PBMCs
R2818 T3194 T3192 prep from,PBMCs
R2819 T3195 T3194 pobj patients,from
R2820 T3196 T3192 prep with,PBMCs
R2822 T3197 T3196 pobj asthma,with
R2823 T3198 T3175 punct .,studied
R2835 T3083 T3085 nummod -13,activity
R2836 T3084 T3085 compound promoter,activity
R2837 T3085 T3079 conj activity,reduced
R2838 T3086 T3085 prep in,activity
R2839 T3087 T3091 amod human,cells
R2840 T3088 T3091 compound CD4,cells
R2841 T3089 T3091 nummod +,cells
R2842 T3090 T3091 compound T,cells
R2843 T3091 T3086 pobj cells,in
R2844 T3092 T3076 punct .,shown
R2845 T3093 T3094 det The,authors
R2846 T3094 T3095 nsubj authors,postulated
R2847 T3095 T3095 ROOT postulated,postulated
R2848 T3096 T3102 mark that,alter
R2881 T3129 T3128 pobj transcription,for
R2882 T3130 T3095 punct .,postulated
R2883 T3131 T3133 nsubj We,investigated
R2884 T3132 T3133 advmod therefore,investigated
R2885 T3133 T3133 ROOT investigated,investigated
R2886 T3134 T3135 det the,effects
R3292 T3810 T3815 npadvmod Participants,studied
R3293 T3811 T3810 cc and,Participants
R3294 T3812 T3813 compound Study,Design
R3295 T3813 T3810 conj Design,Participants
R3296 T3814 T3815 nsubj We,studied
R3297 T3815 T3815 ROOT studied,studied
R3298 T3816 T3815 dobj patients,studied
R3299 T3817 T3816 prep with,patients
R3300 T3818 T3819 amod mild,asthma
R3301 T3819 T3817 pobj asthma,with
R3302 T3820 T3823 nsubjpass who,treated
R3303 T3821 T3823 auxpass were,treated
R3304 T3822 T3823 neg not,treated
R3305 T3823 T3816 relcl treated,patients
R3306 T3824 T3823 prep with,treated
R3307 T3825 T3826 amod inhaled,corticosteroids
R3308 T3826 T3824 pobj corticosteroids,with
R3309 T3827 T3830 nsubjpass who,included
R3310 T3828 T3830 aux had,included
R3311 T3829 T3830 auxpass been,included
R3312 T3830 T3826 relcl included,corticosteroids
R3313 T3831 T3830 prep in,included
R3314 T3832 T3840 det a,study
R3315 T3833 T3834 advmod previously,reported
R3316 T3834 T3835 amod reported,double-blind
R3317 T3835 T3840 amod double-blind,study
R3318 T3836 T3840 punct ",",study
R3319 T3837 T3840 amod placebo-controlled,study
R3320 T3838 T3840 punct ",",study
R3321 T3839 T3840 amod crossover,study
R3322 T3840 T3831 pobj study,in
R3323 T3841 T3840 prep with,study
R3324 T3842 T3843 compound FP,[
R3325 T3843 T3841 pobj [,with
R3326 T3844 T3845 nummod 34,]
R3327 T3845 T3843 appos ],[
R3328 T3846 T3815 punct .,studied
R3329 T3847 T3848 nummod Seven,patients
R3330 T3848 T3852 nsubj patients,entered
R3331 T3849 T3848 prep with,patients
R3332 T3850 T3851 amod mild,asthma
R3333 T3851 T3849 pobj asthma,with
R3334 T3852 T3852 ROOT entered,entered
R3335 T3853 T3854 det the,study
R3336 T3854 T3852 dobj study,entered
R3337 T3855 T3852 cc and,entered
R3338 T3856 T3857 auxpass were,randomized
R3339 T3857 T3852 conj randomized,entered
R3340 T3858 T3859 aux to,receive
R3341 T3859 T3857 xcomp receive,randomized
R3342 T3860 T3862 det a,inhalation
R3343 T3861 T3862 amod single,inhalation
R3344 T3862 T3859 dobj inhalation,receive
R3345 T3863 T3862 prep of,inhalation
R3346 T3864 T3863 pobj FP,of
R3347 T3865 T3864 punct (,FP
R3348 T3866 T3864 nummod 100,FP
R3349 T3867 T3864 cc and,FP
R3350 T3868 T3869 nummod 500,µg
R3351 T3869 T3864 conj µg,FP
R3352 T3870 T3869 punct ),µg
R3353 T3871 T3869 cc or,µg
R3354 T3872 T3875 det a,control
R3355 T3873 T3875 amod matched,control
R3356 T3874 T3875 compound placebo,control
R3357 T3875 T3869 conj control,µg
R3358 T3876 T3859 prep via,receive
R3359 T3877 T3879 det a,chamber
R3360 T3878 T3879 compound spacer,chamber
R3361 T3879 T3876 pobj chamber,via
R3362 T3880 T3857 punct ",",randomized
R3363 T3881 T3857 cc and,randomized
R3364 T3882 T3884 det the,treatment
R3365 T3883 T3884 amod other,treatment
R3366 T3884 T3886 nsubjpass treatment,given
R3367 T3885 T3886 auxpass was,given
R3368 T3886 T3857 conj given,randomized
R3369 T3887 T3898 mark after,taken
R3370 T3888 T3890 det a,period
R3371 T3889 T3890 amod wash-out,period
R3372 T3890 T3898 nsubjpass period,taken
R3373 T3891 T3890 prep of,period
R3374 T3892 T3893 advmod at,least
R3375 T3893 T3894 advmod least,6
R3376 T3894 T3895 nummod 6,d.
R3377 T3895 T3896 compound d.,Blood
R3378 T3896 T3891 pobj Blood,of
R3389 T3907 T3898 conj h,taken
R3390 T3908 T3907 prep after,h
R3391 T3909 T3910 compound drug,administration
R3392 T3910 T3908 pobj administration,after
R3393 T3911 T3852 punct .,entered
R3394 T3912 T3913 det All,patients
R3395 T3913 T3914 nsubj patients,gave
R3396 T3914 T3914 ROOT gave,gave
R3397 T3915 T3916 amod informed,consent
R3398 T3916 T3914 dobj consent,gave
R3399 T3917 T3916 cc and,consent
R3400 T3918 T3919 det the,study
R3401 T3919 T3921 nsubjpass study,approved
R3402 T3920 T3921 auxpass was,approved
R3403 T3921 T3914 conj approved,gave
R3404 T3922 T3921 agent by,approved
R3405 T3923 T3925 det the,Committee
R3406 T3924 T3925 compound Ethics,Committee
R3407 T3925 T3922 pobj Committee,by
R3408 T3926 T3925 prep of,Committee
R3409 T3927 T3929 det the,Brompton
R3410 T3928 T3929 compound Royal,Brompton
R3411 T3929 T3926 pobj Brompton,of
R3412 T3930 T3929 cc and,Brompton
R3413 T3931 T3934 compound Harefield,Trust
R3414 T3932 T3934 compound Hospitals,Trust
R3415 T3933 T3934 compound NHS,Trust
R3416 T3934 T3929 conj Trust,Brompton
R3417 T3935 T3921 punct .,approved
R3418 T3936 T3938 det The,study
R3419 T3937 T3938 amod clinical,study
R3420 T3938 T3940 nsubjpass study,conducted
R3421 T3939 T3940 auxpass was,conducted
R3422 T3940 T3940 ROOT conducted,conducted
R3423 T3941 T3940 prep before,conducted
R3424 T3942 T3943 det the,requirement
R3425 T3943 T3941 pobj requirement,before
R3426 T3944 T3943 prep for,requirement
R3427 T3945 T3947 compound Clinical,Registration
R3428 T3946 T3947 compound Trial,Registration
R3429 T3947 T3944 pobj Registration,for
R3430 T3948 T3940 punct .,conducted
R3577 T4142 T4142 ROOT Antibodies,Antibodies
R3578 T4143 T4142 cc and,Antibodies
R3579 T4144 T4142 conj Reagents,Antibodies
R3580 T4145 T4147 det The,antibodies
R3581 T4146 T4147 amod monoclonal,antibodies
R3582 T4147 T4159 nsubjpass antibodies,purchased
R3583 T4148 T4147 prep against,antibodies
R3584 T4149 T4150 compound human,CD3
R3585 T4150 T4148 pobj CD3,against
R3586 T4151 T4150 punct ",",CD3
R3587 T4152 T4150 conj CD28,CD3
R3588 T4153 T4152 punct ",",CD28
R3589 T4154 T4152 conj GR,CD28
R3590 T4155 T4154 punct ",",GR
R3591 T4156 T4154 cc and,GR
R3592 T4157 T4154 conj importin-α,GR
R3593 T4158 T4159 auxpass were,purchased
R3594 T4159 T4159 ROOT purchased,purchased
R3595 T4160 T4159 prep from,purchased
R3596 T4161 T4162 compound BD,Biosciences
R3597 T4162 T4160 pobj Biosciences,from
R3598 T4163 T4162 punct (,Biosciences
R3599 T4164 T4162 npadvmod Oxford,Biosciences
R3600 T4165 T4164 punct ",",Oxford
R3601 T4166 T4167 compound United,Kingdom
R3602 T4167 T4164 appos Kingdom,Oxford
R3604 T4169 T4159 punct .,purchased
R3605 T4170 T4171 compound Rabbit,antibodies
R3606 T4171 T4186 nsubjpass antibodies,obtained
R3607 T4172 T4171 prep against,antibodies
R3608 T4173 T4174 compound human,GATA-3
R3609 T4174 T4172 pobj GATA-3,against
R3610 T4175 T4174 punct (,GATA-3
R3611 T4176 T4174 appos H-48,GATA-3
R3702 T4267 T4264 pobj Laboratories,from
R3703 T4268 T4267 punct (,Laboratories
R3704 T4269 T4267 npadvmod Oxford,Laboratories
R3705 T4270 T4269 punct ",",Oxford
R3706 T4271 T4269 appos UK,Oxford
R3707 T4272 T4269 punct ),Oxford
R3708 T4273 T4274 auxpass was,used
R3709 T4274 T4274 ROOT used,used
R3710 T4275 T4274 prep for,used
R3711 T4276 T4278 amod Western,analysis
R3712 T4277 T4278 compound blot,analysis
R3713 T4278 T4275 pobj analysis,for
R3714 T4279 T4274 punct .,used
R3715 T4280 T4282 det All,reagents
R3716 T4281 T4282 amod other,reagents
R3727 T4292 T4284 punct .,purchased
R3841 T4470 T4471 compound Cell,Culture
R3842 T4471 T4474 nsubj Culture,Isolation
R3843 T4472 T4471 cc and,Culture
R3844 T4473 T4471 conj PBMC,Culture
R3845 T4474 T4498 nsubjpass Isolation,cultured
R3846 T4475 T4479 det A,line
R3847 T4476 T4478 amod human,cell
R3848 T4477 T4478 compound T,cell
R3849 T4478 T4479 compound cell,line
R3850 T4479 T4474 dobj line,Isolation
R3851 T4480 T4484 punct (,purchased
R3852 T4481 T4484 nsubjpass HuT-78,purchased
R3853 T4482 T4481 punct ),HuT-78
R3854 T4483 T4484 auxpass was,purchased
R3855 T4484 T4474 relcl purchased,Isolation
R3856 T4485 T4484 prep from,purchased
R3857 T4486 T4488 compound ECACC,Collection
R3858 T4487 T4488 compound European,Collection
R3859 T4488 T4485 pobj Collection,from
R3860 T4489 T4488 prep of,Collection
R3861 T4490 T4491 compound Cell,Culture
R3862 T4491 T4489 pobj Culture,of
R3863 T4492 T4488 punct (,Collection
R3864 T4493 T4488 appos Wiltshire,Collection
R3865 T4494 T4493 punct ",",Wiltshire
R3866 T4495 T4493 appos UK,Wiltshire
R3867 T4496 T4493 punct ),Wiltshire
R3868 T4497 T4498 auxpass were,cultured
R3869 T4498 T4498 ROOT cultured,cultured
R3870 T4499 T4501 mark as,described
R3871 T4500 T4501 advmod previously,described
R3872 T4501 T4498 advcl described,cultured
R3873 T4502 T4504 nmod [,]
R3874 T4503 T4504 nummod 12,]
R3875 T4504 T4501 dobj ],described
R3876 T4505 T4498 punct .,cultured
R3877 T4506 T4508 nsubjpass PBMCs,isolated
R3878 T4507 T4508 auxpass were,isolated
R3879 T4508 T4529 ccomp isolated,described
R3880 T4509 T4508 agent by,isolated
R3881 T4510 T4511 compound density,centrifugation
R3882 T4511 T4509 pobj centrifugation,by
R3883 T4512 T4511 prep over,centrifugation
R3884 T4513 T4512 pobj Ficoll-Hypaque,over
R3885 T4514 T4515 punct (,density
R3886 T4515 T4513 appos density,Ficoll-Hypaque
R3887 T4516 T4515 punct ",",density
R3888 T4517 T4518 nummod 1.077,g/ml
R3889 T4518 T4515 appos g/ml,density
R3890 T4519 T4529 punct ;,described
R3891 T4520 T4521 compound Amersham,Biosciences
R3892 T4521 T4529 nsubj Biosciences,described
R3893 T4522 T4521 punct ",",Biosciences
R3894 T4523 T4521 conj Amersham,Biosciences
R3895 T4524 T4523 punct ",",Amersham
R3896 T4525 T4523 conj UK,Amersham
R3897 T4526 T4521 punct ),Biosciences
R3898 T4527 T4529 mark as,described
R3899 T4528 T4529 advmod previously,described
R3900 T4529 T4529 ROOT described,described
R3901 T4530 T4532 nmod [,]
R3902 T4531 T4532 nummod 34,]
R3903 T4532 T4529 dobj ],described
R3904 T4533 T4529 punct .,described
R3905 T4534 T4536 nsubjpass Cells,stimulated
R3906 T4535 T4536 auxpass were,stimulated
R3907 T4536 T4536 ROOT stimulated,stimulated
R3908 T4537 T4536 prep with,stimulated
R3909 T4538 T4540 amod anti-CD3,CD28
R3910 T4539 T4540 compound /,CD28
R3911 T4540 T4537 pobj CD28,with
R3912 T4541 T4540 punct (,CD28
R3913 T4542 T4543 nummod 1,µg
R3914 T4543 T4545 nmod µg,ml
R3915 T4544 T4545 compound /,ml
R3916 T4545 T4540 appos ml,CD28
R3917 T4546 T4545 npadvmod each,ml
R3918 T4547 T4540 punct ),CD28
R3919 T4548 T4536 prep for,stimulated
R3920 T4549 T4550 nummod 1,h
R3921 T4550 T4548 pobj h,for
R3922 T4551 T4550 prep at,h
R3923 T4552 T4553 nummod 37,°
R3924 T4553 T4551 pobj °,at
R3925 T4554 T4550 npadvmod C,h
R3926 T4555 T4556 aux to,stimulate
R3927 T4556 T4536 advcl stimulate,stimulated
R3928 T4557 T4559 amod Th2,release
R3929 T4558 T4559 compound cytokine,release
R3930 T4559 T4556 dobj release,stimulate
R3931 T4560 T4559 prep in,release
R3932 T4561 T4562 det the,presence
R3933 T4562 T4560 pobj presence,in
R3934 T4563 T4562 cc or,presence
R3935 T4564 T4562 conj absence,presence
R3936 T4565 T4562 prep of,presence
R3937 T4566 T4565 pobj FP,of
R3938 T4567 T4569 punct (,−
R3939 T4568 T4569 nummod 10,−
R3940 T4569 T4566 appos −,FP
R3941 T4570 T4572 quantmod 12,10
R3942 T4571 T4572 quantmod to,10
R3943 T4572 T4574 nummod 10,8M
R3944 T4573 T4574 nummod −,8M
R3945 T4574 T4569 npadvmod 8M,−
R3946 T4575 T4569 punct ),−
R3947 T4576 T4536 punct .,stimulated
R3948 T4577 T4579 nsubjpass Cytospins,prepared
R3949 T4578 T4579 auxpass were,prepared
R3950 T4579 T4582 amod prepared,localization
R3951 T4580 T4579 cc and,prepared
R3952 T4581 T4579 conj GATA-3,prepared
R3953 T4582 T4582 ROOT localization,localization
R3954 T4583 T4582 acl determined,localization
R3955 T4584 T4583 agent by,determined
R3956 T4585 T4586 amod confocal,microscopy
R3957 T4586 T4584 pobj microscopy,by
R3958 T4587 T4589 mark as,described
R3959 T4588 T4589 advmod previously,described
R3960 T4589 T4582 advcl described,localization
R3961 T4590 T4592 nmod [,]
R3962 T4591 T4592 nummod 12,]
R3963 T4592 T4589 dobj ],described
R3964 T4593 T4582 punct .,localization
R4061 T4717 T4721 amod Reverse,RNA
R4062 T4718 T4721 compound Transcription,RNA
R4063 T4719 T4721 compound PCR,RNA
R4064 T4720 T4721 compound Total,RNA
R4065 T4721 T4723 nsubjpass RNA,extracted
R4066 T4722 T4723 auxpass was,extracted
R4067 T4723 T4723 ROOT extracted,extracted
R4068 T4724 T4723 advcl using,extracted
R4069 T4725 T4726 compound lysis,buffer
R4070 T4726 T4724 dobj buffer,using
R4071 T4727 T4726 punct (,buffer
R4072 T4728 T4729 compound RNeasy,kit
R4073 T4729 T4726 appos kit,buffer
R4074 T4730 T4726 punct ;,buffer
R4075 T4731 T4726 conj Qiagen,buffer
R4076 T4732 T4731 punct ",",Qiagen
R4077 T4733 T4731 conj Crawley,Qiagen
R4078 T4734 T4733 punct ",",Crawley
R4079 T4735 T4733 conj UK,Crawley
R4080 T4736 T4731 punct ),Qiagen
R4081 T4737 T4723 punct .,extracted
R4082 T4738 T4745 prep During,digested
R4083 T4739 T4740 compound RNA,purification
R4084 T4740 T4738 pobj purification,During
R4085 T4741 T4745 punct ",",digested
R4086 T4742 T4743 amod genomic,DNA
R4087 T4743 T4745 nsubjpass DNA,digested
R4088 T4744 T4745 auxpass was,digested
R4089 T4745 T4745 ROOT digested,digested
R4090 T4746 T4745 prep with,digested
R4091 T4747 T4748 compound RNase-free,DNase
R4092 T4748 T4746 pobj DNase,with
R4093 T4749 T4751 punct (,Biosciences
R4094 T4750 T4751 compound Amersham,Biosciences
R4095 T4751 T4748 appos Biosciences,DNase
R4096 T4752 T4751 punct ),Biosciences
R4097 T4753 T4745 punct .,digested
R4098 T4754 T4757 advmod Next,µg
R4099 T4755 T4757 punct ",",µg
R4100 T4756 T4757 nummod 0.5,µg
R4101 T4757 T4763 nsubjpass µg,transcribed
R4102 T4758 T4757 prep of,µg
R4103 T4759 T4760 amod total,RNA
R4104 T4760 T4758 pobj RNA,of
R4105 T4761 T4763 auxpass was,transcribed
R4106 T4762 T4763 advmod reversed,transcribed
R4107 T4763 T4763 ROOT transcribed,transcribed
R4108 T4764 T4763 advcl using,transcribed
R4109 T4765 T4768 det the,virus
R4110 T4766 T4767 amod avian,myeloblastosis
R4111 T4767 T4768 compound myeloblastosis,virus
R4134 T4790 T4793 nsubj Primers,were
R4135 T4791 T4790 prep for,Primers
R4136 T4792 T4791 pobj IL-4,for
R4137 T4793 T4793 ROOT were,were
R4138 T4794 T4793 prep from,were
R4139 T4795 T4794 pobj Sigma-Genosys,from
R4140 T4796 T4795 punct (,Sigma-Genosys
R4141 T4797 T4795 appos Cambridge,Sigma-Genosys
R4142 T4798 T4797 punct ",",Cambridge
R4143 T4799 T4797 appos UK,Cambridge
R4144 T4800 T4797 punct ),Cambridge
R4145 T4801 T4793 punct .,were
R4146 T4802 T4806 nsubj Sequences,are
R4147 T4803 T4802 prep of,Sequences
R4148 T4804 T4803 pobj GADPH,of
R4149 T4805 T4802 acl used,Sequences
R4150 T4806 T4806 ROOT are,are
R4151 T4807 T4808 mark as,follows
R4152 T4808 T4806 advcl follows,are
R4153 T4809 T4806 punct :,are
R4154 T4810 T4816 advmod forward,reverse
R4155 T4811 T4814 nummod 5,CCACCCATGGCAAATTCCATGGC
R4156 T4812 T4814 punct ′,CCACCCATGGCAAATTCCATGGC
R4157 T4813 T4814 punct -,CCACCCATGGCAAATTCCATGGC
R4158 T4814 T4816 npadvmod CCACCCATGGCAAATTCCATGGC,reverse
R4159 T4815 T4816 punct ",",reverse
R4160 T4816 T4820 dep reverse,TCTAGACGGCAGGTCAGGTCCAC
R4161 T4817 T4816 dobj 3,reverse
R4162 T4818 T4820 punct ′,TCTAGACGGCAGGTCAGGTCCAC
R4163 T4819 T4820 punct -,TCTAGACGGCAGGTCAGGTCCAC
R4164 T4820 T4820 ROOT TCTAGACGGCAGGTCAGGTCCAC,TCTAGACGGCAGGTCAGGTCCAC
R4165 T4821 T4820 punct .,TCTAGACGGCAGGTCAGGTCCAC
R4322 T5013 T5014 compound Cell,Fractionation
R4323 T5014 T5027 nsubjpass Fractionation,prepared
R4324 T5015 T5014 punct ",",Fractionation
R4325 T5016 T5014 conj Immunoprecipitation,Fractionation
R4326 T5017 T5016 punct ",",Immunoprecipitation
R4327 T5018 T5016 cc and,Immunoprecipitation
R4328 T5019 T5022 amod Western,Nuclear
R4329 T5020 T5022 compound Blot,Nuclear
R4330 T5021 T5022 compound Analysis,Nuclear
R4331 T5022 T5016 conj Nuclear,Immunoprecipitation
R4332 T5023 T5022 cc and,Nuclear
R4333 T5024 T5022 conj cytoplasmic,Nuclear
R4334 T5025 T5014 appos fractions,Fractionation
R4335 T5026 T5027 auxpass were,prepared
R4336 T5027 T5027 ROOT prepared,prepared
R4337 T5028 T5030 mark as,described
R4338 T5029 T5030 advmod previously,described
R4339 T5030 T5027 advcl described,prepared
R4340 T5031 T5033 nmod [,]
R4341 T5032 T5033 nummod 35,]
R4342 T5033 T5030 dobj ],described
R4343 T5034 T5027 punct .,prepared
R4344 T5035 T5037 amod Whole,lysates
R4345 T5036 T5037 compound cell,lysates
R4346 T5037 T5039 nsubjpass lysates,prepared
R4347 T5038 T5039 auxpass were,prepared
R4348 T5039 T5039 ROOT prepared,prepared
R4349 T5040 T5039 prep in,prepared
R4350 T5041 T5043 compound NP-40,buffer
R4351 T5042 T5043 compound lysis,buffer
R4352 T5043 T5040 pobj buffer,in
R4353 T5044 T5048 punct (,P-40
R4354 T5045 T5046 nummod 0.5,%
R4355 T5046 T5048 compound %,P-40
R4356 T5047 T5048 compound Nonidet,P-40
R4357 T5048 T5043 appos P-40,buffer
R4358 T5049 T5048 punct ",",P-40
R4359 T5050 T5054 nummod 20,pH
R4360 T5051 T5054 compound mM,pH
R4361 T5052 T5054 compound Tris-HCl,pH
R4415 T5106 T5104 conj importin-α,GATA-3
R4438 T5129 T5128 punct ",",Placid
R4439 T5130 T5131 compound New,York
R4440 T5131 T5128 conj York,Placid
R4441 T5132 T5131 punct ",",York
R4442 T5133 T5131 conj USA,York
R4443 T5134 T5125 punct ),Biotechnology
R4444 T5135 T5096 punct .,immunoprecipitated
R4445 T5136 T5138 amod Western,analysis
R4446 T5137 T5138 compound blot,analysis
R4447 T5138 T5140 nsubjpass analysis,performed
R4448 T5139 T5140 auxpass was,performed
R4449 T5140 T5140 ROOT performed,performed
R4450 T5141 T5140 advcl using,performed
R4451 T5142 T5141 dobj anti-GATA-3,using
R4452 T5143 T5142 punct ",",anti-GATA-3
R4453 T5144 T5142 conj anti-importin-α,anti-GATA-3
R4454 T5145 T5144 punct ",",anti-importin-α
R4455 T5146 T5144 conj anti-GR,anti-importin-α
R4456 T5147 T5146 punct ",",anti-GR
R4457 T5148 T5150 amod anti-p-p38,kinase
R4458 T5149 T5150 compound MAP,kinase
R4459 T5150 T5146 conj kinase,anti-GR
R4460 T5151 T5150 punct ",",kinase
R4461 T5152 T5150 conj anti-p-ATF-2,kinase
R4462 T5153 T5152 punct ",",anti-p-ATF-2
R4463 T5154 T5152 cc and,anti-p-ATF-2
R4464 T5155 T5152 conj anti-p-serine,anti-p-ATF-2
R4465 T5156 T5140 punct .,performed
R4466 T5157 T5158 amod Immunoreactive,proteins
R4467 T5158 T5160 nsubjpass proteins,detected
R4468 T5159 T5160 auxpass were,detected
R4469 T5160 T5160 ROOT detected,detected
R4470 T5161 T5160 advcl using,detected
R4471 T5162 T5166 det an,kit
R4472 T5163 T5166 amod enhanced,kit
R4473 T5164 T5165 compound chemiluminescence,ECL
R4474 T5165 T5166 compound ECL,kit
R4475 T5166 T5161 dobj kit,using
R4476 T5167 T5166 punct (,kit
R4477 T5168 T5169 compound Amersham,Biosciences
R4478 T5169 T5166 appos Biosciences,kit
R4479 T5170 T5166 punct ),kit
R4480 T5171 T5160 punct .,detected
R4593 T5318 T5321 compound Chromatin,immunoprecipitation
R4594 T5319 T5321 compound Immunoprecipitation,immunoprecipitation
R4595 T5320 T5321 compound Chromatin,immunoprecipitation
R4596 T5321 T5326 nsubjpass immunoprecipitation,performed
R4597 T5322 T5323 punct (,IP
R4598 T5323 T5321 appos IP,immunoprecipitation
R4599 T5324 T5321 punct ),immunoprecipitation
R4600 T5325 T5326 auxpass was,performed
R4601 T5326 T5326 ROOT performed,performed
R4602 T5327 T5329 mark as,described
R4603 T5328 T5329 advmod previously,described
R4604 T5329 T5326 advcl described,performed
R4605 T5330 T5332 nmod [,]
R4606 T5331 T5332 nummod 12,]
R4607 T5332 T5329 dobj ],described
R4608 T5333 T5329 prep in,described
R4609 T5334 T5335 compound HuT-78,T-cells
R4610 T5335 T5333 pobj T-cells,in
R4611 T5336 T5335 prep with,T-cells
R4612 T5337 T5338 nummod 2,µg
R4613 T5338 T5336 pobj µg,with
R4614 T5339 T5338 prep of,µg
R4615 T5340 T5339 pobj anti-GATA-3,of
R4616 T5341 T5344 punct (,Biotechnology
R4617 T5342 T5344 compound Santa,Biotechnology
R4618 T5343 T5344 compound Cruz,Biotechnology
R4619 T5344 T5340 appos Biotechnology,anti-GATA-3
R4620 T5345 T5344 punct ),Biotechnology
R4621 T5346 T5344 punct ",",Biotechnology
R4622 T5347 T5344 cc or,Biotechnology
R4623 T5348 T5350 amod isotypic,G
R4624 T5349 T5350 compound immunoglobulin,G
R4625 T5350 T5344 conj G,Biotechnology
R4626 T5351 T5338 prep as,µg
R4627 T5352 T5354 det a,control
R4628 T5353 T5354 amod non-specific,control
R4629 T5354 T5351 pobj control,as
R4630 T5355 T5358 punct (,Biotechnology
R4631 T5356 T5357 compound Santa,Cruz
R4632 T5357 T5358 compound Cruz,Biotechnology
R4633 T5358 T5354 appos Biotechnology,control
R4634 T5359 T5354 punct ),control
R4635 T5360 T5329 advmod overnight,described
R4636 T5361 T5329 prep at,described
R4637 T5362 T5363 nummod 4,°
R4638 T5363 T5366 nummod °,sequences
R4639 T5364 T5365 compound C.,Promoter
R4640 T5365 T5366 compound Promoter,sequences
R4641 T5366 T5368 nsubjpass sequences,detected
R4642 T5367 T5368 auxpass were,detected
R4643 T5368 T5326 conj detected,performed
R4644 T5369 T5368 prep with,detected
R4645 T5370 T5371 compound PCR,primers
R4646 T5371 T5369 pobj primers,with
R4647 T5372 T5371 prep for,primers
R4648 T5373 T5375 det the,promoter
R4649 T5374 T5375 compound IL-5,promoter
R4650 T5375 T5372 pobj promoter,for
R4651 T5376 T5375 punct (,promoter
R4652 T5377 T5388 advmod −,′
R4653 T5378 T5388 meta 445,′
R4654 T5379 T5378 prep to,445
R4655 T5380 T5379 pobj +4,to
R4656 T5381 T5378 punct ),445
R4657 T5382 T5388 punct :,′
R4658 T5383 T5388 advmod forward,′
R4659 T5384 T5388 nummod 5,′
R4660 T5385 T5387 punct ′,TTAATCTAGCCACAGTCATAG-3
R4661 T5386 T5387 punct -,TTAATCTAGCCACAGTCATAG-3
R4662 T5387 T5388 compound TTAATCTAGCCACAGTCATAG-3,′
R4663 T5388 T5375 appos ′,promoter
R4664 T5389 T5388 cc and,′
R4665 T5390 T5388 conj reverse,′
R4666 T5391 T5388 punct :,′
R4667 T5392 T5395 nummod 5,TCATGGCTCTGAAACGTTCTG-3
R4687 T5412 T5410 appos UK,Ashford
R4688 T5413 T5408 punct ),Hybaid
R4689 T5414 T5408 prep with,Hybaid
R4690 T5415 T5416 compound cycling,parameters
R4691 T5416 T5414 pobj parameters,with
R4692 T5417 T5416 prep of,parameters
R4693 T5418 T5420 nummod 72,C
R4694 T5419 T5420 compound °,C
R4695 T5420 T5417 pobj C,of
R4696 T5421 T5401 prep for,using
R4697 T5422 T5423 nummod 10,min
R4698 T5423 T5421 pobj min,for
R4699 T5424 T5423 punct ",",min
R4700 T5425 T5426 nummod 35,cycles
R4701 T5426 T5423 appos cycles,min
R4702 T5427 T5401 prep at,using
R4703 T5428 T5429 nummod 94,°
R4704 T5429 T5427 pobj °,at
R4705 T5430 T5401 dobj C,using
R4706 T5431 T5401 prep for,using
R4707 T5432 T5433 nummod 45,s
R4708 T5433 T5431 pobj s,for
R4709 T5434 T5433 punct ",",s
R4710 T5435 T5437 nummod 52,C
R4711 T5436 T5437 compound °,C
R4712 T5437 T5433 appos C,s
R4713 T5438 T5401 prep for,using
R4714 T5439 T5438 pobj 45,for
R4715 T5440 T5401 dobj s,using
R4716 T5441 T5440 punct ",",s
R4717 T5442 T5444 nummod 72,C
R4718 T5443 T5444 compound °,C
R4719 T5444 T5440 appos C,s
R4720 T5445 T5401 prep for,using
R4721 T5446 T5447 nummod 45,s.
R4722 T5447 T5445 pobj s.,for
R4970 T5754 T5754 ROOT GR-GATA-3,GR-GATA-3
R4971 T5755 T5778 prep In,separated
R4972 T5756 T5758 compound Vitro,Assay
R4973 T5757 T5758 compound Competition,Assay
R4976 T5760 T5759 pobj Importin-α,for
R4977 T5761 T5760 punct (,Importin-α
R4978 T5762 T5763 compound Far-Western,ELISA
R4979 T5763 T5760 appos ELISA,Importin-α
R4980 T5764 T5760 punct ),Importin-α
R4981 T5765 T5766 compound Immunoprecipitated,importin-α
R4982 T5766 T5778 nsubjpass importin-α,separated
R4983 T5767 T5772 punct (,Biotechnology
R4984 T5768 T5772 npadvmod anti-importin-α,Biotechnology
R4985 T5769 T5772 punct ",",Biotechnology
R4986 T5770 T5771 compound Santa,Cruz
R4987 T5771 T5772 compound Cruz,Biotechnology
R4988 T5772 T5766 appos Biotechnology,importin-α
R4989 T5773 T5772 punct ),Biotechnology
R4990 T5774 T5772 prep from,Biotechnology
R4991 T5775 T5776 amod HuT-78,cells
R4992 T5776 T5774 pobj cells,from
R4993 T5777 T5778 auxpass was,separated
R4994 T5778 T5778 ROOT separated,separated
R4995 T5779 T5778 agent by,separated
R4996 T5780 T5779 pobj SDS-PAGE,by
R4997 T5781 T5778 cc and,separated
R4998 T5782 T5778 conj purified,separated
R4999 T5783 T5782 prep from,purified
R5000 T5784 T5786 det the,gel
R5001 T5785 T5786 amod excised,gel
R5002 T5786 T5783 pobj gel,from
R5003 T5787 T5786 prep by,gel
R5004 T5788 T5789 compound electroelution,[
R5005 T5789 T5787 pobj [,by
R5006 T5790 T5791 nummod 36,]
R5007 T5791 T5789 appos ],[
R5008 T5792 T5778 punct .,separated
R5009 T5793 T5796 advmod Similarly,was
R5010 T5794 T5796 punct ",",was
R5011 T5795 T5796 nsubj GATA-3,was
R5012 T5796 T5796 ROOT was,was
R5013 T5797 T5796 acomp isolated,was
R5014 T5798 T5797 prep from,isolated
R5015 T5799 T5801 amod nonstimulated,cells
R5016 T5800 T5801 amod HuT-78,cells
R5017 T5801 T5798 pobj cells,from
R5018 T5802 T5801 cc or,cells
R5019 T5803 T5801 conj cells,cells
R5020 T5804 T5796 conj stimulated,was
R5021 T5805 T5804 prep for,stimulated
R5022 T5806 T5807 nummod 30,min
R5023 T5807 T5805 pobj min,for
R5024 T5808 T5807 prep with,min
R5025 T5809 T5810 compound anti-CD3,/
R5026 T5810 T5808 pobj /,with
R5027 T5811 T5810 nummod CD28,/
R5028 T5812 T5810 cc and,/
R5029 T5813 T5814 nsubj GR,was
R5030 T5814 T5796 conj was,was
R5031 T5815 T5814 acomp isolated,was
R5032 T5816 T5815 prep from,isolated
R5033 T5817 T5816 pobj FP,from
R5034 T5818 T5817 punct (,FP
R5035 T5819 T5820 nummod 10,−
R5036 T5820 T5817 appos −,FP
R5037 T5821 T5822 nummod 8,M
R5038 T5822 T5817 conj M,FP
R5039 T5823 T5822 punct ",",M
R5040 T5824 T5825 nummod 30,min
R5041 T5825 T5822 appos min,M
R5042 T5826 T5822 punct ),M
R5043 T5827 T5814 conj stimulated,was
R5044 T5828 T5829 amod HuT-78,cells
R5045 T5829 T5827 dobj cells,stimulated
R5046 T5830 T5814 punct .,was
R5047 T5831 T5832 det These,proteins
R5048 T5832 T5835 nsubjpass proteins,refolded
R5049 T5833 T5835 auxpass were,refolded
R5050 T5834 T5835 advmod subsequently,refolded
R5051 T5835 T5835 ROOT refolded,refolded
R5052 T5836 T5835 prep in,refolded
R5053 T5837 T5838 amod glycine,solution
R5054 T5838 T5836 pobj solution,in
R5055 T5839 T5835 punct .,refolded
R5056 T5840 T5841 nummod 100,µl
R5057 T5841 T5852 nsubjpass µl,added
R5058 T5842 T5841 prep of,µl
R5059 T5843 T5844 amod importin-α,solution
R5060 T5844 T5842 pobj solution,of
R5061 T5845 T5844 punct (,solution
R5062 T5846 T5847 nummod 100,ng/ml
R5063 T5847 T5844 appos ng/ml,solution
R5064 T5848 T5847 prep in,ng/ml
R5065 T5849 T5848 pobj TBS,in
R5066 T5850 T5844 punct ),solution
R5067 T5851 T5852 auxpass was,added
R5068 T5852 T5852 ROOT added,added
R5069 T5853 T5852 prep to,added
R5071 T5855 T5854 dobj plates,96-well
R5072 T5856 T5855 acl coated,plates
R5073 T5857 T5856 prep with,coated
R5074 T5858 T5860 amod goat,antibody
R5075 T5859 T5860 amod anti-importin-α,antibody
R5085 T5869 T5870 nummod 100,ng/ml
R5086 T5870 T5867 appos ng/ml,GATA-3
R5087 T5871 T5870 prep in,ng/ml
R5088 T5872 T5871 pobj TBS,in
R5089 T5873 T5870 punct ),ng/ml
R5090 T5874 T5870 prep from,ng/ml
R5091 T5875 T5878 amod stimulated,cells
R5092 T5876 T5875 cc or,stimulated
R5093 T5877 T5875 conj unstimulated,stimulated
R5094 T5878 T5874 pobj cells,from
R5095 T5879 T5880 auxpass were,added
R5096 T5880 T5880 ROOT added,added
R5097 T5881 T5880 prep to,added
R5098 T5882 T5884 det the,wells
R5099 T5883 T5884 amod importin-α-coated,wells
R5100 T5884 T5881 pobj wells,to
R5101 T5885 T5880 punct .,added
R5102 T5886 T5901 nsubjpass GR,added
R5103 T5887 T5886 punct (,GR
R5104 T5888 T5891 nummod 10,ng/ml
R5105 T5889 T5888 cc or,10
R5106 T5890 T5888 conj 100,10
R5107 T5891 T5886 appos ng/ml,GR
R5108 T5892 T5891 prep in,ng/ml
R5109 T5893 T5892 pobj TBS,in
R5110 T5894 T5891 punct ),ng/ml
R5111 T5895 T5891 prep from,ng/ml
R5112 T5896 T5899 amod stimulated,cells
R5113 T5897 T5896 cc or,stimulated
R5114 T5898 T5896 conj unstimulated,stimulated
R5115 T5899 T5895 pobj cells,from
R5116 T5900 T5901 auxpass were,added
R5117 T5901 T5901 ROOT added,added
R5118 T5902 T5901 prep to,added
R5119 T5903 T5904 det some,wells
R5120 T5904 T5902 pobj wells,to
R5121 T5905 T5901 punct .,added
R5122 T5906 T5916 prep After,washed
R5123 T5907 T5911 det a,incubation
R5124 T5908 T5911 amod further,incubation
R5125 T5909 T5910 nummod 1,h
R5126 T5910 T5911 compound h,incubation
R5127 T5911 T5906 pobj incubation,After
R5128 T5912 T5916 punct ",",washed
R5129 T5913 T5914 det the,plate
R5130 T5914 T5916 nsubjpass plate,washed
R5131 T5915 T5916 auxpass was,washed
R5132 T5916 T5916 ROOT washed,washed
R5133 T5917 T5916 cc and,washed
R5134 T5918 T5916 conj incubated,washed
R5135 T5919 T5918 prep with,incubated
R5136 T5920 T5921 amod primary,antibodies
R5137 T5921 T5919 pobj antibodies,with
R5138 T5922 T5921 punct (,antibodies
R5139 T5923 T5924 det a,mixture
R5140 T5924 T5921 appos mixture,antibodies
R5141 T5925 T5924 prep of,mixture
R5142 T5926 T5927 compound rabbit,anti-GATA-3
R5143 T5927 T5925 pobj anti-GATA-3,of
R5144 T5928 T5927 cc and,anti-GATA-3
R5145 T5929 T5927 conj mouse,anti-GATA-3
R5146 T5930 T5927 conj anti-GR,anti-GATA-3
R5147 T5931 T5930 punct ",",anti-GR
R5148 T5932 T5934 compound Santa,Biotechnology
R5149 T5933 T5934 compound Cruz,Biotechnology
R5150 T5934 T5927 appos Biotechnology,anti-GATA-3
R5151 T5935 T5921 punct ),antibodies
R5152 T5936 T5918 prep for,incubated
R5153 T5937 T5938 nummod 1.5,h
R5154 T5938 T5936 pobj h,for
R5155 T5939 T5918 punct ",",incubated
R5156 T5940 T5918 cc and,incubated
R5157 T5941 T5942 advmod then,incubated
R5158 T5942 T5918 conj incubated,incubated
R5159 T5943 T5942 prep with,incubated
R5160 T5944 T5945 amod secondary,antibodies
R5161 T5945 T5943 pobj antibodies,with
R5162 T5946 T5916 punct .,washed
R5163 T5947 T5948 nummod FITC,swine
R5164 T5948 T5949 nsubj swine,anti-rabbit
R5165 T5949 T5959 nsubjpass anti-rabbit,used
R5166 T5950 T5949 dobj IgG,anti-rabbit
R5167 T5951 T5952 punct (,Dako
R5168 T5952 T5950 appos Dako,IgG
R5169 T5953 T5952 punct ",",Dako
R5170 T5954 T5952 npadvmod Cambridge,Dako
R5171 T5955 T5954 punct ",",Cambridge
R5172 T5956 T5954 appos UK,Cambridge
R5173 T5957 T5954 punct ),Cambridge
R5174 T5958 T5959 auxpass was,used
R5175 T5959 T5959 ROOT used,used
R5176 T5960 T5959 prep for,used
R5177 T5961 T5962 det the,detection
R5178 T5962 T5960 pobj detection,for
R5179 T5963 T5962 prep of,detection
R5207 T5991 T5993 nsubjpass levels,measured
R5208 T5992 T5993 auxpass were,measured
R5209 T5993 T5993 ROOT measured,measured
R5210 T5994 T5993 prep with,measured
R5211 T5995 T5998 det a,reader
R5212 T5996 T5998 amod fluorescent,reader
R5213 T5997 T5998 amod micro-plate,reader
R5214 T5998 T5994 pobj reader,with
R5215 T5999 T5998 punct (,reader
R5216 T6000 T5998 appos Bioline,reader
R5217 T6001 T6000 punct ",",Bioline
R5218 T6002 T6000 conj London,Bioline
R5219 T6003 T6002 punct ",",London
R5220 T6004 T6002 conj UK,London
R5221 T6005 T5998 punct ),reader
R5222 T6006 T5993 punct .,measured
R5304 T6161 T6163 compound NF-κB,NF-κB
R5305 T6162 T6163 compound Activation,NF-κB
R5306 T6163 T6170 nsubjpass NF-κB,determined
R5307 T6164 T6165 amod binding,activity
R5308 T6165 T6163 dobj activity,NF-κB
R5309 T6166 T6165 prep in,activity
R5310 T6167 T6168 amod nuclear,extracts
R5311 T6168 T6166 pobj extracts,in
R5312 T6169 T6170 auxpass was,determined
R5313 T6170 T6170 ROOT determined,determined
R5342 T6199 T6197 pobj plate,with
R5343 T6200 T6199 acl coated,plate
R5344 T6201 T6200 prep with,coated
R5345 T6202 T6204 det an,consensus
R5346 T6203 T6204 amod NF-κB,consensus
R5347 T6204 T6205 compound consensus,oligonucleotide
R5348 T6205 T6201 pobj oligonucleotide,with
R5349 T6206 T6196 punct .,incubated
R5350 T6207 T6209 nsubjpass Plates,washed
R5351 T6208 T6209 auxpass were,washed
R5352 T6209 T6209 ROOT washed,washed
R5353 T6210 T6209 prep before,washed
R5354 T6211 T6210 pobj addition,before
R5355 T6212 T6211 prep of,addition
R5356 T6213 T6215 det an,antibody
R5357 T6214 T6215 amod anti-p65,antibody
R5358 T6215 T6212 pobj antibody,of
R5359 T6216 T6209 punct .,washed
R5360 T6217 T6218 compound Antibody,binding
R5361 T6218 T6220 nsubjpass binding,detected
R5362 T6219 T6220 auxpass was,detected
R5363 T6220 T6220 ROOT detected,detected
R5364 T6221 T6220 prep with,detected
R5365 T6222 T6225 det a,antibody
R5366 T6223 T6225 amod secondary,antibody
R5367 T6224 T6225 amod HRP-conjugated,antibody
R5368 T6225 T6221 pobj antibody,with
R5369 T6226 T6220 cc and,detected
R5370 T6227 T6220 conj developed,detected
R5371 T6228 T6227 prep with,developed
R5372 T6229 T6230 compound TMB,substrate
R5373 T6230 T6228 pobj substrate,with
R5374 T6231 T6220 punct .,detected
R5375 T6232 T6233 det The,intensity
R5376 T6233 T6238 nsubjpass intensity,measured
R5377 T6234 T6233 prep of,intensity
R5378 T6235 T6236 det the,reaction
R5379 T6236 T6234 pobj reaction,of
R5380 T6237 T6238 auxpass was,measured
R5381 T6238 T6238 ROOT measured,measured
R5382 T6239 T6238 prep at,measured
R5383 T6240 T6241 nummod 450,nm
R5384 T6241 T6239 pobj nm,at
R5385 T6242 T6238 punct .,measured
R5594 T6486 T6488 compound Immunofluorescence,Immunofluorescence
R5595 T6487 T6488 compound Staining,Immunofluorescence
R5596 T6488 T6491 nsubjpass Immunofluorescence,performed
R5597 T6489 T6488 acl staining,Immunofluorescence
R5598 T6490 T6491 auxpass was,performed
R5599 T6491 T6491 ROOT performed,performed
R5600 T6492 T6494 mark as,described
R5601 T6493 T6494 advmod previously,described
R5602 T6494 T6491 advcl described,performed
R5603 T6495 T6497 nmod [,]
R5604 T6496 T6497 nummod 34,]
R5605 T6497 T6494 dobj ],described
R5606 T6498 T6491 punct .,performed
R5607 T6499 T6500 det All,staining
R5608 T6500 T6502 nsubjpass staining,performed
R5609 T6501 T6502 auxpass was,performed
R5610 T6502 T6502 ROOT performed,performed
R5611 T6503 T6502 prep at,performed
R5612 T6504 T6505 compound room,temperature
R5613 T6505 T6503 pobj temperature,at
R5614 T6506 T6503 cc and,at
R5615 T6507 T6503 conj under,at
R5616 T6508 T6507 pobj humidification,under
R5617 T6509 T6502 punct .,performed
R5618 T6510 T6512 nsubjpass Cells,collected
R5619 T6511 T6512 auxpass were,collected
R5620 T6512 T6512 ROOT collected,collected
R5621 T6513 T6512 cc and,collected
R5622 T6514 T6512 conj cytospins,collected
R5623 T6515 T6514 acl prepared,cytospins
R5624 T6516 T6515 prep in,prepared
R5625 T6517 T6518 det a,cytocentrifuge
R5626 T6518 T6516 pobj cytocentrifuge,in
R5627 T6519 T6521 punct (,II
R5628 T6520 T6521 compound Shandon,II
R5629 T6521 T6518 appos II,cytocentrifuge
R5630 T6522 T6521 punct ",",II
R5631 T6523 T6521 conj Shandon,II
R5632 T6524 T6523 punct ",",Shandon
R5633 T6525 T6523 conj Runcorn,Shandon
R5634 T6526 T6525 punct ",",Runcorn
R5635 T6527 T6525 conj UK,Runcorn
R5636 T6528 T6521 punct ),II
R5637 T6529 T6512 punct .,collected
R5638 T6530 T6532 nsubjpass Cells,permeabilized
R5639 T6531 T6532 auxpass were,permeabilized
R5640 T6532 T6532 ROOT permeabilized,permeabilized
R5641 T6533 T6532 punct ",",permeabilized
R5642 T6534 T6532 conj blocked,permeabilized
R5643 T6535 T6534 punct ",",blocked
R5644 T6536 T6532 cc and,permeabilized
R5645 T6537 T6538 advmod then,incubated
R5646 T6538 T6532 conj incubated,permeabilized
R5647 T6539 T6538 prep with,incubated
R5648 T6540 T6539 pobj GR,with
R5649 T6541 T6542 punct (,1
R5650 T6542 T6548 nummod 1,Biotechnology
R5651 T6543 T6548 nummod ∶,Biotechnology
R5652 T6544 T6545 nummod 50,E-20
R5653 T6545 T6548 compound E-20,Biotechnology
R5654 T6546 T6547 compound Santa,Cruz
R5655 T6547 T6548 compound Cruz,Biotechnology
R5656 T6548 T6540 appos Biotechnology,GR
R5657 T6549 T6538 punct ),incubated
R5658 T6550 T6538 cc or,incubated
R5659 T6551 T6538 conj anti-GATA-3,incubated
R5660 T6552 T6559 punct (,antibody
R5661 T6553 T6559 amod H-48,antibody
R5662 T6554 T6559 punct ;,antibody
R5663 T6555 T6556 compound Santa,Cruz
R5664 T6556 T6557 compound Cruz,Biotechnology
R5665 T6557 T6559 compound Biotechnology,antibody
R5666 T6558 T6557 punct ),Biotechnology
R5667 T6559 T6559 ROOT antibody,antibody
R5668 T6560 T6559 prep for,antibody
R5669 T6561 T6562 nummod 1,h
R5670 T6562 T6560 pobj h,for
R5671 T6563 T6562 prep at,h
R5672 T6564 T6565 compound room,temperature
R5673 T6565 T6563 pobj temperature,at
R5674 T6566 T6532 punct .,permeabilized
R5675 T6567 T6579 prep After,incubated
R5676 T6568 T6569 nummod three,washes
R5677 T6569 T6567 pobj washes,After
R5678 T6570 T6569 prep in,washes
R5679 T6571 T6572 amod phosphate-buffered,saline
R5680 T6572 T6570 pobj saline,in
R5681 T6573 T6574 punct (,PBS
R5682 T6574 T6569 appos PBS,washes
R5683 T6575 T6569 punct ),washes
R5684 T6576 T6579 punct ",",incubated
R5685 T6577 T6579 nsubjpass cells,incubated
R5686 T6578 T6579 auxpass were,incubated
R5687 T6579 T6579 ROOT incubated,incubated
R5688 T6580 T6579 prep with,incubated
R5689 T6581 T6582 amod tetrarhodamine,isothiocyanate
R5690 T6582 T6580 pobj isothiocyanate,with
R5691 T6583 T6586 amod conjugated,antibody
R5692 T6584 T6586 nmod goat,antibody
R5693 T6585 T6586 amod anti-rabbit,antibody
R5694 T6586 T6586 ROOT antibody,antibody
R5695 T6587 T6588 punct (,Dako
R5696 T6588 T6586 appos Dako,antibody
R5697 T6589 T6588 punct ),Dako
R5698 T6590 T6586 punct .,antibody
R5699 T6591 T6593 nsubjpass Cytospins,counterstained
R5700 T6592 T6593 auxpass were,counterstained
R5701 T6593 T6593 ROOT counterstained,counterstained
R5702 T6594 T6593 prep with,counterstained
R5703 T6595 T6596 nummod 4,′
R5704 T6596 T6600 nummod ′,dihydrochloride
R5705 T6597 T6599 punct ",6",diamidino-2-phenylindole
R5706 T6598 T6599 punct -,diamidino-2-phenylindole
R5707 T6599 T6600 compound diamidino-2-phenylindole,dihydrochloride
R5708 T6600 T6594 pobj dihydrochloride,with
R5709 T6601 T6600 punct (,dihydrochloride
R5710 T6602 T6600 appos DAPI,dihydrochloride
R5711 T6603 T6600 punct ),dihydrochloride
R5712 T6604 T6600 punct ",",dihydrochloride
R5713 T6605 T6611 det a,stain
R5714 T6606 T6611 amod fluorescent,stain
R5715 T6607 T6609 amod blue,indole
R5716 T6608 T6609 amod nuclear,indole
R5717 T6609 T6611 compound indole,stain
R5718 T6610 T6611 compound chromatin,stain
R5719 T6611 T6600 appos stain,dihydrochloride
R5720 T6612 T6593 punct ",",counterstained
R5721 T6613 T6593 cc and,counterstained
R5722 T6614 T6593 conj mounted,counterstained
R5723 T6615 T6614 prep in,mounted
R5724 T6616 T6615 pobj PBS,in
R5725 T6617 T6614 punct :,mounted
R5726 T6618 T6614 conj glycerol,mounted
R5727 T6619 T6618 punct (,glycerol
R5728 T6620 T6621 nummod 50,∶
R5729 T6621 T6618 appos ∶,glycerol
R5730 T6622 T6621 nummod 50,∶
R5731 T6623 T6618 punct ),glycerol
R5732 T6624 T6593 punct .,counterstained
R5733 T6625 T6627 det The,signal
R5734 T6626 T6627 amod immunopositive,signal
R5735 T6627 T6629 nsubjpass signal,characterised
R5736 T6628 T6629 auxpass was,characterised
R5737 T6629 T6629 ROOT characterised,characterised
R5738 T6630 T6629 advcl using,characterised
R5739 T6631 T6632 nmod laser,scanning
R5740 T6632 T6630 dobj scanning,using
R5741 T6633 T6634 amod confocal,microscopy
R5742 T6634 T6632 dobj microscopy,scanning
R5743 T6635 T6632 prep on,scanning
R5744 T6636 T6642 det a,cytometer
R5745 T6637 T6639 nmod Leica,NT/SP
R5746 T6638 T6639 compound TCS,NT/SP
R5747 T6639 T6642 nmod NT/SP,cytometer
R5748 T6640 T6642 amod interactive,cytometer
R5749 T6641 T6642 compound laser,cytometer
R5750 T6642 T6635 pobj cytometer,on
R5751 T6643 T6642 acl equipped,cytometer
R5752 T6644 T6643 prep with,equipped
R5753 T6645 T6646 compound confocal,optics
R5754 T6646 T6644 pobj optics,with
R5782 T6674 T6675 det the,primary
R5783 T6675 T6673 pobj primary,without
R5784 T6676 T6677 auxpass were,used
R5785 T6677 T6677 ROOT used,used
R5786 T6678 T6677 prep as,used
R5787 T6679 T6678 pobj controls,as
R5788 T6680 T6677 punct .,used
R5789 T6681 T6682 advmod Positively,stained
R5790 T6682 T6683 amod stained,nuclei
R5791 T6683 T6688 nsubjpass nuclei,counted
R5792 T6684 T6683 cc and,nuclei
R5793 T6685 T6686 amod total,cells
R5794 T6686 T6683 conj cells,nuclei
R5795 T6687 T6688 auxpass were,counted
R5796 T6688 T6688 ROOT counted,counted
R5797 T6689 T6688 punct (,counted
R5798 T6690 T6688 npadvmod 500,counted
R5799 T6691 T6688 punct ),counted
R5800 T6692 T6688 prep on,counted
R5801 T6693 T6694 det each,slide
R5802 T6694 T6692 pobj slide,on
R5803 T6695 T6694 prep with,slide
R5804 T6696 T6697 det the,observer
R5805 T6697 T6695 pobj observer,with
R5806 T6698 T6688 conj blinded,counted
R5807 T6699 T6698 prep to,blinded
R5808 T6700 T6701 det the,treatment
R5809 T6701 T6699 pobj treatment,to
R5810 T6702 T6688 punct .,counted
R5958 T6937 T6938 compound GATA-3-GFP,Construct
R5959 T6938 T6948 nsubjpass Construct,obtained
R5960 T6939 T6941 det The,clone
R5961 T6940 T6941 compound GATA-3,clone
R5962 T6941 T6938 appos clone,Construct
R5963 T6942 T6943 punct (,BC003070
R5964 T6943 T6941 appos BC003070,clone
R5965 T6944 T6941 punct ),clone
R5966 T6945 T6946 amod complete,cDNA
R5967 T6946 T6948 nsubjpass cDNA,obtained
R5968 T6947 T6948 auxpass was,obtained
R5969 T6948 T6948 ROOT obtained,obtained
R5970 T6949 T6948 prep from,obtained
R5971 T6950 T6952 compound Invitrogen,Technologies
R5972 T6951 T6952 compound Life,Technologies
R5973 T6952 T6949 pobj Technologies,from
R5974 T6953 T6948 prep as,obtained
R5975 T6954 T6962 det a,insert
R5976 T6955 T6958 nummod 5,EcoRI/3
R5977 T6956 T6958 punct ′,EcoRI/3
R5978 T6957 T6958 punct -,EcoRI/3
R5979 T6958 T6962 compound EcoRI/3,insert
R5980 T6959 T6961 punct ′,XhoI
R5981 T6960 T6961 punct -,XhoI
R5982 T6961 T6962 compound XhoI,insert
R5983 T6962 T6953 pobj insert,as
R5984 T6963 T6962 prep of,insert
R5985 T6964 T6963 pobj GATA-3,of
R5986 T6965 T6962 prep in,insert
R5987 T6966 T6968 det the,vector
R5988 T6967 T6968 compound pOTB7,vector
R5989 T6968 T6965 pobj vector,in
R5990 T6969 T6948 punct .,obtained
R5991 T6970 T6972 nsubjpass GATA-3,excised
R5992 T6971 T6972 auxpass was,excised
R5993 T6972 T6972 ROOT excised,excised
R5994 T6973 T6972 prep from,excised
R5995 T6974 T6973 pobj pOTB7,from
R5996 T6975 T6972 advcl using,excised
R5997 T6976 T6977 compound XhoI,digestion
R5998 T6977 T6975 dobj digestion,using
R5999 T6978 T6977 cc and,digestion
R6000 T6979 T6977 conj pEGFP-C2,digestion
R6001 T6980 T6981 punct (,Clontech
R6002 T6981 T6977 appos Clontech,digestion
R6003 T6982 T6981 punct ",",Clontech
R6004 T6983 T6981 conj Saint-Germain-en-Laye,Clontech
R6005 T6984 T6983 punct ",",Saint-Germain-en-Laye
R6006 T6985 T6983 conj France,Saint-Germain-en-Laye
R6007 T6986 T6981 punct ),Clontech
R6008 T6987 T6988 auxpass was,digested
R6009 T6988 T6972 advcl digested,excised
R6010 T6989 T6988 prep with,digested
R6011 T6990 T6989 pobj BamHI,with
R6012 T6991 T6972 punct .,excised
R6013 T6992 T6994 nsubjpass DNA,recovered
R6014 T6993 T6994 auxpass was,recovered
R6015 T6994 T6994 ROOT recovered,recovered
R6016 T6995 T6994 agent by,recovered
R6017 T6996 T6997 compound phenol,extraction
R6018 T6997 T6995 pobj extraction,by
R6019 T6998 T6997 cc and,extraction
R6020 T6999 T7000 compound ethanol,precipitation
R6021 T7000 T6997 conj precipitation,extraction
R6022 T7001 T6994 punct ",",recovered
R6023 T7002 T6994 cc and,recovered
R6024 T7003 T7006 preconj both,fragment
R6025 T7004 T7006 det the,fragment
R6026 T7005 T7006 compound GATA-3,fragment
R6027 T7006 T7029 nsubjpass fragment,inactivated
R6028 T7007 T7006 cc and,fragment
R6029 T7008 T7010 det the,vector
R6030 T7009 T7010 compound pEGFP-C2,vector
R6031 T7010 T7006 conj vector,fragment
R6032 T7011 T7006 acl blunt-ended,fragment
R6033 T7012 T7011 agent by,blunt-ended
R6034 T7013 T7012 pobj incubation,by
R6035 T7014 T7011 prep with,blunt-ended
R6036 T7015 T7014 pobj Klenow,with
R6037 T7016 T7015 punct (,Klenow
R6038 T7017 T7018 compound Bioline,Bio-27029
R6039 T7018 T7015 appos Bio-27029,Klenow
R6040 T7019 T7015 punct ),Klenow
R6041 T7020 T7011 prep for,blunt-ended
R6042 T7021 T7022 nummod 30,min
R6043 T7022 T7020 pobj min,for
R6044 T7023 T7022 prep at,min
R6045 T7024 T7025 nummod 37,°
R6046 T7025 T7027 nummod °,Klenow
R6047 T7026 T7027 compound C.,Klenow
R6048 T7027 T7023 pobj Klenow,at
R6049 T7028 T7029 auxpass was,inactivated
R6050 T7029 T6994 conj inactivated,recovered
R6051 T7030 T7029 agent by,inactivated
R6052 T7031 T7030 pobj incubation,by
R6053 T7032 T7029 prep for,inactivated
R6054 T7033 T7034 nummod 10,min
R6055 T7034 T7032 pobj min,for
R6056 T7035 T7034 prep at,min
R6057 T7036 T7037 nummod 75,°
R6058 T7037 T7039 nummod °,DNA
R6059 T7038 T7039 compound C.,DNA
R6060 T7039 T7035 pobj DNA,at
R6061 T7040 T7041 auxpass was,recovered
R6062 T7041 T6994 conj recovered,recovered
R6063 T7042 T7041 agent by,recovered
R6064 T7043 T7044 compound phenol,extraction
R6065 T7044 T7042 pobj extraction,by
R6066 T7045 T7044 cc and,extraction
R6067 T7046 T7047 compound ethanol,precipitation
R6068 T7047 T7044 conj precipitation,extraction
R6069 T7048 T7041 punct ",",recovered
R6070 T7049 T6994 cc and,recovered
R6071 T7050 T7054 preconj both,fragment
R6072 T7051 T7054 det the,fragment
R6073 T7052 T7054 amod blunt-ended,fragment
R6074 T7053 T7054 compound GATA-3,fragment
R6075 T7054 T7061 nsubjpass fragment,digested
R6076 T7055 T7054 cc and,fragment
R6077 T7056 T7058 det the,vector
R6078 T7057 T7058 compound GFP,vector
R6079 T7058 T7054 conj vector,fragment
R6080 T7059 T7061 auxpass were,digested
R6081 T7060 T7061 advmod subsequently,digested
R6082 T7061 T6994 conj digested,recovered
R6083 T7062 T7061 prep with,digested
R6084 T7063 T7062 pobj EcoRI,with
R6085 T7064 T7061 prep before,digested
R6086 T7065 T7070 det the,′
R6087 T7066 T7070 nummod 5,′
R6088 T7067 T7069 punct ′,EcoRI/3
R6089 T7068 T7069 punct -,EcoRI/3
R6090 T7069 T7070 compound EcoRI/3,′
R6091 T7070 T7064 pobj ′,before
R6092 T7071 T7074 amod blunt,fragment
R6093 T7072 T7074 compound end,fragment
R6094 T7073 T7074 compound GATA-3,fragment
R6095 T7074 T7076 nsubjpass fragment,inserted
R6096 T7075 T7076 auxpass was,inserted
R6097 T7076 T6994 conj inserted,recovered
R6098 T7077 T7076 prep into,inserted
R6099 T7078 T7083 det the,′
R6100 T7079 T7082 nummod 5,EcoRI/3
R6101 T7080 T7082 punct ′,EcoRI/3
R6247 T7294 T7286 appos serum,h
R6248 T7295 T7294 prep in,serum
R6249 T7296 T7295 pobj RPMI1640,in
R6250 T7297 T7298 nummod +15,L-glutamine
R6251 T7298 T7294 appos L-glutamine,serum
R6252 T7299 T7286 punct ),h
R6253 T7300 T7258 prep according,transfected
R6254 T7301 T7300 prep to,according
R6255 T7302 T7305 det the,protocol
R6256 T7303 T7305 amod general,protocol
R6257 T7304 T7305 compound Amaxa,protocol
R6258 T7305 T7301 pobj protocol,to
R6412 T7474 T7475 compound Microscopy,HuT-78
R6413 T7475 T7476 compound HuT-78,cells
R6414 T7476 T7480 nsubjpass cells,maintained
R6415 T7477 T7476 acl expressing,cells
R6416 T7478 T7477 dobj GATA-3-GFP,expressing
R6417 T7479 T7480 auxpass were,maintained
R6418 T7480 T7480 ROOT maintained,maintained
R6419 T7481 T7480 prep at,maintained
R6420 T7482 T7483 nummod 37,°
R6421 T7483 T7484 nummod °,C
R6422 T7484 T7481 pobj C,at
R6423 T7485 T7484 prep in,C
R6424 T7486 T7487 compound growth,medium
R6425 T7487 T7485 pobj medium,in
R6426 T7488 T7480 prep in,maintained
R6427 T7489 T7493 det a,chamber
R6428 T7490 T7493 amod closed,chamber
R6429 T7491 T7493 nummod FCS2,chamber
R6430 T7492 T7493 compound perfusion,chamber
R6431 T7493 T7488 pobj chamber,in
R6432 T7494 T7495 punct (,Bioptechs
R6433 T7495 T7493 appos Bioptechs,chamber
R6434 T7496 T7495 punct ",",Bioptechs
R6435 T7497 T7495 conj Butler,Bioptechs
R6436 T7498 T7497 punct ",",Butler
R6437 T7499 T7497 conj Pennsylvania,Butler
R6438 T7500 T7499 punct ",",Pennsylvania
R6439 T7501 T7499 conj USA,Pennsylvania
R6440 T7502 T7480 punct ),maintained
R6441 T7503 T7480 conj combined,maintained
R6442 T7504 T7503 prep with,combined
R6443 T7505 T7507 det an,heater
R6444 T7506 T7507 amod objective,heater
R6445 T7507 T7504 pobj heater,with
R6446 T7508 T7507 punct (,heater
R6447 T7509 T7507 appos Bioptechs,heater
R6448 T7510 T7507 punct ),heater
R6449 T7511 T7503 prep on,combined
R6450 T7512 T7513 det the,stage
R6451 T7513 T7511 pobj stage,on
R6452 T7514 T7518 det a,microscope
R6453 T7515 T7516 compound Zeiss,Axiovert
R6454 T7516 T7518 nmod Axiovert,microscope
R6455 T7517 T7518 nummod 200,microscope
R6456 T7518 T7503 npadvmod microscope,combined
R6457 T7519 T7520 punct (,Thornwood
R6458 T7520 T7518 appos Thornwood,microscope
R6459 T7521 T7520 punct ",",Thornwood
R6460 T7522 T7523 compound New,York
R6461 T7523 T7520 npadvmod York,Thornwood
R6462 T7524 T7523 punct ",",York
R6463 T7525 T7520 appos USA,Thornwood
R6464 T7526 T7520 punct ),Thornwood
R6465 T7527 T7480 punct .,maintained
R6466 T7528 T7530 nsubjpass Observations,made
R6467 T7529 T7530 auxpass were,made
R6468 T7530 T7530 ROOT made,made
R6469 T7531 T7530 agent by,made
R6470 T7532 T7534 nummod 40,1.0
R6471 T7533 T7534 nummod ×,1.0
R6472 T7534 T7531 pobj 1.0,by
R6473 T7535 T7538 nmod NA,lens
R6474 T7536 T7538 amod oil-immersion,lens
R6475 T7537 T7538 amod objective,lens
R6476 T7538 T7545 nmod lens,images
R6477 T7539 T7538 punct ",",lens
R6478 T7540 T7538 cc and,lens
R6479 T7541 T7538 conj fluorescence,lens
R6480 T7542 T7541 cc and,fluorescence
R6481 T7543 T7541 conj phase,fluorescence
R6482 T7544 T7545 compound contrast,images
R6483 T7545 T7547 nsubjpass images,gathered
R6484 T7546 T7547 auxpass were,gathered
R6485 T7547 T7530 conj gathered,made
R6486 T7548 T7547 advcl using,gathered
R6487 T7549 T7551 det a,ORCA-ER
R6488 T7550 T7551 compound Hamamatsu,ORCA-ER
R6489 T7551 T7548 dobj ORCA-ER,using
R6490 T7552 T7547 conj charged,gathered
R6491 T7553 T7555 amod coupled,camera
R6492 T7554 T7555 compound device,camera
R6493 T7555 T7552 dobj camera,charged
R6494 T7556 T7564 punct (,driven
R6495 T7557 T7564 dep Bridgewater,driven
R6496 T7558 T7557 punct ",",Bridgewater
R6497 T7559 T7560 compound New,Jersey
R6498 T7560 T7557 conj Jersey,Bridgewater
R6499 T7561 T7560 punct ",",Jersey
R6500 T7562 T7560 conj USA,Jersey
R6501 T7563 T7564 punct ),driven
R6502 T7564 T7552 advcl driven,charged
R6503 T7565 T7564 agent by,driven
R6504 T7566 T7567 compound Openlab,software
R6505 T7567 T7565 pobj software,by
R6506 T7568 T7569 punct (,Improvision
R6507 T7569 T7567 appos Improvision,software
R6508 T7570 T7569 punct ",",Improvision
R6509 T7571 T7569 npadvmod Coventry,Improvision
R6510 T7572 T7571 punct ",",Coventry
R6511 T7573 T7571 appos UK,Coventry
R6512 T7574 T7571 punct ),Coventry
R6513 T7575 T7547 punct .,gathered
R6514 T7576 T7578 nsubjpass Photographs,taken
R6515 T7577 T7578 auxpass were,taken
R6516 T7578 T7578 ROOT taken,taken
R6517 T7579 T7578 prep at,taken
R6518 T7580 T7579 pobj 0,at
R6519 T7581 T7580 punct ",",0
R6520 T7582 T7580 appos 30,0
R6521 T7583 T7580 punct ",",0
R6522 T7584 T7580 appos 60,0
R6523 T7585 T7584 punct ",",60
R6524 T7586 T7584 conj 120,60
R6525 T7587 T7578 punct ",",taken
R6526 T7588 T7578 cc and,taken
R6527 T7589 T7590 nummod 240,min
R6528 T7590 T7578 conj min,taken
R6529 T7591 T7578 punct .,taken
R6614 T7691 T7693 compound Densitometric,Densitometry
R6615 T7692 T7693 compound Analysis,Densitometry
R6616 T7693 T7698 nsubjpass Densitometry,performed
R6617 T7694 T7693 prep of,Densitometry
R6618 T7695 T7696 compound ECL,immunoblots
R6619 T7696 T7694 pobj immunoblots,of
R6620 T7697 T7698 auxpass was,performed
R6621 T7698 T7698 ROOT performed,performed
R6622 T7699 T7698 advcl using,performed
R6623 T7700 T7703 nmod Gelworks,software
R6624 T7701 T7703 nmod ID,software
R6625 T7702 T7703 amod intermediate,software
R6626 T7703 T7699 dobj software,using
R6627 T7704 T7706 punct (,Products
R6628 T7705 T7706 compound Ultraviolet,Products
R6629 T7706 T7703 appos Products,software
R6630 T7707 T7706 punct ",",Products
R6631 T7708 T7706 conj Cambridgeshire,Products
R6632 T7709 T7708 punct ",",Cambridgeshire
R6633 T7710 T7708 appos UK,Cambridgeshire
R6634 T7711 T7708 punct ),Cambridgeshire
R6635 T7712 T7698 punct .,performed
R6636 T7713 T7717 advmod Briefly,scanned
R6637 T7714 T7717 punct ",",scanned
R6638 T7715 T7717 nsubjpass immunoblots,scanned
R6639 T7716 T7717 auxpass were,scanned
R6640 T7717 T7717 ROOT scanned,scanned
R6641 T7718 T7717 cc and,scanned
R6642 T7719 T7721 nsubjpass gates,drawn
R6643 T7720 T7721 auxpass were,drawn
R6644 T7721 T7717 conj drawn,scanned
R6645 T7722 T7721 advmod tightly,drawn
R6646 T7723 T7721 prep around,drawn
R6647 T7724 T7725 det each,band
R6648 T7725 T7723 pobj band,around
R6649 T7726 T7721 punct .,drawn
R6650 T7727 T7728 compound Background,values
R6651 T7728 T7733 nsubjpass values,subtracted
R6652 T7729 T7728 prep from,values
R6653 T7730 T7731 det each,lane
R6654 T7731 T7729 pobj lane,from
R6655 T7732 T7733 auxpass were,subtracted
R6656 T7733 T7733 ROOT subtracted,subtracted
R6657 T7734 T7735 aux to,normalize
R6658 T7735 T7733 xcomp normalize,subtracted
R6659 T7736 T7737 det each,measurement
R6660 T7737 T7735 dobj measurement,normalize
R6661 T7738 T7733 punct .,subtracted
R6662 T7739 T7740 det The,bands
R6663 T7740 T7742 nsubjpass bands,quantified
R6664 T7741 T7742 auxpass were,quantified
R6665 T7742 T7742 ROOT quantified,quantified
R6666 T7743 T7742 advcl using,quantified
R6667 T7744 T7746 det the,software
R6668 T7745 T7746 compound Gelworks,software
R6669 T7746 T7743 dobj software,using
R6670 T7747 T7742 punct .,quantified
R6671 T7748 T7750 det All,blots
R6672 T7749 T7750 amod Western,blots
R6673 T7750 T7752 nsubjpass blots,exposed
R6674 T7751 T7752 auxpass were,exposed
R6675 T7752 T7752 ROOT exposed,exposed
R6676 T7753 T7752 prep to,exposed
R6677 T7754 T7753 pobj film,to
R6678 T7755 T7754 prep for,film
R6679 T7756 T7757 amod varying,lengths
R6680 T7757 T7755 pobj lengths,for
R6681 T7758 T7757 prep of,lengths
R6682 T7759 T7758 pobj time,of
R6683 T7760 T7752 punct ",",exposed
R6684 T7761 T7752 cc and,exposed
R6685 T7762 T7763 advmod only,films
R6686 T7763 T7770 nsubjpass films,selected
R6687 T7764 T7763 acl generating,films
R6688 T7765 T7766 amod subsaturating,levels
R6689 T7766 T7764 dobj levels,generating
R6690 T7767 T7766 prep of,levels
R6691 T7768 T7767 pobj intensity,of
R6692 T7769 T7770 auxpass were,selected
R6693 T7770 T7752 conj selected,exposed
R6694 T7771 T7770 prep for,selected
R6695 T7772 T7773 amod densitometric,evaluation
R6696 T7773 T7771 pobj evaluation,for
R6697 T7774 T7770 punct .,selected
R6852 T7934 T7935 compound Statistical,Analysis
R6853 T7935 T7936 compound Analysis,Data
R6854 T7936 T7944 nsubjpass Data,presented
R6855 T7937 T7936 prep from,Data
R6856 T7938 T7942 nummod three,experiments
R6857 T7939 T7938 cc or,three
R6858 T7940 T7938 conj more,three
R6859 T7941 T7942 amod independent,experiments
R6860 T7942 T7937 pobj experiments,from
R6861 T7943 T7944 auxpass are,presented
R6862 T7944 T7944 ROOT presented,presented
R6863 T7945 T7944 prep as,presented
R6864 T7946 T7950 det the,error
R6865 T7947 T7950 amod mean,error
R6866 T7948 T7950 compound ±,error
R6867 T7949 T7950 compound standard,error
R6868 T7950 T7945 pobj error,as
R6869 T7951 T7950 prep of,error
R6870 T7952 T7953 det the,mean
R6871 T7953 T7951 pobj mean,of
R6872 T7954 T7955 punct (,SEM
R6873 T7955 T7953 appos SEM,mean
R6874 T7956 T7955 punct ),SEM
R6875 T7957 T7950 punct ",",error
R6876 T7958 T7950 prep except,error
R6877 T7959 T7960 advmod where,stated
R6878 T7960 T7958 pcomp stated,except
R6879 T7961 T7944 cc and,presented
R6880 T7962 T7963 auxpass were,compared
R6881 T7963 T7944 conj compared,presented
R6882 T7964 T7963 advcl using,compared
R6930 T8012 T8009 dobj test,signed
R6931 T8013 T8009 punct .,signed
R6932 T8014 T8019 nsubjpass Data,presented
R6933 T8015 T8014 prep from,Data
R6934 T8016 T8017 det this,analysis
R6935 T8017 T8015 pobj analysis,from
R6936 T8018 T8019 auxpass are,presented
R6937 T8019 T8019 ROOT presented,presented
R6938 T8020 T8019 prep as,presented
R6939 T8021 T8023 det a,plot
R6940 T8022 T8023 compound box-and-whiskers,plot
R6941 T8023 T8020 pobj plot,as
R6942 T8024 T8019 punct .,presented
R6943 T8025 T8027 poss Friedman,test
R6944 T8026 T8025 case 's,Friedman
R6945 T8027 T8029 nsubjpass test,used
R6946 T8028 T8029 auxpass was,used
R6947 T8029 T8029 ROOT used,used
R6948 T8030 T8035 mark as,obtained
R6949 T8031 T8033 nummod three,measures
R6950 T8032 T8033 amod matched,measures
R6951 T8033 T8035 nsubjpass measures,obtained
R6952 T8034 T8035 auxpass were,obtained
R6953 T8035 T8029 advcl obtained,used
R6954 T8036 T8035 advcl using,obtained
R6955 T8037 T8036 dobj placebo,using
R6956 T8038 T8037 punct ",",placebo
R6957 T8039 T8040 nummod 100,µg
R6958 T8040 T8037 conj µg,placebo
R6959 T8041 T8040 punct ",",µg
R6960 T8042 T8040 cc and,µg
R6986 T8068 T8069 amod limited,numbers
R6987 T8069 T8065 pobj numbers,due
R6988 T8070 T8069 prep of,numbers
R6989 T8071 T8070 pobj participants,of
R6990 T8072 T8071 acl analysed,participants
R6991 T8073 T8061 punct (,distribution
R6992 T8074 T8061 appos seven,distribution
R6993 T8075 T8061 punct ),distribution
R6994 T8076 T8058 punct .,assume
R6995 T8077 T8079 det The,hypothesis
R6996 T8078 T8079 amod null,hypothesis
R6997 T8079 T8081 nsubjpass hypothesis,rejected
R6998 T8080 T8081 auxpass was,rejected
R6999 T8081 T8081 ROOT rejected,rejected
R7000 T8082 T8081 prep at,rejected
R7001 T8083 T8084 compound p,<
R7002 T8084 T8085 compound <,0.05
R7003 T8085 T8082 pobj 0.05,at
R7004 T8086 T8081 punct .,rejected
R7296 T8451 T8452 det The,Effect
R7297 T8452 T8463 nsubj Effect,are
R7298 T8453 T8452 prep of,Effect
R7299 T8454 T8453 pobj Corticosteroids,of
R7300 T8455 T8452 prep on,Effect
R7301 T8456 T8458 compound GATA-3,Translocation
R7302 T8457 T8458 compound Nuclear,Translocation
R7303 T8458 T8455 pobj Translocation,on
R7304 T8459 T8458 cc and,Translocation
R7305 T8460 T8462 compound IL-4,Corticosteroids
R7306 T8461 T8462 compound mRNA,Corticosteroids
R7307 T8462 T8458 conj Corticosteroids,Translocation
R7308 T8463 T8463 ROOT are,are
R7309 T8464 T8463 acomp effective,are
R7310 T8465 T8464 prep in,effective
R7311 T8466 T8465 pcomp inhibiting,in
R7312 T8467 T8470 amod GATA-3-regulated,expression
R7313 T8468 T8469 compound IL-4,gene
R7314 T8469 T8470 compound gene,expression
R7315 T8470 T8466 dobj expression,inhibiting
R7316 T8471 T8466 prep in,inhibiting
R7317 T8472 T8471 pobj vitro,in
R7318 T8473 T8471 cc and,in
R7319 T8474 T8471 conj in,in
R7320 T8475 T8474 pobj vivo,in
R7321 T8476 T8478 nmod [,]
R7322 T8477 T8478 nummod 32,]
R7323 T8478 T8463 attr ],are
R7324 T8479 T8463 punct .,are
R7325 T8480 T8482 nsubj We,investigated
R7326 T8481 T8482 advmod therefore,investigated
R7327 T8482 T8482 ROOT investigated,investigated
R7328 T8483 T8485 mark whether,affect
R7329 T8484 T8485 nsubj corticosteroids,affect
R7347 T8502 T8502 ROOT resulted,resulted
R7348 T8503 T8502 prep in,resulted
R7349 T8504 T8508 det a,translocation
R7350 T8505 T8508 amod rapid,translocation
R7351 T8506 T8508 nmod cytoplasmic/nuclear,translocation
R7352 T8507 T8508 compound GATA-3,translocation
R7353 T8508 T8503 pobj translocation,in
R7354 T8509 T8510 punct (,Figure
R7355 T8510 T8511 nmod Figure,1A
R7356 T8511 T8508 appos 1A,translocation
R7357 T8512 T8508 punct ),translocation
R7358 T8513 T8502 punct ",",resulted
R7359 T8514 T8502 advcl confirming,resulted
R7360 T8515 T8517 poss our,results
R7361 T8516 T8517 amod previous,results
R7362 T8517 T8514 dobj results,confirming
R7363 T8518 T8520 nmod [,]
R7364 T8519 T8520 nummod 12,]
R7365 T8520 T8517 appos ],results
R7366 T8521 T8502 punct .,resulted
R7367 T8522 T8524 nsubj We,confirmed
R7368 T8523 T8524 advmod also,confirmed
R7369 T8524 T8524 ROOT confirmed,confirmed
R7370 T8525 T8527 det a,separation
R7371 T8526 T8527 amod clear,separation
R7372 T8527 T8524 dobj separation,confirmed
R7373 T8528 T8527 prep of,separation
R7374 T8529 T8532 amod nuclear,fractions
R7375 T8530 T8529 cc and,nuclear
R7376 T8531 T8529 conj cytosolic,nuclear
R7377 T8532 T8528 pobj fractions,of
R7378 T8533 T8534 mark as,indicated
R7379 T8534 T8527 advcl indicated,separation
R7380 T8535 T8534 agent by,indicated
R7381 T8536 T8535 pobj histone,by
R7382 T8537 T8536 nummod H1,histone
R7383 T8538 T8536 cc and,histone
R7384 T8539 T8540 nummod MEK-1,markers
R7385 T8540 T8536 conj markers,histone
R7386 T8541 T8543 punct (,1B
R7387 T8542 T8543 compound Figure,1B
R7388 T8543 T8540 appos 1B,markers
R7389 T8544 T8543 punct ),1B
R7390 T8545 T8524 punct .,confirmed
R7391 T8546 T8550 det The,FP
R7392 T8547 T8550 amod potent,FP
R7393 T8548 T8550 amod topical,FP
R7394 T8549 T8550 amod corticosteroid,FP
R7395 T8550 T8551 nsubj FP,caused
R7396 T8551 T8551 ROOT caused,caused
R7397 T8552 T8553 amod sustained,loss
R7398 T8553 T8551 dobj loss,caused
R7399 T8554 T8553 prep of,loss
R7400 T8555 T8557 amod nuclear,expression
R7401 T8556 T8557 amod GATA-3,expression
R7402 T8557 T8554 pobj expression,of
R7403 T8558 T8557 cc and,expression
R7404 T8559 T8560 amod cytoplasmic,retention
R7405 T8560 T8557 conj retention,expression
R7406 T8561 T8557 prep of,expression
R7407 T8562 T8561 pobj GATA-3,of
R7408 T8563 T8553 prep at,loss
R7409 T8564 T8563 pobj concentrations,at
R7410 T8565 T8564 acl ranging,concentrations
R7411 T8566 T8565 prep from,ranging
R7412 T8567 T8568 nummod 10,−
R7413 T8568 T8566 pobj −,from
R7414 T8569 T8571 quantmod 12,10
R7415 T8570 T8571 quantmod to,10
R7416 T8571 T8572 nummod 10,−
R7417 T8572 T8574 nummod −,M
R7418 T8573 T8574 nummod 8,M
R7419 T8574 T8566 pobj M,from
R7420 T8575 T8574 punct ",",M
R7421 T8576 T8577 nsubj which,cover
R7422 T8577 T8574 relcl cover,M
R7423 T8578 T8580 det the,range
R7424 T8579 T8580 amod therapeutic,range
R7425 T8580 T8577 dobj range,cover
R7426 T8581 T8583 nmod [,]
R7427 T8582 T8583 nummod 37,]
R7428 T8583 T8580 appos ],range
R7429 T8584 T8551 punct .,caused
R7430 T8585 T8586 det This,effect
R7431 T8586 T8587 nsubj effect,was
R7432 T8587 T8587 ROOT was,was
R7433 T8588 T8587 attr concentration,was
R7434 T8589 T8588 punct -,concentration
R7435 T8590 T8588 cc and,concentration
R7436 T8591 T8588 conj time-dependent,concentration
R7437 T8592 T8587 punct ",",was
R7438 T8593 T8587 prep with,was
R7439 T8594 T8596 det a,effect
R7440 T8595 T8596 amod peak,effect
R7441 T8596 T8593 pobj effect,with
R7442 T8597 T8596 prep of,effect
R7443 T8598 T8597 pobj 11.6-fold,of
R7444 T8599 T8596 prep at,effect
R7445 T8600 T8601 nummod 30,min
R7446 T8601 T8599 pobj min,at
R7447 T8602 T8601 prep at,min
R7448 T8603 T8604 det a,concentration
R7449 T8604 T8602 pobj concentration,at
R7450 T8605 T8604 prep of,concentration
R7451 T8606 T8608 quantmod 10,8
R7452 T8607 T8608 quantmod −,8
R7453 T8608 T8605 pobj 8,of
R7454 T8609 T8608 quantmod M,8
R7455 T8610 T8612 punct (,1C
R7456 T8611 T8612 compound Figure,1C
R7457 T8612 T8609 appos 1C,M
R7458 T8613 T8612 punct ),1C
R7459 T8614 T8587 cc and,was
R7460 T8615 T8616 auxpass was,associated
R7461 T8616 T8624 parataxis associated,stimulated
R7462 T8617 T8616 prep with,associated
R7463 T8618 T8619 amod marked,reductions
R7464 T8619 T8617 pobj reductions,with
R7465 T8620 T8619 prep in,reductions
R7466 T8621 T8622 amod anti-CD3,/
R7467 T8622 T8620 pobj /,in
R7468 T8623 T8622 nummod CD28,/
R7469 T8624 T8587 conj stimulated,was
R7470 T8625 T8624 dobj IL-4,stimulated
R7471 T8626 T8625 cc and,IL-4
R7472 T8627 T8625 conj IL-5,IL-4
R7473 T8628 T8629 compound mRNA,expression
R7474 T8629 T8625 conj expression,IL-4
R7475 T8630 T8631 punct (,Figure
R7476 T8631 T8629 appos Figure,expression
R7477 T8632 T8631 nummod 1D,Figure
R7478 T8633 T8631 punct ),Figure
R7479 T8634 T8631 cc and,Figure
R7480 T8635 T8636 det a,loss
R7481 T8636 T8625 appos loss,IL-4
R7487 T8642 T8644 amod native,promoter
R7849 T9110 T9111 nsubj GR,Competes
R7850 T9111 T9111 ROOT Competes,Competes
R7851 T9112 T9111 prep with,Competes
R7852 T9113 T9112 pobj GATA-3,with
R7853 T9114 T9113 prep for,GATA-3
R7854 T9115 T9114 pobj Importin-α,for
R7855 T9116 T9117 nsubj We,confirmed
R7856 T9117 T9111 ccomp confirmed,Competes
R7857 T9118 T9117 cc and,confirmed
R7858 T9119 T9117 conj extended,confirmed
R7859 T9120 T9121 amod previous,data
R7860 T9121 T9119 dobj data,extended
R7861 T9122 T9124 nmod [,]
R7862 T9123 T9124 nummod 20,]
R7863 T9124 T9126 nsubj ],show
R7864 T9125 T9126 aux to,show
R7865 T9126 T9119 advcl show,extended
R7866 T9127 T9126 dobj that,show
R7867 T9128 T9129 compound ligand-activated,GR
R7868 T9129 T9127 nsubj GR,that
R7869 T9130 T9132 advmod as,as
R7870 T9131 T9132 advmod well,as
R7871 T9132 T9129 cc as,GR
R7872 T9133 T9134 amod GATA-3,uses
R7873 T9134 T9129 conj uses,GR
R7874 T9135 T9129 conj importin-α,GR
R7875 T9136 T9135 prep for,importin-α
R7876 T9137 T9145 poss its,)
R7877 T9138 T9139 amod nuclear,import
R7878 T9139 T9145 nmod import,)
R7879 T9140 T9141 punct (,Figure
R7880 T9141 T9145 nmod Figure,)
R7881 T9142 T9141 nummod 2A,Figure
R7882 T9143 T9141 cc and,Figure
R7883 T9144 T9141 conj 2B,Figure
R7884 T9145 T9135 punct ),importin-α
R7885 T9146 T9111 punct .,Competes
R7886 T9147 T9148 det This,interaction
R7887 T9148 T9153 nsubj interaction,was
R7888 T9149 T9148 prep between,interaction
R7889 T9150 T9149 pobj GR,between
R7890 T9151 T9150 cc and,GR
R7891 T9152 T9150 conj importin-α,GR
R7892 T9153 T9153 ROOT was,was
R7893 T9154 T9153 acomp significant,was
R7894 T9155 T9153 prep at,was
R7895 T9156 T9155 pobj concentrations,at
R7896 T9157 T9158 advmod as,low
R7897 T9158 T9156 amod low,concentrations
R7898 T9159 T9158 prep as,low
R7899 T9160 T9161 nummod 10,−
R7900 T9161 T9159 pobj −,as
R7901 T9162 T9163 nummod 12,M
R7902 T9163 T9158 npadvmod M,low
R7903 T9164 T9153 cc and,was
R7904 T9165 T9166 auxpass was,maximal
R7905 T9166 T9153 conj maximal,was
R7906 T9167 T9166 prep with,maximal
R7907 T9168 T9170 quantmod 10,8
R7908 T9169 T9170 quantmod −,8
R7909 T9170 T9167 pobj 8,with
R7910 T9171 T9172 compound M,FP
R7911 T9172 T9170 quantmod FP,8
R7912 T9173 T9166 punct .,maximal
R7913 T9174 T9177 amod Subsequent,translocation
R7914 T9175 T9177 nmod GR,translocation
R7915 T9176 T9177 amod nuclear,translocation
R7916 T9177 T9178 nsubj translocation,was
R7917 T9178 T9178 ROOT was,was
R7918 T9179 T9178 acomp rapid,was
R7919 T9180 T9178 cc and,was
R7920 T9181 T9178 conj sustained,was
R7921 T9182 T9181 prep at,sustained
R7922 T9183 T9184 amod significant,levels
R7923 T9184 T9182 pobj levels,at
R7924 T9185 T9181 prep for,sustained
R7925 T9186 T9187 advmod at,least
R7926 T9187 T9188 advmod least,14
R7927 T9188 T9189 nummod 14,h
R7928 T9189 T9185 pobj h,for
R7929 T9190 T9192 punct (,2B
R7930 T9191 T9192 compound Figure,2B
R7931 T9192 T9189 appos 2B,h
R7932 T9193 T9192 punct ),2B
R7933 T9194 T9178 punct .,was
R7934 T9195 T9199 advcl Using,showed
R7935 T9196 T9197 amod IP-Western,blotting
R7936 T9197 T9195 dobj blotting,Using
R7937 T9198 T9199 nsubj we,showed
R7938 T9199 T9199 ROOT showed,showed
R7939 T9200 T9210 mark that,decreased
R7940 T9201 T9210 nsubj FP,decreased
R7941 T9202 T9201 prep at,FP
R7942 T9203 T9205 nummod 10,12
R7943 T9204 T9205 nummod −,12
R7944 T9205 T9202 pobj 12,at
R7945 T9206 T9209 nummod 10,M
R7946 T9207 T9209 nmod −,M
R7947 T9208 T9207 nummod 8,−
R7948 T9209 T9201 conj M,FP
R7949 T9210 T9199 ccomp decreased,showed
R7950 T9211 T9212 det the,association
R7951 T9212 T9210 dobj association,decreased
R7952 T9213 T9212 prep between,association
R7953 T9214 T9213 pobj GATA-3,between
R7954 T9215 T9214 cc and,GATA-3
R7955 T9216 T9214 conj importin-α,GATA-3
R7956 T9217 T9212 acl induced,association
R7957 T9218 T9217 agent by,induced
R7958 T9219 T9222 amod anti-CD3,stimulation
R7959 T9220 T9222 nmod /,stimulation
R7960 T9221 T9222 nummod CD28,stimulation
R7961 T9222 T9218 pobj stimulation,by
R7962 T9223 T9217 prep in,induced
R7963 T9224 T9226 det a,manner
R7964 T9225 T9226 amod concentration-dependent,manner
R7965 T9226 T9223 pobj manner,in
R7966 T9227 T9228 punct (,Figure
R7967 T9228 T9226 appos Figure,manner
R7968 T9229 T9228 npadvmod 2C,Figure
R7969 T9230 T9228 punct ),Figure
R7970 T9231 T9199 punct .,showed
R7971 T9232 T9242 prep In,demonstrated
R7972 T9233 T9232 pobj addition,In
R7973 T9234 T9242 punct ",",demonstrated
R7974 T9235 T9242 advcl using,demonstrated
R7975 T9236 T9237 amod GFP-labelled,GATA-3
R7976 T9237 T9235 dobj GATA-3,using
R7977 T9238 T9237 cc and,GATA-3
R7978 T9239 T9240 amod confocal,microscopy
R7979 T9240 T9237 conj microscopy,GATA-3
R7980 T9241 T9242 nsubj we,demonstrated
R7981 T9242 T9242 ROOT demonstrated,demonstrated
R7982 T9243 T9256 mark that,attenuated
R7983 T9244 T9246 amod GATA-3,import
R7984 T9245 T9246 amod nuclear,import
R7985 T9246 T9256 nsubjpass import,attenuated
R7986 T9247 T9246 prep following,import
R7987 T9248 T9249 compound anti-CD3,/
R7988 T9249 T9247 dobj /,following
R7989 T9250 T9251 nummod CD28,stimulation
R7990 T9251 T9246 appos stimulation,import
R7991 T9252 T9251 prep for,stimulation
R7992 T9253 T9254 nummod 30,min
R7993 T9254 T9252 pobj min,for
R7994 T9255 T9256 auxpass was,attenuated
R7995 T9256 T9242 ccomp attenuated,demonstrated
R7996 T9257 T9256 agent by,attenuated
R7997 T9258 T9257 pobj pretreatment,by
R7998 T9259 T9256 prep with,attenuated
R7999 T9260 T9259 pobj FP,with
R8000 T9261 T9260 punct (,FP
R8001 T9262 T9263 nummod 10,−
R8002 T9263 T9265 npadvmod −,M
R8003 T9264 T9265 nummod 8,M
R8004 T9265 T9260 appos M,FP
R8005 T9266 T9260 punct ),FP
R8006 T9267 T9268 punct (,Figure
R8007 T9268 T9260 appos Figure,FP
R8008 T9269 T9268 nummod 2D,Figure
R8009 T9270 T9242 punct ),demonstrated
R8010 T9271 T9242 punct .,demonstrated
R8744 T10194 T10198 nsubj Effect,inhibits
R8745 T10195 T10194 prep on,Effect
R8746 T10196 T10197 compound MKP-1,Dexamethasone
R8747 T10197 T10195 pobj Dexamethasone,on
R8748 T10198 T10198 ROOT inhibits,inhibits
R8749 T10199 T10201 nummod p38,function
R8750 T10200 T10201 compound MAPK,function
R8751 T10201 T10198 dobj function,inhibits
R8752 T10202 T10201 prep in,function
R8753 T10203 T10205 det a,type
R8754 T10204 T10205 compound cell,type
R8755 T10205 T10202 pobj type,in
R8756 T10206 T10207 amod specific,manner
R8757 T10207 T10201 conj manner,function
R8758 T10208 T10198 prep through,inhibits
R8759 T10209 T10211 det the,induction
R8760 T10210 T10211 amod rapid,induction
R8761 T10211 T10208 pobj induction,through
R8762 T10212 T10211 prep of,induction
R8763 T10213 T10215 det the,kinase
R8764 T10214 T10215 amod dual,kinase
R8765 T10215 T10212 pobj kinase,of
R8766 T10216 T10217 compound phosphatase,MKP-1
R8767 T10217 T10215 appos MKP-1,kinase
R8768 T10218 T10220 punct (,phosphatase-1
R8769 T10219 T10220 compound MAPK,phosphatase-1
R8770 T10220 T10217 appos phosphatase-1,MKP-1
R8771 T10221 T10220 punct ),phosphatase-1
R8772 T10222 T10217 punct ",",MKP-1
R8773 T10223 T10217 cc and,MKP-1
R8774 T10224 T10225 det this,effect
R8775 T10225 T10226 nsubj effect,lasts
R8776 T10226 T10215 relcl lasts,kinase
R8777 T10227 T10226 prep for,lasts
R8778 T10228 T10230 quantmod up,24
R8779 T10229 T10230 quantmod to,24
R8780 T10230 T10234 nummod 24,]
R8781 T10231 T10232 compound h,[
R8782 T10232 T10234 nmod [,]
R8783 T10233 T10232 nummod 28,[
R8784 T10234 T10227 pobj ],for
R8785 T10235 T10198 punct .,inhibits
R8786 T10236 T10243 nmod FP,treatment
R8787 T10237 T10239 punct (,−
R8788 T10238 T10239 nummod 10,−
R8789 T10239 T10243 nmod −,treatment
R8790 T10240 T10239 nummod 8,−
R8791 T10241 T10239 appos M,−
R8792 T10242 T10239 punct ),−
R8793 T10243 T10255 nsubj treatment,decreased
R8794 T10244 T10243 prep of,treatment
R8795 T10245 T10246 amod HuT-78,cells
R8796 T10246 T10244 pobj cells,of
R8797 T10247 T10246 acl activated,cells
R8798 T10248 T10247 agent by,activated
R8799 T10249 T10250 compound anti-CD3,/
R8800 T10250 T10248 pobj /,by
R8801 T10251 T10250 nummod CD28,/
R8802 T10252 T10247 prep in,activated
R8803 T10253 T10252 pobj vitro,in
R8804 T10254 T10255 advmod significantly,decreased
R8805 T10255 T10255 ROOT decreased,decreased
R8806 T10256 T10258 nummod p38,phosphorylation
R8807 T10257 T10258 compound MAPK,phosphorylation
R8808 T10258 T10255 dobj phosphorylation,decreased
R8809 T10259 T10261 punct (,3A
R8810 T10260 T10261 compound Figure,3A
R8811 T10261 T10258 appos 3A,phosphorylation
R8812 T10262 T10258 punct ),phosphorylation
R8813 T10263 T10258 cc and,phosphorylation
R8814 T10264 T10258 conj activity,phosphorylation
R8815 T10265 T10255 conj measured,decreased
R8816 T10266 T10265 agent by,measured
R8817 T10267 T10266 pobj phosphorylation,by
R8818 T10268 T10267 prep of,phosphorylation
R8819 T10269 T10271 det the,target
R8820 T10270 T10271 amod downstream,target
R8821 T10271 T10268 pobj target,of
R8822 T10272 T10271 appos ATF-2,target
R8823 T10273 T10275 punct (,3B
R8824 T10274 T10275 compound Figure,3B
R8825 T10275 T10272 appos 3B,ATF-2
R8826 T10276 T10272 punct ),ATF-2
R8827 T10277 T10255 punct .,decreased
R8828 T10278 T10279 det This,effect
R8829 T10279 T10281 nsubjpass effect,detected
R8830 T10280 T10281 auxpass was,detected
R8831 T10281 T10281 ROOT detected,detected
R8832 T10282 T10281 prep at,detected
R8833 T10283 T10284 nummod 30,min
R8834 T10284 T10282 pobj min,at
R8835 T10285 T10281 cc and,detected
R8836 T10286 T10281 conj lasted,detected
R8837 T10287 T10286 prep for,lasted
R8838 T10288 T10289 advmod at,least
R8839 T10289 T10290 advmod least,14
R8840 T10290 T10291 nummod 14,h
R8841 T10291 T10287 pobj h,for
R8842 T10292 T10294 punct (,3B
R8843 T10293 T10294 compound Figure,3B
R8844 T10294 T10291 appos 3B,h
R8845 T10295 T10291 punct ),h
R8846 T10296 T10281 punct .,detected
R8847 T10297 T10306 nsubj FP,reduced
R8848 T10298 T10300 punct (,−
R8849 T10299 T10300 nummod 10,−
R8850 T10300 T10306 nsubj −,reduced
R8851 T10301 T10300 nummod 8,−
R8852 T10302 T10300 appos M,−
R8853 T10303 T10300 punct ),−
R8854 T10304 T10306 advmod also,reduced
R8855 T10305 T10306 advmod significantly,reduced
R8856 T10306 T10306 ROOT reduced,reduced
R8857 T10307 T10309 nmod GATA-3,phosphorylation
R8858 T10308 T10309 compound serine,phosphorylation
R8859 T10309 T10306 dobj phosphorylation,reduced
R8860 T10310 T10309 acl induced,phosphorylation
R8861 T10311 T10310 agent by,induced
R8862 T10312 T10315 amod anti-CD3,stimulation
R8863 T10313 T10315 nmod /,stimulation
R8864 T10314 T10315 nummod CD28,stimulation
R8865 T10315 T10311 pobj stimulation,by
R8866 T10316 T10315 prep in,stimulation
R8867 T10317 T10319 preconj both,time
R8868 T10318 T10319 det a,time
R8869 T10319 T10316 pobj time,in
R8870 T10320 T10319 punct -,time
R8871 T10321 T10319 cc and,time
R8872 T10322 T10323 amod concentration-dependent,manner
R8873 T10323 T10319 conj manner,time
R8874 T10324 T10326 punct (,3C
R8875 T10325 T10326 compound Figure,3C
R8876 T10326 T10323 appos 3C,manner
R8877 T10327 T10326 punct ),3C
R8878 T10328 T10306 punct .,reduced
R8879 T10329 T10330 det This,reduction
R8880 T10330 T10336 nsubjpass reduction,seen
R8881 T10331 T10330 prep in,reduction
R8882 T10332 T10333 amod GATA-3,phosphorylation
R8883 T10333 T10331 pobj phosphorylation,in
R8884 T10334 T10336 auxpass was,seen
R8885 T10335 T10336 advmod also,seen
R8886 T10336 T10336 ROOT seen,seen
R8887 T10337 T10336 prep with,seen
R8888 T10338 T10339 amod lower,concentrations
R8889 T10339 T10337 pobj concentrations,with
R8890 T10340 T10339 prep of,concentrations
R8891 T10341 T10340 pobj FP,of
R8892 T10342 T10336 punct .,seen
R8893 T10343 T10344 nsubj We,found
R8894 T10344 T10344 ROOT found,found
R8895 T10345 T10348 mark that,induced
R8896 T10346 T10348 nsubj FP,induced
R8897 T10347 T10348 advmod significantly,induced
R8898 T10348 T10344 ccomp induced,found
R8899 T10349 T10350 compound MKP-1,mRNA
R8900 T10350 T10348 dobj mRNA,induced
R8901 T10351 T10348 prep in,induced
R8902 T10352 T10354 predet both,time
R8903 T10353 T10354 det a,time
R8904 T10354 T10351 pobj time,in
R8905 T10355 T10348 punct -,induced
R8906 T10356 T10348 cc and,induced
R8907 T10357 T10358 amod concentration-dependent,manner
R8908 T10358 T10348 conj manner,induced
R8909 T10359 T10358 punct ",",manner
R8910 T10360 T10358 acl reaching,manner
R8911 T10361 T10362 det a,plateau
R8912 T10362 T10360 dobj plateau,reaching
R8913 T10363 T10360 prep at,reaching
R8914 T10364 T10365 nummod 10,−
R8915 T10365 T10367 compound −,M
R8916 T10366 T10367 compound 8,M
R8917 T10367 T10363 pobj M,at
R8918 T10368 T10360 prep after,reaching
R8919 T10369 T10370 nummod 10,min
R8920 T10370 T10368 pobj min,after
R8921 T10371 T10372 punct (,Figure
R8922 T10372 T10376 nmod Figure,)
R8923 T10373 T10372 nummod 3D,Figure
R8924 T10374 T10372 cc and,Figure
R8925 T10375 T10372 conj 3E,Figure
R8926 T10376 T10358 punct ),manner
R8927 T10377 T10344 punct .,found
R8928 T10378 T10396 advmod However,seen
R8929 T10379 T10396 punct ",",seen
R8930 T10380 T10381 det the,effects
R8931 T10381 T10396 nsubjpass effects,seen
R8932 T10382 T10381 prep of,effects
R8933 T10383 T10382 pobj FP,of
R8934 T10384 T10381 prep on,effects
R8935 T10385 T10387 nmod GATA-3,import
R8936 T10386 T10387 amod nuclear,import
R8937 T10387 T10384 pobj import,on
R8938 T10388 T10387 punct ",",import
R8939 T10389 T10390 amod importin-α,association
R8940 T10390 T10387 conj association,import
R8941 T10391 T10390 cc and,association
R8942 T10392 T10390 conj IL-4,association
R8943 T10393 T10394 compound mRNA,expression
R8944 T10394 T10390 conj expression,association
R8945 T10395 T10396 auxpass are,seen
R8946 T10396 T10396 ROOT seen,seen
R8947 T10397 T10396 prep at,seen
R8948 T10398 T10400 nummod "10,000-fold",concentrations
R8949 T10399 T10400 amod lower,concentrations
R8950 T10400 T10397 pobj concentrations,at
R8951 T10401 T10400 punct (,concentrations
R8952 T10402 T10403 nummod 10,−
R8953 T10403 T10400 appos −,concentrations
R8954 T10404 T10405 nummod 12,M
R8955 T10405 T10403 appos M,−
R8956 T10406 T10403 punct ",",−
R8957 T10407 T10408 compound see,Figure
R8958 T10408 T10400 appos Figure,concentrations
R8959 T10409 T10408 nummod 2,Figure
R8960 T10410 T10408 punct ),Figure
R8961 T10411 T10396 punct .,seen
R8962 T10412 T10434 advcl Using,demonstrated
R8963 T10413 T10417 det an,assay
R8964 T10414 T10417 nmod in,assay
R8965 T10415 T10416 amod vitro,competition
R8966 T10416 T10417 compound competition,assay
R8967 T10417 T10412 dobj assay,Using
R8968 T10418 T10420 punct (,4A
R8969 T10419 T10420 compound Figure,4A
R8970 T10420 T10417 appos 4A,assay
R8971 T10421 T10420 punct ),4A
R8989 T10439 T10434 conj increased,demonstrated
R8990 T10440 T10441 amod GR-importin-α,association
R8991 T10441 T10439 dobj association,increased
R8992 T10442 T10439 prep in,increased
R8993 T10443 T10444 det the,presence
R8994 T10444 T10442 pobj presence,in
R8995 T10445 T10444 cc and,presence
R8996 T10446 T10444 conj absence,presence
R8997 T10447 T10446 prep of,absence
R8998 T10448 T10449 amod activated,GATA-3
R8999 T10449 T10447 pobj GATA-3,of
R9000 T10450 T10452 punct (,4B
R9001 T10451 T10452 compound Figure,4B
R9002 T10452 T10449 appos 4B,GATA-3
R9003 T10453 T10449 punct ),GATA-3
R9004 T10454 T10439 punct .,increased
R9005 T10455 T10456 det This,effect
R9006 T10456 T10457 nsubj effect,is
R9007 T10457 T10457 ROOT is,is
R9008 T10458 T10457 neg not,is
R9009 T10459 T10457 acomp mutual,is
R9010 T10460 T10457 punct ",",is
R9011 T10461 T10462 mark since,activated
R9012 T10462 T10466 advcl activated,block
R9013 T10463 T10466 nsubj GATA-3,block
R9014 T10464 T10466 aux did,block
R9015 T10465 T10466 neg not,block
R9016 T10466 T10457 advcl block,is
R9017 T10467 T10466 dobj GR,block
R9018 T10468 T10469 amod importin-α,association
R9019 T10469 T10466 dep association,block
R9020 T10470 T10471 punct (,Figure
R9021 T10471 T10472 nmod Figure,4C
R9022 T10472 T10469 appos 4C,association
R9023 T10473 T10469 punct ),association
R9024 T10474 T10457 punct .,is
R9025 T10475 T10476 det These,data
R9026 T10476 T10478 nsubj data,suggest
R9027 T10477 T10478 advmod also,suggest
R9028 T10478 T10478 ROOT suggest,suggest
R9029 T10479 T10481 mark that,activated
R9030 T10480 T10481 nsubj both,activated
R9031 T10481 T10478 ccomp activated,suggest
R9032 T10482 T10481 dobj GR,activated
R9033 T10483 T10482 cc and,GR
R9034 T10484 T10482 conj phospho-GATA-3,GR
R9035 T10485 T10487 aux can,associate
R9036 T10486 T10487 advmod directly,associate
R9037 T10487 T10478 ccomp associate,suggest
R9038 T10488 T10487 prep with,associate
R9039 T10489 T10488 pobj importin-α,with
R9040 T10490 T10492 punct (,4D
R9041 T10491 T10492 compound Figure,4D
R9042 T10492 T10489 appos 4D,importin-α
R9043 T10493 T10492 punct ),4D
R9044 T10494 T10487 cc and,associate
R9045 T10495 T10496 nsubj that,activated
R9046 T10496 T10487 conj activated,associate
R9047 T10497 T10498 compound GR,attenuates
R9048 T10498 T10498 ROOT attenuates,attenuates
R9049 T10499 T10503 det the,interaction
R9050 T10500 T10503 amod phospho-GATA-3,interaction
R9051 T10501 T10503 nmod /,interaction
R9052 T10502 T10503 amod importin-α,interaction
R9053 T10503 T10498 dobj interaction,attenuates
R9054 T10504 T10498 prep in,attenuates
R9055 T10505 T10507 det a,manner
R9056 T10506 T10507 amod concentration-dependent,manner
R9057 T10507 T10504 pobj manner,in
R9058 T10508 T10509 punct (,Figure
R9059 T10509 T10498 appos Figure,attenuates
R9060 T10510 T10509 nummod 4E,Figure
R9061 T10511 T10509 punct ),Figure
R9062 T10512 T10478 punct .,suggest
R9063 T10513 T10516 advmod Together,suggests
R9064 T10514 T10516 punct ",",suggests
R9065 T10515 T10516 nsubj this,suggests
R9066 T10516 T10516 ROOT suggests,suggests
R9067 T10517 T10521 mark that,compete
R9068 T10518 T10519 compound ligand-activated,GR
R9069 T10519 T10521 nsubj GR,compete
R9070 T10520 T10521 aux may,compete
R9071 T10521 T10516 ccomp compete,suggests
R9072 T10522 T10521 prep with,compete
R9073 T10523 T10522 pobj phospho-GATA-3,with
R9074 T10524 T10523 prep for,phospho-GATA-3
R9075 T10525 T10524 pobj importin-α,for
R9076 T10526 T10525 cc and,importin-α
R9077 T10527 T10528 advmod thereby,limit
R9078 T10528 T10525 conj limit,importin-α
R9079 T10529 T10531 amod GATA-3,import
R9080 T10530 T10531 amod nuclear,import
R9081 T10531 T10528 dobj import,limit
R9082 T10532 T10516 punct .,suggests
R9083 T10533 T10535 amod Other,interpretations
R9084 T10534 T10535 amod possible,interpretations
R9085 T10535 T10540 nsubj interpretations,include
R9086 T10536 T10535 prep of,interpretations
R9087 T10537 T10538 poss our,results
R9088 T10538 T10536 pobj results,of
R9089 T10539 T10540 aux could,include
R9090 T10540 T10540 ROOT include,include
R9091 T10541 T10542 det an,effect
R9092 T10542 T10540 dobj effect,include
R9093 T10543 T10542 prep of,effect
R9094 T10544 T10543 pobj FP,of
R9095 T10545 T10542 prep on,effect
R9096 T10546 T10548 nmod GATA-3,export
R9097 T10547 T10548 amod nuclear,export
R9098 T10548 T10545 pobj export,on
R9099 T10549 T10548 cc and/or,export
R9100 T10550 T10548 conj degradation,export
R9101 T10551 T10540 punct .,include
R9102 T10552 T10553 compound Leptomycin,B
R9103 T10553 T10562 nsubj B,affect
R9104 T10554 T10553 punct ",",B
R9105 T10555 T10556 nsubj which,inhibits
R9106 T10556 T10553 relcl inhibits,B
R9107 T10557 T10558 amod nuclear,export
R9108 T10558 T10556 dobj export,inhibits
R9109 T10559 T10562 punct ",",affect
R9110 T10560 T10562 aux did,affect
R9111 T10561 T10562 neg not,affect
R9112 T10562 T10562 ROOT affect,affect
R9113 T10563 T10564 det the,ability
R9114 T10564 T10562 dobj ability,affect
R9115 T10565 T10564 prep of,ability
R9116 T10566 T10565 pobj FP,of
R9117 T10567 T10568 aux to,block
R9118 T10568 T10564 acl block,ability
R9119 T10569 T10571 amod GATA-3,localization
R9120 T10570 T10571 amod nuclear,localization
R9121 T10571 T10568 dobj localization,block
R9122 T10572 T10574 punct (,5A
R9123 T10573 T10574 compound Figure,5A
R9124 T10574 T10571 appos 5A,localization
R9125 T10575 T10574 punct ),5A
R9126 T10576 T10562 punct .,affect
R9127 T10577 T10580 advmod Additionally,had
R9128 T10578 T10580 punct ",",had
R9129 T10579 T10580 nsubj FP,had
R9130 T10580 T10580 ROOT had,had
R9131 T10581 T10582 det no,effect
R9132 T10582 T10580 dobj effect,had
R9133 T10583 T10582 prep on,effect
R9134 T10584 T10587 amod whole,expression
R9135 T10585 T10586 compound cell,GATA-3
R9136 T10586 T10587 compound GATA-3,expression
R9137 T10587 T10583 pobj expression,on
R9138 T10588 T10580 prep during,had
R9139 T10589 T10591 det the,course
R9140 T10590 T10591 compound time,course
R9141 T10591 T10588 pobj course,during
R9142 T10592 T10591 prep of,course
R9143 T10593 T10594 det these,experiments
R9144 T10594 T10592 pobj experiments,of
R9145 T10595 T10597 punct (,5B
R9146 T10596 T10597 compound Figure,5B
R9147 T10597 T10594 appos 5B,experiments
R9148 T10598 T10597 punct ),5B
R9149 T10599 T10580 punct .,had
R9150 T10600 T10602 cc Nor,addition
R9151 T10601 T10602 aux did,addition
R9152 T10602 T10602 ROOT addition,addition
R9153 T10603 T10602 prep of,addition
R9154 T10604 T10603 pobj FP,of
R9155 T10605 T10602 advmod subsequent,addition
R9156 T10606 T10607 aux to,anti-CD3
R9157 T10607 T10605 xcomp anti-CD3,subsequent
R9158 T10608 T10611 nmod /,translocation
R9159 T10609 T10608 nummod CD28,/
R9160 T10610 T10611 amod nuclear,translocation
R9161 T10611 T10612 nsubj translocation,affect
R9162 T10612 T10607 conj affect,anti-CD3
R9163 T10613 T10615 nmod GATA-3,residency
R9164 T10614 T10615 amod nuclear,residency
R9165 T10615 T10612 dobj residency,affect
R9166 T10616 T10618 punct (,5C
R9167 T10617 T10618 compound Figure,5C
R9168 T10618 T10615 appos 5C,residency
R9169 T10619 T10615 punct ),residency
R9170 T10620 T10605 punct ",",subsequent
R9171 T10621 T10605 advcl suggesting,subsequent
R9172 T10622 T10627 mark that,enhance
R9173 T10623 T10624 amod activated,GR
R9174 T10624 T10627 nsubj GR,enhance
R9175 T10625 T10627 aux does,enhance
R9176 T10626 T10627 neg not,enhance
R9177 T10627 T10621 ccomp enhance,suggesting
R9178 T10628 T10630 amod GATA-3,export
R9179 T10629 T10630 amod nuclear,export
R9180 T10630 T10627 dobj export,enhance
R9181 T10631 T10605 punct .,subsequent
R9182 T10632 T10642 advmod Finally,was
R9183 T10633 T10642 punct ",",was
R9184 T10634 T10635 det the,effect
R9185 T10635 T10642 nsubj effect,was
R9186 T10636 T10635 prep of,effect
R9187 T10637 T10636 pobj FP,of
R9188 T10638 T10635 prep on,effect
R9189 T10639 T10641 nmod GATA-3,import
R9190 T10640 T10641 amod nuclear,import
R9191 T10641 T10638 pobj import,on
R9192 T10642 T10642 ROOT was,was
R9193 T10643 T10642 neg not,was
R9194 T10644 T10642 acomp nonspecific,was
R9195 T10645 T10642 punct ",",was
R9196 T10646 T10654 mark since,had
R9197 T10647 T10652 nmod FP,M
R9198 T10648 T10650 punct (,−
R9199 T10649 T10650 nummod 10,−
R9200 T10650 T10652 nmod −,M
R9201 T10651 T10650 nummod 8,−
R9202 T10652 T10646 pobj M,since
R9203 T10653 T10654 punct ),had
R9204 T10654 T10642 advcl had,was
R9205 T10655 T10656 det no,effect
R9206 T10656 T10654 dobj effect,had
R9207 T10657 T10656 prep on,effect
R10256 T11943 T11944 nmod ex,vivo
R10257 T11944 T11945 nsubj vivo,demonstrated
R10258 T11945 T11945 ROOT demonstrated,demonstrated
R10259 T11946 T11948 det a,decrease
R10260 T11947 T11948 amod concentration-dependent,decrease
R10261 T11948 T11945 dobj decrease,demonstrated
R10262 T11949 T11948 prep in,decrease
R10263 T11950 T11952 det the,interaction
R10264 T11951 T11952 amod direct,interaction
R10265 T11952 T11949 pobj interaction,in
R10266 T11953 T11952 prep between,interaction
R10267 T11954 T11953 pobj phospho-GATA-3,between
R10268 T11955 T11954 cc and,phospho-GATA-3
R10269 T11956 T11954 conj importin-α,phospho-GATA-3
R10270 T11957 T11956 prep in,importin-α
R10271 T11958 T11957 pobj PBMCs,in
R10272 T11959 T11954 prep from,phospho-GATA-3
R10273 T11960 T11959 pobj patients,from
R10274 T11961 T11960 prep with,patients
R10275 T11962 T11965 compound asthma,6A
R10276 T11963 T11964 punct (,Figure
R10277 T11964 T11965 compound Figure,6A
R10278 T11965 T11961 pobj 6A,with
R10279 T11966 T11965 cc and,6A
R10280 T11967 T11965 conj 6B,6A
R10281 T11968 T11967 punct ),6B
R10282 T11969 T11965 punct ",",6A
R10283 T11970 T11973 nsubjpass which,inhibited
R10284 T11971 T11973 auxpass was,inhibited
R10285 T11972 T11973 advmod significantly,inhibited
R10286 T11973 T11960 relcl inhibited,patients
R10287 T11974 T11973 prep at,inhibited
R10288 T11975 T11979 nummod 10,FP
R10289 T11976 T11979 nummod −,FP
R10290 T11977 T11979 nummod 12,FP
R10291 T11978 T11979 compound M,FP
R10292 T11979 T11974 pobj FP,at
R10293 T11980 T11979 punct (,FP
R10294 T11981 T11982 nmod p,<
R10295 T11982 T11983 nmod <,0.001
R10296 T11983 T11979 appos 0.001,FP
R10297 T11984 T11983 punct ",",0.001
R10298 T11985 T11983 conj ANOVA,0.001
R10299 T11986 T11985 cc and,ANOVA
R10300 T11987 T11988 compound Newman-Keuls,test
R10301 T11988 T11985 conj test,ANOVA
R10302 T11989 T11988 punct ),test
R10303 T11990 T11973 cc and,inhibited
R10304 T11991 T11992 advmod completely,attenuated
R10305 T11992 T11973 conj attenuated,inhibited
R10306 T11993 T11992 prep by,attenuated
R10307 T11994 T11998 nummod 10,FP
R10308 T11995 T11996 quantmod −,8
R10309 T11996 T11998 nummod 8,FP
R10310 T11997 T11998 compound M,FP
R10311 T11998 T12001 nmod FP,<
R10312 T11999 T12001 punct (,<
R10313 T12000 T12001 nmod p,<
R10314 T12001 T11993 pobj <,by
R10315 T12002 T12001 appos 0.001,<
R10316 T12003 T12001 punct ",",<
R10317 T12004 T12001 conj ANOVA,<
R10318 T12005 T12004 cc and,ANOVA
R10319 T12006 T12007 compound Newman-Keuls,test
R10320 T12007 T12004 conj test,ANOVA
R10321 T12008 T12001 punct ),<
R10322 T12009 T11945 punct .,demonstrated
R10323 T12010 T12015 poss Our,studies
R10324 T12011 T12015 amod previous,studies
R10325 T12012 T12015 compound T,studies
R10326 T12013 T12014 compound cell,line
R10327 T12014 T12015 compound line,studies
R10328 T12015 T12016 nsubj studies,indicated
R10329 T12016 T12016 ROOT indicated,indicated
R10330 T12017 T12023 mark that,suppresses
R10331 T12018 T12023 nsubj 10,suppresses
R10332 T12019 T12023 dep −,suppresses
R10333 T12020 T12023 dep 12,suppresses
R10334 T12021 T12022 compound M,FP
R10350 T12037 T12038 punct (,see
R10351 T12038 T12016 parataxis see,indicated
R10352 T12039 T12038 npadvmod Figures,see
R10353 T12040 T12043 nmod 1D,)
R10354 T12041 T12040 cc and,1D
R10355 T12042 T12040 conj 2,1D
R10356 T12043 T12038 punct ),see
R10357 T12044 T12016 punct .,indicated
R10358 T12045 T12046 det This,concentration
R10359 T12046 T12047 nsubj concentration,is
R10360 T12047 T12047 ROOT is,is
R10361 T12048 T12047 acomp close,is
R10362 T12049 T12050 aux to,peak
R10363 T12050 T12047 xcomp peak,is
R10364 T12051 T12052 compound plasma,levels
R10365 T12052 T12050 dobj levels,peak
R10366 T12053 T12052 acl obtained,levels
R10367 T12054 T12053 prep from,obtained
R10368 T12055 T12056 amod asthmatic,patients
R10369 T12056 T12054 pobj patients,from
R10370 T12057 T12056 acl treated,patients
R10371 T12058 T12057 prep with,treated
R10372 T12059 T12060 amod inhaled,FP
R10373 T12060 T12065 nmod FP,[
R10374 T12061 T12060 punct (,FP
R10375 T12062 T12063 nummod 500,µg
R10376 T12063 T12060 appos µg,FP
R10377 T12064 T12065 punct ),[
R10378 T12065 T12067 nmod [,]
R10379 T12066 T12067 nummod 27,]
R10380 T12067 T12058 pobj ],with
R10381 T12068 T12047 punct .,is
R10382 T12069 T12070 compound Inhaled,FP
R10383 T12070 T12082 nsubj FP,reduced
R10384 T12071 T12073 punct (,µg
R10385 T12072 T12073 nummod 500,µg
R10386 T12073 T12070 appos µg,FP
R10387 T12074 T12073 punct ),µg
R10388 T12075 T12070 appos treatment,FP
R10389 T12076 T12075 prep of,treatment
R10390 T12077 T12080 nummod seven,patients
R10391 T12078 T12080 amod steroid-naive,patients
R10392 T12079 T12080 compound asthma,patients
R10393 T12080 T12076 pobj patients,of
R10394 T12081 T12082 advmod significantly,reduced
R10395 T12082 T12082 ROOT reduced,reduced
R10396 T12083 T12082 dobj GATA-3,reduced
R10397 T12084 T12085 amod importin-α,interaction
R10398 T12085 T12083 appos interaction,GATA-3
R10399 T12086 T12085 prep in,interaction
R10400 T12087 T12086 pobj vivo,in
R10401 T12088 T12082 prep in,reduced
R10402 T12089 T12091 det a,manner
R10403 T12090 T12091 amod time-dependent,manner
R10404 T12091 T12088 pobj manner,in
R10405 T12092 T12082 punct .,reduced
R10406 T12093 T12094 nsubj This,produced
R10407 T12094 T12094 ROOT produced,produced
R10408 T12095 T12096 det a,>
R10409 T12096 T12099 compound >,decrease
R10410 T12097 T12098 nummod 90,%
R10411 T12098 T12099 compound %,decrease
R10412 T12099 T12094 dobj decrease,produced
R10413 T12100 T12099 prep in,decrease
R10414 T12101 T12100 pobj GATA-3,in
R10415 T12102 T12103 compound importin-α,association
R10416 T12103 T12099 appos association,decrease
R10417 T12104 T12099 prep at,decrease
R10418 T12105 T12106 nummod 2,h
R10419 T12106 T12104 pobj h,at
R10420 T12107 T12113 punct (,]
R10421 T12108 T12113 amod median,]
R10422 T12109 T12113 compound [,]
R10423 T12110 T12111 nummod 95,%
R10424 T12111 T12113 compound %,]
R10425 T12112 T12113 compound CI,]
R10426 T12113 T12099 appos ],decrease
R10427 T12114 T12113 punct ",",]
R10428 T12115 T12117 nummod "13,494","6,828"
R10429 T12116 T12117 compound [,"6,828"
R10430 T12117 T12113 appos "6,828",]
R10431 T12118 T12119 compound "17,829",]
R10432 T12119 T12113 conj ],]
R10433 T12120 T12119 cc versus,]
R10434 T12121 T12127 dep 879,p
R10435 T12122 T12127 ccomp [,p
R10436 T12123 T12122 nummod 597,[
R10437 T12124 T12122 nummod "1,165",[
R10438 T12125 T12125 ROOT ],]
R10439 T12126 T12127 punct ;,p
R10440 T12127 T12113 parataxis p,]
R10441 T12128 T12127 advmod <,p
R10442 T12129 T12132 nummod 0.05,analysis
R10443 T12130 T12132 poss Friedman,analysis
R10444 T12131 T12130 case 's,Friedman
R10445 T12132 T12128 appos analysis,<
R10446 T12133 T12128 punct ),<
R10447 T12134 T12127 punct .,p
R10448 T12135 T12140 advmod However,reach
R10449 T12136 T12140 punct ",",reach
R10475 T12162 T12163 auxpass were,observed
R10476 T12163 T12163 ROOT observed,observed
R10477 T12164 T12169 advmod when,measured
R10478 T12165 T12169 nsubjpass GATA-3,measured
R10479 T12166 T12167 amod importin-α,association
R10480 T12167 T12165 appos association,GATA-3
R10481 T12168 T12169 auxpass was,measured
R10482 T12169 T12163 advcl measured,observed
R10483 T12170 T12172 punct (,6C
R10484 T12171 T12172 compound Figure,6C
R10485 T12172 T12169 dobj 6C,measured
R10486 T12173 T12172 cc and,6C
R10487 T12174 T12172 conj 6D,6C
R10488 T12175 T12172 punct ),6C
R10489 T12176 T12163 punct .,observed
R10490 T12177 T12179 det The,dose
R10491 T12178 T12179 amod lower,dose
R10492 T12179 T12186 nsubj dose,was
R10493 T12180 T12179 prep of,dose
R10494 T12181 T12180 pobj FP,of
R10495 T12182 T12181 punct (,FP
R10496 T12183 T12184 nummod 100,µg
R10497 T12184 T12181 appos µg,FP
R10498 T12185 T12184 punct ),µg
R10499 T12186 T12186 ROOT was,was
R10500 T12187 T12186 neg not,was
R10501 T12188 T12186 acomp effective,was
R10502 T12189 T12186 punct .,was
R10503 T12190 T12192 det The,interaction
R10504 T12191 T12192 amod attenuated,interaction
R10554 T12241 T12242 compound T,cells
R10555 T12242 T12238 pobj cells,in
R10556 T12243 T12228 punct .,examined
R10557 T12244 T12256 nsubj Treatment,increased
R10558 T12245 T12244 prep with,Treatment
R10559 T12246 T12247 amod inhaled,FP
R10560 T12247 T12245 pobj FP,with
R10561 T12248 T12247 punct (,FP
R10562 T12249 T12250 nummod 500,µg
R10563 T12250 T12247 appos µg,FP
R10564 T12251 T12244 punct ),Treatment
R10565 T12252 T12244 prep for,Treatment
R10566 T12253 T12254 nummod 2,h
R10567 T12254 T12252 pobj h,for
R10568 T12255 T12256 advmod significantly,increased
R10569 T12256 T12256 ROOT increased,increased
R10570 T12257 T12259 nmod GR,translocation
R10571 T12258 T12259 amod nuclear,translocation
R10572 T12259 T12256 dobj translocation,increased
R10573 T12260 T12262 punct (,7A
R10574 T12261 T12262 compound Figure,7A
R10575 T12262 T12259 appos 7A,translocation
R10576 T12263 T12262 punct ),7A
R10577 T12264 T12256 cc and,increased
R10578 T12265 T12266 advmod concomitantly,decreased
R10579 T12266 T12256 conj decreased,increased
R10580 T12267 T12268 det the,number
R10581 T12268 T12266 dobj number,decreased
R10582 T12269 T12268 prep of,number
R10583 T12270 T12276 amod nuclear,cells
R10585 T12272 T12276 amod immunoreactive,cells
R10586 T12273 T12276 amod peripheral,cells
R10587 T12274 T12276 compound blood,cells
R10588 T12275 T12276 compound T,cells
R10589 T12276 T12269 pobj cells,of
R10590 T12277 T12276 punct (,cells
R10591 T12278 T12279 nummod 37,%
R10592 T12279 T12276 appos %,cells
R10593 T12280 T12290 nummod ±,p
R10594 T12281 T12282 nummod 4.2,%
R10595 T12282 T12280 quantmod %,±
R10596 T12283 T12280 cc versus,±
R10597 T12284 T12285 nummod 58.2,%
R10598 T12285 T12290 dep %,p
R10599 T12286 T12288 nummod ±,%
R10600 T12287 T12288 nummod 4.95,%
R10601 T12288 T12285 appos %,%
R10602 T12289 T12290 punct ",",p
R10603 T12290 T12276 parataxis p,cells
R10604 T12291 T12292 punct =,0.016
R10605 T12292 T12290 prep 0.016,p
R10606 T12293 T12303 punct ",",compared
R10607 T12294 T12303 nsubj W,compared
R10608 T12295 T12294 punct =,W
R10609 T12296 T12294 appos 28.0,W
R10610 T12297 T12294 punct ",",W
R10611 T12298 T12301 poss Wilcoxon,test
R10612 T12299 T12298 case 's,Wilcoxon
R10613 T12300 T12301 compound rank,test
R10614 T12301 T12294 appos test,W
R10615 T12302 T12294 punct ),W
R10616 T12303 T12256 prep compared,increased
R10617 T12304 T12303 prep with,compared
R10618 T12305 T12304 pobj placebo,with
R10619 T12306 T12307 mark as,measured
R10620 T12307 T12303 advcl measured,compared
R10621 T12308 T12307 agent by,measured
R10622 T12309 T12308 pobj immunocytochemistry,by
R10623 T12310 T12312 punct (,7A
R10624 T12311 T12312 compound Figure,7A
R10625 T12312 T12309 appos 7A,immunocytochemistry
R10626 T12313 T12312 cc and,7A
R10627 T12314 T12312 conj 7B,7A
R10628 T12315 T12312 punct ),7A
R10629 T12316 T12303 punct .,compared
R10630 T12317 T12319 nsubjpass This,confirmed
R10631 T12318 T12319 auxpass was,confirmed
R10632 T12319 T12319 ROOT confirmed,confirmed
R10633 T12320 T12319 agent by,confirmed
R10634 T12321 T12322 amod Western,blotting
R10635 T12322 T12320 pobj blotting,by
R10636 T12323 T12322 punct ",",blotting
R10637 T12324 T12326 nsubj which,indicated
R10638 T12325 T12326 advmod also,indicated
R10639 T12326 T12319 ccomp indicated,confirmed
R10640 T12327 T12330 mark that,was
R10641 T12328 T12329 det this,effect
R10642 T12329 T12330 nsubj effect,was
R10643 T12330 T12326 ccomp was,indicated
R10644 T12331 T12332 preconj both,time
R10645 T12332 T12330 attr time,was
R10646 T12333 T12332 punct -,time
R10647 T12334 T12332 cc and,time
R10648 T12335 T12332 conj dose-dependent,time
R10649 T12336 T12338 punct (,7C
R10650 T12337 T12338 compound Figure,7C
R10651 T12338 T12335 appos 7C,dose-dependent
R10652 T12339 T12338 cc and,7C
R10653 T12340 T12338 conj 7D,7C
R10654 T12341 T12338 punct ),7C
R10655 T12342 T12319 punct .,confirmed
R10656 T12343 T12345 advmod Thus,inhaled
R10657 T12344 T12345 punct ",",inhaled
R10658 T12345 T12345 ROOT inhaled,inhaled
R10659 T12346 T12345 dobj FP,inhaled
R10660 T12347 T12346 punct (,FP
R10666 T12353 T12351 dobj loss,induced
R10667 T12354 T12351 prep in,induced
R10668 T12355 T12356 amod nuclear,GATA-3
R10669 T12356 T12354 pobj GATA-3,in
R10670 T12357 T12351 prep at,induced
R10671 T12358 T12359 nummod 2,h
R10672 T12359 T12357 pobj h,at
R10673 T12360 T12366 punct (,]
R10674 T12361 T12366 amod median,]
R10675 T12362 T12366 compound [,]
R10676 T12363 T12364 nummod 95,%
R10677 T12364 T12366 compound %,]
R10678 T12365 T12366 compound CI,]
R10679 T12366 T12381 meta ],<
R10680 T12367 T12366 punct ",",]
R10681 T12368 T12370 compound 0.40,0.27
R10682 T12369 T12370 compound [,0.27
R10683 T12370 T12366 appos 0.27,]
R10684 T12371 T12372 nummod 0.53,]
R10685 T12372 T12366 conj ],]
R10686 T12373 T12372 cc versus,]
R10687 T12374 T12376 compound 0.14,0.11
R10688 T12375 T12376 compound [,0.11
R10689 T12376 T12366 appos 0.11,]
R10690 T12377 T12378 nummod 0.19,]
R10691 T12378 T12366 appos ],]
R10692 T12379 T12378 punct ",",]
R10693 T12380 T12381 compound p,<
R10694 T12381 T12351 npadvmod <,induced
R10695 T12382 T12381 nummod 0.05,<
R10696 T12383 T12381 punct ",",<
R10697 T12384 T12400 nmod W,levels
R10698 T12385 T12384 punct =,W
R10699 T12386 T12384 appos 21.00,W
R10700 T12387 T12384 punct ",",W
R10701 T12388 T12391 poss Wilcoxon,test
R10702 T12389 T12388 case 's,Wilcoxon
R10703 T12390 T12391 compound rank,test
R10704 T12391 T12384 appos test,W
R10705 T12392 T12384 punct ),W
R10706 T12393 T12395 punct (,7C
R10707 T12394 T12395 compound Figure,7C
R10708 T12395 T12384 appos 7C,W
R10709 T12396 T12395 punct ),7C
R10710 T12397 T12384 cc and,W
R10711 T12398 T12400 amod cytoplasmic,levels
R10712 T12399 T12400 compound GATA-3,levels
R10713 T12400 T12402 nsubjpass levels,enhanced
R10714 T12401 T12402 auxpass were,enhanced
R10715 T12402 T12351 conj enhanced,induced
R10716 T12403 T12402 agent by,enhanced
R10717 T12404 T12405 amod inhaled,FP
R10718 T12405 T12403 pobj FP,by
R10719 T12406 T12402 prep in,enhanced
R10720 T12407 T12409 det a,manner
R10721 T12408 T12409 amod dose-dependent,manner
R10722 T12409 T12406 pobj manner,in
R10723 T12410 T12416 punct (,]
R10724 T12411 T12416 amod median,]
R10725 T12412 T12416 compound [,]
R10726 T12413 T12414 nummod 95,%
R10727 T12414 T12416 compound %,]
R10728 T12415 T12416 compound CI,]
R10729 T12416 T12409 appos ],manner
R10730 T12417 T12416 punct ",",]
R10731 T12418 T12420 nummod 0.0032,0.0026
R10732 T12419 T12420 compound [,0.0026
R10733 T12420 T12416 appos 0.0026,]
R10734 T12421 T12422 nummod 0.0039,]
R10735 T12422 T12416 conj ],]
R10736 T12423 T12422 cc versus,]
R10737 T12424 T12426 compound 0.658,0.592
R10738 T12425 T12426 compound [,0.592
R10739 T12426 T12416 appos 0.592,]
R10740 T12427 T12428 nummod 0.720,]
R10741 T12428 T12416 appos ],]
R10742 T12429 T12428 punct ",",]
R10743 T12430 T12431 compound p,<
R10744 T12431 T12432 compound <,0.05
R10745 T12432 T12428 appos 0.05,]
R10746 T12433 T12428 punct ",",]
R10747 T12434 T12428 amod W,]
R10748 T12435 T12416 punct =,]
R10749 T12436 T12416 punct −,]
R10750 T12437 T12416 appos 21.00,]
R10751 T12438 T12416 punct ",",]
R10752 T12439 T12442 poss Wilcoxon,test
R10753 T12440 T12439 case 's,Wilcoxon
R10754 T12441 T12442 compound rank,test
R10755 T12442 T12416 appos test,]
R10756 T12443 T12416 punct ),]
R10757 T12444 T12446 punct (,7D
R10758 T12445 T12446 compound Figure,7D
R10759 T12446 T12416 appos 7D,]
R10760 T12447 T12416 punct ),]
R10761 T12448 T12345 punct .,inhaled
R10762 T12449 T12457 prep In,inhibited
R10763 T12450 T12449 pobj addition,In
R10764 T12451 T12457 punct ",",inhibited
R10765 T12452 T12457 nsubj FP,inhibited
R10766 T12453 T12455 punct (,µg
R10767 T12454 T12455 nummod 500,µg
R10768 T12455 T12452 appos µg,FP
R10769 T12456 T12455 punct ),µg
R10770 T12457 T12457 ROOT inhibited,inhibited
R10771 T12458 T12460 nummod p38,phosphorylation
R10772 T12459 T12460 compound MAPK,phosphorylation
R10773 T12460 T12457 dobj phosphorylation,inhibited
R10774 T12461 T12460 prep in,phosphorylation
R10775 T12462 T12464 amod primary,cells
R10812 T12499 T12498 dobj phospho-GATA-3,inhibiting
R10813 T12500 T12501 compound importin,association
R10814 T12501 T12498 npadvmod association,inhibiting
R10815 T12502 T12485 punct .,suggest
R10816 T12503 T12504 det This,effect
R10817 T12504 T12506 nsubj effect,be
R10818 T12505 T12506 aux may,be
R10819 T12506 T12506 ROOT be,be
R10820 T12507 T12506 acomp direct,be
R10821 T12508 T12507 punct ",",direct
R10822 T12509 T12506 prep through,be
R10823 T12510 T12509 pobj competition,through
R10824 T12511 T12510 prep for,competition
R10825 T12512 T12515 amod importin-α,molecules
R10826 T12513 T12512 cc or,importin-α
R10827 T12514 T12512 conj associated,importin-α
R10828 T12515 T12511 pobj molecules,for
R10829 T12516 T12515 punct ",",molecules
R10830 T12517 T12510 cc or,competition
R10831 T12518 T12510 conj secondary,competition
R10832 T12519 T12518 prep to,secondary
R10833 T12520 T12521 det an,effect
R10834 T12521 T12519 pobj effect,to
R10835 T12522 T12521 prep on,effect
R10836 T12523 T12526 nummod p38,phosphorylation
R10837 T12524 T12526 nmod MAPK-mediated,phosphorylation
R10838 T12525 T12526 amod GATA-3,phosphorylation
R10839 T12526 T12522 pobj phosphorylation,on
R10840 T12527 T12506 prep via,be
R10841 T12528 T12529 amod rapid,induction
R10842 T12529 T12527 pobj induction,via
R10843 T12530 T12529 prep of,induction
R10844 T12531 T12530 pobj MKP-1,of
R10845 T12532 T12506 punct .,be
R10846 T12533 T12534 det The,combination
R10847 T12534 T12541 nsubj combination,result
R10848 T12535 T12534 prep of,combination
R10849 T12536 T12539 det these,effects
R10850 T12537 T12539 nummod two,effects
R10851 T12538 T12539 amod interacting,effects
R10852 T12539 T12535 pobj effects,of
R10853 T12540 T12541 aux can,result
R10854 T12541 T12541 ROOT result,result
R10855 T12542 T12541 prep in,result
R10856 T12543 T12544 amod complete,suppression
R10857 T12544 T12542 pobj suppression,in
R10858 T12545 T12544 prep of,suppression
R10859 T12546 T12554 amod GATA-3,expression
R10860 T12547 T12548 amod nuclear,import
R10861 T12548 T12554 nmod import,expression
R10862 T12549 T12548 cc and,import
R10863 T12550 T12554 advmod thus,expression
R10864 T12551 T12554 amod Th2,expression
R10865 T12552 T12554 amod cytokine,expression
R10866 T12553 T12554 compound gene,expression
R10867 T12554 T12545 pobj expression,of
R10868 T12555 T12541 punct .,result
R12321 T14309 T14312 advmod Here,demonstrated
R12322 T14310 T14312 nsubj we,demonstrated
R12323 T14311 T14312 aux have,demonstrated
R12324 T14312 T14312 ROOT demonstrated,demonstrated
R12325 T14313 T14312 punct ",",demonstrated
R12326 T14314 T14312 prep to,demonstrated
R12327 T14315 T14316 poss our,knowledge
R12328 T14316 T14314 pobj knowledge,to
R12329 T14317 T14316 prep for,knowledge
R12330 T14318 T14320 det the,time
R12331 T14319 T14320 amod first,time
R12332 T14320 T14317 pobj time,for
R12333 T14321 T14312 punct ",",demonstrated
R12334 T14322 T14325 mark that,inhibit
R12335 T14323 T14325 nsubj corticosteroids,inhibit
R12336 T14324 T14325 aux may,inhibit
R12337 T14325 T14312 ccomp inhibit,demonstrated
R12338 T14326 T14327 compound GATA-3,function
R12339 T14327 T14325 dobj function,inhibit
R12340 T14328 T14325 cc and,inhibit
R12341 T14329 T14331 advmod therefore,transcription
R12342 T14330 T14331 det the,transcription
R12343 T14331 T14325 conj transcription,inhibit
R12344 T14332 T14331 prep of,transcription
R12345 T14333 T14334 amod Th2,genes
R12346 T14334 T14332 pobj genes,of
R12347 T14335 T14331 prep via,transcription
R12348 T14336 T14341 nummod two,mechanisms
R12349 T14337 T14341 amod distinct,mechanisms
R12350 T14338 T14337 cc but,distinct
R12390 T14378 T14378 ROOT increase,increase
R12391 T14379 T14380 det the,expression
R12392 T14380 T14378 dobj expression,increase
R12393 T14381 T14380 prep of,expression
R12394 T14382 T14381 pobj MKP-1,of
R12395 T14383 T14382 punct ",",MKP-1
R12396 T14384 T14386 det a,inhibitor
R12397 T14385 T14386 amod potent,inhibitor
R12398 T14386 T14382 appos inhibitor,MKP-1
R12399 T14387 T14386 prep of,inhibitor
R12400 T14388 T14390 nummod p38,activity
R12401 T14389 T14390 compound MAPK,activity
R12402 T14390 T14387 pobj activity,of
R12403 T14391 T14378 cc and,increase
R12404 T14392 T14393 advmod thereby,prevent
R12405 T14393 T14378 conj prevent,increase
R12406 T14394 T14397 compound T,activation
R12407 T14395 T14396 compound cell,receptor/co-receptor
R12408 T14396 T14397 compound receptor/co-receptor,activation
R12409 T14397 T14393 dobj activation,prevent
R12410 T14398 T14397 prep of,activation
R12411 T14399 T14400 nummod p38,MAPK
R12412 T14400 T14398 pobj MAPK,of
R12413 T14401 T14402 aux to,prevent
R12414 T14402 T14393 advcl prevent,prevent
R12415 T14403 T14404 det the,phosphorylation
R12416 T14404 T14402 dobj phosphorylation,prevent
R12417 T14405 T14404 prep of,phosphorylation
R12418 T14406 T14405 pobj GATA-3,of
R12419 T14407 T14408 nsubj that,is
R12420 T14408 T14406 relcl is,GATA-3
R12421 T14409 T14408 acomp necessary,is
R12422 T14410 T14409 prep for,necessary
R12423 T14411 T14410 pobj interaction,for
R12424 T14412 T14411 prep with,interaction
R12425 T14413 T14412 pobj importin-α,with
R12426 T14414 T14413 cc and,importin-α
R12427 T14415 T14417 amod subsequent,import
R12428 T14416 T14417 amod nuclear,import
R12429 T14417 T14413 conj import,importin-α
R12458 T14446 T14447 nummod 12,]
R12459 T14447 T14445 appos ],[
R12460 T14448 T14422 punct .,shown
R12461 T14449 T14453 nsubj We,reported
R12462 T14450 T14453 aux have,reported
R12463 T14451 T14453 advmod also,reported
R12464 T14452 T14453 advmod previously,reported
R12465 T14453 T14453 ROOT reported,reported
R12466 T14454 T14466 mark that,stimulated
R12467 T14455 T14456 amod GATA-3,knockdown
R12468 T14456 T14466 nsubj knockdown,stimulated
R12469 T14457 T14456 acl using,knockdown
R12470 T14458 T14459 compound siRNA,results
R12471 T14459 T14457 dobj results,using
R12472 T14460 T14459 prep in,results
R12473 T14461 T14460 pobj suppression,in
R12474 T14462 T14461 prep of,suppression
R12475 T14463 T14464 compound anti-CD3,/
R12476 T14464 T14465 compound /,CD28
R12477 T14465 T14462 pobj CD28,of
R12478 T14466 T14453 ccomp stimulated,reported
R12479 T14467 T14469 compound IL-4,IL-5
R12480 T14468 T14469 compound /,IL-5
R12481 T14469 T14470 compound IL-5,mRNA
R12482 T14470 T14471 compound mRNA,induction
R12483 T14471 T14466 dobj induction,stimulated
R12484 T14472 T14466 punct ",",stimulated
R12485 T14473 T14474 advmod thus,implicating
R12486 T14474 T14466 prep implicating,stimulated
R12487 T14475 T14477 det an,role
R12488 T14476 T14477 amod essential,role
R12489 T14477 T14474 dobj role,implicating
R12490 T14478 T14477 prep for,role
R12491 T14479 T14478 pobj GATA-3,for
R12492 T14480 T14477 prep in,role
R12493 T14481 T14482 det the,transcription
R12494 T14482 T14480 pobj transcription,in
R12495 T14483 T14482 prep of,transcription
R12496 T14484 T14485 det these,genes
R12497 T14485 T14483 pobj genes,of
R12498 T14486 T14488 nmod [,]
R12499 T14487 T14488 nummod 12,]
R12500 T14488 T14482 appos ],transcription
R12501 T14489 T14453 punct .,reported
R12502 T14490 T14492 nsubj We,confirm
R12503 T14491 T14492 advmod now,confirm
R12504 T14492 T14492 ROOT confirm,confirm
R12505 T14493 T14492 punct ",",confirm
R12506 T14494 T14492 prep in,confirm
R12507 T14495 T14497 amod human,cells
R12508 T14496 T14497 compound T,cells
R12509 T14497 T14494 pobj cells,in
R12510 T14498 T14492 punct ",",confirm
R12511 T14499 T14502 mark that,uses
R12512 T14500 T14502 nsubj GR,uses
R12513 T14501 T14502 advmod also,uses
R12514 T14502 T14492 ccomp uses,confirm
R12515 T14503 T14507 det the,mechanism
R12516 T14504 T14507 amod same,mechanism
R12517 T14505 T14507 amod nuclear,mechanism
R12518 T14506 T14507 compound import,mechanism
R12519 T14507 T14502 dobj mechanism,uses
R12520 T14508 T14502 prep as,uses
R12521 T14509 T14510 compound GATA-3,[
R12522 T14510 T14508 pobj [,as
R12523 T14511 T14512 nummod 22,]
R12524 T14512 T14510 appos ],[
R12525 T14513 T14492 punct .,confirm
R12526 T14514 T14516 nsubj We,propose
R12527 T14515 T14516 advmod therefore,propose
R12528 T14516 T14516 ROOT propose,propose
R12529 T14517 T14519 mark that,is
R12530 T14518 T14519 expl there,is
R12531 T14519 T14516 ccomp is,propose
R12532 T14520 T14519 attr competition,is
R12533 T14521 T14520 prep between,competition
R12534 T14522 T14523 compound ligand-activated,GR
R12535 T14523 T14521 pobj GR,between
R12536 T14524 T14523 cc and,GR
R12537 T14525 T14523 conj phospho-GATA-3,GR
R12538 T14526 T14520 prep for,competition
R12539 T14527 T14528 amod nuclear,import
R12540 T14528 T14526 pobj import,for
R12541 T14529 T14516 punct .,propose
R12542 T14530 T14534 advmod Furthermore,shown
R12543 T14531 T14534 punct ",",shown
R12544 T14532 T14534 nsubj we,shown
R12545 T14533 T14534 aux have,shown
R12546 T14534 T14534 ROOT shown,shown
R12547 T14535 T14537 mark that,is
R12548 T14536 T14537 expl there,is
R12549 T14537 T14534 ccomp is,shown
R12550 T14538 T14539 amod preferential,binding
R12551 T14539 T14537 attr binding,is
R12552 T14540 T14539 prep of,binding
R12553 T14541 T14540 pobj importin-α,of
R12554 T14542 T14543 aux to,activated
R12555 T14543 T14534 xcomp activated,shown
R12556 T14544 T14543 dobj GR,activated
R12557 T14545 T14543 prep over,activated
R12558 T14546 T14545 pobj phospho-GATA-3,over
R12559 T14547 T14534 punct ",",shown
R12560 T14548 T14553 mark so,reduce
R12561 T14549 T14553 mark that,reduce
R12562 T14550 T14553 nsubj corticosteroids,reduce
R12563 T14551 T14553 aux would,reduce
R12564 T14552 T14553 advmod preferentially,reduce
R12565 T14553 T14534 advcl reduce,shown
R12566 T14554 T14555 compound GATA-3,entry
R12567 T14555 T14553 dobj entry,reduce
R12568 T14556 T14553 cc and,reduce
R12569 T14557 T14559 advmod thus,switch
R12570 T14558 T14559 advmod rapidly,switch
R12571 T14559 T14553 conj switch,reduce
R12572 T14560 T14559 prt off,switch
R12573 T14561 T14563 nummod Th2,transcription
R12574 T14562 T14563 compound gene,transcription
R12575 T14563 T14559 dobj transcription,switch
R12576 T14564 T14559 prep without,switch
R12577 T14565 T14566 det any,need
R12578 T14566 T14564 pobj need,without
R12579 T14567 T14566 prep for,need
R12580 T14568 T14570 det any,steps
R12581 T14569 T14570 amod intermediate,steps
R12582 T14570 T14567 pobj steps,for
R12583 T14571 T14534 punct .,shown
R12584 T14572 T14575 advmod Furthermore,was
R12585 T14573 T14575 punct ",",was
R12586 T14574 T14575 expl there,was
R12587 T14575 T14575 ROOT was,was
R12588 T14576 T14577 det some,degree
R12589 T14577 T14575 attr degree,was
R12590 T14578 T14577 prep of,degree
R12591 T14579 T14578 pobj specificity,of
R12592 T14580 T14577 prep for,degree
R12593 T14581 T14580 pobj GATA-3,for
R12594 T14582 T14577 punct ",",degree
R12595 T14583 T14594 mark as,affected
R12596 T14584 T14585 amod nuclear,translocation
R12597 T14585 T14583 pobj translocation,as
R12598 T14586 T14585 prep of,translocation
R12599 T14587 T14589 det the,subunit
R12600 T14588 T14589 nummod p65,subunit
R12601 T14589 T14586 pobj subunit,of
R12602 T14590 T14589 prep of,subunit
R12603 T14591 T14590 pobj NF-κB,of
R12604 T14592 T14594 auxpass was,affected
R12605 T14593 T14594 neg not,affected
R12606 T14594 T14575 advcl affected,was
R12607 T14595 T14594 agent by,affected
R12608 T14596 T14597 amod corticosteroid,exposure
R12609 T14597 T14595 pobj exposure,by
R12610 T14598 T14575 punct .,was
R12611 T14599 T14600 nsubj We,tested
R12612 T14600 T14600 ROOT tested,tested
R12613 T14601 T14603 det some,explanations
R12614 T14602 T14603 amod alternative,explanations
R12615 T14603 T14600 dobj explanations,tested
R12616 T14604 T14603 prep for,explanations
R12617 T14605 T14606 det this,effect
R12618 T14606 T14604 pobj effect,for
R12619 T14607 T14606 prep of,effect
R12620 T14608 T14607 pobj FP,of
R12621 T14609 T14606 prep on,effect
R12622 T14610 T14612 nmod GATA-3,exclusion
R12623 T14611 T14612 amod nuclear,exclusion
R12624 T14612 T14609 pobj exclusion,on
R12625 T14613 T14600 cc and,tested
R12626 T14614 T14600 conj failed,tested
R12627 T14615 T14616 aux to,show
R12628 T14616 T14614 xcomp show,failed
R12629 T14617 T14620 mark that,enhances
R12630 T14618 T14620 nsubj FP,enhances
R12631 T14619 T14620 preconj either,enhances
R12632 T14620 T14616 ccomp enhances,show
R12633 T14621 T14623 amod GATA-3,export
R12634 T14622 T14623 amod nuclear,export
R12635 T14623 T14620 dobj export,enhances
R12636 T14624 T14620 advmod directly,enhances
R12637 T14625 T14620 cc or,enhances
R12638 T14626 T14620 conj induces,enhances
R12639 T14627 T14628 amod GATA-3,degradation
R12640 T14628 T14626 dobj degradation,induces
R12641 T14629 T14600 punct .,tested
R12642 T14630 T14631 det The,evidence
R12643 T14631 T14638 nsubj evidence,does
R12644 T14632 T14631 prep from,evidence
R12645 T14633 T14638 det the,does
R12646 T14634 T14638 prep in,does
R12647 T14635 T14636 amod vitro,competition
R12648 T14636 T14637 compound competition,assays
R12649 T14637 T14634 pobj assays,in
R12650 T14638 T14642 aux does,suggest
R12651 T14639 T14642 punct ",",suggest
R12652 T14640 T14642 advmod however,suggest
R12653 T14641 T14642 punct ",",suggest
R12654 T14642 T14642 ROOT suggest,suggest
R12655 T14643 T14649 mark that,attenuate
R12656 T14644 T14646 amod purified,GR
R12657 T14645 T14646 amod activated,GR
R12658 T14646 T14649 nsubj GR,attenuate
R12659 T14647 T14649 aux can,attenuate
R12660 T14648 T14649 advmod clearly,attenuate
R12661 T14649 T14642 ccomp attenuate,suggest
R12662 T14650 T14651 amod purified,phospho-GATA-3
R12663 T14651 T14649 dobj phospho-GATA-3,attenuate
R12664 T14652 T14653 amod importin-α,association
R12665 T14653 T14651 appos association,phospho-GATA-3
R12666 T14654 T14649 cc and,attenuate
R12667 T14655 T14660 mark that,occur
R12668 T14656 T14657 det the,converse
R12669 T14657 T14660 nsubj converse,occur
R12670 T14658 T14660 aux does,occur
R12671 T14659 T14660 neg not,occur
R12672 T14660 T14649 conj occur,attenuate
R12673 T14661 T14642 punct .,suggest
R12674 T14662 T14666 advmod Furthermore,shown
R12675 T14663 T14666 punct ",",shown
R12676 T14664 T14666 nsubj we,shown
R12677 T14665 T14666 aux have,shown
R12678 T14666 T14666 ROOT shown,shown
R12679 T14667 T14671 mark that,associate
R12680 T14668 T14669 advmod only,phospho-GATA-3
R12681 T14669 T14671 nsubj phospho-GATA-3,associate
R12682 T14670 T14671 aux can,associate
R12683 T14671 T14666 ccomp associate,shown
R12684 T14672 T14671 prep with,associate
R12685 T14673 T14672 pobj importin-α,with
R12686 T14674 T14666 punct .,shown
R12687 T14675 T14676 det This,mechanism
R12688 T14676 T14677 nsubj mechanism,is
R12689 T14677 T14677 ROOT is,is
R12690 T14678 T14677 acomp sensitive,is
R12691 T14679 T14678 prep to,sensitive
R12692 T14680 T14681 advmod very,low
R12693 T14681 T14682 amod low,concentrations
R12694 T14682 T14679 pobj concentrations,to
R12695 T14683 T14682 prep of,concentrations
R12696 T14684 T14683 pobj corticosteroid,of
R12697 T14685 T14677 cc and,is
R12698 T14686 T14687 aux would,be
R12699 T14687 T14677 conj be,is
R12700 T14688 T14687 acomp rapid,be
R12701 T14689 T14688 prep in,rapid
R12702 T14690 T14689 pobj onset,in
R12703 T14691 T14698 mark as,required
R12704 T14692 T14693 det no,changes
R12705 T14693 T14698 nsubjpass changes,required
R12706 T14694 T14693 prep in,changes
R12707 T14695 T14696 compound protein,synthesis
R12741 T14729 T14728 prep to,prior
R12742 T14730 T14731 compound MKP-1,induction
R12743 T14731 T14729 pobj induction,to
R12744 T14732 T14705 punct .,contribute
R12745 T14733 T14735 nsubj Corticosteroids,modulate
R12746 T14734 T14735 aux can,modulate
R12747 T14735 T14735 ROOT modulate,modulate
R12748 T14736 T14738 nummod p38,activity
R12749 T14737 T14738 compound MAPK,activity
R12750 T14738 T14735 dobj activity,modulate
R12751 T14739 T14735 prep through,modulate
R12752 T14740 T14741 det the,induction
R12753 T14741 T14739 pobj induction,through
R12754 T14742 T14741 prep of,induction
R12755 T14743 T14742 pobj MKP-1,of
R12756 T14744 T14743 punct ",",MKP-1
R12757 T14745 T14748 det a,inhibitor
R12758 T14746 T14748 amod potent,inhibitor
R12759 T14747 T14748 amod endogenous,inhibitor
R12760 T14748 T14743 appos inhibitor,MKP-1
R12761 T14749 T14748 prep of,inhibitor
R12762 T14750 T14751 compound MAPK,function
R12763 T14751 T14749 pobj function,of
R12764 T14752 T14754 nmod [,]
R12765 T14753 T14754 nummod 38,]
R12766 T14754 T14748 appos ],inhibitor
R12767 T14755 T14754 punct ",",]
R12768 T14756 T14758 nmod [,]
R12769 T14757 T14758 nummod 39,]
R12770 T14758 T14754 appos ],]
R12771 T14759 T14735 punct .,modulate
R12772 T14760 T14761 nsubj We,report
R12773 T14761 T14761 ROOT report,report
R12774 T14762 T14761 advmod here,report
R12775 T14763 T14765 det a,induction
R12776 T14764 T14765 amod rapid,induction
R12777 T14765 T14761 dobj induction,report
R12778 T14766 T14765 prep of,induction
R12779 T14767 T14768 compound MKP-1,mRNA
R12780 T14768 T14766 pobj mRNA,of
R12781 T14769 T14765 prep following,induction
R12782 T14770 T14769 pobj stimulation,following
R12783 T14771 T14770 prep of,stimulation
R12784 T14772 T14771 pobj cells,of
R12785 T14773 T14772 prep with,cells
R12786 T14774 T14775 advmod relatively,high
R12787 T14775 T14776 amod high,concentrations
R12788 T14776 T14773 pobj concentrations,with
R12789 T14777 T14776 prep of,concentrations
R12790 T14778 T14777 pobj FP,of
R12791 T14779 T14761 punct .,report
R12792 T14780 T14781 nsubj We,hypothesize
R12793 T14781 T14781 ROOT hypothesize,hypothesize
R12794 T14782 T14789 mark that,reduce
R12795 T14783 T14785 det this,induction
R12796 T14784 T14785 amod rapid,induction
R12797 T14785 T14789 nsubj induction,reduce
R12798 T14786 T14785 prep of,induction
R12799 T14787 T14786 pobj MKP-1,of
R12800 T14788 T14789 aux can,reduce
R12801 T14789 T14781 ccomp reduce,hypothesize
R12802 T14790 T14792 amod GATA-3,import
R12803 T14791 T14792 amod nuclear,import
R12804 T14792 T14789 dobj import,reduce
R12805 T14793 T14789 prep by,reduce
R12806 T14794 T14793 pcomp attenuating,by
R12807 T14795 T14797 nummod p38,activity
R12808 T14796 T14797 compound MAPK,activity
R12809 T14797 T14794 dobj activity,attenuating
R12810 T14798 T14797 cc and,activity
R12811 T14799 T14801 amod subsequent,phosphorylation
R12812 T14800 T14801 compound GATA-3,phosphorylation
R12813 T14801 T14797 conj phosphorylation,activity
R12814 T14802 T14789 punct ",",reduce
R12815 T14803 T14804 advmod thus,preventing
R12816 T14804 T14789 advcl preventing,reduce
R12817 T14805 T14806 amod nuclear,translocation
R12818 T14806 T14804 dobj translocation,preventing
R12819 T14807 T14781 punct .,hypothesize
R12820 T14808 T14809 det The,location
R12821 T14809 T14825 nsubj location,are
R12822 T14810 T14809 prep of,location
R12823 T14811 T14813 det the,residue
R12824 T14812 T14813 compound serine,residue
R12825 T14813 T14810 pobj residue,of
R12826 T14814 T14813 punct (,residue
R12827 T14815 T14813 appos s,residue
R12828 T14816 T14813 punct ),residue
R12829 T14817 T14813 prep of,residue
R12830 T14818 T14817 pobj GATA-3,of
R12831 T14819 T14821 nsubjpass that,phosphorylated
R12832 T14820 T14821 auxpass are,phosphorylated
R12833 T14821 T14813 relcl phosphorylated,residue
R12834 T14822 T14821 agent by,phosphorylated
R12835 T14823 T14824 nummod p38,MAPK
R12836 T14824 T14822 pobj MAPK,by
R12837 T14825 T14825 ROOT are,are
R12838 T14826 T14825 advmod currently,are
R12839 T14827 T14825 acomp unknown,are
R12840 T14828 T14825 punct ",",are
R12841 T14829 T14825 cc but,are
R12842 T14830 T14832 det a,search
R12843 T14831 T14832 compound bioinformatics,search
R12844 T14832 T14839 nsubj search,indicates
R12845 T14833 T14832 punct (,search
R12846 T14834 T14835 compound Motif,Scanner
R12847 T14835 T14832 appos Scanner,search
R12848 T14836 T14835 punct ",",Scanner
R12849 T14837 T14835 appos http://scansite.mit.edu/motifscan_seq.phtml,Scanner
R12850 T14838 T14835 punct ),Scanner
R12851 T14839 T14825 conj indicates,are
R12852 T14840 T14841 advmod at,least
R12853 T14841 T14842 advmod least,three
R12854 T14842 T14847 nummod three,residues
R12855 T14843 T14847 amod potential,residues
R12856 T14844 T14847 nummod p38,residues
R12857 T14845 T14847 amod MAPK-sensitive,residues
R12858 T14846 T14847 compound serine,residues
R12859 T14847 T14839 dobj residues,indicates
R12860 T14848 T14839 punct .,indicates
R12861 T14849 T14850 mark As,predicted
R12862 T14850 T14871 advcl predicted,underlie
R12863 T14851 T14850 prep from,predicted
R12864 T14852 T14851 pobj these,from
R12865 T14853 T14850 prep in,predicted
R12866 T14854 T14855 compound vitro,data
R12867 T14855 T14853 pobj data,in
R12868 T14856 T14855 punct ",",data
R12869 T14857 T14871 nsubj impairment,underlie
R12870 T14858 T14857 prep of,impairment
R12871 T14859 T14861 amod GATA-3,import
R12872 T14860 T14861 amod nuclear,import
R12873 T14861 T14858 pobj import,of
R12874 T14862 T14857 prep by,impairment
R12875 T14863 T14862 pobj FP,by
R12876 T14864 T14871 aux may,underlie
R12877 T14865 T14871 punct ",",underlie
R12878 T14866 T14867 advmod at,least
R12879 T14867 T14868 advmod least,in
R12880 T14868 T14871 prep in,underlie
R12881 T14869 T14868 pobj part,in
R12882 T14870 T14871 punct ",",underlie
R12883 T14871 T14871 ROOT underlie,underlie
R12884 T14872 T14873 det the,efficacy
R12885 T14873 T14871 dobj efficacy,underlie
R12886 T14874 T14873 prep of,efficacy
R12887 T14875 T14874 pobj corticosteroids,of
R12888 T14876 T14871 prep in,underlie
R12889 T14877 T14876 pcomp suppressing,in
R12890 T14878 T14879 amod allergic,inflammation
R12891 T14879 T14877 dobj inflammation,suppressing
R12892 T14880 T14871 punct .,underlie
R12893 T14881 T14885 mark Although,assess
R12894 T14882 T14885 nsubj we,assess
R12895 T14883 T14885 aux did,assess
R12896 T14884 T14885 neg not,assess
R12897 T14885 T14911 advcl assess,have
R12898 T14886 T14889 det the,effect
R12899 T14887 T14889 amod acute,effect
R12900 T14888 T14889 amod inhibitory,effect
R12901 T14889 T14885 dobj effect,assess
R12902 T14890 T14889 prep of,effect
R12903 T14891 T14890 pobj FP,of
R12904 T14892 T14889 prep on,effect
R12905 T14893 T14894 det the,expression
R12906 T14894 T14892 pobj expression,on
R12907 T14895 T14894 prep of,expression
R12908 T14896 T14897 compound IL-4,mRNA
R12909 T14897 T14895 pobj mRNA,of
R12910 T14898 T14889 prep in,effect
R12911 T14899 T14898 pobj vivo,in
R12912 T14900 T14899 punct ",",vivo
R12913 T14901 T14903 det a,inhalation
R12914 T14902 T14903 amod single,inhalation
R12915 T14903 T14911 nsubj inhalation,have
R12916 T14904 T14903 prep of,inhalation
R12917 T14905 T14904 pobj FP,of
R12918 T14906 T14905 punct (,FP
R12919 T14907 T14908 nummod 500,µg
R12920 T14908 T14905 appos µg,FP
R12921 T14909 T14905 punct ),FP
R12922 T14910 T14911 aux may,have
R12923 T14911 T14911 ROOT have,have
R12924 T14912 T14913 amod comparable,effects
R12925 T14913 T14911 dobj effects,have
R12926 T14914 T14911 punct ",",have
R12927 T14915 T14917 mark as,provides
R12928 T14916 T14917 nsubj it,provides
R12929 T14917 T14911 advcl provides,have
R12930 T14918 T14919 compound plasma,levels
R12931 T14919 T14917 dobj levels,provides
R12932 T14920 T14917 prep within,provides
R12933 T14921 T14923 det a,range
R12934 T14922 T14923 amod relevant,range
R12935 T14923 T14920 pobj range,within
R12936 T14924 T14923 prep of,range
R12937 T14925 T14924 pobj concentrations,of
R12938 T14926 T14911 advcl used,have
R12939 T14927 T14928 aux to,suppress
R12940 T14928 T14926 xcomp suppress,used
R12941 T14929 T14930 compound IL-4,transcription
R12942 T14930 T14928 dobj transcription,suppress
R12943 T14931 T14928 prep in,suppress
R12944 T14932 T14931 pobj our,in
R12945 T14933 T14928 prep in,suppress
R12946 T14934 T14935 amod vitro,system
R12947 T14935 T14933 pobj system,in
R12948 T14936 T14938 nmod [,]
R12949 T14937 T14938 nummod 37,]
R12950 T14938 T14928 conj ],suppress
R12951 T14939 T14911 punct .,have
R12952 T14940 T14942 det A,dose
R12953 T14941 T14942 amod lower,dose
R12954 T14942 T14950 nsubj dose,was
R12955 T14943 T14942 prep of,dose
R12956 T14944 T14945 amod inhaled,FP
R12957 T14945 T14943 pobj FP,of
R12958 T14946 T14945 punct (,FP
R12959 T14947 T14948 nummod 100,µg
R12960 T14948 T14945 appos µg,FP
R12961 T14949 T14948 punct ),µg
R12962 T14950 T14950 ROOT was,was
R12963 T14951 T14950 neg not,was
R12964 T14952 T14950 acomp effective,was
R12965 T14953 T14950 punct ",",was
R12966 T14954 T14950 cc but,was
R12967 T14955 T14956 compound plasma,concentrations
R12968 T14956 T14958 nsubj concentrations,be
R12969 T14957 T14958 aux may,be
R12970 T14958 T14950 conj be,was
R12971 T14959 T14958 prep below,be
R12972 T14960 T14959 pobj those,below
R12973 T14961 T14960 acl required,those
R12974 T14962 T14961 prep for,required
R12975 T14963 T14964 amod GATA-3,inhibition
R12976 T14964 T14962 pobj inhibition,for
R12977 T14965 T14958 punct .,be
R12978 T14966 T14969 advmod However,is
R12979 T14967 T14969 punct ",",is
R12980 T14968 T14969 nsubj it,is
R12981 T14969 T14969 ROOT is,is
R12982 T14970 T14969 acomp likely,is
R12983 T14971 T14984 mark that,be
R12984 T14972 T14974 det the,concentrations
R12985 T14973 T14974 amod higher,concentrations
R12986 T14974 T14984 nsubj concentrations,be
R12987 T14975 T14974 prep of,concentrations
R12988 T14976 T14975 pobj FP,of
R12989 T14977 T14974 prep in,concentrations
R12990 T14978 T14979 det the,airways
R12991 T14979 T14977 pobj airways,in
R12992 T14980 T14974 prep after,concentrations
R12993 T14981 T14982 amod inhaled,administration
R12994 T14982 T14980 pobj administration,after
R12995 T14983 T14984 aux would,be
R12996 T14984 T14970 ccomp be,likely
R12997 T14985 T14984 acomp effective,be
R12998 T14986 T14985 prep in,effective
R12999 T14987 T14986 pcomp inhibiting,in
R13000 T14988 T14987 dobj GATA-3,inhibiting
R13001 T14989 T14987 prep in,inhibiting
R13002 T14990 T14991 compound airway,T
R13003 T14991 T14992 compound T,cells
R13004 T14992 T14989 pobj cells,in
R13005 T14993 T14992 prep of,cells
R13006 T14994 T14995 compound asthma,patients
R13007 T14995 T14993 pobj patients,of
R13008 T14996 T14969 punct .,is
R13009 T14997 T14998 det The,study
R13010 T14998 T15010 nsubj study,demonstrates
R13011 T14999 T14998 prep of,study
R13012 T15000 T14999 pobj PBMCs,of
R13013 T15001 T14998 prep from,study
R13014 T15002 T15003 compound asthma,patients
R13015 T15003 T15001 pobj patients,from
R13016 T15004 T14998 acl treated,study
R13017 T15005 T15004 prep with,treated
R13018 T15006 T15008 amod inhaled,therapy
R13019 T15007 T15008 amod corticosteroid,therapy
R13020 T15008 T15005 pobj therapy,with
R13021 T15009 T15010 advmod clearly,demonstrates
R13022 T15010 T15010 ROOT demonstrates,demonstrates
R13023 T15011 T15015 mark that,are
R13024 T15012 T15014 det these,mechanisms
R13025 T15013 T15014 amod molecular,mechanisms
R13026 T15014 T15015 nsubj mechanisms,are
R13027 T15015 T15010 ccomp are,demonstrates
R13028 T15016 T15015 acomp likely,are
R13029 T15017 T15019 aux to,occur
R13030 T15018 T15019 advmod also,occur
R13031 T15019 T15016 xcomp occur,likely
R13032 T15020 T15019 prep in,occur
R13033 T15021 T15020 pobj patients,in
R13034 T15022 T15021 prep at,patients
R13035 T15023 T15024 amod therapeutic,doses
R13036 T15024 T15022 pobj doses,at
R13037 T15025 T15024 prep of,doses
R13038 T15026 T15027 amod inhaled,corticosteroids
R13039 T15027 T15025 pobj corticosteroids,of
R13040 T15028 T15010 punct .,demonstrates
R13041 T15029 T15035 prep In,shown
R13042 T15030 T15029 pobj addition,In
R13043 T15031 T15035 punct ",",shown
R13044 T15032 T15033 amod previous,studies
R13045 T15033 T15035 nsubj studies,shown
R13046 T15034 T15035 aux have,shown
R13047 T15035 T15035 ROOT shown,shown
R13048 T15036 T15039 mark that,suppress
R13049 T15037 T15039 nsubj corticosteroids,suppress
R13050 T15038 T15039 aux can,suppress
R13051 T15039 T15035 ccomp suppress,shown
R13052 T15040 T15043 nmod IL-4,release
R13053 T15041 T15040 cc and,IL-4
R13054 T15042 T15043 compound IL-5,release
R13055 T15043 T15039 dobj release,suppress
R13056 T15044 T15043 prep from,release
R13057 T15045 T15047 amod peripheral,cells
R13058 T15046 T15047 compound blood,cells
R13059 T15047 T15044 pobj cells,from
R13060 T15048 T15047 prep of,cells
R13061 T15049 T15050 compound asthma,patients
R13062 T15050 T15048 pobj patients,of
R13063 T15051 T15043 prep in,release
R13064 T15052 T15051 pobj vitro,in
R13065 T15053 T15051 cc and,in
R13066 T15054 T15051 conj in,in
R13067 T15055 T15056 compound vivo,[
R13068 T15056 T15054 pobj [,in
R13069 T15057 T15058 nummod 40,]
R13070 T15058 T15056 appos ],[
R13071 T15059 T15056 appos [,[
R13072 T15060 T15061 nummod 42,]
R13073 T15061 T15056 appos ],[
R13074 T15062 T15035 punct .,shown
R13075 T15063 T15068 prep In,provide
R13076 T15064 T15063 pobj summary,In
R13077 T15065 T15068 punct ",",provide
R13078 T15066 T15067 poss our,data
R13079 T15067 T15068 nsubj data,provide
R13080 T15068 T15068 ROOT provide,provide
R13081 T15069 T15068 dobj evidence,provide
R13082 T15070 T15069 prep for,evidence
R13083 T15071 T15073 det a,action
R13084 T15072 T15073 compound novel,action
R13085 T15073 T15070 pobj action,for
R13086 T15074 T15073 prep of,action
R13087 T15075 T15074 pobj corticosteroids,of
R13088 T15076 T15069 punct :,evidence
R13089 T15077 T15069 conj suppression,evidence
R13090 T15078 T15077 prep of,suppression
R13091 T15079 T15080 amod allergic,inflammation
R13092 T15080 T15078 pobj inflammation,of
R13093 T15081 T15068 prep through,provide
R13094 T15082 T15085 det a,effect
R13095 T15083 T15085 amod rapid,effect
R13096 T15084 T15085 amod inhibitory,effect
R13097 T15085 T15081 pobj effect,through
R13098 T15086 T15085 prep on,effect
R13099 T15087 T15089 amod GATA-3,translocation
R13100 T15088 T15089 amod nuclear,translocation
R13101 T15089 T15086 pobj translocation,on
R13102 T15090 T15085 prep by,effect
R13103 T15091 T15092 amod preferential,binding
R13104 T15092 T15085 amod binding,effect
R13105 T15093 T15092 prep to,binding
R13106 T15094 T15098 det the,protein
R13107 T15095 T15098 amod shared,protein
R13108 T15096 T15097 amod nuclear,import
R13109 T15097 T15098 compound import,protein
R13110 T15098 T15099 compound protein,importin-α
R13111 T15099 T15093 pobj importin-α,to
R13112 T15100 T15081 cc and,through
R13113 T15101 T15081 conj by,through
R13114 T15102 T15104 det a,mechanism
R13115 T15103 T15104 amod second,mechanism
R13116 T15104 T15101 pobj mechanism,by
R13117 T15105 T15104 acl involving,mechanism
R13118 T15106 T15107 amod increased,synthesis
R13119 T15107 T15068 dobj synthesis,provide
R13120 T15108 T15107 prep of,synthesis
R13121 T15109 T15108 pobj MKP-1,of
R13122 T15110 T15109 punct ",",MKP-1
R13123 T15111 T15112 nsubj which,inhibits
R13124 T15112 T15109 relcl inhibits,MKP-1
R13125 T15113 T15114 nummod p38,MAPK
R13126 T15114 T15112 dobj MAPK,inhibits
R13127 T15115 T15068 punct ",",provide
R13128 T15116 T15117 advmod thus,preventing
R13129 T15117 T15068 advcl preventing,provide
R13130 T15118 T15119 det the,phosphorylation
R13131 T15119 T15117 dobj phosphorylation,preventing
R13132 T15120 T15119 prep of,phosphorylation
R13133 T15121 T15120 pobj GATA-3,of
R13134 T15122 T15123 nsubj that,is
R13135 T15123 T15121 relcl is,GATA-3
R13136 T15124 T15123 acomp necessary,is
R13137 T15125 T15124 prep for,necessary
R13138 T15126 T15127 amod nuclear,translocation
R13139 T15127 T15125 pobj translocation,for
R13140 T15128 T15127 prep of,translocation
R13141 T15129 T15128 pobj GATA-3,of
R13142 T15130 T15068 punct .,provide
R13143 T15131 T15133 det These,mechanisms
R13144 T15132 T15133 nummod two,mechanisms
R13145 T15133 T15134 nsubj mechanisms,are
R13146 T15134 T15134 ROOT are,are
R13147 T15135 T15134 acomp likely,are
R13148 T15136 T15137 aux to,be
R13149 T15137 T15135 xcomp be,likely
R13150 T15138 T15137 acomp synergistic,be
R13151 T15139 T15137 punct ",",be
R13152 T15140 T15137 advcl accounting,be
R13153 T15141 T15140 prep for,accounting
R13154 T15142 T15146 det the,effect
R13155 T15143 T15146 amod rapid,effect
R13156 T15144 T15143 cc and,rapid
R13157 T15145 T15143 conj potent,rapid
R13158 T15146 T15141 pobj effect,for
R13159 T15147 T15146 prep of,effect
R13160 T15148 T15147 pobj corticosteroids,of
R13161 T15149 T15148 prep on,corticosteroids
R13162 T15150 T15151 amod allergic,inflammation
R13163 T15151 T15149 pobj inflammation,on
R13164 T15152 T15134 punct .,are
R13165 T15153 T15155 nsubjpass This,exemplified
R13166 T15154 T15155 auxpass is,exemplified
R13167 T15155 T15155 ROOT exemplified,exemplified
R13168 T15156 T15155 agent by,exemplified
R13169 T15157 T15160 det the,effect
R13170 T15158 T15160 amod rapid,effect
R13171 T15159 T15160 amod inhibitory,effect
R13172 T15160 T15156 pobj effect,by
R13173 T15161 T15160 prep of,effect
R13174 T15162 T15163 amod topical,corticosteroids
R13175 T15163 T15161 pobj corticosteroids,of
R13176 T15164 T15163 prep on,corticosteroids
R13177 T15165 T15168 amod nasal,release
R13178 T15166 T15168 amod Th2,release
R13179 T15167 T15168 compound cytokine,release
R13180 T15168 T15164 pobj release,on
R13181 T15169 T15155 prep after,exemplified
R13182 T15170 T15171 compound allergen,provocation
R13183 T15171 T15169 pobj provocation,after
R13184 T15172 T15171 prep in,provocation
R13185 T15173 T15172 pobj individuals,in
R13186 T15174 T15173 prep with,individuals
R13187 T15175 T15177 amod seasonal,rhinitis
R13188 T15176 T15177 amod allergic,rhinitis
R13189 T15177 T15174 pobj rhinitis,with
R13190 T15178 T15177 punct (,rhinitis
R13191 T15179 T15180 compound hay,fever
R13192 T15180 T15177 appos fever,rhinitis
R13193 T15181 T15177 punct ),rhinitis
R13194 T15182 T15184 quantmod [,]
R13195 T15183 T15184 nummod 43,]
R13196 T15184 T15173 appos ],individuals
R13197 T15185 T15155 punct .,exemplified
R13198 T15186 T15193 nsubj Prevention,provide
R13199 T15187 T15186 prep of,Prevention
R13200 T15188 T15189 amod phospho-GATA-3,interaction
R13201 T15189 T15187 pobj interaction,of
R13202 T15190 T15189 prep with,interaction
R13203 T15191 T15190 pobj importin-α,with
R13204 T15192 T15193 aux may,provide
R13205 T15193 T15193 ROOT provide,provide
R13206 T15194 T15196 det a,approach
R13207 T15195 T15196 amod new,approach
R13208 T15196 T15193 dobj approach,provide
R13209 T15197 T15196 prep for,approach
R13210 T15198 T15199 det the,development
R13211 T15199 T15197 pobj development,for
R13212 T15200 T15199 prep of,development
R13213 T15201 T15202 compound novel,therapies
R13214 T15202 T15200 pobj therapies,of
R13215 T15203 T15202 prep for,therapies
R13216 T15204 T15205 det the,treatment
R13217 T15205 T15203 pobj treatment,for
R13218 T15206 T15205 prep of,treatment
R13219 T15207 T15208 amod allergic,diseases
R13220 T15208 T15206 pobj diseases,of
R13221 T15209 T15193 punct .,provide
R14001 T16315 T16317 nmod Fluticasone,down-regulates
R14002 T16316 T16317 amod propionate,down-regulates
R14003 T16317 T16317 ROOT down-regulates,down-regulates
R14004 T16318 T16321 nmod Th2,expression
R14005 T16319 T16321 compound cytokine,expression
R14006 T16320 T16321 compound gene,expression
R14007 T16321 T16317 dobj expression,down-regulates
R14008 T16322 T16321 cc and,expression
R14009 T16323 T16317 conj inhibits,down-regulates
R14010 T16324 T16326 nmod GATA-3,import
R14011 T16325 T16326 amod nuclear,import
R14012 T16326 T16323 dobj import,inhibits
R14013 T16327 T16323 punct .,inhibits
R14014 T16328 T16329 punct (,A
R14015 T16329 T16329 ROOT A,A
R14016 T16330 T16329 punct ),A
R14017 T16331 T16334 amod Anti-CD3,treatment
R14018 T16332 T16334 nmod /,treatment
R14019 T16333 T16334 nummod CD28,treatment
R14020 T16334 T16334 ROOT treatment,treatment
R14021 T16335 T16334 prep of,treatment
R14022 T16336 T16337 amod HuT-78,cells
R14023 T16337 T16338 compound cells,results
R14024 T16338 T16335 pobj results,of
R14025 T16339 T16338 prep in,results
R14026 T16340 T16339 pobj translocation,in
R14027 T16341 T16340 prep of,translocation
R14028 T16342 T16341 pobj GATA-3,of
R14029 T16343 T16334 prep from,treatment
R14030 T16344 T16345 det the,cytoplasm
R14031 T16345 T16343 pobj cytoplasm,from
R14032 T16346 T16334 prep to,treatment
R14033 T16347 T16348 det the,nucleus
R14034 T16348 T16346 pobj nucleus,to
R14035 T16349 T16334 prep within,treatment
R14036 T16350 T16351 nummod 30,min
R14037 T16351 T16349 pobj min,within
R14038 T16352 T16334 punct .,treatment
R14039 T16353 T16361 punct (,used
R14040 T16354 T16361 nsubjpass B,used
R14041 T16355 T16354 punct ),B
R14042 T16356 T16357 compound Histone,H1
R14043 T16357 T16354 appos H1,B
R14044 T16358 T16357 cc and,H1
R14045 T16359 T16357 conj MEK-1,H1
R14046 T16360 T16361 auxpass were,used
R14047 T16361 T16361 ROOT used,used
R14048 T16362 T16363 aux to,confirm
R14049 T16363 T16361 xcomp confirm,used
R14050 T16364 T16365 amod distinct,separation
R14051 T16365 T16363 dobj separation,confirm
R14052 T16366 T16365 prep of,separation
R14053 T16367 T16370 amod cytoplasmic,extracts
R14054 T16368 T16367 cc and,cytoplasmic
R14055 T16369 T16367 conj nuclear,cytoplasmic
R14056 T16370 T16366 pobj extracts,of
R14057 T16371 T16363 prep in,confirm
R14058 T16372 T16374 nummod three,experiments
R14059 T16373 T16374 amod separate,experiments
R14060 T16374 T16371 pobj experiments,in
R14061 T16375 T16361 punct .,used
R14062 T16376 T16377 punct (,C
R14063 T16377 T16381 nmod C,analysis
R14064 T16378 T16377 punct ),C
R14065 T16379 T16381 amod Western,analysis
R14066 T16380 T16381 compound blot,analysis
R14067 T16381 T16386 nsubj analysis,demonstrated
R14068 T16382 T16381 prep of,analysis
R14069 T16383 T16385 amod FP-treated,cells
R14070 T16384 T16385 amod HuT-78,cells
R14071 T16385 T16382 pobj cells,of
R14072 T16386 T16386 ROOT demonstrated,demonstrated
R14073 T16387 T16389 amod impaired,localization
R14074 T16388 T16389 amod nuclear,localization
R14075 T16389 T16386 dobj localization,demonstrated
R14076 T16390 T16389 prep of,localization
R14077 T16391 T16390 pobj GATA-3,of
R14078 T16392 T16389 acl induced,localization
R14079 T16393 T16392 agent by,induced
R14080 T16394 T16397 amod anti-CD3,co-stimulation
R14081 T16395 T16397 nmod /,co-stimulation
R14082 T16396 T16397 nummod CD28,co-stimulation
R14083 T16397 T16393 pobj co-stimulation,by
R14084 T16398 T16392 prep in,induced
R14085 T16399 T16400 det a,time
R14086 T16400 T16398 pobj time,in
R14087 T16401 T16389 punct -,localization
R14088 T16402 T16389 punct (,localization
R14089 T16403 T16389 prep at,localization
R14090 T16404 T16405 nummod 10,−
R14091 T16405 T16408 nmod −,FP
R14092 T16406 T16408 nummod 8,FP
R14093 T16407 T16408 compound M,FP
R14094 T16408 T16403 pobj FP,at
R14095 T16409 T16389 punct ),localization
R14096 T16410 T16389 cc and,localization
R14097 T16411 T16389 conj concentration,localization
R14098 T16412 T16389 punct -,localization
R14099 T16413 T16389 punct (,localization
R14100 T16414 T16386 prep at,demonstrated
R14101 T16415 T16416 nummod 60,min
R14102 T16416 T16414 pobj min,at
R14103 T16417 T16416 prep after,min
R14104 T16418 T16417 pobj stimulation,after
R14105 T16419 T16386 punct ),demonstrated
R14106 T16420 T16421 amod dependent,manner
R14107 T16421 T16421 ROOT manner,manner
R14108 T16422 T16421 punct .,manner
R14109 T16423 T16425 nsubjpass Cells,pretreated
R14110 T16424 T16425 auxpass were,pretreated
R14111 T16425 T16425 ROOT pretreated,pretreated
R14112 T16426 T16425 prep with,pretreated
R14113 T16427 T16426 pobj FP,with
R14114 T16428 T16425 prep for,pretreated
R14115 T16429 T16430 nummod 30,min
R14116 T16430 T16428 pobj min,for
R14117 T16431 T16425 advmod prior,pretreated
R14118 T16432 T16431 prep to,prior
R14119 T16433 T16432 pobj stimulation,to
R14120 T16434 T16425 punct .,pretreated
R14121 T16435 T16440 nsubjpass MEK1,used
R14122 T16436 T16435 cc and,MEK1
R14123 T16437 T16438 compound histone,H1
R14124 T16438 T16435 conj H1,MEK1
R14125 T16439 T16440 auxpass were,used
R14126 T16440 T16440 ROOT used,used
R14127 T16441 T16442 aux to,demonstrate
R14128 T16442 T16440 xcomp demonstrate,used
R14129 T16443 T16444 amod equal,cytoplasmic
R14130 T16444 T16442 dobj cytoplasmic,demonstrate
R14131 T16445 T16444 cc and,cytoplasmic
R14132 T16446 T16444 conj nuclear,cytoplasmic
R14133 T16447 T16442 advcl loading,demonstrate
R14134 T16448 T16447 advmod respectively,loading
R14135 T16449 T16440 punct .,used
R14136 T16450 T16452 nsubjpass Results,presented
R14137 T16451 T16452 auxpass are,presented
R14138 T16452 T16452 ROOT presented,presented
R14139 T16453 T16454 advmod graphically,below
R14140 T16454 T16452 prep below,presented
R14141 T16455 T16452 prep as,presented
R14142 T16456 T16458 amod mean,SEM
R14143 T16457 T16458 compound ±,SEM
R14144 T16458 T16455 pobj SEM,as
R14145 T16459 T16458 prep of,SEM
R14146 T16460 T16461 advmod at,least
R14147 T16461 T16462 advmod least,three
R14148 T16462 T16464 nummod three,experiments
R14149 T16463 T16464 amod independent,experiments
R14150 T16464 T16459 pobj experiments,of
R14151 T16465 T16452 punct .,presented
R14152 T16466 T16468 compound ***,<
R14153 T16467 T16468 compound p,<
R14154 T16468 T16470 nsubj <,compared
R14155 T16469 T16468 nummod 0.001,<
R14156 T16470 T16470 ROOT compared,compared
R14157 T16471 T16470 prep to,compared
R14158 T16472 T16471 pobj t,to
R14159 T16473 T16474 punct =,0
R14160 T16474 T16472 prep 0,t
R14161 T16475 T16470 punct .,compared
R14162 T16476 T16479 punct (,RT-PCR
R14163 T16477 T16479 nmod D,RT-PCR
R14164 T16478 T16479 punct ),RT-PCR
R14165 T16479 T16479 ROOT RT-PCR,RT-PCR
R14166 T16480 T16479 acl showing,RT-PCR
R14167 T16481 T16483 mark that,inhibits
R14168 T16482 T16483 nsubj FP,inhibits
R14169 T16483 T16480 ccomp inhibits,showing
R14170 T16484 T16488 nmod IL-4,expression
R14171 T16485 T16484 cc and,IL-4
R14172 T16486 T16484 conj IL-5,IL-4
R14173 T16487 T16488 compound mRNA,expression
R14174 T16488 T16483 dobj expression,inhibits
R14175 T16489 T16488 prep in,expression
R14176 T16490 T16491 amod CD3/CD28-costimulated,cells
R14177 T16491 T16489 pobj cells,in
R14178 T16492 T16479 punct .,RT-PCR
R14179 T16493 T16495 nsubjpass GAPDH,used
R14180 T16494 T16495 auxpass was,used
R14181 T16495 T16495 ROOT used,used
R14182 T16496 T16495 prep as,used
R14183 T16497 T16499 det a,control
R14184 T16498 T16499 compound loading,control
R14185 T16499 T16496 pobj control,as
R14186 T16500 T16495 punct .,used
R14187 T16501 T16502 amod Lower,panels
R14188 T16502 T16503 nsubj panels,show
R14189 T16503 T16503 ROOT show,show
R14190 T16504 T16505 amod graphical,analysis
R14191 T16505 T16503 dobj analysis,show
R14192 T16506 T16505 prep of,analysis
R14193 T16507 T16506 pobj results,of
R14194 T16508 T16507 acl presented,results
R14196 T16510 T16512 amod mean,SEM
R14197 T16511 T16512 compound ±,SEM
R14198 T16512 T16509 pobj SEM,as
R14199 T16513 T16512 prep of,SEM
R14200 T16514 T16515 advmod at,least
R14201 T16515 T16516 advmod least,three
R14202 T16516 T16518 nummod three,experiments
R14203 T16517 T16518 amod independent,experiments
R14204 T16518 T16513 pobj experiments,of
R14205 T16519 T16503 punct .,show
R14206 T16520 T16522 dep ###,<
R14207 T16521 T16522 nmod p,<
R14208 T16522 T16522 ROOT <,<
R14209 T16523 T16532 nsubj 0.001,compared
R14210 T16524 T16532 prep compared,compared
R14211 T16525 T16526 aux to,control
R14212 T16526 T16524 xcomp control,compared
R14213 T16527 T16532 punct ",",compared
R14214 T16528 T16531 nmod ***,0.001
R14215 T16529 T16531 nmod p,0.001
R14216 T16530 T16531 nmod <,0.001
R14217 T16531 T16532 nsubj 0.001,compared
R14218 T16532 T16532 ROOT compared,compared
R14219 T16533 T16532 prep to,compared
R14220 T16534 T16535 compound anti-CD3,/
R14221 T16535 T16536 compound /,CD28
R14222 T16536 T16533 pobj CD28,to
R14223 T16537 T16536 acl stimulated,CD28
R14224 T16538 T16532 punct .,compared
R14225 T16539 T16542 punct (,FP
R14226 T16540 T16542 nmod E,FP
R14227 T16541 T16542 punct ),FP
R14228 T16542 T16547 nsubj FP,reduces
R14229 T16543 T16545 punct (,nM
R14230 T16544 T16545 nummod 10,nM
R14231 T16545 T16542 appos nM,FP
R14232 T16546 T16542 punct ),FP
R14233 T16547 T16547 ROOT reduces,reduces
R14234 T16548 T16549 det the,ability
R14235 T16549 T16547 dobj ability,reduces
R14236 T16550 T16549 prep of,ability
R14237 T16551 T16554 amod anti-CD3,GATA-3
R14238 T16552 T16554 nmod /,GATA-3
R14239 T16553 T16554 amod CD28-stimulated,GATA-3
R14240 T16554 T16550 pobj GATA-3,of
R14241 T16555 T16556 aux to,associate
R14242 T16556 T16549 acl associate,ability
R14243 T16557 T16556 prep with,associate
R14244 T16558 T16561 det the,promoter
R14245 T16559 T16561 amod native,promoter
R14246 T16560 T16561 compound IL-5,promoter
R14247 T16561 T16557 pobj promoter,with
R14248 T16562 T16563 nummod 60,min
R14249 T16563 T16561 appos min,promoter
R14250 T16564 T16563 prep after,min
R14251 T16565 T16564 pobj stimulation,after
R14252 T16566 T16547 punct .,reduces
R14253 T16567 T16570 nsubjpass Data,shown
R14254 T16568 T16570 auxpass are,shown
R14255 T16569 T16570 advmod also,shown
R14256 T16570 T16570 ROOT shown,shown
R14257 T16571 T16570 advmod graphically,shown
R14258 T16572 T16570 prep as,shown
R14259 T16573 T16575 amod mean,SEM
R14260 T16574 T16575 compound ±,SEM
R14261 T16575 T16572 pobj SEM,as
R14262 T16576 T16575 prep of,SEM
R14263 T16577 T16579 nummod three,experiments
R14264 T16578 T16579 amod independent,experiments
R14265 T16579 T16576 pobj experiments,of
R14266 T16580 T16570 punct .,shown
R14267 T16581 T16582 det All,data
R14268 T16582 T16584 nsubjpass data,analysed
R14269 T16583 T16584 auxpass were,analysed
R14270 T16584 T16584 ROOT analysed,analysed
R14271 T16585 T16584 agent by,analysed
R14272 T16586 T16585 pobj ANOVA,by
R14273 T16587 T16584 acl followed,analysed
R14274 T16588 T16587 agent by,followed
R14275 T16589 T16588 pobj Newman-Keuls,by
R14276 T16590 T16590 ROOT post-test,post-test
R14277 T16591 T16584 punct .,analysed
R14667 T17105 T17106 compound Fluticasone,propionate
R14668 T17106 T17107 nsubj propionate,reduces
R14669 T17107 T17107 ROOT reduces,reduces
R14670 T17108 T17109 amod GATA-3,association
R14671 T17109 T17107 dobj association,reduces
R14672 T17110 T17109 prep with,association
R14673 T17111 T17115 amod importin-α,import
R14674 T17112 T17111 cc and,importin-α
R14675 T17113 T17111 conj GATA-3,importin-α
R14676 T17114 T17115 amod nuclear,import
R14677 T17115 T17110 pobj import,with
R14678 T17116 T17107 punct .,reduces
R14679 T17117 T17118 punct (,A
R14680 T17118 T17122 nmod A,analysis
R14681 T17119 T17118 punct ),A
R14682 T17120 T17122 amod Western,analysis
R14683 T17121 T17122 compound blot,analysis
R14684 T17122 T17123 nsubj analysis,demonstrates
R14685 T17123 T17123 ROOT demonstrates,demonstrates
R14686 T17124 T17133 det a,FP
R14687 T17125 T17133 nmod time,FP
R14688 T17126 T17133 punct -,FP
R14689 T17127 T17133 punct (,FP
R14690 T17128 T17133 prep at,FP
R14691 T17129 T17131 quantmod 10,8
R14692 T17130 T17131 quantmod −,8
R14718 T17156 T17123 punct .,demonstrates
R14719 T17157 T17159 det A,control
R14720 T17158 T17159 amod positive,control
R14721 T17159 T17166 nsubjpass control,shown
R14722 T17160 T17159 prep for,control
R14723 T17161 T17162 compound GR,association
R14724 T17162 T17160 pobj association,for
R14725 T17163 T17162 prep with,association
R14726 T17164 T17163 pobj importin,with
R14727 T17165 T17166 auxpass is,shown
R14728 T17166 T17166 ROOT shown,shown
R14729 T17167 T17166 punct .,shown
R14730 T17168 T17174 nsubjpass Quantification,shown
R14731 T17169 T17168 prep of,Quantification
R14732 T17170 T17172 det the,data
R14733 T17171 T17172 compound densitometry,data
R14734 T17172 T17169 pobj data,of
R14735 T17173 T17174 auxpass is,shown
R14736 T17174 T17174 ROOT shown,shown
R14737 T17175 T17174 prep below,shown
R14738 T17176 T17174 punct .,shown
R14739 T17177 T17178 det Each,bar
R14740 T17178 T17179 nsubj bar,represents
R14741 T17179 T17179 ROOT represents,represents
R14742 T17180 T17182 amod mean,SEM
R14743 T17181 T17182 compound ±,SEM
R14744 T17182 T17179 dobj SEM,represents
R14745 T17183 T17182 prep of,SEM
R14796 T17234 T17237 amod FP-activated,translocation
R14797 T17235 T17237 nmod GR,translocation
R14798 T17236 T17237 amod nuclear,translocation
R14799 T17237 T17238 npadvmod translocation,measured
R14800 T17238 T17232 acl measured,induction
R14801 T17239 T17238 agent by,measured
R14802 T17240 T17239 pobj IP,by
R14803 T17241 T17209 punct .,demonstrated
R14804 T17242 T17248 nsubjpass Quantification,shown
R14805 T17243 T17242 prep of,Quantification
R14806 T17244 T17246 det the,data
R14807 T17245 T17246 compound densitometry,data
R14808 T17246 T17243 pobj data,of
R14809 T17247 T17248 auxpass is,shown
R14810 T17248 T17248 ROOT shown,shown
R14811 T17249 T17248 prep below,shown
R14812 T17250 T17248 punct .,shown
R14813 T17251 T17252 det Each,bar
R14814 T17252 T17253 nsubj bar,represents
R14815 T17253 T17253 ROOT represents,represents
R14816 T17254 T17256 amod mean,SEM
R14817 T17255 T17256 compound ±,SEM
R14818 T17256 T17253 dobj SEM,represents
R14819 T17257 T17256 prep of,SEM
R14820 T17258 T17259 advmod at,least
R14821 T17259 T17260 advmod least,three
R14822 T17260 T17262 nummod three,experiments
R14823 T17261 T17262 amod independent,experiments
R14849 T17287 T17288 nummod CD28,co-stimulation
R14850 T17288 T17289 nsubj co-stimulation,demonstrated
R14851 T17289 T17289 ROOT demonstrated,demonstrated
R14852 T17290 T17292 det a,decrease
R14853 T17291 T17292 amod concentration-dependent,decrease
R14854 T17292 T17289 dobj decrease,demonstrated
R14855 T17293 T17292 prep in,decrease
R14856 T17294 T17293 pobj GATA-3,in
R14857 T17295 T17296 compound importin-α,association
R14858 T17296 T17292 appos association,decrease
R14859 T17297 T17292 prep at,decrease
R14860 T17298 T17299 nummod 20,min
R14861 T17299 T17297 pobj min,at
R14862 T17300 T17289 punct .,demonstrated
R14863 T17301 T17307 nsubjpass Quantification,shown
R14864 T17302 T17301 prep of,Quantification
R14865 T17303 T17305 det the,data
R14866 T17304 T17305 compound densitometry,data
R14867 T17305 T17302 pobj data,of
R14868 T17306 T17307 auxpass is,shown
R14869 T17307 T17307 ROOT shown,shown
R14870 T17308 T17307 prep below,shown
R14871 T17309 T17307 punct .,shown
R14872 T17310 T17311 det Each,bar
R14873 T17311 T17312 nsubj bar,represents
R14874 T17312 T17312 ROOT represents,represents
R14875 T17313 T17315 amod mean,SEM
R14876 T17314 T17315 compound ±,SEM
R14877 T17315 T17312 dobj SEM,represents
R14878 T17316 T17315 prep of,SEM
R14879 T17317 T17318 advmod at,least
R14880 T17318 T17319 advmod least,three
R14881 T17319 T17321 nummod three,experiments
R14882 T17320 T17321 amod independent,experiments
R14883 T17321 T17316 pobj experiments,of
R14884 T17322 T17312 punct .,represents
R14885 T17323 T17325 dep ###,<
R14886 T17324 T17325 compound p,<
R14887 T17325 T17325 ROOT <,<
R14888 T17326 T17326 ROOT 0.001,0.001
R14889 T17327 T17335 prep compared,compared
R14890 T17328 T17329 aux to,control
R14891 T17329 T17327 xcomp control,compared
R14892 T17330 T17333 punct ",",<
R14893 T17331 T17333 nmod ***,<
R14894 T17332 T17333 nmod p,<
R14895 T17333 T17334 nmod <,0.001
R14896 T17334 T17335 npadvmod 0.001,compared
R14897 T17335 T17326 prep compared,0.001
R14898 T17336 T17335 prep to,compared
R14899 T17337 T17336 pobj αCD3,to
R14900 T17338 T17340 amod /,cells
R14901 T17339 T17340 amod CD28-stimulated,cells
R14902 T17340 T17337 dobj cells,αCD3
R14903 T17341 T17326 punct .,0.001
R14904 T17342 T17343 punct (,D
R14905 T17343 T17343 ROOT D,D
R14906 T17344 T17343 punct ),D
R14907 T17345 T17346 amod GFP-tagged,GATA-3
R14908 T17346 T17348 nsubjpass GATA-3,overexpressed
R14909 T17347 T17348 auxpass was,overexpressed
R14910 T17348 T17348 ROOT overexpressed,overexpressed
R14911 T17349 T17348 cc and,overexpressed
R14912 T17350 T17348 conj cells,overexpressed
R14913 T17351 T17350 acl stimulated,cells
R14914 T17352 T17355 punct (,c
R14915 T17353 T17355 nmod b,c
R14916 T17354 T17355 punct ",",c
R14917 T17355 T17351 appos c,stimulated
R14918 T17356 T17355 punct ),c
R14919 T17357 T17355 cc or,c
R14920 T17358 T17359 neg not,(
R14921 T17359 T17360 punct (,a
R14922 T17360 T17362 meta a,for
R14923 T17361 T17360 punct ),a
R14924 T17362 T17355 conj for,c
R14925 T17363 T17364 nummod 30,min
R14926 T17364 T17362 pobj min,for
R14927 T17365 T17364 prep with,min
R14928 T17366 T17367 compound anti-CD3,/
R14929 T17367 T17368 compound /,CD28
R14930 T17368 T17365 pobj CD28,with
R14931 T17369 T17348 punct .,overexpressed
R14932 T17370 T17371 det The,effect
R14933 T17371 T17390 nsubjpass effect,shown
R14934 T17372 T17371 prep of,effect
R14935 T17373 T17375 nummod 30,pretreatment
R14936 T17374 T17375 compound min,pretreatment
R14937 T17375 T17372 pobj pretreatment,of
R14938 T17376 T17375 prep of,pretreatment
R14939 T17377 T17376 pobj cells,of
R14940 T17378 T17371 prep with,effect
R14941 T17379 T17378 pobj FP,with
R14942 T17380 T17379 punct (,FP
R14943 T17381 T17382 nummod 10,−
R14944 T17382 T17379 appos −,FP
R14945 T17383 T17384 nummod 8,M
R14946 T17384 T17390 nsubjpass M,shown
R14947 T17385 T17384 punct ",",M
R14948 T17386 T17384 appos c,M
R14949 T17387 T17384 punct ),M
R14950 T17388 T17390 auxpass is,shown
R14951 T17389 T17390 advmod also,shown
R14952 T17390 T17390 ROOT shown,shown
R14953 T17391 T17390 punct .,shown
R14954 T17392 T17393 det All,data
R14955 T17393 T17395 nsubjpass data,analysed
R14956 T17394 T17395 auxpass were,analysed
R14957 T17395 T17395 ROOT analysed,analysed
R14958 T17396 T17395 agent by,analysed
R14959 T17397 T17396 pobj ANOVA,by
R14960 T17398 T17395 prep followed,analysed
R14961 T17399 T17398 agent by,followed
R14962 T17400 T17399 pobj Newman-Keuls,by
R14963 T17401 T17395 conj post-test,analysed
R14964 T17402 T17395 punct .,analysed
R15301 T17853 T17854 compound Fluticasone,propionate
R15302 T17854 T17854 ROOT propionate,propionate
R15303 T17855 T17865 nsubjpass mediated,associated
R15304 T17856 T17855 dobj inhibition,mediated
R15305 T17857 T17856 prep of,inhibition
R15306 T17858 T17861 nummod p38,phosphorylation
R15307 T17859 T17861 nmod MAP,phosphorylation
R15308 T17860 T17861 compound kinase,phosphorylation
R15309 T17861 T17857 pobj phosphorylation,of
R15310 T17862 T17861 cc and,phosphorylation
R15311 T17863 T17861 conj activation,phosphorylation
R15312 T17864 T17865 auxpass is,associated
R15313 T17865 T17865 ROOT associated,associated
R15314 T17866 T17865 prep with,associated
R15315 T17867 T17869 det a,down-regulation
R15316 T17868 T17869 amod marked,down-regulation
R15317 T17869 T17866 pobj down-regulation,with
R15318 T17870 T17869 prep of,down-regulation
R15319 T17871 T17873 amod GATA-3,phosphorylation
R15320 T17872 T17873 compound serine,phosphorylation
R15321 T17873 T17870 pobj phosphorylation,of
R15322 T17874 T17865 punct .,associated
R15323 T17875 T17876 punct (,A
R15324 T17876 T17880 nmod A,analysis
R15325 T17877 T17876 punct ),A
R15326 T17878 T17880 amod Western,analysis
R15327 T17879 T17880 compound blot,analysis
R15328 T17880 T17881 nsubj analysis,shows
R15329 T17881 T17881 ROOT shows,shows
R15330 T17882 T17894 mark that,reduced
R15331 T17883 T17888 nmod FP,M
R15332 T17884 T17886 punct (,−
R15333 T17885 T17886 nummod 10,−
R15334 T17886 T17883 appos −,FP
R15335 T17887 T17888 nummod 8,M
R15336 T17888 T17894 nsubj M,reduced
R15337 T17889 T17888 punct ",",M
R15338 T17890 T17891 nummod 30,min
R15339 T17891 T17888 appos min,M
R15340 T17892 T17891 punct ),min
R15341 T17893 T17894 nsubj treatment,reduced
R15342 T17894 T17881 ccomp reduced,shows
R15343 T17895 T17896 amod dual,phosphorylation
R15344 T17896 T17894 dobj phosphorylation,reduced
R15345 T17897 T17898 punct (,threonine-180
R15346 T17898 T17896 appos threonine-180,phosphorylation
R15347 T17899 T17898 cc and,threonine-180
R15348 T17900 T17898 conj tyrosine-182,threonine-180
R15349 T17901 T17898 punct ),threonine-180
R15350 T17902 T17896 prep of,phosphorylation
R15351 T17903 T17904 nummod p38,MAPK
R15352 T17904 T17902 pobj MAPK,of
R15353 T17905 T17904 prep in,MAPK
R15354 T17906 T17907 compound anti-CD3,/
R15355 T17907 T17905 pobj /,in
R15356 T17908 T17907 nummod CD28,/
R15357 T17909 T17911 amod co-stimulated,cells
R15358 T17910 T17911 amod HuT-78,cells
R15359 T17911 T17896 appos cells,phosphorylation
R15360 T17912 T17881 punct .,shows
R15361 T17913 T17917 punct (,course
R15362 T17914 T17917 compound B,course
R15363 T17915 T17916 punct ),Time
R15364 T17916 T17917 compound Time,course
R15365 T17917 T17917 ROOT course,course
R15366 T17918 T17917 prep of,course
R15367 T17919 T17920 det the,effect
R15368 T17920 T17918 pobj effect,of
R15369 T17921 T17920 prep of,effect
R15370 T17922 T17921 pobj FP,of
R15371 T17923 T17922 punct (,FP
R15372 T17924 T17926 quantmod 10,8
R15373 T17925 T17926 quantmod −,8
R15374 T17926 T17927 npadvmod 8,M
R15375 T17927 T17922 appos M,FP
R15376 T17928 T17922 punct ),FP
R15377 T17929 T17920 prep on,effect
R15378 T17930 T17929 pobj phosphorylation,on
R15379 T17931 T17930 prep of,phosphorylation
R15380 T17932 T17934 amod activated,factor
R15381 T17933 T17934 compound transcription,factor
R15382 T17934 T17931 pobj factor,of
R15383 T17935 T17934 nummod 2,factor
R15384 T17936 T17937 punct (,ATF-2
R15385 T17937 T17934 appos ATF-2,factor
R15386 T17938 T17937 punct ),ATF-2
R15387 T17939 T17937 punct ",",ATF-2
R15388 T17940 T17941 det a,measure
R15389 T17941 T17937 appos measure,ATF-2
R15390 T17942 T17941 prep of,measure
R15391 T17943 T17945 nummod p38,activity
R15392 T17944 T17945 compound MAPK,activity
R15393 T17945 T17942 pobj activity,of
R15394 T17946 T17917 punct .,course
R15395 T17947 T17948 punct (,C
R15396 T17948 T17951 nmod C,inhibition
R15397 T17949 T17948 punct ),C
R15398 T17950 T17951 amod FP-induced,inhibition
R15399 T17951 T17957 nsubjpass inhibition,associated
R15400 T17952 T17951 prep of,inhibition
R15401 T17953 T17955 nummod p38,activity
R15402 T17954 T17955 compound MAPK,activity
R15403 T17955 T17952 pobj activity,of
R15404 T17956 T17957 auxpass is,associated
R15405 T17957 T17957 ROOT associated,associated
R15406 T17958 T17957 prep with,associated
R15407 T17959 T17960 det the,decrease
R15408 T17960 T17958 pobj decrease,with
R15409 T17961 T17960 prep of,decrease
R15410 T17962 T17966 dep anti-CD3,induced
R15411 T17963 T17966 dep /,induced
R15412 T17964 T17965 nummod CD28,co-stimulation
R15413 T17965 T17963 appos co-stimulation,/
R15414 T17966 T17957 advcl induced,associated
R15415 T17967 T17968 amod serine,phosphorylation
R15416 T17968 T17966 dobj phosphorylation,induced
R15417 T17969 T17970 punct (,P-Ser
R15418 T17970 T17968 appos P-Ser,phosphorylation
R15419 T17971 T17970 punct ),P-Ser
R15420 T17972 T17968 prep of,phosphorylation
R15421 T17973 T17972 pobj GATA-3,of
R15422 T17974 T17966 punct .,induced
R15423 T17975 T17988 prep For,shown
R15424 T17976 T17977 punct (,A
R15425 T17977 T17978 det A,C
R15426 T17978 T17975 pobj C,For
R15427 T17979 T17978 punct ),C
R15428 T17980 T17988 punct ",",shown
R15429 T17981 T17988 nsubjpass quantification,shown
R15430 T17982 T17981 prep of,quantification
R15431 T17983 T17985 det the,data
R15432 T17984 T17985 compound densitometry,data
R15433 T17985 T17982 pobj data,of
R15434 T17986 T17988 auxpass is,shown
R15435 T17987 T17988 advmod also,shown
R15436 T17988 T17988 ROOT shown,shown
R15437 T17989 T17988 punct .,shown
R15438 T17990 T17991 det Each,bar
R15439 T17991 T17992 nsubj bar,represents
R15440 T17992 T17992 ROOT represents,represents
R15441 T17993 T17995 amod mean,SEM
R15442 T17994 T17995 compound ±,SEM
R15443 T17995 T17992 dobj SEM,represents
R15444 T17996 T17995 prep of,SEM
R15445 T17997 T17998 advmod at,least
R15446 T17998 T17999 advmod least,three
R15447 T17999 T18001 nummod three,experiments
R15448 T18000 T18001 amod independent,experiments
R15449 T18001 T17996 pobj experiments,of
R15450 T18002 T17992 punct .,represents
R15451 T18003 T18005 dep ###,<
R15452 T18004 T18005 compound p,<
R15453 T18005 T18005 ROOT <,<
R15454 T18006 T18015 nsubj 0.001,compared
R15455 T18007 T18015 prep compared,compared
R15456 T18008 T18009 aux to,control
R15457 T18009 T18007 xcomp control,compared
R15458 T18010 T18015 punct ",",compared
R15459 T18011 T18013 nmod ***,<
R15460 T18012 T18013 nmod p,<
R15461 T18013 T18014 nmod <,0.001
R15462 T18014 T18015 nsubj 0.001,compared
R15463 T18015 T18015 ROOT compared,compared
R15464 T18016 T18015 prep to,compared
R15465 T18017 T18016 pobj αCD3,to
R15466 T18018 T18020 amod /,cells
R15467 T18019 T18020 amod CD28-stimulated,cells
R15468 T18020 T18017 dobj cells,αCD3
R15469 T18021 T18015 punct .,compared
R15470 T18022 T18026 punct (,induced
R15471 T18023 T18025 nmod D,FP
R15472 T18024 T18025 punct ),FP
R15473 T18025 T18026 nsubj FP,induced
R15474 T18026 T18026 ROOT induced,induced
R15475 T18027 T18028 compound MKP-1,mRNA
R15476 T18028 T18026 dobj mRNA,induced
R15477 T18029 T18026 prep in,induced
R15478 T18030 T18032 det a,manner
R15479 T18031 T18032 amod concentration-dependent,manner
R15480 T18032 T18029 pobj manner,in
R15481 T18033 T18026 punct .,induced
R15482 T18034 T18035 det All,results
R15483 T18035 T18036 nsubj results,are
R15484 T18036 T18036 ROOT are,are
R15485 T18037 T18036 attr representative,are
R15486 T18038 T18037 prep of,representative
R15487 T18039 T18040 advmod at,least
R15488 T18040 T18041 advmod least,three
R15489 T18041 T18043 nummod three,experiments
R15490 T18042 T18043 amod independent,experiments
R15491 T18043 T18038 pobj experiments,of
R15492 T18044 T18043 cc and,experiments
R15493 T18045 T18047 advmod where,expressed
R15494 T18046 T18047 amod appropriate,expressed
R15495 T18047 T18037 relcl expressed,representative
R15496 T18048 T18047 prep as,expressed
R15521 T18073 T18072 prep of,representative
R15522 T18074 T18076 nummod two,experiments
R15523 T18075 T18076 amod independent,experiments
R15524 T18076 T18073 pobj experiments,of
R15525 T18077 T18071 punct .,are
R15526 T18078 T18079 det All,data
R15527 T18079 T18085 nsubjpass data,analysed
R15528 T18080 T18079 prep except,data
R15529 T18081 T18082 punct (,E
R15530 T18082 T18080 pobj E,except
R15531 T18083 T18079 punct ),data
R15532 T18084 T18085 auxpass were,analysed
R15533 T18085 T18085 ROOT analysed,analysed
R15534 T18086 T18085 agent by,analysed
R15535 T18087 T18086 pobj ANOVA,by
R15536 T18088 T18085 prep followed,analysed
R15537 T18089 T18088 agent by,followed
R15538 T18090 T18089 pobj Newman-Keuls,by
R15539 T18091 T18088 advmod post-test,followed
R15540 T18092 T18085 punct .,analysed
R15666 T18334 T18335 compound Fluticasone,propionate
R15667 T18335 T18336 nsubj propionate,competes
R15668 T18336 T18336 ROOT competes,competes
R15669 T18337 T18336 prep with,competes
R15670 T18338 T18337 pobj phospho-GATA-3,with
R15671 T18339 T18338 prep for,phospho-GATA-3
R15672 T18340 T18339 pobj importin-α,for
R15673 T18341 T18336 punct .,competes
R15674 T18342 T18346 punct (,representation
R15675 T18343 T18346 det A,representation
R15676 T18344 T18346 punct ),representation
R15677 T18345 T18346 amod schematic,representation
R15678 T18346 T18346 ROOT representation,representation
R15679 T18347 T18346 prep of,representation
R15680 T18348 T18353 det the,assay
R15681 T18349 T18353 nmod in,assay
R15682 T18350 T18353 amod vitro,assay
R15683 T18351 T18352 amod binding,competition
R15684 T18352 T18353 compound competition,assay
R15685 T18353 T18347 pobj assay,of
R15686 T18354 T18346 punct .,representation
R15687 T18355 T18358 punct (,GR
R15688 T18356 T18358 nmod B,GR
R15689 T18357 T18358 punct ),GR
R15690 T18358 T18359 nsubj GR,isolated
R15691 T18359 T18359 ROOT isolated,isolated
R15692 T18360 T18359 prep from,isolated
R15693 T18361 T18360 pobj FP,from
R15694 T18362 T18361 punct (,FP
R15695 T18363 T18364 nummod 10,−
R15696 T18364 T18361 appos −,FP
R15697 T18365 T18366 nummod 8,M
R15698 T18366 T18364 appos M,−
R15699 T18367 T18364 punct ),−
R15700 T18368 T18369 amod stimulated,cells
R15701 T18369 T18370 nsubj cells,enhances
R15702 T18370 T18370 ROOT enhances,enhances
R15703 T18371 T18370 dobj GR,enhances
R15704 T18372 T18373 nsubj importin-α,binding
R15705 T18373 T18370 oprd binding,enhances
R15706 T18374 T18373 prep in,binding
R15707 T18375 T18376 det the,presence
R15708 T18376 T18374 pobj presence,in
R15709 T18377 T18378 punct (,•
R15710 T18378 T18376 appos •,presence
R15711 T18379 T18378 punct ),•
R15712 T18380 T18378 cc and,•
R15713 T18381 T18378 conj absence,•
R15714 T18382 T18383 punct (,▪
R15715 T18383 T18381 appos ▪,absence
R15716 T18384 T18376 punct ),presence
R15717 T18385 T18376 prep of,presence
R15718 T18386 T18387 amod activated,GATA-3
R15719 T18387 T18385 pobj GATA-3,of
R15720 T18388 T18370 punct .,enhances
R15721 T18389 T18393 punct *,compared
R15722 T18390 T18391 compound p,<
R15723 T18391 T18392 compound <,0.05
R15724 T18392 T18393 nsubj 0.05,compared
R15725 T18393 T18393 ROOT compared,compared
R15726 T18394 T18393 prep to,compared
R15727 T18395 T18397 det no,GR
R15728 T18396 T18397 amod activated,GR
R15729 T18397 T18394 pobj GR,to
R15730 T18398 T18393 punct .,compared
R15731 T18399 T18400 punct (,C
R15732 T18400 T18400 ROOT C,C
R15733 T18401 T18400 punct ),C
R15734 T18402 T18403 nsubj GATA-3,isolated
R15735 T18403 T18412 csubj isolated,attenuate
R15736 T18404 T18403 prep from,isolated
R15737 T18405 T18406 compound anti-CD3,/
R15738 T18406 T18408 npadvmod /,stimulated
R15739 T18407 T18406 nummod CD28,/
R15740 T18408 T18409 amod stimulated,cells
R15741 T18409 T18404 pobj cells,from
R15742 T18410 T18412 aux does,attenuate
R15743 T18411 T18412 neg not,attenuate
R15744 T18412 T18412 ROOT attenuate,attenuate
R15745 T18413 T18412 dobj GR,attenuate
R15746 T18414 T18415 amod importin-α,association
R15747 T18415 T18413 appos association,GR
R15748 T18416 T18412 punct .,attenuate
R15749 T18417 T18417 ROOT *,*
R15750 T18418 T18419 compound p,<
R15751 T18419 T18420 compound <,0.05
R15752 T18420 T18421 nsubj 0.05,compared
R15753 T18421 T18421 ROOT compared,compared
R15754 T18422 T18423 aux to,control
R15755 T18423 T18421 xcomp control,compared
R15756 T18424 T18421 punct .,compared
R15757 T18425 T18430 punct (,blocks
R15758 T18426 T18429 compound D,GR
R15759 T18427 T18428 punct ),Activated
R15760 T18428 T18429 compound Activated,GR
R15761 T18429 T18430 nsubj GR,blocks
R15762 T18430 T18430 ROOT blocks,blocks
R15763 T18431 T18432 det the,ability
R15764 T18432 T18430 dobj ability,blocks
R15765 T18433 T18432 prep of,ability
R15766 T18434 T18435 amod purified,phospho-GATA-3
R15767 T18435 T18436 amod phospho-GATA-3,isolated
R15768 T18436 T18433 pobj isolated,of
R15769 T18437 T18436 prep from,isolated
R15770 T18438 T18439 compound anti-CD3,/
R15771 T18439 T18440 compound /,CD28
R15772 T18440 T18437 pobj CD28,from
R15773 T18441 T18442 amod stimulated,cells
R15774 T18442 T18430 dobj cells,blocks
R15775 T18443 T18442 acl interacting,cells
R15776 T18444 T18443 prep with,interacting
R15777 T18445 T18446 amod immobilised,importin-α
R15779 T18447 T18443 prep in,interacting
R15780 T18448 T18452 det an,assay
R15781 T18449 T18452 nmod in,assay
R15782 T18450 T18452 amod vitro,assay
R15783 T18451 T18452 amod binding,assay
R15784 T18452 T18447 pobj assay,in
R15785 T18453 T18430 punct .,blocks
R15786 T18454 T18461 punct *,isolated
R15787 T18455 T18456 compound p,<
R15788 T18456 T18457 compound <,0.05
R15789 T18457 T18461 nsubjpass 0.05,isolated
R15790 T18458 T18461 prep compared,isolated
R15791 T18459 T18461 aux to,isolated
R15792 T18460 T18461 nsubj GATA-3,isolated
R15793 T18461 T18461 ROOT isolated,isolated
R15794 T18462 T18461 prep from,isolated
R15795 T18463 T18464 amod unstimulated,cells
R15796 T18464 T18462 pobj cells,from
R15797 T18465 T18461 punct .,isolated
R15798 T18466 T18468 amod # p,0.05
R15799 T18467 T18468 compound <,0.05
R15800 T18468 T18469 nsubj 0.05,compared
R15801 T18469 T18469 ROOT compared,compared
R15802 T18470 T18471 aux to,stimulated
R15803 T18471 T18469 xcomp stimulated,compared
R15804 T18472 T18473 advmod GATA-3-importin,binding
R15805 T18473 T18471 oprd binding,stimulated
R15806 T18474 T18469 punct .,compared
R15807 T18475 T18476 punct (,E
R15808 T18476 T18476 ROOT E,E
R15809 T18477 T18476 punct ),E
R15810 T18478 T18479 det The,effect
R15811 T18479 T18497 nsubj effect,was
R15812 T18480 T18479 prep of,effect
R15813 T18481 T18483 amod activated,•
R15814 T18482 T18483 punct (,•
R15815 T18483 T18480 pobj •,of
R15816 T18484 T18483 punct ),•
R15817 T18485 T18483 cc versus,•
R15818 T18486 T18483 conj unstimulated,•
R15819 T18487 T18488 punct (,○
R15820 T18488 T18486 appos ○,unstimulated
R15821 T18489 T18483 punct ),•
R15822 T18490 T18479 conj GR,effect
R15823 T18491 T18490 prep on,GR
R15824 T18492 T18491 pobj attenuation,on
R15825 T18493 T18492 prep of,attenuation
R15826 T18494 T18493 pobj GATA-3,of
R15827 T18495 T18496 amod importin-α,association
R15828 T18496 T18497 nsubj association,was
R15829 T18497 T18497 ROOT was,was
R15830 T18498 T18497 acomp concentration-dependent,was
R16175 T18945 T18944 acl showing,analysis
R16176 T18946 T18959 mark that,affect
R16177 T18947 T18959 det the,affect
R16178 T18948 T18950 amod nuclear,inhibitor
R16179 T18949 T18950 compound export,inhibitor
R16180 T18950 T18959 nsubj inhibitor,affect
R16181 T18951 T18952 compound leptomycin,B
R16182 T18952 T18950 appos B,inhibitor
R16183 T18953 T18954 punct (,2
R16184 T18954 T18955 nummod 2,nM
R16185 T18955 T18952 appos nM,B
R16186 T18956 T18952 punct ),B
R16187 T18957 T18959 aux does,affect
R16188 T18958 T18959 neg not,affect
R16189 T18959 T18945 ccomp affect,showing
R16190 T18960 T18961 det the,ability
R16191 T18961 T18959 dobj ability,affect
R16192 T18962 T18961 prep of,ability
R16193 T18963 T18962 pobj FP,of
R16194 T18964 T18963 punct (,FP
R16195 T18965 T18966 nummod 10,−
R16196 T18966 T18963 appos −,FP
R16197 T18967 T18968 nummod 8,M
R16198 T18968 T18966 appos M,−
R16199 T18969 T18966 punct ),−
R16200 T18970 T18971 aux to,prevent
R16201 T18971 T18961 acl prevent,ability
R16202 T18972 T18973 compound anti-CD3,/
R16203 T18973 T18971 dobj /,prevent
R16204 T18974 T18973 nummod CD28,/
R16206 T18976 T18978 amod GATA-3,localization
R16207 T18977 T18978 amod nuclear,localization
R16208 T18978 T18975 dobj localization,stimulated
R16209 T18979 T18978 acl measured,localization
R16210 T18980 T18979 prep at,measured
R16211 T18981 T18982 nummod 60,min
R16212 T18982 T18980 pobj min,at
R16213 T18983 T18975 punct .,stimulated
R16214 T18984 T18986 compound ***,<
R16215 T18985 T18986 compound p,<
R16216 T18986 T18988 nsubj <,compared
R16217 T18987 T18986 nummod 0.001,<
R16218 T18988 T18997 prep compared,compared
R16219 T18989 T18988 prep to,compared
R16220 T18990 T18991 amod unstimulated,cells
R16221 T18991 T18989 pobj cells,to
R16222 T18992 T18997 punct ",",compared
R16223 T18993 T18995 nmod ###,<
R16224 T18994 T18995 nmod p,<
R16225 T18995 T18996 nmod <,0.001
R16226 T18996 T18997 nsubj 0.001,compared
R16227 T18997 T18997 ROOT compared,compared
R16228 T18998 T18997 prep to,compared
R16252 T19022 T19011 ccomp affect,showing
R16253 T19023 T19025 amod whole-cell,degradation
R16254 T19024 T19025 amod GATA-3,degradation
R16255 T19025 T19022 dobj degradation,affect
R16256 T19026 T19025 prep over,degradation
R16257 T19027 T19028 nummod 17,h.
R16258 T19028 T19026 pobj h.,over
R16259 T19029 T19030 punct (,C
R16260 T19030 T19028 appos C,h.
R16261 T19031 T19030 punct ),C
R16262 T19032 T19033 amod GFP-tagged,GATA-3
R16263 T19033 T19034 nsubj GATA-3,is
R16264 T19034 T19034 ROOT is,is
R16265 T19035 T19034 acomp overexpressed,is
R16266 T19036 T19035 cc and,overexpressed
R16267 T19037 T19035 conj cells,overexpressed
R16268 T19038 T19037 acl stimulated,cells
R16269 T19039 T19041 punct (,j
R16270 T19040 T19041 nmod b,j
R16271 T19041 T19038 dobj j,stimulated
R16272 T19042 T19041 punct ),j
R16273 T19043 T19038 cc or,stimulated
R16274 T19044 T19045 neg not,(
R16275 T19045 T19046 punct (,a
R16276 T19046 T19037 appos a,cells
R16277 T19047 T19046 punct ),a
R16278 T19048 T19046 prep with,a
R16279 T19049 T19050 amod anti-CD3,/
R16280 T19050 T19051 compound /,CD28
R16281 T19051 T19048 pobj CD28,with
R16282 T19052 T19034 punct .,is
R16283 T19053 T19054 det The,effect
R16284 T19054 T19079 nsubjpass effect,shown
R16285 T19055 T19054 prep of,effect
R16286 T19056 T19055 pcomp treating,of
R16287 T19057 T19056 dobj cells,treating
R16288 T19058 T19056 prep with,treating
R16289 T19059 T19058 pobj FP,with
R16290 T19060 T19062 punct (,−
R16291 T19061 T19062 nummod 10,−
R16292 T19062 T19079 npadvmod −,shown
R16293 T19063 T19062 nummod 8,−
R16294 T19064 T19079 npadvmod M,shown
R16295 T19065 T19079 punct ",",shown
R16296 T19066 T19079 nsubjpass f,shown
R16297 T19067 T19066 appos j,f
R16298 T19068 T19066 punct ),f
R16299 T19069 T19066 prep after,f
R16300 T19070 T19072 nummod 30,stimulation
R16301 T19071 T19072 compound min,stimulation
R16302 T19072 T19069 pobj stimulation,after
R16303 T19073 T19072 prep with,stimulation
R16304 T19074 T19075 amod anti-CD3,/
R16305 T19075 T19076 compound /,CD28
R16306 T19076 T19073 pobj CD28,with
R16307 T19077 T19079 auxpass is,shown
R16308 T19078 T19079 advmod also,shown
R16309 T19079 T19079 ROOT shown,shown
R16310 T19080 T19079 punct .,shown
R16311 T19081 T19084 punct (,FP
R16312 T19082 T19084 nmod D,FP
R16313 T19083 T19084 punct ),FP
R16314 T19084 T19093 nsubj FP,prevent
R16315 T19085 T19087 punct (,−
R16316 T19086 T19087 nummod 10,−
R16317 T19087 T19093 nsubj −,prevent
R16318 T19088 T19087 nummod 8,−
R16319 T19089 T19087 appos M,−
R16320 T19090 T19087 punct ),−
R16321 T19091 T19093 aux does,prevent
R16322 T19092 T19093 neg not,prevent
R16323 T19093 T19097 ccomp prevent,stimulated
R16324 T19094 T19095 compound anti-CD3,/
R16325 T19095 T19093 dobj /,prevent
R16326 T19096 T19095 nummod CD28,/
R16327 T19097 T19097 ROOT stimulated,stimulated
R16328 T19098 T19100 nummod p65,translocation
R16329 T19099 T19100 amod nuclear,translocation
R16330 T19100 T19097 dobj translocation,stimulated
R16331 T19101 T19097 prep at,stimulated
R16332 T19102 T19103 nummod 60,min
R16333 T19103 T19101 pobj min,at
R16334 T19104 T19103 prep after,min
R16335 T19105 T19104 pobj stimulation,after
R16336 T19106 T19097 punct .,stimulated
R16337 T19107 T19111 dep **,compared
R16338 T19108 T19111 nsubj p,compared
R16339 T19109 T19110 nmod <,0.01
R16340 T19110 T19108 npadvmod 0.01,p
R16341 T19111 T19111 ROOT compared,compared
R16342 T19112 T19111 prep to,compared
R16343 T19113 T19114 amod unstimulated,cells
R16344 T19114 T19112 pobj cells,to
R16345 T19115 T19111 punct .,compared
R16346 T19116 T19117 det All,results
R16347 T19117 T19118 nsubj results,are
R16348 T19118 T19118 ROOT are,are
R16349 T19119 T19118 attr representative,are
R16350 T19120 T19119 prep of,representative
R16351 T19121 T19122 advmod at,least
R16352 T19122 T19123 advmod least,four
R16353 T19123 T19125 nummod four,experiments
R16354 T19124 T19125 amod independent,experiments
R16355 T19125 T19120 pobj experiments,of
R16356 T19126 T19118 cc and,are
R16357 T19127 T19128 auxpass are,shown
R16358 T19128 T19118 conj shown,are
R16359 T19129 T19128 prep as,shown
R16360 T19130 T19132 amod mean,SEM
R16361 T19131 T19132 compound ±,SEM
R16362 T19132 T19129 pobj SEM,as
R16363 T19133 T19118 punct .,are
R16364 T19134 T19136 nsubjpass Results,analysed
R16365 T19135 T19136 auxpass were,analysed
R16366 T19136 T19136 ROOT analysed,analysed
R16367 T19137 T19136 agent by,analysed
R16368 T19138 T19137 pobj ANOVA,by
R16369 T19139 T19136 acl followed,analysed
R16370 T19140 T19139 agent by,followed
R16371 T19141 T19142 compound Newman-Keuls,test
R16372 T19142 T19140 pobj test,by
R16373 T19143 T19136 punct .,analysed
R16592 T19430 T19431 compound Fluticasone,propionate
R16593 T19431 T19432 nsubj propionate,impairs
R16594 T19432 T19432 ROOT impairs,impairs
R16595 T19433 T19434 amod GATA-3,interaction
R16596 T19434 T19432 dobj interaction,impairs
R16597 T19435 T19434 prep with,interaction
R16598 T19436 T19440 amod importin-α,localization
R16599 T19437 T19436 cc and,importin-α
R16600 T19438 T19436 conj GATA-3,importin-α
R16601 T19439 T19440 amod nuclear,localization
R16602 T19440 T19435 pobj localization,with
R16603 T19441 T19440 prep in,localization
R16604 T19442 T19441 pobj vivo,in
R16605 T19443 T19442 cc and,vivo
R16606 T19444 T19445 dep ex,vivo
R16607 T19445 T19442 conj vivo,vivo
R16608 T19446 T19432 punct .,impairs
R16609 T19447 T19448 punct (,A
R16610 T19448 T19448 ROOT A,A
R16611 T19449 T19448 cc and,A
R16612 T19450 T19453 nmod B,analysis
R16613 T19451 T19450 punct ),B
R16614 T19452 T19453 compound Co-immunoprecipitation,analysis
R16615 T19453 T19465 nsubj analysis,demonstrated
R16616 T19454 T19453 prep of,analysis
R16617 T19455 T19454 pobj PBMCs,of
R16618 T19456 T19455 prep from,PBMCs
R16619 T19457 T19459 amod steroid-naïve,patients
R16620 T19458 T19459 compound asthma,patients
R16621 T19459 T19456 pobj patients,from
R16622 T19460 T19459 acl treated,patients
R16623 T19461 T19460 prep with,treated
R16624 T19462 T19461 pobj FP,with
R16625 T19463 T19460 prep in,treated
R16626 T19464 T19463 pobj vitro,in
R16627 T19465 T19448 conj demonstrated,A
R16628 T19466 T19467 amod impaired,interaction
R16629 T19467 T19465 dobj interaction,demonstrated
R16630 T19468 T19467 prep between,interaction
R16631 T19469 T19468 pobj GATA-3,between
R16632 T19470 T19469 cc and,GATA-3
R16633 T19471 T19469 conj importin-α,GATA-3
R16634 T19472 T19465 conj measured,demonstrated
R16635 T19473 T19472 prep at,measured
R16636 T19474 T19475 nummod 60,min
R16637 T19475 T19473 pobj min,at
R16638 T19476 T19465 punct .,demonstrated
R16639 T19477 T19478 det Each,bar
R16640 T19478 T19479 nsubj bar,represents
R16641 T19479 T19479 ROOT represents,represents
R16642 T19480 T19483 det the,SEM
R16643 T19481 T19483 amod mean,SEM
R16644 T19482 T19483 compound ±,SEM
R16645 T19483 T19479 dobj SEM,represents
R16646 T19484 T19483 prep of,SEM
R16647 T19485 T19486 advmod at,least
R16648 T19486 T19487 advmod least,three
R16649 T19487 T19489 nummod three,experiments
R16650 T19488 T19489 amod independent,experiments
R16651 T19489 T19484 pobj experiments,of
R16652 T19490 T19483 punct ;,SEM
R16653 T19491 T19493 nmod ***,<
R16654 T19492 T19493 nmod p,<
R16655 T19493 T19494 nmod <,0.001
R16656 T19494 T19483 appos 0.001,SEM
R16657 T19495 T19494 prep compared,0.001
R16658 T19496 T19495 prep with,compared
R16659 T19497 T19496 pobj control,with
R16660 T19498 T19499 mark as,determined
R16661 T19499 T19494 advcl determined,0.001
R16662 T19500 T19499 agent by,determined
R16663 T19501 T19502 compound ANOVA/Newman-Keuls,analysis
R16664 T19502 T19500 pobj analysis,by
R16665 T19503 T19479 punct .,represents
R16666 T19504 T19505 punct (,C
R16667 T19505 T19505 ROOT C,C
R16668 T19506 T19505 cc and,C
R16669 T19507 T19505 conj D,C
R16670 T19508 T19505 punct ),C
R16671 T19509 T19510 compound Co-immunoprecipitation,analyses
R16672 T19510 T19530 nsubj analyses,demonstrated
R16673 T19511 T19510 prep of,analyses
R16674 T19512 T19511 pobj PBMCs,of
R16675 T19513 T19512 prep from,PBMCs
R16676 T19514 T19516 amod steroid-naïve,patients
R16677 T19515 T19516 compound asthma,patients
R16678 T19516 T19513 pobj patients,from
R16679 T19517 T19516 acl treated,patients
R16680 T19518 T19517 prep with,treated
R16681 T19519 T19520 amod inhaled,FP
R16682 T19520 T19518 pobj FP,with
R16683 T19521 T19520 punct (,FP
R16684 T19522 T19523 nummod 500,µg
R16685 T19523 T19520 appos µg,FP
R16686 T19524 T19517 prep via,treated
R16687 T19525 T19526 det a,spacer
R16688 T19526 T19524 pobj spacer,via
R16689 T19527 T19517 punct ),treated
R16690 T19528 T19517 prep in,treated
R16691 T19529 T19528 pobj vivo,in
R16692 T19530 T19530 ROOT demonstrated,demonstrated
R16693 T19531 T19532 amod decreased,association
R16694 T19532 T19530 dobj association,demonstrated
R16695 T19533 T19532 prep between,association
R16696 T19534 T19533 pobj GATA-3,between
R16697 T19535 T19534 cc and,GATA-3
R16698 T19536 T19534 conj importin-α,GATA-3
R16699 T19537 T19530 punct .,demonstrated
R16700 T19538 T19540 det The,values
R16701 T19539 T19540 amod individual,values
R16702 T19540 T19545 nsubjpass values,presented
R16703 T19541 T19540 prep for,values
R16704 T19542 T19543 det each,treatment
R16705 T19543 T19541 pobj treatment,for
R16706 T19544 T19545 auxpass are,presented
R16707 T19545 T19545 ROOT presented,presented
R16708 T19546 T19545 advmod graphically,presented
R16709 T19547 T19545 punct .,presented
R16710 T19548 T19554 punct (,showing
R16711 T19549 T19553 nmod E,blot
R16712 T19550 T19549 punct ),E
R16713 T19551 T19553 compound Representative,blot
R16714 T19552 T19553 compound Western,blot
R16715 T19553 T19554 nsubj blot,showing
R16716 T19554 T19554 ROOT showing,showing
R16717 T19555 T19559 mark that,unaffected
R16718 T19556 T19557 amod importin-α,expression
R16719 T19557 T19559 nsubjpass expression,unaffected
R16720 T19558 T19559 auxpass was,unaffected
R16721 T19559 T19554 ccomp unaffected,showing
R16722 T19560 T19559 prep by,unaffected
R16723 T19561 T19560 pobj inhalation,by
R16724 T19562 T19561 prep of,inhalation
R16725 T19563 T19562 pobj FP,of
R16726 T19564 T19554 punct .,showing
R16727 T19565 T19566 nsubj Blot,is
R16728 T19566 T19566 ROOT is,is
R16729 T19567 T19566 attr representative,is
R16730 T19568 T19567 prep of,representative
R16731 T19569 T19568 pobj gels,of
R16732 T19570 T19567 prep from,representative
R16733 T19571 T19572 nummod three,participants
R16734 T19572 T19570 pobj participants,from
R16735 T19573 T19566 punct .,is
R17076 T19983 T19985 amod Inhaled,propionate
R17077 T19984 T19985 compound fluticasone,propionate
R17078 T19985 T19986 nsubj propionate,impairs
R17079 T19986 T19986 ROOT impairs,impairs
R17080 T19987 T19989 amod GATA-3,localization
R17081 T19988 T19989 amod nuclear,localization
R17082 T19989 T19986 dobj localization,impairs
R17083 T19990 T19989 prep in,localization
R17084 T19991 T19990 pobj PBMCs,in
R17085 T19992 T19986 punct .,impairs
R17086 T19993 T19993 ROOT (,(
R17087 T19994 T19993 dep A,(
R17088 T19995 T19994 punct ),A
R17089 T19996 T19997 compound Representative,immunocytochemistry
R17090 T19997 T19997 ROOT immunocytochemistry,immunocytochemistry
R17091 T19998 T19997 prep of,immunocytochemistry
R17092 T19999 T19998 pcomp showing,of
R17093 T20000 T20001 det the,effect
R17094 T20001 T19999 dobj effect,showing
R17095 T20002 T20001 prep of,effect
R17096 T20003 T20004 amod inhaled,FP
R17097 T20004 T20002 pobj FP,of
R17098 T20005 T20007 punct (,µg
R17099 T20006 T20007 nummod 500,µg
R17100 T20007 T20004 appos µg,FP
R17122 T20029 T20030 nummod 2,h
R17123 T20030 T20031 amod h,following
R17124 T20031 T20021 prep following,immunoreactivity
R17125 T20032 T20034 amod inhaled,treatment
R17126 T20033 T20034 compound FP,treatment
R17127 T20034 T20031 dobj treatment,following
R17128 T20035 T20034 punct (,treatment
R17129 T20036 T20039 nummod 100,µg
R17130 T20037 T20036 cc or,100
R17131 T20038 T20036 conj 500,100
R17132 T20039 T20034 appos µg,treatment
R17133 T20040 T20039 prep via,µg
R17134 T20041 T20040 pobj spacer,via
R17135 T20042 T20034 punct ),treatment
R17136 T20043 T20021 punct .,immunoreactivity
R17137 T20044 T20048 det The,ranges
R17138 T20045 T20048 amod median,ranges
R17139 T20046 T20045 cc and,median
R17140 T20047 T20045 conj interquartile,median
R17141 T20048 T20053 nsubjpass ranges,presented
R17142 T20049 T20048 prep for,ranges
R17143 T20050 T20051 det each,treatment
R17144 T20051 T20049 pobj treatment,for
R17145 T20052 T20053 auxpass are,presented
R17146 T20053 T20053 ROOT presented,presented
R17147 T20054 T20053 prep as,presented
R17148 T20055 T20057 det a,plot
R17149 T20056 T20057 compound box-and-whiskers,plot
R17150 T20057 T20054 pobj plot,as
R17151 T20058 T20061 punct (,7
R17152 T20059 T20061 advmod n,7
R17153 T20060 T20061 punct =,7
R17154 T20061 T20057 appos 7,plot
R17155 T20062 T20061 punct ),7
R17156 T20063 T20053 punct ;,presented
R17200 T20107 T20110 nsubj analyses,demonstrated
R17201 T20108 T20107 prep of,analyses
R17202 T20109 T20108 pobj PBMCs,of
R17203 T20110 T20110 ROOT demonstrated,demonstrated
R17204 T20111 T20113 det a,decrease
R17205 T20112 T20113 amod dose-dependent,decrease
R17206 T20113 T20110 dobj decrease,demonstrated
R17207 T20114 T20113 prep in,decrease
R17208 T20115 T20116 amod nuclear,expression
R17209 T20116 T20114 pobj expression,in
R17210 T20117 T20116 prep of,expression
R17211 T20118 T20117 pobj GATA-3,of
R17212 T20119 T20110 punct ",",demonstrated
R17213 T20120 T20110 cc and,demonstrated
R17214 T20121 T20110 conj increased,demonstrated
R17215 T20122 T20124 amod cytoplasmic,expression
R17216 T20123 T20124 amod GATA-3,expression
R17217 T20124 T20121 dobj expression,increased
R17218 T20125 T20126 nummod 2,h
R17219 T20126 T20124 appos h,expression
R17220 T20127 T20126 prep after,h
R17221 T20128 T20127 pobj inhalation,after
R17222 T20129 T20128 prep of,inhalation
R17223 T20130 T20129 pobj FP,of
R17224 T20131 T20110 punct .,demonstrated
R17225 T20132 T20133 compound Histone,H1
R17226 T20133 T20137 nsubj H1,confirmed
R17227 T20134 T20133 cc and,H1
R17228 T20135 T20133 conj MEK-1,H1
R17229 T20136 T20137 nsubj immunoblotting,confirmed
R17230 T20137 T20137 ROOT confirmed,confirmed
R17231 T20138 T20141 amod equivalent,loading
R17232 T20139 T20140 amod total,protein
R17233 T20140 T20141 compound protein,loading
R17234 T20141 T20137 dobj loading,confirmed
R17235 T20142 T20141 prep for,loading
R17236 T20143 T20147 det the,fractions
R17279 T20186 T20186 ROOT compared,compared
R17280 T20187 T20188 aux to,control
R17281 T20188 T20186 xcomp control,compared
R17282 T20189 T20164 punct .,shown
R17283 T20190 T20198 punct (,demonstrated
R17284 T20191 T20195 nmod E,analyses
R17285 T20192 T20191 punct ),E
R17286 T20193 T20195 amod Western,analyses
R17287 T20194 T20195 compound blot,analyses
R17288 T20195 T20198 nsubj analyses,demonstrated
R17289 T20196 T20195 prep of,analyses
R17290 T20197 T20196 pobj PBMCs,of
R17291 T20198 T20198 ROOT demonstrated,demonstrated
R17292 T20199 T20201 det a,decrease
R17293 T20200 T20201 amod time-dependent,decrease
R17294 T20201 T20198 dobj decrease,demonstrated
R17295 T20202 T20201 prep in,decrease
R17296 T20203 T20204 amod dual,phosphorylation
R17297 T20204 T20202 pobj phosphorylation,in
R17298 T20205 T20206 punct (,threonine-180
R17299 T20206 T20204 appos threonine-180,phosphorylation
R17300 T20207 T20206 cc and,threonine-180
R17301 T20208 T20206 conj tyrosine-182,threonine-180
R17302 T20209 T20206 punct ),threonine-180
R17303 T20210 T20206 prep of,threonine-180
R17304 T20211 T20212 nummod p38,MAPK
R17305 T20212 T20210 pobj MAPK,of
R17306 T20213 T20198 prep after,demonstrated
R17307 T20214 T20213 pobj inhalation,after
R17308 T20215 T20214 prep of,inhalation
R17309 T20216 T20215 pobj FP,of
R17310 T20217 T20219 punct (,µg
R17311 T20218 T20219 nummod 500,µg
R17312 T20219 T20216 appos µg,FP
R17313 T20220 T20219 punct ),µg
R17314 T20221 T20198 punct .,demonstrated
R17321 T20228 T20223 punct ),results
R17322 T20229 T20229 ROOT are,are
R17323 T20230 T20229 attr representative,are
R17324 T20231 T20230 prep of,representative
R17325 T20232 T20231 pobj samples,of
R17326 T20233 T20232 prep from,samples
R17327 T20234 T20235 nummod two,participants
R17328 T20235 T20233 pobj participants,from
R17329 T20236 T20229 punct .,are
R434 T611 T612 amod nuclear,transport
R435 T612 T610 pobj transport,for
R437 T613 T610 prep through,for
R438 T614 T616 det the,importer
R439 T615 T616 amod nuclear,importer
R440 T616 T613 pobj importer,through
R441 T617 T609 conj importin-α,receptor
R442 T618 T574 punct .,demonstrated
R443 T619 T623 prep In,induces
R445 T620 T619 pobj addition,In
R505 T652 T623 punct .,induces
R507 T653 T655 det These,effects
R509 T654 T655 amod inhibitory,effects
R510 T655 T658 nsubj effects,are
R513 T656 T655 prep of,effects
R515 T657 T656 pobj fluticasone,of
R516 T658 T658 ROOT are,are
R517 T659 T658 acomp rapid,are
R519 T660 T659 punct ",",rapid
R520 T661 T659 conj potent,rapid
R521 T662 T658 punct ",",are
R523 T663 T658 cc and,are
R524 T664 T658 conj prolonged,are
R525 T665 T658 punct .,are
R527 T666 T668 nsubj We,demonstrated
R528 T667 T668 advmod also,demonstrated
R530 T668 T668 ROOT demonstrated,demonstrated
R531 T669 T672 mark that,inhibits
R532 T670 T671 amod inhaled,fluticasone
R533 T671 T672 nsubj fluticasone,inhibits
R535 T672 T668 ccomp inhibits,demonstrated
R536 T673 T675 amod GATA-3,translocation
R538 T674 T675 amod nuclear,translocation
R539 T675 T672 dobj translocation,inhibits
R540 T676 T675 prep in,translocation
R542 T677 T679 amod peripheral,lymphocytes
R543 T678 T679 compound blood,lymphocytes
R544 T679 T676 pobj lymphocytes,in
R546 T680 T679 prep of,lymphocytes
R547 T681 T680 pobj patients,of
R549 T682 T672 prep with,inhibits
R554 T683 T682 pobj asthma,with
R555 T684 T683 prep in,asthma
R557 T685 T684 pobj vivo,in
R558 T686 T668 punct .,demonstrated
R559 T687 T688 compound Conclusions,Corticosteroids
R560 T688 T689 nsubj Corticosteroids,have
R561 T689 T689 ROOT have,have
R563 T690 T693 det a,effect
R564 T691 T693 amod potent,effect
R566 T692 T693 amod inhibitory,effect
R567 T693 T689 dobj effect,have
R568 T694 T693 prep on,effect
R570 T695 T694 pobj GATA-3,on
R571 T696 T689 prep via,have
R576 T697 T699 nummod two,mechanisms
R578 T698 T699 amod interacting,mechanisms
R579 T699 T696 pobj mechanisms,via
R580 T700 T702 nsubj that,suppress
R582 T701 T702 advmod potently,suppress
R583 T702 T699 relcl suppress,mechanisms
R585 T703 T705 amod Th2,expression
R586 T704 T705 amod cytokine,expression
R587 T705 T702 dobj expression,suppress
R589 T706 T689 punct .,have
R590 T707 T709 det This,mechanism
R591 T708 T709 amod novel,mechanism
R593 T709 T715 nsubj mechanism,account
R594 T710 T709 prep of,mechanism
R595 T711 T710 pobj action,of
R597 T712 T711 prep of,action
R598 T713 T712 pobj corticosteroids,of
R599 T714 T715 aux may,account
R601 T715 T715 ROOT account,account
R602 T716 T715 prep for,account
R2703 T3016 T3015 prep of,inhibition
R2705 T3017 T3018 amod Th2,cytokines
R2706 T3018 T3016 pobj cytokines,of
R2707 T3038 T3021 advcl have,is
R2708 T3019 T3015 prep by,inhibition
R2709 T3020 T3019 pobj corticosteroids,by
R2710 T3021 T3021 ROOT is,is
R2711 T3022 T3021 neg not,is
R2712 T3039 T3042 det any,sequence
R2713 T3023 T3024 advmod well,understood
R2714 T3024 T3021 acomp understood,is
R2715 T3040 T3042 amod recognisable,sequence
R2716 T3025 T3021 punct ",",is
R2717 T3026 T3038 mark because,have
R2718 T3027 T3028 det the,genes
R2719 T3041 T3042 compound GRE,sequence
R2720 T3028 T3038 nsubj genes,have
R2721 T3029 T3028 acl encoding,genes
R2722 T3030 T3029 dobj IL-4,encoding
R2723 T3042 T3038 dobj sequence,have
R2724 T3031 T3030 punct ",",IL-4
R2725 T3032 T3030 conj IL-5,IL-4
R2726 T3033 T3032 punct ",",IL-5
R2727 T3043 T3045 nmod [,]
R2728 T3034 T3029 cc and,encoding
R2729 T3035 T3038 nsubj IL-13,have
R2730 T3036 T3038 aux do,have
R2731 T3037 T3038 neg not,have
R2732 T3044 T3045 nummod 29,]
R2733 T3045 T3042 appos ],sequence
R2734 T3046 T3038 cc and,have
R2735 T3047 T3050 auxpass are,regulated
R2736 T3048 T3050 advmod only,regulated
R2738 T3049 T3050 advmod partly,regulated
R2741 T3050 T3038 conj regulated,have
R2745 T3051 T3050 agent by,regulated
R2750 T3052 T3051 pobj NF-κB,by
R2753 T3053 T3050 prep in,regulated
R2758 T3054 T3055 amod human,cells
R2762 T3055 T3053 pobj cells,in
R2765 T3056 T3058 nmod [,]
R2769 T3057 T3058 nummod 30,]
R2773 T3058 T3055 appos ],cells
R2776 T3059 T3055 appos [,cells
R2783 T3060 T3061 nummod 32,]
R2787 T3061 T3059 appos ],[
R2791 T3062 T3021 punct .,is
R2792 T3063 T3076 advcl Using,shown
R2794 T3064 T3063 dobj overexpression,Using
R2797 T3065 T3064 cc and,overexpression
R2801 T3066 T3067 amod CAT-reporter,genes
R2805 T3067 T3064 conj genes,overexpression
R2809 T3068 T3067 punct ",",genes
R2813 T3069 T3076 nsubj Lavender,shown
R2817 T3070 T3069 cc and,Lavender
R2821 T3071 T3069 conj colleagues,Lavender
R2824 T3072 T3074 nmod [,]
R2825 T3073 T3074 nummod 33,]
R2826 T3074 T3071 appos ],colleagues
R2827 T3075 T3076 aux have,shown
R2828 T3076 T3076 ROOT shown,shown
R2829 T3077 T3079 mark that,reduced
R2830 T3078 T3079 nsubj GR,reduced
R2831 T3079 T3076 ccomp reduced,shown
R2832 T3080 T3081 amod GATA-3-mediated,IL-5
R2833 T3081 T3079 dobj IL-5,reduced
R2834 T3082 T3079 cc and,reduced
R2849 T3097 T3098 amod local,recruitment
R2850 T3098 T3102 nsubj recruitment,alter
R2851 T3099 T3098 prep of,recruitment
R2852 T3100 T3099 pobj GR,of
R2853 T3101 T3102 aux may,alter
R2854 T3102 T3095 ccomp alter,postulated
R2855 T3103 T3104 det the,ability
R2856 T3104 T3102 dobj ability,alter
R2857 T3105 T3104 prep of,ability
R2858 T3106 T3105 pobj GATA-3,of
R2859 T3107 T3109 preconj either,bind
R2860 T3108 T3109 aux to,bind
R2861 T3109 T3104 conj bind,ability
R2862 T3110 T3102 prep to,alter
R2863 T3111 T3113 poss its,site
R2864 T3112 T3113 compound target,site
R2865 T3113 T3110 pobj site,to
R2866 T3114 T3102 punct ",",alter
R2867 T3115 T3116 aux to,cause
R2868 T3116 T3102 advcl cause,alter
R2869 T3117 T3118 amod transcriptional,up-regulation
R2870 T3118 T3116 dobj up-regulation,cause
R2871 T3119 T3118 punct ",",up-regulation
R2872 T3120 T3116 cc or,cause
R2873 T3121 T3122 aux to,maintain
R2874 T3122 T3116 conj maintain,cause
R2875 T3123 T3124 det an,environment
R2876 T3124 T3122 dobj environment,maintain
R2877 T3125 T3126 nsubj that,is
R2878 T3126 T3124 relcl is,environment
R2879 T3127 T3126 acomp permissive,is
R2880 T3128 T3127 prep for,permissive
R2737 T3135 T3133 dobj effects,investigated
R2739 T3136 T3135 prep of,effects
R2740 T3137 T3139 det a,corticosteroid
R2742 T3138 T3139 amod synthetic,corticosteroid
R2743 T3139 T3136 pobj corticosteroid,of
R2744 T3140 T3139 punct ",",corticosteroid
R2746 T3141 T3139 appos FP,corticosteroid
R2747 T3142 T3139 punct ",",corticosteroid
R2748 T3143 T3135 prep on,effects
R2749 T3144 T3145 amod GATA-3,phosphorylation
R2751 T3145 T3143 pobj phosphorylation,on
R2752 T3146 T3145 cc and,phosphorylation
R2754 T3147 T3148 amod nuclear,translocation
R2755 T3148 T3145 conj translocation,phosphorylation
R2756 T3149 T3135 prep in,effects
R2757 T3150 T3154 det a,line
R2759 T3151 T3154 compound T,line
R2760 T3152 T3154 compound lymphocyte,line
R2761 T3153 T3154 compound cell,line
R2763 T3154 T3149 pobj line,in
R2764 T3155 T3156 punct (,HuT-78
R2766 T3156 T3154 appos HuT-78,line
R2767 T3157 T3156 punct ),HuT-78
R2768 T3158 T3149 cc and,in
R2770 T3159 T3149 conj in,in
R2771 T3160 T3163 amod peripheral,cells
R2772 T3161 T3162 compound blood,mononuclear
R2774 T3162 T3163 compound mononuclear,cells
R2775 T3163 T3159 pobj cells,in
R2777 T3164 T3163 acl activated,cells
R2778 T3165 T3164 agent by,activated
R2779 T3166 T3169 amod anti-CD3,antibodies
R779 T454 T473 npadvmod Suppression,plays
R780 T455 T454 prep of,Suppression
R781 T456 T458 compound GATA-3,Import
R782 T457 T458 compound Nuclear,Import
R783 T458 T455 pobj Import,of
R388 T491 T490 punct ",",IL-5
R389 T492 T490 cc and,IL-5
R390 T493 T490 conj IL-13,IL-5
R391 T494 T490 prep from,IL-5
R392 T495 T496 compound T,helper-2
R393 T496 T494 pobj helper-2,from
R394 T497 T496 punct (,helper-2
R395 T498 T496 appos Th2,helper-2
R396 T499 T496 punct ),helper-2
R397 T500 T494 pobj cells,from
R399 T501 T473 cc and,plays
R402 T502 T503 advmod therefore,is
R406 T503 T473 conj is,plays
R407 T504 T506 det a,mediator
R408 T505 T506 amod key,mediator
R409 T506 T503 attr mediator,is
R410 T507 T506 prep of,mediator
R411 T508 T509 amod allergic,diseases
R412 T509 T507 pobj diseases,of
R413 T510 T473 punct .,plays
R417 T511 T512 nsubj Corticosteroids,are
R420 T512 T512 ROOT are,are
R424 T513 T514 advmod highly,effective
R427 T514 T512 acomp effective,are
R431 T515 T514 prep in,effective
R414 T596 T595 acomp due,is
R415 T597 T595 punct ",",is
R416 T598 T595 prep in,is
R418 T599 T598 pobj part,in
R419 T600 T595 punct ",",is
R421 T601 T577 prep to,inhibits
R422 T602 T601 pobj competition,to
R423 T603 T602 prep between,competition
R425 T604 T603 pobj GATA-3,between
R426 T605 T604 cc and,GATA-3
R428 T606 T609 det the,receptor
R429 T607 T609 amod ligand-activated,receptor
R430 T608 T609 compound glucocorticoid,receptor
R432 T609 T604 conj receptor,GATA-3
R433 T610 T609 prep for,receptor
R626 T728 T726 pobj diseases,of
R627 T729 T715 punct .,account
R628 T730 T731 intj Please,see
R629 T731 T731 ROOT see,see
R630 T732 T731 advmod later,see
R631 T733 T732 prep in,later
R633 T734 T735 det the,article
R634 T735 T733 pobj article,in
R635 T736 T735 prep for,article
R636 T737 T739 poss Editors,Summary
R638 T738 T737 case ',Editors
R639 T739 T736 pobj Summary,for
R1967 T2279 T2293 nsubjpass Inflammation,mediated
R1968 T2280 T2279 prep in,Inflammation
R1969 T2281 T2282 amod allergic,diseases
R1970 T2282 T2280 pobj diseases,in
R1971 T2283 T2284 amod such,as
R1972 T2284 T2282 prep as,diseases
R1973 T2285 T2284 pobj asthma,as
R1974 T2286 T2285 punct ",",asthma
R1975 T2287 T2285 conj rhinitis,asthma
R1976 T2288 T2287 punct ",",rhinitis
R2339 T2666 T2665 pcomp phosphorylating,in
R2340 T2667 T2666 dobj GATA-3,phosphorylating
R2342 T2668 T2669 aux to,enhance
R2343 T2669 T2661 advcl enhance,plays
R2344 T2670 T2671 poss its,interaction
R2346 T2671 T2669 dobj interaction,enhance
R2347 T2672 T2671 prep with,interaction
R2348 T2673 T2676 amod importin-α,transport
R2349 T2674 T2673 cc and,importin-α
R2351 T2675 T2673 conj subsequent,importin-α
R2352 T2676 T2672 pobj transport,with
R2354 T2677 T2669 prep into,enhance
R2355 T2678 T2679 det the,nucleus
R2356 T2679 T2677 pobj nucleus,into
R3379 T3897 T3898 auxpass was,taken
R3380 T3898 T3886 advcl taken,given
R3381 T3899 T3898 prep for,taken
R3382 T3900 T3899 pobj preparation,for
R3383 T3901 T3900 prep of,preparation
R3384 T3902 T3901 pobj PBMCs,of
R3385 T3903 T3898 prep at,taken
R3386 T3904 T3903 pobj 1,at
R3387 T3905 T3898 cc and,taken
R3388 T3906 T3907 nummod 2,h
R3603 T4168 T4164 punct ),Oxford
R3717 T4282 T4284 nsubjpass reagents,purchased
R3718 T4283 T4284 auxpass were,purchased
R3719 T4284 T4284 ROOT purchased,purchased
R3720 T4285 T4284 prep from,purchased
R3721 T4286 T4285 pobj Sigma,from
R3722 T4287 T4288 punct (,Poole
R3723 T4288 T4284 npadvmod Poole,purchased
R3724 T4289 T4288 punct ",",Poole
R3725 T4290 T4288 appos UK,Poole
R3726 T4291 T4288 punct ),Poole
R4112 T4768 T4764 dobj virus,using
R4113 T4769 T4771 nmod RT,Promega
R4114 T4770 T4771 punct (,Promega
R4115 T4771 T4768 appos Promega,virus
R4116 T4772 T4771 punct ",",Promega
R4117 T4773 T4771 conj Southampton,Promega
R4118 T4774 T4773 punct ",",Southampton
R4119 T4775 T4773 conj UK,Southampton
R4120 T4776 T4771 punct ),Promega
R4121 T4777 T4763 punct .,transcribed
R4122 T4778 T4784 prep For,carried
R4123 T4779 T4780 amod relative,quantification
R4124 T4780 T4778 pobj quantification,For
R4125 T4781 T4784 punct ",",carried
R4126 T4782 T4784 nsubjpass RT-PCR,carried
R4127 T4783 T4784 auxpass was,carried
R4128 T4784 T4784 ROOT carried,carried
R4129 T4785 T4784 prt out,carried
R4130 T4786 T4784 advcl using,carried
R4131 T4787 T4788 compound cDNA,probes
R4132 T4788 T4786 dobj probes,using
R4133 T4789 T4784 punct .,carried
R4362 T5053 T5054 compound [,pH
R4363 T5054 T5048 appos pH,P-40
R4364 T5055 T5056 nummod 7.5,]
R4365 T5056 T5056 ROOT ],]
R4366 T5057 T5056 punct ",",]
R4367 T5058 T5060 nummod 150,NaCl
R4368 T5059 T5060 compound mM,NaCl
R4369 T5060 T5056 appos NaCl,]
R4370 T5061 T5056 punct ),]
R4371 T5062 T5056 prep in,]
R4372 T5063 T5064 det the,presence
R4373 T5064 T5062 pobj presence,in
R4374 T5065 T5064 prep of,presence
R4375 T5066 T5069 amod complete,inhibitor
R4376 T5067 T5069 compound protease,inhibitor
R4377 T5068 T5069 compound cocktail,inhibitor
R4378 T5069 T5065 pobj inhibitor,of
R4379 T5070 T5039 punct .,prepared
R4380 T5071 T5073 nsubjpass Lysates,centrifuged
R4381 T5072 T5073 auxpass were,centrifuged
R4382 T5073 T5073 ROOT centrifuged,centrifuged
R4383 T5074 T5073 prep at,centrifuged
R4384 T5075 T5076 nummod 4,°
R4385 T5076 T5074 pobj °,at
R4386 T5077 T5073 conj C,centrifuged
R4387 T5078 T5077 prep for,C
R4388 T5079 T5080 nummod 10,min
R4389 T5080 T5078 pobj min,for
R4390 T5081 T5080 prep at,min
R4391 T5082 T5083 nummod "12,000",rpm
R4392 T5083 T5081 pobj rpm,at
R4393 T5084 T5073 prep in,centrifuged
R4394 T5085 T5087 det an,microcentrifuge
R4395 T5086 T5087 compound Eppendorf,microcentrifuge
R4396 T5087 T5084 pobj microcentrifuge,in
R4397 T5088 T5089 aux to,remove
R4398 T5089 T5073 advcl remove,centrifuged
R4399 T5090 T5091 amod cellular,debris
R4400 T5091 T5089 dobj debris,remove
R4401 T5092 T5073 punct .,centrifuged
R4402 T5093 T5096 nsubjpass Samples,immunoprecipitated
R4403 T5094 T5096 auxpass were,immunoprecipitated
R4404 T5095 T5096 advmod then,immunoprecipitated
R4405 T5096 T5096 ROOT immunoprecipitated,immunoprecipitated
R4406 T5097 T5096 prep with,immunoprecipitated
R4407 T5098 T5100 preconj either,µl
R4408 T5099 T5100 nummod 10,µl
R4409 T5100 T5107 nsubj µl,using
R4410 T5101 T5100 prep of,µl
R4411 T5102 T5101 pobj antibody,of
R4412 T5103 T5102 prep against,antibody
R4413 T5104 T5103 pobj GATA-3,against
R4414 T5105 T5104 cc or,GATA-3
R4416 T5107 T5097 pcomp using,with
R4417 T5108 T5110 nmod A/G,slurry
R4418 T5109 T5110 amod agarose,slurry
R4419 T5110 T5107 dobj slurry,using
R4420 T5111 T5107 prep in,using
R4421 T5112 T5113 det the,presence
R4422 T5113 T5111 pobj presence,in
R4423 T5114 T5113 prep of,presence
R4424 T5115 T5116 amod protease,inhibitor
R4425 T5116 T5114 pobj inhibitor,of
R4426 T5117 T5107 advcl using,using
R4427 T5118 T5119 det the,Catch
R4428 T5119 T5117 dobj Catch,using
R4429 T5120 T5119 cc and,Catch
R4430 T5121 T5119 conj Release,Catch
R4431 T5122 T5119 conj methodology,Catch
R4432 T5123 T5125 punct (,Biotechnology
R4433 T5124 T5125 compound Upstate,Biotechnology
R4434 T5125 T5119 conj Biotechnology,Catch
R4435 T5126 T5125 punct ",",Biotechnology
R4436 T5127 T5128 compound Lake,Placid
R4437 T5128 T5125 conj Placid,Biotechnology
R4974 T5758 T5755 pobj Assay,In
R4975 T5759 T5758 prep for,Assay
R4668 T5393 T5395 punct ′,TCATGGCTCTGAAACGTTCTG-3
R4669 T5394 T5395 punct -,TCATGGCTCTGAAACGTTCTG-3
R4670 T5395 T5396 compound TCATGGCTCTGAAACGTTCTG-3,′
R4671 T5396 T5388 appos ′,′
R4672 T5397 T5368 punct .,detected
R4673 T5398 T5400 nsubjpass PCR,performed
R4674 T5399 T5400 auxpass was,performed
R4675 T5400 T5400 ROOT performed,performed
R4676 T5401 T5400 advcl using,performed
R4677 T5402 T5406 det a,cycler
R4678 T5403 T5404 nmod Hybaid,Omnigene
R4679 T5404 T5406 nmod Omnigene,cycler
R4680 T5405 T5406 amod thermal,cycler
R4681 T5406 T5401 dobj cycler,using
R4682 T5407 T5408 punct (,Hybaid
R4683 T5408 T5406 appos Hybaid,cycler
R4684 T5409 T5408 punct ",",Hybaid
R4685 T5410 T5408 npadvmod Ashford,Hybaid
R4686 T5411 T5410 punct ",",Ashford
R5070 T5854 T5853 pobj 96-well,to
R5076 T5860 T5857 pobj antibody,with
R5077 T5861 T5852 punct .,added
R5078 T5862 T5880 prep After,added
R5079 T5863 T5865 nummod 1,incubation
R5080 T5864 T5865 compound h,incubation
R5081 T5865 T5862 pobj incubation,After
R5082 T5866 T5880 punct ",",added
R5083 T5867 T5880 nsubjpass GATA-3,added
R5084 T5868 T5870 punct (,ng/ml
R5180 T5964 T5963 pobj GATA-3,of
R5181 T5965 T5959 punct ",",used
R5182 T5966 T5959 cc and,used
R5183 T5967 T5968 compound rhodamine,donkey
R5184 T5968 T5981 nsubjpass donkey,used
R5185 T5969 T5970 compound anti-mouse,IgG
R5186 T5970 T5981 nsubjpass IgG,used
R5187 T5971 T5972 punct (,Novus
R5188 T5972 T5970 appos Novus,IgG
R5189 T5973 T5972 punct ",",Novus
R5190 T5974 T5972 npadvmod Littleton,Novus
R5191 T5975 T5974 punct ",",Littleton
R5192 T5976 T5974 conj Colorado,Littleton
R5193 T5977 T5976 punct ",",Colorado
R5194 T5978 T5976 conj USA,Colorado
R5195 T5979 T5976 punct ),Colorado
R5196 T5980 T5981 auxpass was,used
R5197 T5981 T5959 conj used,used
R5198 T5982 T5981 prep for,used
R5199 T5983 T5984 det the,detection
R5200 T5984 T5982 pobj detection,for
R5201 T5985 T5984 prep of,detection
R5202 T5986 T5985 pobj GR,of
R5203 T5987 T5981 punct .,used
R5204 T5988 T5991 nmod FITC,levels
R5205 T5989 T5988 cc and,FITC
R5206 T5990 T5988 conj rhodamine,FITC
R5314 T6171 T6170 advcl using,determined
R5315 T6172 T6174 det an,kit
R5316 T6173 T6174 amod ELISA-based,kit
R5317 T6174 T6171 dobj kit,using
R5318 T6175 T6174 punct (,kit
R5319 T6176 T6177 amod Trans-AM,p65
R5320 T6177 T6174 appos p65,kit
R5321 T6178 T6177 punct ",",p65
R5322 T6179 T6180 compound Active,Motif
R5323 T6180 T6177 appos Motif,p65
R5324 T6181 T6180 punct ",",Motif
R5325 T6182 T6180 conj Rixensart,Motif
R5326 T6183 T6182 punct ",",Rixensart
R5327 T6184 T6182 conj Belgium,Rixensart
R5328 T6185 T6174 punct ),kit
R5329 T6186 T6170 punct .,determined
R5330 T6187 T6196 prep In,incubated
R5331 T6188 T6187 pobj brief,In
R5332 T6189 T6196 punct ",",incubated
R5333 T6190 T6191 nummod 5,µg
R5334 T6191 T6196 nsubjpass µg,incubated
R5335 T6192 T6191 prep of,µg
R5336 T6193 T6194 amod nuclear,extracts
R5337 T6194 T6192 pobj extracts,of
R5338 T6195 T6196 auxpass were,incubated
R5339 T6196 T6196 ROOT incubated,incubated
R5340 T6197 T6196 prep with,incubated
R5341 T6198 T6199 det a,plate
R5755 T6647 T6646 punct (,optics
R5756 T6648 T6649 compound Leica,Microsystems
R5757 T6649 T6646 appos Microsystems,optics
R5758 T6650 T6649 punct ",",Microsystems
R5759 T6651 T6649 conj Wetzlar,Microsystems
R5760 T6652 T6651 punct ",",Wetzlar
R5761 T6653 T6651 conj Germany,Wetzlar
R5762 T6654 T6646 punct ),optics
R5763 T6655 T6629 punct .,characterised
R5764 T6656 T6657 aux To,determine
R5765 T6657 T6677 advcl determine,used
R5766 T6658 T6659 det the,specificity
R5767 T6659 T6657 dobj specificity,determine
R5768 T6660 T6659 prep of,specificity
R5769 T6661 T6662 det the,antibodies
R5770 T6662 T6660 pobj antibodies,of
R5771 T6663 T6662 punct ",",antibodies
R5772 T6664 T6665 compound rabbit,serum
R5773 T6665 T6666 compound serum,immunoglobulin
R5774 T6666 T6659 conj immunoglobulin,specificity
R5775 T6667 T6666 punct (,immunoglobulin
R5776 T6668 T6666 appos Dako,immunoglobulin
R5777 T6669 T6666 punct ),immunoglobulin
R5778 T6670 T6666 cc and,immunoglobulin
R5779 T6671 T6672 amod secondary,antibodies
R5780 T6672 T6666 conj antibodies,immunoglobulin
R5781 T6673 T6657 prep without,determine
R6102 T7081 T7082 punct -,EcoRI/3
R6103 T7082 T7083 compound EcoRI/3,′
R6104 T7083 T7077 pobj ′,into
R6105 T7084 T7085 nsubj blunt,ended
R6106 T7085 T7076 advcl ended,inserted
R6107 T7086 T7087 compound GFP,vector
R6108 T7087 T7085 dobj vector,ended
R6109 T7088 T7085 punct .,ended
R6110 T7089 T7090 amod Positive,clones
R6111 T7090 T7092 nsubjpass clones,confirmed
R6112 T7091 T7092 auxpass were,confirmed
R6113 T7092 T7092 ROOT confirmed,confirmed
R6114 T7093 T7092 agent by,confirmed
R6115 T7094 T7093 pobj digestion,by
R6116 T7095 T7094 cc and,digestion
R6117 T7096 T7094 conj size,digestion
R6118 T7097 T7094 conj analysis,digestion
R6119 T7098 T7092 prep by,confirmed
R6120 T7099 T7100 nummod 1,%
R6121 T7100 T7103 compound %,electrophoresis
R6122 T7101 T7102 amod agarose,gel
R6123 T7102 T7103 compound gel,electrophoresis
R6124 T7103 T7098 pobj electrophoresis,by
R6125 T7104 T7098 cc and,by
R6126 T7105 T7098 conj by,by
R6127 T7106 T7105 pcomp sequencing,by
R6128 T7107 T7092 punct .,confirmed
R6207 T7254 T7255 compound Transfection,HuT-78
R6208 T7255 T7256 compound HuT-78,cells
R6209 T7256 T7258 nsubjpass cells,transfected
R6210 T7257 T7258 auxpass were,transfected
R6211 T7258 T7258 ROOT transfected,transfected
R6212 T7259 T7258 prep with,transfected
R6213 T7260 T7261 det either,EP8
R6214 T7261 T7259 pobj EP8,with
R6215 T7262 T7261 cc or,EP8
R6216 T7263 T7264 compound GFP,vector
R6217 T7264 T7261 conj vector,EP8
R6218 T7265 T7266 advmod only,DNA
R6219 T7266 T7267 nsubj DNA,using
R6220 T7267 T7258 advcl using,transfected
R6221 T7268 T7269 compound solution,R
R6222 T7269 T7267 dobj R,using
R6223 T7270 T7269 punct ",",R
R6224 T7271 T7272 compound programme,V-001
R6225 T7272 T7269 appos V-001,R
R6226 T7273 T7267 prep at,using
R6227 T7274 T7275 det a,ratio
R6228 T7275 T7282 nmod ratio,DNA
R6229 T7276 T7275 prep of,ratio
R6230 T7277 T7280 nummod 3,cells/4
R6231 T7278 T7280 nummod ×,cells/4
R6232 T7279 T7280 nummod 106,cells/4
R6233 T7280 T7276 pobj cells/4,of
R6234 T7281 T7282 compound µg,DNA
R6235 T7282 T7273 pobj DNA,at
R6236 T7283 T7267 prep for,using
R6237 T7284 T7283 pobj 7,for
R6238 T7285 T7286 nummod 8,h
R6239 T7286 T7284 appos h,7
R6240 T7287 T7286 prep in,h
R6241 T7288 T7289 amod complete,medium
R6242 T7289 T7287 pobj medium,in
R6243 T7290 T7286 punct (,h
R6244 T7291 T7292 nummod 10,%
R6245 T7292 T7294 nmod %,serum
R6246 T7293 T7294 amod bovine,serum
R6259 T7306 T7305 prep for,protocol
R6260 T7307 T7306 pobj nucleofection,for
R6261 T7308 T7258 punct .,transfected
R6262 T7309 T7310 det The,medium
R6263 T7310 T7313 nsubjpass medium,changed
R6264 T7311 T7313 auxpass was,changed
R6265 T7312 T7313 advmod subsequently,changed
R6266 T7313 T7313 ROOT changed,changed
R6267 T7314 T7313 prep to,changed
R6268 T7315 T7317 nummod 1,RPMI
R6269 T7316 T7315 quantmod %,1
R6270 T7317 T7314 pobj RPMI,to
R6271 T7318 T7313 prep for,changed
R6272 T7319 T7320 nummod 24,h
R6273 T7320 T7318 pobj h,for
R6274 T7321 T7325 mark before,added
R6275 T7322 T7323 amod transfected,cells
R6276 T7323 T7325 nsubjpass cells,added
R6277 T7324 T7325 auxpass were,added
R6278 T7325 T7313 advcl added,changed
R6279 T7326 T7325 prep to,added
R6280 T7327 T7336 amod anti-CD3,performed
R6281 T7328 T7331 nummod /,wells
R6282 T7329 T7331 nummod CD28,wells
R6283 T7330 T7331 amod treated,wells
R6284 T7331 T7327 dobj wells,anti-CD3
R6285 T7332 T7327 cc and,anti-CD3
R6286 T7333 T7335 amod live,videomicroscopy
R6287 T7334 T7335 compound cell,videomicroscopy
R6288 T7335 T7327 conj videomicroscopy,anti-CD3
R6289 T7336 T7326 pobj performed,to
R6290 T7337 T7313 punct .,changed
R6411 T7473 T7476 compound Time-Lapse,cells
R6883 T7965 T7966 compound GraphPad,Prism
R6884 T7966 T7964 dobj Prism,using
R6885 T7967 T7966 nummod 4,Prism
R6886 T7968 T7970 punct (,Software
R6887 T7969 T7970 compound GraphPad,Software
R6888 T7970 T7966 conj Software,Prism
R6889 T7971 T7970 punct ",",Software
R6890 T7972 T7970 appos http://www.graphpad.com,Software
R6891 T7973 T7970 punct ),Software
R6892 T7974 T7944 punct .,presented
R6893 T7975 T7976 nsubj Results,were
R6894 T7976 T7976 ROOT were,were
R6895 T7977 T7976 acomp analysed,were
R6896 T7978 T7976 advcl using,were
R6897 T7979 T7980 amod one-way,ANOVA
R6898 T7980 T7978 dobj ANOVA,using
R6899 T7981 T7978 prep with,using
R6900 T7982 T7984 compound Newman-Keuls,test
R6901 T7983 T7984 compound post,test
R6902 T7984 T7981 pobj test,with
R6903 T7985 T7978 prep except,using
R6904 T7986 T7985 prep for,except
R6905 T7987 T7988 det the,data
R6906 T7988 T7986 pobj data,for
R6907 T7989 T7988 prep from,data
R6908 T7990 T7995 det the,study
R6909 T7991 T7993 prep in,inhaled
R6910 T7992 T7991 pobj vivo,in
R6911 T7993 T7995 amod inhaled,study
R6912 T7994 T7995 compound FP,study
R6913 T7995 T7989 pobj study,from
R6914 T7996 T7995 punct ",",study
R6915 T7997 T7999 nsubjpass which,analysed
R6916 T7998 T7999 auxpass was,analysed
R6917 T7999 T7995 relcl analysed,study
R6918 T8000 T7999 agent by,analysed
R6919 T8001 T8003 poss Friedman,test
R6920 T8002 T8001 case 's,Friedman
R6921 T8003 T8000 pobj test,by
R6922 T8004 T8003 prep with,test
R6923 T8005 T8006 amod subsequent,Wilcoxson
R6924 T8006 T8004 pobj Wilcoxson,with
R6925 T8007 T8008 amod matched,pair
R6926 T8008 T8009 nsubj pair,signed
R6927 T8009 T7976 conj signed,were
R6928 T8010 T8012 compound rank,test
R6929 T8011 T8012 compound sum,test
R6961 T8043 T8044 nummod 500,µg
R6962 T8044 T8040 conj µg,µg
R6963 T8045 T8044 prep of,µg
R6964 T8046 T8047 amod inhaled,FP
R6965 T8047 T8045 pobj FP,of
R6966 T8048 T8047 punct ",",FP
R6967 T8049 T8050 nsubj which,had
R6968 T8050 T8047 relcl had,FP
R6969 T8051 T8053 amod variable,levels
R6970 T8052 T8053 compound baseline,levels
R6971 T8053 T8050 dobj levels,had
R6972 T8054 T8029 punct .,used
R6973 T8055 T8058 nsubj We,assume
R6974 T8056 T8058 aux did,assume
R6975 T8057 T8058 neg not,assume
R6976 T8058 T8058 ROOT assume,assume
R6977 T8059 T8061 det a,distribution
R6978 T8060 T8061 amod Gaussian,distribution
R6979 T8061 T8058 dobj distribution,assume
R6980 T8062 T8061 prep of,distribution
R6981 T8063 T8064 det the,data
R6982 T8064 T8062 pobj data,of
R6983 T8065 T8061 amod due,distribution
R6984 T8066 T8065 pcomp to,due
R6985 T8067 T8069 det the,numbers
R7330 T8485 T8482 ccomp affect,investigated
R7331 T8486 T8487 compound anti-CD3,/
R7332 T8487 T8485 dobj /,affect
R7333 T8488 T8487 nummod CD28,/
R7334 T8489 T8482 dep stimulated,investigated
R7335 T8490 T8491 amod nuclear,import
R7336 T8491 T8489 dobj import,stimulated
R7337 T8492 T8491 prep of,import
R7338 T8493 T8492 pobj GATA-3,of
R7339 T8494 T8482 punct .,investigated
R7340 T8495 T8502 nsubj Stimulation,resulted
R7341 T8496 T8495 prep of,Stimulation
R7342 T8497 T8496 pobj cells,of
R7343 T8498 T8497 prep with,cells
R7344 T8499 T8500 compound anti-CD3,/
R7345 T8500 T8498 pobj /,with
R7346 T8501 T8500 nummod CD28,/
R7482 T8637 T8636 prep of,loss
R7483 T8638 T8639 amod GATA-3,binding
R7484 T8639 T8636 amod binding,loss
R7485 T8640 T8639 prep to,binding
R7486 T8641 T8644 det the,promoter
R7488 T8643 T8644 compound IL-5,promoter
R7489 T8644 T8640 pobj promoter,to
R7490 T8645 T8646 punct (,Figure
R7491 T8646 T8644 appos Figure,promoter
R7492 T8647 T8646 nummod 1E,Figure
R7493 T8648 T8646 punct ),Figure
R7494 T8649 T8587 punct .,was
R7848 T9109 T9110 compound Ligand-Activated,GR
R8972 T10422 T10417 acl utilizing,assay
R8973 T10423 T10425 amod purified,GATA-3
R8974 T10424 T10425 amod activated,GATA-3
R8975 T10425 T10422 dobj GATA-3,utilizing
R8976 T10426 T10425 punct ",",GATA-3
R8977 T10427 T10425 conj importin-α,GATA-3
R8978 T10428 T10412 punct ",",Using
R8979 T10429 T10412 cc and,Using
R8980 T10430 T10434 advcl activated,demonstrated
R8981 T10431 T10430 dobj GR,activated
R8982 T10432 T10434 punct ",",demonstrated
R8983 T10433 T10434 nsubj we,demonstrated
R8984 T10434 T10434 ROOT demonstrated,demonstrated
R8985 T10435 T10436 mark that,activated
R8986 T10436 T10434 ccomp activated,demonstrated
R8987 T10437 T10439 nsubj GR,increased
R8988 T10438 T10439 advmod significantly,increased
R9208 T10658 T10660 nummod p65,translocation
R9209 T10659 T10660 amod nuclear,translocation
R9210 T10660 T10657 pobj translocation,on
R9211 T10661 T10654 conj measured,had
R9212 T10662 T10661 prep at,measured
R9213 T10663 T10664 nummod 60,min
R9214 T10664 T10662 pobj min,at
R9215 T10665 T10666 punct (,Figure
R9216 T10666 T10664 appos Figure,min
R9217 T10667 T10666 nummod 5D,Figure
R9218 T10668 T10666 punct ),Figure
R9219 T10669 T10642 punct .,was
R10235 T11922 T11924 det The,Effect
R10236 T11923 T11924 compound Inhibitory,Effect
R10237 T11924 T11945 nsubj Effect,demonstrated
R10238 T11925 T11924 prep of,Effect
R10239 T11926 T11925 pobj Corticosteroids,of
R10240 T11927 T11924 prep on,Effect
R10241 T11928 T11930 compound GATA-3,Localization
R10242 T11929 T11930 compound Nuclear,Localization
R10243 T11930 T11927 pobj Localization,on
R10244 T11931 T11930 prep in,Localization
R10245 T11932 T11933 compound Primary,T
R10246 T11933 T11934 compound T,Lymphocytes
R10247 T11934 T11936 compound Lymphocytes,Vivo
R10248 T11935 T11936 compound Ex,Vivo
R10249 T11936 T11931 pobj Vivo,in
R10250 T11937 T11924 cc and,Effect
R10251 T11938 T11945 prep In,demonstrated
R10252 T11939 T11940 compound Vivo,Treatment
R10253 T11940 T11938 pobj Treatment,In
R10254 T11941 T11940 prep with,Treatment
R10255 T11942 T11944 compound FP,vivo
R10335 T12022 T12023 nsubj FP,suppresses
R10336 T12023 T12016 ccomp suppresses,indicated
R10337 T12024 T12023 dobj IL-4,suppresses
R10338 T12025 T12024 cc and,IL-4
R10339 T12026 T12028 nummod -5,expression
R10340 T12027 T12028 compound gene,expression
R10341 T12028 T12024 conj expression,IL-4
R10342 T12029 T12028 cc and,expression
R10343 T12030 T12016 conj attenuated,indicated
R10344 T12031 T12032 det the,interaction
R10345 T12032 T12030 dobj interaction,attenuated
R10346 T12033 T12032 prep of,interaction
R10347 T12034 T12033 pobj GATA-3,of
R10348 T12035 T12032 prep with,interaction
R10349 T12036 T12035 pobj importin-α,with
R10450 T12137 T12140 nsubj this,reach
R10451 T12138 T12140 aux did,reach
R10452 T12139 T12140 neg not,reach
R10453 T12140 T12140 ROOT reach,reach
R10454 T12141 T12140 dobj significance,reach
R10455 T12142 T12140 advcl using,reach
R10456 T12143 T12146 poss Wilcoxon,analysis
R10457 T12144 T12143 case 's,Wilcoxon
R10458 T12145 T12146 amod post-test,analysis
R10459 T12146 T12142 dobj analysis,using
R10460 T12147 T12153 punct (,due
R10461 T12148 T12153 nsubj W,due
R10462 T12149 T12150 punct =,6.00
R10463 T12150 T12148 nummod 6.00,W
R10464 T12151 T12148 punct ),W
R10465 T12152 T12153 advmod probably,due
R10466 T12153 T12140 advcl due,reach
R10467 T12154 T12153 pcomp to,due
R10468 T12155 T12156 amod low,numbers
R10469 T12156 T12154 pobj numbers,to
R10470 T12157 T12156 prep of,numbers
R10471 T12158 T12157 pobj participants,of
R10472 T12159 T12140 punct .,reach
R10473 T12160 T12161 amod Similar,results
R10474 T12161 T12163 nsubjpass results,observed
R10505 T12192 T12197 nsubj interaction,result
R10506 T12193 T12192 prep of,interaction
R10507 T12194 T12193 pobj GATA-3,of
R10508 T12195 T12197 aux did,result
R10509 T12196 T12197 neg not,result
R10510 T12197 T12197 ROOT result,result
R10511 T12198 T12197 prep from,result
R10512 T12199 T12201 det the,recycling
R10513 T12200 T12201 amod defective,recycling
R10514 T12201 T12198 pobj recycling,from
R10515 T12202 T12201 prep of,recycling
R10516 T12203 T12202 pobj importin-α,of
R10517 T12204 T12197 punct ",",result
R10518 T12205 T12197 prep as,result
R10519 T12206 T12208 det a,decrease
R10520 T12207 T12208 amod significant,decrease
R10521 T12208 T12205 pobj decrease,as
R10522 T12209 T12208 prep in,decrease
R10523 T12210 T12211 det the,abundance
R10524 T12211 T12209 pobj abundance,in
R10525 T12212 T12211 prep of,abundance
R10526 T12213 T12212 pobj importin-α,of
R10527 T12214 T12208 prep in,decrease
R10528 T12215 T12217 det the,pool
R10529 T12216 T12217 amod cytoplasmic,pool
R10530 T12217 T12214 pobj pool,in
R10531 T12218 T12220 auxpass was,detected
R10532 T12219 T12220 neg not,detected
R10533 T12220 T12197 conj detected,result
R10534 T12221 T12222 punct (,Figure
R10535 T12222 T12220 advmod Figure,detected
R10536 T12223 T12222 nummod 6E,Figure
R10537 T12224 T12222 punct ),Figure
R10538 T12225 T12197 punct .,result
R10539 T12226 T12228 nsubj We,examined
R10540 T12227 T12228 advmod further,examined
R10541 T12228 T12228 ROOT examined,examined
R10542 T12229 T12233 mark whether,affect
R10543 T12230 T12231 amod inhaled,FP
R10544 T12231 T12233 nsubj FP,affect
R10545 T12232 T12233 aux could,affect
R10546 T12233 T12228 ccomp affect,examined
R10547 T12234 T12235 amod cellular,localization
R10548 T12235 T12233 dobj localization,affect
R10549 T12236 T12235 prep of,localization
R10550 T12237 T12236 pobj GATA-3,of
R10551 T12238 T12235 prep in,localization
R10552 T12239 T12242 amod peripheral,cells
R10553 T12240 T12242 compound blood,cells
R10584 T12271 T12276 amod GATA-3,cells
R10661 T12348 T12349 nummod 500,µg
R10662 T12349 T12346 appos µg,FP
R10663 T12350 T12346 punct ),FP
R10664 T12351 T12345 conj induced,inhaled
R10665 T12352 T12353 amod significant,loss
R10776 T12463 T12464 compound T,cells
R10777 T12464 T12461 pobj cells,in
R10778 T12465 T12457 prep in,inhibited
R10779 T12466 T12465 pobj vivo,in
R10780 T12467 T12457 prep at,inhibited
R10781 T12468 T12469 nummod 2,h
R10782 T12469 T12467 pobj h,at
R10783 T12470 T12469 prep in,h
R10784 T12471 T12470 pobj samples,in
R10785 T12472 T12471 prep from,samples
R10786 T12473 T12474 nummod two,patients
R10787 T12474 T12472 pobj patients,from
R10788 T12475 T12474 punct (,patients
R10789 T12476 T12474 appos Figure,patients
R10790 T12477 T12476 nummod 7E,Figure
R10791 T12478 T12474 punct ),patients
R10792 T12479 T12457 punct .,inhibited
R10793 T12480 T12485 advcl Taken,suggest
R10794 T12481 T12480 advmod together,Taken
R10795 T12482 T12485 punct ",",suggest
R10796 T12483 T12484 poss our,data
R10797 T12484 T12485 nsubj data,suggest
R10798 T12485 T12485 ROOT suggest,suggest
R10799 T12486 T12487 mark that,inhaled
R10800 T12487 T12485 ccomp inhaled,suggest
R10801 T12488 T12489 nsubj FP,reduces
R10802 T12489 T12487 pcomp reduces,inhaled
R10803 T12490 T12491 amod nuclear,localization
R10804 T12491 T12489 dobj localization,reduces
R10805 T12492 T12491 prep of,localization
R10806 T12493 T12492 pobj GATA-3,of
R10807 T12494 T12491 prep in,localization
R10808 T12495 T12494 pobj vivo,in
R10809 T12496 T12489 prep by,reduces
R10810 T12497 T12498 advmod acutely,inhibiting
R10811 T12498 T12496 pcomp inhibiting,by
R12351 T14339 T14337 conj interacting,distinct
R12352 T14340 T14341 amod molecular,mechanisms
R12353 T14341 T14335 pobj mechanisms,via
R12354 T14342 T14312 punct .,demonstrated
R12355 T14343 T14347 advmod Firstly,appears
R12356 T14344 T14347 punct ",",appears
R12357 T14345 T14346 compound corticosteroid-activated,GR
R12358 T14346 T14347 nsubj GR,appears
R12359 T14347 T14347 ROOT appears,appears
R12360 T14348 T14349 aux to,compete
R12361 T14349 T14347 xcomp compete,appears
R12362 T14350 T14349 prep with,compete
R12363 T14351 T14352 amod activated,GATA-3
R12364 T14352 T14350 pobj GATA-3,with
R12365 T14353 T14349 prep for,compete
R12366 T14354 T14355 amod nuclear,import
R12367 T14355 T14353 pobj import,for
R12368 T14356 T14349 prep via,compete
R12369 T14357 T14356 pobj importin-α,via
R12370 T14358 T14357 punct ",",importin-α
R12371 T14359 T14361 nsubjpass which,required
R12372 T14360 T14361 auxpass is,required
R12373 T14361 T14349 advcl required,compete
R12374 T14362 T14361 prep for,required
R12375 T14363 T14365 det the,transport
R12376 T14364 T14365 amod nuclear,transport
R12377 T14365 T14362 pobj transport,for
R12378 T14366 T14365 prep of,transport
R12379 T14367 T14368 preconj both,GATA-3
R12380 T14368 T14366 pobj GATA-3,of
R12381 T14369 T14368 cc and,GATA-3
R12382 T14370 T14368 conj GR,GATA-3
R12383 T14371 T14347 punct .,appears
R12384 T14372 T14378 advmod Secondly,increase
R12385 T14373 T14378 punct ",",increase
R12386 T14374 T14378 nsubj corticosteroids,increase
R12387 T14375 T14374 prep at,corticosteroids
R12388 T14376 T14377 amod higher,concentrations
R12389 T14377 T14375 pobj concentrations,at
R12430 T14418 T14378 punct .,increase
R12431 T14419 T14422 nsubj We,shown
R12432 T14420 T14422 aux have,shown
R12433 T14421 T14422 advmod previously,shown
R12434 T14422 T14422 ROOT shown,shown
R12435 T14423 T14433 mark that,involves
R12436 T14424 T14433 nsubj translocation,involves
R12437 T14425 T14424 prep of,translocation
R12438 T14426 T14425 pobj GATA-3,of
R12439 T14427 T14424 prep from,translocation
R12440 T14428 T14429 det the,cytoplasm
R12441 T14429 T14427 pobj cytoplasm,from
R12442 T14430 T14424 prep to,translocation
R12443 T14431 T14432 det the,nucleus
R12444 T14432 T14430 pobj nucleus,to
R12445 T14433 T14422 ccomp involves,shown
R12446 T14434 T14437 det the,protein
R12447 T14435 T14436 amod nuclear,transporter
R12448 T14436 T14437 compound transporter,protein
R12449 T14437 T14438 compound protein,importin-α
R12450 T14438 T14433 dobj importin-α,involves
R12451 T14439 T14438 punct ",",importin-α
R12452 T14440 T14441 nsubj which,interacts
R12453 T14441 T14438 relcl interacts,importin-α
R12454 T14442 T14441 prep with,interacts
R12455 T14443 T14445 amod phosphorylated,[
R12456 T14444 T14445 compound GATA-3,[
R12457 T14445 T14442 pobj [,with
R12708 T14696 T14694 pobj synthesis,in
R12709 T14697 T14698 auxpass are,required
R12710 T14698 T14687 advcl required,be
R12711 T14699 T14677 punct .,is
R12712 T14700 T14702 det This,mechanism
R12713 T14701 T14702 amod acute,mechanism
R12714 T14702 T14705 nsubj mechanism,contribute
R12715 T14703 T14705 aux may,contribute
R12716 T14704 T14705 advmod also,contribute
R12717 T14705 T14705 ROOT contribute,contribute
R12718 T14706 T14705 prep to,contribute
R12719 T14707 T14708 det the,reduction
R12720 T14708 T14706 pobj reduction,to
R12721 T14709 T14708 prep in,reduction
R12722 T14710 T14712 amod GATA-3,import
R12723 T14711 T14712 amod nuclear,import
R12724 T14712 T14709 pobj import,in
R12725 T14713 T14705 cc and,contribute
R12726 T14714 T14715 aux may,play
R12727 T14715 T14705 conj play,contribute
R12728 T14716 T14718 det a,role
R12729 T14717 T14718 amod major,role
R12730 T14718 T14715 dobj role,play
R12731 T14719 T14715 prep at,play
R12732 T14720 T14722 amod low,concentrations
R12733 T14721 T14722 amod corticosteroid,concentrations
R12734 T14722 T14719 pobj concentrations,at
R12735 T14723 T14719 cc and/or,at
R12736 T14724 T14719 conj at,at
R12737 T14725 T14726 amod early,time
R12738 T14726 T14724 pobj time,at
R12739 T14727 T14728 compound points,prior
R12740 T14728 T14715 advmod prior,play
R14195 T16509 T16508 prep as,presented
R14693 T17131 T17128 pobj 8,at
R14694 T17132 T17133 compound M,FP
R14695 T17133 T17123 dobj FP,demonstrates
R14696 T17134 T17123 punct ),demonstrates
R14697 T17135 T17123 cc and,demonstrates
R14698 T17136 T17123 conj concentration,demonstrates
R14699 T17137 T17136 punct -,concentration
R14700 T17138 T17141 punct (,min
R14701 T17139 T17141 prep at,min
R14702 T17140 T17141 nummod 60,min
R14703 T17141 T17136 appos min,concentration
R14704 T17142 T17141 prep after,min
R14705 T17143 T17142 pobj stimulation,after
R14706 T17144 T17141 punct ),min
R14707 T17145 T17146 amod dependent,induction
R14708 T17146 T17136 conj induction,concentration
R14709 T17147 T17146 prep of,induction
R14710 T17148 T17150 amod FP-activated,interaction
R14711 T17149 T17150 compound GR,interaction
R14712 T17150 T17147 pobj interaction,of
R14713 T17151 T17150 prep with,interaction
R14714 T17152 T17151 pobj importin-α,with
R14715 T17153 T17154 punct (,Imp-α
R14716 T17154 T17152 appos Imp-α,importin-α
R14717 T17155 T17154 punct ),Imp-α
R14746 T17184 T17185 advmod at,least
R14747 T17185 T17186 advmod least,three
R14748 T17186 T17188 nummod three,experiments
R14749 T17187 T17188 amod independent,experiments
R14750 T17188 T17183 pobj experiments,of
R14751 T17189 T17179 punct .,represents
R14752 T17190 T17192 nmod ***,<
R14753 T17191 T17192 nmod p,<
R14754 T17192 T17193 nmod <,0.001
R14755 T17193 T17194 nsubj 0.001,compared
R14756 T17194 T17194 ROOT compared,compared
R14757 T17195 T17196 aux to,control
R14758 T17196 T17194 xcomp control,compared
R14759 T17197 T17200 punct ",",<
R14760 T17198 T17200 dep ###,<
R14761 T17199 T17200 dep p,<
R14762 T17200 T17201 nmod <,0.001
R14763 T17201 T17194 dobj 0.001,compared
R14764 T17202 T17194 punct .,compared
R14765 T17203 T17209 punct (,demonstrated
R14766 T17204 T17208 nmod B,analysis
R14767 T17205 T17204 punct ),B
R14768 T17206 T17208 compound Western,analysis
R14769 T17207 T17208 compound blot,analysis
R14770 T17208 T17209 nsubj analysis,demonstrated
R14771 T17209 T17209 ROOT demonstrated,demonstrated
R14772 T17210 T17232 det a,induction
R14773 T17211 T17232 npadvmod time,induction
R14774 T17212 T17232 punct -,induction
R14775 T17213 T17232 punct (,induction
R14776 T17214 T17232 nmod at,induction
R14777 T17215 T17219 nummod 10,FP
R14778 T17216 T17217 quantmod −,8
R14779 T17217 T17219 nummod 8,FP
R14780 T17218 T17219 compound M,FP
R14781 T17219 T17214 pobj FP,at
R14782 T17220 T17214 punct ),at
R14783 T17221 T17214 cc and,at
R14784 T17222 T17214 conj concentration,at
R14785 T17223 T17222 punct -,concentration
R14786 T17224 T17222 punct (,concentration
R14787 T17225 T17222 prep at,concentration
R14788 T17226 T17227 nummod 60,min
R14789 T17227 T17225 pobj min,at
R14790 T17228 T17227 prep after,min
R14791 T17229 T17228 pobj stimulation,after
R14792 T17230 T17222 punct ),concentration
R14793 T17231 T17232 amod dependent,induction
R14794 T17232 T17209 dobj induction,demonstrated
R14795 T17233 T17232 prep of,induction
R14824 T17262 T17257 pobj experiments,of
R14825 T17263 T17253 punct .,represents
R14826 T17264 T17266 compound ***,<
R14827 T17265 T17266 compound p,<
R14828 T17266 T17268 nsubj <,compared
R14829 T17267 T17266 nummod 0.001,<
R14830 T17268 T17268 ROOT compared,compared
R14831 T17269 T17270 aux to,control
R14832 T17270 T17268 xcomp control,compared
R14833 T17271 T17268 punct .,compared
R14834 T17272 T17273 punct (,C
R14835 T17273 T17277 nmod C,analysis
R14836 T17274 T17273 punct ),C
R14837 T17275 T17277 amod Western,analysis
R14838 T17276 T17277 compound blot,analysis
R14839 T17277 T17289 nsubj analysis,demonstrated
R14840 T17278 T17277 prep of,analysis
R14841 T17279 T17280 amod HuT-78,cells
R14842 T17280 T17278 pobj cells,of
R14843 T17281 T17280 acl treated,cells
R14844 T17282 T17281 prep with,treated
R14845 T17283 T17282 pobj FP,with
R14846 T17284 T17283 cc and,FP
R14847 T17285 T17286 compound anti-CD3,/
R14848 T17286 T17283 conj /,FP
R15497 T18049 T18048 pobj means,as
R15498 T18050 T18051 compound ±,SEM
R15499 T18051 T18054 dep SEM,p
R15500 T18052 T18051 punct ",",SEM
R15501 T18053 T18051 punct *,SEM
R15502 T18054 T18036 dep p,are
R15503 T18055 T18056 nmod <,0.05
R15504 T18056 T18054 npadvmod 0.05,p
R15505 T18057 T18036 punct .,are
R15506 T18058 T18062 punct (,induces
R15507 T18059 T18061 nmod E,FP
R15508 T18060 T18061 punct ),FP
R15509 T18061 T18062 nsubj FP,induces
R15510 T18062 T18062 ROOT induces,induces
R15511 T18063 T18064 compound MKP-1,mRNA
R15512 T18064 T18062 dobj mRNA,induces
R15513 T18065 T18062 prep in,induces
R15514 T18066 T18068 det a,manner
R15515 T18067 T18068 amod time-dependent,manner
R15516 T18068 T18065 pobj manner,in
R15517 T18069 T18062 punct .,induces
R15518 T18070 T18071 nsubj Results,are
R15519 T18071 T18071 ROOT are,are
R15520 T18072 T18071 attr representative,are
R15778 T18446 T18444 pobj importin-α,with
R15831 T18499 T18497 punct .,was
R15832 T18500 T18503 punct *,0.05
R15833 T18501 T18502 compound p,<
R15834 T18502 T18503 compound <,0.05
R15835 T18503 T18503 ROOT 0.05,0.05
R15836 T18504 T18508 punct ",",0.01
R15837 T18505 T18508 amod **,0.01
R15838 T18506 T18508 compound p,0.01
R15839 T18507 T18508 compound <,0.01
R15840 T18508 T18503 appos 0.01,0.05
R15841 T18509 T18508 prep between,0.01
R15842 T18510 T18509 pobj groups,between
R15843 T18511 T18503 punct .,0.05
R15844 T18512 T18513 det All,results
R15845 T18513 T18515 nsubjpass results,expressed
R15846 T18514 T18515 auxpass are,expressed
R15847 T18515 T18515 ROOT expressed,expressed
R15848 T18516 T18515 prep as,expressed
R15849 T18517 T18519 amod mean,SEM
R15850 T18518 T18519 compound ±,SEM
R15851 T18519 T18516 pobj SEM,as
R15852 T18520 T18519 prep of,SEM
R15853 T18521 T18523 nummod three,experiments
R15854 T18522 T18523 amod independent,experiments
R15855 T18523 T18520 pobj experiments,of
R16205 T18975 T18975 ROOT stimulated,stimulated
R15856 T18524 T18523 cc and,experiments
R15857 T18525 T18515 advcl analysed,expressed
R15858 T18526 T18525 agent by,analysed
R15859 T18527 T18526 pobj ANOVA,by
R15860 T18528 T18525 acl followed,analysed
R15861 T18529 T18528 agent by,followed
R15862 T18530 T18529 pobj Newman-Keuls,by
R15863 T18531 T18515 conj post-test,expressed
R15864 T18532 T18515 punct .,expressed
R16160 T18930 T18931 compound Fluticasone,propionate
R16161 T18931 T18934 nsubj propionate,affect
R16162 T18932 T18934 aux does,affect
R16163 T18933 T18934 neg not,affect
R16164 T18934 T18934 ROOT affect,affect
R16165 T18935 T18937 amod GATA-3,export
R16166 T18936 T18937 amod nuclear,export
R16167 T18937 T18934 dobj export,affect
R16168 T18938 T18934 punct .,affect
R16169 T18939 T18940 punct (,A
R16170 T18940 T18944 nmod A,analysis
R16171 T18941 T18940 punct ),A
R16172 T18942 T18944 amod Western,analysis
R16173 T18943 T18944 compound blot,analysis
R16174 T18944 T18975 nsubj analysis,stimulated
R16229 T18999 T19002 dep anti-CD3,stimulated
R16230 T19000 T18999 dobj /,anti-CD3
R16231 T19001 T19000 nummod CD28,/
R16232 T19002 T18998 pcomp stimulated,to
R16233 T19003 T19002 dobj cells,stimulated
R16234 T19004 T19002 punct .,stimulated
R16235 T19005 T19010 punct (,analysis
R16236 T19006 T19010 nmod B,analysis
R16237 T19007 T19010 punct ),analysis
R16238 T19008 T19010 amod Western,analysis
R16239 T19009 T19010 compound blot,analysis
R16240 T19010 T19010 ROOT analysis,analysis
R16241 T19011 T19010 acl showing,analysis
R16242 T19012 T19022 mark that,affect
R16243 T19013 T19022 nsubj FP,affect
R16244 T19014 T19016 punct (,−
R16245 T19015 T19016 nummod 10,−
R16246 T19016 T19022 nsubj −,affect
R16247 T19017 T19016 nummod 8,−
R16248 T19018 T19016 appos M,−
R16249 T19019 T19016 punct ),−
R16250 T19020 T19022 aux does,affect
R16251 T19021 T19022 neg not,affect
R17101 T20008 T20004 punct ),FP
R17102 T20009 T20001 prep on,effect
R17103 T20010 T20014 nmod GR,localisation
R17104 T20011 T20010 cc and,GR
R17105 T20012 T20010 conj GATA-3,GR
R17106 T20013 T20014 amod nuclear,localisation
R17107 T20014 T20009 pobj localisation,on
R17108 T20015 T19997 punct .,immunocytochemistry
R17109 T20016 T20021 punct (,immunoreactivity
R17110 T20017 T20021 nmod B,immunoreactivity
R17111 T20018 T20017 punct ),B
R17112 T20019 T20020 compound Nuclear,GATA-3
R17113 T20020 T20021 compound GATA-3,immunoreactivity
R17114 T20021 T20021 ROOT immunoreactivity,immunoreactivity
R17115 T20022 T20021 prep in,immunoreactivity
R17116 T20023 T20022 pobj PBMCs,in
R17117 T20024 T20021 prep from,immunoreactivity
R17118 T20025 T20028 nummod seven,patients
R17119 T20026 T20028 amod steroid-naïve,patients
R17120 T20027 T20028 compound asthma,patients
R17121 T20028 T20024 pobj patients,from
R17157 T20064 T20066 punct *,<
R17158 T20065 T20066 compound p,<
R17159 T20066 T20053 conj <,presented
R17160 T20067 T20071 nummod 0.05,test
R17161 T20068 T20071 poss Wilcoxon,test
R17162 T20069 T20068 case 's,Wilcoxon
R17163 T20070 T20071 compound rank,test
R17164 T20071 T20066 appos test,<
R17165 T20072 T20071 prep compared,test
R17166 T20073 T20072 prep with,compared
R17167 T20074 T20073 pobj placebo,with
R17168 T20075 T20053 punct .,presented
R17169 T20076 T20080 punct (,analyses
R17170 T20077 T20080 compound C,analyses
R17171 T20078 T20079 punct ),Immunoblotting
R17172 T20079 T20080 compound Immunoblotting,analyses
R17173 T20080 T20083 nsubj analyses,demonstrated
R17174 T20081 T20080 prep of,analyses
R17175 T20082 T20081 pobj PBMCs,of
R17176 T20083 T20083 ROOT demonstrated,demonstrated
R17177 T20084 T20086 det a,decrease
R17178 T20085 T20086 amod time-dependent,decrease
R17179 T20086 T20083 dobj decrease,demonstrated
R17180 T20087 T20086 prep in,decrease
R17181 T20088 T20089 amod nuclear,expression
R17182 T20089 T20087 pobj expression,in
R17183 T20090 T20089 prep of,expression
R17184 T20091 T20090 pobj GATA-3,of
R17185 T20092 T20083 punct ",",demonstrated
R17186 T20093 T20083 cc and,demonstrated
R17187 T20094 T20097 amod increased,expression
R17188 T20095 T20097 amod cytoplasmic,expression
R17189 T20096 T20097 amod GATA-3,expression
R17190 T20097 T20083 conj expression,demonstrated
R17191 T20098 T20097 prep after,expression
R17192 T20099 T20098 pobj inhalation,after
R17193 T20100 T20099 prep of,inhalation
R17194 T20101 T20100 pobj FP,of
R17195 T20102 T20083 punct .,demonstrated
R17196 T20103 T20110 punct (,demonstrated
R17197 T20104 T20107 compound D,analyses
R17198 T20105 T20106 punct ),Immunoblotting
R17199 T20106 T20107 compound Immunoblotting,analyses
R17237 T20144 T20147 amod nuclear,fractions
R17238 T20145 T20144 cc and,nuclear
R17239 T20146 T20144 conj cytoplasmic,nuclear
R17240 T20147 T20142 pobj fractions,for
R17241 T20148 T20137 advmod respectively,confirmed
R17242 T20149 T20137 punct .,confirmed
R17243 T20150 T20164 nsubjpass Quantification,shown
R17244 T20151 T20150 prep of,Quantification
R17245 T20152 T20154 det the,data
R17246 T20153 T20154 compound densitometry,data
R17247 T20154 T20151 pobj data,of
R17248 T20155 T20154 prep in,data
R17249 T20156 T20157 punct (,C
R17250 T20157 T20155 pobj C,in
R17251 T20158 T20150 punct ),Quantification
R17252 T20159 T20150 cc and,Quantification
R17253 T20160 T20161 punct (,D
R17254 T20161 T20150 conj D,Quantification
R17255 T20162 T20161 punct ),D
R17256 T20163 T20164 auxpass is,shown
R17257 T20164 T20164 ROOT shown,shown
R17258 T20165 T20164 prep as,shown
R17259 T20166 T20168 det a,plot
R17260 T20167 T20168 compound box-and-whiskers,plot
R17261 T20168 T20165 pobj plot,as
R17262 T20169 T20168 prep of,plot
R17263 T20170 T20169 pobj results,of
R17264 T20171 T20170 prep from,results
R17265 T20172 T20175 amod n,participants
R17266 T20173 T20174 punct =,6
R17267 T20174 T20175 nummod 6,participants
R17268 T20175 T20171 pobj participants,from
R17269 T20176 T20179 prep for,were
R17270 T20177 T20176 pobj which,for
R17271 T20178 T20179 nsubj data,were
R17272 T20179 T20175 relcl were,participants
R17273 T20180 T20179 acomp available,were
R17274 T20181 T20164 punct .,shown
R17275 T20182 T20186 advmod *,compared
R17276 T20183 T20184 compound p,<
R17277 T20184 T20185 compound <,0.05
R17278 T20185 T20186 advmod 0.05,compared
R17315 T20222 T20223 det The,results
R17316 T20223 T20229 nsubj results,are
R17317 T20224 T20223 acl shown,results
R17318 T20225 T20224 prep in,shown
R17319 T20226 T20227 punct (,E
R17320 T20227 T20225 pobj E,in

UBERON-AE

Id Subject Object Predicate Lexical cue
T87 987-992 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T88 1752-1757 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1179 12078-12083 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T1180 12267-12272 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T6271 19564-19569 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T7168 20915-20920 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T11222 36900-36905 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T11223 37102-37107 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T13159 44390-44395 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood

GO-BP

Id Subject Object Predicate Lexical cue
T757 720-732 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T758 857-867 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T759 1288-1323 http://purl.obolibrary.org/obo/GO_0002147 denotes glucocorticoid receptor for nuclear
T760 1316-1333 http://purl.obolibrary.org/obo/GO_0051169 denotes nuclear transport
T761 1324-1333 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T762 1434-1458 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T763 1434-1458 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T764 1434-1458 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T765 1434-1458 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T766 1460-1464 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T767 1517-1520 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T768 1466-1477 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T3229 7614-7627 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3230 10008-10021 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3231 11883-11896 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3232 7720-7740 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T3233 7814-7835 http://purl.obolibrary.org/obo/GO_0006338 denotes chromatin remodelling
T3234 8482-8497 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T3235 8836-8850 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3236 8906-8920 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3237 11048-11062 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T3238 8851-8857 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T3239 10290-10297 http://purl.obolibrary.org/obo/GO_0023052 denotes signals
T3240 8870-8881 http://purl.obolibrary.org/obo/GO_0006810 denotes transported
T3241 9393-9402 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T3242 8870-8898 http://purl.obolibrary.org/obo/GO_0051169 denotes transported into the nucleus
T3243 9393-9419 http://purl.obolibrary.org/obo/GO_0051169 denotes transport into the nucleus
T3244 8891-8928 http://purl.obolibrary.org/obo/GO_0006606 denotes nucleus by the nuclear import protein
T3245 8914-8928 http://purl.obolibrary.org/obo/GO_0017038 denotes import protein
T3246 9029-9041 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3247 9111-9123 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3248 10163-10175 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3249 10228-10240 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T3250 12240-12252 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T3251 9198-9213 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3252 11981-11996 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3253 9243-9246 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T3254 9281-9285 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T3255 9255-9279 http://purl.obolibrary.org/obo/GO_0034199 denotes activated protein kinase
T3256 9255-9279 http://purl.obolibrary.org/obo/GO_0032147 denotes activated protein kinase
T3257 9255-9279 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T3258 9255-9279 http://purl.obolibrary.org/obo/GO_0032111 denotes activated protein kinase
T3259 9758-9781 http://purl.obolibrary.org/obo/GO_0051384 denotes glucocorticoid response
T3260 10180-10189 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T3261 10280-10289 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T3262 10322-10336 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T3263 11016-11026 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3264 11818-11828 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T3265 11108-11121 http://purl.obolibrary.org/obo/GO_0003755 denotes immunophilins
T3266 11181-11187 http://purl.obolibrary.org/obo/GO_0003777 denotes dynein
T3267 11525-11528 http://purl.obolibrary.org/obo/GO_0004096 denotes CAT
T3268 12096-12111 http://purl.obolibrary.org/obo/GO_0001775 denotes cells activated
T4298 13496-13499 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T4299 13826-13838 http://purl.obolibrary.org/obo/GO_0009293 denotes Transduction
T4599 14488-14500 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T4829 14566-14587 http://purl.obolibrary.org/obo/GO_0001171 denotes Reverse Transcription
T4830 14574-14587 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T4831 14622-14627 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T4832 14854-14856 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T4833 14914-14916 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T5179 15314-15319 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T5180 15541-15549 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T6713 19324-19330 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T7113 19992-20001 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T7114 20641-20650 http://purl.obolibrary.org/obo/GO_0007586 denotes digestion
T7596 21257-21263 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T8657 23314-23329 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T8658 23439-23453 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T8659 23851-23860 http://purl.obolibrary.org/obo/GO_0051235 denotes retention
T9278 26000-26014 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T9279 26568-26582 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T10687 28290-28293 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10688 28294-28298 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10689 28405-28409 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10690 28571-28575 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10691 28386-28397 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10692 28410-28421 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10693 28501-28516 http://purl.obolibrary.org/obo/GO_0001775 denotes cells activated
T10694 28576-28591 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10695 28629-28644 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10696 28819-28834 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10697 28961-28976 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T10698 29225-29239 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T10699 31393-31407 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T10700 33089-33103 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T10701 30947-30953 http://purl.obolibrary.org/obo/GO_0085030 denotes mutual
T10702 32583-32597 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10703 32647-32661 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10704 33037-33051 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T10705 32605-32616 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T10706 32720-32732 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12574 35776-35791 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T12575 39891-39906 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T12576 36854-36862 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T12577 36863-36875 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12578 39483-39495 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12579 37831-37834 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T12580 37835-37839 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12581 39693-39697 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12582 37840-37855 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12583 39714-39729 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12584 39854-39868 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15238 40051-40064 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15239 41018-41031 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15240 41484-41497 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15241 43698-43711 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T15242 40215-40229 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15243 40615-40629 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15244 41114-41128 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15245 41253-41267 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15246 42406-42420 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15247 42864-42878 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15248 43317-43331 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15249 44671-44685 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T15250 40272-40289 http://purl.obolibrary.org/obo/GO_0051169 denotes nuclear transport
T15251 40280-40289 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T15252 40420-40423 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15253 40500-40503 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15254 42567-42570 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15255 42894-42897 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15256 43065-43068 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15257 43221-43224 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15258 40424-40428 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15259 40504-40508 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15260 42571-42575 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15261 42650-42654 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15262 42898-42902 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15263 43069-43073 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15264 43225-43229 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15265 44790-44794 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15266 40486-40508 http://purl.obolibrary.org/obo/GO_1900745 denotes activation of p38 MAPK
T15267 40524-40539 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15268 42934-42949 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15269 44816-44831 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T15270 41323-41344 http://purl.obolibrary.org/obo/GO_0005049 denotes binding of importin-α
T15271 41843-41857 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T15272 41885-41896 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T15273 42306-42323 http://purl.obolibrary.org/obo/GO_0006412 denotes protein synthesis
T15274 42314-42323 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T15275 44751-44760 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T15276 43426-43438 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15277 44554-44566 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15278 45022-45034 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T15279 44679-44693 http://purl.obolibrary.org/obo/GO_0017038 denotes import protein
T15280 45328-45339 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T16601 24370-24385 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T16602 24406-24420 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T16603 24766-24778 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T16604 24985-24989 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T16605 25212-25214 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T17414 26812-26826 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T17415 28038-28057 http://purl.obolibrary.org/obo/GO_0002672 denotes cells stimulated (b
T17416 28038-28057 http://purl.obolibrary.org/obo/GO_0045579 denotes cells stimulated (b
T17417 28038-28057 http://purl.obolibrary.org/obo/GO_0002869 denotes cells stimulated (b
T17418 28038-28057 http://purl.obolibrary.org/obo/GO_0002904 denotes cells stimulated (b
T17419 28038-28057 http://purl.obolibrary.org/obo/GO_0050871 denotes cells stimulated (b
T17420 28038-28057 http://purl.obolibrary.org/obo/GO_0031296 denotes cells stimulated (b
T17421 28038-28057 http://purl.obolibrary.org/obo/GO_0030890 denotes cells stimulated (b
T18100 29449-29452 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18101 29705-29708 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18102 29881-29884 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18103 29709-29713 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18104 29885-29889 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18105 29933-29937 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18106 29464-29479 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18107 29556-29571 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18108 29653-29668 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18109 29807-29822 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18110 30026-30041 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18111 29464-29494 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation and activation
T18112 29807-29835 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation of activated
T18113 29528-29538 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T18114 29826-29856 http://purl.obolibrary.org/obo/GO_0051091 denotes activated transcription factor
T18115 29826-29856 http://purl.obolibrary.org/obo/GO_0032793 denotes activated transcription factor
T18116 29826-29856 http://purl.obolibrary.org/obo/GO_1901485 denotes activated transcription factor
T18117 29836-29849 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T18118 29915-29937 http://purl.obolibrary.org/obo/GO_1903753 denotes inhibition of p38 MAPK
T18536 31655-31673 http://purl.obolibrary.org/obo/GO_0005049 denotes importin-α binding
T19149 33308-33322 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T19150 33367-33381 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T19151 33506-33518 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T19152 25526-33640 http://purl.obolibrary.org/obo/GO_0031296 denotes stimulated. (E) FP (10 nM) reduces the ability of anti-CD3/CD28-stimulated GATA-3 to associate with the native IL-5 promoter 60 min after stimulation. Data are also shown graphically as mean±SEM of three independent experiments. All data were analysed by ANOVA followed by Newman-Keuls post-test. Ligand-Activated GR Competes with GATA-3 for Importin-α We confirmed and extended previous data [20] to show that ligand-activated GR as well as GATA-3 uses importin-α for its nuclear import (Figure 2A and 2B). This interaction between GR and importin-α was significant at concentrations as low as 10−12 M and was maximal with 10−8 M FP. Subsequent GR nuclear translocation was rapid and sustained at significant levels for at least 14 h (Figure 2B). Using IP-Western blotting we showed that FP at 10−12–10−8 M decreased the association between GATA-3 and importin-α induced by anti-CD3/CD28 stimulation in a concentration-dependent manner (Figure 2C). In addition, using GFP-labelled GATA-3 and confocal microscopy we demonstrated that GATA-3 nuclear import following anti-CD3/CD28 stimulation for 30 min was attenuated by pretreatment with FP (10−8 M) (Figure 2D). 10.1371/journal.pmed.1000076.g002 Figure 2 Fluticasone propionate reduces GATA-3 association with importin-α and GATA-3 nuclear import. (A) Western blot analysis demonstrates a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR interaction with importin-α (Imp-α). A positive control for GR association with importin is shown. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. *** p<0.001 compared to control, ### p<0.001. (B) Western blot analysis demonstrated a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR nuclear translocation measured by IP. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. ***p<0.001 compared to control. (C) Western blot analysis of HuT-78 cells treated with FP and anti-CD3/CD28 co-stimulation demonstrated a concentration-dependent decrease in GATA-3–importin-α association at 20 min. Quantification of the densitometry data is shown below. Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) GFP-tagged GATA-3 was overexpressed and cells stimulated (b, c) or not (a) for 30 min with anti-CD3/CD28. The effect of 30 min pretreatment of cells with FP (10−8 M, c) is also shown. All data were analysed by ANOVA followed by Newman-Keuls post-test. Effect on MKP-1 Dexamethasone inhibits p38 MAPK function in a cell type–specific manner through the rapid induction of the dual kinase phosphatase MKP-1 (MAPK phosphatase-1), and this effect lasts for up to 24 h [28]. FP (10−8 M) treatment of HuT-78 cells activated by anti-CD3/CD28 in vitro significantly decreased p38 MAPK phosphorylation (Figure 3A) and activity measured by phosphorylation of the downstream target ATF-2 (Figure 3B). This effect was detected at 30 min and lasted for at least 14 h (Figure 3B). FP (10−8 M) also significantly reduced GATA-3 serine phosphorylation induced by anti-CD3/CD28 stimulation in both a time- and concentration-dependent manner (Figure 3C). This reduction in GATA-3 phosphorylation was also seen with lower concentrations of FP. We found that FP significantly induced MKP-1 mRNA in both a time- and concentration-dependent manner, reaching a plateau at 10−8 M after 10 min (Figure 3D and 3E). However, the effects of FP on GATA-3 nuclear import, importin-α association and IL-4 mRNA expression are seen at 10,000-fold lower concentrations (10−12 M, see Figure 2). 10.1371/journal.pmed.1000076.g003 Figure 3 Fluticasone propionate–mediated inhibition of p38 MAP kinase phosphorylation and activation is associated with a marked down-regulation of GATA-3 serine phosphorylation. (A) Western blot analysis shows that FP (10−8 M, 30 min) treatment reduced dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK in anti-CD3/CD28–co-stimulated HuT-78 cells. (B) Time course of the effect of FP (10−8 M) on phosphorylation of activated transcription factor 2 (ATF-2), a measure of p38 MAPK activity. (C) FP-induced inhibition of p38 MAPK activity is associated with the decrease of anti-CD3/CD28 co-stimulation–induced serine phosphorylation (P-Ser) of GATA-3. For (A–C), quantification of the densitometry data is also shown. Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) FP induced MKP-1 mRNA in a concentration-dependent manner. All results are representative of at least three independent experiments and where appropriate expressed as means±SEM, *p<0.05. (E) FP induces MKP-1 mRNA in a time-dependent manner. Results are representative of two independent experiments. All data except (E) were analysed by ANOVA followed by Newman-Keuls post-test. Using an in vitro competition assay (Figure 4A) utilizing purified activated GATA-3, importin-α, and activated GR, we demonstrated that activated GR significantly increased GR-importin-α association in the presence and absence of activated GATA-3 (Figure 4B). This effect is not mutual, since activated GATA-3 did not block GR–importin-α association (Figure 4C). These data also suggest that both activated GR and phospho-GATA-3 can directly associate with importin-α (Figure 4D) and that activated GR attenuates the phospho-GATA-3/importin-α interaction in a concentration-dependent manner (Figure 4E). Together, this suggests that ligand-activated GR may compete with phospho-GATA-3 for importin-α and thereby limit GATA-3 nuclear import. 10.1371/journal.pmed.1000076.g004 Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α. (A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p<0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p<0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p<0.05 compared to GATA-3 isolated from unstimulated cells. # p<0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p<0.05, **p<0.01 between groups. All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test. Other possible interpretations of our results could include an effect of FP on GATA-3 nuclear export and/or degradation. Leptomycin B, which inhibits nuclear export, did not affect the ability of FP to block GATA-3 nuclear localization (Figure 5A). Additionally, FP had no effect on whole cell GATA-3 expression during the time course of these experiments (Figure 5B). Nor did addition of FP subsequent to anti-CD3/CD28 nuclear translocation affect GATA-3 nuclear residency (Figure 5C), suggesting that activated GR does not enhance GATA-3 nuclear export. Finally, the effect of FP on GATA-3 nuclear import was not nonspecific, since FP (10−8 M) had no effect on p65 nuclear translocation measured at 60 min (Figure 5D). 10.1371/journal.pmed.1000076.g005 Figure 5 Fluticasone propionate does not affect GATA-3 nuclear export. (A) Western blot analysis showing that the nuclear export inhibitor leptomycin B (2 nM) does not affect the ability of FP (10−8 M) to prevent anti-CD3/CD28–stimulated GATA-3 nuclear localization measured at 60 min. ***p<0.001 compared to unstimulated cells, ### p<0.001 compared to anti-CD3/CD28–stimulated cells. (B
T19153 33789-33808 http://purl.obolibrary.org/obo/GO_0031296 denotes cells stimulated (b
T19154 33723-33734 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T19155 33789-33808 http://purl.obolibrary.org/obo/GO_0002672 denotes cells stimulated (b
T19156 33789-33808 http://purl.obolibrary.org/obo/GO_0045579 denotes cells stimulated (b
T19157 33789-33808 http://purl.obolibrary.org/obo/GO_0002869 denotes cells stimulated (b
T19158 33789-33808 http://purl.obolibrary.org/obo/GO_0002904 denotes cells stimulated (b
T19159 33789-33808 http://purl.obolibrary.org/obo/GO_0050871 denotes cells stimulated (b
T19160 33789-33808 http://purl.obolibrary.org/obo/GO_0030890 denotes cells stimulated (b
T19579 34874-34886 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T20243 38030-38042 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T20244 38162-38174 http://purl.obolibrary.org/obo/GO_0051179 denotes localisation
T20245 39244-39259 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T20246 39296-39299 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T20247 39300-39304 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T754 22-36 http://purl.obolibrary.org/obo/GO_0051170 denotes Nuclear Import
T755 1346-1362 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear importer
T756 41-56 http://purl.obolibrary.org/obo/GO_0016310 denotes Phosphorylation
T3225 7246-7258 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammation
T3226 7549-7561 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3227 7887-7899 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3228 9492-9504 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

GO-MF

Id Subject Object Predicate Lexical cue
T770 554-559 http://purl.obolibrary.org/obo/GO_0005136 denotes IL)-4
T771 561-565 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T772 571-576 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T773 1271-1277 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T774 1434-1458 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T775 1460-1464 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T776 1517-1520 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T777 1466-1477 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T3290 10877-10898 http://purl.obolibrary.org/obo/GO_0050693 denotes ligand-binding domain
T3291 11108-11121 http://purl.obolibrary.org/obo/GO_0003755 denotes immunophilins
T3292 11136-11149 http://purl.obolibrary.org/obo/GO_0005528 denotes FK506-binding
T3293 11142-11158 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T3294 11181-11187 http://purl.obolibrary.org/obo/GO_0003777 denotes dynein
T3295 11525-11528 http://purl.obolibrary.org/obo/GO_0004096 denotes CAT
T3296 12138-12148 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4300 13181-13191 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4301 13304-13314 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4302 13469-13479 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4303 13701-13711 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T4304 13798-13806 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T4305 13496-13499 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T4834 14854-14856 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T4835 14914-14916 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T4836 14968-14972 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T5181 15616-15624 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T5452 16245-16259 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T5453 16391-16395 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T6017 17283-17291 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T6018 17594-17604 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T6019 17728-17738 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T6249 18050-18063 http://purl.obolibrary.org/obo/GO_0051059 denotes NF-κB binding
T6250 18056-18063 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T6251 18363-18370 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T6252 18344-18352 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T6253 18416-18424 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T6714 18934-18942 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T6715 19111-19119 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T6716 19545-19555 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T6717 19570-19584 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T8660 23238-23242 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T8661 23309-23313 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T8662 24163-24167 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T8663 24172-24176 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T8664 24248-24252 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T8665 24226-24233 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T9280 25824-25830 http://purl.obolibrary.org/obo/GO_0005488 denotes Ligand
T9281 25938-25944 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T10707 28290-28293 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T10708 28294-28298 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10709 28405-28409 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10710 28571-28575 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T10711 28386-28397 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10712 28410-28421 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T10713 29268-29272 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T10714 31301-31307 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T12589 35764-35768 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T12590 37831-37834 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T12591 37835-37839 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T12592 39693-39697 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15296 40504-40508 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15297 42571-42575 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15298 42650-42654 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15299 42898-42902 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15300 43069-43073 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15301 43225-43229 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15302 44790-44794 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15303 40939-40943 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15304 43522-43526 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15305 43693-43697 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15306 44352-44356 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T15307 40944-40948 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T15308 44361-44365 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T15309 41210-41216 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T15310 41323-41330 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15311 44649-44656 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15312 41323-41344 http://purl.obolibrary.org/obo/GO_0005049 denotes binding of importin-α
T16606 24985-24989 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK1
T16607 25212-25214 http://purl.obolibrary.org/obo/GO_0003964 denotes RT
T16608 25244-25248 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T16609 25253-25257 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T16610 25637-25641 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T18119 29449-29452 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18120 29705-29708 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18121 29881-29884 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T18122 29709-29713 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18123 29885-29889 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18124 29933-29937 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T18125 29826-29856 http://purl.obolibrary.org/obo/GO_0033613 denotes activated transcription factor
T18537 31566-31573 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18538 31666-31673 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18539 32063-32070 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18540 32187-32194 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18541 31655-31673 http://purl.obolibrary.org/obo/GO_0005049 denotes importin-α binding
T20250 39296-39299 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T20251 39300-39304 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T15289 40420-40423 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15290 40500-40503 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15291 42567-42570 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15292 42894-42897 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15293 43065-43068 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15294 43221-43224 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T15295 40424-40428 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T3269 7385-7390 http://purl.obolibrary.org/obo/GO_0005136 denotes IL)-4
T3270 7787-7792 http://purl.obolibrary.org/obo/GO_0005136 denotes 4, IL
T3271 11369-11374 http://purl.obolibrary.org/obo/GO_0005136 denotes 4, IL
T3272 7392-7396 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3273 7511-7515 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3274 7790-7794 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3275 11372-11376 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3276 11617-11621 http://purl.obolibrary.org/obo/GO_0005137 denotes IL-5
T3277 7402-7407 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T3278 7446-7451 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T3279 7800-7805 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T3280 11382-11387 http://purl.obolibrary.org/obo/GO_0005144 denotes IL-13
T3281 9243-9246 http://purl.obolibrary.org/obo/GO_0004707 denotes p38
T3282 9281-9285 http://purl.obolibrary.org/obo/GO_0004707 denotes MAPK
T3283 9255-9279 http://purl.obolibrary.org/obo/GO_0030295 denotes activated protein kinase
T3284 9652-9659 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3285 10884-10891 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3286 10735-10742 http://purl.obolibrary.org/obo/GO_0005488 denotes ligands
T3287 10877-10883 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T3288 9652-9687 http://purl.obolibrary.org/obo/GO_0035259 denotes binding to glucocorticoid receptors
T3289 10220-10250 http://purl.obolibrary.org/obo/GO_0008139 denotes nuclear localisation sequences

GO-CC

Id Subject Object Predicate Lexical cue
T778 599-604 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T779 1005-1010 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3311 9084-9089 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3312 11483-11488 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4306 13181-13191 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T4307 13304-13314 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T4308 13469-13479 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T4309 13701-13711 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T4310 13798-13806 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T4311 13181-13191 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T4312 13304-13314 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T4313 13469-13479 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T4314 13701-13711 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T4315 13798-13806 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T4316 13534-13538 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T5182 15127-15131 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T5183 15278-15282 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T5184 15616-15624 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T5185 15616-15624 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T5454 16054-16063 http://purl.obolibrary.org/obo/GO_0000785 denotes Chromatin
T5455 16084-16093 http://purl.obolibrary.org/obo/GO_0000785 denotes Chromatin
T5456 16174-16179 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6020 16837-16842 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6021 16984-16989 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6022 16993-16998 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6023 17103-17108 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6024 17373-17378 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6025 17482-17487 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6026 17283-17291 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T6027 17594-17604 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T6028 17728-17738 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T6029 17283-17291 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T6030 17594-17604 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T6031 17728-17738 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T6254 18344-18352 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T6255 18416-18424 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T6256 18344-18352 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T6257 18416-18424 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T6718 18934-18942 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T6719 19111-19119 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T6720 19545-19555 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T6721 19606-19616 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T6722 18934-18942 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T6723 19111-19119 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T6724 19545-19555 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T6725 19606-19616 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T6726 19027-19032 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6727 19696-19701 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6728 19251-19260 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T7341 20743-20748 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7342 20859-20864 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7343 21083-21088 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7344 21140-21144 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T7597 21202-21207 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7598 21610-21612 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T8666 23480-23485 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12593 35709-35713 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T12594 36908-36913 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12595 37110-37115 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12596 37869-37874 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16614 24510-24519 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T16615 24527-24534 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T18542 31637-31642 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18543 31819-31824 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18544 32002-32007 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18545 32132-32137 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15313 40460-40464 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T15314 41080-41085 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15315 42747-42752 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15316 44028-44033 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15317 44396-44401 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T15318 40694-40703 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T15319 40711-40718 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T17422 27635-27640 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17423 27987-27992 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17424 28038-28043 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10715 28313-28317 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T10716 32786-32790 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T16611 24460-24465 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16612 24730-24735 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16613 25299-25304 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T17425 28141-28146 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18126 29752-29757 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18127 27987-27992 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19161 33575-33580 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19162 33631-33636 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19163 33789-33794 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19164 33866-33871 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T19165 34100-34105 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3306 7430-7435 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3307 7683-7688 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3308 8372-8377 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3309 8693-8698 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3310 8742-8747 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3313 11664-11669 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3314 12096-12101 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3315 12285-12290 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3316 7814-7823 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T3317 8528-8537 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T3318 8547-8554 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3319 8891-8898 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3320 9412-9419 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3321 9725-9732 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3322 10712-10719 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3323 10008-10045 http://purl.obolibrary.org/obo/GO_0044798 denotes transcription factors such as nuclear
T3324 10343-10354 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosomal
T3325 10343-10361 http://purl.obolibrary.org/obo/GO_0098687 denotes chromosomal region
T3326 12138-12148 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T3327 12138-12148 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T4600 13960-13964 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T4601 14069-14073 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell

sentences

Id Subject Object Predicate Lexical cue
T1295 7246-7436 Sentence denotes Inflammation in allergic diseases such as asthma, rhinitis, and atopic dermatitis is mediated via expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells.
T1296 7437-7566 Sentence denotes IL-4 and IL-13 regulate the expression of IgE from B lymphocytes, whereas IL-5 plays a key role in eosinophilic inflammation [1].
T1297 7567-7697 Sentence denotes Th2 cytokines are regulated by the zinc finger transcription factor GATA-3, which is predominantly expressed in Th2 cells [2],[3].
T1298 7698-7844 Sentence denotes GATA-3 determines Th2 cell differentiation and selectively activates the promoters of IL-4, IL-5, and IL-13 through chromatin remodelling [4]–[7].
T1299 7845-8103 Sentence denotes The key role of GATA-3 in allergic airway inflammation has been demonstrated in mice by the reduced release of Th2 cytokines in animals treated with dominant-negative mutants of GATA-3 and by local application of antisense oligonucleotides to GATA-3 [8],[9].
T1300 8104-8308 Sentence denotes Furthermore, conditional knock-out of the Gata3 gene in mice reduces expression of Th2 cytokines in vitro and in vivo [10], and similar results have been reported in isolated murine CD4+ lymphocytes [11].
T1301 8309-8449 Sentence denotes Finally, knockdown of GATA-3 expression using siRNA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].
T3670 12350-12379 Sentence denotes Participants and Study Design
T3671 12380-12577 Sentence denotes We studied patients with mild asthma who were not treated with inhaled corticosteroids who had been included in a previously reported double-blind, placebo-controlled, crossover study with FP [34].
T3672 12578-12827 Sentence denotes Seven patients with mild asthma entered the study and were randomized to receive a single inhalation of FP (100 and 500 µg) or a matched placebo control via a spacer chamber, and the other treatment was given after a wash-out period of at least 6 d.
T3673 12828-12908 Sentence denotes Blood was taken for preparation of PBMCs at 1 and 2 h after drug administration.
T3674 12909-13140 Sentence denotes All patients gave informed consent and the study was approved by the Ethics Committee of the Royal Brompton and Harefield Hospitals NHS Trust. The clinical study was conducted before the requirement for Clinical Trial Registration.
T3976 13142-13165 Sentence denotes Antibodies and Reagents
T3977 13166-13296 Sentence denotes The monoclonal antibodies against human CD3, CD28, GR, and importin-α were purchased from BD Biosciences (Oxford, United Kingdom).
T3978 13297-13785 Sentence denotes Rabbit antibodies against human GATA-3 (H-48) and GR (E-20, sc-1003) were obtained from Santa Cruz Biotechnology (Santa Cruz, California, United States), polyclonal rabbit antibodies against phospho-p38 MAP kinase and phospho-ATF-2 from Cell Signaling Technology (New England Biolabs, Hertford, UK), monoclonal antibody against phosphoserine (clone 4H4) from Affiniti Research Products (Exeter, UK), and antibodies against rabbit IgG-conjugated TRITC from Dako Cytomation (Cambridge, UK).
T3979 13786-13900 Sentence denotes The anti-GR antibody (Clone 41) from BD Transduction Laboratories (Oxford, UK) was used for Western blot analysis.
T3980 13901-13958 Sentence denotes All other reagents were purchased from Sigma (Poole, UK).
T4615 14566-14591 Sentence denotes Reverse Transcription PCR
T4616 14592-14669 Sentence denotes Total RNA was extracted using lysis buffer (RNeasy kit; Qiagen, Crawley, UK).
T4617 14670-14765 Sentence denotes During RNA purification, genomic DNA was digested with RNase-free DNase (Amersham Biosciences).
T4618 14766-14884 Sentence denotes Next, 0.5 µg of total RNA was reversed transcribed using the avian myeloblastosis virus RT (Promega, Southampton, UK).
T4619 14885-14955 Sentence denotes For relative quantification, RT-PCR was carried out using cDNA probes.
T4620 14956-15013 Sentence denotes Primers for IL-4 were from Sigma-Genosys (Cambridge, UK).
T4621 15014-15125 Sentence denotes Sequences of GADPH used are as follows: forward 5′-CCACCCATGGCAAATTCCATGGC, reverse 3′-TCTAGACGGCAGGTCAGGTCCAC.
T4846 15127-15193 Sentence denotes Cell Fractionation, Immunoprecipitation, and Western Blot Analysis
T4847 15194-15271 Sentence denotes Nuclear and cytoplasmic fractions were prepared as previously described [35].
T4848 15272-15441 Sentence denotes Whole cell lysates were prepared in NP-40 lysis buffer (0.5% Nonidet P-40, 20 mM Tris-HCl [pH 7.5], 150 mM NaCl) in the presence of complete protease cocktail inhibitor.
T4849 15442-15557 Sentence denotes Lysates were centrifuged at 4°C for 10 min at 12,000 rpm in an Eppendorf microcentrifuge to remove cellular debris.
T4850 15558-15809 Sentence denotes Samples were then immunoprecipitated with either 10 µl of antibody against GATA-3 or importin-α using A/G agarose slurry in the presence of protease inhibitor using the Catch and Release methodology (Upstate Biotechnology, Lake Placid, New York, USA).
T4851 15810-15946 Sentence denotes Western blot analysis was performed using anti-GATA-3, anti-importin-α, anti-GR, anti-p-p38 MAP kinase, anti-p-ATF-2, and anti-p-serine.
T4852 15947-16052 Sentence denotes Immunoreactive proteins were detected using an enhanced chemiluminescence ECL kit (Amersham Biosciences).
T5202 16054-16083 Sentence denotes Chromatin Immunoprecipitation
T5203 16084-16467 Sentence denotes Chromatin immunoprecipitation (IP) was performed as previously described [12] in HuT-78 T-cells with 2 µg of anti-GATA-3 (Santa Cruz Biotechnology), or isotypic immunoglobulin G as a non-specific control (Santa Cruz Biotechnology) overnight at 4°C. Promoter sequences were detected with PCR primers for the IL-5 promoter (−445 to +4): forward 5′-TTAATCTAGCCACAGTCATAG-3′ and reverse:
T5204 16468-16496 Sentence denotes 5′-TCATGGCTCTGAAACGTTCTG-3′.
T5205 16497-16677 Sentence denotes PCR was performed using a Hybaid Omnigene thermal cycler (Hybaid, Ashford, UK) with cycling parameters of 72°C for 10 min, 35 cycles at 94°C for 45 s, 52°C for 45 s, 72°C for 45 s.
T5489 16679-16750 Sentence denotes GR-GATA-3 In Vitro Competition Assay for Importin-α (Far-Western ELISA)
T5490 16751-16926 Sentence denotes Immunoprecipitated importin-α (anti-importin-α, Santa Cruz Biotechnology) from HuT-78 cells was separated by SDS-PAGE and purified from the excised gel by electroelution [36].
T5491 16927-17109 Sentence denotes Similarly, GATA-3 was isolated from nonstimulated HuT-78 cells or cells stimulated for 30 min with anti-CD3/CD28 and GR was isolated from FP (10−8 M, 30 min) stimulated HuT-78 cells.
T5492 17110-17172 Sentence denotes These proteins were subsequently refolded in glycine solution.
T5493 17173-17292 Sentence denotes 100 µl of importin-α solution (100 ng/ml in TBS) was added to 96-well plates coated with goat anti-importin-α antibody.
T5494 17293-17421 Sentence denotes After 1 h incubation, GATA-3 (100 ng/ml in TBS) from stimulated or unstimulated cells were added to the importin-α-coated wells.
T5495 17422-17513 Sentence denotes GR (10 or 100 ng/ml in TBS) from stimulated or unstimulated cells were added to some wells.
T5496 17514-17739 Sentence denotes After a further 1 h incubation, the plate was washed and incubated with primary antibodies (a mixture of rabbit anti-GATA-3 and mouse anti-GR, Santa Cruz Biotechnology) for 1.5 h, and then incubated with secondary antibodies.
T5497 17740-17930 Sentence denotes FITC swine anti-rabbit IgG (Dako, Cambridge, UK) was used for the detection of GATA-3, and rhodamine donkey anti-mouse IgG (Novus, Littleton, Colorado, USA) was used for the detection of GR.
T5498 17931-18031 Sentence denotes FITC and rhodamine levels were measured with a fluorescent micro-plate reader (Bioline, London, UK).
T6074 18033-18049 Sentence denotes NF-κB Activation
T6075 18050-18182 Sentence denotes NF-κB binding activity in nuclear extracts was determined using an ELISA-based kit (Trans-AM p65, Active Motif, Rixensart, Belgium).
T6076 18183-18293 Sentence denotes In brief, 5 µg of nuclear extracts were incubated with a plate coated with an NF-κB consensus oligonucleotide.
T6077 18294-18353 Sentence denotes Plates were washed before addition of an anti-p65 antibody.
T6078 18354-18458 Sentence denotes Antibody binding was detected with a secondary HRP-conjugated antibody and developed with TMB substrate.
T6079 18459-18512 Sentence denotes The intensity of the reaction was measured at 450 nm.
T6273 18514-18541 Sentence denotes Immunofluorescence Staining
T6274 18542-18613 Sentence denotes Immunofluorescence staining was performed as previously described [34].
T6275 18614-18686 Sentence denotes All staining was performed at room temperature and under humidification.
T6276 18687-18786 Sentence denotes Cells were collected and cytospins prepared in a cytocentrifuge (Shandon II, Shandon, Runcorn, UK).
T6277 18787-18971 Sentence denotes Cells were permeabilized, blocked, and then incubated with GR (1∶50 E-20 Santa Cruz Biotechnology) or anti-GATA-3 (H-48; Santa Cruz Biotechnology) antibody for 1 h at room temperature.
T6278 18972-19127 Sentence denotes After three washes in phosphate-buffered saline (PBS), cells were incubated with tetrarhodamine isothiocyanate–conjugated goat anti-rabbit antibody (Dako).
T6279 19128-19304 Sentence denotes Cytospins were counterstained with 4′,6-diamidino-2-phenylindole dihydrochloride (DAPI), a fluorescent blue nuclear indole chromatin stain, and mounted in PBS:glycerol (50∶50).
T6280 19305-19508 Sentence denotes The immunopositive signal was characterised using laser scanning confocal microscopy on a Leica TCS NT/SP interactive laser cytometer equipped with confocal optics (Leica Microsystems, Wetzlar, Germany).
T6281 19509-19659 Sentence denotes To determine the specificity of the antibodies, rabbit serum immunoglobulin (Dako) and secondary antibodies without the primary were used as controls.
T6282 19660-19778 Sentence denotes Positively stained nuclei and total cells were counted (500) on each slide with the observer blinded to the treatment.
T7169 20723-20735 Sentence denotes Transfection
T7170 20736-21007 Sentence denotes HuT-78 cells were transfected with either EP8 or GFP vector only DNA using solution R, programme V-001 at a ratio of 3×106 cells/4 µg DNA for 7–8 h in complete medium (10% bovine serum in RPMI1640+15 L-glutamine) according to the general Amaxa protocol for nucleofection.
T7171 21008-21171 Sentence denotes The medium was subsequently changed to 1% RPMI for 24 h before transfected cells were added to anti-CD3/CD28 treated wells and live cell videomicroscopy performed.
T7353 21173-21194 Sentence denotes Time-Lapse Microscopy
T7354 21195-21463 Sentence denotes HuT-78 cells expressing GATA-3-GFP were maintained at 37°C in growth medium in a closed FCS2 perfusion chamber (Bioptechs, Butler, Pennsylvania, USA) combined with an objective heater (Bioptechs) on the stage a Zeiss Axiovert 200 microscope (Thornwood, New York, USA).
T7355 21464-21729 Sentence denotes Observations were made by 40×1.0 NA oil-immersion objective lens, and fluorescence and phase contrast images were gathered using a Hamamatsu ORCA-ER charged coupled device camera (Bridgewater, New Jersey, USA) driven by Openlab software (Improvision, Coventry, UK).
T7356 21730-21784 Sentence denotes Photographs were taken at 0, 30, 60, 120, and 240 min.
T7605 21786-21808 Sentence denotes Densitometric Analysis
T7606 21809-21938 Sentence denotes Densitometry of ECL immunoblots was performed using Gelworks ID intermediate software (Ultraviolet Products, Cambridgeshire, UK).
T7607 21939-22019 Sentence denotes Briefly, immunoblots were scanned and gates were drawn tightly around each band.
T7608 22020-22099 Sentence denotes Background values from each lane were subtracted to normalize each measurement.
T7609 22100-22154 Sentence denotes The bands were quantified using the Gelworks software.
T7610 22155-22326 Sentence denotes All Western blots were exposed to film for varying lengths of time, and only films generating subsaturating levels of intensity were selected for densitometric evaluation.
T7781 22328-22348 Sentence denotes Statistical Analysis
T7782 22349-22563 Sentence denotes Data from three or more independent experiments are presented as the mean±standard error of the mean (SEM), except where stated and were compared using GraphPad Prism 4 (GraphPad Software, http://www.graphpad.com).
T7783 22564-22787 Sentence denotes Results were analysed using one-way ANOVA with Newman-Keuls post test except for the data from the in vivo inhaled FP study, which was analysed by Friedman's test with subsequent Wilcoxson matched pair signed rank sum test.
T7784 22788-22853 Sentence denotes Data from this analysis are presented as a box-and-whiskers plot.
T7785 22854-23003 Sentence denotes Friedman's test was used as three matched measures were obtained using placebo, 100 µg, and 500 µg of inhaled FP, which had variable baseline levels.
T7786 23004-23161 Sentence denotes We did not assume a Gaussian distribution of the data due to the limited numbers of participants analysed (seven).The null hypothesis was rejected at p<0.05.
T8238 23172-23247 Sentence denotes The Effect of Corticosteroids on GATA-3 Nuclear Translocation and IL-4 mRNA
T8239 23248-23356 Sentence denotes Corticosteroids are effective in inhibiting GATA-3-regulated IL-4 gene expression in vitro and in vivo [32].
T8240 23357-23464 Sentence denotes We therefore investigated whether corticosteroids affect anti-CD3/CD28–stimulated nuclear import of GATA-3.
T8241 23465-23616 Sentence denotes Stimulation of cells with anti-CD3/CD28 resulted in a rapid cytoplasmic/nuclear GATA-3 translocation (Figure 1A), confirming our previous results [12].
T8242 23617-23746 Sentence denotes We also confirmed a clear separation of nuclear and cytosolic fractions as indicated by histone H1 and MEK-1 markers (Figure 1B).
T8243 23747-23958 Sentence denotes The potent topical corticosteroid FP caused sustained loss of nuclear GATA-3 expression and cytoplasmic retention of GATA-3 at concentrations ranging from 10−12 to 10−8 M, which cover the therapeutic range [37].
T8244 23959-24274 Sentence denotes This effect was concentration- and time-dependent, with a peak effect of 11.6-fold at 30 min at a concentration of 10−8 M (Figure 1C) and was associated with marked reductions in anti-CD3/CD28–stimulated IL-4 and IL-5 mRNA expression (Figure 1D) and a loss of GATA-3 binding to the native IL-5 promoter (Figure 1E).
T8940 25824-25879 Sentence denotes Ligand-Activated GR Competes with GATA-3 for Importin-α
T8941 25880-26034 Sentence denotes We confirmed and extended previous data [20] to show that ligand-activated GR as well as GATA-3 uses importin-α for its nuclear import (Figure 2A and 2B).
T8942 26035-26161 Sentence denotes This interaction between GR and importin-α was significant at concentrations as low as 10−12 M and was maximal with 10−8 M FP.
T8943 26162-26274 Sentence denotes Subsequent GR nuclear translocation was rapid and sustained at significant levels for at least 14 h (Figure 2B).
T8944 26275-26476 Sentence denotes Using IP-Western blotting we showed that FP at 10−12–10−8 M decreased the association between GATA-3 and importin-α induced by anti-CD3/CD28 stimulation in a concentration-dependent manner (Figure 2C).
T8945 26477-26690 Sentence denotes In addition, using GFP-labelled GATA-3 and confocal microscopy we demonstrated that GATA-3 nuclear import following anti-CD3/CD28 stimulation for 30 min was attenuated by pretreatment with FP (10−8 M) (Figure 2D).
T9693 30668-30927 Sentence denotes Using an in vitro competition assay (Figure 4A) utilizing purified activated GATA-3, importin-α, and activated GR, we demonstrated that activated GR significantly increased GR-importin-α association in the presence and absence of activated GATA-3 (Figure 4B).
T9694 30928-31030 Sentence denotes This effect is not mutual, since activated GATA-3 did not block GR–importin-α association (Figure 4C).
T9695 31031-31271 Sentence denotes These data also suggest that both activated GR and phospho-GATA-3 can directly associate with importin-α (Figure 4D) and that activated GR attenuates the phospho-GATA-3/importin-α interaction in a concentration-dependent manner (Figure 4E).
T9696 31272-31408 Sentence denotes Together, this suggests that ligand-activated GR may compete with phospho-GATA-3 for importin-α and thereby limit GATA-3 nuclear import.
T9697 32497-32617 Sentence denotes Other possible interpretations of our results could include an effect of FP on GATA-3 nuclear export and/or degradation.
T9698 32618-32745 Sentence denotes Leptomycin B, which inhibits nuclear export, did not affect the ability of FP to block GATA-3 nuclear localization (Figure 5A).
T9699 32746-32865 Sentence denotes Additionally, FP had no effect on whole cell GATA-3 expression during the time course of these experiments (Figure 5B).
T9700 32866-33052 Sentence denotes Nor did addition of FP subsequent to anti-CD3/CD28 nuclear translocation affect GATA-3 nuclear residency (Figure 5C), suggesting that activated GR does not enhance GATA-3 nuclear export.
T9701 33053-33217 Sentence denotes Finally, the effect of FP on GATA-3 nuclear import was not nonspecific, since FP (10−8 M) had no effect on p65 nuclear translocation measured at 60 min (Figure 5D).
T11291 34269-34385 Sentence denotes The Inhibitory Effect of Corticosteroids on GATA-3 Nuclear Localization in Primary T Lymphocytes Ex Vivo and In Vivo
T11292 34386-34744 Sentence denotes Treatment with FP ex vivo demonstrated a concentration-dependent decrease in the direct interaction between phospho-GATA-3 and importin-α in PBMCs from patients with asthma (Figure 6A and 6B), which was significantly inhibited at 10−12 M FP (p<0.001, ANOVA and Newman-Keuls test) and completely attenuated by 10−8 M FP (p<0.001, ANOVA and Newman-Keuls test).
T11293 35694-35872 Sentence denotes Our previous T cell line studies indicated that 10−12 M FP suppresses IL-4 and -5 gene expression and attenuated the interaction of GATA-3 with importin-α (see Figures 1D and 2).
T11294 35873-35994 Sentence denotes This concentration is close to peak plasma levels obtained from asthmatic patients treated with inhaled FP (500 µg) [27].
T11295 35995-36151 Sentence denotes Inhaled FP (500 µg) treatment of seven steroid-naive asthma patients significantly reduced GATA-3–importin-α interaction in vivo in a time-dependent manner.
T11296 36152-36314 Sentence denotes This produced a >90% decrease in GATA-3–importin-α association at 2 h (median [95% CI], 13,494 [6,828–17,829] versus 879 [597–1,165]; p<0.05 Friedman's analysis).
T11297 36315-36447 Sentence denotes However, this did not reach significance using Wilcoxon's post-test analysis (W = 6.00) probably due to low numbers of participants.
T11298 36448-36545 Sentence denotes Similar results were observed when GATA-3–importin-α association was measured (Figure 6C and 6D).
T11299 36546-36594 Sentence denotes The lower dose of FP (100 µg) was not effective.
T11300 36595-36801 Sentence denotes The attenuated interaction of GATA-3 did not result from the defective recycling of importin-α, as a significant decrease in the abundance of importin-α in the cytoplasmic pool was not detected (Figure 6E).
T11301 36802-36914 Sentence denotes We further examined whether inhaled FP could affect cellular localization of GATA-3 in peripheral blood T cells.
T11302 36915-37265 Sentence denotes Treatment with inhaled FP (500 µg) for 2 h significantly increased GR nuclear translocation (Figure 7A) and concomitantly decreased the number of nuclear GATA-3 immunoreactive peripheral blood T cells (37%±4.2% versus 58.2%±4.95%, p = 0.016, W = 28.0, Wilcoxon's rank test) compared with placebo as measured by immunocytochemistry (Figure 7A and 7B).
T11303 37266-37397 Sentence denotes This was confirmed by Western blotting, which also indicated that this effect was both time- and dose-dependent (Figure 7C and 7D).
T11304 37398-37795 Sentence denotes Thus, inhaled FP (500 µg) induced significant loss in nuclear GATA-3 at 2 h (median [95% CI], 0.40 [0.27–0.53] versus 0.14 [0.11–0.19], p<0.05, W = 21.00, Wilcoxon's rank test) (Figure 7C) and cytoplasmic GATA-3 levels were enhanced by inhaled FP in a dose-dependent manner (median [95% CI], 0.0032 [0.0026–0.0039] versus 0.658 [0.592–0.720], p<0.05, W = −21.00, Wilcoxon's rank test) (Figure 7D).
T11305 37796-37931 Sentence denotes In addition, FP (500 µg) inhibited p38 MAPK phosphorylation in primary T cells in vivo at 2 h in samples from two patients (Figure 7E).
T11306 39418-39572 Sentence denotes Taken together, our data suggest that inhaled FP reduces nuclear localization of GATA-3 in vivo by acutely inhibiting phospho-GATA-3–importin association.
T11307 39573-39759 Sentence denotes This effect may be direct, through competition for importin-α or associated molecules, or secondary to an effect on p38 MAPK-mediated GATA-3 phosphorylation via rapid induction of MKP-1.
T11308 39760-39907 Sentence denotes The combination of these two interacting effects can result in complete suppression of GATA-3 nuclear import and thus Th2 cytokine gene expression.
T13323 39920-40132 Sentence denotes Here we have demonstrated, to our knowledge for the first time, that corticosteroids may inhibit GATA-3 function and therefore the transcription of Th2 genes via two distinct but interacting molecular mechanisms.
T13324 40133-40312 Sentence denotes Firstly, corticosteroid-activated GR appears to compete with activated GATA-3 for nuclear import via importin-α, which is required for the nuclear transport of both GATA-3 and GR.
T13325 40313-40630 Sentence denotes Secondly, corticosteroids at higher concentrations increase the expression of MKP-1, a potent inhibitor of p38 MAPK activity and thereby prevent T cell receptor/co-receptor activation of p38 MAPK to prevent the phosphorylation of GATA-3 that is necessary for interaction with importin-α and subsequent nuclear import.
T13326 40631-40820 Sentence denotes We have previously shown that translocation of GATA-3 from the cytoplasm to the nucleus involves the nuclear transporter protein importin-α, which interacts with phosphorylated GATA-3 [12].
T13327 40821-41052 Sentence denotes We have also previously reported that GATA-3 knockdown using siRNA results in suppression of anti-CD3/CD28–stimulated IL-4/IL-5 mRNA induction, thus implicating an essential role for GATA-3 in the transcription of these genes [12].
T13328 41053-41154 Sentence denotes We now confirm, in human T cells, that GR also uses the same nuclear import mechanism as GATA-3 [22].
T13329 41155-41268 Sentence denotes We therefore propose that there is competition between ligand-activated GR and phospho-GATA-3 for nuclear import.
T13330 41269-41542 Sentence denotes Furthermore, we have shown that there is preferential binding of importin-α to activated GR over phospho-GATA-3, so that corticosteroids would preferentially reduce GATA-3 entry and thus rapidly switch off Th2 gene transcription without any need for any intermediate steps.
T13331 41543-41702 Sentence denotes Furthermore, there was some degree of specificity for GATA-3, as nuclear translocation of the p65 subunit of NF-κB was not affected by corticosteroid exposure.
T13332 41703-41897 Sentence denotes We tested some alternative explanations for this effect of FP on GATA-3 nuclear exclusion and failed to show that FP either enhances GATA-3 nuclear export directly or induces GATA-3 degradation.
T13333 41898-42104 Sentence denotes The evidence from the in vitro competition assays does, however, suggest that purified activated GR can clearly attenuate purified phospho-GATA-3–importin-α association and that the converse does not occur.
T13334 42105-42187 Sentence denotes Furthermore, we have shown that only phospho-GATA-3 can associate with importin-α.
T13335 42188-42337 Sentence denotes This mechanism is sensitive to very low concentrations of corticosteroid and would be rapid in onset as no changes in protein synthesis are required.
T13336 42338-42537 Sentence denotes This acute mechanism may also contribute to the reduction in GATA-3 nuclear import and may play a major role at low corticosteroid concentrations and/or at early time points prior to MKP-1 induction.
T13337 42538-42674 Sentence denotes Corticosteroids can modulate p38 MAPK activity through the induction of MKP-1, a potent endogenous inhibitor of MAPK function [38],[39].
T13338 42675-42795 Sentence denotes We report here a rapid induction of MKP-1 mRNA following stimulation of cells with relatively high concentrations of FP.
T13339 42796-42989 Sentence denotes We hypothesize that this rapid induction of MKP-1 can reduce GATA-3 nuclear import by attenuating p38 MAPK activity and subsequent GATA-3 phosphorylation, thus preventing nuclear translocation.
T13340 42990-43256 Sentence denotes The location of the serine residue(s) of GATA-3 that are phosphorylated by p38 MAPK are currently unknown, but a bioinformatics search (Motif Scanner, http://scansite.mit.edu/motifscan_seq.phtml) indicates at least three potential p38 MAPK-sensitive serine residues.
T13341 43257-43439 Sentence denotes As predicted from these in vitro data, impairment of GATA-3 nuclear import by FP may, at least in part, underlie the efficacy of corticosteroids in suppressing allergic inflammation.
T13342 43440-43740 Sentence denotes Although we did not assess the acute inhibitory effect of FP on the expression of IL-4 mRNA in vivo, a single inhalation of FP (500 µg) may have comparable effects, as it provides plasma levels within a relevant range of concentrations used to suppress IL-4 transcription in our in vitro system [37].
T13343 43741-43872 Sentence denotes A lower dose of inhaled FP (100 µg) was not effective, but plasma concentrations may be below those required for GATA-3 inhibition.
T13344 43873-44053 Sentence denotes However, it is likely that the higher concentrations of FP in the airways after inhaled administration would be effective in inhibiting GATA-3 in airway T cells of asthma patients.
T13345 44054-44276 Sentence denotes The study of PBMCs from asthma patients treated with inhaled corticosteroid therapy clearly demonstrates that these molecular mechanisms are likely to also occur in patients at therapeutic doses of inhaled corticosteroids.
T13346 44277-44452 Sentence denotes In addition, previous studies have shown that corticosteroids can suppress IL-4 and IL-5 release from peripheral blood cells of asthma patients in vitro and in vivo [40]–[42].
T13347 44453-44896 Sentence denotes In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3.
T13348 44897-45035 Sentence denotes These two mechanisms are likely to be synergistic, accounting for the rapid and potent effect of corticosteroids on allergic inflammation.
T13349 45036-45235 Sentence denotes This is exemplified by the rapid inhibitory effect of topical corticosteroids on nasal Th2 cytokine release after allergen provocation in individuals with seasonal allergic rhinitis (hay fever) [43].
T13350 45236-45398 Sentence denotes Prevention of phospho-GATA-3 interaction with importin-α may provide a new approach for the development of novel therapies for the treatment of allergic diseases.
T16029 24319-24421 Sentence denotes Fluticasone propionate down-regulates Th2 cytokine gene expression and inhibits GATA-3 nuclear import.
T16030 24422-24921 Sentence denotes (A) Anti-CD3/CD28 treatment of HuT-78 cells results in translocation of GATA-3 from the cytoplasm to the nucleus within 30 min. (B) Histone H1 and MEK-1 were used to confirm distinct separation of cytoplasmic and nuclear extracts in three separate experiments. (C) Western blot analysis of FP-treated HuT-78 cells demonstrated impaired nuclear localization of GATA-3 induced by anti-CD3/CD28 co-stimulation in a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent manner.
T16031 24922-24984 Sentence denotes Cells were pretreated with FP for 30 min prior to stimulation.
T16032 24985-25081 Sentence denotes MEK1 and histone H1 were used to demonstrate equal cytoplasmic and nuclear loading respectively.
T16033 25082-25305 Sentence denotes Results are presented graphically below as mean±SEM of at least three independent experiments. *** p<0.001 compared to t = 0. (D) RT-PCR showing that FP inhibits IL-4 and IL-5 mRNA expression in CD3/CD28-costimulated cells.
T16034 25306-25342 Sentence denotes GAPDH was used as a loading control.
T16035 25343-25676 Sentence denotes Lower panels show graphical analysis of results presented as mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to anti-CD3/CD28–stimulated. (E) FP (10 nM) reduces the ability of anti-CD3/CD28-stimulated GATA-3 to associate with the native IL-5 promoter 60 min after stimulation.
T16036 25677-25754 Sentence denotes Data are also shown graphically as mean±SEM of three independent experiments.
T16037 25755-25822 Sentence denotes All data were analysed by ANOVA followed by Newman-Keuls post-test.
T18308 31453-31520 Sentence denotes Fluticasone propionate competes with phospho-GATA-3 for importin-α.
T18309 31521-32365 Sentence denotes (A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p<0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p<0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p<0.05 compared to GATA-3 isolated from unstimulated cells. # p<0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p<0.05, **p<0.01 between groups.
T18310 32366-32494 Sentence denotes All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test.
T18713 33262-33323 Sentence denotes Fluticasone propionate does not affect GATA-3 nuclear export.
T18714 33324-33842 Sentence denotes (A) Western blot analysis showing that the nuclear export inhibitor leptomycin B (2 nM) does not affect the ability of FP (10−8 M) to prevent anti-CD3/CD28–stimulated GATA-3 nuclear localization measured at 60 min. ***p<0.001 compared to unstimulated cells, ### p<0.001 compared to anti-CD3/CD28–stimulated cells. (B) Western blot analysis showing that FP (10−8 M) does not affect whole-cell GATA-3 degradation over 17 h. (C) GFP-tagged GATA-3 is overexpressed and cells stimulated (b–j) or not (a) with anti-CD3/CD28.
T18715 33843-34106 Sentence denotes The effect of treating cells with FP (10−8 M, f–j) after 30 min stimulation with anti-CD3/CD28 is also shown. (D) FP (10−8 M) does not prevent anti-CD3/CD28–stimulated p65 nuclear translocation at 60 min after stimulation. **p<0.01 compared to unstimulated cells.
T18716 34107-34205 Sentence denotes All results are representative of at least four independent experiments and are shown as mean±SEM.
T18717 34206-34267 Sentence denotes Results were analysed by ANOVA followed by Newman-Keuls test.
T19286 34789-34907 Sentence denotes Fluticasone propionate impairs GATA-3 interaction with importin-α and GATA-3 nuclear localization in vivo and ex vivo.
T19287 34908-35102 Sentence denotes (A and B) Co-immunoprecipitation analysis of PBMCs from steroid-naïve asthma patients treated with FP in vitro demonstrated impaired interaction between GATA-3 and importin-α measured at 60 min.
T19288 35103-35464 Sentence denotes Each bar represents the mean±SEM of at least three independent experiments; *** p<0.001 compared with control as determined by ANOVA/Newman-Keuls analysis. (C and D) Co-immunoprecipitation analyses of PBMCs from steroid-naïve asthma patients treated with inhaled FP (500 µg via a spacer) in vivo demonstrated decreased association between GATA-3 and importin-α.
T19289 35465-35635 Sentence denotes The individual values for each treatment are presented graphically. (E) Representative Western blot showing that importin-α expression was unaffected by inhalation of FP.
T19290 35636-35691 Sentence denotes Blot is representative of gels from three participants.
T19726 37976-38052 Sentence denotes Inhaled fluticasone propionate impairs GATA-3 nuclear localization in PBMCs.
T19727 38053-38324 Sentence denotes (A) Representative immunocytochemistry of showing the effect of inhaled FP (500 µg) on GR and GATA-3 nuclear localisation. (B) Nuclear GATA-3 immunoreactivity in PBMCs from seven steroid-naïve asthma patients 2 h following inhaled FP treatment (100 or 500 µg via spacer).
T19728 38325-38840 Sentence denotes The median and interquartile ranges for each treatment are presented as a box-and-whiskers plot (n = 7); * p<0.05 Wilcoxon's rank test compared with placebo. (C) Immunoblotting analyses of PBMCs demonstrated a time-dependent decrease in nuclear expression of GATA-3, and increased cytoplasmic GATA-3 expression after inhalation of FP. (D) Immunoblotting analyses of PBMCs demonstrated a dose-dependent decrease in nuclear expression of GATA-3, and increased cytoplasmic GATA-3 expression 2 h after inhalation of FP.
T19729 38841-38975 Sentence denotes Histone H1 and MEK-1 immunoblotting confirmed equivalent total protein loading for the nuclear and cytoplasmic fractions respectively.
T19730 38976-39337 Sentence denotes Quantification of the densitometry data in (C) and (D) is shown as a box-and-whiskers plot of results from n = 6 participants for which data were available. *p<0.05 compared to control. (E) Western blot analyses of PBMCs demonstrated a time-dependent decrease in dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK after inhalation of FP (500 µg).
T19731 39338-39415 Sentence denotes The results shown in (E) are representative of samples from two participants.
T9685 28251-28266 Sentence denotes Effect on MKP-1
T9686 28267-28468 Sentence denotes Dexamethasone inhibits p38 MAPK function in a cell type–specific manner through the rapid induction of the dual kinase phosphatase MKP-1 (MAPK phosphatase-1), and this effect lasts for up to 24 h [28].
T9687 28469-28688 Sentence denotes FP (10−8 M) treatment of HuT-78 cells activated by anti-CD3/CD28 in vitro significantly decreased p38 MAPK phosphorylation (Figure 3A) and activity measured by phosphorylation of the downstream target ATF-2 (Figure 3B).
T9688 28689-28765 Sentence denotes This effect was detected at 30 min and lasted for at least 14 h (Figure 3B).
T9689 28766-28935 Sentence denotes FP (10−8 M) also significantly reduced GATA-3 serine phosphorylation induced by anti-CD3/CD28 stimulation in both a time- and concentration-dependent manner (Figure 3C).
T9690 28936-29023 Sentence denotes This reduction in GATA-3 phosphorylation was also seen with lower concentrations of FP.
T9691 29024-29187 Sentence denotes We found that FP significantly induced MKP-1 mRNA in both a time- and concentration-dependent manner, reaching a plateau at 10−8 M after 10 min (Figure 3D and 3E).
T9692 29188-29358 Sentence denotes However, the effects of FP on GATA-3 nuclear import, importin-α association and IL-4 mRNA expression are seen at 10,000-fold lower concentrations (10−12 M, see Figure 2).
T16815 26735-26827 Sentence denotes Fluticasone propionate reduces GATA-3 association with importin-α and GATA-3 nuclear import.
T16816 26828-27014 Sentence denotes (A) Western blot analysis demonstrates a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR interaction with importin-α (Imp-α).
T16817 27015-27076 Sentence denotes A positive control for GR association with importin is shown.
T16818 27077-27132 Sentence denotes Quantification of the densitometry data is shown below.
T16819 27133-27438 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. *** p<0.001 compared to control, ### p<0.001. (B) Western blot analysis demonstrated a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR nuclear translocation measured by IP.
T16820 27439-27494 Sentence denotes Quantification of the densitometry data is shown below.
T16821 27495-27781 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ***p<0.001 compared to control. (C) Western blot analysis of HuT-78 cells treated with FP and anti-CD3/CD28 co-stimulation demonstrated a concentration-dependent decrease in GATA-3–importin-α association at 20 min.
T16822 27782-27837 Sentence denotes Quantification of the densitometry data is shown below.
T16823 27838-28103 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) GFP-tagged GATA-3 was overexpressed and cells stimulated (b, c) or not (a) for 30 min with anti-CD3/CD28.
T16824 28104-28181 Sentence denotes The effect of 30 min pretreatment of cells with FP (10−8 M, c) is also shown.
T16825 28182-28249 Sentence denotes All data were analysed by ANOVA followed by Newman-Keuls post-test.
T17603 29403-29572 Sentence denotes Fluticasone propionate–mediated inhibition of p38 MAP kinase phosphorylation and activation is associated with a marked down-regulation of GATA-3 serine phosphorylation.
T17604 29573-30060 Sentence denotes (A) Western blot analysis shows that FP (10−8 M, 30 min) treatment reduced dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK in anti-CD3/CD28–co-stimulated HuT-78 cells. (B) Time course of the effect of FP (10−8 M) on phosphorylation of activated transcription factor 2 (ATF-2), a measure of p38 MAPK activity. (C) FP-induced inhibition of p38 MAPK activity is associated with the decrease of anti-CD3/CD28 co-stimulation–induced serine phosphorylation (P-Ser) of GATA-3.
T17605 30061-30126 Sentence denotes For (A–C), quantification of the densitometry data is also shown.
T17606 30127-30345 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) FP induced MKP-1 mRNA in a concentration-dependent manner.
T17607 30346-30527 Sentence denotes All results are representative of at least three independent experiments and where appropriate expressed as means±SEM, *p<0.05. (E) FP induces MKP-1 mRNA in a time-dependent manner.
T17608 30528-30586 Sentence denotes Results are representative of two independent experiments.
T17609 30587-30665 Sentence denotes All data except (E) were analysed by ANOVA followed by Newman-Keuls post-test.
T135 0-120 Sentence denotes Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease
T136 455-465 Sentence denotes Background
T137 466-658 Sentence denotes GATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases.
T138 659-774 Sentence denotes Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown.
T139 775-912 Sentence denotes We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.
T140 914-934 Sentence denotes Methods and Findings
T141 935-1374 Sentence denotes In a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α.
T142 1375-1579 Sentence denotes In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation.
T143 1580-1653 Sentence denotes These inhibitory effects of fluticasone are rapid, potent, and prolonged.
T144 1654-1802 Sentence denotes We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo.
T145 1804-1815 Sentence denotes Conclusions
T146 1816-1952 Sentence denotes Corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression.
T147 1953-2107 Sentence denotes This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases.
T148 2109-2161 Sentence denotes Please see later in the article for Editors' Summary
T1302 8450-8582 Sentence denotes In order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes.
T1303 8583-8807 Sentence denotes Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12].
T1304 8808-8975 Sentence denotes GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12].
T1305 8976-9134 Sentence denotes Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14].
T1306 9135-9425 Sentence denotes The affinity of the importin-α–NLS interaction is regulated by phosphorylation [15], and we have shown that p38 mitogen-activated protein kinase (MAPK) plays a critical role in phosphorylating GATA-3 to enhance its interaction with importin-α and subsequent transport into the nucleus [12].
T1307 9426-9587 Sentence denotes Corticosteroids are highly effective in the treatment of allergic inflammation, with marked suppression of Th2 cytokines in airways of patients with asthma [16].
T1308 9588-9849 Sentence denotes Corticosteroids mediate their anti-inflammatory effects through binding to glucocorticoid receptors (GRs), which then translocate to the nucleus where they interact with glucocorticoid response elements (GREs) in the promoter regions of steroid-sensitive genes.
T1309 9850-10154 Sentence denotes Alternatively, activated GR interacts with coactivator molecules to suppress the expression of inflammatory genes by inhibiting the action of proinflammatory transcription factors such as nuclear factor-κB (NF-κB) through the recruitment of co-repressor molecules such as histone deacetylase-2 [17],[18].
T1310 10155-10407 Sentence denotes Nuclear localisation and retention of GR is mediated through the nuclear localisation sequences NL1 and NL2 [19], by nuclear retention signals [20], and by control of nuclear export via a chromosomal region maintenance 1 (CRM-1) dependent pathway [21].
T1311 10408-10472 Sentence denotes NL1, which is similar to the SV40 NLS, binds to importin-α [22].
T1312 10473-10644 Sentence denotes NL1 is activated both by glucocorticoid agonists such as dexamethasone and fluticasone propionate (FP) and by glucocorticoid antagonists such as mifepristone (RU486) [23].
T1313 10645-10837 Sentence denotes NL1 can be mutated, and the resulting GR still translocates to the nucleus in response to ligands, but via interaction with importin 7, an event that requires an as-yet unknown component [23].
T1314 10838-10961 Sentence denotes NL2 is poorly defined, residing in the ligand-binding domain, and much less is known about its mechanism of GR import [24].
T1315 10962-11230 Sentence denotes A variety of other factors are also important for the regulation of GR activation and nuclear import including chaperones such as Hsp90 and other immunophilins [24]–[26] and FK506-binding proteins that may be linked to dynein and/or peptidylprolyl isomerase [27],[28].
T1316 11231-11499 Sentence denotes However, the molecular basis for the inhibition of Th2 cytokines by corticosteroids is not well understood, because the genes encoding IL-4, IL-5, and IL-13 do not have any recognisable GRE sequence [29] and are only partly regulated by NF-κB in human cells [30]–[32].
T1317 11500-11670 Sentence denotes Using overexpression and CAT-reporter genes, Lavender and colleagues [33] have shown that GR reduced GATA-3-mediated IL-5 and -13 promoter activity in human CD4+ T cells.
T1318 11671-11897 Sentence denotes The authors postulated that local recruitment of GR may alter the ability of GATA-3 either to bind to its target site, to cause transcriptional up-regulation, or to maintain an environment that is permissive for transcription.
T1319 11898-12158 Sentence denotes We therefore investigated the effects of a synthetic corticosteroid, FP, on GATA-3 phosphorylation and nuclear translocation in a T lymphocyte cell line (HuT-78) and in peripheral blood mononuclear cells activated by anti-CD3 and anti-CD28 antibodies in vitro.
T1320 12159-12325 Sentence denotes We also studied the effects of inhaled fluticasone therapy on GATA-3 subcellular localization in peripheral blood mononuclear cells (PBMCs) from patients with asthma.
T4349 13960-13991 Sentence denotes Cell Culture and PBMC Isolation
T4350 13992-14141 Sentence denotes A human T cell line (HuT-78) was purchased from ECACC European Collection of Cell Culture (Wiltshire, UK) were cultured as previously described [12].
T4351 14142-14295 Sentence denotes PBMCs were isolated by density centrifugation over Ficoll-Hypaque (density, 1.077 g/ml; Amersham Biosciences, Amersham, UK) as previously described [34].
T4352 14296-14452 Sentence denotes Cells were stimulated with anti-CD3/CD28 (1 µg/ml each) for 1 h at 37°C to stimulate Th2 cytokine release in the presence or absence of FP (10−12 to 10−8M).
T4353 14453-14564 Sentence denotes Cytospins were prepared and GATA-3 localization determined by confocal microscopy as previously described [12].
T6774 19780-19800 Sentence denotes GATA-3-GFP Construct
T6775 19801-19950 Sentence denotes The GATA-3 clone (BC003070) complete cDNA was obtained from Invitrogen Life Technologies as a 5′- EcoRI/3′-XhoI insert of GATA-3 in the pOTB7 vector.
T6776 19951-20081 Sentence denotes GATA-3 was excised from pOTB7 using XhoI digestion and pEGFP-C2 (Clontech, Saint-Germain-en-Laye, France) was digested with BamHI.
T6777 20082-20606 Sentence denotes DNA was recovered by phenol extraction and ethanol precipitation, and both the GATA-3 fragment and the pEGFP-C2 vector blunt-ended by incubation with Klenow (Bioline Bio-27029) for 30 min at 37°C. Klenow was inactivated by incubation for 10 min at 75°C. DNA was recovered by phenol extraction and ethanol precipitation, and both the blunt-ended GATA-3 fragment and the GFP vector were subsequently digested with EcoRI before the 5′-EcoRI/3′–blunt end GATA-3 fragment was inserted into the 5′-EcoRI/3′–blunt ended GFP vector.
T6778 20607-20721 Sentence denotes Positive clones were confirmed by digestion and size analysis by 1% agarose gel electrophoresis and by sequencing.
T1 0-57 Sentence denotes Suppression of GATA-3 Nuclear Import and Phosphorylation:
T2 58-159 Sentence denotes A Novel Mechanism of Corticosteroid Action in Allergic Disease Steroid Suppression of GATA-3 Function
T3 162-327 Sentence denotes Peter Barnes and colleagues show that corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that suppress Th2 cytokine expression.
T4 328-444 Sentence denotes This novel mechanism of corticosteroid action may help explain the efficacy of corticosteroids in allergic diseases.
T5 446-454 Sentence denotes Abstract
T6 455-465 Sentence denotes Background
T7 466-658 Sentence denotes GATA-3 plays a critical role in regulating the expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells and therefore is a key mediator of allergic diseases.
T8 659-774 Sentence denotes Corticosteroids are highly effective in suppressing allergic inflammation, but their effects on GATA-3 are unknown.
T9 775-912 Sentence denotes We investigated the effect of the corticosteroid fluticasone propionate on GATA-3 regulation in human T-lymphocytes in vitro and in vivo.
T10 914-934 Sentence denotes Methods and Findings
T11 935-1374 Sentence denotes In a T lymphocyte cell line (HuT-78) and peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 in vitro we demonstrated that fluticasone inhibits nuclear translocation of GATA-3 and expression of Th2 cytokines via a mechanism independent of nuclear factor-κB and is due, in part, to competition between GATA-3 and the ligand-activated glucocorticoid receptor for nuclear transport through the nuclear importer importin-α.
T12 1375-1579 Sentence denotes In addition, fluticasone induces the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), the endogenous inhibitor of p38 MAPK, which is necessary for GATA-3 nuclear translocation.
T13 1580-1653 Sentence denotes These inhibitory effects of fluticasone are rapid, potent, and prolonged.
T14 1654-1802 Sentence denotes We also demonstrated that inhaled fluticasone inhibits GATA-3 nuclear translocation in peripheral blood lymphocytes of patients with asthma in vivo.
T15 1804-1815 Sentence denotes Conclusions
T16 1816-1952 Sentence denotes Corticosteroids have a potent inhibitory effect on GATA-3 via two interacting mechanisms that potently suppress Th2 cytokine expression.
T17 1953-2107 Sentence denotes This novel mechanism of action of corticosteroids may account for the striking clinical efficacy of corticosteroids in the treatment of allergic diseases.
T18 2109-2161 Sentence denotes Please see later in the article for Editors' Summary
T19 2163-2179 Sentence denotes Editors' Summary
T20 2181-2191 Sentence denotes Background
T21 2192-2279 Sentence denotes The immune system protects the human body from viruses, bacteria, parasites, and fungi.
T22 2280-2555 Sentence denotes When one of these foreign invaders enters the body, immune system cells called T lymphocytes recognize specific molecules on the invader's surface and release chemical messengers (cytokines) that recruit and activate other types of immune cell, which then attack the invader.
T23 2556-2787 Sentence denotes Sometimes, however, the immune system responds to a normally harmless material (for example, house-dust mites or grass pollen; scientists call these materials allergens) and triggers an allergic disease such as asthma or hay fever.
T24 2788-2974 Sentence denotes Contact with an allergen activates a type of T lymphocyte called a T helper-2 (Th2) cell that subsequently makes (expresses) three cytokines called interleukin-4 (IL-4), IL-5, and IL-13.
T25 2975-3080 Sentence denotes These cytokines ultimately cause inflammation (swelling) of the part of the body exposed to the allergen.
T26 3081-3213 Sentence denotes Corticosteroids, which suppress the expression of cytokines by Th2 cells, are often used to treat inflammation in allergic diseases.
T27 3214-3455 Sentence denotes Other treatments for these common conditions—about 50 million people in the US have an allergic disease—include minimizing exposure to allergens and diminishing the response of the immune system to allergens by using various immunotherapies.
T28 3457-3481 Sentence denotes Why Was This Study Done?
T29 3482-3626 Sentence denotes Scientists know that corticosteroids reduce allergic inflammation by binding to proteins in immune system cells called glucocorticoid receptors.
T30 3627-3828 Sentence denotes After binding to a corticosteroid, these receptors move into the nucleus of the cell (the part of the cell that contains its genes), where they suppress the expression of certain proinflammatory genes.
T31 3829-3920 Sentence denotes However, it is still not known how corticosteroids inhibit the expression of Th2 cytokines.
T32 3921-4043 Sentence denotes A key regulator of the expression of these cytokines and of allergic inflammation is a transcription factor called GATA-3.
T33 4044-4188 Sentence denotes Transcription factors are proteins that control the expression of other proteins by binding to specific sequences in the genes that encode them.
T34 4189-4413 Sentence denotes In this study, the researchers try to discover more about how corticosteroids reduce allergic inflammation by investigating the effects of the corticosteroid fluticasone on the regulation of GATA-3 activity in T lymphocytes.
T35 4415-4452 Sentence denotes What Did the Researchers Do and Find?
T36 4453-4692 Sentence denotes Transcription factors have to move into the nucleus of cells (so-called nuclear translocation) to control the expression of their target genes, so the researchers first asked whether fluticasone affects the cellular localization of GATA-3.
T37 4693-4856 Sentence denotes Fluticasone treatment of activated T lymphocytes growing in dishes, they report, inhibited the nuclear translocation of GATA-3 and reduced Th2 cytokine expression.
T38 4857-5108 Sentence denotes Other experiments showed that the inhibition of GATA-3 nuclear translocation was partly caused by competition between the glucocorticoid receptor bound to fluticasone and GATA-3 for binding to importin-α, a protein that is required for nuclear import.
T39 5109-5197 Sentence denotes However, fluticasone also prevented the nuclear translocation of GATA-3 in a second way.
T40 5198-5298 Sentence denotes Before GATA-3 can bind to importin-α, phosphate groups have to be added to specific sites in GATA-3.
T41 5299-5522 Sentence denotes This “phosphorylation” requires an enzyme called p38 MAP kinase, and the researchers found that fluticasone treatment of activated T lymphocytes induced the expression of MAP kinase phophatase-1, a p38 MAP kinase inhibitor.
T42 5523-5745 Sentence denotes Finally, when the researchers treated seven patients with mild asthma with inhaled fluticasone, they found that fluticasone also inhibited GATA-3 nuclear translocation in the lymphocytes circulating in the patients' blood.
T43 5747-5775 Sentence denotes What Do These Findings Mean?
T44 5776-5983 Sentence denotes These findings, obtained both in the laboratory and in patients, suggest that corticosteroids inhibit the expression of Th2 cytokines and thus reduce allergic inflammation through two interacting mechanisms.
T45 5984-6263 Sentence denotes They suggest that corticosteroids prevent the nuclear translocation of GATA-3, a key regulator of Th2 cytokine expression, by competing with GATA-3 for binding to importin-α and by preventing the phosphorylation of GATA-3, a modification that allows GATA-3 to bind to importin-α.
T46 6264-6584 Sentence denotes This dual mechanism of corticosteroid action may help to explain why these drugs are so effective in the treatment of allergic diseases, although further experiments are needed to show that the lymphocytes resident at sites of allergic inflammation respond to corticosteroids in the same way as lymphocytes in the blood.
T47 6585-6752 Sentence denotes Finally, these findings suggest that the interaction between phosphorylated GATA-3 and importin-α might be a potential target for new treatments for allergic diseases.
T48 6754-6776 Sentence denotes Additional Information
T49 6777-6896 Sentence denotes Please access these Web sites via the online version of this summary at http://dx.doi.org/10.1371/journal.pmed.1000076.
T50 6897-7228 Sentence denotes The US National Institute of Allergy and Infectious Diseases provides information on allergic diseases and a simple description of the immune system The UK National Health Service Choices service provides information about allergies Links to other information about allergies are available from MedlinePlus (in English and Spanish)
T51 7233-7245 Sentence denotes Introduction
T52 7246-7436 Sentence denotes Inflammation in allergic diseases such as asthma, rhinitis, and atopic dermatitis is mediated via expression of the cytokines interleukin (IL)-4, IL-5, and IL-13 from T helper-2 (Th2) cells.
T53 7437-7566 Sentence denotes IL-4 and IL-13 regulate the expression of IgE from B lymphocytes, whereas IL-5 plays a key role in eosinophilic inflammation [1].
T54 7567-7697 Sentence denotes Th2 cytokines are regulated by the zinc finger transcription factor GATA-3, which is predominantly expressed in Th2 cells [2],[3].
T55 7698-7844 Sentence denotes GATA-3 determines Th2 cell differentiation and selectively activates the promoters of IL-4, IL-5, and IL-13 through chromatin remodelling [4]–[7].
T56 7845-8103 Sentence denotes The key role of GATA-3 in allergic airway inflammation has been demonstrated in mice by the reduced release of Th2 cytokines in animals treated with dominant-negative mutants of GATA-3 and by local application of antisense oligonucleotides to GATA-3 [8],[9].
T57 8104-8308 Sentence denotes Furthermore, conditional knock-out of the Gata3 gene in mice reduces expression of Th2 cytokines in vitro and in vivo [10], and similar results have been reported in isolated murine CD4+ lymphocytes [11].
T58 8309-8449 Sentence denotes Finally, knockdown of GATA-3 expression using siRNA in human T cells results in loss of anti-CD3/CD28-mediated Th2 cytokine expression [12].
T59 8450-8582 Sentence denotes In order for GATA-3 to regulate gene expression, it must translocate from the cytoplasm into the nucleus to access its target genes.
T60 8583-8807 Sentence denotes Enhanced nuclear expression of GATA-3 following T cell receptor activation was first demonstrated in murine T cells [13] and was recently confirmed in human T cells following T cell receptor and co-receptor stimulation [12].
T61 8808-8975 Sentence denotes GATA-3 contains a classical nuclear import signal [14] and is transported into the nucleus by the nuclear import protein importin-α (also known as karyopherin-α) [12].
T62 8976-9134 Sentence denotes Deletion of a region encompassing the GATA-3 nuclear localisation sequence (NLS) region in murine and human cells prevents its nuclear localisation [12],[14].
T63 9135-9425 Sentence denotes The affinity of the importin-α–NLS interaction is regulated by phosphorylation [15], and we have shown that p38 mitogen-activated protein kinase (MAPK) plays a critical role in phosphorylating GATA-3 to enhance its interaction with importin-α and subsequent transport into the nucleus [12].
T64 9426-9587 Sentence denotes Corticosteroids are highly effective in the treatment of allergic inflammation, with marked suppression of Th2 cytokines in airways of patients with asthma [16].
T65 9588-9849 Sentence denotes Corticosteroids mediate their anti-inflammatory effects through binding to glucocorticoid receptors (GRs), which then translocate to the nucleus where they interact with glucocorticoid response elements (GREs) in the promoter regions of steroid-sensitive genes.
T66 9850-10154 Sentence denotes Alternatively, activated GR interacts with coactivator molecules to suppress the expression of inflammatory genes by inhibiting the action of proinflammatory transcription factors such as nuclear factor-κB (NF-κB) through the recruitment of co-repressor molecules such as histone deacetylase-2 [17],[18].
T67 10155-10407 Sentence denotes Nuclear localisation and retention of GR is mediated through the nuclear localisation sequences NL1 and NL2 [19], by nuclear retention signals [20], and by control of nuclear export via a chromosomal region maintenance 1 (CRM-1) dependent pathway [21].
T68 10408-10472 Sentence denotes NL1, which is similar to the SV40 NLS, binds to importin-α [22].
T69 10473-10644 Sentence denotes NL1 is activated both by glucocorticoid agonists such as dexamethasone and fluticasone propionate (FP) and by glucocorticoid antagonists such as mifepristone (RU486) [23].
T70 10645-10837 Sentence denotes NL1 can be mutated, and the resulting GR still translocates to the nucleus in response to ligands, but via interaction with importin 7, an event that requires an as-yet unknown component [23].
T71 10838-10961 Sentence denotes NL2 is poorly defined, residing in the ligand-binding domain, and much less is known about its mechanism of GR import [24].
T72 10962-11230 Sentence denotes A variety of other factors are also important for the regulation of GR activation and nuclear import including chaperones such as Hsp90 and other immunophilins [24]–[26] and FK506-binding proteins that may be linked to dynein and/or peptidylprolyl isomerase [27],[28].
T73 11231-11499 Sentence denotes However, the molecular basis for the inhibition of Th2 cytokines by corticosteroids is not well understood, because the genes encoding IL-4, IL-5, and IL-13 do not have any recognisable GRE sequence [29] and are only partly regulated by NF-κB in human cells [30]–[32].
T74 11500-11670 Sentence denotes Using overexpression and CAT-reporter genes, Lavender and colleagues [33] have shown that GR reduced GATA-3-mediated IL-5 and -13 promoter activity in human CD4+ T cells.
T75 11671-11897 Sentence denotes The authors postulated that local recruitment of GR may alter the ability of GATA-3 either to bind to its target site, to cause transcriptional up-regulation, or to maintain an environment that is permissive for transcription.
T76 11898-12158 Sentence denotes We therefore investigated the effects of a synthetic corticosteroid, FP, on GATA-3 phosphorylation and nuclear translocation in a T lymphocyte cell line (HuT-78) and in peripheral blood mononuclear cells activated by anti-CD3 and anti-CD28 antibodies in vitro.
T77 12159-12325 Sentence denotes We also studied the effects of inhaled fluticasone therapy on GATA-3 subcellular localization in peripheral blood mononuclear cells (PBMCs) from patients with asthma.
T78 12327-12348 Sentence denotes Materials and Methods
T79 12350-12379 Sentence denotes Participants and Study Design
T80 12380-12577 Sentence denotes We studied patients with mild asthma who were not treated with inhaled corticosteroids who had been included in a previously reported double-blind, placebo-controlled, crossover study with FP [34].
T81 12578-12827 Sentence denotes Seven patients with mild asthma entered the study and were randomized to receive a single inhalation of FP (100 and 500 µg) or a matched placebo control via a spacer chamber, and the other treatment was given after a wash-out period of at least 6 d.
T82 12828-12908 Sentence denotes Blood was taken for preparation of PBMCs at 1 and 2 h after drug administration.
T83 12909-13051 Sentence denotes All patients gave informed consent and the study was approved by the Ethics Committee of the Royal Brompton and Harefield Hospitals NHS Trust.
T84 13052-13140 Sentence denotes The clinical study was conducted before the requirement for Clinical Trial Registration.
T85 13142-13165 Sentence denotes Antibodies and Reagents
T86 13166-13296 Sentence denotes The monoclonal antibodies against human CD3, CD28, GR, and importin-α were purchased from BD Biosciences (Oxford, United Kingdom).
T87 13297-13785 Sentence denotes Rabbit antibodies against human GATA-3 (H-48) and GR (E-20, sc-1003) were obtained from Santa Cruz Biotechnology (Santa Cruz, California, United States), polyclonal rabbit antibodies against phospho-p38 MAP kinase and phospho-ATF-2 from Cell Signaling Technology (New England Biolabs, Hertford, UK), monoclonal antibody against phosphoserine (clone 4H4) from Affiniti Research Products (Exeter, UK), and antibodies against rabbit IgG-conjugated TRITC from Dako Cytomation (Cambridge, UK).
T88 13786-13900 Sentence denotes The anti-GR antibody (Clone 41) from BD Transduction Laboratories (Oxford, UK) was used for Western blot analysis.
T89 13901-13958 Sentence denotes All other reagents were purchased from Sigma (Poole, UK).
T90 13960-13991 Sentence denotes Cell Culture and PBMC Isolation
T91 13992-14141 Sentence denotes A human T cell line (HuT-78) was purchased from ECACC European Collection of Cell Culture (Wiltshire, UK) were cultured as previously described [12].
T92 14142-14295 Sentence denotes PBMCs were isolated by density centrifugation over Ficoll-Hypaque (density, 1.077 g/ml; Amersham Biosciences, Amersham, UK) as previously described [34].
T93 14296-14452 Sentence denotes Cells were stimulated with anti-CD3/CD28 (1 µg/ml each) for 1 h at 37°C to stimulate Th2 cytokine release in the presence or absence of FP (10−12 to 10−8M).
T94 14453-14564 Sentence denotes Cytospins were prepared and GATA-3 localization determined by confocal microscopy as previously described [12].
T95 14566-14591 Sentence denotes Reverse Transcription PCR
T96 14592-14669 Sentence denotes Total RNA was extracted using lysis buffer (RNeasy kit; Qiagen, Crawley, UK).
T97 14670-14765 Sentence denotes During RNA purification, genomic DNA was digested with RNase-free DNase (Amersham Biosciences).
T98 14766-14884 Sentence denotes Next, 0.5 µg of total RNA was reversed transcribed using the avian myeloblastosis virus RT (Promega, Southampton, UK).
T99 14885-14955 Sentence denotes For relative quantification, RT-PCR was carried out using cDNA probes.
T100 14956-15013 Sentence denotes Primers for IL-4 were from Sigma-Genosys (Cambridge, UK).
T101 15014-15125 Sentence denotes Sequences of GADPH used are as follows: forward 5′-CCACCCATGGCAAATTCCATGGC, reverse 3′-TCTAGACGGCAGGTCAGGTCCAC.
T102 15127-15193 Sentence denotes Cell Fractionation, Immunoprecipitation, and Western Blot Analysis
T103 15194-15271 Sentence denotes Nuclear and cytoplasmic fractions were prepared as previously described [35].
T104 15272-15441 Sentence denotes Whole cell lysates were prepared in NP-40 lysis buffer (0.5% Nonidet P-40, 20 mM Tris-HCl [pH 7.5], 150 mM NaCl) in the presence of complete protease cocktail inhibitor.
T105 15442-15557 Sentence denotes Lysates were centrifuged at 4°C for 10 min at 12,000 rpm in an Eppendorf microcentrifuge to remove cellular debris.
T106 15558-15809 Sentence denotes Samples were then immunoprecipitated with either 10 µl of antibody against GATA-3 or importin-α using A/G agarose slurry in the presence of protease inhibitor using the Catch and Release methodology (Upstate Biotechnology, Lake Placid, New York, USA).
T107 15810-15946 Sentence denotes Western blot analysis was performed using anti-GATA-3, anti-importin-α, anti-GR, anti-p-p38 MAP kinase, anti-p-ATF-2, and anti-p-serine.
T108 15947-16052 Sentence denotes Immunoreactive proteins were detected using an enhanced chemiluminescence ECL kit (Amersham Biosciences).
T109 16054-16083 Sentence denotes Chromatin Immunoprecipitation
T110 16084-16332 Sentence denotes Chromatin immunoprecipitation (IP) was performed as previously described [12] in HuT-78 T-cells with 2 µg of anti-GATA-3 (Santa Cruz Biotechnology), or isotypic immunoglobulin G as a non-specific control (Santa Cruz Biotechnology) overnight at 4°C.
T111 16333-16467 Sentence denotes Promoter sequences were detected with PCR primers for the IL-5 promoter (−445 to +4): forward 5′-TTAATCTAGCCACAGTCATAG-3′ and reverse:
T112 16468-16496 Sentence denotes 5′-TCATGGCTCTGAAACGTTCTG-3′.
T113 16497-16677 Sentence denotes PCR was performed using a Hybaid Omnigene thermal cycler (Hybaid, Ashford, UK) with cycling parameters of 72°C for 10 min, 35 cycles at 94°C for 45 s, 52°C for 45 s, 72°C for 45 s.
T114 16679-16750 Sentence denotes GR-GATA-3 In Vitro Competition Assay for Importin-α (Far-Western ELISA)
T115 16751-16926 Sentence denotes Immunoprecipitated importin-α (anti-importin-α, Santa Cruz Biotechnology) from HuT-78 cells was separated by SDS-PAGE and purified from the excised gel by electroelution [36].
T116 16927-17109 Sentence denotes Similarly, GATA-3 was isolated from nonstimulated HuT-78 cells or cells stimulated for 30 min with anti-CD3/CD28 and GR was isolated from FP (10−8 M, 30 min) stimulated HuT-78 cells.
T117 17110-17172 Sentence denotes These proteins were subsequently refolded in glycine solution.
T118 17173-17292 Sentence denotes 100 µl of importin-α solution (100 ng/ml in TBS) was added to 96-well plates coated with goat anti-importin-α antibody.
T119 17293-17421 Sentence denotes After 1 h incubation, GATA-3 (100 ng/ml in TBS) from stimulated or unstimulated cells were added to the importin-α-coated wells.
T120 17422-17513 Sentence denotes GR (10 or 100 ng/ml in TBS) from stimulated or unstimulated cells were added to some wells.
T121 17514-17739 Sentence denotes After a further 1 h incubation, the plate was washed and incubated with primary antibodies (a mixture of rabbit anti-GATA-3 and mouse anti-GR, Santa Cruz Biotechnology) for 1.5 h, and then incubated with secondary antibodies.
T122 17740-17930 Sentence denotes FITC swine anti-rabbit IgG (Dako, Cambridge, UK) was used for the detection of GATA-3, and rhodamine donkey anti-mouse IgG (Novus, Littleton, Colorado, USA) was used for the detection of GR.
T123 17931-18031 Sentence denotes FITC and rhodamine levels were measured with a fluorescent micro-plate reader (Bioline, London, UK).
T124 18033-18049 Sentence denotes NF-κB Activation
T125 18050-18182 Sentence denotes NF-κB binding activity in nuclear extracts was determined using an ELISA-based kit (Trans-AM p65, Active Motif, Rixensart, Belgium).
T126 18183-18293 Sentence denotes In brief, 5 µg of nuclear extracts were incubated with a plate coated with an NF-κB consensus oligonucleotide.
T127 18294-18353 Sentence denotes Plates were washed before addition of an anti-p65 antibody.
T128 18354-18458 Sentence denotes Antibody binding was detected with a secondary HRP-conjugated antibody and developed with TMB substrate.
T129 18459-18512 Sentence denotes The intensity of the reaction was measured at 450 nm.
T130 18514-18541 Sentence denotes Immunofluorescence Staining
T131 18542-18613 Sentence denotes Immunofluorescence staining was performed as previously described [34].
T132 18614-18686 Sentence denotes All staining was performed at room temperature and under humidification.
T133 18687-18786 Sentence denotes Cells were collected and cytospins prepared in a cytocentrifuge (Shandon II, Shandon, Runcorn, UK).
T134 18787-18971 Sentence denotes Cells were permeabilized, blocked, and then incubated with GR (1∶50 E-20 Santa Cruz Biotechnology) or anti-GATA-3 (H-48; Santa Cruz Biotechnology) antibody for 1 h at room temperature.
T135 18972-19127 Sentence denotes After three washes in phosphate-buffered saline (PBS), cells were incubated with tetrarhodamine isothiocyanate–conjugated goat anti-rabbit antibody (Dako).
T136 19128-19304 Sentence denotes Cytospins were counterstained with 4′,6-diamidino-2-phenylindole dihydrochloride (DAPI), a fluorescent blue nuclear indole chromatin stain, and mounted in PBS:glycerol (50∶50).
T137 19305-19508 Sentence denotes The immunopositive signal was characterised using laser scanning confocal microscopy on a Leica TCS NT/SP interactive laser cytometer equipped with confocal optics (Leica Microsystems, Wetzlar, Germany).
T138 19509-19659 Sentence denotes To determine the specificity of the antibodies, rabbit serum immunoglobulin (Dako) and secondary antibodies without the primary were used as controls.
T139 19660-19778 Sentence denotes Positively stained nuclei and total cells were counted (500) on each slide with the observer blinded to the treatment.
T140 19780-19800 Sentence denotes GATA-3-GFP Construct
T141 19801-19950 Sentence denotes The GATA-3 clone (BC003070) complete cDNA was obtained from Invitrogen Life Technologies as a 5′- EcoRI/3′-XhoI insert of GATA-3 in the pOTB7 vector.
T142 19951-20081 Sentence denotes GATA-3 was excised from pOTB7 using XhoI digestion and pEGFP-C2 (Clontech, Saint-Germain-en-Laye, France) was digested with BamHI.
T143 20082-20278 Sentence denotes DNA was recovered by phenol extraction and ethanol precipitation, and both the GATA-3 fragment and the pEGFP-C2 vector blunt-ended by incubation with Klenow (Bioline Bio-27029) for 30 min at 37°C.
T144 20279-20335 Sentence denotes Klenow was inactivated by incubation for 10 min at 75°C.
T145 20336-20606 Sentence denotes DNA was recovered by phenol extraction and ethanol precipitation, and both the blunt-ended GATA-3 fragment and the GFP vector were subsequently digested with EcoRI before the 5′-EcoRI/3′–blunt end GATA-3 fragment was inserted into the 5′-EcoRI/3′–blunt ended GFP vector.
T146 20607-20721 Sentence denotes Positive clones were confirmed by digestion and size analysis by 1% agarose gel electrophoresis and by sequencing.
T147 20723-20735 Sentence denotes Transfection
T148 20736-21007 Sentence denotes HuT-78 cells were transfected with either EP8 or GFP vector only DNA using solution R, programme V-001 at a ratio of 3×106 cells/4 µg DNA for 7–8 h in complete medium (10% bovine serum in RPMI1640+15 L-glutamine) according to the general Amaxa protocol for nucleofection.
T149 21008-21171 Sentence denotes The medium was subsequently changed to 1% RPMI for 24 h before transfected cells were added to anti-CD3/CD28 treated wells and live cell videomicroscopy performed.
T150 21173-21194 Sentence denotes Time-Lapse Microscopy
T151 21195-21463 Sentence denotes HuT-78 cells expressing GATA-3-GFP were maintained at 37°C in growth medium in a closed FCS2 perfusion chamber (Bioptechs, Butler, Pennsylvania, USA) combined with an objective heater (Bioptechs) on the stage a Zeiss Axiovert 200 microscope (Thornwood, New York, USA).
T152 21464-21729 Sentence denotes Observations were made by 40×1.0 NA oil-immersion objective lens, and fluorescence and phase contrast images were gathered using a Hamamatsu ORCA-ER charged coupled device camera (Bridgewater, New Jersey, USA) driven by Openlab software (Improvision, Coventry, UK).
T153 21730-21784 Sentence denotes Photographs were taken at 0, 30, 60, 120, and 240 min.
T154 21786-21808 Sentence denotes Densitometric Analysis
T155 21809-21938 Sentence denotes Densitometry of ECL immunoblots was performed using Gelworks ID intermediate software (Ultraviolet Products, Cambridgeshire, UK).
T156 21939-22019 Sentence denotes Briefly, immunoblots were scanned and gates were drawn tightly around each band.
T157 22020-22099 Sentence denotes Background values from each lane were subtracted to normalize each measurement.
T158 22100-22154 Sentence denotes The bands were quantified using the Gelworks software.
T159 22155-22326 Sentence denotes All Western blots were exposed to film for varying lengths of time, and only films generating subsaturating levels of intensity were selected for densitometric evaluation.
T160 22328-22348 Sentence denotes Statistical Analysis
T161 22349-22563 Sentence denotes Data from three or more independent experiments are presented as the mean±standard error of the mean (SEM), except where stated and were compared using GraphPad Prism 4 (GraphPad Software, http://www.graphpad.com).
T162 22564-22787 Sentence denotes Results were analysed using one-way ANOVA with Newman-Keuls post test except for the data from the in vivo inhaled FP study, which was analysed by Friedman's test with subsequent Wilcoxson matched pair signed rank sum test.
T163 22788-22853 Sentence denotes Data from this analysis are presented as a box-and-whiskers plot.
T164 22854-23003 Sentence denotes Friedman's test was used as three matched measures were obtained using placebo, 100 µg, and 500 µg of inhaled FP, which had variable baseline levels.
T165 23004-23161 Sentence denotes We did not assume a Gaussian distribution of the data due to the limited numbers of participants analysed (seven).The null hypothesis was rejected at p<0.05.
T166 23163-23170 Sentence denotes Results
T167 23172-23247 Sentence denotes The Effect of Corticosteroids on GATA-3 Nuclear Translocation and IL-4 mRNA
T168 23248-23356 Sentence denotes Corticosteroids are effective in inhibiting GATA-3-regulated IL-4 gene expression in vitro and in vivo [32].
T169 23357-23464 Sentence denotes We therefore investigated whether corticosteroids affect anti-CD3/CD28–stimulated nuclear import of GATA-3.
T170 23465-23616 Sentence denotes Stimulation of cells with anti-CD3/CD28 resulted in a rapid cytoplasmic/nuclear GATA-3 translocation (Figure 1A), confirming our previous results [12].
T171 23617-23746 Sentence denotes We also confirmed a clear separation of nuclear and cytosolic fractions as indicated by histone H1 and MEK-1 markers (Figure 1B).
T172 23747-23958 Sentence denotes The potent topical corticosteroid FP caused sustained loss of nuclear GATA-3 expression and cytoplasmic retention of GATA-3 at concentrations ranging from 10−12 to 10−8 M, which cover the therapeutic range [37].
T173 23959-24274 Sentence denotes This effect was concentration- and time-dependent, with a peak effect of 11.6-fold at 30 min at a concentration of 10−8 M (Figure 1C) and was associated with marked reductions in anti-CD3/CD28–stimulated IL-4 and IL-5 mRNA expression (Figure 1D) and a loss of GATA-3 binding to the native IL-5 promoter (Figure 1E).
T174 24275-24421 Sentence denotes 10.1371/journal.pmed.1000076.g001 Figure 1 Fluticasone propionate down-regulates Th2 cytokine gene expression and inhibits GATA-3 nuclear import.
T175 24422-24921 Sentence denotes (A) Anti-CD3/CD28 treatment of HuT-78 cells results in translocation of GATA-3 from the cytoplasm to the nucleus within 30 min. (B) Histone H1 and MEK-1 were used to confirm distinct separation of cytoplasmic and nuclear extracts in three separate experiments. (C) Western blot analysis of FP-treated HuT-78 cells demonstrated impaired nuclear localization of GATA-3 induced by anti-CD3/CD28 co-stimulation in a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent manner.
T176 24922-24984 Sentence denotes Cells were pretreated with FP for 30 min prior to stimulation.
T177 24985-25081 Sentence denotes MEK1 and histone H1 were used to demonstrate equal cytoplasmic and nuclear loading respectively.
T178 25082-25305 Sentence denotes Results are presented graphically below as mean±SEM of at least three independent experiments. *** p<0.001 compared to t = 0. (D) RT-PCR showing that FP inhibits IL-4 and IL-5 mRNA expression in CD3/CD28-costimulated cells.
T179 25306-25342 Sentence denotes GAPDH was used as a loading control.
T180 25343-25676 Sentence denotes Lower panels show graphical analysis of results presented as mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to anti-CD3/CD28–stimulated. (E) FP (10 nM) reduces the ability of anti-CD3/CD28-stimulated GATA-3 to associate with the native IL-5 promoter 60 min after stimulation.
T181 25677-25754 Sentence denotes Data are also shown graphically as mean±SEM of three independent experiments.
T182 25755-25822 Sentence denotes All data were analysed by ANOVA followed by Newman-Keuls post-test.
T183 25824-25879 Sentence denotes Ligand-Activated GR Competes with GATA-3 for Importin-α
T184 25880-26034 Sentence denotes We confirmed and extended previous data [20] to show that ligand-activated GR as well as GATA-3 uses importin-α for its nuclear import (Figure 2A and 2B).
T185 26035-26161 Sentence denotes This interaction between GR and importin-α was significant at concentrations as low as 10−12 M and was maximal with 10−8 M FP.
T186 26162-26274 Sentence denotes Subsequent GR nuclear translocation was rapid and sustained at significant levels for at least 14 h (Figure 2B).
T187 26275-26476 Sentence denotes Using IP-Western blotting we showed that FP at 10−12–10−8 M decreased the association between GATA-3 and importin-α induced by anti-CD3/CD28 stimulation in a concentration-dependent manner (Figure 2C).
T188 26477-26690 Sentence denotes In addition, using GFP-labelled GATA-3 and confocal microscopy we demonstrated that GATA-3 nuclear import following anti-CD3/CD28 stimulation for 30 min was attenuated by pretreatment with FP (10−8 M) (Figure 2D).
T189 26691-26827 Sentence denotes 10.1371/journal.pmed.1000076.g002 Figure 2 Fluticasone propionate reduces GATA-3 association with importin-α and GATA-3 nuclear import.
T190 26828-27014 Sentence denotes (A) Western blot analysis demonstrates a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR interaction with importin-α (Imp-α).
T191 27015-27076 Sentence denotes A positive control for GR association with importin is shown.
T192 27077-27132 Sentence denotes Quantification of the densitometry data is shown below.
T193 27133-27438 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. *** p<0.001 compared to control, ### p<0.001. (B) Western blot analysis demonstrated a time- (at 10−8 M FP) and concentration- (at 60 min after stimulation) dependent induction of FP-activated GR nuclear translocation measured by IP.
T194 27439-27494 Sentence denotes Quantification of the densitometry data is shown below.
T195 27495-27781 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ***p<0.001 compared to control. (C) Western blot analysis of HuT-78 cells treated with FP and anti-CD3/CD28 co-stimulation demonstrated a concentration-dependent decrease in GATA-3–importin-α association at 20 min.
T196 27782-27837 Sentence denotes Quantification of the densitometry data is shown below.
T197 27838-28103 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) GFP-tagged GATA-3 was overexpressed and cells stimulated (b, c) or not (a) for 30 min with anti-CD3/CD28.
T198 28104-28181 Sentence denotes The effect of 30 min pretreatment of cells with FP (10−8 M, c) is also shown.
T199 28182-28249 Sentence denotes All data were analysed by ANOVA followed by Newman-Keuls post-test.
T200 28251-28266 Sentence denotes Effect on MKP-1
T201 28267-28468 Sentence denotes Dexamethasone inhibits p38 MAPK function in a cell type–specific manner through the rapid induction of the dual kinase phosphatase MKP-1 (MAPK phosphatase-1), and this effect lasts for up to 24 h [28].
T202 28469-28688 Sentence denotes FP (10−8 M) treatment of HuT-78 cells activated by anti-CD3/CD28 in vitro significantly decreased p38 MAPK phosphorylation (Figure 3A) and activity measured by phosphorylation of the downstream target ATF-2 (Figure 3B).
T203 28689-28765 Sentence denotes This effect was detected at 30 min and lasted for at least 14 h (Figure 3B).
T204 28766-28935 Sentence denotes FP (10−8 M) also significantly reduced GATA-3 serine phosphorylation induced by anti-CD3/CD28 stimulation in both a time- and concentration-dependent manner (Figure 3C).
T205 28936-29023 Sentence denotes This reduction in GATA-3 phosphorylation was also seen with lower concentrations of FP.
T206 29024-29187 Sentence denotes We found that FP significantly induced MKP-1 mRNA in both a time- and concentration-dependent manner, reaching a plateau at 10−8 M after 10 min (Figure 3D and 3E).
T207 29188-29358 Sentence denotes However, the effects of FP on GATA-3 nuclear import, importin-α association and IL-4 mRNA expression are seen at 10,000-fold lower concentrations (10−12 M, see Figure 2).
T208 29359-29572 Sentence denotes 10.1371/journal.pmed.1000076.g003 Figure 3 Fluticasone propionate–mediated inhibition of p38 MAP kinase phosphorylation and activation is associated with a marked down-regulation of GATA-3 serine phosphorylation.
T209 29573-30060 Sentence denotes (A) Western blot analysis shows that FP (10−8 M, 30 min) treatment reduced dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK in anti-CD3/CD28–co-stimulated HuT-78 cells. (B) Time course of the effect of FP (10−8 M) on phosphorylation of activated transcription factor 2 (ATF-2), a measure of p38 MAPK activity. (C) FP-induced inhibition of p38 MAPK activity is associated with the decrease of anti-CD3/CD28 co-stimulation–induced serine phosphorylation (P-Ser) of GATA-3.
T210 30061-30126 Sentence denotes For (A–C), quantification of the densitometry data is also shown.
T211 30127-30345 Sentence denotes Each bar represents mean±SEM of at least three independent experiments. ### p<0.001 compared to control, ***p<0.001 compared to αCD3/CD28-stimulated cells. (D) FP induced MKP-1 mRNA in a concentration-dependent manner.
T212 30346-30527 Sentence denotes All results are representative of at least three independent experiments and where appropriate expressed as means±SEM, *p<0.05. (E) FP induces MKP-1 mRNA in a time-dependent manner.
T213 30528-30586 Sentence denotes Results are representative of two independent experiments.
T214 30587-30665 Sentence denotes All data except (E) were analysed by ANOVA followed by Newman-Keuls post-test.
T215 30668-30927 Sentence denotes Using an in vitro competition assay (Figure 4A) utilizing purified activated GATA-3, importin-α, and activated GR, we demonstrated that activated GR significantly increased GR-importin-α association in the presence and absence of activated GATA-3 (Figure 4B).
T216 30928-31030 Sentence denotes This effect is not mutual, since activated GATA-3 did not block GR–importin-α association (Figure 4C).
T217 31031-31271 Sentence denotes These data also suggest that both activated GR and phospho-GATA-3 can directly associate with importin-α (Figure 4D) and that activated GR attenuates the phospho-GATA-3/importin-α interaction in a concentration-dependent manner (Figure 4E).
T218 31272-31408 Sentence denotes Together, this suggests that ligand-activated GR may compete with phospho-GATA-3 for importin-α and thereby limit GATA-3 nuclear import.
T219 31409-31520 Sentence denotes 10.1371/journal.pmed.1000076.g004 Figure 4 Fluticasone propionate competes with phospho-GATA-3 for importin-α.
T220 31521-32365 Sentence denotes (A) schematic representation of the in vitro binding competition assay. (B) GR isolated from FP (10−8 M) stimulated cells enhances GR–importin-α binding in the presence (•) and absence (▪) of activated GATA-3. * p<0.05 compared to no activated GR. (C) GATA-3 isolated from anti-CD3/CD28–stimulated cells does not attenuate GR–importin-α association. *p<0.05 compared to control. (D) Activated GR blocks the ability of purified phospho-GATA-3 isolated from anti-CD3/CD28–stimulated cells interacting with immobilised importin-α in an in vitro binding assay. *p<0.05 compared to GATA-3 isolated from unstimulated cells. # p<0.05 compared to stimulated GATA-3-importin binding. (E) The effect of activated (•) versus unstimulated (○) GR on attenuation of GATA-3–importin-α association was concentration-dependent. *p<0.05, **p<0.01 between groups.
T221 32366-32494 Sentence denotes All results are expressed as mean±SEM of three independent experiments and analysed by ANOVA followed by Newman-Keuls post-test.
T222 32497-32617 Sentence denotes Other possible interpretations of our results could include an effect of FP on GATA-3 nuclear export and/or degradation.
T223 32618-32745 Sentence denotes Leptomycin B, which inhibits nuclear export, did not affect the ability of FP to block GATA-3 nuclear localization (Figure 5A).
T224 32746-32865 Sentence denotes Additionally, FP had no effect on whole cell GATA-3 expression during the time course of these experiments (Figure 5B).
T225 32866-33052 Sentence denotes Nor did addition of FP subsequent to anti-CD3/CD28 nuclear translocation affect GATA-3 nuclear residency (Figure 5C), suggesting that activated GR does not enhance GATA-3 nuclear export.
T226 33053-33217 Sentence denotes Finally, the effect of FP on GATA-3 nuclear import was not nonspecific, since FP (10−8 M) had no effect on p65 nuclear translocation measured at 60 min (Figure 5D).
T227 33218-33323 Sentence denotes 10.1371/journal.pmed.1000076.g005 Figure 5 Fluticasone propionate does not affect GATA-3 nuclear export.
T228 33324-33842 Sentence denotes (A) Western blot analysis showing that the nuclear export inhibitor leptomycin B (2 nM) does not affect the ability of FP (10−8 M) to prevent anti-CD3/CD28–stimulated GATA-3 nuclear localization measured at 60 min. ***p<0.001 compared to unstimulated cells, ### p<0.001 compared to anti-CD3/CD28–stimulated cells. (B) Western blot analysis showing that FP (10−8 M) does not affect whole-cell GATA-3 degradation over 17 h. (C) GFP-tagged GATA-3 is overexpressed and cells stimulated (b–j) or not (a) with anti-CD3/CD28.
T229 33843-34106 Sentence denotes The effect of treating cells with FP (10−8 M, f–j) after 30 min stimulation with anti-CD3/CD28 is also shown. (D) FP (10−8 M) does not prevent anti-CD3/CD28–stimulated p65 nuclear translocation at 60 min after stimulation. **p<0.01 compared to unstimulated cells.
T230 34107-34205 Sentence denotes All results are representative of at least four independent experiments and are shown as mean±SEM.
T231 34206-34267 Sentence denotes Results were analysed by ANOVA followed by Newman-Keuls test.
T232 34269-34385 Sentence denotes The Inhibitory Effect of Corticosteroids on GATA-3 Nuclear Localization in Primary T Lymphocytes Ex Vivo and In Vivo
T233 34386-34744 Sentence denotes Treatment with FP ex vivo demonstrated a concentration-dependent decrease in the direct interaction between phospho-GATA-3 and importin-α in PBMCs from patients with asthma (Figure 6A and 6B), which was significantly inhibited at 10−12 M FP (p<0.001, ANOVA and Newman-Keuls test) and completely attenuated by 10−8 M FP (p<0.001, ANOVA and Newman-Keuls test).
T234 34745-34907 Sentence denotes 10.1371/journal.pmed.1000076.g006 Figure 6 Fluticasone propionate impairs GATA-3 interaction with importin-α and GATA-3 nuclear localization in vivo and ex vivo.
T235 34908-35102 Sentence denotes (A and B) Co-immunoprecipitation analysis of PBMCs from steroid-naïve asthma patients treated with FP in vitro demonstrated impaired interaction between GATA-3 and importin-α measured at 60 min.
T236 35103-35464 Sentence denotes Each bar represents the mean±SEM of at least three independent experiments; *** p<0.001 compared with control as determined by ANOVA/Newman-Keuls analysis. (C and D) Co-immunoprecipitation analyses of PBMCs from steroid-naïve asthma patients treated with inhaled FP (500 µg via a spacer) in vivo demonstrated decreased association between GATA-3 and importin-α.
T237 35465-35635 Sentence denotes The individual values for each treatment are presented graphically. (E) Representative Western blot showing that importin-α expression was unaffected by inhalation of FP.
T238 35636-35691 Sentence denotes Blot is representative of gels from three participants.
T239 35694-35872 Sentence denotes Our previous T cell line studies indicated that 10−12 M FP suppresses IL-4 and -5 gene expression and attenuated the interaction of GATA-3 with importin-α (see Figures 1D and 2).
T240 35873-35994 Sentence denotes This concentration is close to peak plasma levels obtained from asthmatic patients treated with inhaled FP (500 µg) [27].
T241 35995-36151 Sentence denotes Inhaled FP (500 µg) treatment of seven steroid-naive asthma patients significantly reduced GATA-3–importin-α interaction in vivo in a time-dependent manner.
T242 36152-36314 Sentence denotes This produced a >90% decrease in GATA-3–importin-α association at 2 h (median [95% CI], 13,494 [6,828–17,829] versus 879 [597–1,165]; p<0.05 Friedman's analysis).
T243 36315-36447 Sentence denotes However, this did not reach significance using Wilcoxon's post-test analysis (W = 6.00) probably due to low numbers of participants.
T244 36448-36545 Sentence denotes Similar results were observed when GATA-3–importin-α association was measured (Figure 6C and 6D).
T245 36546-36594 Sentence denotes The lower dose of FP (100 µg) was not effective.
T246 36595-36801 Sentence denotes The attenuated interaction of GATA-3 did not result from the defective recycling of importin-α, as a significant decrease in the abundance of importin-α in the cytoplasmic pool was not detected (Figure 6E).
T247 36802-36914 Sentence denotes We further examined whether inhaled FP could affect cellular localization of GATA-3 in peripheral blood T cells.
T248 36915-37265 Sentence denotes Treatment with inhaled FP (500 µg) for 2 h significantly increased GR nuclear translocation (Figure 7A) and concomitantly decreased the number of nuclear GATA-3 immunoreactive peripheral blood T cells (37%±4.2% versus 58.2%±4.95%, p = 0.016, W = 28.0, Wilcoxon's rank test) compared with placebo as measured by immunocytochemistry (Figure 7A and 7B).
T249 37266-37397 Sentence denotes This was confirmed by Western blotting, which also indicated that this effect was both time- and dose-dependent (Figure 7C and 7D).
T250 37398-37795 Sentence denotes Thus, inhaled FP (500 µg) induced significant loss in nuclear GATA-3 at 2 h (median [95% CI], 0.40 [0.27–0.53] versus 0.14 [0.11–0.19], p<0.05, W = 21.00, Wilcoxon's rank test) (Figure 7C) and cytoplasmic GATA-3 levels were enhanced by inhaled FP in a dose-dependent manner (median [95% CI], 0.0032 [0.0026–0.0039] versus 0.658 [0.592–0.720], p<0.05, W = −21.00, Wilcoxon's rank test) (Figure 7D).
T251 37796-37931 Sentence denotes In addition, FP (500 µg) inhibited p38 MAPK phosphorylation in primary T cells in vivo at 2 h in samples from two patients (Figure 7E).
T252 37932-38052 Sentence denotes 10.1371/journal.pmed.1000076.g007 Figure 7 Inhaled fluticasone propionate impairs GATA-3 nuclear localization in PBMCs.
T253 38053-38324 Sentence denotes (A) Representative immunocytochemistry of showing the effect of inhaled FP (500 µg) on GR and GATA-3 nuclear localisation. (B) Nuclear GATA-3 immunoreactivity in PBMCs from seven steroid-naïve asthma patients 2 h following inhaled FP treatment (100 or 500 µg via spacer).
T254 38325-38840 Sentence denotes The median and interquartile ranges for each treatment are presented as a box-and-whiskers plot (n = 7); * p<0.05 Wilcoxon's rank test compared with placebo. (C) Immunoblotting analyses of PBMCs demonstrated a time-dependent decrease in nuclear expression of GATA-3, and increased cytoplasmic GATA-3 expression after inhalation of FP. (D) Immunoblotting analyses of PBMCs demonstrated a dose-dependent decrease in nuclear expression of GATA-3, and increased cytoplasmic GATA-3 expression 2 h after inhalation of FP.
T255 38841-38975 Sentence denotes Histone H1 and MEK-1 immunoblotting confirmed equivalent total protein loading for the nuclear and cytoplasmic fractions respectively.
T256 38976-39337 Sentence denotes Quantification of the densitometry data in (C) and (D) is shown as a box-and-whiskers plot of results from n = 6 participants for which data were available. *p<0.05 compared to control. (E) Western blot analyses of PBMCs demonstrated a time-dependent decrease in dual phosphorylation (threonine-180 and tyrosine-182) of p38 MAPK after inhalation of FP (500 µg).
T257 39338-39415 Sentence denotes The results shown in (E) are representative of samples from two participants.
T258 39418-39572 Sentence denotes Taken together, our data suggest that inhaled FP reduces nuclear localization of GATA-3 in vivo by acutely inhibiting phospho-GATA-3–importin association.
T259 39573-39759 Sentence denotes This effect may be direct, through competition for importin-α or associated molecules, or secondary to an effect on p38 MAPK-mediated GATA-3 phosphorylation via rapid induction of MKP-1.
T260 39760-39907 Sentence denotes The combination of these two interacting effects can result in complete suppression of GATA-3 nuclear import and thus Th2 cytokine gene expression.
T261 39909-39919 Sentence denotes Discussion
T262 39920-40132 Sentence denotes Here we have demonstrated, to our knowledge for the first time, that corticosteroids may inhibit GATA-3 function and therefore the transcription of Th2 genes via two distinct but interacting molecular mechanisms.
T263 40133-40312 Sentence denotes Firstly, corticosteroid-activated GR appears to compete with activated GATA-3 for nuclear import via importin-α, which is required for the nuclear transport of both GATA-3 and GR.
T264 40313-40630 Sentence denotes Secondly, corticosteroids at higher concentrations increase the expression of MKP-1, a potent inhibitor of p38 MAPK activity and thereby prevent T cell receptor/co-receptor activation of p38 MAPK to prevent the phosphorylation of GATA-3 that is necessary for interaction with importin-α and subsequent nuclear import.
T265 40631-40820 Sentence denotes We have previously shown that translocation of GATA-3 from the cytoplasm to the nucleus involves the nuclear transporter protein importin-α, which interacts with phosphorylated GATA-3 [12].
T266 40821-41052 Sentence denotes We have also previously reported that GATA-3 knockdown using siRNA results in suppression of anti-CD3/CD28–stimulated IL-4/IL-5 mRNA induction, thus implicating an essential role for GATA-3 in the transcription of these genes [12].
T267 41053-41154 Sentence denotes We now confirm, in human T cells, that GR also uses the same nuclear import mechanism as GATA-3 [22].
T268 41155-41268 Sentence denotes We therefore propose that there is competition between ligand-activated GR and phospho-GATA-3 for nuclear import.
T269 41269-41542 Sentence denotes Furthermore, we have shown that there is preferential binding of importin-α to activated GR over phospho-GATA-3, so that corticosteroids would preferentially reduce GATA-3 entry and thus rapidly switch off Th2 gene transcription without any need for any intermediate steps.
T270 41543-41702 Sentence denotes Furthermore, there was some degree of specificity for GATA-3, as nuclear translocation of the p65 subunit of NF-κB was not affected by corticosteroid exposure.
T271 41703-41897 Sentence denotes We tested some alternative explanations for this effect of FP on GATA-3 nuclear exclusion and failed to show that FP either enhances GATA-3 nuclear export directly or induces GATA-3 degradation.
T272 41898-42104 Sentence denotes The evidence from the in vitro competition assays does, however, suggest that purified activated GR can clearly attenuate purified phospho-GATA-3–importin-α association and that the converse does not occur.
T273 42105-42187 Sentence denotes Furthermore, we have shown that only phospho-GATA-3 can associate with importin-α.
T274 42188-42337 Sentence denotes This mechanism is sensitive to very low concentrations of corticosteroid and would be rapid in onset as no changes in protein synthesis are required.
T275 42338-42537 Sentence denotes This acute mechanism may also contribute to the reduction in GATA-3 nuclear import and may play a major role at low corticosteroid concentrations and/or at early time points prior to MKP-1 induction.
T276 42538-42674 Sentence denotes Corticosteroids can modulate p38 MAPK activity through the induction of MKP-1, a potent endogenous inhibitor of MAPK function [38],[39].
T277 42675-42795 Sentence denotes We report here a rapid induction of MKP-1 mRNA following stimulation of cells with relatively high concentrations of FP.
T278 42796-42989 Sentence denotes We hypothesize that this rapid induction of MKP-1 can reduce GATA-3 nuclear import by attenuating p38 MAPK activity and subsequent GATA-3 phosphorylation, thus preventing nuclear translocation.
T279 42990-43256 Sentence denotes The location of the serine residue(s) of GATA-3 that are phosphorylated by p38 MAPK are currently unknown, but a bioinformatics search (Motif Scanner, http://scansite.mit.edu/motifscan_seq.phtml) indicates at least three potential p38 MAPK-sensitive serine residues.
T280 43257-43439 Sentence denotes As predicted from these in vitro data, impairment of GATA-3 nuclear import by FP may, at least in part, underlie the efficacy of corticosteroids in suppressing allergic inflammation.
T281 43440-43740 Sentence denotes Although we did not assess the acute inhibitory effect of FP on the expression of IL-4 mRNA in vivo, a single inhalation of FP (500 µg) may have comparable effects, as it provides plasma levels within a relevant range of concentrations used to suppress IL-4 transcription in our in vitro system [37].
T282 43741-43872 Sentence denotes A lower dose of inhaled FP (100 µg) was not effective, but plasma concentrations may be below those required for GATA-3 inhibition.
T283 43873-44053 Sentence denotes However, it is likely that the higher concentrations of FP in the airways after inhaled administration would be effective in inhibiting GATA-3 in airway T cells of asthma patients.
T284 44054-44276 Sentence denotes The study of PBMCs from asthma patients treated with inhaled corticosteroid therapy clearly demonstrates that these molecular mechanisms are likely to also occur in patients at therapeutic doses of inhaled corticosteroids.
T285 44277-44452 Sentence denotes In addition, previous studies have shown that corticosteroids can suppress IL-4 and IL-5 release from peripheral blood cells of asthma patients in vitro and in vivo [40]–[42].
T286 44453-44896 Sentence denotes In summary, our data provide evidence for a novel action of corticosteroids: suppression of allergic inflammation through a rapid inhibitory effect on GATA-3 nuclear translocation by preferential binding to the shared nuclear import protein importin-α and by a second mechanism involving increased synthesis of MKP-1, which inhibits p38 MAPK, thus preventing the phosphorylation of GATA-3 that is necessary for nuclear translocation of GATA-3.
T287 44897-45035 Sentence denotes These two mechanisms are likely to be synergistic, accounting for the rapid and potent effect of corticosteroids on allergic inflammation.
T288 45036-45235 Sentence denotes This is exemplified by the rapid inhibitory effect of topical corticosteroids on nasal Th2 cytokine release after allergen provocation in individuals with seasonal allergic rhinitis (hay fever) [43].
T289 45236-45398 Sentence denotes Prevention of phospho-GATA-3 interaction with importin-α may provide a new approach for the development of novel therapies for the treatment of allergic diseases.

ICD10

Id Subject Object Predicate Lexical cue
T780 1787-1793 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3297 7288-7294 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T3298 9575-9581 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T3299 12318-12324 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T3300 7288-7294 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3954 12410-12416 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T3955 12603-12609 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T3956 12410-12416 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3957 12603-12609 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T19580 34978-34984 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T19581 35329-35335 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T19582 34978-34984 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T19583 35329-35335 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T769 1787-1793 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T12585 34552-34558 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T12586 36048-36054 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T12587 34552-34558 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T12588 36048-36054 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T15281 44037-44043 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T15282 44078-44084 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T15283 44405-44411 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T15284 44037-44043 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T15285 44078-44084 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T15286 44405-44411 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T15287 45200-45217 http://purl.bioontology.org/ontology/ICD10/J30.4 denotes allergic rhinitis
T15288 45223-45228 http://purl.bioontology.org/ontology/ICD10/R50.9 denotes fever
T20248 38246-38252 http://purl.bioontology.org/ontology/ICD10/J45.9 denotes asthma
T20249 38246-38252 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3301 9575-9581 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3302 12318-12324 http://purl.bioontology.org/ontology/ICD10/J45 denotes asthma
T3303 7310-7327 http://purl.bioontology.org/ontology/ICD10/L20 denotes atopic dermatitis
T3304 7310-7327 http://purl.bioontology.org/ontology/ICD10/L20.9 denotes atopic dermatitis
T3305 7317-7327 http://purl.bioontology.org/ontology/ICD10/L30.9 denotes dermatitis

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T873 0-11 Negative_regulation denotes Suppression
T874 0-11 Negative_regulation denotes Suppression
T875 15-21 Protein denotes GATA-3
T876 22-29 Entity denotes Nuclear
T877 30-36 Localization denotes Import
T878 41-56 Phosphorylation denotes Phosphorylation
T879 466-472 Protein denotes GATA-3
T880 498-508 Regulation denotes regulating
T881 498-508 Regulation denotes regulating
T882 498-508 Regulation denotes regulating
T883 513-523 Gene_expression denotes expression
T884 513-523 Gene_expression denotes expression
T885 513-523 Gene_expression denotes expression
T886 541-559 Protein denotes interleukin (IL)-4
T887 561-565 Protein denotes IL-5
T888 571-576 Protein denotes IL-13
T889 755-761 Protein denotes GATA-3
T890 795-801 Regulation denotes effect
T891 850-856 Protein denotes GATA-3
T892 857-867 Regulation denotes regulation
T893 1090-1098 Negative_regulation denotes inhibits
T894 1099-1106 Entity denotes nuclear
T895 1107-1120 Localization denotes translocation
T896 1124-1130 Protein denotes GATA-3
T897 1236-1247 Negative_regulation denotes competition
T898 1236-1247 Negative_regulation denotes competition
T899 1256-1262 Protein denotes GATA-3
T900 1278-1287 Positive_regulation denotes activated
T901 1288-1311 Protein denotes glucocorticoid receptor
T902 1316-1323 Entity denotes nuclear
T903 1324-1333 Localization denotes transport
T904 1324-1333 Localization denotes transport
T905 1400-1407 Positive_regulation denotes induces
T906 1412-1422 Gene_expression denotes expression
T907 1426-1479 Protein denotes mitogen-activated protein kinase (MAPK) phosphatase-1
T908 1481-1486 Protein denotes MKP-1
T909 1536-1545 Positive_regulation denotes necessary
T910 1550-1556 Protein denotes GATA-3
T911 1557-1564 Entity denotes nuclear
T912 1565-1578 Localization denotes translocation
T913 1700-1708 Negative_regulation denotes inhibits
T914 1709-1715 Protein denotes GATA-3
T915 1716-1723 Entity denotes nuclear
T916 1724-1737 Localization denotes translocation
T917 1846-1863 Negative_regulation denotes inhibitory effect
T918 1867-1873 Protein denotes GATA-3
T3556 7372-7390 Protein denotes interleukin (IL)-4
T3557 7392-7396 Protein denotes IL-5
T3558 7402-7407 Protein denotes IL-13
T3559 7437-7441 Protein denotes IL-4
T3560 7446-7451 Protein denotes IL-13
T3561 7511-7515 Protein denotes IL-5
T3562 7635-7641 Protein denotes GATA-3
T3563 7666-7675 Gene_expression denotes expressed
T3564 7698-7704 Protein denotes GATA-3
T3565 7757-7766 Positive_regulation denotes activates
T3566 7757-7766 Positive_regulation denotes activates
T3567 7757-7766 Positive_regulation denotes activates
T3568 7771-7780 Entity denotes promoters
T3569 7784-7788 Protein denotes IL-4
T3570 7790-7794 Protein denotes IL-5
T3571 7800-7805 Protein denotes IL-13
T3572 7861-7867 Protein denotes GATA-3
T3573 8023-8029 Protein denotes GATA-3
T3574 8088-8094 Protein denotes GATA-3
T3575 8146-8151 Protein denotes Gata3
T3576 8286-8289 Protein denotes CD4
T3577 8318-8327 Negative_regulation denotes knockdown
T3578 8331-8337 Protein denotes GATA-3
T3579 8338-8348 Gene_expression denotes expression
T3580 8463-8469 Protein denotes GATA-3
T3581 8507-8518 Localization denotes translocate
T3582 8547-8554 Entity denotes nucleus
T3583 8558-8564 Binding denotes access
T3584 8569-8575 Binding denotes target
T3585 8592-8599 Entity denotes nuclear
T3586 8600-8610 Localization denotes expression
T3587 8614-8620 Protein denotes GATA-3
T3588 8621-8630 Positive_regulation denotes following
T3589 8748-8757 Positive_regulation denotes following
T3590 8808-8814 Protein denotes GATA-3
T3591 8870-8881 Localization denotes transported
T3592 8891-8898 Entity denotes nucleus
T3593 9014-9020 Protein denotes GATA-3
T3594 9304-9308 Regulation denotes role
T3595 9312-9327 Phosphorylation denotes phosphorylating
T3596 9328-9334 Protein denotes GATA-3
T3597 9338-9345 Positive_regulation denotes enhance
T3598 9350-9361 Binding denotes interaction
T3599 9652-9659 Binding denotes binding
T3600 9663-9687 Protein denotes glucocorticoid receptors
T3601 9689-9692 Protein denotes GRs
T3602 9706-9717 Localization denotes translocate
T3603 9725-9732 Entity denotes nucleus
T3604 9744-9752 Binding denotes interact
T3605 9865-9874 Positive_regulation denotes activated
T3606 9875-9877 Protein denotes GR
T3607 9878-9887 Binding denotes interacts
T3608 10076-10087 Binding denotes recruitment
T3609 10122-10143 Protein denotes histone deacetylase-2
T3610 10155-10162 Entity denotes Nuclear
T3611 10163-10175 Localization denotes localisation
T3612 10180-10189 Localization denotes retention
T3613 10193-10195 Protein denotes GR
T3614 10199-10207 Positive_regulation denotes mediated
T3615 10199-10207 Positive_regulation denotes mediated
T3616 10311-10318 Regulation denotes control
T3617 10322-10329 Entity denotes nuclear
T3618 10330-10336 Localization denotes export
T3619 10343-10375 Protein denotes chromosomal region maintenance 1
T3620 10377-10382 Protein denotes CRM-1
T3621 10384-10393 Regulation denotes dependent
T3622 10408-10411 Entity denotes NL1
T3623 10447-10452 Binding denotes binds
T3624 10673-10682 Regulation denotes resulting
T3625 10683-10685 Protein denotes GR
T3626 10692-10704 Localization denotes translocates
T3627 10712-10719 Entity denotes nucleus
T3628 10720-10734 Positive_regulation denotes in response to
T3629 10752-10763 Binding denotes interaction
T3630 10769-10779 Protein denotes importin 7
T3631 10795-10803 Positive_regulation denotes requires
T3632 10946-10948 Protein denotes GR
T3633 10949-10955 Localization denotes import
T3634 10998-11007 Regulation denotes important
T3635 11016-11026 Regulation denotes regulation
T3636 11030-11032 Protein denotes GR
T3637 11033-11043 Positive_regulation denotes activation
T3638 11366-11370 Protein denotes IL-4
T3639 11372-11376 Protein denotes IL-5
T3640 11382-11387 Protein denotes IL-13
T3641 11455-11464 Regulation denotes regulated
T3642 11455-11464 Regulation denotes regulated
T3643 11455-11464 Regulation denotes regulated
T3644 11525-11528 Protein denotes CAT
T3645 11590-11592 Protein denotes GR
T3646 11593-11600 Negative_regulation denotes reduced
T3647 11593-11600 Negative_regulation denotes reduced
T3648 11601-11607 Protein denotes GATA-3
T3649 11608-11616 Positive_regulation denotes mediated
T3650 11608-11616 Positive_regulation denotes mediated
T3651 11617-11621 Protein denotes IL-5
T3652 11626-11629 Protein denotes -13
T3653 11639-11647 Gene_expression denotes activity
T3654 11639-11647 Gene_expression denotes activity
T3655 11657-11660 Protein denotes CD4
T3656 11705-11716 Localization denotes recruitment
T3657 11720-11722 Protein denotes GR
T3658 11727-11732 Regulation denotes alter true
T3659 11748-11754 Protein denotes GATA-3
T3660 11765-11769 Binding denotes bind
T3661 11928-11935 Regulation denotes effects true
T3662 11928-11935 Regulation denotes effects true
T3663 11974-11980 Protein denotes GATA-3
T3664 11981-11996 Phosphorylation denotes phosphorylation
T3665 12001-12008 Entity denotes nuclear
T3666 12009-12022 Localization denotes translocation
T3667 12179-12186 Regulation denotes effects
T3668 12221-12227 Protein denotes GATA-3
T3669 12240-12252 Localization denotes localization
T6048 16679-16681 Protein denotes GR
T6049 16682-16688 Protein denotes GATA-3
T6050 16938-16944 Protein denotes GATA-3
T6051 17044-17046 Protein denotes GR
T6052 17315-17321 Protein denotes GATA-3
T6053 17422-17424 Protein denotes GR
T6054 17819-17825 Protein denotes GATA-3
T6055 17927-17929 Protein denotes GR
T6731 18846-18848 Protein denotes GR
T8795 23176-23182 Regulation denotes Effect
T8796 23176-23182 Regulation denotes Effect
T8797 23205-23211 Protein denotes GATA-3
T8798 23212-23219 Entity denotes Nuclear
T8799 23220-23233 Localization denotes Translocation
T8800 23238-23242 Protein denotes IL-4
T8801 23268-23277 Regulation denotes effective
T8802 23281-23291 Negative_regulation denotes inhibiting
T8803 23292-23298 Protein denotes GATA-3
T8804 23299-23308 Regulation denotes regulated
T8805 23309-23313 Protein denotes IL-4
T8806 23319-23329 Gene_expression denotes expression
T8807 23407-23413 Regulation denotes affect true
T8808 23428-23438 Positive_regulation denotes stimulated
T8809 23439-23446 Entity denotes nuclear
T8810 23447-23453 Localization denotes import
T8811 23457-23463 Protein denotes GATA-3
T8812 23505-23513 Positive_regulation denotes resulted
T8813 23537-23544 Entity denotes nuclear
T8814 23545-23551 Protein denotes GATA-3
T8815 23552-23565 Localization denotes translocation
T8816 23720-23725 Protein denotes MEK-1
T8817 23784-23790 Positive_regulation denotes caused
T8818 23784-23790 Positive_regulation denotes caused
T8819 23801-23805 Negative_regulation denotes loss
T8820 23809-23816 Entity denotes nuclear
T8821 23817-23823 Protein denotes GATA-3
T8822 23824-23834 Localization denotes expression
T8823 23839-23850 Entity denotes cytoplasmic
T8824 23851-23860 Localization denotes retention
T8825 23864-23870 Protein denotes GATA-3
T8826 23959-23970 Regulation denotes This effect
T8827 23959-23970 Regulation denotes This effect
T8828 23959-23970 Regulation denotes This effect
T8829 23999-24008 Regulation denotes dependent
T8830 23999-24008 Regulation denotes dependent
T8831 23999-24008 Regulation denotes dependent
T8832 24101-24111 Regulation denotes associated
T8833 24101-24111 Regulation denotes associated
T8834 24101-24111 Regulation denotes associated
T8835 24124-24134 Negative_regulation denotes reductions
T8836 24124-24134 Negative_regulation denotes reductions
T8837 24152-24162 Positive_regulation denotes stimulated
T8838 24152-24162 Positive_regulation denotes stimulated
T8839 24163-24167 Protein denotes IL-4
T8840 24172-24176 Protein denotes IL-5
T8841 24177-24192 Transcription denotes mRNA expression
T8842 24177-24192 Transcription denotes mRNA expression
T8843 24211-24215 Negative_regulation denotes loss
T8844 24219-24225 Protein denotes GATA-3
T8845 24226-24233 Binding denotes binding
T8846 24248-24252 Protein denotes IL-5
T8847 24253-24261 Entity denotes promoter
T9360 25841-25843 Protein denotes GR
T9361 25858-25864 Protein denotes GATA-3
T9362 25865-25868 Binding denotes for
T9363 25945-25954 Positive_regulation denotes activated
T9364 25955-25957 Protein denotes GR
T9365 25969-25975 Protein denotes GATA-3
T9366 25976-25980 Positive_regulation denotes uses
T9367 25976-25980 Positive_regulation denotes uses
T9368 26000-26007 Entity denotes nuclear
T9369 26008-26014 Localization denotes import
T9370 26008-26014 Localization denotes import
T9371 26060-26062 Protein denotes GR
T9372 26173-26175 Protein denotes GR
T9373 26176-26183 Entity denotes nuclear
T9374 26184-26197 Localization denotes translocation
T9375 26335-26344 Negative_regulation denotes decreased
T9376 26349-26360 Binding denotes association
T9377 26369-26375 Protein denotes GATA-3
T9378 26391-26398 Positive_regulation denotes induced
T9379 26447-26456 Regulation denotes dependent
T9380 26496-26515 Protein denotes GFP-labelled GATA-3
T9381 26561-26567 Protein denotes GATA-3
T9382 26568-26575 Entity denotes nuclear
T9383 26576-26582 Localization denotes import
T9384 26583-26592 Positive_regulation denotes following
T9385 26634-26644 Negative_regulation denotes attenuated
T10991 28261-28266 Protein denotes MKP-1
T10992 28357-28366 Gene_expression denotes induction
T10993 28398-28403 Protein denotes MKP-1
T10994 28405-28423 Protein denotes MAPK phosphatase-1
T10995 28557-28566 Negative_regulation denotes decreased
T10996 28629-28644 Phosphorylation denotes phosphorylation
T10997 28663-28669 Binding denotes target
T10998 28670-28675 Protein denotes ATF-2
T10999 28797-28804 Negative_regulation denotes reduced
T11000 28805-28811 Protein denotes GATA-3
T11001 28812-28818 Entity denotes serine
T11002 28819-28834 Phosphorylation denotes phosphorylation
T11003 28835-28842 Positive_regulation denotes induced
T11004 28906-28915 Regulation denotes dependent
T11005 28936-28950 Negative_regulation denotes This reduction
T11006 28954-28960 Protein denotes GATA-3
T11007 28961-28976 Phosphorylation denotes phosphorylation
T11008 29055-29062 Positive_regulation denotes induced
T11009 29063-29068 Protein denotes MKP-1
T11010 29069-29073 Transcription denotes mRNA
T11011 29108-29117 Regulation denotes dependent
T11012 29201-29208 Regulation denotes effects
T11013 29201-29208 Regulation denotes effects
T11014 29201-29208 Regulation denotes effects
T11015 29218-29224 Protein denotes GATA-3
T11016 29225-29232 Entity denotes nuclear
T11017 29233-29239 Localization denotes import
T11018 29252-29263 Binding denotes association
T11019 29268-29272 Protein denotes IL-4
T11020 29273-29288 Transcription denotes mRNA expression
T11021 30686-30697 Negative_regulation denotes competition
T11022 30686-30697 Negative_regulation denotes competition
T11023 30735-30744 Positive_regulation denotes activated
T11024 30745-30751 Protein denotes GATA-3
T11025 30769-30778 Positive_regulation denotes activated
T11026 30779-30781 Protein denotes GR
T11027 30804-30813 Positive_regulation denotes activated
T11028 30814-30816 Protein denotes GR
T11029 30831-30840 Positive_regulation denotes increased
T11030 30841-30843 Protein denotes GR
T11031 30855-30866 Binding denotes association
T11032 30867-30897 Regulation denotes in the presence and absence of true
T11033 30898-30907 Positive_regulation denotes activated
T11034 30908-30914 Protein denotes GATA-3
T11035 30961-30970 Positive_regulation denotes activated
T11036 30971-30977 Protein denotes GATA-3
T11037 30986-30991 Negative_regulation denotes block true
T11038 30992-30994 Protein denotes GR
T11039 31006-31017 Binding denotes association
T11040 31065-31074 Positive_regulation denotes activated
T11041 31075-31077 Protein denotes GR
T11042 31090-31096 Protein denotes GATA-3
T11043 31110-31119 Binding denotes associate
T11044 31110-31119 Binding denotes associate
T11045 31157-31166 Positive_regulation denotes activated
T11046 31167-31169 Protein denotes GR
T11047 31170-31180 Negative_regulation denotes attenuates
T11048 31185-31192 Phosphorylation denotes phospho
T11049 31193-31199 Protein denotes GATA-3
T11050 31211-31222 Binding denotes interaction
T11051 31242-31251 Regulation denotes dependent
T11052 31308-31317 Positive_regulation denotes activated
T11053 31318-31320 Protein denotes GR
T11054 31325-31332 Negative_regulation denotes compete true
T11055 31346-31352 Protein denotes GATA-3
T11056 31353-31356 Binding denotes for
T11057 31380-31385 Negative_regulation denotes limit
T11058 31386-31392 Protein denotes GATA-3
T11059 31393-31400 Entity denotes nuclear
T11060 31401-31407 Localization denotes import
T11061 32560-32566 Regulation denotes effect
T11062 32560-32566 Regulation denotes effect
T11063 32576-32582 Protein denotes GATA-3
T11064 32583-32590 Entity denotes nuclear
T11065 32591-32597 Localization denotes export
T11066 32605-32616 Protein_catabolism denotes degradation
T11067 32671-32677 Regulation denotes affect true
T11068 32699-32704 Negative_regulation denotes block
T11069 32705-32711 Protein denotes GATA-3
T11070 32712-32719 Entity denotes nuclear
T11071 32720-32732 Localization denotes localization
T11072 32770-32776 Regulation denotes effect true
T11073 32791-32797 Protein denotes GATA-3
T11074 32798-32808 Gene_expression denotes expression
T11075 32939-32945 Regulation denotes affect true
T11076 32946-32952 Protein denotes GATA-3
T11077 32953-32960 Entity denotes nuclear
T11078 32961-32970 Localization denotes residency
T11079 33000-33009 Positive_regulation denotes activated
T11080 33010-33012 Protein denotes GR
T11081 33022-33029 Positive_regulation denotes enhance true
T11082 33030-33036 Protein denotes GATA-3
T11083 33037-33044 Entity denotes nuclear
T11084 33045-33051 Localization denotes export
T11085 33066-33072 Regulation denotes effect
T11086 33082-33088 Protein denotes GATA-3
T11087 33089-33096 Entity denotes nuclear
T11088 33097-33103 Localization denotes import
T11089 33150-33156 Regulation denotes effect true
T11090 33160-33163 Protein denotes p65
T11091 33164-33171 Entity denotes nuclear
T11092 33172-33185 Localization denotes translocation
T12731 34273-34283 Negative_regulation denotes Inhibitory
T12732 34313-34319 Protein denotes GATA-3
T12733 34320-34327 Entity denotes Nuclear
T12734 34328-34340 Localization denotes Localization
T12735 34441-34450 Regulation denotes dependent
T12736 34451-34459 Negative_regulation denotes decrease
T12737 34474-34485 Binding denotes interaction
T12738 34494-34501 Phosphorylation denotes phospho
T12739 34502-34508 Protein denotes GATA-3
T12740 34603-34612 Negative_regulation denotes inhibited
T12741 34681-34691 Negative_regulation denotes attenuated
T12742 35753-35763 Negative_regulation denotes suppresses
T12743 35753-35763 Negative_regulation denotes suppresses
T12744 35764-35768 Protein denotes IL-4
T12745 35773-35775 Protein denotes -5
T12746 35781-35791 Gene_expression denotes expression
T12747 35781-35791 Gene_expression denotes expression
T12748 35796-35806 Negative_regulation denotes attenuated
T12749 35811-35822 Binding denotes interaction
T12750 35826-35832 Protein denotes GATA-3
T12751 36078-36085 Negative_regulation denotes reduced
T12752 36086-36092 Protein denotes GATA-3
T12753 36104-36115 Binding denotes interaction
T12754 36134-36143 Regulation denotes dependent
T12755 36157-36165 Regulation denotes produced
T12756 36173-36181 Negative_regulation denotes decrease
T12757 36185-36191 Protein denotes GATA-3
T12758 36203-36214 Binding denotes association
T12759 36483-36489 Protein denotes GATA-3
T12760 36501-36512 Binding denotes association
T12761 36599-36609 Negative_regulation denotes attenuated
T12762 36610-36621 Binding denotes interaction
T12763 36625-36631 Protein denotes GATA-3
T12764 36847-36853 Regulation denotes affect true
T12765 36863-36875 Localization denotes localization
T12766 36879-36885 Protein denotes GATA-3
T12767 36972-36981 Positive_regulation denotes increased
T12768 36982-36984 Protein denotes GR
T12769 36985-36992 Entity denotes nuclear
T12770 36993-37006 Localization denotes translocation
T12771 37069-37075 Protein denotes GATA-3
T12772 37424-37431 Positive_regulation denotes induced
T12773 37444-37448 Localization denotes loss true
T12774 37452-37459 Entity denotes nuclear
T12775 37460-37466 Protein denotes GATA-3
T12776 37591-37602 Entity denotes cytoplasmic
T12777 37603-37609 Protein denotes GATA-3
T12778 37610-37616 Localization denotes levels
T12779 37622-37630 Positive_regulation denotes enhanced
T12780 37655-37664 Regulation denotes dependent
T12781 39467-39474 Negative_regulation denotes reduces
T12782 39475-39482 Entity denotes nuclear
T12783 39483-39495 Localization denotes localization
T12784 39499-39505 Protein denotes GATA-3
T12785 39525-39535 Negative_regulation denotes inhibiting
T12786 39544-39550 Protein denotes GATA-3
T12787 39560-39571 Binding denotes association
T12788 39698-39706 Positive_regulation denotes mediated
T12789 39707-39713 Protein denotes GATA-3
T12790 39714-39729 Phosphorylation denotes phosphorylation
T12791 39740-39749 Gene_expression denotes induction
T12792 39753-39758 Protein denotes MKP-1
T12793 39801-39808 Regulation denotes effects
T12794 39832-39843 Negative_regulation denotes suppression
T12795 39847-39853 Protein denotes GATA-3
T12796 39854-39861 Entity denotes nuclear
T12797 39862-39868 Localization denotes import
T15783 40017-40023 Protein denotes GATA-3
T15784 40157-40166 Positive_regulation denotes activated
T15785 40167-40169 Protein denotes GR
T15786 40181-40188 Negative_regulation denotes compete
T15787 40194-40203 Positive_regulation denotes activated
T15788 40204-40210 Protein denotes GATA-3
T15789 40215-40222 Entity denotes nuclear
T15790 40223-40229 Localization denotes import
T15791 40230-40233 Regulation denotes via
T15792 40255-40263 Regulation denotes required
T15793 40255-40263 Regulation denotes required
T15794 40272-40279 Entity denotes nuclear
T15795 40280-40289 Localization denotes transport
T15796 40280-40289 Localization denotes transport
T15797 40298-40304 Protein denotes GATA-3
T15798 40309-40311 Protein denotes GR
T15799 40364-40372 Positive_regulation denotes increase
T15800 40377-40387 Gene_expression denotes expression
T15801 40391-40396 Protein denotes MKP-1
T15802 40512-40519 Negative_regulation denotes prevent
T15803 40524-40539 Phosphorylation denotes phosphorylation
T15804 40543-40549 Protein denotes GATA-3
T15805 40558-40567 Positive_regulation denotes necessary
T15806 40558-40567 Positive_regulation denotes necessary
T15807 40572-40583 Binding denotes interaction
T15808 40604-40614 Positive_regulation denotes subsequent
T15809 40615-40622 Entity denotes nuclear
T15810 40623-40629 Localization denotes import
T15811 40661-40674 Localization denotes translocation
T15812 40678-40684 Protein denotes GATA-3
T15813 40711-40718 Entity denotes nucleus
T15814 40719-40727 Regulation denotes involves
T15815 40778-40787 Binding denotes interacts
T15816 40793-40807 Phosphorylation denotes phosphorylated
T15817 40808-40814 Protein denotes GATA-3
T15818 40859-40865 Protein denotes GATA-3
T15819 40866-40875 Gene_expression denotes knockdown true
T15820 40899-40910 Negative_regulation denotes suppression
T15821 40899-40910 Negative_regulation denotes suppression
T15822 40928-40938 Positive_regulation denotes stimulated
T15823 40928-40938 Positive_regulation denotes stimulated
T15824 40939-40943 Protein denotes IL-4
T15825 40944-40948 Protein denotes IL-5
T15826 40954-40963 Transcription denotes induction
T15827 40954-40963 Transcription denotes induction
T15828 40995-40999 Regulation denotes role
T15829 40995-40999 Regulation denotes role
T15830 41004-41010 Protein denotes GATA-3
T15831 41018-41031 Transcription denotes transcription
T15832 41018-41031 Transcription denotes transcription
T15833 41092-41094 Protein denotes GR
T15834 41114-41121 Entity denotes nuclear
T15835 41122-41128 Localization denotes import
T15836 41142-41148 Protein denotes GATA-3
T15837 41190-41201 Negative_regulation denotes competition true
T15838 41227-41229 Protein denotes GR
T15839 41234-41241 Phosphorylation denotes phospho
T15840 41242-41248 Protein denotes GATA-3
T15841 41253-41260 Entity denotes nuclear
T15842 41261-41267 Localization denotes import
T15843 41323-41330 Binding denotes binding
T15844 41323-41330 Binding denotes binding
T15845 41348-41357 Positive_regulation denotes activated
T15846 41358-41360 Protein denotes GR
T15847 41366-41373 Phosphorylation denotes phospho
T15848 41374-41380 Protein denotes GATA-3
T15849 41427-41433 Negative_regulation denotes reduce true
T15850 41434-41440 Protein denotes GATA-3
T15851 41441-41446 Localization denotes entry
T15852 41597-41603 Protein denotes GATA-3
T15853 41608-41615 Entity denotes nuclear
T15854 41616-41629 Localization denotes translocation
T15855 41637-41640 Protein denotes p65
T15856 41666-41674 Regulation denotes affected true
T15857 41747-41758 Negative_regulation denotes this effect
T15858 41768-41774 Protein denotes GATA-3
T15859 41775-41782 Entity denotes nuclear
T15860 41783-41792 Localization denotes exclusion
T15861 41827-41835 Positive_regulation denotes enhances true
T15862 41836-41842 Protein denotes GATA-3
T15863 41843-41850 Entity denotes nuclear
T15864 41851-41857 Localization denotes export
T15865 41870-41877 Positive_regulation denotes induces true
T15866 41878-41884 Protein denotes GATA-3
T15867 41885-41896 Protein_catabolism denotes degradation
T15868 41985-41994 Positive_regulation denotes activated
T15869 41995-41997 Protein denotes GR
T15870 42010-42019 Negative_regulation denotes attenuate
T15871 42029-42036 Phosphorylation denotes phospho
T15872 42037-42043 Protein denotes GATA-3
T15873 42055-42066 Binding denotes association
T15874 42142-42149 Phosphorylation denotes phospho
T15875 42150-42156 Protein denotes GATA-3
T15876 42161-42170 Binding denotes associate
T15877 42368-42378 Positive_regulation denotes contribute true
T15878 42386-42395 Negative_regulation denotes reduction
T15879 42399-42405 Protein denotes GATA-3
T15880 42406-42413 Entity denotes nuclear
T15881 42414-42420 Localization denotes import
T15882 42442-42446 Regulation denotes role true
T15883 42521-42526 Protein denotes MKP-1
T15884 42527-42536 Gene_expression denotes induction
T15885 42597-42606 Positive_regulation denotes induction
T15886 42610-42615 Protein denotes MKP-1
T15887 42698-42707 Gene_expression denotes induction
T15888 42711-42716 Protein denotes MKP-1
T15889 42722-42731 Positive_regulation denotes following
T15890 42827-42836 Gene_expression denotes induction
T15891 42840-42845 Protein denotes MKP-1
T15892 42850-42856 Negative_regulation denotes reduce
T15893 42857-42863 Protein denotes GATA-3
T15894 42864-42871 Entity denotes nuclear
T15895 42872-42878 Localization denotes import
T15896 42882-42893 Negative_regulation denotes attenuating
T15897 42916-42926 Regulation denotes subsequent
T15898 42927-42933 Protein denotes GATA-3
T15899 42934-42949 Phosphorylation denotes phosphorylation
T15900 42956-42966 Negative_regulation denotes preventing true
T15901 42967-42974 Entity denotes nuclear
T15902 42975-42988 Localization denotes translocation
T15903 43010-43024 Entity denotes serine residue
T15904 43031-43037 Protein denotes GATA-3
T15905 43047-43061 Phosphorylation denotes phosphorylated
T15906 43296-43306 Negative_regulation denotes impairment
T15907 43310-43316 Protein denotes GATA-3
T15908 43317-43324 Entity denotes nuclear
T15909 43325-43331 Localization denotes import
T15910 43477-43494 Negative_regulation denotes inhibitory effect true true
T15911 43508-43518 Transcription denotes expression
T15912 43522-43526 Protein denotes IL-4
T15913 43684-43692 Negative_regulation denotes suppress
T15914 43693-43697 Protein denotes IL-4
T15915 43698-43711 Transcription denotes transcription
T15916 43854-43860 Protein denotes GATA-3
T15917 43861-43871 Negative_regulation denotes inhibition
T15918 43998-44008 Negative_regulation denotes inhibiting
T15919 44009-44015 Protein denotes GATA-3
T15920 44343-44351 Negative_regulation denotes suppress
T15921 44343-44351 Negative_regulation denotes suppress
T15922 44352-44356 Protein denotes IL-4
T15923 44361-44365 Protein denotes IL-5
T15924 44366-44373 Localization denotes release
T15925 44366-44373 Localization denotes release
T15926 44583-44600 Negative_regulation denotes inhibitory effect
T15927 44583-44600 Negative_regulation denotes inhibitory effect
T15928 44604-44610 Protein denotes GATA-3
T15929 44611-44618 Entity denotes nuclear
T15930 44619-44632 Localization denotes translocation
T15931 44649-44656 Binding denotes binding
T15932 44741-44750 Positive_regulation denotes increased
T15933 44751-44760 Gene_expression denotes synthesis
T15934 44764-44769 Protein denotes MKP-1
T15935 44801-44811 Negative_regulation denotes preventing
T15936 44816-44831 Phosphorylation denotes phosphorylation
T15937 44835-44841 Protein denotes GATA-3
T15938 44850-44859 Positive_regulation denotes necessary
T15939 44864-44871 Entity denotes nuclear
T15940 44872-44885 Localization denotes translocation
T15941 44889-44895 Protein denotes GATA-3
T15942 45236-45246 Negative_regulation denotes Prevention
T15943 45250-45257 Phosphorylation denotes phospho
T15944 45258-45264 Protein denotes GATA-3
T15945 45265-45276 Binding denotes interaction
T16674 24390-24398 Negative_regulation denotes inhibits
T16675 24399-24405 Protein denotes GATA-3
T16676 24406-24413 Entity denotes nuclear
T16677 24414-24420 Localization denotes import
T16678 24477-24490 Localization denotes translocation
T16679 24494-24500 Protein denotes GATA-3
T16680 24527-24534 Entity denotes nucleus
T16681 24569-24574 Protein denotes MEK-1
T16682 24758-24765 Entity denotes nuclear
T16683 24766-24778 Localization denotes localization
T16684 24782-24788 Protein denotes GATA-3
T16685 24789-24796 Positive_regulation denotes induced
T16686 24985-24989 Protein denotes MEK1
T16687 25235-25243 Negative_regulation denotes inhibits
T16688 25235-25243 Negative_regulation denotes inhibits
T16689 25244-25248 Protein denotes IL-4
T16690 25253-25257 Protein denotes IL-5
T16691 25258-25273 Transcription denotes mRNA expression
T16692 25258-25273 Transcription denotes mRNA expression
T16693 25277-25280 Protein denotes CD3
T16694 25281-25285 Protein denotes CD28
T16695 25286-25298 Regulation denotes costimulated
T16696 25286-25298 Regulation denotes costimulated
T16697 25553-25560 Negative_regulation denotes reduces
T16698 25590-25600 Positive_regulation denotes stimulated
T16699 25601-25607 Protein denotes GATA-3
T16700 25611-25620 Binding denotes associate
T16701 25637-25641 Protein denotes IL-5
T16702 25642-25650 Entity denotes promoter
T17478 26758-26765 Negative_regulation denotes reduces
T17479 26758-26765 Negative_regulation denotes reduces
T17480 26766-26772 Protein denotes GATA-3
T17481 26773-26784 Binding denotes association
T17482 26805-26811 Protein denotes GATA-3
T17483 26812-26819 Entity denotes nuclear
T17484 26820-26826 Localization denotes import
T17485 26939-26948 Regulation denotes dependent
T17486 26949-26958 Positive_regulation denotes induction
T17487 26965-26974 Positive_regulation denotes activated
T17488 26975-26977 Protein denotes GR
T17489 26978-26989 Binding denotes interaction
T17490 27038-27040 Protein denotes GR
T17491 27041-27052 Binding denotes association
T17492 27362-27371 Regulation denotes dependent
T17493 27372-27381 Positive_regulation denotes induction
T17494 27388-27397 Positive_regulation denotes activated
T17495 27398-27400 Protein denotes GR
T17496 27401-27408 Entity denotes nuclear
T17497 27409-27422 Localization denotes translocation
T17498 27719-27728 Regulation denotes dependent
T17499 27729-27737 Negative_regulation denotes decrease
T17500 27741-27747 Protein denotes GATA-3
T17501 27759-27770 Binding denotes association
T17502 28009-28015 Protein denotes GATA-3
T17503 28020-28033 Gene_expression denotes overexpressed
T18198 29498-29508 Regulation denotes associated
T18199 29523-29538 Negative_regulation denotes down-regulation
T18200 29542-29548 Protein denotes GATA-3
T18201 29549-29555 Entity denotes serine
T18202 29556-29571 Phosphorylation denotes phosphorylation
T18203 29782-29788 Regulation denotes effect
T18204 29807-29822 Phosphorylation denotes phosphorylation
T18205 29826-29858 Protein denotes activated transcription factor 2
T18206 29860-29865 Protein denotes ATF-2
T18207 29970-29978 Negative_regulation denotes decrease
T18208 30011-30018 Positive_regulation denotes induced
T18209 30019-30025 Entity denotes serine
T18210 30026-30041 Phosphorylation denotes phosphorylation
T18211 30053-30059 Protein denotes GATA-3
T18212 30290-30297 Positive_regulation denotes induced
T18213 30298-30303 Protein denotes MKP-1
T18214 30328-30337 Regulation denotes dependent
T18215 30481-30488 Positive_regulation denotes induces
T18216 30489-30494 Protein denotes MKP-1
T18217 30510-30519 Regulation denotes dependent
T18606 31490-31497 Phosphorylation denotes phospho
T18607 31498-31504 Protein denotes GATA-3
T18608 31597-31599 Protein denotes GR
T18609 31643-31651 Positive_regulation denotes enhances
T18610 31652-31654 Protein denotes GR
T18611 31666-31673 Binding denotes binding
T18612 31723-31729 Protein denotes GATA-3
T18613 31755-31764 Positive_regulation denotes activated
T18614 31765-31767 Protein denotes GR
T18615 31773-31779 Protein denotes GATA-3
T18616 31834-31843 Negative_regulation denotes attenuate true
T18617 31844-31846 Protein denotes GR
T18618 31858-31869 Binding denotes association
T18619 31904-31913 Positive_regulation denotes Activated
T18620 31914-31916 Protein denotes GR
T18621 31917-31923 Negative_regulation denotes blocks
T18622 31948-31955 Phosphorylation denotes phospho
T18623 31956-31962 Protein denotes GATA-3
T18624 32008-32019 Binding denotes interacting
T18625 32098-32104 Protein denotes GATA-3
T18626 32160-32170 Positive_regulation denotes stimulated
T18627 32171-32177 Protein denotes GATA-3
T18628 32187-32194 Binding denotes binding
T18629 32214-32223 Positive_regulation denotes activated
T18630 32235-32247 Positive_regulation denotes unstimulated true
T18631 32252-32254 Protein denotes GR
T18632 32258-32269 Negative_regulation denotes attenuation
T18633 32273-32279 Protein denotes GATA-3
T18634 32291-32302 Binding denotes association
T18635 32321-32330 Regulation denotes dependent
T19230 33294-33300 Regulation denotes affect true
T19231 33301-33307 Protein denotes GATA-3
T19232 33316-33322 Localization denotes export
T19233 33421-33427 Regulation denotes affect true
T19234 33458-33465 Negative_regulation denotes prevent
T19235 33480-33490 Positive_regulation denotes stimulated
T19236 33491-33497 Protein denotes GATA-3
T19237 33498-33505 Entity denotes nuclear
T19238 33506-33518 Localization denotes localization
T20332 38007-38014 Negative_regulation denotes impairs
T20333 38015-38021 Protein denotes GATA-3
T20334 38022-38029 Entity denotes nuclear
T20335 38030-38042 Localization denotes localization
T20336 38140-38142 Protein denotes GR
T20337 38147-38153 Protein denotes GATA-3
T20338 38154-38161 Entity denotes nuclear
T20339 38162-38174 Localization denotes localisation
T20340 38162-38174 Localization denotes localisation
T20341 38188-38194 Protein denotes GATA-3
T20342 38540-38549 Regulation denotes dependent
T20343 38540-38549 Regulation denotes dependent
T20344 38550-38558 Negative_regulation denotes decrease
T20345 38562-38569 Entity denotes nuclear
T20346 38570-38580 Localization denotes expression
T20347 38584-38590 Protein denotes GATA-3
T20348 38596-38605 Positive_regulation denotes increased
T20349 38606-38617 Entity denotes cytoplasmic
T20350 38618-38624 Protein denotes GATA-3
T20351 38625-38635 Localization denotes expression
T20352 38727-38735 Negative_regulation denotes decrease
T20353 38739-38746 Entity denotes nuclear
T20354 38747-38757 Localization denotes expression
T20355 38761-38767 Protein denotes GATA-3
T20356 38783-38794 Entity denotes cytoplasmic
T20357 38795-38801 Protein denotes GATA-3
T20358 38802-38812 Localization denotes expression
T20359 38856-38861 Protein denotes MEK-1
T4329 13206-13209 Protein denotes CD3
T4330 13211-13215 Protein denotes CD28
T4331 13217-13219 Protein denotes GR
T4332 13329-13335 Protein denotes GATA-3
T4333 13347-13349 Protein denotes GR
T4334 13523-13528 Protein denotes ATF-2
T4606 14481-14487 Protein denotes GATA-3
T4607 14488-14500 Localization denotes localization
T4842 14968-14972 Protein denotes IL-4
T5188 15633-15639 Protein denotes GATA-3
T5459 16391-16395 Protein denotes IL-5
T6260 18143-18146 Protein denotes p65
T7155 19780-19786 Protein denotes GATA-3
T7156 19787-19790 Protein denotes GFP
T7157 19805-19811 Protein denotes GATA-3
T7158 19923-19929 Protein denotes GATA-3
T7159 19951-19957 Protein denotes GATA-3
T7160 19987-19991 Protein denotes XhoI
T7161 20075-20080 Protein denotes BamHI
T7162 20161-20167 Protein denotes GATA-3
T7163 20427-20433 Protein denotes GATA-3
T7164 20451-20454 Protein denotes GFP
T7165 20494-20499 Protein denotes EcoRI
T7166 20533-20539 Protein denotes GATA-3
T7167 20595-20598 Protein denotes GFP
T7603 21208-21218 Gene_expression denotes expressing
T7604 21219-21229 Protein denotes GATA-3-GFP
T19239 33698-33704 Regulation denotes affect true
T19240 33716-33722 Protein denotes GATA-3
T19241 33723-33734 Protein_catabolism denotes degradation
T19242 33761-33767 Protein denotes GATA-3
T19243 33978-33985 Negative_regulation denotes prevent true
T19244 34000-34010 Positive_regulation denotes stimulated
T19245 34011-34014 Protein denotes p65
T19246 34015-34022 Entity denotes nuclear
T19247 34023-34036 Localization denotes translocation
T19629 34812-34819 Negative_regulation denotes impairs
T19630 34812-34819 Negative_regulation denotes impairs
T19631 34820-34826 Protein denotes GATA-3
T19632 34827-34838 Binding denotes interaction
T19633 34859-34865 Protein denotes GATA-3
T19634 34866-34873 Entity denotes nuclear
T19635 34874-34886 Localization denotes localization
T19636 35032-35040 Negative_regulation denotes impaired
T19637 35041-35052 Binding denotes interaction
T19638 35061-35067 Protein denotes GATA-3
T19639 35412-35421 Negative_regulation denotes decreased
T19640 35422-35433 Binding denotes association
T19641 35442-35448 Protein denotes GATA-3
R684 T884 T882 themeOf expression,regulating
R686 T885 T881 themeOf expression,regulating
R688 T886 T884 themeOf interleukin (IL)-4,expression
R689 T887 T883 themeOf IL-5,expression
R690 T888 T885 themeOf IL-13,expression
R692 T891 T892 themeOf GATA-3,regulation
R694 T892 T890 themeOf regulation,effect
R695 T894 T895 locationOf nuclear,translocation
R696 T895 T893 themeOf translocation,inhibits
R697 T896 T895 themeOf GATA-3,translocation
R704 T899 T904 themeOf GATA-3,transport
R707 T901 T903 themeOf glucocorticoid receptor,transport
R708 T901 T900 themeOf glucocorticoid receptor,activated
R709 T902 T904 locationOf nuclear,transport
R710 T902 T903 locationOf nuclear,transport
R712 T903 T897 themeOf transport,competition
R714 T904 T898 themeOf transport,competition
R715 T906 T905 themeOf expression,induces
R716 T907 T906 themeOf mitogen-activated protein kinase (MAPK) phosphatase-1,expression
R717 T908 T907 equivalentTo MKP-1,mitogen-activated protein kinase (MAPK) phosphatase-1
R718 T910 T912 themeOf GATA-3,translocation
R720 T911 T912 locationOf nuclear,translocation
R722 T912 T909 themeOf translocation,necessary
R723 T914 T916 themeOf GATA-3,translocation
R724 T915 T916 locationOf nuclear,translocation
R725 T916 T913 themeOf translocation,inhibits
R727 T918 T917 themeOf GATA-3,inhibitory effect
R741 T875 T878 themeOf GATA-3,Phosphorylation
R749 T875 T877 themeOf GATA-3,Import
R751 T876 T877 locationOf Nuclear,Import
R753 T877 T873 themeOf Import,Suppression
R757 T878 T874 themeOf Phosphorylation,Suppression
R760 T879 T882 causeOf GATA-3,regulating
R762 T879 T880 causeOf GATA-3,regulating
R763 T879 T881 causeOf GATA-3,regulating
R766 T883 T880 themeOf expression,regulating
R3043 T3562 T3563 themeOf GATA-3,expressed
R3044 T3564 T3566 causeOf GATA-3,activates
R3045 T3564 T3567 causeOf GATA-3,activates
R3046 T3564 T3565 causeOf GATA-3,activates
R3049 T3568 T3566 themeOf promoters,activates
R3050 T3568 T3570 partOf promoters,IL-5
R3051 T3568 T3567 themeOf promoters,activates
R3052 T3568 T3569 partOf promoters,IL-4
R3053 T3568 T3565 themeOf promoters,activates
R3054 T3568 T3571 partOf promoters,IL-13
R3059 T3578 T3579 themeOf GATA-3,expression
R3060 T3579 T3577 themeOf expression,knockdown
R3062 T3580 T3581 themeOf GATA-3,translocate
R3063 T3580 T3583 themeOf GATA-3,access
R3064 T3580 T3584 themeOf GATA-3,target
R3065 T3582 T3581 locationOf nucleus,translocate
R3069 T3585 T3586 locationOf nuclear,expression
R3070 T3586 T3588 themeOf expression,following
R3071 T3586 T3589 themeOf expression,following
R3073 T3587 T3586 themeOf GATA-3,expression
R3075 T3590 T3591 themeOf GATA-3,transported
R3076 T3592 T3591 locationOf nucleus,transported
R3079 T3595 T3594 themeOf phosphorylating,role
R3080 T3595 T3597 causeOf phosphorylating,enhance
R3081 T3596 T3595 themeOf GATA-3,phosphorylating
R3082 T3596 T3598 themeOf GATA-3,interaction
R3084 T3598 T3597 themeOf interaction,enhance
R3085 T3600 T3599 themeOf glucocorticoid receptors,binding
R3086 T3600 T3602 themeOf glucocorticoid receptors,translocate
R3087 T3600 T3604 themeOf glucocorticoid receptors,interact
R3089 T3601 T3600 equivalentTo GRs,glucocorticoid receptors
R3091 T3603 T3602 locationOf nucleus,translocate
R3092 T3606 T3605 themeOf GR,activated
R3093 T3606 T3607 themeOf GR,interacts
R3094 T3606 T3608 themeOf GR,recruitment
R3096 T3609 T3608 themeOf histone deacetylase-2,recruitment
R3097 T3610 T3611 locationOf Nuclear,localisation
R3098 T3611 T3615 themeOf localisation,mediated
R3099 T3612 T3614 themeOf retention,mediated
R3100 T3613 T3611 themeOf GR,localisation
R3101 T3613 T3612 themeOf GR,retention
R3102 T3613 T3618 themeOf GR,export
R3103 T3616 T3615 causeOf control,mediated
R3104 T3616 T3614 causeOf control,mediated
R3105 T3616 T3621 themeOf control,dependent
R3106 T3617 T3618 locationOf nuclear,export
R3107 T3618 T3616 themeOf export,control
R3108 T3619 T3621 causeOf chromosomal region maintenance 1,dependent
R3109 T3620 T3619 equivalentTo CRM-1,chromosomal region maintenance 1
R3110 T3622 T3623 themeOf NL1,binds
R3111 T3622 T3613 partOf NL1,GR
R3112 T3625 T3626 themeOf GR,translocates
R3113 T3625 T3629 themeOf GR,interaction
R3114 T3626 T3624 themeOf translocates,resulting
R3115 T3626 T3628 themeOf translocates,in response to
R3116 T3627 T3626 locationOf nucleus,translocates
R3117 T3629 T3628 causeOf interaction,in response to
R3118 T3629 T3631 themeOf interaction,requires
R3119 T3630 T3629 themeOf importin 7,interaction
R3120 T3632 T3633 themeOf GR,import
R3121 T3635 T3634 themeOf regulation,important
R3122 T3636 T3637 themeOf GR,activation
R3123 T3637 T3635 themeOf activation,regulation
R3124 T3638 T3641 themeOf IL-4,regulated
R3125 T3639 T3643 themeOf IL-5,regulated
R3126 T3640 T3642 themeOf IL-13,regulated
R3127 T3645 T3646 causeOf GR,reduced
R3128 T3645 T3647 causeOf GR,reduced
R3129 T3648 T3649 causeOf GATA-3,mediated
R3130 T3648 T3650 causeOf GATA-3,mediated
R3131 T3649 T3646 themeOf mediated,reduced
R3132 T3650 T3647 themeOf mediated,reduced
R3133 T3651 T3653 themeOf IL-5,activity
R3134 T3652 T3654 themeOf -13,activity
R3135 T3653 T3649 themeOf activity,mediated
R3136 T3654 T3650 themeOf activity,mediated
R3137 T3656 T3658 causeOf recruitment,alter
R3138 T3657 T3656 themeOf GR,recruitment
R3139 T3659 T3660 themeOf GATA-3,bind
R3140 T3660 T3658 themeOf bind,alter
R3141 T3663 T3664 themeOf GATA-3,phosphorylation
R3142 T3663 T3666 themeOf GATA-3,translocation
R3143 T3664 T3662 themeOf phosphorylation,effects
R3144 T3665 T3666 locationOf nuclear,translocation
R3145 T3666 T3661 themeOf translocation,effects
R3146 T3668 T3669 themeOf GATA-3,localization
R3147 T3669 T3667 themeOf localization,effects
R7591 T8797 T8799 themeOf GATA-3,Translocation
R7592 T8798 T8799 locationOf Nuclear,Translocation
R7593 T8799 T8795 themeOf Translocation,Effect
R7594 T8800 T8796 themeOf IL-4,Effect
R7595 T8802 T8801 themeOf inhibiting,effective
R7596 T8803 T8804 causeOf GATA-3,regulated
R7597 T8804 T8802 themeOf regulated,inhibiting
R7598 T8805 T8806 themeOf IL-4,expression
R7599 T8806 T8804 themeOf expression,regulated
R7600 T8808 T8807 themeOf stimulated,affect
R7601 T8809 T8810 locationOf nuclear,import
R7602 T8810 T8808 themeOf import,stimulated
R7603 T8811 T8810 themeOf GATA-3,import
R7604 T8813 T8815 locationOf nuclear,translocation
R7605 T8814 T8815 themeOf GATA-3,translocation
R7606 T8815 T8812 themeOf translocation,resulted
R7607 T8819 T8818 themeOf loss,caused
R7608 T8820 T8822 locationOf nuclear,expression
R7609 T8821 T8822 themeOf GATA-3,expression
R7610 T8822 T8819 themeOf expression,loss
R7611 T8823 T8824 locationOf cytoplasmic,retention
R7612 T8824 T8817 themeOf retention,caused
R7613 T8825 T8824 themeOf GATA-3,retention
R7614 T8826 T8831 themeOf This effect,dependent
R7615 T8827 T8830 themeOf This effect,dependent
R7616 T8828 T8829 themeOf This effect,dependent
R7617 T8832 T8827 themeOf associated,This effect
R7618 T8833 T8828 themeOf associated,This effect
R7619 T8834 T8826 themeOf associated,This effect
R7620 T8835 T8834 themeOf reductions,associated
R7621 T8836 T8832 themeOf reductions,associated
R7622 T8837 T8835 themeOf stimulated,reductions
R7623 T8838 T8836 themeOf stimulated,reductions
R7624 T8839 T8842 themeOf IL-4,mRNA expression
R7625 T8840 T8841 themeOf IL-5,mRNA expression
R7626 T8841 T8838 themeOf mRNA expression,stimulated
R7627 T8842 T8837 themeOf mRNA expression,stimulated
R7628 T8843 T8833 themeOf loss,associated
R7629 T8844 T8845 themeOf GATA-3,binding
R7630 T8845 T8843 themeOf binding,loss
R7631 T8847 T8845 themeOf promoter,binding
R7632 T8847 T8846 partOf promoter,IL-5
R8068 T9373 T9374 locationOf nuclear,translocation
R8069 T9375 T9379 themeOf decreased,dependent
R8070 T9376 T9375 themeOf association,decreased
R8071 T9376 T9378 themeOf association,induced
R8072 T9377 T9376 themeOf GATA-3,association
R8073 T9381 T9383 themeOf GATA-3,import
R8074 T9382 T9383 locationOf nuclear,import
R8075 T9383 T9384 themeOf import,following
R8076 T9383 T9385 themeOf import,attenuated
R9420 T10993 T10992 themeOf MKP-1,induction
R9421 T10994 T10993 equivalentTo MAPK phosphatase-1,MKP-1
R9422 T10996 T10995 themeOf phosphorylation,decreased
R9423 T10998 T10996 themeOf ATF-2,phosphorylation
R9424 T10998 T10997 themeOf ATF-2,target
R9425 T10999 T11004 themeOf reduced,dependent
R9426 T11001 T11002 themeOf serine,phosphorylation
R9427 T11001 T11000 partOf serine,GATA-3
R9428 T11002 T10999 themeOf phosphorylation,reduced
R9429 T11002 T11003 themeOf phosphorylation,induced
R9430 T11006 T11007 themeOf GATA-3,phosphorylation
R9431 T11007 T11005 themeOf phosphorylation,This reduction
R9432 T11008 T11011 themeOf induced,dependent
R9433 T11009 T11010 themeOf MKP-1,mRNA
R9434 T11010 T11008 themeOf mRNA,induced
R9435 T11015 T11017 themeOf GATA-3,import
R9436 T11015 T11018 themeOf GATA-3,association
R9437 T11016 T11017 locationOf nuclear,import
R9438 T11017 T11014 themeOf import,effects
R9439 T11018 T11012 themeOf association,effects
R9440 T11019 T11020 themeOf IL-4,mRNA expression
R9441 T11020 T11013 themeOf mRNA expression,effects
R9442 T11024 T11021 themeOf GATA-3,competition
R9443 T11024 T11023 themeOf GATA-3,activated
R9444 T11026 T11022 themeOf GR,competition
R9445 T11026 T11025 themeOf GR,activated
R9446 T11028 T11027 themeOf GR,activated
R9447 T11028 T11029 causeOf GR,increased
R9448 T11029 T11032 themeOf increased,in the presence and absence of
R9449 T11030 T11031 themeOf GR,association
R9450 T11031 T11029 themeOf association,increased
R9451 T11033 T11032 causeOf activated,in the presence and absence of
R9452 T11034 T11033 themeOf GATA-3,activated
R9453 T11036 T11035 themeOf GATA-3,activated
R9454 T11036 T11037 causeOf GATA-3,block
R9455 T11038 T11039 themeOf GR,association
R9456 T11039 T11037 themeOf association,block
R9457 T11041 T11040 themeOf GR,activated
R9458 T11041 T11043 themeOf GR,associate
R9459 T11042 T11044 themeOf GATA-3,associate
R9460 T11046 T11045 themeOf GR,activated
R9461 T11046 T11047 causeOf GR,attenuates
R9462 T11047 T11051 themeOf attenuates,dependent
R9463 T11049 T11050 themeOf GATA-3,interaction
R9464 T11049 T11048 themeOf GATA-3,phospho
R9465 T11050 T11047 themeOf interaction,attenuates
R9466 T11053 T11052 themeOf GR,activated
R9467 T11053 T11054 causeOf GR,compete
R9468 T11054 T11057 causeOf compete,limit
R9469 T11055 T11056 themeOf GATA-3,for
R9470 T11056 T11054 themeOf for,compete
R9471 T11058 T11060 themeOf GATA-3,import
R9472 T11059 T11060 locationOf nuclear,import
R9473 T11060 T11057 themeOf import,limit
R9474 T11063 T11065 themeOf GATA-3,export
R9475 T11063 T11066 themeOf GATA-3,degradation
R9476 T11064 T11065 locationOf nuclear,export
R9477 T11065 T11061 themeOf export,effect
R9478 T11066 T11062 themeOf degradation,effect
R9479 T11068 T11067 themeOf block,affect
R9480 T11069 T11071 themeOf GATA-3,localization
R9481 T11070 T11071 locationOf nuclear,localization
R9482 T11071 T11068 themeOf localization,block
R9483 T11073 T11074 themeOf GATA-3,expression
R9484 T11074 T11072 themeOf expression,effect
R9485 T11076 T11078 themeOf GATA-3,residency
R9486 T11077 T11078 locationOf nuclear,residency
R9487 T11078 T11075 themeOf residency,affect
R9488 T11080 T11079 themeOf GR,activated
R9489 T11080 T11081 causeOf GR,enhance
R9490 T11082 T11084 themeOf GATA-3,export
R9491 T11083 T11084 locationOf nuclear,export
R9492 T11084 T11081 themeOf export,enhance
R9493 T11086 T11088 themeOf GATA-3,import
R9494 T11087 T11088 locationOf nuclear,import
R9495 T11088 T11085 themeOf import,effect
R9496 T11090 T11092 themeOf p65,translocation
R9497 T11091 T11092 locationOf nuclear,translocation
R9498 T11092 T11089 themeOf translocation,effect
R10967 T12732 T12734 themeOf GATA-3,Localization
R10968 T12733 T12734 locationOf Nuclear,Localization
R10969 T12734 T12731 themeOf Localization,Inhibitory
R10970 T12736 T12735 themeOf decrease,dependent
R10971 T12737 T12736 themeOf interaction,decrease
R10972 T12737 T12740 themeOf interaction,inhibited
R10973 T12737 T12741 themeOf interaction,attenuated
R10974 T12739 T12737 themeOf GATA-3,interaction
R10975 T12739 T12738 themeOf GATA-3,phospho
R10976 T12744 T12747 themeOf IL-4,expression
R10977 T12745 T12746 themeOf -5,expression
R10978 T12746 T12742 themeOf expression,suppresses
R10979 T12747 T12743 themeOf expression,suppresses
R10980 T12749 T12748 themeOf interaction,attenuated
R10981 T12750 T12749 themeOf GATA-3,interaction
R10982 T12751 T12754 themeOf reduced,dependent
R10983 T12752 T12753 themeOf GATA-3,interaction
R10984 T12753 T12751 themeOf interaction,reduced
R10985 T12756 T12755 themeOf decrease,produced
R10986 T12757 T12758 themeOf GATA-3,association
R10987 T12758 T12756 themeOf association,decrease
R10988 T12759 T12760 themeOf GATA-3,association
R10989 T12762 T12761 themeOf interaction,attenuated
R10990 T12763 T12762 themeOf GATA-3,interaction
R10991 T12765 T12764 themeOf localization,affect
R10992 T12766 T12765 themeOf GATA-3,localization
R10993 T12768 T12770 themeOf GR,translocation
R10994 T12769 T12770 locationOf nuclear,translocation
R10995 T12770 T12767 themeOf translocation,increased
R10996 T12773 T12772 themeOf loss,induced
R10997 T12774 T12773 locationOf nuclear,loss
R10998 T12775 T12773 themeOf GATA-3,loss
R10999 T12776 T12778 locationOf cytoplasmic,levels
R11000 T12777 T12778 themeOf GATA-3,levels
R11001 T12778 T12779 themeOf levels,enhanced
R11002 T12779 T12780 themeOf enhanced,dependent
R11003 T12782 T12783 locationOf nuclear,localization
R11004 T12783 T12781 themeOf localization,reduces
R11005 T12784 T12783 themeOf GATA-3,localization
R11006 T12785 T12781 causeOf inhibiting,reduces
R11007 T12786 T12787 themeOf GATA-3,association
R11008 T12787 T12785 themeOf association,inhibiting
R11009 T12789 T12790 themeOf GATA-3,phosphorylation
R11010 T12790 T12788 themeOf phosphorylation,mediated
R11011 T12792 T12791 themeOf MKP-1,induction
R11012 T12794 T12793 themeOf suppression,effects
R11013 T12795 T12797 themeOf GATA-3,import
R11014 T12796 T12797 locationOf nuclear,import
R11015 T12797 T12794 themeOf import,suppression
R13552 T15785 T15784 themeOf GR,activated
R13553 T15785 T15786 causeOf GR,compete
R13555 T15788 T15786 themeOf GATA-3,compete
R13558 T15788 T15787 themeOf GATA-3,activated
R13559 T15788 T15790 themeOf GATA-3,import
R13560 T15789 T15790 locationOf nuclear,import
R13562 T15790 T15791 themeOf import,via
R13564 T15794 T15796 locationOf nuclear,transport
R13565 T15794 T15795 locationOf nuclear,transport
R13566 T15795 T15792 themeOf transport,required
R13568 T15796 T15793 themeOf transport,required
R13569 T15797 T15796 themeOf GATA-3,transport
R13570 T15798 T15795 themeOf GR,transport
R13572 T15800 T15799 themeOf expression,increase
R13573 T15801 T15800 themeOf MKP-1,expression
R13576 T15803 T15802 themeOf phosphorylation,prevent
R13577 T15803 T15805 causeOf phosphorylation,necessary
R13578 T15803 T15806 causeOf phosphorylation,necessary
R13579 T15804 T15803 themeOf GATA-3,phosphorylation
R13580 T15804 T15807 themeOf GATA-3,interaction
R13581 T15804 T15810 themeOf GATA-3,import
R13583 T15807 T15805 themeOf interaction,necessary
R13584 T15807 T15808 causeOf interaction,subsequent
R13585 T15809 T15810 locationOf nuclear,import
R13587 T15810 T15806 themeOf import,necessary
R13588 T15810 T15808 themeOf import,subsequent
R13589 T15811 T15814 themeOf translocation,involves
R13590 T15812 T15811 themeOf GATA-3,translocation
R13591 T15813 T15811 locationOf nucleus,translocation
R13592 T15817 T15815 themeOf GATA-3,interacts
R13593 T15817 T15816 themeOf GATA-3,phosphorylated
R13594 T15818 T15819 themeOf GATA-3,knockdown
R13596 T15819 T15820 causeOf knockdown,suppression
R13597 T15819 T15821 causeOf knockdown,suppression
R13598 T15822 T15821 themeOf stimulated,suppression
R13600 T15823 T15820 themeOf stimulated,suppression
R13601 T15824 T15826 themeOf IL-4,induction
R13602 T15824 T15832 themeOf IL-4,transcription
R13603 T15825 T15827 themeOf IL-5,induction
R13604 T15825 T15831 themeOf IL-5,transcription
R13606 T15826 T15823 themeOf induction,stimulated
R13607 T15827 T15822 themeOf induction,stimulated
R13609 T15830 T15829 causeOf GATA-3,role
R13610 T15830 T15828 causeOf GATA-3,role
R13611 T15831 T15828 themeOf transcription,role
R13612 T15832 T15829 themeOf transcription,role
R13613 T15833 T15835 themeOf GR,import
R13614 T15834 T15835 locationOf nuclear,import
R13616 T15838 T15837 causeOf GR,competition
R13618 T15840 T15842 themeOf GATA-3,import
R13619 T15840 T15839 themeOf GATA-3,phospho
R13620 T15841 T15842 locationOf nuclear,import
R13621 T15842 T15837 themeOf import,competition
R13622 T15883 T15884 themeOf MKP-1,induction
R13623 T15846 T15843 themeOf GR,binding
R13624 T15846 T15845 themeOf GR,activated
R13625 T15848 T15844 themeOf GATA-3,binding
R13626 T15848 T15847 themeOf GATA-3,phospho
R13627 T15850 T15851 themeOf GATA-3,entry
R13628 T15884 T15882 themeOf induction,role
R13629 T15851 T15849 themeOf entry,reduce
R13630 T15853 T15854 locationOf nuclear,translocation
R13631 T15886 T15885 themeOf MKP-1,induction
R13632 T15854 T15856 themeOf translocation,affected
R13633 T15855 T15854 themeOf p65,translocation
R13634 T15858 T15860 themeOf GATA-3,exclusion
R13635 T15887 T15889 themeOf induction,following
R13636 T15859 T15860 locationOf nuclear,exclusion
R13637 T15860 T15857 themeOf exclusion,this effect
R13638 T15888 T15887 themeOf MKP-1,induction
R13639 T15862 T15864 themeOf GATA-3,export
R13640 T15863 T15864 locationOf nuclear,export
R13641 T15864 T15861 themeOf export,enhances
R13642 T15866 T15867 themeOf GATA-3,degradation
R13643 T15890 T15896 causeOf induction,attenuating
R13644 T15867 T15865 themeOf degradation,induces
R13645 T15869 T15868 themeOf GR,activated
R13646 T15869 T15870 causeOf GR,attenuate
R13647 T15891 T15890 themeOf MKP-1,induction
R13648 T15872 T15873 themeOf GATA-3,association
R13649 T15872 T15871 themeOf GATA-3,phospho
R13650 T15873 T15870 themeOf association,attenuate
R13651 T15893 T15902 themeOf GATA-3,translocation
R13652 T15875 T15874 themeOf GATA-3,phospho
R13653 T15875 T15876 themeOf GATA-3,associate
R13654 T15878 T15877 themeOf reduction,contribute
R13655 T15879 T15881 themeOf GATA-3,import
R13656 T15880 T15881 locationOf nuclear,import
R13657 T15893 T15895 themeOf GATA-3,import
R13658 T15881 T15878 themeOf import,reduction
R13659 T15894 T15895 locationOf nuclear,import
R13660 T15895 T15892 themeOf import,reduce
R13661 T15896 T15900 causeOf attenuating,preventing
R13662 T15896 T15892 causeOf attenuating,reduce
R13663 T15897 T15896 themeOf subsequent,attenuating
R13664 T15898 T15899 themeOf GATA-3,phosphorylation
R13665 T15899 T15897 themeOf phosphorylation,subsequent
R13666 T15901 T15902 locationOf nuclear,translocation
R13667 T15902 T15900 themeOf translocation,preventing
R13668 T15903 T15905 themeOf serine residue,phosphorylated
R13669 T15903 T15904 partOf serine residue,GATA-3
R13670 T15907 T15909 themeOf GATA-3,import
R13671 T15908 T15909 locationOf nuclear,import
R13672 T15909 T15906 themeOf import,impairment
R13673 T15911 T15910 themeOf expression,inhibitory effect
R13674 T15912 T15911 themeOf IL-4,expression
R13675 T15914 T15915 themeOf IL-4,transcription
R13676 T15915 T15913 themeOf transcription,suppress
R13677 T15916 T15917 themeOf GATA-3,inhibition
R13678 T15919 T15918 themeOf GATA-3,inhibiting
R13679 T15922 T15924 themeOf IL-4,release
R13680 T15923 T15925 themeOf IL-5,release
R13681 T15924 T15921 themeOf release,suppress
R13682 T15925 T15920 themeOf release,suppress
R13683 T15928 T15930 themeOf GATA-3,translocation
R13684 T15928 T15931 themeOf GATA-3,binding
R13685 T15929 T15930 locationOf nuclear,translocation
R13686 T15930 T15927 themeOf translocation,inhibitory effect
R13687 T15930 T15926 themeOf translocation,inhibitory effect
R13688 T15931 T15927 causeOf binding,inhibitory effect
R13689 T15932 T15926 causeOf increased,inhibitory effect
R13690 T15932 T15935 causeOf increased,preventing
R13691 T15933 T15932 themeOf synthesis,increased
R13692 T15934 T15933 themeOf MKP-1,synthesis
R13693 T15936 T15935 themeOf phosphorylation,preventing
R13694 T15937 T15936 themeOf GATA-3,phosphorylation
R13695 T15939 T15940 locationOf nuclear,translocation
R13696 T15940 T15938 themeOf translocation,necessary
R13697 T15941 T15940 themeOf GATA-3,translocation
R13698 T15944 T15945 themeOf GATA-3,interaction
R13699 T15944 T15943 themeOf GATA-3,phospho
R13700 T15945 T15942 themeOf interaction,Prevention
R14316 T16675 T16677 themeOf GATA-3,import
R14317 T16676 T16677 locationOf nuclear,import
R14318 T16677 T16674 themeOf import,inhibits
R14319 T16679 T16678 themeOf GATA-3,translocation
R14320 T16680 T16678 locationOf nucleus,translocation
R14321 T16682 T16683 locationOf nuclear,localization
R14322 T16683 T16685 themeOf localization,induced
R14323 T16684 T16683 themeOf GATA-3,localization
R14324 T16689 T16691 themeOf IL-4,mRNA expression
R14325 T16690 T16692 themeOf IL-5,mRNA expression
R14326 T16691 T16688 themeOf mRNA expression,inhibits
R14327 T16692 T16687 themeOf mRNA expression,inhibits
R14328 T16693 T16696 themeOf CD3,costimulated
R14329 T16694 T16695 themeOf CD28,costimulated
R14330 T16699 T16700 themeOf GATA-3,associate
R14331 T16699 T16698 themeOf GATA-3,stimulated
R14332 T16700 T16697 themeOf associate,reduces
R14333 T16702 T16700 themeOf promoter,associate
R14334 T16702 T16701 partOf promoter,IL-5
R15003 T17480 T17481 themeOf GATA-3,association
R15004 T17481 T17478 themeOf association,reduces
R15005 T17482 T17484 themeOf GATA-3,import
R15006 T17483 T17484 locationOf nuclear,import
R15007 T17484 T17479 themeOf import,reduces
R15008 T17486 T17485 themeOf induction,dependent
R15009 T17488 T17489 themeOf GR,interaction
R15010 T17488 T17487 themeOf GR,activated
R15011 T17489 T17486 themeOf interaction,induction
R15012 T17490 T17491 themeOf GR,association
R15013 T17493 T17492 themeOf induction,dependent
R15014 T17495 T17497 themeOf GR,translocation
R15015 T17495 T17494 themeOf GR,activated
R15016 T17496 T17497 locationOf nuclear,translocation
R15017 T17497 T17493 themeOf translocation,induction
R15018 T17499 T17498 themeOf decrease,dependent
R15019 T17500 T17501 themeOf GATA-3,association
R15020 T17501 T17499 themeOf association,decrease
R15021 T17502 T17503 themeOf GATA-3,overexpressed
R15590 T18199 T18198 themeOf down-regulation,associated
R15591 T18201 T18202 themeOf serine,phosphorylation
R15592 T18201 T18200 partOf serine,GATA-3
R15593 T18202 T18199 themeOf phosphorylation,down-regulation
R15594 T18204 T18203 themeOf phosphorylation,effect
R15595 T18205 T18204 themeOf activated transcription factor 2,phosphorylation
R15596 T18206 T18205 equivalentTo ATF-2,activated transcription factor 2
R15597 T18209 T18211 partOf serine,GATA-3
R15598 T18209 T18210 themeOf serine,phosphorylation
R15599 T18210 T18208 themeOf phosphorylation,induced
R15600 T18210 T18207 themeOf phosphorylation,decrease
R15601 T18212 T18214 themeOf induced,dependent
R15602 T18213 T18212 themeOf MKP-1,induced
R15603 T18215 T18217 themeOf induces,dependent
R15604 T18216 T18215 themeOf MKP-1,induces
R15907 T18607 T18606 themeOf GATA-3,phospho
R15908 T18608 T18609 causeOf GR,enhances
R15909 T18610 T18611 themeOf GR,binding
R15910 T18611 T18609 themeOf binding,enhances
R15911 T18614 T18613 themeOf GR,activated
R15912 T18615 T18616 causeOf GATA-3,attenuate
R15913 T18617 T18618 themeOf GR,association
R15914 T18618 T18616 themeOf association,attenuate
R15915 T18620 T18621 causeOf GR,blocks
R15916 T18620 T18619 themeOf GR,Activated
R15917 T18623 T18624 themeOf GATA-3,interacting
R15918 T18623 T18622 themeOf GATA-3,phospho
R15919 T18624 T18621 themeOf interacting,blocks
R15920 T18627 T18628 themeOf GATA-3,binding
R15921 T18628 T18626 themeOf binding,stimulated
R15922 T18631 T18629 themeOf GR,activated
R15923 T18631 T18630 themeOf GR,unstimulated
R15924 T18631 T18632 causeOf GR,attenuation
R15925 T18632 T18635 themeOf attenuation,dependent
R15926 T18633 T18634 themeOf GATA-3,association
R15927 T18634 T18632 themeOf association,attenuation
R16418 T19231 T19232 themeOf GATA-3,export
R16419 T19232 T19230 themeOf export,affect
R16420 T19234 T19233 themeOf prevent,affect
R16421 T19236 T19238 themeOf GATA-3,localization
R16422 T19237 T19238 locationOf nuclear,localization
R16423 T19238 T19234 themeOf localization,prevent
R16424 T19238 T19235 themeOf localization,stimulated
R16425 T19240 T19241 themeOf GATA-3,degradation
R16426 T19241 T19239 themeOf degradation,affect
R16427 T19245 T19247 themeOf p65,translocation
R16428 T19246 T19247 locationOf nuclear,translocation
R16429 T19247 T19243 themeOf translocation,prevent
R16430 T19247 T19244 themeOf translocation,stimulated
R16769 T19631 T19632 themeOf GATA-3,interaction
R16770 T19632 T19629 themeOf interaction,impairs
R16771 T19633 T19635 themeOf GATA-3,localization
R16772 T19634 T19635 locationOf nuclear,localization
R16773 T19635 T19630 themeOf localization,impairs
R16774 T19637 T19636 themeOf interaction,impaired
R16775 T19638 T19637 themeOf GATA-3,interaction
R16776 T19640 T19639 themeOf association,decreased
R16777 T19641 T19640 themeOf GATA-3,association
R17384 T20333 T20335 themeOf GATA-3,localization
R17385 T20334 T20335 locationOf nuclear,localization
R17386 T20335 T20332 themeOf localization,impairs
R17387 T20336 T20339 themeOf GR,localisation
R17388 T20337 T20340 themeOf GATA-3,localisation
R17389 T20338 T20339 locationOf nuclear,localisation
R17390 T20338 T20340 locationOf nuclear,localisation
R17391 T20344 T20342 themeOf decrease,dependent
R17392 T20345 T20346 locationOf nuclear,expression
R17393 T20346 T20344 themeOf expression,decrease
R17394 T20347 T20346 themeOf GATA-3,expression
R17395 T20348 T20343 themeOf increased,dependent
R17396 T20349 T20351 locationOf cytoplasmic,expression
R17397 T20350 T20351 themeOf GATA-3,expression
R17398 T20351 T20348 themeOf expression,increased
R17399 T20353 T20354 locationOf nuclear,expression
R17400 T20354 T20352 themeOf expression,decrease
R17401 T20355 T20354 themeOf GATA-3,expression
R17402 T20356 T20358 locationOf cytoplasmic,expression
R17403 T20357 T20358 themeOf GATA-3,expression
R3967 T4606 T4607 themeOf GATA-3,localization
R6532 T7604 T7603 themeOf GATA-3-GFP,expressing
R8059 T9361 T9362 themeOf GATA-3,for
R8060 T9364 T9363 themeOf GR,activated
R8061 T9364 T9370 themeOf GR,import
R8062 T9365 T9369 themeOf GATA-3,import
R8063 T9368 T9370 locationOf nuclear,import
R8064 T9368 T9369 locationOf nuclear,import
R8065 T9369 T9366 themeOf import,uses
R8066 T9370 T9367 themeOf import,uses
R8067 T9372 T9374 themeOf GR,translocation

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T919 15-36 Protein denotes GATA-3 Nuclear Import
T920 0-11 Negative_regulation denotes Suppression
T921 41-56 Phosphorylation denotes Phosphorylation
T922 0-11 Negative_regulation denotes Suppression
T923 466-472 Protein denotes GATA-3
T924 541-565 Protein denotes interleukin (IL)-4, IL-5
T925 513-523 Gene_expression denotes expression
T926 498-508 Regulation denotes regulating
T927 755-761 Protein denotes GATA-3
T928 744-751 Regulation denotes effects
T929 850-856 Protein denotes GATA-3
T930 857-867 Regulation denotes regulation
T931 795-801 Regulation denotes effect
T932 1025-1033 Protein denotes anti-CD3
T933 1038-1047 Protein denotes anti-CD28
T934 1124-1130 Protein denotes GATA-3
T935 1194-1211 Protein denotes nuclear factor-κB
T936 1256-1262 Protein denotes GATA-3
T937 1288-1311 Protein denotes glucocorticoid receptor
T938 1099-1106 Entity denotes nuclear
T939 1107-1120 Localization denotes translocation
T940 1271-1287 Positive_regulation denotes ligand-activated
T941 1090-1098 Negative_regulation denotes inhibits
T942 1426-1458 Protein denotes mitogen-activated protein kinase
T943 1460-1464 Protein denotes MAPK
T944 1517-1525 Protein denotes p38 MAPK
T945 1412-1422 Gene_expression denotes expression
T946 1412-1422 Gene_expression denotes expression
T947 1504-1513 Negative_regulation denotes inhibitor
T948 1565-1578 Localization denotes translocation
T949 1400-1407 Positive_regulation denotes induces
T950 1400-1407 Positive_regulation denotes induces
T951 1536-1545 Positive_regulation denotes necessary
T952 1867-1873 Protein denotes GATA-3
T953 1928-1931 Protein denotes Th2
T954 1857-1863 Negative_regulation denotes effect
T955 1941-1951 Gene_expression denotes expression
T956 1919-1927 Negative_regulation denotes suppress
T4335 13200-13209 Protein denotes human CD3
T4336 13211-13215 Protein denotes CD28
T4337 13217-13219 Protein denotes GR
T4338 13225-13235 Protein denotes importin-α
T4339 13347-13349 Protein denotes GR
T4839 14725-14730 Protein denotes RNase
T4840 14968-14972 Protein denotes IL-4
T4841 15027-15032 Protein denotes GADPH
T6056 16720-16730 Protein denotes Importin-α
T6057 16770-16780 Protein denotes importin-α
T6058 16938-16944 Protein denotes GATA-3
T6059 17031-17034 Protein denotes CD3
T6060 17035-17039 Protein denotes CD28
T6061 17044-17046 Protein denotes GR
T6062 17262-17291 Protein denotes goat anti-importin-α antibody
T6063 17397-17407 Protein denotes importin-α
T6064 17740-17766 Protein denotes FITC swine anti-rabbit IgG
T6065 17819-17825 Protein denotes GATA-3
T6066 17859-17862 Protein denotes IgG
T6067 17927-17929 Protein denotes GR
T6068 17806-17815 Gene_expression denotes detection
T6069 17914-17923 Gene_expression denotes detection
T6070 17793-17797 Positive_regulation denotes used
T6732 19564-19584 Protein denotes serum immunoglobulin
T6733 19586-19590 Protein denotes Dako
T7141 19908-19912 Protein denotes XhoI
T7142 19923-19929 Protein denotes GATA-3
T7143 19937-19949 Protein denotes pOTB7 vector
T7144 19951-19957 Protein denotes GATA-3
T7145 19975-19991 Protein denotes pOTB7 using XhoI
T7146 20006-20014 Protein denotes pEGFP-C2
T7147 20075-20080 Protein denotes BamHI
T7148 19962-19969 Negative_regulation denotes excised
T7149 19962-19969 Negative_regulation denotes excised
T7150 20161-20176 Protein denotes GATA-3 fragment
T7151 20185-20190 Protein denotes pEGFP
T7152 20191-20193 Protein denotes C2
T7153 20494-20499 Protein denotes EcoRI
T7154 20533-20548 Protein denotes GATA-3 fragment
T8093 22964-22966 Protein denotes FP
T8773 23205-23233 Protein denotes GATA-3 Nuclear Translocation
T8774 23238-23247 Protein denotes IL-4 mRNA
T8775 23176-23182 Regulation denotes Effect
T8776 23176-23182 Regulation denotes Effect
T8777 23292-23318 Protein denotes GATA-3-regulated IL-4 gene
T8778 23319-23329 Gene_expression denotes expression
T8779 23281-23291 Negative_regulation denotes inhibiting
T8780 23414-23422 Protein denotes anti-CD3
T8781 23423-23427 Protein denotes CD28
T8782 23457-23463 Protein denotes GATA-3
T8783 23439-23446 Entity denotes nuclear
T8784 23447-23453 Localization denotes import
T8785 23447-23453 Localization denotes import
T8786 23407-23413 Regulation denotes affect
T8787 23407-23413 Regulation denotes affect
T8788 23496-23499 Protein denotes CD3
T8789 23500-23504 Protein denotes CD28
T8790 23705-23715 Protein denotes histone H1
T8791 23720-23725 Protein denotes MEK-1
T8792 23864-23870 Protein denotes GATA-3
T8793 23851-23860 Localization denotes retention
T8794 23801-23805 Negative_regulation denotes loss
T8848 24143-24146 Protein denotes CD3
T8849 24147-24151 Protein denotes CD28
T8850 24163-24167 Protein denotes IL-4
T8851 24172-24181 Protein denotes IL-5 mRNA
T8852 24219-24225 Protein denotes GATA-3
T8853 24248-24261 Protein denotes IL-5 promoter
T8854 24182-24192 Gene_expression denotes expression
T8855 24182-24192 Gene_expression denotes expression
T8856 24211-24215 Negative_regulation denotes loss
T8857 24226-24233 Binding denotes binding
T8858 24226-24233 Binding denotes binding
T8859 24124-24134 Negative_regulation denotes reductions
T8860 24124-24134 Negative_regulation denotes reductions
T8861 24152-24162 Positive_regulation denotes stimulated
T8862 24152-24162 Positive_regulation denotes stimulated
T8863 24211-24215 Negative_regulation denotes loss
T8864 24211-24215 Negative_regulation denotes loss
T9334 25841-25843 Protein denotes GR
T9335 25858-25864 Protein denotes GATA-3
T9336 25869-25879 Protein denotes Importin-α
T9337 25824-25840 Positive_regulation denotes Ligand-Activated
T9338 25955-25957 Protein denotes GR
T9339 25969-25975 Protein denotes GATA-3
T9340 25981-25991 Protein denotes importin-α
T9341 25938-25954 Positive_regulation denotes ligand-activated
T9342 25938-25954 Positive_regulation denotes ligand-activated
T9343 26000-26007 Entity denotes nuclear
T9344 26008-26014 Localization denotes import
T9345 26060-26062 Protein denotes GR
T9346 26067-26077 Protein denotes importin-α
T9347 26040-26051 Binding denotes interaction
T9348 26173-26175 Protein denotes GR
T9349 26176-26183 Entity denotes nuclear
T9350 26184-26197 Localization denotes translocation
T9351 26369-26375 Protein denotes GATA-3
T9352 26380-26390 Protein denotes importin-α
T9353 26407-26410 Protein denotes CD3
T9354 26411-26415 Protein denotes CD28
T9355 26349-26360 Binding denotes association
T9356 26335-26344 Negative_regulation denotes decreased
T9357 26509-26515 Protein denotes GATA-3
T9358 26598-26601 Protein denotes CD3
T9359 26602-26606 Protein denotes CD28
T10943 29020-29022 Protein denotes FP
T10944 28961-28976 Phosphorylation denotes phosphorylation
T10945 28941-28950 Negative_regulation denotes reduction
T10946 29038-29040 Protein denotes FP
T10947 29063-29073 Protein denotes MKP-1 mRNA
T10948 29055-29062 Positive_regulation denotes induced
T10949 29268-29277 Protein denotes IL-4 mRNA
T10950 29278-29288 Gene_expression denotes expression
T10951 29201-29208 Regulation denotes effects
T10952 30745-30751 Protein denotes GATA-3
T10953 30753-30763 Protein denotes importin-α
T10954 30779-30781 Protein denotes GR
T10955 30814-30816 Protein denotes GR
T10956 30841-30843 Protein denotes GR
T10957 30735-30744 Positive_regulation denotes activated
T10958 30735-30744 Positive_regulation denotes activated
T10959 30769-30778 Positive_regulation denotes activated
T10960 30804-30813 Positive_regulation denotes activated
T10961 30971-30977 Protein denotes GATA-3
T10962 30992-30994 Protein denotes GR
T10963 30961-30970 Positive_regulation denotes activated
T10964 31075-31077 Protein denotes GR
T10965 31167-31169 Protein denotes GR
T10966 31065-31074 Positive_regulation denotes activated
T10967 31110-31119 Binding denotes associate
T10968 31157-31166 Positive_regulation denotes activated
T10969 31318-31320 Protein denotes GR
T10970 31301-31317 Positive_regulation denotes ligand-activated
T10971 32693-32695 Protein denotes FP
T10972 32671-32677 Regulation denotes affect
T10973 32712-32719 Entity denotes nuclear
T10974 32760-32762 Protein denotes FP
T10975 32798-32808 Gene_expression denotes expression
T10976 32770-32776 Regulation denotes effect
T10977 32886-32888 Protein denotes FP
T10978 32908-32911 Protein denotes CD3
T10979 32912-32916 Protein denotes CD28
T10980 33010-33012 Protein denotes GR
T10981 32917-32924 Entity denotes nuclear
T10982 32925-32938 Localization denotes translocation
T10983 32925-32938 Localization denotes translocation
T10984 32925-32938 Localization denotes translocation
T10985 33000-33009 Positive_regulation denotes activated
T10986 33160-33163 Protein denotes p65
T10987 33089-33096 Entity denotes nuclear
T10988 33164-33171 Entity denotes nuclear
T10989 33172-33185 Localization denotes translocation
T10990 33150-33156 Regulation denotes effect
T12798 34494-34508 Protein denotes phospho-GATA-3
T12799 34513-34523 Protein denotes importin-α
T12800 34474-34485 Binding denotes interaction
T12801 34451-34459 Negative_regulation denotes decrease
T12802 35748-35752 Protein denotes M FP
T12803 35764-35768 Protein denotes IL-4
T12804 35826-35832 Protein denotes GATA-3
T12805 35838-35848 Protein denotes importin-α
T12806 35781-35791 Gene_expression denotes expression
T12807 35811-35822 Binding denotes interaction
T12808 35753-35763 Negative_regulation denotes suppresses
T12809 35796-35806 Negative_regulation denotes attenuated
T12810 36086-36101 Protein denotes GATA-3–importin
T12811 36102-36103 Protein denotes α
T12812 36104-36115 Binding denotes interaction
T12813 36078-36085 Negative_regulation denotes reduced
T12814 36185-36200 Protein denotes GATA-3–importin
T12815 36625-36631 Protein denotes GATA-3
T12816 36679-36689 Protein denotes importin-α
T12817 36737-36747 Protein denotes importin-α
T12818 36610-36621 Binding denotes interaction
T12819 36724-36733 Localization denotes abundance
T12820 36708-36716 Negative_regulation denotes decrease
T12821 36879-36885 Protein denotes GATA-3
T12822 36854-36862 Entity denotes cellular
T12823 36863-36875 Localization denotes localization
T12824 36982-36984 Protein denotes GR
T12825 36985-36992 Entity denotes nuclear
T12826 36993-37006 Localization denotes translocation
T12827 36972-36981 Positive_regulation denotes increased
T12828 37591-37609 Protein denotes cytoplasmic GATA-3
T12829 37642-37644 Protein denotes FP
T12830 37452-37459 Entity denotes nuclear
T12831 37622-37630 Positive_regulation denotes enhanced
T12832 37831-37839 Protein denotes p38 MAPK
T12833 37840-37855 Phosphorylation denotes phosphorylation
T12834 37821-37830 Negative_regulation denotes inhibited
T12835 39499-39505 Protein denotes GATA-3
T12836 39475-39482 Entity denotes nuclear
T12837 39483-39495 Localization denotes localization
T12838 39467-39474 Negative_regulation denotes reduces
T12839 39624-39634 Protein denotes importin-α
T12840 39689-39692 Protein denotes p38
T12841 39753-39758 Protein denotes MKP-1
T12842 39608-39619 Binding denotes competition
T12843 39714-39729 Phosphorylation denotes phosphorylation
T12844 39740-39749 Positive_regulation denotes induction
T15646 40017-40023 Protein denotes GATA-3
T15647 40068-40077 Protein denotes Th2 genes
T15648 40051-40064 Transcription denotes transcription
T15649 40167-40169 Protein denotes GR
T15650 40204-40210 Protein denotes GATA-3
T15651 40298-40304 Protein denotes GATA-3
T15652 40309-40311 Protein denotes GR
T15653 40181-40188 Binding denotes compete
T15654 40194-40203 Positive_regulation denotes activated
T15655 40215-40222 Entity denotes nuclear
T15656 40272-40279 Entity denotes nuclear
T15657 40280-40289 Localization denotes transport
T15658 40280-40289 Localization denotes transport
T15659 40255-40263 Positive_regulation denotes required
T15660 40255-40263 Positive_regulation denotes required
T15661 40391-40396 Protein denotes MKP-1
T15662 40420-40428 Protein denotes p38 MAPK
T15663 40458-40485 Protein denotes T cell receptor/co-receptor
T15664 40500-40508 Protein denotes p38 MAPK
T15665 40543-40549 Protein denotes GATA-3
T15666 40589-40599 Protein denotes importin-α
T15667 40377-40387 Gene_expression denotes expression
T15668 40407-40416 Negative_regulation denotes inhibitor
T15669 40486-40496 Positive_regulation denotes activation
T15670 40524-40539 Phosphorylation denotes phosphorylation
T15671 40572-40583 Binding denotes interaction
T15672 40615-40622 Entity denotes nuclear
T15673 40623-40629 Localization denotes import
T15674 40364-40372 Positive_regulation denotes increase
T15675 40450-40457 Negative_regulation denotes prevent
T15676 40512-40519 Negative_regulation denotes prevent
T15677 40558-40567 Positive_regulation denotes necessary
T15678 40678-40684 Protein denotes GATA-3
T15679 40732-40770 Protein denotes nuclear transporter protein importin-α
T15680 40711-40718 Entity denotes nucleus
T15681 40778-40787 Binding denotes interacts
T15682 40661-40674 Localization denotes translocation
T15683 40859-40865 Protein denotes GATA-3
T15684 40919-40922 Protein denotes CD3
T15685 40923-40927 Protein denotes CD28
T15686 40939-40953 Protein denotes IL-4/IL-5 mRNA
T15687 41004-41010 Protein denotes GATA-3
T15688 40866-40875 Negative_regulation denotes knockdown
T15689 41018-41031 Transcription denotes transcription
T15690 41092-41094 Protein denotes GR
T15691 41227-41229 Protein denotes GR
T15692 41334-41344 Protein denotes importin-α
T15693 41358-41360 Protein denotes GR
T15694 41475-41483 Protein denotes Th2 gene
T15695 41323-41330 Binding denotes binding
T15696 41323-41330 Binding denotes binding
T15697 41348-41357 Positive_regulation denotes activated
T15698 41348-41357 Positive_regulation denotes activated
T15699 41348-41357 Positive_regulation denotes activated
T15700 41484-41497 Transcription denotes transcription
T15701 41464-41470 Negative_regulation denotes switch
T15702 41464-41470 Positive_regulation denotes switch
T15703 41597-41603 Protein denotes GATA-3
T15704 41637-41648 Protein denotes p65 subunit
T15705 41652-41657 Protein denotes NF-κB
T15706 41608-41615 Entity denotes nuclear
T15707 41616-41629 Localization denotes translocation
T15708 41616-41629 Localization denotes translocation
T15709 41666-41674 Regulation denotes affected
T15710 41666-41674 Regulation denotes affected
T15711 41762-41764 Protein denotes FP
T15712 41768-41774 Protein denotes GATA-3
T15713 41878-41884 Protein denotes GATA-3
T15714 41775-41782 Entity denotes nuclear
T15715 41783-41792 Localization denotes exclusion
T15716 41885-41896 Protein_catabolism denotes degradation
T15717 41870-41877 Positive_regulation denotes induces
T15718 41995-41997 Protein denotes GR
T15719 41985-41994 Positive_regulation denotes activated
T15720 42176-42186 Protein denotes importin-α
T15721 42161-42170 Binding denotes associate
T15722 42521-42526 Protein denotes MKP-1
T15723 42527-42536 Positive_regulation denotes induction
T15724 42567-42575 Protein denotes p38 MAPK
T15725 42610-42615 Protein denotes MKP-1
T15726 42650-42654 Protein denotes MAPK
T15727 42597-42606 Positive_regulation denotes induction
T15728 42637-42646 Negative_regulation denotes inhibitor
T15729 42558-42566 Regulation denotes modulate
T15730 42597-42606 Positive_regulation denotes induction
T15731 42711-42721 Protein denotes MKP-1 mRNA
T15732 42792-42794 Protein denotes FP
T15733 42698-42707 Positive_regulation denotes induction
T15734 42840-42845 Protein denotes MKP-1
T15735 42894-42902 Protein denotes p38 MAPK
T15736 42827-42836 Positive_regulation denotes induction
T15737 42864-42871 Entity denotes nuclear
T15738 42882-42893 Positive_regulation denotes attenuating
T15739 42934-42949 Phosphorylation denotes phosphorylation
T15740 42967-42974 Entity denotes nuclear
T15741 42882-42893 Positive_regulation denotes attenuating
T15742 43031-43037 Protein denotes GATA-3
T15743 43065-43073 Protein denotes p38 MAPK
T15744 43221-43224 Protein denotes p38
T15745 43047-43061 Phosphorylation denotes phosphorylated
T15746 43335-43337 Protein denotes FP
T15747 43522-43531 Protein denotes IL-4 mRNA
T15748 43693-43697 Protein denotes IL-4
T15749 43508-43518 Gene_expression denotes expression
T15750 43698-43711 Transcription denotes transcription
T15751 43488-43494 Regulation denotes effect
T15752 43684-43692 Negative_regulation denotes suppress
T15753 43854-43860 Protein denotes GATA-3
T15754 43861-43871 Negative_regulation denotes inhibition
T15755 43929-43931 Protein denotes FP
T15756 44009-44015 Protein denotes GATA-3
T15757 43998-44008 Negative_regulation denotes inhibiting
T15758 44352-44356 Protein denotes IL-4
T15759 44361-44365 Protein denotes IL-5
T15760 44366-44373 Localization denotes release
T15761 44366-44373 Localization denotes release
T15762 44343-44351 Negative_regulation denotes suppress
T15763 44343-44351 Negative_regulation denotes suppress
T15764 44694-44704 Protein denotes importin-α
T15765 44764-44769 Protein denotes MKP-1
T15766 44786-44794 Protein denotes p38 MAPK
T15767 44835-44841 Protein denotes GATA-3
T15768 44889-44895 Protein denotes GATA-3
T15769 44611-44618 Entity denotes nuclear
T15770 44649-44656 Binding denotes binding
T15771 44751-44760 Gene_expression denotes synthesis
T15772 44777-44785 Negative_regulation denotes inhibits
T15773 44816-44831 Phosphorylation denotes phosphorylation
T15774 44864-44871 Entity denotes nuclear
T15775 44872-44885 Localization denotes translocation
T15776 44741-44750 Positive_regulation denotes increased
T15777 44801-44811 Negative_regulation denotes preventing
T15778 44850-44859 Positive_regulation denotes necessary
T15779 45117-45143 Protein denotes nasal Th2 cytokine release
T15780 45282-45292 Protein denotes importin-α
T15781 45265-45276 Binding denotes interaction
T15782 45236-45246 Negative_regulation denotes Prevention
T16703 24431-24434 Protein denotes CD3
T16704 24435-24439 Protein denotes CD28
T16705 24494-24500 Protein denotes GATA-3
T16706 24527-24534 Entity denotes nucleus
T16707 24477-24490 Localization denotes translocation
T16708 24554-24564 Protein denotes Histone H1
T16709 24569-24574 Protein denotes MEK-1
T16710 24782-24788 Protein denotes GATA-3
T16711 24800-24808 Protein denotes anti-CD3
T16712 24809-24813 Protein denotes CD28
T16713 24758-24765 Entity denotes nuclear
T16714 24766-24778 Localization denotes localization
T16715 24789-24796 Positive_regulation denotes induced
T16716 24749-24757 Negative_regulation denotes impaired
T16717 24985-24989 Protein denotes MEK1
T16718 24994-25004 Protein denotes histone H1
T16719 25232-25234 Protein denotes FP
T16720 25244-25248 Protein denotes IL-4
T16721 25253-25262 Protein denotes IL-5 mRNA
T16722 25277-25280 Protein denotes CD3
T16723 25281-25285 Protein denotes CD28
T16724 25263-25273 Gene_expression denotes expression
T16725 25263-25273 Gene_expression denotes expression
T16726 25235-25243 Negative_regulation denotes inhibits
T16727 25235-25243 Negative_regulation denotes inhibits
T16728 25306-25311 Protein denotes GAPDH
T16729 25517-25520 Protein denotes CD3
T16730 25521-25525 Protein denotes CD28
T16731 25581-25584 Protein denotes CD3
T16732 25585-25589 Protein denotes CD28
T16733 25601-25607 Protein denotes GATA-3
T16734 25637-25657 Protein denotes IL-5 promoter 60 min
T16735 25590-25600 Positive_regulation denotes stimulated
T16736 25611-25620 Binding denotes associate
T16737 25553-25560 Negative_regulation denotes reduces
T16738 25781-25786 Protein denotes ANOVA
T17504 26766-26772 Protein denotes GATA-3
T17505 26790-26800 Protein denotes importin-α
T17506 26805-26811 Protein denotes GATA-3
T17507 26773-26784 Binding denotes association
T17508 26812-26819 Entity denotes nuclear
T17509 26820-26826 Localization denotes import
T17510 26820-26826 Localization denotes import
T17511 26758-26765 Negative_regulation denotes reduces
T17512 26962-26964 Protein denotes FP
T17513 26975-26977 Protein denotes GR
T17514 26995-27005 Protein denotes importin-α
T17515 27007-27012 Protein denotes Imp-α
T17516 26978-26989 Binding denotes interaction
T17517 26978-26989 Binding denotes interaction
T17518 26978-26989 Binding denotes interaction
T17519 26965-26974 Positive_regulation denotes activated
T17520 26965-26974 Positive_regulation denotes activated
T17521 26965-26974 Positive_regulation denotes activated
T17522 26949-26958 Positive_regulation denotes induction
T17523 26949-26958 Positive_regulation denotes induction
T17524 26949-26958 Positive_regulation denotes induction
T17525 27038-27040 Protein denotes GR
T17526 27058-27066 Protein denotes importin
T17527 27041-27052 Binding denotes association
T17528 27026-27033 Regulation denotes control
T17529 27385-27387 Protein denotes FP
T17530 27398-27400 Protein denotes GR
T17531 27401-27408 Entity denotes nuclear
T17532 27409-27422 Localization denotes translocation
T17533 27388-27397 Positive_regulation denotes activated
T17534 27372-27381 Positive_regulation denotes induction
T17535 27654-27656 Protein denotes FP
T17536 27661-27669 Protein denotes anti-CD3
T17537 27670-27674 Protein denotes CD28
T17538 27741-27756 Protein denotes GATA-3–importin
T17539 27966-27970 Protein denotes αCD3
T17540 27971-27975 Protein denotes CD28
T17541 28009-28015 Protein denotes GATA-3
T17542 28094-28097 Protein denotes CD3
T17543 28098-28102 Protein denotes CD28
T17544 28020-28033 Gene_expression denotes overexpressed
T17545 28020-28033 Positive_regulation denotes overexpressed
T17546 28208-28213 Protein denotes ANOVA
T18168 29449-29463 Protein denotes p38 MAP kinase
T18169 29542-29548 Protein denotes GATA-3
T18170 29435-29445 Negative_regulation denotes inhibition
T18171 29464-29479 Phosphorylation denotes phosphorylation
T18172 29549-29555 Entity denotes serine
T18173 29556-29571 Phosphorylation denotes phosphorylation
T18174 29435-29445 Negative_regulation denotes inhibition
T18175 29523-29538 Negative_regulation denotes down-regulation
T18176 29705-29713 Protein denotes p38 MAPK
T18177 29717-29725 Protein denotes anti-CD3
T18178 29726-29730 Protein denotes CD28
T18179 29688-29700 Entity denotes tyrosine-182
T18180 29653-29668 Phosphorylation denotes phosphorylation
T18181 29640-29647 Negative_regulation denotes reduced
T18182 29881-29889 Protein denotes p38 MAPK
T18183 29807-29822 Phosphorylation denotes phosphorylation
T18184 29929-29937 Protein denotes p38 MAPK
T18185 29982-29990 Protein denotes anti-CD3
T18186 29991-29995 Protein denotes CD28
T18187 30053-30059 Protein denotes GATA-3
T18188 29915-29925 Negative_regulation denotes inhibition
T18189 30019-30025 Entity denotes serine
T18190 30043-30048 Entity denotes P-Ser
T18191 27966-27970 Protein denotes αCD3
T18192 27971-27975 Protein denotes CD28
T18636 31490-31497 Protein denotes phospho
T18637 31498-31504 Protein denotes GATA-3
T18638 31509-31519 Protein denotes importin-α
T18639 31652-31654 Protein denotes GR
T18640 31723-31729 Protein denotes GATA-3
T18641 31666-31673 Binding denotes binding
T18642 31713-31722 Positive_regulation denotes activated
T18643 31765-31767 Protein denotes GR
T18644 31755-31764 Positive_regulation denotes activated
T18645 31799-31802 Protein denotes CD3
T18646 31803-31807 Protein denotes CD28
T18647 31844-31846 Protein denotes GR
T18648 31914-31916 Protein denotes GR
T18649 31982-31985 Protein denotes CD3
T18650 31986-31990 Protein denotes CD28
T18651 31904-31913 Positive_regulation denotes Activated
T18652 32171-32186 Protein denotes GATA-3-importin
T18653 32187-32194 Binding denotes binding
T18654 32252-32254 Protein denotes GR
T18655 32273-32288 Protein denotes GATA-3–importin
T18656 32214-32223 Positive_regulation denotes activated
T18657 32453-32458 Protein denotes ANOVA
T19202 33471-33474 Protein denotes CD3
T19203 33475-33479 Protein denotes CD28
T19204 33498-33505 Entity denotes nuclear
T19205 33506-33518 Localization denotes localization
T19206 33506-33518 Localization denotes localization
T19207 33458-33465 Negative_regulation denotes prevent
T19208 33458-33465 Negative_regulation denotes prevent
T19209 33421-33427 Regulation denotes affect
T19210 33421-33427 Regulation denotes affect
T19211 25517-25520 Protein denotes CD3
T19212 25521-25525 Protein denotes CD28
T19213 33761-33767 Protein denotes GATA-3
T19214 33828-33836 Protein denotes anti-CD3
T19215 33837-33841 Protein denotes CD28
T19216 33771-33784 Gene_expression denotes overexpressed
T19217 33924-33932 Protein denotes anti-CD3
T19218 33933-33937 Protein denotes CD28
T19219 33991-33994 Protein denotes CD3
T19220 33995-33999 Protein denotes CD28
T19221 34011-34014 Protein denotes p65
T19222 34015-34022 Entity denotes nuclear
T19223 34023-34036 Localization denotes translocation
T19224 34023-34036 Localization denotes translocation
T19225 34023-34036 Localization denotes translocation
T19226 33978-33985 Negative_regulation denotes prevent
T19227 33978-33985 Negative_regulation denotes prevent
T19228 33978-33985 Negative_regulation denotes prevent
T19229 34231-34236 Protein denotes ANOVA
T19610 34844-34854 Protein denotes importin-α
T19611 34859-34865 Protein denotes GATA-3
T19612 34827-34838 Binding denotes interaction
T19613 34827-34838 Binding denotes interaction
T19614 34866-34873 Entity denotes nuclear
T19615 34874-34886 Localization denotes localization
T19616 34874-34886 Localization denotes localization
T19617 35007-35009 Protein denotes FP
T19618 35061-35067 Protein denotes GATA-3
T19619 35072-35082 Protein denotes importin-α
T19620 35041-35052 Binding denotes interaction
T19621 35442-35448 Protein denotes GATA-3
T19622 35453-35463 Protein denotes importin-α
T19623 35422-35433 Binding denotes association
T19624 35412-35421 Negative_regulation denotes decreased
T19625 35578-35588 Protein denotes importin-α
T19626 35632-35634 Protein denotes FP
T19627 35589-35599 Gene_expression denotes expression
T19628 35604-35614 Regulation denotes unaffected
T20308 38140-38142 Protein denotes GR
T20309 38147-38174 Protein denotes GATA-3 nuclear localisation
T20310 38180-38194 Protein denotes Nuclear GATA-3
T20311 38584-38590 Protein denotes GATA-3
T20312 38606-38624 Protein denotes cytoplasmic GATA-3
T20313 38656-38658 Protein denotes FP
T20314 38562-38569 Entity denotes nuclear
T20315 38570-38580 Gene_expression denotes expression
T20316 38625-38635 Gene_expression denotes expression
T20317 38642-38652 Negative_regulation denotes inhalation
T20318 38550-38558 Negative_regulation denotes decrease
T20319 38550-38558 Negative_regulation denotes decrease
T20320 38596-38605 Positive_regulation denotes increased
T20321 38761-38767 Protein denotes GATA-3
T20322 38837-38839 Protein denotes FP
T20323 38739-38746 Entity denotes nuclear
T20324 38747-38757 Gene_expression denotes expression
T20325 38727-38735 Negative_regulation denotes decrease
T20326 38841-38851 Protein denotes Histone H1
T20327 38856-38861 Protein denotes MEK-1
T20328 39296-39299 Protein denotes p38
T20329 39279-39291 Entity denotes tyrosine-182
T20330 39244-39259 Phosphorylation denotes phosphorylation
T20331 39227-39235 Negative_regulation denotes decrease
T10934 28557-28566 Negative_regulation denotes decreased
T10921 28290-28298 Protein denotes p38 MAPK
T10922 28374-28397 Protein denotes dual kinase phosphatase
T10923 28398-28403 Protein denotes MKP-1
T10924 28405-28409 Protein denotes MAPK
T10925 28357-28366 Positive_regulation denotes induction
T10926 28357-28366 Positive_regulation denotes induction
T10927 28281-28289 Negative_regulation denotes inhibits
T10928 28281-28289 Negative_regulation denotes inhibits
T10929 28525-28528 Protein denotes CD3
T10930 28529-28533 Protein denotes CD28
T10931 28567-28570 Protein denotes p38
T10932 28571-28575 Entity denotes MAPK
T10933 28576-28591 Phosphorylation denotes phosphorylation
T10935 28805-28811 Protein denotes GATA-3
T10936 28851-28854 Protein denotes CD3
T10937 28855-28859 Protein denotes CD28
T10938 28812-28818 Entity denotes serine
T10939 28819-28834 Phosphorylation denotes phosphorylation
T10940 28835-28842 Positive_regulation denotes induced
T10941 28797-28804 Negative_regulation denotes reduced
T10942 28954-28960 Protein denotes GATA-3
T18193 30298-30308 Protein denotes MKP-1 mRNA
T18194 30290-30297 Positive_regulation denotes induced
T18195 30489-30499 Protein denotes MKP-1 mRNA
T18196 30481-30488 Positive_regulation denotes induces
T18197 30624-30629 Protein denotes ANOVA
T4610 14381-14401 Protein denotes Th2 cytokine release
T4340 13500-13510 Protein denotes MAP kinase
T4341 13515-13528 Protein denotes phospho-ATF-2
T4342 13727-13730 Protein denotes IgG
T4608 14323-14331 Protein denotes anti-CD3
T4609 14332-14336 Protein denotes CD28
T4611 14371-14380 Positive_regulation denotes stimulate
T5189 15404-15421 Protein denotes complete protease
T5190 15431-15440 Negative_regulation denotes inhibitor
T5191 15633-15639 Protein denotes GATA-3
T5192 15643-15653 Protein denotes importin-α
T5193 15852-15863 Protein denotes anti-GATA-3
T5194 15865-15880 Protein denotes anti-importin-α
T5195 15882-15889 Protein denotes anti-GR
T5196 15891-15901 Protein denotes anti-p-p38
T5197 15902-15912 Protein denotes MAP kinase
T5198 15846-15851 Positive_regulation denotes using
T5460 16054-16063 Protein denotes Chromatin
T5461 16064-16083 Localization denotes Immunoprecipitation
T5462 16084-16093 Protein denotes Chromatin
T5463 16245-16261 Protein denotes immunoglobulin G
T5464 16391-16404 Protein denotes IL-5 promoter
T6261 18033-18038 Protein denotes NF-κB
T6262 18039-18049 Positive_regulation denotes Activation
T6263 18050-18055 Protein denotes NF-κB
T6264 18056-18063 Binding denotes binding
T6265 18261-18292 Protein denotes NF-κB consensus oligonucleotide
T6266 18335-18352 Protein denotes anti-p65 antibody
T6267 18401-18424 Protein denotes HRP-conjugated antibody
T6268 18363-18370 Binding denotes binding
T7345 21103-21111 Protein denotes anti-CD3
T7346 21112-21116 Protein denotes CD28
R752 T942 T945 themeOf mitogen-activated protein kinase,expression
R754 T943 T946 themeOf MAPK,expression
R755 T943 T948 themeOf MAPK,translocation
R756 T944 T947 themeOf p38 MAPK,inhibitor
R758 T945 T949 themeOf expression,induces
R759 T946 T950 themeOf expression,induces
R761 T948 T951 themeOf translocation,necessary
R764 T952 T954 themeOf GATA-3,effect
R765 T953 T955 themeOf Th2,expression
R767 T955 T956 themeOf expression,suppress
R3968 T4610 T4611 themeOf Th2 cytokine release,stimulate
R4481 T5189 T5190 themeOf complete protease,inhibitor
R4482 T5196 T5198 themeOf anti-p-p38,using
R4723 T5460 T5461 themeOf Chromatin,Immunoprecipitation
R5223 T6064 T6070 causeOf FITC swine anti-rabbit IgG,used
R5224 T6065 T6068 themeOf GATA-3,detection
R5225 T6067 T6069 themeOf GR,detection
R5226 T6068 T6070 themeOf detection,used
R5386 T6261 T6262 themeOf NF-κB,Activation
R5387 T6263 T6264 themeOf NF-κB,binding
R5388 T6267 T6268 themeOf HRP-conjugated antibody,binding
R6129 T7144 T7148 themeOf GATA-3,excised
R6130 T7145 T7149 themeOf pOTB7 using XhoI,excised
R7579 T8773 T8775 themeOf GATA-3 Nuclear Translocation,Effect
R7580 T8774 T8776 themeOf IL-4 mRNA,Effect
R7581 T8777 T8778 themeOf GATA-3-regulated IL-4 gene,expression
R7582 T8778 T8779 themeOf expression,inhibiting
R7583 T8780 T8784 themeOf anti-CD3,import
R7584 T8782 T8785 themeOf GATA-3,import
R7585 T8783 T8784 locationOf nuclear,import
R7586 T8783 T8785 locationOf nuclear,import
R7587 T8784 T8786 themeOf import,affect
R7588 T8785 T8787 themeOf import,affect
R7589 T8792 T8793 themeOf GATA-3,retention
R7590 T8793 T8794 themeOf retention,loss
R7633 T8849 T8861 causeOf CD28,stimulated
R7634 T8849 T8862 causeOf CD28,stimulated
R7635 T8850 T8854 themeOf IL-4,expression
R7636 T8851 T8855 themeOf IL-5 mRNA,expression
R7637 T8852 T8856 themeOf GATA-3,loss
R7638 T8852 T8857 themeOf GATA-3,binding
R7639 T8852 T8858 themeOf GATA-3,binding
R7640 T8853 T8858 themeOf IL-5 promoter,binding
R7641 T8854 T8859 themeOf expression,reductions
R7642 T8854 T8861 themeOf expression,stimulated
R7643 T8855 T8860 themeOf expression,reductions
R7644 T8855 T8862 themeOf expression,stimulated
R7645 T8857 T8863 themeOf binding,loss
R7646 T8858 T8864 themeOf binding,loss
R8047 T9334 T9337 themeOf GR,Ligand-Activated
R8048 T9338 T9341 themeOf GR,ligand-activated
R8049 T9339 T9342 themeOf GATA-3,ligand-activated
R8050 T9340 T9344 themeOf importin-α,import
R8051 T9343 T9344 locationOf nuclear,import
R8052 T9345 T9347 themeOf GR,interaction
R8053 T9346 T9347 themeOf importin-α,interaction
R8054 T9348 T9350 themeOf GR,translocation
R8055 T9349 T9350 locationOf nuclear,translocation
R8056 T9351 T9355 themeOf GATA-3,association
R8057 T9352 T9355 themeOf importin-α,association
R8058 T9355 T9356 themeOf association,decreased
R9378 T10922 T10925 themeOf dual kinase phosphatase,induction
R9379 T10923 T10926 themeOf MKP-1,induction
R9380 T10925 T10927 themeOf induction,inhibits
R9381 T10926 T10928 themeOf induction,inhibits
R9382 T10931 T10933 themeOf p38,phosphorylation
R9383 T10931 T10932 partOf p38,MAPK
R9384 T10932 T10933 Site MAPK,phosphorylation
R9385 T10933 T10934 themeOf phosphorylation,decreased
R9386 T10935 T10939 themeOf GATA-3,phosphorylation
R9387 T10935 T10938 partOf GATA-3,serine
R9388 T10938 T10939 Site serine,phosphorylation
R9389 T10939 T10940 themeOf phosphorylation,induced
R9390 T10939 T10941 themeOf phosphorylation,reduced
R9391 T10942 T10944 themeOf GATA-3,phosphorylation
R9392 T10944 T10945 themeOf phosphorylation,reduction
R9393 T10946 T10948 causeOf FP,induced
R9394 T10947 T10948 themeOf MKP-1 mRNA,induced
R9395 T10949 T10950 themeOf IL-4 mRNA,expression
R9396 T10950 T10951 themeOf expression,effects
R9397 T10952 T10957 themeOf GATA-3,activated
R9398 T10953 T10958 themeOf importin-α,activated
R9399 T10954 T10959 themeOf GR,activated
R9400 T10955 T10960 themeOf GR,activated
R9401 T10961 T10963 themeOf GATA-3,activated
R9402 T10964 T10966 themeOf GR,activated
R9403 T10964 T10967 themeOf GR,associate
R9404 T10965 T10968 themeOf GR,activated
R9405 T10969 T10970 themeOf GR,ligand-activated
R9406 T10971 T10972 themeOf FP,affect
R9407 T10974 T10975 themeOf FP,expression
R9408 T10974 T10976 causeOf FP,effect
R9409 T10975 T10976 themeOf expression,effect
R9410 T10977 T10982 themeOf FP,translocation
R9411 T10978 T10983 themeOf CD3,translocation
R9412 T10979 T10984 themeOf CD28,translocation
R9413 T10980 T10985 themeOf GR,activated
R9414 T10981 T10982 locationOf nuclear,translocation
R9415 T10981 T10983 locationOf nuclear,translocation
R9416 T10981 T10984 locationOf nuclear,translocation
R9417 T10986 T10989 themeOf p65,translocation
R9418 T10988 T10989 locationOf nuclear,translocation
R9419 T10989 T10990 themeOf translocation,effect
R11016 T12798 T12800 themeOf phospho-GATA-3,interaction
R11017 T12799 T12800 themeOf importin-α,interaction
R11018 T12800 T12801 themeOf interaction,decrease
R11019 T12802 T12808 causeOf M FP,suppresses
R11020 T12803 T12806 themeOf IL-4,expression
R11021 T12804 T12807 themeOf GATA-3,interaction
R11022 T12805 T12807 themeOf importin-α,interaction
R11023 T12806 T12808 themeOf expression,suppresses
R11024 T12807 T12809 themeOf interaction,attenuated
R11025 T12810 T12812 themeOf GATA-3–importin,interaction
R11026 T12811 T12812 themeOf α,interaction
R11027 T12812 T12813 themeOf interaction,reduced
R11028 T12815 T12818 themeOf GATA-3,interaction
R11029 T12817 T12819 themeOf importin-α,abundance
R11030 T12819 T12820 themeOf abundance,decrease
R11031 T12821 T12823 themeOf GATA-3,localization
R11032 T12822 T12823 locationOf cellular,localization
R11033 T12824 T12826 themeOf GR,translocation
R11034 T12825 T12826 locationOf nuclear,translocation
R11035 T12826 T12827 themeOf translocation,increased
R11036 T12828 T12831 themeOf cytoplasmic GATA-3,enhanced
R11037 T12829 T12831 causeOf FP,enhanced
R11038 T12832 T12833 themeOf p38 MAPK,phosphorylation
R11039 T12833 T12834 themeOf phosphorylation,inhibited
R11040 T12835 T12837 themeOf GATA-3,localization
R11041 T12836 T12837 locationOf nuclear,localization
R11042 T12837 T12838 themeOf localization,reduces
R11043 T12839 T12842 themeOf importin-α,competition
R11044 T12840 T12843 themeOf p38,phosphorylation
R11045 T12841 T12844 themeOf MKP-1,induction
R13478 T15647 T15648 themeOf Th2 genes,transcription
R13483 T15649 T15653 themeOf GR,compete
R13488 T15650 T15653 themeOf GATA-3,compete
R13489 T15650 T15654 themeOf GATA-3,activated
R13490 T15651 T15657 themeOf GATA-3,transport
R13491 T15652 T15658 themeOf GR,transport
R13492 T15656 T15657 locationOf nuclear,transport
R13493 T15656 T15658 locationOf nuclear,transport
R13494 T15725 T15727 themeOf MKP-1,induction
R13495 T15726 T15728 themeOf MAPK,inhibitor
R13496 T15657 T15659 themeOf transport,required
R13497 T15727 T15729 themeOf induction,modulate
R13498 T15728 T15730 themeOf inhibitor,induction
R13499 T15658 T15660 themeOf transport,required
R13500 T15731 T15733 themeOf MKP-1 mRNA,induction
R13501 T15661 T15667 themeOf MKP-1,expression
R13502 T15734 T15736 themeOf MKP-1,induction
R13503 T15662 T15668 themeOf p38 MAPK,inhibitor
R13504 T15735 T15738 themeOf p38 MAPK,attenuating
R13505 T15735 T15739 themeOf p38 MAPK,phosphorylation
R13506 T15736 T15738 causeOf induction,attenuating
R13507 T15736 T15741 causeOf induction,attenuating
R13508 T15664 T15669 themeOf p38 MAPK,activation
R13509 T15739 T15741 themeOf phosphorylation,attenuating
R13510 T15665 T15670 themeOf GATA-3,phosphorylation
R13511 T15742 T15745 themeOf GATA-3,phosphorylated
R13512 T15665 T15677 causeOf GATA-3,necessary
R13513 T15666 T15671 themeOf importin-α,interaction
R13514 T15747 T15749 themeOf IL-4 mRNA,expression
R13515 T15748 T15750 themeOf IL-4,transcription
R13516 T15666 T15673 themeOf importin-α,import
R13517 T15749 T15751 themeOf expression,effect
R13518 T15667 T15674 themeOf expression,increase
R13519 T15750 T15752 themeOf transcription,suppress
R13520 T15669 T15675 themeOf activation,prevent
R13521 T15753 T15754 themeOf GATA-3,inhibition
R13522 T15756 T15757 themeOf GATA-3,inhibiting
R13523 T15670 T15676 themeOf phosphorylation,prevent
R13524 T15758 T15760 themeOf IL-4,release
R13525 T15759 T15761 themeOf IL-5,release
R13526 T15671 T15677 themeOf interaction,necessary
R13527 T15760 T15762 themeOf release,suppress
R13528 T15761 T15763 themeOf release,suppress
R13529 T15672 T15673 locationOf nuclear,import
R13530 T15764 T15770 themeOf importin-α,binding
R13531 T15765 T15771 themeOf MKP-1,synthesis
R13532 T15678 T15682 themeOf GATA-3,translocation
R13533 T15766 T15772 themeOf p38 MAPK,inhibits
R13534 T15767 T15773 themeOf GATA-3,phosphorylation
R13535 T15767 T15778 causeOf GATA-3,necessary
R13536 T15768 T15775 themeOf GATA-3,translocation
R13537 T15771 T15776 themeOf synthesis,increased
R13538 T15773 T15777 themeOf phosphorylation,preventing
R13539 T15774 T15775 locationOf nuclear,translocation
R13540 T15775 T15778 themeOf translocation,necessary
R13541 T15679 T15681 themeOf nuclear transporter protein importin-α,interacts
R13542 T15780 T15781 themeOf importin-α,interaction
R13543 T15781 T15782 themeOf interaction,Prevention
R13544 T15680 T15682 locationOf nucleus,translocation
R13545 T15683 T15688 themeOf GATA-3,knockdown
R13546 T15687 T15689 themeOf GATA-3,transcription
R13547 T15692 T15695 themeOf importin-α,binding
R13548 T15692 T15696 themeOf importin-α,binding
R13549 T15693 T15696 themeOf GR,binding
R13550 T15693 T15697 themeOf GR,activated
R13551 T15694 T15700 themeOf Th2 gene,transcription
R13554 T15695 T15698 themeOf binding,activated
R13556 T15696 T15699 themeOf binding,activated
R13557 T15700 T15701 themeOf transcription,switch
R13561 T15700 T15702 themeOf transcription,switch
R13563 T15704 T15707 themeOf p65 subunit,translocation
R13567 T15705 T15708 themeOf NF-κB,translocation
R13571 T15706 T15707 locationOf nuclear,translocation
R13574 T15706 T15708 locationOf nuclear,translocation
R13575 T15707 T15709 themeOf translocation,affected
R13582 T15708 T15710 themeOf translocation,affected
R13586 T15712 T15715 themeOf GATA-3,exclusion
R13595 T15713 T15716 themeOf GATA-3,degradation
R13599 T15714 T15715 locationOf nuclear,exclusion
R13605 T15716 T15717 themeOf degradation,induces
R13608 T15718 T15719 themeOf GR,activated
R13615 T15720 T15721 themeOf importin-α,associate
R13617 T15722 T15723 themeOf MKP-1,induction
R14335 T16705 T16707 themeOf GATA-3,translocation
R14336 T16706 T16707 locationOf nucleus,translocation
R14337 T16710 T16714 themeOf GATA-3,localization
R14338 T16713 T16714 locationOf nuclear,localization
R14339 T16714 T16715 themeOf localization,induced
R14340 T16714 T16716 themeOf localization,impaired
R14341 T16719 T16726 causeOf FP,inhibits
R14342 T16719 T16727 causeOf FP,inhibits
R14343 T16720 T16724 themeOf IL-4,expression
R14344 T16721 T16725 themeOf IL-5 mRNA,expression
R14345 T16724 T16726 themeOf expression,inhibits
R14346 T16725 T16727 themeOf expression,inhibits
R14347 T16732 T16735 causeOf CD28,stimulated
R14348 T16733 T16735 themeOf GATA-3,stimulated
R14349 T16733 T16736 themeOf GATA-3,associate
R14350 T16734 T16736 themeOf IL-5 promoter 60 min,associate
R14351 T16735 T16737 themeOf stimulated,reduces
R15022 T17504 T17507 themeOf GATA-3,association
R15023 T17505 T17507 themeOf importin-α,association
R15024 T17505 T17509 themeOf importin-α,import
R15025 T17506 T17510 themeOf GATA-3,import
R15026 T17507 T17511 themeOf association,reduces
R15027 T17508 T17509 locationOf nuclear,import
R15028 T17508 T17510 locationOf nuclear,import
R15029 T17512 T17519 causeOf FP,activated
R15030 T17512 T17520 causeOf FP,activated
R15031 T17512 T17521 causeOf FP,activated
R15032 T17513 T17516 themeOf GR,interaction
R15033 T17513 T17517 themeOf GR,interaction
R15034 T17513 T17518 themeOf GR,interaction
R15035 T17514 T17517 themeOf importin-α,interaction
R15036 T17515 T17518 themeOf Imp-α,interaction
R15037 T17516 T17519 themeOf interaction,activated
R15038 T17517 T17520 themeOf interaction,activated
R15039 T17518 T17521 themeOf interaction,activated
R15040 T17519 T17522 themeOf activated,induction
R15041 T17520 T17523 themeOf activated,induction
R15042 T17521 T17524 themeOf activated,induction
R15043 T17525 T17527 themeOf GR,association
R15044 T17526 T17527 themeOf importin,association
R15045 T17527 T17528 themeOf association,control
R15046 T17529 T17533 causeOf FP,activated
R15047 T17530 T17532 themeOf GR,translocation
R15048 T17531 T17532 locationOf nuclear,translocation
R15049 T17532 T17533 themeOf translocation,activated
R15050 T17533 T17534 themeOf activated,induction
R15051 T17541 T17544 themeOf GATA-3,overexpressed
R15052 T17544 T17545 themeOf overexpressed,overexpressed
R15571 T18168 T18170 themeOf p38 MAP kinase,inhibition
R15572 T18168 T18171 themeOf p38 MAP kinase,phosphorylation
R15573 T18169 T18173 themeOf GATA-3,phosphorylation
R15574 T18169 T18172 partOf GATA-3,serine
R15575 T18171 T18174 themeOf phosphorylation,inhibition
R15576 T18172 T18173 Site serine,phosphorylation
R15577 T18173 T18175 themeOf phosphorylation,down-regulation
R15578 T18176 T18180 themeOf p38 MAPK,phosphorylation
R15579 T18176 T18179 partOf p38 MAPK,tyrosine-182
R15580 T18179 T18180 Site tyrosine-182,phosphorylation
R15581 T18180 T18181 themeOf phosphorylation,reduced
R15582 T18182 T18183 themeOf p38 MAPK,phosphorylation
R15583 T18184 T18188 themeOf p38 MAPK,inhibition
R15584 T18185 T18189 partOf anti-CD3,serine
R15585 T18186 T18189 partOf CD28,serine
R15586 T18187 T18189 partOf GATA-3,serine
R15587 T18187 T18190 partOf GATA-3,P-Ser
R15588 T18193 T18194 themeOf MKP-1 mRNA,induced
R15589 T18195 T18196 themeOf MKP-1 mRNA,induces
R15928 T18639 T18641 themeOf GR,binding
R15929 T18640 T18642 themeOf GATA-3,activated
R15930 T18643 T18644 themeOf GR,activated
R15931 T18648 T18651 themeOf GR,Activated
R15932 T18652 T18653 themeOf GATA-3-importin,binding
R15933 T18654 T18656 themeOf GR,activated
R16400 T19202 T19205 themeOf CD3,localization
R16401 T19203 T19206 themeOf CD28,localization
R16402 T19204 T19205 locationOf nuclear,localization
R16403 T19204 T19206 locationOf nuclear,localization
R16404 T19205 T19207 themeOf localization,prevent
R16405 T19206 T19208 themeOf localization,prevent
R16406 T19207 T19209 themeOf prevent,affect
R16407 T19208 T19210 themeOf prevent,affect
R16408 T19213 T19216 themeOf GATA-3,overexpressed
R16409 T19219 T19223 themeOf CD3,translocation
R16410 T19220 T19224 themeOf CD28,translocation
R16411 T19221 T19225 themeOf p65,translocation
R16412 T19222 T19223 locationOf nuclear,translocation
R16413 T19222 T19224 locationOf nuclear,translocation
R16414 T19222 T19225 locationOf nuclear,translocation
R16415 T19223 T19226 themeOf translocation,prevent
R16416 T19224 T19227 themeOf translocation,prevent
R16417 T19225 T19228 themeOf translocation,prevent
R16754 T19610 T19612 themeOf importin-α,interaction
R16755 T19610 T19613 themeOf importin-α,interaction
R16756 T19610 T19615 themeOf importin-α,localization
R16757 T19611 T19613 themeOf GATA-3,interaction
R16758 T19611 T19616 themeOf GATA-3,localization
R16759 T19614 T19615 locationOf nuclear,localization
R16760 T19614 T19616 locationOf nuclear,localization
R16761 T19618 T19620 themeOf GATA-3,interaction
R16762 T19619 T19620 themeOf importin-α,interaction
R16763 T19621 T19623 themeOf GATA-3,association
R16764 T19622 T19623 themeOf importin-α,association
R16765 T19623 T19624 themeOf association,decreased
R16766 T19625 T19627 themeOf importin-α,expression
R16767 T19626 T19628 causeOf FP,unaffected
R16768 T19627 T19628 themeOf expression,unaffected
R17370 T20311 T20315 themeOf GATA-3,expression
R17371 T20312 T20316 themeOf cytoplasmic GATA-3,expression
R17372 T20313 T20317 themeOf FP,inhalation
R17373 T20315 T20318 themeOf expression,decrease
R17374 T20316 T20319 themeOf expression,decrease
R17375 T20316 T20320 themeOf expression,increased
R17376 T20317 T20318 causeOf inhalation,decrease
R17377 T20317 T20319 causeOf inhalation,decrease
R17378 T20321 T20324 themeOf GATA-3,expression
R17379 T20324 T20325 themeOf expression,decrease
R17380 T20328 T20330 themeOf p38,phosphorylation
R17381 T20328 T20329 partOf p38,tyrosine-182
R17382 T20329 T20330 Site tyrosine-182,phosphorylation
R17383 T20330 T20331 themeOf phosphorylation,decrease
R734 T919 T920 themeOf GATA-3 Nuclear Import,Suppression
R735 T919 T921 themeOf GATA-3 Nuclear Import,Phosphorylation
R737 T921 T922 themeOf Phosphorylation,Suppression
R739 T923 T926 causeOf GATA-3,regulating
R740 T924 T925 themeOf "interleukin (IL)-4, IL-5",expression
R742 T925 T926 themeOf expression,regulating
R743 T927 T928 themeOf GATA-3,effects
R744 T929 T930 themeOf GATA-3,regulation
R745 T930 T931 themeOf regulation,effect
R746 T934 T939 themeOf GATA-3,translocation
R747 T937 T940 themeOf glucocorticoid receptor,ligand-activated
R748 T938 T939 locationOf nuclear,translocation
R750 T939 T941 themeOf translocation,inhibits

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T96 498-508 Regulation denotes regulating
T97 498-508 Regulation denotes regulating
T98 498-508 Regulation denotes regulating
T99 513-523 Gene_expression denotes expression
T100 513-523 Gene_expression denotes expression
T101 513-523 Gene_expression denotes expression
T102 541-559 Protein denotes interleukin (IL)-4
T103 561-565 Protein denotes IL-5
T104 571-576 Protein denotes IL-13
T105 755-761 Protein denotes GATA-3
T106 795-801 Regulation denotes effect
T107 850-856 Protein denotes GATA-3
T108 857-867 Regulation denotes regulation
T109 1090-1098 Negative_regulation denotes inhibits
T110 1099-1106 Entity denotes nuclear
T111 1107-1120 Localization denotes translocation
T112 1124-1130 Protein denotes GATA-3
T113 1236-1247 Negative_regulation denotes competition
T114 1236-1247 Negative_regulation denotes competition
T115 1256-1262 Protein denotes GATA-3
T116 1278-1287 Positive_regulation denotes activated
T117 1288-1311 Protein denotes glucocorticoid receptor
T118 1316-1323 Entity denotes nuclear
T119 1324-1333 Localization denotes transport
T120 1324-1333 Localization denotes transport
T121 1400-1407 Positive_regulation denotes induces
T122 1412-1422 Gene_expression denotes expression
T123 1426-1479 Protein denotes mitogen-activated protein kinase (MAPK) phosphatase-1
T124 1481-1486 Protein denotes MKP-1
T125 1536-1545 Positive_regulation denotes necessary
T126 1550-1556 Protein denotes GATA-3
T127 1557-1564 Entity denotes nuclear
T128 1565-1578 Localization denotes translocation
T129 1700-1708 Negative_regulation denotes inhibits
T130 1709-1715 Protein denotes GATA-3
T131 1716-1723 Entity denotes nuclear
T132 1724-1737 Localization denotes translocation
T133 1846-1863 Negative_regulation denotes inhibitory effect
T134 1867-1873 Protein denotes GATA-3
T1201 8286-8289 Protein denotes CD4
T1202 8318-8327 Negative_regulation denotes knockdown
T1203 8331-8337 Protein denotes GATA-3
T1204 8338-8348 Gene_expression denotes expression
T1205 8463-8469 Protein denotes GATA-3
T1206 8507-8518 Localization denotes translocate
T1207 8547-8554 Entity denotes nucleus
T1208 8558-8564 Binding denotes access
T1209 8569-8575 Binding denotes target
T1210 8592-8599 Entity denotes nuclear
T1211 8600-8610 Localization denotes expression
T1212 8614-8620 Protein denotes GATA-3
T1213 8621-8630 Positive_regulation denotes following
T1214 8748-8757 Positive_regulation denotes following
T1215 8808-8814 Protein denotes GATA-3
T1216 8870-8881 Localization denotes transported
T1217 8891-8898 Entity denotes nucleus
T1218 9014-9020 Protein denotes GATA-3
T1219 9304-9308 Regulation denotes role
T1220 9312-9327 Phosphorylation denotes phosphorylating
T1221 9328-9334 Protein denotes GATA-3
T1222 9338-9345 Positive_regulation denotes enhance
T1223 9350-9361 Binding denotes interaction
T1224 9652-9659 Binding denotes binding
T1225 9663-9687 Protein denotes glucocorticoid receptors
T1226 9689-9692 Protein denotes GRs
T1227 9706-9717 Localization denotes translocate
T1228 9725-9732 Entity denotes nucleus
T1229 9744-9752 Binding denotes interact
T1256 10795-10803 Positive_regulation denotes requires
T1257 10946-10948 Protein denotes GR
T1258 10949-10955 Localization denotes import
T1259 10998-11007 Regulation denotes important
T1260 11016-11026 Regulation denotes regulation
T1261 11030-11032 Protein denotes GR
T1262 11033-11043 Positive_regulation denotes activation
T1263 11366-11370 Protein denotes IL-4
T1264 11372-11376 Protein denotes IL-5
T1265 11382-11387 Protein denotes IL-13
T1266 11455-11464 Regulation denotes regulated
T1267 11455-11464 Regulation denotes regulated
T1268 11455-11464 Regulation denotes regulated
T1269 11525-11528 Protein denotes CAT
T1270 11590-11592 Protein denotes GR
T1271 11593-11600 Negative_regulation denotes reduced
T1272 11593-11600 Negative_regulation denotes reduced
T1273 11601-11607 Protein denotes GATA-3
T1274 11608-11616 Positive_regulation denotes mediated
T1275 11608-11616 Positive_regulation denotes mediated
T1276 11617-11621 Protein denotes IL-5
T1277 11626-11629 Protein denotes -13
T1278 11639-11647 Gene_expression denotes activity
T1279 11639-11647 Gene_expression denotes activity
T1280 11657-11660 Protein denotes CD4
T1281 11705-11716 Localization denotes recruitment
T1282 11720-11722 Protein denotes GR
T1283 11727-11732 Regulation denotes alter true
T1284 11748-11754 Protein denotes GATA-3
T1285 11765-11769 Binding denotes bind
T1286 11928-11935 Regulation denotes effects true
T1287 11928-11935 Regulation denotes effects true
T1288 11974-11980 Protein denotes GATA-3
T1289 11981-11996 Phosphorylation denotes phosphorylation
T1290 12001-12008 Entity denotes nuclear
T1291 12009-12022 Localization denotes translocation
T1292 12179-12186 Regulation denotes effects
T1293 12221-12227 Protein denotes GATA-3
T1294 12240-12252 Localization denotes localization
T3970 13206-13209 Protein denotes CD3
T3971 13211-13215 Protein denotes CD28
T3972 13217-13219 Protein denotes GR
T3973 13329-13335 Protein denotes GATA-3
T3974 13347-13349 Protein denotes GR
T3975 13523-13528 Protein denotes ATF-2
T8186 23176-23182 Regulation denotes Effect
T8187 23205-23211 Protein denotes GATA-3
T8188 23212-23219 Entity denotes Nuclear
T8189 23220-23233 Localization denotes Translocation
T8190 23238-23242 Protein denotes IL-4
T8191 23268-23277 Regulation denotes effective
T8192 23281-23291 Negative_regulation denotes inhibiting
T8193 23292-23298 Protein denotes GATA-3
T8194 23299-23308 Regulation denotes regulated
T8195 23309-23313 Protein denotes IL-4
T8196 23319-23329 Gene_expression denotes expression
T8197 23407-23413 Regulation denotes affect true
T8198 23428-23438 Positive_regulation denotes stimulated
T8199 23439-23446 Entity denotes nuclear
T8200 23447-23453 Localization denotes import
T8201 23457-23463 Protein denotes GATA-3
T8202 23505-23513 Positive_regulation denotes resulted
T8203 23537-23544 Entity denotes nuclear
T8204 23545-23551 Protein denotes GATA-3
T8205 23552-23565 Localization denotes translocation
T8206 23720-23725 Protein denotes MEK-1
T8207 23784-23790 Positive_regulation denotes caused
T8208 23784-23790 Positive_regulation denotes caused
T8209 23801-23805 Negative_regulation denotes loss
T8210 23809-23816 Entity denotes nuclear
T8211 23817-23823 Protein denotes GATA-3
T8212 23824-23834 Localization denotes expression
T8213 23839-23850 Entity denotes cytoplasmic
T8214 23851-23860 Localization denotes retention
T8215 23864-23870 Protein denotes GATA-3
T8216 23959-23970 Regulation denotes This effect
T8217 23959-23970 Regulation denotes This effect
T8218 23959-23970 Regulation denotes This effect
T8219 23999-24008 Regulation denotes dependent
T8220 23999-24008 Regulation denotes dependent
T8221 23999-24008 Regulation denotes dependent
T8222 24101-24111 Regulation denotes associated
T8223 24101-24111 Regulation denotes associated
T8224 24101-24111 Regulation denotes associated
T8225 24124-24134 Negative_regulation denotes reductions
T8226 24124-24134 Negative_regulation denotes reductions
T8227 24152-24162 Positive_regulation denotes stimulated
T8228 24152-24162 Positive_regulation denotes stimulated
T8229 24163-24167 Protein denotes IL-4
T8230 24172-24176 Protein denotes IL-5
T8231 24177-24192 Transcription denotes mRNA expression
T8232 24177-24192 Transcription denotes mRNA expression
T8233 24211-24215 Negative_regulation denotes loss
T8234 24219-24225 Protein denotes GATA-3
T8235 24226-24233 Binding denotes binding
T8236 24248-24252 Protein denotes IL-5
T8237 24253-24261 Entity denotes promoter
T8929 26335-26344 Negative_regulation denotes decreased
T8930 26349-26360 Binding denotes association
T8931 26369-26375 Protein denotes GATA-3
T8932 26391-26398 Positive_regulation denotes induced
T8933 26447-26456 Regulation denotes dependent
T8934 26496-26515 Protein denotes GFP-labelled GATA-3
T8935 26561-26567 Protein denotes GATA-3
T8936 26568-26575 Entity denotes nuclear
T8937 26576-26582 Localization denotes import
T8938 26583-26592 Positive_regulation denotes following
T8939 26634-26644 Negative_regulation denotes attenuated
T9602 29069-29073 Transcription denotes mRNA
T9603 29108-29117 Regulation denotes dependent
T9604 29201-29208 Regulation denotes effects
T9605 29201-29208 Regulation denotes effects
T9606 29201-29208 Regulation denotes effects
T9607 29218-29224 Protein denotes GATA-3
T9608 29225-29232 Entity denotes nuclear
T9609 29233-29239 Localization denotes import
T9610 29252-29263 Binding denotes association
T9611 29268-29272 Protein denotes IL-4
T9612 29273-29288 Transcription denotes mRNA expression
T9613 30686-30697 Negative_regulation denotes competition
T9614 30686-30697 Negative_regulation denotes competition
T9615 30735-30744 Positive_regulation denotes activated
T9616 30745-30751 Protein denotes GATA-3
T9617 30769-30778 Positive_regulation denotes activated
T9618 30779-30781 Protein denotes GR
T9619 30804-30813 Positive_regulation denotes activated
T9633 31075-31077 Protein denotes GR
T9634 31090-31096 Protein denotes GATA-3
T9635 31110-31119 Binding denotes associate
T9636 31110-31119 Binding denotes associate
T9637 31157-31166 Positive_regulation denotes activated
T9638 31167-31169 Protein denotes GR
T9639 31170-31180 Negative_regulation denotes attenuates
T9640 31185-31192 Phosphorylation denotes phospho
T9641 31193-31199 Protein denotes GATA-3
T9642 31211-31222 Binding denotes interaction
T9643 31242-31251 Regulation denotes dependent
T9644 31308-31317 Positive_regulation denotes activated
T9645 31318-31320 Protein denotes GR
T9646 31325-31332 Negative_regulation denotes compete true
T9647 31346-31352 Protein denotes GATA-3
T9648 31353-31356 Binding denotes for
T9649 31380-31385 Negative_regulation denotes limit
T9650 31386-31392 Protein denotes GATA-3
T9651 31393-31400 Entity denotes nuclear
T9652 31401-31407 Localization denotes import
T9653 32560-32566 Regulation denotes effect
T9654 32560-32566 Regulation denotes effect
T9655 32576-32582 Protein denotes GATA-3
T9656 32583-32590 Entity denotes nuclear
T9657 32591-32597 Localization denotes export
T9658 32605-32616 Protein_catabolism denotes degradation
T9659 32671-32677 Regulation denotes affect true
T9660 32699-32704 Negative_regulation denotes block
T9661 32705-32711 Protein denotes GATA-3
T9662 32712-32719 Entity denotes nuclear
T9663 32720-32732 Localization denotes localization
T9664 32770-32776 Regulation denotes effect true
T9665 32791-32797 Protein denotes GATA-3
T9666 32798-32808 Gene_expression denotes expression
T9667 32939-32945 Regulation denotes affect true
T9668 32946-32952 Protein denotes GATA-3
T9669 32953-32960 Entity denotes nuclear
T9670 32961-32970 Localization denotes residency
T9671 33000-33009 Positive_regulation denotes activated
T9672 33010-33012 Protein denotes GR
T9673 33022-33029 Positive_regulation denotes enhance true
T9674 33030-33036 Protein denotes GATA-3
T9675 33037-33044 Entity denotes nuclear
T9676 33045-33051 Localization denotes export
T9677 33066-33072 Regulation denotes effect
T9678 33082-33088 Protein denotes GATA-3
T9679 33089-33096 Entity denotes nuclear
T9680 33097-33103 Localization denotes import
T9681 33150-33156 Regulation denotes effect true
T9682 33160-33163 Protein denotes p65
T9683 33164-33171 Entity denotes nuclear
T9684 33172-33185 Localization denotes translocation
T11235 35753-35763 Negative_regulation denotes suppresses
T11236 35753-35763 Negative_regulation denotes suppresses
T11237 35764-35768 Protein denotes IL-4
T11238 35773-35775 Protein denotes -5
T11239 35781-35791 Gene_expression denotes expression
T11240 35781-35791 Gene_expression denotes expression
T11241 35796-35806 Negative_regulation denotes attenuated
T11242 35811-35822 Binding denotes interaction
T11243 35826-35832 Protein denotes GATA-3
T11244 36078-36085 Negative_regulation denotes reduced
T11245 36086-36092 Protein denotes GATA-3
T11246 36104-36115 Binding denotes interaction
T11247 36134-36143 Regulation denotes dependent
T11248 36157-36165 Regulation denotes produced
T11249 36173-36181 Negative_regulation denotes decrease
T11250 36185-36191 Protein denotes GATA-3
T11251 36203-36214 Binding denotes association
T11252 36483-36489 Protein denotes GATA-3
T11253 36501-36512 Binding denotes association
T11254 36599-36609 Negative_regulation denotes attenuated
T11255 36610-36621 Binding denotes interaction
T11256 36625-36631 Protein denotes GATA-3
T11257 36847-36853 Regulation denotes affect true
T11258 36863-36875 Localization denotes localization
T11259 36879-36885 Protein denotes GATA-3
T11260 36972-36981 Positive_regulation denotes increased
T11261 36982-36984 Protein denotes GR
T11262 36985-36992 Entity denotes nuclear
T11263 36993-37006 Localization denotes translocation
T11264 37069-37075 Protein denotes GATA-3
T11265 37424-37431 Positive_regulation denotes induced
T11266 37444-37448 Localization denotes loss true
T11267 37452-37459 Entity denotes nuclear
T11268 37460-37466 Protein denotes GATA-3
T11269 37591-37602 Entity denotes cytoplasmic
T11270 37603-37609 Protein denotes GATA-3
T11271 37610-37616 Localization denotes levels
T11272 37622-37630 Positive_regulation denotes enhanced
T13173 40280-40289 Localization denotes transport
T13174 40298-40304 Protein denotes GATA-3
T13175 40309-40311 Protein denotes GR
T13176 40364-40372 Positive_regulation denotes increase
T13177 40377-40387 Gene_expression denotes expression
T13178 40391-40396 Protein denotes MKP-1
T13179 40512-40519 Negative_regulation denotes prevent
T13180 40524-40539 Phosphorylation denotes phosphorylation
T13181 40543-40549 Protein denotes GATA-3
T13182 40558-40567 Positive_regulation denotes necessary
T13183 40558-40567 Positive_regulation denotes necessary
T13184 40572-40583 Binding denotes interaction
T13185 40604-40614 Positive_regulation denotes subsequent
T13186 40615-40622 Entity denotes nuclear
T13187 40623-40629 Localization denotes import
T13188 40661-40674 Localization denotes translocation
T13189 40678-40684 Protein denotes GATA-3
T13190 40711-40718 Entity denotes nucleus
T13191 40719-40727 Regulation denotes involves
T13192 40778-40787 Binding denotes interacts
T13193 40793-40807 Phosphorylation denotes phosphorylated
T13194 40808-40814 Protein denotes GATA-3
T13195 40859-40865 Protein denotes GATA-3
T13196 40866-40875 Gene_expression denotes knockdown true
T13197 40899-40910 Negative_regulation denotes suppression
T13198 40899-40910 Negative_regulation denotes suppression
T13199 40928-40938 Positive_regulation denotes stimulated
T13200 40928-40938 Positive_regulation denotes stimulated
T13201 40939-40943 Protein denotes IL-4
T13202 40944-40948 Protein denotes IL-5
T13203 40954-40963 Transcription denotes induction
T13204 40954-40963 Transcription denotes induction
T13205 40995-40999 Regulation denotes role
T13206 40995-40999 Regulation denotes role
T13207 41004-41010 Protein denotes GATA-3
T13208 41018-41031 Transcription denotes transcription
T13209 41018-41031 Transcription denotes transcription
T13210 41092-41094 Protein denotes GR
T13211 41114-41121 Entity denotes nuclear
T13212 41122-41128 Localization denotes import
T13213 41142-41148 Protein denotes GATA-3
T13214 41190-41201 Negative_regulation denotes competition true
T13215 41227-41229 Protein denotes GR
T13216 41234-41241 Phosphorylation denotes phospho
T13217 41242-41248 Protein denotes GATA-3
T13218 41253-41260 Entity denotes nuclear
T13219 41261-41267 Localization denotes import
T13220 41323-41330 Binding denotes binding
T13221 41323-41330 Binding denotes binding
T13222 41348-41357 Positive_regulation denotes activated
T13223 41358-41360 Protein denotes GR
T13224 41366-41373 Phosphorylation denotes phospho
T13225 41374-41380 Protein denotes GATA-3
T13226 41427-41433 Negative_regulation denotes reduce true
T13227 41434-41440 Protein denotes GATA-3
T13228 41441-41446 Localization denotes entry
T13229 41597-41603 Protein denotes GATA-3
T13230 41608-41615 Entity denotes nuclear
T13231 41616-41629 Localization denotes translocation
T13232 41637-41640 Protein denotes p65
T13233 41666-41674 Regulation denotes affected true
T13234 41747-41758 Negative_regulation denotes this effect
T13235 41768-41774 Protein denotes GATA-3
T13236 41775-41782 Entity denotes nuclear
T13237 41783-41792 Localization denotes exclusion
T13238 41827-41835 Positive_regulation denotes enhances true
T13239 41836-41842 Protein denotes GATA-3
T13240 41843-41850 Entity denotes nuclear
T13241 41851-41857 Localization denotes export
T13242 41870-41877 Positive_regulation denotes induces true
T13243 41878-41884 Protein denotes GATA-3
T13244 41885-41896 Protein_catabolism denotes degradation
T13245 41985-41994 Positive_regulation denotes activated
T13246 41995-41997 Protein denotes GR
T13247 42010-42019 Negative_regulation denotes attenuate
T13248 42029-42036 Phosphorylation denotes phospho
T13249 42037-42043 Protein denotes GATA-3
T13250 42055-42066 Binding denotes association
T13251 42142-42149 Phosphorylation denotes phospho
T13252 42150-42156 Protein denotes GATA-3
T13253 42161-42170 Binding denotes associate
T13254 42368-42378 Positive_regulation denotes contribute true
T13255 42386-42395 Negative_regulation denotes reduction
T13256 42399-42405 Protein denotes GATA-3
T13257 42406-42413 Entity denotes nuclear
T13258 42414-42420 Localization denotes import
T13259 42442-42446 Regulation denotes role true
T13260 42521-42526 Protein denotes MKP-1
T13261 42527-42536 Gene_expression denotes induction
T13262 42597-42606 Positive_regulation denotes induction
T13263 42610-42615 Protein denotes MKP-1
T13264 42698-42707 Gene_expression denotes induction
T13265 42711-42716 Protein denotes MKP-1
T13266 42722-42731 Positive_regulation denotes following
T13267 42827-42836 Gene_expression denotes induction
T13268 42840-42845 Protein denotes MKP-1
T13269 42850-42856 Negative_regulation denotes reduce
T13270 42857-42863 Protein denotes GATA-3
T13271 42864-42871 Entity denotes nuclear
T13272 42872-42878 Localization denotes import
T13273 42882-42893 Negative_regulation denotes attenuating
T13274 42916-42926 Regulation denotes subsequent
T13275 42927-42933 Protein denotes GATA-3
T13276 42934-42949 Phosphorylation denotes phosphorylation
T13277 42956-42966 Negative_regulation denotes preventing true
T13278 42967-42974 Entity denotes nuclear
T13279 42975-42988 Localization denotes translocation
T13280 43010-43024 Entity denotes serine residue
T13281 43031-43037 Protein denotes GATA-3
T13282 43047-43061 Phosphorylation denotes phosphorylated
T13283 43296-43306 Negative_regulation denotes impairment
T13284 43310-43316 Protein denotes GATA-3
T13285 43317-43324 Entity denotes nuclear
T13286 43325-43331 Localization denotes import
T13287 43477-43494 Negative_regulation denotes inhibitory effect true true
T13288 43508-43518 Transcription denotes expression
T13289 43522-43526 Protein denotes IL-4
T13290 43684-43692 Negative_regulation denotes suppress
T13291 43693-43697 Protein denotes IL-4
T13292 43698-43711 Transcription denotes transcription
T13293 43854-43860 Protein denotes GATA-3
T13294 43861-43871 Negative_regulation denotes inhibition
T13295 43998-44008 Negative_regulation denotes inhibiting
T13296 44009-44015 Protein denotes GATA-3
T13297 44343-44351 Negative_regulation denotes suppress
T13298 44343-44351 Negative_regulation denotes suppress
T13299 44352-44356 Protein denotes IL-4
T13300 44361-44365 Protein denotes IL-5
T13301 44366-44373 Localization denotes release
T13302 44366-44373 Localization denotes release
T13303 44583-44600 Negative_regulation denotes inhibitory effect
T13304 44583-44600 Negative_regulation denotes inhibitory effect
T13305 44604-44610 Protein denotes GATA-3
T13306 44611-44618 Entity denotes nuclear
T13307 44619-44632 Localization denotes translocation
T13308 44649-44656 Binding denotes binding
T13309 44741-44750 Positive_regulation denotes increased
T13310 44751-44760 Gene_expression denotes synthesis
T13311 44764-44769 Protein denotes MKP-1
T13312 44801-44811 Negative_regulation denotes preventing
T13313 44816-44831 Phosphorylation denotes phosphorylation
T13314 44835-44841 Protein denotes GATA-3
T13315 44850-44859 Positive_regulation denotes necessary
T13316 44864-44871 Entity denotes nuclear
T13317 44872-44885 Localization denotes translocation
T13318 44889-44895 Protein denotes GATA-3
T13319 45236-45246 Negative_regulation denotes Prevention
T13320 45250-45257 Phosphorylation denotes phospho
T13321 45258-45264 Protein denotes GATA-3
T16000 24390-24398 Negative_regulation denotes inhibits
T16001 24399-24405 Protein denotes GATA-3
T16002 24406-24413 Entity denotes nuclear
T16003 24414-24420 Localization denotes import
T16004 24477-24490 Localization denotes translocation
T16005 24494-24500 Protein denotes GATA-3
T16006 24527-24534 Entity denotes nucleus
T16007 24569-24574 Protein denotes MEK-1
T16008 24758-24765 Entity denotes nuclear
T16009 24766-24778 Localization denotes localization
T16010 24782-24788 Protein denotes GATA-3
T16011 24789-24796 Positive_regulation denotes induced
T16012 24985-24989 Protein denotes MEK1
T16013 25235-25243 Negative_regulation denotes inhibits
T16014 25235-25243 Negative_regulation denotes inhibits
T16015 25244-25248 Protein denotes IL-4
T16016 25253-25257 Protein denotes IL-5
T16017 25258-25273 Transcription denotes mRNA expression
T16018 25258-25273 Transcription denotes mRNA expression
T16019 25277-25280 Protein denotes CD3
T16020 25281-25285 Protein denotes CD28
T16021 25286-25298 Regulation denotes costimulated
T16022 25286-25298 Regulation denotes costimulated
T16023 25553-25560 Negative_regulation denotes reduces
T16024 25590-25600 Positive_regulation denotes stimulated
T16025 25601-25607 Protein denotes GATA-3
T16026 25611-25620 Binding denotes associate
T16027 25637-25641 Protein denotes IL-5
T16028 25642-25650 Entity denotes promoter
T17583 29498-29508 Regulation denotes associated
T17584 29523-29538 Negative_regulation denotes down-regulation
T17585 29542-29548 Protein denotes GATA-3
T17586 29549-29555 Entity denotes serine
T17587 29556-29571 Phosphorylation denotes phosphorylation
T17588 29782-29788 Regulation denotes effect
T17589 29807-29822 Phosphorylation denotes phosphorylation
T17590 29826-29858 Protein denotes activated transcription factor 2
T17591 29860-29865 Protein denotes ATF-2
T17592 29970-29978 Negative_regulation denotes decrease
T17593 30011-30018 Positive_regulation denotes induced
T17594 30019-30025 Entity denotes serine
T17595 30026-30041 Phosphorylation denotes phosphorylation
T17596 30053-30059 Protein denotes GATA-3
T17597 30290-30297 Positive_regulation denotes induced
T17598 30298-30303 Protein denotes MKP-1
T17599 30328-30337 Regulation denotes dependent
T17600 30481-30488 Positive_regulation denotes induces
T17601 30489-30494 Protein denotes MKP-1
T17602 30510-30519 Regulation denotes dependent
T18278 31490-31497 Phosphorylation denotes phospho
T18279 31498-31504 Protein denotes GATA-3
T18280 31597-31599 Protein denotes GR
T18281 31643-31651 Positive_regulation denotes enhances
T18282 31652-31654 Protein denotes GR
T18283 31666-31673 Binding denotes binding
T18284 31723-31729 Protein denotes GATA-3
T18285 31755-31764 Positive_regulation denotes activated
T18286 31765-31767 Protein denotes GR
T18287 31773-31779 Protein denotes GATA-3
T18288 31834-31843 Negative_regulation denotes attenuate true
T18289 31844-31846 Protein denotes GR
T18290 31858-31869 Binding denotes association
T18291 31904-31913 Positive_regulation denotes Activated
T18292 31914-31916 Protein denotes GR
T18293 31917-31923 Negative_regulation denotes blocks
T18294 31948-31955 Phosphorylation denotes phospho
T18295 31956-31962 Protein denotes GATA-3
T18296 32008-32019 Binding denotes interacting
T18297 32098-32104 Protein denotes GATA-3
T18298 32160-32170 Positive_regulation denotes stimulated
T18299 32171-32177 Protein denotes GATA-3
T18300 32187-32194 Binding denotes binding
T18301 32214-32223 Positive_regulation denotes activated
T18302 32235-32247 Positive_regulation denotes unstimulated true
T18303 32252-32254 Protein denotes GR
T18304 32258-32269 Negative_regulation denotes attenuation
T18305 32273-32279 Protein denotes GATA-3
T18306 32291-32302 Binding denotes association
T18307 32321-32330 Regulation denotes dependent
T18706 33723-33734 Protein_catabolism denotes degradation
T18707 33761-33767 Protein denotes GATA-3
T18708 33978-33985 Negative_regulation denotes prevent true
T18709 34000-34010 Positive_regulation denotes stimulated
T18710 34011-34014 Protein denotes p65
T18711 34015-34022 Entity denotes nuclear
T18712 34023-34036 Localization denotes translocation
T19698 38007-38014 Negative_regulation denotes impairs
T19699 38015-38021 Protein denotes GATA-3
T19700 38022-38029 Entity denotes nuclear
T19701 38030-38042 Localization denotes localization
T19702 38140-38142 Protein denotes GR
T19703 38147-38153 Protein denotes GATA-3
T19704 38154-38161 Entity denotes nuclear
T19705 38162-38174 Localization denotes localisation
T19706 38162-38174 Localization denotes localisation
T19707 38188-38194 Protein denotes GATA-3
T19708 38540-38549 Regulation denotes dependent
T19709 38540-38549 Regulation denotes dependent
T19710 38550-38558 Negative_regulation denotes decrease
T19711 38562-38569 Entity denotes nuclear
T19712 38570-38580 Localization denotes expression
T19713 38584-38590 Protein denotes GATA-3
T19714 38596-38605 Positive_regulation denotes increased
T19715 38606-38617 Entity denotes cytoplasmic
T19716 38618-38624 Protein denotes GATA-3
T19717 38625-38635 Localization denotes expression
T19718 38727-38735 Negative_regulation denotes decrease
T19719 38739-38746 Entity denotes nuclear
T19720 38747-38757 Localization denotes expression
T19721 38761-38767 Protein denotes GATA-3
T19722 38783-38794 Entity denotes cytoplasmic
T19723 38795-38801 Protein denotes GATA-3
T19724 38802-38812 Localization denotes expression
T19725 38856-38861 Protein denotes MEK-1
T13160 40017-40023 Protein denotes GATA-3
T13161 40157-40166 Positive_regulation denotes activated
T13162 40167-40169 Protein denotes GR
T13163 40181-40188 Negative_regulation denotes compete
T13164 40194-40203 Positive_regulation denotes activated
T13165 40204-40210 Protein denotes GATA-3
T13166 40215-40222 Entity denotes nuclear
T13167 40223-40229 Localization denotes import
T13168 40230-40233 Regulation denotes via
T13169 40255-40263 Regulation denotes required
T13170 40255-40263 Regulation denotes required
T13171 40272-40279 Entity denotes nuclear
T13172 40280-40289 Localization denotes transport
T13322 45265-45276 Binding denotes interaction
T5481 16679-16681 Protein denotes GR
T5482 16682-16688 Protein denotes GATA-3
T5483 16938-16944 Protein denotes GATA-3
T5484 17044-17046 Protein denotes GR
T5485 17315-17321 Protein denotes GATA-3
T5486 17422-17424 Protein denotes GR
T5487 17819-17825 Protein denotes GATA-3
T5488 17927-17929 Protein denotes GR
T7351 21208-21218 Gene_expression denotes expressing
T7352 21219-21229 Protein denotes GATA-3-GFP
T4614 14968-14972 Protein denotes IL-4
T8185 23176-23182 Regulation denotes Effect
T6272 18846-18848 Protein denotes GR
T18695 33294-33300 Regulation denotes affect true
T18696 33301-33307 Protein denotes GATA-3
T18697 33316-33322 Localization denotes export
T18698 33421-33427 Regulation denotes affect true
T18699 33458-33465 Negative_regulation denotes prevent
T18700 33480-33490 Positive_regulation denotes stimulated
T18701 33491-33497 Protein denotes GATA-3
T18702 33498-33505 Entity denotes nuclear
T18703 33506-33518 Localization denotes localization
T18704 33698-33704 Regulation denotes affect true
T18705 33716-33722 Protein denotes GATA-3
T11224 34273-34283 Negative_regulation denotes Inhibitory
T11225 34313-34319 Protein denotes GATA-3
T11226 34320-34327 Entity denotes Nuclear
T11227 34328-34340 Localization denotes Localization
T11228 34441-34450 Regulation denotes dependent
T11229 34451-34459 Negative_regulation denotes decrease
T11230 34474-34485 Binding denotes interaction
T11231 34494-34501 Phosphorylation denotes phospho
T11232 34502-34508 Protein denotes GATA-3
T11233 34603-34612 Negative_regulation denotes inhibited
T11234 34681-34691 Negative_regulation denotes attenuated
T11273 37655-37664 Regulation denotes dependent
T11274 39467-39474 Negative_regulation denotes reduces
T11275 39475-39482 Entity denotes nuclear
T11276 39483-39495 Localization denotes localization
T11277 39499-39505 Protein denotes GATA-3
T11278 39525-39535 Negative_regulation denotes inhibiting
T11279 39544-39550 Protein denotes GATA-3
T11280 39560-39571 Binding denotes association
T11281 39698-39706 Positive_regulation denotes mediated
T11282 39707-39713 Protein denotes GATA-3
T11283 39714-39729 Phosphorylation denotes phosphorylation
T11284 39740-39749 Gene_expression denotes induction
T11285 39753-39758 Protein denotes MKP-1
T11286 39801-39808 Regulation denotes effects
T11287 39832-39843 Negative_regulation denotes suppression
T11288 39847-39853 Protein denotes GATA-3
T11289 39854-39861 Entity denotes nuclear
T11290 39862-39868 Localization denotes import
T6761 19780-19786 Protein denotes GATA-3
T6762 19787-19790 Protein denotes GFP
T6763 19805-19811 Protein denotes GATA-3
T6764 19923-19929 Protein denotes GATA-3
T6765 19951-19957 Protein denotes GATA-3
T6766 19987-19991 Protein denotes XhoI
T6767 20075-20080 Protein denotes BamHI
T6768 20161-20167 Protein denotes GATA-3
T6769 20427-20433 Protein denotes GATA-3
T6770 20451-20454 Protein denotes GFP
T6771 20494-20499 Protein denotes EcoRI
T6772 20533-20539 Protein denotes GATA-3
T6773 20595-20598 Protein denotes GFP
T89 0-11 Negative_regulation denotes Suppression
T90 0-11 Negative_regulation denotes Suppression
T91 15-21 Protein denotes GATA-3
T92 22-29 Entity denotes Nuclear
T93 30-36 Localization denotes Import
T94 41-56 Phosphorylation denotes Phosphorylation
T95 466-472 Protein denotes GATA-3
T6073 18143-18146 Protein denotes p65
T4347 14481-14487 Protein denotes GATA-3
T4348 14488-14500 Localization denotes localization
T5201 16391-16395 Protein denotes IL-5
T8914 25841-25843 Protein denotes GR
T8915 25858-25864 Protein denotes GATA-3
T8916 25865-25868 Binding denotes for
T8917 25945-25954 Positive_regulation denotes activated
T8918 25955-25957 Protein denotes GR
T8919 25969-25975 Protein denotes GATA-3
T8920 25976-25980 Positive_regulation denotes uses
T8921 25976-25980 Positive_regulation denotes uses
T8922 26000-26007 Entity denotes nuclear
T8923 26008-26014 Localization denotes import
T8924 26008-26014 Localization denotes import
T8925 26060-26062 Protein denotes GR
T8926 26173-26175 Protein denotes GR
T8927 26176-26183 Entity denotes nuclear
T8928 26184-26197 Localization denotes translocation
T1181 7372-7390 Protein denotes interleukin (IL)-4
T1182 7392-7396 Protein denotes IL-5
T1183 7402-7407 Protein denotes IL-13
T1184 7437-7441 Protein denotes IL-4
T1185 7446-7451 Protein denotes IL-13
T1186 7511-7515 Protein denotes IL-5
T1187 7635-7641 Protein denotes GATA-3
T1188 7666-7675 Gene_expression denotes expressed
T1189 7698-7704 Protein denotes GATA-3
T1190 7757-7766 Positive_regulation denotes activates
T1191 7757-7766 Positive_regulation denotes activates
T1192 7757-7766 Positive_regulation denotes activates
T1193 7771-7780 Entity denotes promoters
T1194 7784-7788 Protein denotes IL-4
T1195 7790-7794 Protein denotes IL-5
T1196 7800-7805 Protein denotes IL-13
T1197 7861-7867 Protein denotes GATA-3
T1198 8023-8029 Protein denotes GATA-3
T1199 8088-8094 Protein denotes GATA-3
T1200 8146-8151 Protein denotes Gata3
T1230 9865-9874 Positive_regulation denotes activated
T1231 9875-9877 Protein denotes GR
T1232 9878-9887 Binding denotes interacts
T1233 10076-10087 Binding denotes recruitment
T1234 10122-10143 Protein denotes histone deacetylase-2
T1235 10155-10162 Entity denotes Nuclear
T1236 10163-10175 Localization denotes localisation
T1237 10180-10189 Localization denotes retention
T1238 10193-10195 Protein denotes GR
T1239 10199-10207 Positive_regulation denotes mediated
T1240 10199-10207 Positive_regulation denotes mediated
T1241 10311-10318 Regulation denotes control
T1242 10322-10329 Entity denotes nuclear
T1243 10330-10336 Localization denotes export
T1244 10343-10375 Protein denotes chromosomal region maintenance 1
T1245 10377-10382 Protein denotes CRM-1
T1246 10384-10393 Regulation denotes dependent
T1247 10408-10411 Entity denotes NL1
T1248 10447-10452 Binding denotes binds
T1249 10673-10682 Regulation denotes resulting
T1250 10683-10685 Protein denotes GR
T1251 10692-10704 Localization denotes translocates
T1252 10712-10719 Entity denotes nucleus
T1253 10720-10734 Positive_regulation denotes in response to
T1254 10752-10763 Binding denotes interaction
T1255 10769-10779 Protein denotes importin 7
T9583 28261-28266 Protein denotes MKP-1
T9584 28357-28366 Gene_expression denotes induction
T9585 28398-28403 Protein denotes MKP-1
T9586 28405-28423 Protein denotes MAPK phosphatase-1
T9587 28557-28566 Negative_regulation denotes decreased
T9588 28629-28644 Phosphorylation denotes phosphorylation
T9589 28663-28669 Binding denotes target
T9590 28670-28675 Protein denotes ATF-2
T9591 28797-28804 Negative_regulation denotes reduced
T9592 28805-28811 Protein denotes GATA-3
T9593 28812-28818 Entity denotes serine
T9594 28819-28834 Phosphorylation denotes phosphorylation
T9595 28835-28842 Positive_regulation denotes induced
T9596 28906-28915 Regulation denotes dependent
T9597 28936-28950 Negative_regulation denotes This reduction
T9598 28954-28960 Protein denotes GATA-3
T9599 28961-28976 Phosphorylation denotes phosphorylation
T9600 29055-29062 Positive_regulation denotes induced
T9601 29063-29068 Protein denotes MKP-1
T9620 30814-30816 Protein denotes GR
T9621 30831-30840 Positive_regulation denotes increased
T9622 30841-30843 Protein denotes GR
T9623 30855-30866 Binding denotes association
T9624 30867-30897 Regulation denotes in the presence and absence of true
T9625 30898-30907 Positive_regulation denotes activated
T9626 30908-30914 Protein denotes GATA-3
T9627 30961-30970 Positive_regulation denotes activated
T9628 30971-30977 Protein denotes GATA-3
T9629 30986-30991 Negative_regulation denotes block true
T9630 30992-30994 Protein denotes GR
T9631 31006-31017 Binding denotes association
T9632 31065-31074 Positive_regulation denotes activated
T4845 15633-15639 Protein denotes GATA-3
T16789 26758-26765 Negative_regulation denotes reduces
T16790 26758-26765 Negative_regulation denotes reduces
T16791 26766-26772 Protein denotes GATA-3
T16792 26773-26784 Binding denotes association
T16793 26805-26811 Protein denotes GATA-3
T16794 26812-26819 Entity denotes nuclear
T16795 26820-26826 Localization denotes import
T16796 26939-26948 Regulation denotes dependent
T16797 26949-26958 Positive_regulation denotes induction
T16798 26965-26974 Positive_regulation denotes activated
T16799 26975-26977 Protein denotes GR
T16800 26978-26989 Binding denotes interaction
T16801 27038-27040 Protein denotes GR
T16802 27041-27052 Binding denotes association
T16803 27362-27371 Regulation denotes dependent
T16804 27372-27381 Positive_regulation denotes induction
T16805 27388-27397 Positive_regulation denotes activated
T16806 27398-27400 Protein denotes GR
T16807 27401-27408 Entity denotes nuclear
T16808 27409-27422 Localization denotes translocation
T16809 27719-27728 Regulation denotes dependent
T16810 27729-27737 Negative_regulation denotes decrease
T16811 27741-27747 Protein denotes GATA-3
T16812 27759-27770 Binding denotes association
T16813 28009-28015 Protein denotes GATA-3
T16814 28020-28033 Gene_expression denotes overexpressed
T19273 34812-34819 Negative_regulation denotes impairs
T19274 34812-34819 Negative_regulation denotes impairs
T19275 34820-34826 Protein denotes GATA-3
T19276 34827-34838 Binding denotes interaction
T19277 34859-34865 Protein denotes GATA-3
T19278 34866-34873 Entity denotes nuclear
T19279 34874-34886 Localization denotes localization
T19280 35032-35040 Negative_regulation denotes impaired
T19281 35041-35052 Binding denotes interaction
T19282 35061-35067 Protein denotes GATA-3
T19283 35412-35421 Negative_regulation denotes decreased
T19284 35422-35433 Binding denotes association
T19285 35442-35448 Protein denotes GATA-3
R970 T1204 T1202 themeOf expression,knockdown
R971 T1205 T1206 themeOf GATA-3,translocate
R972 T1205 T1208 themeOf GATA-3,access
R973 T1205 T1209 themeOf GATA-3,target
R974 T1207 T1206 locationOf nucleus,translocate
R975 T1210 T1211 locationOf nuclear,expression
R976 T1211 T1213 themeOf expression,following
R977 T1211 T1214 themeOf expression,following
R978 T1212 T1211 themeOf GATA-3,expression
R979 T1215 T1216 themeOf GATA-3,transported
R980 T1217 T1216 locationOf nucleus,transported
R981 T1220 T1219 themeOf phosphorylating,role
R982 T1220 T1222 causeOf phosphorylating,enhance
R983 T1221 T1220 themeOf GATA-3,phosphorylating
R984 T1221 T1223 themeOf GATA-3,interaction
R985 T1223 T1222 themeOf interaction,enhance
R986 T1225 T1224 themeOf glucocorticoid receptors,binding
R987 T1225 T1227 themeOf glucocorticoid receptors,translocate
R988 T1225 T1229 themeOf glucocorticoid receptors,interact
R989 T1226 T1225 equivalentTo GRs,glucocorticoid receptors
R990 T1228 T1227 locationOf nucleus,translocate
R991 T1231 T1230 themeOf GR,activated
R992 T1231 T1232 themeOf GR,interacts
R993 T1231 T1233 themeOf GR,recruitment
R994 T1234 T1233 themeOf histone deacetylase-2,recruitment
R995 T1235 T1236 locationOf Nuclear,localisation
R996 T1236 T1240 themeOf localisation,mediated
R997 T1237 T1239 themeOf retention,mediated
R998 T1238 T1236 themeOf GR,localisation
R999 T1238 T1237 themeOf GR,retention
R1000 T1238 T1243 themeOf GR,export
R1001 T1241 T1240 causeOf control,mediated
R1002 T1241 T1239 causeOf control,mediated
R1003 T1241 T1246 themeOf control,dependent
R1004 T1242 T1243 locationOf nuclear,export
R1005 T1243 T1241 themeOf export,control
R1006 T1244 T1246 causeOf chromosomal region maintenance 1,dependent
R1007 T1245 T1244 equivalentTo CRM-1,chromosomal region maintenance 1
R1008 T1247 T1248 themeOf NL1,binds
R1009 T1247 T1238 partOf NL1,GR
R1010 T1250 T1251 themeOf GR,translocates
R1011 T1250 T1254 themeOf GR,interaction
R1012 T1251 T1249 themeOf translocates,resulting
R1013 T1251 T1253 themeOf translocates,in response to
R1014 T1252 T1251 locationOf nucleus,translocates
R1015 T1254 T1253 causeOf interaction,in response to
R1016 T1254 T1256 themeOf interaction,requires
R1017 T1255 T1254 themeOf importin 7,interaction
R1018 T1257 T1258 themeOf GR,import
R1019 T1260 T1259 themeOf regulation,important
R1020 T1261 T1262 themeOf GR,activation
R1021 T1262 T1260 themeOf activation,regulation
R1022 T1263 T1266 themeOf IL-4,regulated
R1023 T1264 T1268 themeOf IL-5,regulated
R1024 T1265 T1267 themeOf IL-13,regulated
R1025 T1270 T1271 causeOf GR,reduced
R1026 T1270 T1272 causeOf GR,reduced
R1027 T1273 T1274 causeOf GATA-3,mediated
R1028 T1273 T1275 causeOf GATA-3,mediated
R1029 T1274 T1271 themeOf mediated,reduced
R1030 T1275 T1272 themeOf mediated,reduced
R1031 T1276 T1278 themeOf IL-5,activity
R1032 T1277 T1279 themeOf -13,activity
R1033 T1278 T1274 themeOf activity,mediated
R1034 T1279 T1275 themeOf activity,mediated
R1035 T1281 T1283 causeOf recruitment,alter
R1036 T1282 T1281 themeOf GR,recruitment
R1037 T1284 T1285 themeOf GATA-3,bind
R1038 T1285 T1283 themeOf bind,alter
R1039 T1288 T1289 themeOf GATA-3,phosphorylation
R1040 T1288 T1291 themeOf GATA-3,translocation
R1041 T1289 T1287 themeOf phosphorylation,effects
R1042 T1290 T1291 locationOf nuclear,translocation
R1043 T1291 T1286 themeOf translocation,effects
R1044 T1293 T1294 themeOf GATA-3,localization
R1045 T1294 T1292 themeOf localization,effects
R7090 T8205 T8202 themeOf translocation,resulted
R7091 T8209 T8208 themeOf loss,caused
R7092 T8210 T8212 locationOf nuclear,expression
R7093 T8211 T8212 themeOf GATA-3,expression
R7094 T8212 T8209 themeOf expression,loss
R7095 T8213 T8214 locationOf cytoplasmic,retention
R7096 T8214 T8207 themeOf retention,caused
R7097 T8215 T8214 themeOf GATA-3,retention
R7098 T8216 T8221 themeOf This effect,dependent
R7099 T8217 T8220 themeOf This effect,dependent
R7100 T8218 T8219 themeOf This effect,dependent
R7101 T8222 T8217 themeOf associated,This effect
R7102 T8223 T8218 themeOf associated,This effect
R7103 T8224 T8216 themeOf associated,This effect
R7104 T8225 T8224 themeOf reductions,associated
R7105 T8226 T8222 themeOf reductions,associated
R7106 T8227 T8225 themeOf stimulated,reductions
R7107 T8228 T8226 themeOf stimulated,reductions
R7108 T8229 T8232 themeOf IL-4,mRNA expression
R7109 T8230 T8231 themeOf IL-5,mRNA expression
R7110 T8231 T8228 themeOf mRNA expression,stimulated
R7111 T8232 T8227 themeOf mRNA expression,stimulated
R7112 T8233 T8223 themeOf loss,associated
R7113 T8234 T8235 themeOf GATA-3,binding
R7114 T8235 T8233 themeOf binding,loss
R7115 T8237 T8235 themeOf promoter,binding
R7116 T8237 T8236 partOf promoter,IL-5
R7695 T8930 T8932 themeOf association,induced
R7696 T8931 T8930 themeOf GATA-3,association
R7697 T8935 T8937 themeOf GATA-3,import
R7698 T8936 T8937 locationOf nuclear,import
R7699 T8937 T8938 themeOf import,following
R7700 T8937 T8939 themeOf import,attenuated
R8282 T9651 T9652 locationOf nuclear,import
R8283 T9652 T9649 themeOf import,limit
R8284 T9655 T9657 themeOf GATA-3,export
R8285 T9655 T9658 themeOf GATA-3,degradation
R8286 T9656 T9657 locationOf nuclear,export
R8287 T9657 T9653 themeOf export,effect
R8288 T9658 T9654 themeOf degradation,effect
R8289 T9660 T9659 themeOf block,affect
R8290 T9661 T9663 themeOf GATA-3,localization
R8291 T9662 T9663 locationOf nuclear,localization
R8292 T9663 T9660 themeOf localization,block
R8293 T9665 T9666 themeOf GATA-3,expression
R8294 T9666 T9664 themeOf expression,effect
R8295 T9668 T9670 themeOf GATA-3,residency
R8296 T9669 T9670 locationOf nuclear,residency
R8297 T9670 T9667 themeOf residency,affect
R8298 T9672 T9671 themeOf GR,activated
R8299 T9672 T9673 causeOf GR,enhance
R8300 T9674 T9676 themeOf GATA-3,export
R8301 T9675 T9676 locationOf nuclear,export
R8302 T9676 T9673 themeOf export,enhance
R8303 T9678 T9680 themeOf GATA-3,import
R8304 T9679 T9680 locationOf nuclear,import
R8305 T9680 T9677 themeOf import,effect
R8306 T9682 T9684 themeOf p65,translocation
R8307 T9683 T9684 locationOf nuclear,translocation
R8308 T9684 T9681 themeOf translocation,effect
R9623 T11262 T11263 locationOf nuclear,translocation
R9624 T11263 T11260 themeOf translocation,increased
R9625 T11266 T11265 themeOf loss,induced
R9626 T11267 T11266 locationOf nuclear,loss
R9627 T11268 T11266 themeOf GATA-3,loss
R9628 T11269 T11271 locationOf cytoplasmic,levels
R9629 T11270 T11271 themeOf GATA-3,levels
R9630 T11271 T11272 themeOf levels,enhanced
R9631 T11272 T11273 themeOf enhanced,dependent
R9632 T11275 T11276 locationOf nuclear,localization
R9633 T11276 T11274 themeOf localization,reduces
R9634 T11277 T11276 themeOf GATA-3,localization
R9635 T11278 T11274 causeOf inhibiting,reduces
R9636 T11279 T11280 themeOf GATA-3,association
R9637 T11280 T11278 themeOf association,inhibiting
R9638 T11282 T11283 themeOf GATA-3,phosphorylation
R9639 T11283 T11281 themeOf phosphorylation,mediated
R9640 T11285 T11284 themeOf MKP-1,induction
R9641 T11287 T11286 themeOf suppression,effects
R9642 T11288 T11290 themeOf GATA-3,import
R9643 T11289 T11290 locationOf nuclear,import
R9644 T11290 T11287 themeOf import,suppression
R11287 T13162 T13161 themeOf GR,activated
R11288 T13162 T13163 causeOf GR,compete
R11289 T13165 T13163 themeOf GATA-3,compete
R11294 T13171 T13173 locationOf nuclear,transport
R11295 T13171 T13172 locationOf nuclear,transport
R11296 T13172 T13169 themeOf transport,required
R11297 T13173 T13170 themeOf transport,required
R11298 T13174 T13173 themeOf GATA-3,transport
R11299 T13175 T13172 themeOf GR,transport
R11300 T13177 T13176 themeOf expression,increase
R11301 T13178 T13177 themeOf MKP-1,expression
R11302 T13180 T13179 themeOf phosphorylation,prevent
R11303 T13180 T13182 causeOf phosphorylation,necessary
R11304 T13180 T13183 causeOf phosphorylation,necessary
R11305 T13181 T13180 themeOf GATA-3,phosphorylation
R11306 T13181 T13184 themeOf GATA-3,interaction
R11307 T13181 T13187 themeOf GATA-3,import
R11308 T13184 T13182 themeOf interaction,necessary
R11309 T13184 T13185 causeOf interaction,subsequent
R11310 T13186 T13187 locationOf nuclear,import
R11311 T13187 T13183 themeOf import,necessary
R11312 T13187 T13185 themeOf import,subsequent
R11313 T13188 T13191 themeOf translocation,involves
R11314 T13189 T13188 themeOf GATA-3,translocation
R11315 T13190 T13188 locationOf nucleus,translocation
R11316 T13194 T13192 themeOf GATA-3,interacts
R11317 T13194 T13193 themeOf GATA-3,phosphorylated
R11318 T13195 T13196 themeOf GATA-3,knockdown
R11319 T13196 T13197 causeOf knockdown,suppression
R11320 T13196 T13198 causeOf knockdown,suppression
R11321 T13199 T13198 themeOf stimulated,suppression
R11322 T13200 T13197 themeOf stimulated,suppression
R11323 T13201 T13203 themeOf IL-4,induction
R11324 T13201 T13209 themeOf IL-4,transcription
R11325 T13202 T13204 themeOf IL-5,induction
R11326 T13202 T13208 themeOf IL-5,transcription
R11327 T13203 T13200 themeOf induction,stimulated
R11328 T13204 T13199 themeOf induction,stimulated
R11329 T13207 T13206 causeOf GATA-3,role
R11330 T13207 T13205 causeOf GATA-3,role
R11331 T13208 T13205 themeOf transcription,role
R11332 T13209 T13206 themeOf transcription,role
R11333 T13210 T13212 themeOf GR,import
R11334 T13211 T13212 locationOf nuclear,import
R11335 T13215 T13214 causeOf GR,competition
R11336 T13217 T13219 themeOf GATA-3,import
R11337 T13217 T13216 themeOf GATA-3,phospho
R11338 T13218 T13219 locationOf nuclear,import
R11339 T13219 T13214 themeOf import,competition
R11340 T13223 T13220 themeOf GR,binding
R11341 T13223 T13222 themeOf GR,activated
R11342 T13225 T13221 themeOf GATA-3,binding
R11343 T13225 T13224 themeOf GATA-3,phospho
R11344 T13227 T13228 themeOf GATA-3,entry
R11345 T13228 T13226 themeOf entry,reduce
R11346 T13230 T13231 locationOf nuclear,translocation
R11347 T13231 T13233 themeOf translocation,affected
R11348 T13232 T13231 themeOf p65,translocation
R11349 T13235 T13237 themeOf GATA-3,exclusion
R11350 T13236 T13237 locationOf nuclear,exclusion
R11351 T13237 T13234 themeOf exclusion,this effect
R11352 T13239 T13241 themeOf GATA-3,export
R11354 T13241 T13238 themeOf export,enhances
R11367 T13258 T13255 themeOf import,reduction
R11368 T13260 T13261 themeOf MKP-1,induction
R11369 T13261 T13259 themeOf induction,role
R11370 T13263 T13262 themeOf MKP-1,induction
R11371 T13264 T13266 themeOf induction,following
R11372 T13265 T13264 themeOf MKP-1,induction
R11373 T13267 T13273 causeOf induction,attenuating
R11374 T13268 T13267 themeOf MKP-1,induction
R11376 T13270 T13272 themeOf GATA-3,import
R11377 T13271 T13272 locationOf nuclear,import
R11378 T13272 T13269 themeOf import,reduce
R11380 T13273 T13269 causeOf attenuating,reduce
R11381 T13274 T13273 themeOf subsequent,attenuating
R11382 T13275 T13276 themeOf GATA-3,phosphorylation
R11383 T13276 T13274 themeOf phosphorylation,subsequent
R11401 T13305 T13307 themeOf GATA-3,translocation
R11402 T13305 T13308 themeOf GATA-3,binding
R11403 T13306 T13307 locationOf nuclear,translocation
R11404 T13307 T13304 themeOf translocation,inhibitory effect
R11405 T13307 T13303 themeOf translocation,inhibitory effect
R11406 T13308 T13304 causeOf binding,inhibitory effect
R11407 T13309 T13303 causeOf increased,inhibitory effect
R11408 T13309 T13312 causeOf increased,preventing
R11409 T13310 T13309 themeOf synthesis,increased
R11410 T13311 T13310 themeOf MKP-1,synthesis
R11411 T13313 T13312 themeOf phosphorylation,preventing
R11412 T13314 T13313 themeOf GATA-3,phosphorylation
R11413 T13316 T13317 locationOf nuclear,translocation
R11414 T13317 T13315 themeOf translocation,necessary
R11415 T13318 T13317 themeOf GATA-3,translocation
R11416 T13321 T13322 themeOf GATA-3,interaction
R11417 T13321 T13320 themeOf GATA-3,phospho
R11418 T13322 T13319 themeOf interaction,Prevention
R15079 T17584 T17583 themeOf down-regulation,associated
R15080 T17586 T17587 themeOf serine,phosphorylation
R15081 T17586 T17585 partOf serine,GATA-3
R15082 T17587 T17584 themeOf phosphorylation,down-regulation
R15083 T17589 T17588 themeOf phosphorylation,effect
R15084 T17590 T17589 themeOf activated transcription factor 2,phosphorylation
R15085 T17591 T17590 equivalentTo ATF-2,activated transcription factor 2
R15086 T17594 T17596 partOf serine,GATA-3
R15087 T17594 T17595 themeOf serine,phosphorylation
R15088 T17595 T17593 themeOf phosphorylation,induced
R15089 T17595 T17592 themeOf phosphorylation,decrease
R15090 T17597 T17599 themeOf induced,dependent
R15091 T17598 T17597 themeOf MKP-1,induced
R15092 T17600 T17602 themeOf induces,dependent
R15093 T17601 T17600 themeOf MKP-1,induces
R15645 T18279 T18278 themeOf GATA-3,phospho
R15646 T18280 T18281 causeOf GR,enhances
R15647 T18282 T18283 themeOf GR,binding
R15648 T18283 T18281 themeOf binding,enhances
R15649 T18286 T18285 themeOf GR,activated
R15650 T18287 T18288 causeOf GATA-3,attenuate
R15651 T18289 T18290 themeOf GR,association
R15652 T18290 T18288 themeOf association,attenuate
R15653 T18292 T18293 causeOf GR,blocks
R15654 T18292 T18291 themeOf GR,Activated
R15655 T18295 T18296 themeOf GATA-3,interacting
R15656 T18295 T18294 themeOf GATA-3,phospho
R15657 T18296 T18293 themeOf interacting,blocks
R15658 T18299 T18300 themeOf GATA-3,binding
R15659 T18300 T18298 themeOf binding,stimulated
R15660 T18303 T18301 themeOf GR,activated
R15661 T18303 T18302 themeOf GR,unstimulated
R15662 T18303 T18304 causeOf GR,attenuation
R15663 T18304 T18307 themeOf attenuation,dependent
R15664 T18305 T18306 themeOf GATA-3,association
R15665 T18306 T18304 themeOf association,attenuation
R15967 T18703 T18699 themeOf localization,prevent
R15968 T18703 T18700 themeOf localization,stimulated
R15969 T18705 T18706 themeOf GATA-3,degradation
R15970 T18706 T18704 themeOf degradation,affect
R15971 T18710 T18712 themeOf p65,translocation
R15972 T18711 T18712 locationOf nuclear,translocation
R15973 T18712 T18708 themeOf translocation,prevent
R15974 T18712 T18709 themeOf translocation,stimulated
R16816 T19699 T19701 themeOf GATA-3,localization
R16817 T19700 T19701 locationOf nuclear,localization
R16818 T19701 T19698 themeOf localization,impairs
R16819 T19702 T19705 themeOf GR,localisation
R16820 T19703 T19706 themeOf GATA-3,localisation
R16821 T19704 T19705 locationOf nuclear,localisation
R16822 T19704 T19706 locationOf nuclear,localisation
R16823 T19710 T19708 themeOf decrease,dependent
R16824 T19711 T19712 locationOf nuclear,expression
R16825 T19712 T19710 themeOf expression,decrease
R16826 T19713 T19712 themeOf GATA-3,expression
R16827 T19714 T19709 themeOf increased,dependent
R16828 T19715 T19717 locationOf cytoplasmic,expression
R16829 T19716 T19717 themeOf GATA-3,expression
R16830 T19717 T19714 themeOf expression,increased
R16831 T19719 T19720 locationOf nuclear,expression
R16832 T19720 T19718 themeOf expression,decrease
R16833 T19721 T19720 themeOf GATA-3,expression
R16834 T19722 T19724 locationOf cytoplasmic,expression
R16835 T19723 T19724 themeOf GATA-3,expression
R11398 T13300 T13302 themeOf IL-5,release
R11292 T13166 T13167 locationOf nuclear,import
R11293 T13167 T13168 themeOf import,via
R11375 T13270 T13279 themeOf GATA-3,translocation
R11379 T13273 T13277 causeOf attenuating,preventing
R11384 T13278 T13279 locationOf nuclear,translocation
R11385 T13279 T13277 themeOf translocation,preventing
R11386 T13280 T13282 themeOf serine residue,phosphorylated
R11387 T13280 T13281 partOf serine residue,GATA-3
R11388 T13284 T13286 themeOf GATA-3,import
R11389 T13285 T13286 locationOf nuclear,import
R11390 T13286 T13283 themeOf import,impairment
R11391 T13288 T13287 themeOf expression,inhibitory effect
R11392 T13289 T13288 themeOf IL-4,expression
R11393 T13291 T13292 themeOf IL-4,transcription
R11394 T13292 T13290 themeOf transcription,suppress
R11395 T13293 T13294 themeOf GATA-3,inhibition
R11396 T13296 T13295 themeOf GATA-3,inhibiting
R11397 T13299 T13301 themeOf IL-4,release
R11399 T13301 T13298 themeOf release,suppress
R11400 T13302 T13297 themeOf release,suppress
R11290 T13165 T13164 themeOf GATA-3,activated
R11291 T13165 T13167 themeOf GATA-3,import
R11353 T13240 T13241 locationOf nuclear,export
R11355 T13243 T13244 themeOf GATA-3,degradation
R11356 T13244 T13242 themeOf degradation,induces
R11357 T13246 T13245 themeOf GR,activated
R11358 T13246 T13247 causeOf GR,attenuate
R11359 T13249 T13250 themeOf GATA-3,association
R11360 T13249 T13248 themeOf GATA-3,phospho
R11361 T13250 T13247 themeOf association,attenuate
R11362 T13252 T13251 themeOf GATA-3,phospho
R11363 T13252 T13253 themeOf GATA-3,associate
R11364 T13255 T13254 themeOf reduction,contribute
R11365 T13256 T13258 themeOf GATA-3,import
R11366 T13257 T13258 locationOf nuclear,import
R13739 T16003 T16000 themeOf import,inhibits
R13737 T16001 T16003 themeOf GATA-3,import
R13738 T16002 T16003 locationOf nuclear,import
R13740 T16005 T16004 themeOf GATA-3,translocation
R13741 T16006 T16004 locationOf nucleus,translocation
R13742 T16008 T16009 locationOf nuclear,localization
R13743 T16009 T16011 themeOf localization,induced
R13744 T16010 T16009 themeOf GATA-3,localization
R13745 T16015 T16017 themeOf IL-4,mRNA expression
R13746 T16016 T16018 themeOf IL-5,mRNA expression
R13747 T16017 T16014 themeOf mRNA expression,inhibits
R13748 T16018 T16013 themeOf mRNA expression,inhibits
R13749 T16019 T16022 themeOf CD3,costimulated
R13750 T16020 T16021 themeOf CD28,costimulated
R13751 T16025 T16026 themeOf GATA-3,associate
R13752 T16025 T16024 themeOf GATA-3,stimulated
R13753 T16026 T16023 themeOf associate,reduces
R13754 T16028 T16026 themeOf promoter,associate
R13755 T16028 T16027 partOf promoter,IL-5
R6293 T7352 T7351 themeOf GATA-3-GFP,expressing
R7075 T8187 T8189 themeOf GATA-3,Translocation
R7076 T8188 T8189 locationOf Nuclear,Translocation
R7077 T8189 T8185 themeOf Translocation,Effect
R7078 T8190 T8186 themeOf IL-4,Effect
R7079 T8192 T8191 themeOf inhibiting,effective
R7080 T8193 T8194 causeOf GATA-3,regulated
R7081 T8194 T8192 themeOf regulated,inhibiting
R7082 T8195 T8196 themeOf IL-4,expression
R7083 T8196 T8194 themeOf expression,regulated
R7084 T8198 T8197 themeOf stimulated,affect
R7085 T8199 T8200 locationOf nuclear,import
R7086 T8200 T8198 themeOf import,stimulated
R7087 T8201 T8200 themeOf GATA-3,import
R7088 T8203 T8205 locationOf nuclear,translocation
R7089 T8204 T8205 themeOf GATA-3,translocation
R15962 T18696 T18697 themeOf GATA-3,export
R15963 T18697 T18695 themeOf export,affect
R15964 T18699 T18698 themeOf prevent,affect
R15965 T18701 T18703 themeOf GATA-3,localization
R15966 T18702 T18703 locationOf nuclear,localization
R9596 T11225 T11227 themeOf GATA-3,Localization
R9597 T11226 T11227 locationOf Nuclear,Localization
R9598 T11227 T11224 themeOf Localization,Inhibitory
R9599 T11229 T11228 themeOf decrease,dependent
R9600 T11230 T11229 themeOf interaction,decrease
R9601 T11230 T11233 themeOf interaction,inhibited
R9602 T11230 T11234 themeOf interaction,attenuated
R9603 T11232 T11230 themeOf GATA-3,interaction
R9604 T11232 T11231 themeOf GATA-3,phospho
R9605 T11237 T11240 themeOf IL-4,expression
R9606 T11238 T11239 themeOf -5,expression
R9607 T11239 T11235 themeOf expression,suppresses
R9608 T11240 T11236 themeOf expression,suppresses
R9609 T11242 T11241 themeOf interaction,attenuated
R9610 T11243 T11242 themeOf GATA-3,interaction
R9611 T11244 T11247 themeOf reduced,dependent
R9612 T11245 T11246 themeOf GATA-3,interaction
R9613 T11246 T11244 themeOf interaction,reduced
R9614 T11249 T11248 themeOf decrease,produced
R9615 T11250 T11251 themeOf GATA-3,association
R9616 T11251 T11249 themeOf association,decrease
R9617 T11252 T11253 themeOf GATA-3,association
R9618 T11255 T11254 themeOf interaction,attenuated
R9619 T11256 T11255 themeOf GATA-3,interaction
R9620 T11258 T11257 themeOf localization,affect
R9621 T11259 T11258 themeOf GATA-3,localization
R9622 T11261 T11263 themeOf GR,translocation
R71 T99 T96 themeOf expression,regulating
R72 T100 T98 themeOf expression,regulating
R74 T102 T100 themeOf interleukin (IL)-4,expression
R769 T91 T94 themeOf GATA-3,Phosphorylation
R774 T95 T98 causeOf GATA-3,regulating
R775 T95 T96 causeOf GATA-3,regulating
R73 T101 T97 themeOf expression,regulating
R75 T103 T99 themeOf IL-5,expression
R76 T104 T101 themeOf IL-13,expression
R77 T107 T108 themeOf GATA-3,regulation
R78 T108 T106 themeOf regulation,effect
R79 T110 T111 locationOf nuclear,translocation
R80 T111 T109 themeOf translocation,inhibits
R81 T112 T111 themeOf GATA-3,translocation
R82 T115 T120 themeOf GATA-3,transport
R83 T117 T119 themeOf glucocorticoid receptor,transport
R84 T117 T116 themeOf glucocorticoid receptor,activated
R85 T118 T120 locationOf nuclear,transport
R86 T118 T119 locationOf nuclear,transport
R87 T119 T113 themeOf transport,competition
R88 T120 T114 themeOf transport,competition
R89 T122 T121 themeOf expression,induces
R90 T123 T122 themeOf mitogen-activated protein kinase (MAPK) phosphatase-1,expression
R91 T124 T123 equivalentTo MKP-1,mitogen-activated protein kinase (MAPK) phosphatase-1
R92 T126 T128 themeOf GATA-3,translocation
R93 T127 T128 locationOf nuclear,translocation
R94 T128 T125 themeOf translocation,necessary
R95 T130 T132 themeOf GATA-3,translocation
R96 T131 T132 locationOf nuclear,translocation
R97 T132 T129 themeOf translocation,inhibits
R98 T134 T133 themeOf GATA-3,inhibitory effect
R770 T91 T93 themeOf GATA-3,Import
R771 T92 T93 locationOf Nuclear,Import
R772 T93 T89 themeOf Import,Suppression
R773 T94 T90 themeOf Phosphorylation,Suppression
R776 T95 T97 causeOf GATA-3,regulating
R3730 T4347 T4348 themeOf GATA-3,localization
R7683 T8915 T8916 themeOf GATA-3,for
R7684 T8918 T8917 themeOf GR,activated
R7685 T8918 T8924 themeOf GR,import
R7686 T8919 T8923 themeOf GATA-3,import
R7687 T8922 T8924 locationOf nuclear,import
R7688 T8922 T8923 locationOf nuclear,import
R7689 T8923 T8920 themeOf import,uses
R7690 T8924 T8921 themeOf import,uses
R7691 T8926 T8928 themeOf GR,translocation
R7692 T8927 T8928 locationOf nuclear,translocation
R7693 T8929 T8933 themeOf decreased,dependent
R7694 T8930 T8929 themeOf association,decreased
R959 T1187 T1188 themeOf GATA-3,expressed
R960 T1189 T1191 causeOf GATA-3,activates
R961 T1189 T1192 causeOf GATA-3,activates
R962 T1189 T1190 causeOf GATA-3,activates
R963 T1193 T1191 themeOf promoters,activates
R964 T1193 T1195 partOf promoters,IL-5
R965 T1193 T1192 themeOf promoters,activates
R966 T1193 T1194 partOf promoters,IL-4
R967 T1193 T1190 themeOf promoters,activates
R968 T1193 T1196 partOf promoters,IL-13
R969 T1203 T1204 themeOf GATA-3,expression
R8230 T9585 T9584 themeOf MKP-1,induction
R8231 T9586 T9585 equivalentTo MAPK phosphatase-1,MKP-1
R8232 T9588 T9587 themeOf phosphorylation,decreased
R8235 T9591 T9596 themeOf reduced,dependent
R8240 T9598 T9599 themeOf GATA-3,phosphorylation
R8241 T9599 T9597 themeOf phosphorylation,This reduction
R8242 T9600 T9603 themeOf induced,dependent
R8243 T9601 T9602 themeOf MKP-1,mRNA
R8244 T9602 T9600 themeOf mRNA,induced
R8245 T9607 T9609 themeOf GATA-3,import
R8246 T9607 T9610 themeOf GATA-3,association
R8247 T9608 T9609 locationOf nuclear,import
R8248 T9609 T9606 themeOf import,effects
R8249 T9610 T9604 themeOf association,effects
R8250 T9611 T9612 themeOf IL-4,mRNA expression
R8251 T9612 T9605 themeOf mRNA expression,effects
R8252 T9616 T9613 themeOf GATA-3,competition
R8253 T9616 T9615 themeOf GATA-3,activated
R8254 T9618 T9614 themeOf GR,competition
R8255 T9618 T9617 themeOf GR,activated
R8256 T9620 T9619 themeOf GR,activated
R8257 T9620 T9621 causeOf GR,increased
R8258 T9621 T9624 themeOf increased,in the presence and absence of
R8259 T9622 T9623 themeOf GR,association
R8260 T9623 T9621 themeOf association,increased
R8261 T9625 T9624 causeOf activated,in the presence and absence of
R8262 T9626 T9625 themeOf GATA-3,activated
R8263 T9628 T9627 themeOf GATA-3,activated
R8264 T9628 T9629 causeOf GATA-3,block
R8265 T9630 T9631 themeOf GR,association
R8266 T9631 T9629 themeOf association,block
R8267 T9633 T9632 themeOf GR,activated
R8268 T9633 T9635 themeOf GR,associate
R8233 T9590 T9588 themeOf ATF-2,phosphorylation
R8234 T9590 T9589 themeOf ATF-2,target
R8236 T9593 T9594 themeOf serine,phosphorylation
R8237 T9593 T9592 partOf serine,GATA-3
R8238 T9594 T9591 themeOf phosphorylation,reduced
R8239 T9594 T9595 themeOf phosphorylation,induced
R8269 T9634 T9636 themeOf GATA-3,associate
R8270 T9638 T9637 themeOf GR,activated
R8271 T9638 T9639 causeOf GR,attenuates
R8272 T9639 T9643 themeOf attenuates,dependent
R8273 T9641 T9642 themeOf GATA-3,interaction
R8274 T9641 T9640 themeOf GATA-3,phospho
R8275 T9642 T9639 themeOf interaction,attenuates
R8276 T9645 T9644 themeOf GR,activated
R8277 T9645 T9646 causeOf GR,compete
R8278 T9646 T9649 causeOf compete,limit
R8279 T9647 T9648 themeOf GATA-3,for
R8280 T9648 T9646 themeOf for,compete
R8281 T9650 T9652 themeOf GATA-3,import
R14391 T16791 T16792 themeOf GATA-3,association
R14392 T16792 T16789 themeOf association,reduces
R14393 T16793 T16795 themeOf GATA-3,import
R14394 T16794 T16795 locationOf nuclear,import
R14395 T16795 T16790 themeOf import,reduces
R14396 T16797 T16796 themeOf induction,dependent
R14397 T16799 T16800 themeOf GR,interaction
R14398 T16799 T16798 themeOf GR,activated
R14399 T16800 T16797 themeOf interaction,induction
R14400 T16801 T16802 themeOf GR,association
R14401 T16804 T16803 themeOf induction,dependent
R14402 T16806 T16808 themeOf GR,translocation
R14403 T16806 T16805 themeOf GR,activated
R14404 T16807 T16808 locationOf nuclear,translocation
R14405 T16808 T16804 themeOf translocation,induction
R14406 T16810 T16809 themeOf decrease,dependent
R14407 T16811 T16812 themeOf GATA-3,association
R14408 T16812 T16810 themeOf association,decrease
R14409 T16813 T16814 themeOf GATA-3,overexpressed
R16449 T19275 T19276 themeOf GATA-3,interaction
R16450 T19276 T19273 themeOf interaction,impairs
R16451 T19277 T19279 themeOf GATA-3,localization
R16452 T19278 T19279 locationOf nuclear,localization
R16453 T19279 T19274 themeOf localization,impairs
R16454 T19281 T19280 themeOf interaction,impaired
R16455 T19282 T19281 themeOf GATA-3,interaction
R16456 T19284 T19283 themeOf association,decreased
R16457 T19285 T19284 themeOf GATA-3,association

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T430 15-21 P23771 denotes GATA-3
T431 466-472 P23771 denotes GATA-3
T432 561-565 P05113 denotes IL-5
T433 571-576 P35225 denotes IL-13
T434 755-761 P23771 denotes GATA-3
T435 850-856 P23771 denotes GATA-3
T436 1030-1033 P04234 denotes CD3
T437 1030-1033 P20963 denotes CD3
T438 1030-1033 P09693 denotes CD3
T439 1030-1033 P07766 denotes CD3
T440 1043-1047 P10747 denotes CD28
T441 1124-1130 P23771 denotes GATA-3
T442 1256-1262 P23771 denotes GATA-3
T443 1288-1311 P04150 denotes glucocorticoid receptor
T444 1426-1458 P27361 denotes mitogen-activated protein kinase
T445 1426-1458 P28482 denotes mitogen-activated protein kinase
T446 1481-1486 P28562 denotes MKP-1
T447 1517-1520 P53778 denotes p38
T448 1517-1520 Q16539 denotes p38
T449 1517-1520 Q15759 denotes p38
T450 1517-1520 O15264 denotes p38
T451 1550-1556 P23771 denotes GATA-3
T452 1709-1715 P23771 denotes GATA-3
T453 1867-1873 P23771 denotes GATA-3
T2224 7392-7396 P05113 denotes IL-5
T2225 7402-7407 P35225 denotes IL-13
T2226 7437-7441 P05112 denotes IL-4
T2227 7446-7451 P35225 denotes IL-13
T2228 7511-7515 P05113 denotes IL-5
T2229 7635-7641 P23771 denotes GATA-3
T2230 7698-7704 P23771 denotes GATA-3
T2231 7784-7788 P05112 denotes IL-4
T2232 7790-7794 P05113 denotes IL-5
T2233 7800-7805 P35225 denotes IL-13
T2234 7861-7867 P23771 denotes GATA-3
T2235 8023-8029 P23771 denotes GATA-3
T2236 8088-8094 P23771 denotes GATA-3
T2237 8146-8151 P23771 denotes Gata3
T2238 8286-8289 P01730 denotes CD4
T2239 8331-8337 P23771 denotes GATA-3
T2240 8402-8405 P09693 denotes CD3
T2241 8402-8405 P20963 denotes CD3
T2242 8402-8405 P04234 denotes CD3
T2243 8402-8405 P07766 denotes CD3
T2244 8406-8410 P10747 denotes CD28
T2245 8463-8469 P23771 denotes GATA-3
T2246 8614-8620 P23771 denotes GATA-3
T2247 8808-8814 P23771 denotes GATA-3
T2248 9014-9020 P23771 denotes GATA-3
T2249 9243-9246 Q16539 denotes p38
T2250 9243-9246 P53778 denotes p38
T2251 9243-9246 Q15759 denotes p38
T2252 9243-9246 O15264 denotes p38
T2253 9247-9279 P28482 denotes mitogen-activated protein kinase
T2254 9247-9279 P27361 denotes mitogen-activated protein kinase
T2255 9328-9334 P23771 denotes GATA-3
T2256 9663-9687 P04150 denotes glucocorticoid receptors
T2257 9689-9692 P04150 denotes GRs
T2258 9875-9877 P04150 denotes GR
T2259 10193-10195 P04150 denotes GR
T2260 10683-10685 P04150 denotes GR
T2261 10946-10948 P04150 denotes GR
T2262 11030-11032 P04150 denotes GR
T2263 11366-11370 P05112 denotes IL-4
T2264 11372-11376 P05113 denotes IL-5
T2265 11382-11387 P35225 denotes IL-13
T2266 11590-11592 P04150 denotes GR
T2267 11601-11607 P23771 denotes GATA-3
T2268 11617-11621 P05113 denotes IL-5
T2269 11657-11660 P01730 denotes CD4
T2270 11720-11722 P04150 denotes GR
T2271 11748-11754 P23771 denotes GATA-3
T2272 11974-11980 P23771 denotes GATA-3
T2273 12120-12123 P07766 denotes CD3
T2274 12120-12123 P09693 denotes CD3
T2275 12120-12123 P04234 denotes CD3
T2276 12120-12123 P20963 denotes CD3
T2277 12133-12137 P10747 denotes CD28
T2278 12221-12227 P23771 denotes GATA-3
T4128 13206-13209 P09693 denotes CD3
T4129 13206-13209 P07766 denotes CD3
T4130 13206-13209 P04234 denotes CD3
T4131 13206-13209 P20963 denotes CD3
T4132 13211-13215 P10747 denotes CD28
T4133 13217-13219 P04150 denotes GR
T4134 13329-13335 P23771 denotes GATA-3
T4135 13347-13349 P04150 denotes GR
T4136 13496-13499 Q16539 denotes p38
T4137 13496-13499 P53778 denotes p38
T4138 13496-13499 Q15759 denotes p38
T4139 13496-13499 O15264 denotes p38
T4140 13523-13528 P15336 denotes ATF-2
T4141 13795-13797 P04150 denotes GR
T5739 16679-16681 P04150 denotes GR
T5740 16682-16688 P23771 denotes GATA-3
T5741 16938-16944 P23771 denotes GATA-3
T5742 17031-17034 P04234 denotes CD3
T5743 17031-17034 P09693 denotes CD3
T5744 17031-17034 P20963 denotes CD3
T5745 17031-17034 P07766 denotes CD3
T5746 17035-17039 P10747 denotes CD28
T5747 17044-17046 P04150 denotes GR
T5748 17315-17321 P23771 denotes GATA-3
T5749 17422-17424 P04150 denotes GR
T5750 17631-17637 P23771 denotes GATA-3
T5751 17653-17655 P04150 denotes GR
T5752 17819-17825 P23771 denotes GATA-3
T5753 17927-17929 P04150 denotes GR
T6927 19780-19786 P23771 denotes GATA-3
T6928 19787-19790 Q9U6Y4 denotes GFP
T6929 19805-19811 P23771 denotes GATA-3
T6930 19923-19929 P23771 denotes GATA-3
T6931 19951-19957 P23771 denotes GATA-3
T6932 20161-20167 P23771 denotes GATA-3
T6933 20427-20433 P23771 denotes GATA-3
T6934 20451-20454 Q9U6Y4 denotes GFP
T6935 20533-20539 P23771 denotes GATA-3
T6936 20595-20598 Q9U6Y4 denotes GFP
T8423 23205-23211 P23771 denotes GATA-3
T8424 23238-23242 P05112 denotes IL-4
T8425 23292-23298 P23771 denotes GATA-3
T8426 23309-23313 P05112 denotes IL-4
T8427 23419-23422 P04234 denotes CD3
T8428 23419-23422 P20963 denotes CD3
T8429 23419-23422 P07766 denotes CD3
T8430 23419-23422 P09693 denotes CD3
T8431 23423-23427 P10747 denotes CD28
T8432 23457-23463 P23771 denotes GATA-3
T8433 23496-23499 P04234 denotes CD3
T8434 23496-23499 P20963 denotes CD3
T8435 23496-23499 P07766 denotes CD3
T8436 23496-23499 P09693 denotes CD3
T8437 23500-23504 P10747 denotes CD28
T8438 23545-23551 P23771 denotes GATA-3
T8439 23720-23725 Q02750 denotes MEK-1
T8440 23817-23823 P23771 denotes GATA-3
T8441 23864-23870 P23771 denotes GATA-3
T8442 24143-24146 P20963 denotes CD3
T8443 24143-24146 P09693 denotes CD3
T8444 24143-24146 P07766 denotes CD3
T8445 24143-24146 P04234 denotes CD3
T8446 24147-24151 P10747 denotes CD28
T8447 24163-24167 P05112 denotes IL-4
T8448 24172-24176 P05113 denotes IL-5
T8449 24219-24225 P23771 denotes GATA-3
T8450 24248-24252 P05113 denotes IL-5
T9089 25841-25843 P04150 denotes GR
T9090 25858-25864 P23771 denotes GATA-3
T9091 25955-25957 P04150 denotes GR
T9092 25969-25975 P23771 denotes GATA-3
T9093 26060-26062 P04150 denotes GR
T9094 26173-26175 P04150 denotes GR
T9095 26369-26375 P23771 denotes GATA-3
T9096 26407-26410 P09693 denotes CD3
T9097 26407-26410 P20963 denotes CD3
T9098 26407-26410 P07766 denotes CD3
T9099 26407-26410 P04234 denotes CD3
T9100 26411-26415 P10747 denotes CD28
T9101 26496-26499 Q9U6Y4 denotes GFP
T9102 26509-26515 P23771 denotes GATA-3
T9103 26561-26567 P23771 denotes GATA-3
T9104 26598-26601 P09693 denotes CD3
T9105 26598-26601 P07766 denotes CD3
T9106 26598-26601 P04234 denotes CD3
T9107 26598-26601 P20963 denotes CD3
T9108 26602-26606 P10747 denotes CD28
T10140 28261-28266 P28562 denotes MKP-1
T10141 28290-28293 Q15759 denotes p38
T10142 28290-28293 P53778 denotes p38
T10143 28290-28293 O15264 denotes p38
T10144 28290-28293 Q16539 denotes p38
T10145 28398-28403 P28562 denotes MKP-1
T10146 28525-28528 P09693 denotes CD3
T10147 28525-28528 P07766 denotes CD3
T10148 28525-28528 P20963 denotes CD3
T10149 28525-28528 P04234 denotes CD3
T10150 28529-28533 P10747 denotes CD28
T10151 28567-28570 O15264 denotes p38
T10152 28567-28570 Q16539 denotes p38
T10153 28567-28570 Q15759 denotes p38
T10154 28567-28570 P53778 denotes p38
T10155 28670-28675 P15336 denotes ATF-2
T10156 28805-28811 P23771 denotes GATA-3
T10157 28851-28854 P09693 denotes CD3
T10158 28851-28854 P04234 denotes CD3
T10159 28851-28854 P07766 denotes CD3
T10160 28851-28854 P20963 denotes CD3
T10161 28855-28859 P10747 denotes CD28
T10162 28954-28960 P23771 denotes GATA-3
T10163 29063-29068 P28562 denotes MKP-1
T10164 29218-29224 P23771 denotes GATA-3
T10165 29268-29272 P05112 denotes IL-4
T10166 30745-30751 P23771 denotes GATA-3
T10167 30779-30781 P04150 denotes GR
T10168 30814-30816 P04150 denotes GR
T10169 30841-30843 P04150 denotes GR
T10170 30908-30914 P23771 denotes GATA-3
T10171 30971-30977 P23771 denotes GATA-3
T10172 30992-30994 P04150 denotes GR
T10173 31075-31077 P04150 denotes GR
T10174 31090-31096 P23771 denotes GATA-3
T10175 31167-31169 P04150 denotes GR
T10176 31193-31199 P23771 denotes GATA-3
T10177 31318-31320 P04150 denotes GR
T10178 31346-31352 P23771 denotes GATA-3
T10179 31386-31392 P23771 denotes GATA-3
T10180 32576-32582 P23771 denotes GATA-3
T10181 32705-32711 P23771 denotes GATA-3
T10182 32791-32797 P23771 denotes GATA-3
T10183 32908-32911 P20963 denotes CD3
T10184 32908-32911 P09693 denotes CD3
T10185 32908-32911 P07766 denotes CD3
T10186 32908-32911 P04234 denotes CD3
T10187 32912-32916 P10747 denotes CD28
T10188 32946-32952 P23771 denotes GATA-3
T10189 33010-33012 P04150 denotes GR
T10190 33030-33036 P23771 denotes GATA-3
T10191 33082-33088 P23771 denotes GATA-3
T10192 33160-33163 Q04206 denotes p65
T10193 33160-33163 P21579 denotes p65
T11896 34313-34319 P23771 denotes GATA-3
T11897 34502-34508 P23771 denotes GATA-3
T11898 35764-35768 P05112 denotes IL-4
T11899 35826-35832 P23771 denotes GATA-3
T11900 36086-36092 P23771 denotes GATA-3
T11901 36185-36191 P23771 denotes GATA-3
T11902 36483-36489 P23771 denotes GATA-3
T11903 36625-36631 P23771 denotes GATA-3
T11904 36879-36885 P23771 denotes GATA-3
T11905 36982-36984 P04150 denotes GR
T11906 37069-37075 P23771 denotes GATA-3
T11907 37460-37466 P23771 denotes GATA-3
T11908 37603-37609 P23771 denotes GATA-3
T11909 37831-37834 O15264 denotes p38
T11910 37831-37834 Q16539 denotes p38
T11911 37831-37834 Q15759 denotes p38
T11912 37831-37834 P53778 denotes p38
T11913 39499-39505 P23771 denotes GATA-3
T11914 39544-39550 P23771 denotes GATA-3
T11915 39689-39692 Q16539 denotes p38
T11916 39689-39692 P53778 denotes p38
T11917 39689-39692 Q15759 denotes p38
T11918 39689-39692 O15264 denotes p38
T11919 39707-39713 P23771 denotes GATA-3
T11920 39753-39758 P28562 denotes MKP-1
T11921 39847-39853 P23771 denotes GATA-3
T14226 40017-40023 P23771 denotes GATA-3
T14227 40167-40169 P04150 denotes GR
T14228 40204-40210 P23771 denotes GATA-3
T14229 40298-40304 P23771 denotes GATA-3
T14230 40309-40311 P04150 denotes GR
T14231 40391-40396 P28562 denotes MKP-1
T14232 40420-40423 Q16539 denotes p38
T14233 40420-40423 Q15759 denotes p38
T14234 40420-40423 P53778 denotes p38
T14235 40420-40423 O15264 denotes p38
T14236 40500-40503 P53778 denotes p38
T14237 40500-40503 Q15759 denotes p38
T14238 40500-40503 Q16539 denotes p38
T14239 40500-40503 O15264 denotes p38
T14240 40543-40549 P23771 denotes GATA-3
T14241 40678-40684 P23771 denotes GATA-3
T14242 40808-40814 P23771 denotes GATA-3
T14243 40859-40865 P23771 denotes GATA-3
T14244 40919-40922 P04234 denotes CD3
T14245 40919-40922 P09693 denotes CD3
T14246 40919-40922 P20963 denotes CD3
T14247 40919-40922 P07766 denotes CD3
T14248 40923-40927 P10747 denotes CD28
T14249 40939-40943 P05112 denotes IL-4
T14250 40944-40948 P05113 denotes IL-5
T14251 41004-41010 P23771 denotes GATA-3
T14252 41092-41094 P04150 denotes GR
T14253 41142-41148 P23771 denotes GATA-3
T14254 41227-41229 P04150 denotes GR
T14255 41242-41248 P23771 denotes GATA-3
T14256 41358-41360 P04150 denotes GR
T14257 41374-41380 P23771 denotes GATA-3
T14258 41434-41440 P23771 denotes GATA-3
T14259 41597-41603 P23771 denotes GATA-3
T14260 41637-41640 Q04206 denotes p65
T14261 41637-41640 P21579 denotes p65
T14262 41768-41774 P23771 denotes GATA-3
T14263 41836-41842 P23771 denotes GATA-3
T14264 41878-41884 P23771 denotes GATA-3
T14265 41995-41997 P04150 denotes GR
T14266 42037-42043 P23771 denotes GATA-3
T14267 42150-42156 P23771 denotes GATA-3
T14268 42399-42405 P23771 denotes GATA-3
T14269 42521-42526 P28562 denotes MKP-1
T14270 42567-42570 P53778 denotes p38
T14271 42567-42570 O15264 denotes p38
T14272 42567-42570 Q16539 denotes p38
T14273 42567-42570 Q15759 denotes p38
T14274 42610-42615 P28562 denotes MKP-1
T14275 42711-42716 P28562 denotes MKP-1
T14276 42758-42768 Q04864 denotes relatively
T14277 42840-42845 P28562 denotes MKP-1
T14278 42857-42863 P23771 denotes GATA-3
T14279 42894-42897 Q16539 denotes p38
T14280 42894-42897 P53778 denotes p38
T14281 42894-42897 Q15759 denotes p38
T14282 42894-42897 O15264 denotes p38
T14283 42927-42933 P23771 denotes GATA-3
T14284 43031-43037 P23771 denotes GATA-3
T14285 43065-43068 P53778 denotes p38
T14286 43065-43068 O15264 denotes p38
T14287 43065-43068 Q15759 denotes p38
T14288 43065-43068 Q16539 denotes p38
T14294 43522-43526 P05112 denotes IL-4
T14295 43693-43697 P05112 denotes IL-4
T14296 43854-43860 P23771 denotes GATA-3
T14297 44009-44015 P23771 denotes GATA-3
T14298 44352-44356 P05112 denotes IL-4
T14299 44361-44365 P05113 denotes IL-5
T14300 44604-44610 P23771 denotes GATA-3
T14301 44764-44769 P28562 denotes MKP-1
T14302 44786-44789 Q16539 denotes p38
T14303 44786-44789 Q15759 denotes p38
T14304 44786-44789 P53778 denotes p38
T14305 44786-44789 O15264 denotes p38
T14306 44835-44841 P23771 denotes GATA-3
T14307 44889-44895 P23771 denotes GATA-3
T14308 45258-45264 P23771 denotes GATA-3
T16280 24399-24405 P23771 denotes GATA-3
T16281 24431-24434 P09693 denotes CD3
T16282 24431-24434 P20963 denotes CD3
T16283 24431-24434 P04234 denotes CD3
T16284 24431-24434 P07766 denotes CD3
T16285 24435-24439 P10747 denotes CD28
T16286 24494-24500 P23771 denotes GATA-3
T16287 24569-24574 Q02750 denotes MEK-1
T16288 24782-24788 P23771 denotes GATA-3
T16289 24805-24808 P04234 denotes CD3
T16290 24805-24808 P20963 denotes CD3
T16291 24805-24808 P07766 denotes CD3
T16292 24805-24808 P09693 denotes CD3
T16293 24809-24813 P10747 denotes CD28
T16294 24985-24989 Q02750 denotes MEK1
T16295 25244-25248 P05112 denotes IL-4
T16296 25253-25257 P05113 denotes IL-5
T16297 25277-25280 P09693 denotes CD3
T16298 25277-25280 P04234 denotes CD3
T16299 25277-25280 P07766 denotes CD3
T16300 25277-25280 P20963 denotes CD3
T16301 25281-25285 P10747 denotes CD28
T16302 25306-25311 P04406 denotes GAPDH
T16303 25517-25520 P04234 denotes CD3
T16304 25517-25520 P20963 denotes CD3
T16305 25517-25520 P07766 denotes CD3
T16306 25517-25520 P09693 denotes CD3
T16307 25521-25525 P10747 denotes CD28
T16308 25581-25584 P09693 denotes CD3
T16309 25581-25584 P20963 denotes CD3
T16310 25581-25584 P04234 denotes CD3
T16311 25581-25584 P07766 denotes CD3
T16312 25585-25589 P10747 denotes CD28
T16313 25601-25607 P23771 denotes GATA-3
T16314 25637-25641 P05113 denotes IL-5
T17086 26766-26772 P23771 denotes GATA-3
T17087 26805-26811 P23771 denotes GATA-3
T17088 26975-26977 P04150 denotes GR
T17089 27038-27040 P04150 denotes GR
T17090 27398-27400 P04150 denotes GR
T17091 27666-27669 P04234 denotes CD3
T17092 27666-27669 P07766 denotes CD3
T17093 27666-27669 P20963 denotes CD3
T17094 27666-27669 P09693 denotes CD3
T17095 27670-27674 P10747 denotes CD28
T17096 27741-27747 P23771 denotes GATA-3
T17097 27971-27975 P10747 denotes CD28
T17098 27998-28001 Q9U6Y4 denotes GFP
T17099 28009-28015 P23771 denotes GATA-3
T17100 28094-28097 P07766 denotes CD3
T17101 28094-28097 P20963 denotes CD3
T17102 28094-28097 P04234 denotes CD3
T17103 28094-28097 P09693 denotes CD3
T17104 28098-28102 P10747 denotes CD28
T17820 29449-29452 Q15759 denotes p38
T17821 29449-29452 Q16539 denotes p38
T17822 29449-29452 O15264 denotes p38
T17823 29449-29452 P53778 denotes p38
T17824 29542-29548 P23771 denotes GATA-3
T17825 29705-29708 Q16539 denotes p38
T17826 29705-29708 Q15759 denotes p38
T17827 29705-29708 P53778 denotes p38
T17828 29705-29708 O15264 denotes p38
T17829 29722-29725 P04234 denotes CD3
T17830 29722-29725 P09693 denotes CD3
T17831 29722-29725 P07766 denotes CD3
T17832 29722-29725 P20963 denotes CD3
T17833 29726-29730 P10747 denotes CD28
T17834 29826-29858 P15336 denotes activated transcription factor 2
T17835 29860-29865 P15336 denotes ATF-2
T17836 29881-29884 Q16539 denotes p38
T17837 29881-29884 Q15759 denotes p38
T17838 29881-29884 O15264 denotes p38
T17839 29881-29884 P53778 denotes p38
T17840 29929-29932 P53778 denotes p38
T17841 29929-29932 Q16539 denotes p38
T17842 29929-29932 Q15759 denotes p38
T17843 29929-29932 O15264 denotes p38
T17844 29987-29990 P09693 denotes CD3
T17845 29987-29990 P20963 denotes CD3
T17846 29987-29990 P04234 denotes CD3
T17847 29987-29990 P07766 denotes CD3
T17848 29991-29995 P10747 denotes CD28
T17849 30053-30059 P23771 denotes GATA-3
T17850 27971-27975 P10747 denotes CD28
T17851 30298-30303 P28562 denotes MKP-1
T17852 30489-30494 P28562 denotes MKP-1
T18311 31498-31504 P23771 denotes GATA-3
T18312 31597-31599 P04150 denotes GR
T18313 31652-31654 P04150 denotes GR
T18314 31723-31729 P23771 denotes GATA-3
T18315 31765-31767 P04150 denotes GR
T18316 31773-31779 P23771 denotes GATA-3
T18317 31799-31802 P07766 denotes CD3
T18318 31799-31802 P20963 denotes CD3
T18319 31799-31802 P09693 denotes CD3
T18320 31799-31802 P04234 denotes CD3
T18321 31803-31807 P10747 denotes CD28
T18322 31844-31846 P04150 denotes GR
T18323 31914-31916 P04150 denotes GR
T18324 31956-31962 P23771 denotes GATA-3
T18325 31982-31985 P07766 denotes CD3
T18326 31982-31985 P04234 denotes CD3
T18327 31982-31985 P20963 denotes CD3
T18328 31982-31985 P09693 denotes CD3
T18329 31986-31990 P10747 denotes CD28
T18330 32098-32104 P23771 denotes GATA-3
T18331 32171-32177 P23771 denotes GATA-3
T18332 32252-32254 P04150 denotes GR
T18333 32273-32279 P23771 denotes GATA-3
T18898 33301-33307 P23771 denotes GATA-3
T18899 33471-33474 P09693 denotes CD3
T18900 33471-33474 P20963 denotes CD3
T18901 33471-33474 P07766 denotes CD3
T18902 33471-33474 P04234 denotes CD3
T18903 33475-33479 P10747 denotes CD28
T18904 33491-33497 P23771 denotes GATA-3
T18905 25517-25520 P20963 denotes CD3
T18906 25517-25520 P09693 denotes CD3
T18907 25517-25520 P07766 denotes CD3
T18908 25517-25520 P04234 denotes CD3
T18909 25521-25525 P10747 denotes CD28
T18910 33716-33722 P23771 denotes GATA-3
T18911 33750-33753 Q9U6Y4 denotes GFP
T18912 33761-33767 P23771 denotes GATA-3
T18913 33833-33836 P20963 denotes CD3
T18914 33833-33836 P07766 denotes CD3
T18915 33833-33836 P09693 denotes CD3
T18916 33833-33836 P04234 denotes CD3
T18917 33837-33841 P10747 denotes CD28
T18918 33929-33932 P07766 denotes CD3
T18919 33929-33932 P04234 denotes CD3
T18920 33929-33932 P20963 denotes CD3
T18921 33929-33932 P09693 denotes CD3
T18922 33933-33937 P10747 denotes CD28
T18923 33991-33994 P04234 denotes CD3
T18924 33991-33994 P09693 denotes CD3
T18925 33991-33994 P07766 denotes CD3
T18926 33991-33994 P20963 denotes CD3
T18927 33995-33999 P10747 denotes CD28
T18928 34011-34014 Q04206 denotes p65
T18929 34011-34014 P21579 denotes p65
T19426 34820-34826 P23771 denotes GATA-3
T19427 34859-34865 P23771 denotes GATA-3
T19428 35061-35067 P23771 denotes GATA-3
T19429 35442-35448 P23771 denotes GATA-3
T19970 38015-38021 P23771 denotes GATA-3
T19971 38140-38142 P04150 denotes GR
T19972 38147-38153 P23771 denotes GATA-3
T19973 38188-38194 P23771 denotes GATA-3
T19974 38584-38590 P23771 denotes GATA-3
T19975 38618-38624 P23771 denotes GATA-3
T19976 38761-38767 P23771 denotes GATA-3
T19977 38795-38801 P23771 denotes GATA-3
T19978 38856-38861 Q02750 denotes MEK-1
T19979 39296-39299 Q16539 denotes p38
T19980 39296-39299 Q15759 denotes p38
T19981 39296-39299 P53778 denotes p38
T19982 39296-39299 O15264 denotes p38
T4464 14328-14331 P04234 denotes CD3
T4465 14328-14331 P20963 denotes CD3
T4466 14328-14331 P09693 denotes CD3
T4467 14328-14331 P07766 denotes CD3
T4468 14332-14336 P10747 denotes CD28
T4469 14481-14487 P23771 denotes GATA-3
T4715 14889-14897 Q04864 denotes relative
T4716 14968-14972 P05112 denotes IL-4
T5004 15363-15365 P0A7Z4 denotes pH
T5005 15633-15639 P23771 denotes GATA-3
T5006 15857-15863 P23771 denotes GATA-3
T5007 15887-15889 P04150 denotes GR
T5008 15898-15901 Q16539 denotes p38
T5009 15898-15901 Q15759 denotes p38
T5010 15898-15901 P53778 denotes p38
T5011 15898-15901 O15264 denotes p38
T5012 15921-15926 P15336 denotes ATF-2
T5316 16198-16204 P23771 denotes GATA-3
T5317 16391-16395 P05113 denotes IL-5
T6157 18143-18146 Q04206 denotes p65
T6158 18143-18146 P21579 denotes p65
T6159 18340-18343 Q04206 denotes p65
T6160 18340-18343 P21579 denotes p65
T6484 18846-18848 P04150 denotes GR
T6485 18894-18900 P23771 denotes GATA-3
T7248 20785-20788 Q9U6Y4 denotes GFP
T7249 21108-21111 P20963 denotes CD3
T7250 21108-21111 P09693 denotes CD3
T7251 21108-21111 P07766 denotes CD3
T7252 21108-21111 P04234 denotes CD3
T7253 21112-21116 P10747 denotes CD28
T7469 21219-21225 P23771 denotes GATA-3
T7470 21226-21229 Q9U6Y4 denotes GFP
T7471 21605-21609 Q13501 denotes ORCA
T7472 21610-21612 P03372 denotes ER
T7690 21870-21872 P41134 denotes ID
T14289 43221-43224 Q16539 denotes p38
T14290 43221-43224 Q15759 denotes p38
T14291 43221-43224 O15264 denotes p38
T14292 43221-43224 P53778 denotes p38
T14293 43310-43316 P23771 denotes GATA-3

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T47 0-11 Negative_regulation denotes Suppression
T48 15-21 Protein denotes GATA-3
T49 22-29 Entity denotes Nuclear
T50 30-36 Localization denotes Import
T51 41-56 Phosphorylation denotes Phosphorylation
T52 466-472 Protein denotes GATA-3
T53 490-494 Regulation denotes role
T54 498-508 Regulation denotes regulating
T55 513-523 Gene_expression denotes expression
T56 541-559 Protein denotes interleukin (IL)-4
T57 561-565 Protein denotes IL-5
T58 571-576 Protein denotes IL-13
T59 744-751 Regulation denotes effects
T60 755-761 Protein denotes GATA-3
T61 850-856 Protein denotes GATA-3
T62 857-867 Regulation denotes regulation
T63 1090-1098 Negative_regulation denotes inhibits
T64 1099-1106 Entity denotes nuclear
T65 1107-1120 Localization denotes translocation
T66 1124-1130 Protein denotes GATA-3
T67 1135-1145 Gene_expression denotes expression
T68 1179-1190 Regulation denotes independent
T69 1236-1247 Negative_regulation denotes competition
T70 1256-1262 Protein denotes GATA-3
T71 1278-1287 Positive_regulation denotes activated
T72 1288-1311 Protein denotes glucocorticoid receptor
T73 1400-1407 Positive_regulation denotes induces
T74 1412-1422 Gene_expression denotes expression
T75 1426-1479 Protein denotes mitogen-activated protein kinase (MAPK) phosphatase-1
T76 1481-1486 Protein denotes MKP-1
T77 1536-1545 Positive_regulation denotes necessary
T78 1550-1556 Protein denotes GATA-3
T79 1557-1564 Entity denotes nuclear
T80 1565-1578 Localization denotes translocation
T81 1700-1708 Negative_regulation denotes inhibits
T82 1709-1715 Protein denotes GATA-3
T83 1716-1723 Entity denotes nuclear
T84 1724-1737 Localization denotes translocation
T85 1846-1863 Negative_regulation denotes inhibitory effect
T86 1867-1873 Protein denotes GATA-3
T1071 7344-7354 Gene_expression denotes expression
T1072 7372-7390 Protein denotes interleukin (IL)-4
T1073 7392-7396 Protein denotes IL-5
T1074 7402-7407 Protein denotes IL-13
T1075 7437-7441 Protein denotes IL-4
T1076 7446-7451 Protein denotes IL-13
T1077 7452-7460 Regulation denotes regulate
T1078 7465-7475 Gene_expression denotes expression
T1079 7511-7515 Protein denotes IL-5
T1080 7585-7594 Regulation denotes regulated
T1081 7635-7641 Protein denotes GATA-3
T1082 7666-7675 Gene_expression denotes expressed
T1083 7698-7704 Protein denotes GATA-3
T1084 7757-7766 Positive_regulation denotes activates
T1085 7771-7780 Entity denotes promoters
T1086 7784-7788 Protein denotes IL-4
T1087 7790-7794 Protein denotes IL-5
T1088 7800-7805 Protein denotes IL-13
T1089 7861-7867 Protein denotes GATA-3
T1090 7994-8003 Negative_regulation denotes dominant-
T1091 8023-8029 Protein denotes GATA-3
T1092 8088-8094 Protein denotes GATA-3
T1093 8146-8151 Protein denotes Gata3
T1094 8286-8289 Protein denotes CD4
T1095 8318-8327 Negative_regulation denotes knockdown
T1096 8331-8337 Protein denotes GATA-3
T1097 8338-8348 Gene_expression denotes expression
T1098 8463-8469 Protein denotes GATA-3
T1099 8507-8518 Localization denotes translocate
T1100 8547-8554 Entity denotes nucleus
T1101 8583-8591 Positive_regulation denotes Enhanced
T1102 8592-8599 Entity denotes nuclear
T1103 8600-8610 Localization denotes expression
T1104 8614-8620 Protein denotes GATA-3
T1105 8621-8630 Positive_regulation denotes following
T1106 8647-8657 Positive_regulation denotes activation
T1107 8808-8814 Protein denotes GATA-3
T1108 8844-8850 Localization denotes import
T1109 8891-8898 Entity denotes nucleus
T1110 8914-8920 Localization denotes import
T1111 9014-9020 Protein denotes GATA-3
T1112 9185-9194 Regulation denotes regulated
T1113 9198-9213 Phosphorylation denotes phosphorylation
T1114 9304-9308 Regulation denotes role
T1115 9312-9327 Phosphorylation denotes phosphorylating
T1116 9328-9334 Protein denotes GATA-3
T1117 9338-9345 Positive_regulation denotes enhance
T1118 9350-9361 Binding denotes interaction
T1119 9652-9659 Binding denotes binding
T1120 9663-9687 Protein denotes glucocorticoid receptors
T1121 9689-9692 Protein denotes GRs true
T1122 9706-9717 Localization denotes translocate
T1123 9725-9732 Entity denotes nucleus true
T1124 9744-9752 Binding denotes interact
T1125 9865-9874 Positive_regulation denotes activated true
T1126 9875-9877 Protein denotes GR
T1127 9878-9887 Binding denotes interacts
T1128 10076-10087 Binding denotes recruitment
T1129 10122-10143 Protein denotes histone deacetylase-2
T1130 10155-10162 Entity denotes Nuclear
T1131 10163-10175 Localization denotes localisation
T1132 10180-10189 Localization denotes retention
T1133 10193-10195 Protein denotes GR
T1134 10199-10207 Positive_regulation denotes mediated
T1135 10280-10289 Localization denotes retention
T1136 10322-10329 Entity denotes nuclear
T1137 10330-10336 Localization denotes export
T1138 10343-10375 Protein denotes chromosomal region maintenance 1
T1139 10377-10382 Protein denotes CRM-1
T1140 10447-10452 Binding denotes binds
T1141 10673-10682 Positive_regulation denotes resulting
T1142 10683-10685 Protein denotes GR
T1143 10692-10704 Localization denotes translocates
T1144 10712-10719 Entity denotes nucleus
T1145 10720-10734 Positive_regulation denotes in response to
T1146 10752-10763 Binding denotes interaction
T1147 10769-10779 Protein denotes importin 7
T1148 10946-10948 Protein denotes GR
T1149 10949-10955 Localization denotes import
T1150 11016-11026 Regulation denotes regulation
T1151 11030-11032 Protein denotes GR
T1152 11033-11043 Positive_regulation denotes activation
T1153 11048-11055 Entity denotes nuclear
T1154 11056-11062 Localization denotes import
T1155 11142-11149 Binding denotes binding
T1156 11366-11370 Protein denotes IL-4
T1157 11372-11376 Protein denotes IL-5
T1158 11382-11387 Protein denotes IL-13
T1159 11525-11528 Protein denotes CAT
T1160 11590-11592 Protein denotes GR
T1161 11593-11600 Negative_regulation denotes reduced
T1162 11601-11607 Protein denotes GATA-3
T1163 11608-11616 Positive_regulation denotes mediated
T1164 11617-11621 Protein denotes IL-5
T1165 11626-11629 Protein denotes -13
T1166 11657-11660 Protein denotes CD4
T1167 11705-11716 Binding denotes recruitment
T1168 11720-11722 Protein denotes GR
T1169 11727-11732 Regulation denotes alter
T1170 11748-11754 Protein denotes GATA-3
T1171 11765-11769 Binding denotes bind
T1172 11815-11828 Positive_regulation denotes up-regulation
T1173 11974-11980 Protein denotes GATA-3
T1174 11981-11996 Phosphorylation denotes phosphorylation
T1175 12001-12008 Entity denotes nuclear
T1176 12009-12022 Localization denotes translocation
T1177 12221-12227 Protein denotes GATA-3
T1178 12240-12252 Localization denotes localization
T3964 13206-13209 Protein denotes CD3
T3965 13211-13215 Protein denotes CD28
T3966 13217-13219 Protein denotes GR
T3967 13329-13335 Protein denotes GATA-3
T3968 13347-13349 Protein denotes GR
T3969 13523-13528 Protein denotes ATF-2
T4345 14481-14487 Protein denotes GATA-3
T4346 14488-14500 Localization denotes localization
T4613 14968-14972 Protein denotes IL-4
T4844 15633-15639 Protein denotes GATA-3
T5200 16391-16395 Protein denotes IL-5
T5473 16679-16681 Protein denotes GR
T5474 16682-16688 Protein denotes GATA-3
T5475 16938-16944 Protein denotes GATA-3
T5476 17044-17046 Protein denotes GR
T5477 17315-17321 Protein denotes GATA-3
T5478 17422-17424 Protein denotes GR
T5479 17819-17825 Protein denotes GATA-3
T5480 17927-17929 Protein denotes GR
T6072 18143-18146 Protein denotes p65
T6270 18846-18848 Protein denotes GR
T6747 19780-19786 Protein denotes GATA-3
T6748 19787-19790 Protein denotes GFP
T6749 19805-19811 Protein denotes GATA-3
T6750 19923-19929 Protein denotes GATA-3
T6751 19951-19957 Protein denotes GATA-3
T6752 19962-19969 Negative_regulation denotes excised
T6753 19987-19991 Protein denotes XhoI
T6754 20075-20080 Protein denotes BamHI
T6755 20161-20167 Protein denotes GATA-3
T6756 20427-20433 Protein denotes GATA-3
T6757 20451-20454 Protein denotes GFP
T6758 20494-20499 Protein denotes EcoRI
T6759 20533-20539 Protein denotes GATA-3
T6760 20595-20598 Protein denotes GFP
T7349 21208-21218 Gene_expression denotes expressing
T7350 21219-21229 Protein denotes GATA-3-GFP
T8147 23176-23182 Regulation denotes Effect
T8148 23205-23211 Protein denotes GATA-3
T8149 23212-23219 Entity denotes Nuclear
T8150 23220-23233 Localization denotes Translocation
T8151 23238-23242 Protein denotes IL-4
T8152 23281-23291 Negative_regulation denotes inhibiting
T8153 23292-23298 Protein denotes GATA-3
T8154 23299-23308 Regulation denotes regulated true
T8155 23309-23313 Protein denotes IL-4
T8156 23319-23329 Gene_expression denotes expression
T8157 23407-23413 Regulation denotes affect
T8158 23428-23438 Positive_regulation denotes stimulated
T8159 23439-23446 Entity denotes nuclear
T8160 23447-23453 Localization denotes import
T8161 23457-23463 Protein denotes GATA-3
T8162 23505-23513 Positive_regulation denotes resulted
T8163 23537-23544 Entity denotes nuclear
T8164 23545-23551 Protein denotes GATA-3
T8165 23552-23565 Localization denotes translocation
T8166 23720-23725 Protein denotes MEK-1
T8167 23791-23800 Positive_regulation denotes sustained
T8168 23801-23805 Negative_regulation denotes loss
T8169 23809-23816 Entity denotes nuclear
T8170 23817-23823 Protein denotes GATA-3
T8171 23824-23834 Gene_expression denotes expression
T8172 23839-23850 Entity denotes cytoplasmic
T8173 23851-23860 Localization denotes retention
T8174 23864-23870 Protein denotes GATA-3
T8175 24124-24134 Negative_regulation denotes reductions
T8176 24152-24162 Positive_regulation denotes stimulated
T8177 24163-24167 Protein denotes IL-4
T8178 24172-24176 Protein denotes IL-5
T8179 24177-24192 Transcription denotes mRNA expression
T8180 24211-24215 Negative_regulation denotes loss
T8181 24219-24225 Protein denotes GATA-3
T8182 24226-24233 Binding denotes binding
T8183 24248-24252 Protein denotes IL-5
T8184 24253-24261 Entity denotes promoter
T8891 25831-25840 Positive_regulation denotes Activated
T8892 25841-25843 Protein denotes GR
T8893 25858-25864 Protein denotes GATA-3
T8894 25945-25954 Positive_regulation denotes activated
T8895 25955-25957 Protein denotes GR
T8896 25969-25975 Protein denotes GATA-3
T8897 26000-26007 Entity denotes nuclear
T8898 26008-26014 Localization denotes import
T8899 26040-26051 Binding denotes interaction
T8900 26060-26062 Protein denotes GR
T8901 26173-26175 Protein denotes GR
T8902 26176-26183 Entity denotes nuclear
T8903 26184-26197 Localization denotes translocation
T8904 26335-26344 Negative_regulation denotes decreased
T8905 26349-26360 Binding denotes association
T8906 26369-26375 Protein denotes GATA-3
T8907 26391-26398 Positive_regulation denotes induced
T8908 26496-26515 Protein denotes GFP-labelled GATA-3
T8909 26561-26567 Protein denotes GATA-3
T8910 26568-26575 Entity denotes nuclear
T8911 26576-26582 Localization denotes import
T8912 26583-26592 Positive_regulation denotes following
T8913 26634-26644 Negative_regulation denotes attenuated
T9488 28251-28257 Regulation denotes Effect
T9489 28398-28403 Protein denotes MKP-1
T9490 28405-28423 Protein denotes MAPK phosphatase-1
T9491 28629-28644 Phosphorylation denotes phosphorylation
T9492 28670-28675 Protein denotes ATF-2
T9493 28797-28804 Negative_regulation denotes reduced
T9494 28805-28811 Protein denotes GATA-3
T9495 28812-28818 Entity denotes serine
T9496 28819-28834 Phosphorylation denotes phosphorylation
T9497 28835-28842 Positive_regulation denotes induced
T9498 28941-28950 Negative_regulation denotes reduction
T9499 28954-28960 Protein denotes GATA-3
T9500 28961-28976 Phosphorylation denotes phosphorylation
T9501 29055-29062 Positive_regulation denotes induced
T9502 29063-29068 Protein denotes MKP-1
T9503 29201-29208 Regulation denotes effects
T9504 29218-29224 Protein denotes GATA-3
T9505 29225-29232 Entity denotes nuclear
T9506 29233-29239 Localization denotes import
T9507 29252-29263 Binding denotes association
T9508 29268-29272 Protein denotes IL-4
T9509 29273-29288 Transcription denotes mRNA expression
T9510 30735-30744 Positive_regulation denotes activated
T9511 30745-30751 Protein denotes GATA-3
T9512 30769-30778 Positive_regulation denotes activated
T9513 30779-30781 Protein denotes GR
T9514 30804-30813 Positive_regulation denotes activated true
T9515 30814-30816 Protein denotes GR
T9516 30831-30840 Positive_regulation denotes increased
T9517 30841-30843 Protein denotes GR true
T9518 30855-30866 Binding denotes association
T9519 30887-30894 Negative_regulation denotes absence
T9520 30898-30907 Positive_regulation denotes activated
T9521 30908-30914 Protein denotes GATA-3
T9522 30961-30970 Positive_regulation denotes activated
T9523 30971-30977 Protein denotes GATA-3
T9524 30986-30991 Negative_regulation denotes block
T9525 30992-30994 Protein denotes GR
T9526 31006-31017 Binding denotes association
T9527 31065-31074 Positive_regulation denotes activated
T9528 31075-31077 Protein denotes GR true
T9529 31082-31089 Phosphorylation denotes phospho
T9530 31090-31096 Protein denotes GATA-3
T9531 31110-31119 Binding denotes associate
T9532 31157-31166 Positive_regulation denotes activated
T9533 31167-31169 Protein denotes GR
T9534 31170-31180 Negative_regulation denotes attenuates
T9535 31185-31192 Phosphorylation denotes phospho
T9536 31193-31199 Protein denotes GATA-3 true
T9537 31211-31222 Binding denotes interaction
T9538 31242-31251 Regulation denotes dependent
T9539 31308-31317 Positive_regulation denotes activated true
T9540 31318-31320 Protein denotes GR
T9541 31325-31332 Negative_regulation denotes compete true
T9542 31338-31345 Phosphorylation denotes phospho
T9543 31346-31352 Protein denotes GATA-3
T9544 31380-31385 Negative_regulation denotes limit true
T9545 31386-31392 Protein denotes GATA-3
T9546 31393-31400 Entity denotes nuclear
T9547 31401-31407 Localization denotes import
T9548 32560-32566 Regulation denotes effect true
T9549 32576-32582 Protein denotes GATA-3
T9550 32583-32590 Entity denotes nuclear
T9551 32591-32597 Localization denotes export
T9552 32605-32616 Protein_catabolism denotes degradation
T9553 32638-32646 Negative_regulation denotes inhibits
T9554 32655-32661 Localization denotes export
T9555 32671-32677 Regulation denotes affect
T9556 32699-32704 Negative_regulation denotes block
T9557 32705-32711 Protein denotes GATA-3
T9558 32712-32719 Entity denotes nuclear
T9559 32720-32732 Localization denotes localization
T9560 32770-32776 Regulation denotes effect
T9561 32791-32797 Protein denotes GATA-3
T9562 32798-32808 Gene_expression denotes expression
T9563 32917-32924 Entity denotes nuclear
T9564 32925-32938 Localization denotes translocation
T9565 32939-32945 Regulation denotes affect
T9566 32946-32952 Protein denotes GATA-3
T9567 32953-32960 Entity denotes nuclear
T9568 32961-32970 Localization denotes residency
T9569 33000-33009 Positive_regulation denotes activated
T9570 33010-33012 Protein denotes GR
T9571 33022-33029 Positive_regulation denotes enhance
T9572 33030-33036 Protein denotes GATA-3
T9573 33037-33044 Entity denotes nuclear
T9574 33045-33051 Localization denotes export
T9575 33066-33072 Regulation denotes effect
T9576 33082-33088 Protein denotes GATA-3
T9577 33089-33096 Entity denotes nuclear
T9578 33097-33103 Localization denotes import
T9579 33150-33156 Regulation denotes effect
T9580 33160-33163 Protein denotes p65
T9581 33164-33171 Entity denotes nuclear
T9582 33172-33185 Localization denotes translocation
T11160 34284-34290 Regulation denotes Effect
T11161 34313-34319 Protein denotes GATA-3
T11162 34320-34327 Entity denotes Nuclear
T11163 34328-34340 Localization denotes Localization
T11164 34441-34450 Regulation denotes dependent
T11165 34451-34459 Negative_regulation denotes decrease
T11166 34474-34485 Binding denotes interaction
T11167 34494-34501 Phosphorylation denotes phospho
T11168 34502-34508 Protein denotes GATA-3
T11169 34603-34612 Negative_regulation denotes inhibited
T11170 34681-34691 Negative_regulation denotes attenuated
T11171 35753-35763 Negative_regulation denotes suppresses
T11172 35764-35768 Protein denotes IL-4
T11173 35773-35775 Protein denotes -5
T11174 35781-35791 Gene_expression denotes expression
T11175 35796-35806 Negative_regulation denotes attenuated
T11176 35811-35822 Binding denotes interaction
T11177 35826-35832 Protein denotes GATA-3
T11178 36078-36085 Negative_regulation denotes reduced
T11179 36086-36092 Protein denotes GATA-3
T11180 36104-36115 Binding denotes interaction
T11181 36134-36143 Regulation denotes dependent
T11182 36173-36181 Negative_regulation denotes decrease
T11183 36185-36191 Protein denotes GATA-3 true
T11184 36203-36214 Binding denotes association
T11185 36483-36489 Protein denotes GATA-3
T11186 36501-36512 Binding denotes association
T11187 36599-36609 Negative_regulation denotes attenuated
T11188 36610-36621 Binding denotes interaction true
T11189 36625-36631 Protein denotes GATA-3
T11190 36708-36716 Negative_regulation denotes decrease
T11191 36847-36853 Regulation denotes affect
T11192 36863-36875 Localization denotes localization
T11193 36879-36885 Protein denotes GATA-3
T11194 36972-36981 Positive_regulation denotes increased
T11195 36982-36984 Protein denotes GR
T11196 36985-36992 Entity denotes nuclear
T11197 36993-37006 Localization denotes translocation
T11198 37069-37075 Protein denotes GATA-3
T11199 37424-37431 Positive_regulation denotes induced
T11200 37444-37448 Negative_regulation denotes loss
T11201 37460-37466 Protein denotes GATA-3
T11202 37603-37609 Protein denotes GATA-3
T11203 37622-37630 Positive_regulation denotes enhanced
T11204 39467-39474 Negative_regulation denotes reduces
T11205 39475-39482 Entity denotes nuclear
T11206 39483-39495 Localization denotes localization
T11207 39499-39505 Protein denotes GATA-3
T11208 39525-39535 Negative_regulation denotes inhibiting
T11209 39536-39543 Phosphorylation denotes phospho
T11210 39544-39550 Protein denotes GATA-3
T11211 39560-39571 Binding denotes association
T11212 39679-39685 Regulation denotes effect
T11213 39698-39706 Positive_regulation denotes mediated
T11214 39707-39713 Protein denotes GATA-3
T11215 39714-39729 Phosphorylation denotes phosphorylation
T11216 39740-39749 Positive_regulation denotes induction
T11217 39753-39758 Protein denotes MKP-1
T11218 39832-39843 Negative_regulation denotes suppression
T11219 39847-39853 Protein denotes GATA-3
T11220 39854-39861 Entity denotes nuclear
T11221 39862-39868 Localization denotes import
T13008 40009-40016 Negative_regulation denotes inhibit
T13009 40017-40023 Protein denotes GATA-3
T13010 40157-40166 Positive_regulation denotes activated
T13011 40167-40169 Protein denotes GR
T13012 40194-40203 Positive_regulation denotes activated
T13013 40204-40210 Protein denotes GATA-3
T13014 40215-40222 Entity denotes nuclear
T13015 40223-40229 Localization denotes import
T13016 40230-40233 Positive_regulation denotes via
T13017 40255-40263 Positive_regulation denotes required
T13018 40272-40279 Entity denotes nuclear
T13019 40280-40289 Localization denotes transport
T13020 40298-40304 Protein denotes GATA-3
T13021 40309-40311 Protein denotes GR
T13022 40364-40372 Positive_regulation denotes increase
T13023 40377-40387 Gene_expression denotes expression
T13024 40391-40396 Protein denotes MKP-1
T13025 40512-40519 Negative_regulation denotes prevent
T13026 40524-40539 Phosphorylation denotes phosphorylation
T13027 40543-40549 Protein denotes GATA-3
T13028 40558-40567 Positive_regulation denotes necessary
T13029 40572-40583 Binding denotes interaction
T13030 40615-40622 Entity denotes nuclear true
T13031 40623-40629 Localization denotes import
T13032 40661-40674 Localization denotes translocation
T13033 40678-40684 Protein denotes GATA-3
T13034 40711-40718 Entity denotes nucleus
T13035 40719-40727 Positive_regulation denotes involves
T13036 40778-40787 Binding denotes interacts
T13037 40793-40807 Phosphorylation denotes phosphorylated
T13038 40808-40814 Protein denotes GATA-3
T13039 40859-40865 Protein denotes GATA-3
T13040 40866-40875 Negative_regulation denotes knockdown
T13041 40899-40910 Negative_regulation denotes suppression
T13042 40928-40938 Positive_regulation denotes stimulated true
T13043 40939-40943 Protein denotes IL-4
T13044 40944-40948 Protein denotes IL-5
T13045 40949-40953 Transcription denotes mRNA
T13046 40954-40963 Positive_regulation denotes induction
T13047 40995-40999 Regulation denotes role
T13048 41004-41010 Protein denotes GATA-3
T13049 41092-41094 Protein denotes GR true
T13050 41114-41121 Entity denotes nuclear
T13051 41122-41128 Localization denotes import
T13052 41142-41148 Protein denotes GATA-3 true
T13053 41217-41226 Positive_regulation denotes activated
T13054 41227-41229 Protein denotes GR
T13055 41234-41241 Phosphorylation denotes phospho true
T13056 41242-41248 Protein denotes GATA-3
T13057 41253-41260 Entity denotes nuclear true
T13058 41261-41267 Localization denotes import
T13059 41323-41330 Binding denotes binding
T13060 41348-41357 Positive_regulation denotes activated
T13061 41358-41360 Protein denotes GR
T13062 41366-41373 Phosphorylation denotes phospho
T13063 41374-41380 Protein denotes GATA-3
T13064 41427-41433 Negative_regulation denotes reduce
T13065 41434-41440 Protein denotes GATA-3 true
T13066 41441-41446 Binding denotes entry
T13067 41597-41603 Protein denotes GATA-3
T13068 41608-41615 Entity denotes nuclear true
T13069 41616-41629 Localization denotes translocation
T13070 41637-41640 Protein denotes p65
T13071 41666-41674 Regulation denotes affected
T13072 41752-41758 Regulation denotes effect
T13073 41768-41774 Protein denotes GATA-3
T13074 41775-41782 Entity denotes nuclear
T13075 41783-41792 Localization denotes exclusion
T13076 41827-41835 Positive_regulation denotes enhances
T13077 41836-41842 Protein denotes GATA-3
T13078 41843-41850 Entity denotes nuclear
T13079 41851-41857 Localization denotes export true
T13080 41870-41877 Positive_regulation denotes induces
T13081 41878-41884 Protein denotes GATA-3
T13082 41885-41896 Protein_catabolism denotes degradation
T13083 41985-41994 Positive_regulation denotes activated
T13084 41995-41997 Protein denotes GR true true
T13085 42010-42019 Negative_regulation denotes attenuate
T13086 42029-42036 Phosphorylation denotes phospho
T13087 42037-42043 Protein denotes GATA-3
T13088 42055-42066 Binding denotes association
T13089 42142-42149 Phosphorylation denotes phospho
T13090 42150-42156 Protein denotes GATA-3
T13091 42161-42170 Binding denotes associate
T13092 42368-42378 Positive_regulation denotes contribute
T13093 42386-42395 Negative_regulation denotes reduction
T13094 42399-42405 Protein denotes GATA-3
T13095 42406-42413 Entity denotes nuclear
T13096 42414-42420 Localization denotes import
T13097 42521-42526 Protein denotes MKP-1
T13098 42527-42536 Positive_regulation denotes induction
T13099 42597-42606 Positive_regulation denotes induction
T13100 42610-42615 Protein denotes MKP-1
T13101 42698-42707 Positive_regulation denotes induction
T13102 42711-42716 Protein denotes MKP-1
T13103 42722-42731 Positive_regulation denotes following
T13104 42827-42836 Positive_regulation denotes induction
T13105 42840-42845 Protein denotes MKP-1
T13106 42850-42856 Negative_regulation denotes reduce
T13107 42857-42863 Protein denotes GATA-3
T13108 42864-42871 Entity denotes nuclear
T13109 42872-42878 Localization denotes import
T13110 42916-42926 Positive_regulation denotes subsequent
T13111 42927-42933 Protein denotes GATA-3
T13112 42934-42949 Phosphorylation denotes phosphorylation
T13113 42956-42966 Negative_regulation denotes preventing
T13114 42967-42974 Entity denotes nuclear
T13115 42975-42988 Localization denotes translocation
T13116 43010-43024 Entity denotes serine residue
T13117 43031-43037 Protein denotes GATA-3
T13118 43047-43061 Phosphorylation denotes phosphorylated
T13119 43310-43316 Protein denotes GATA-3
T13120 43317-43324 Entity denotes nuclear
T13121 43325-43331 Localization denotes import
T13122 43477-43487 Negative_regulation denotes inhibitory
T13123 43488-43494 Regulation denotes effect
T13124 43508-43518 Gene_expression denotes expression
T13125 43522-43526 Protein denotes IL-4
T13126 43684-43692 Negative_regulation denotes suppress
T13127 43693-43697 Protein denotes IL-4
T13128 43698-43711 Transcription denotes transcription
T13129 43841-43849 Positive_regulation denotes required
T13130 43854-43860 Protein denotes GATA-3
T13131 43861-43871 Negative_regulation denotes inhibition
T13132 43998-44008 Negative_regulation denotes inhibiting
T13133 44009-44015 Protein denotes GATA-3
T13134 44343-44351 Negative_regulation denotes suppress
T13135 44352-44356 Protein denotes IL-4
T13136 44361-44365 Protein denotes IL-5
T13137 44366-44373 Localization denotes release
T13138 44594-44600 Regulation denotes effect
T13139 44604-44610 Protein denotes GATA-3
T13140 44611-44618 Entity denotes nuclear
T13141 44619-44632 Localization denotes translocation
T13142 44649-44656 Binding denotes binding
T13143 44671-44678 Entity denotes nuclear
T13144 44679-44685 Localization denotes import
T13145 44741-44750 Positive_regulation denotes increased
T13146 44751-44760 Gene_expression denotes synthesis
T13147 44764-44769 Protein denotes MKP-1
T13148 44801-44811 Negative_regulation denotes preventing
T13149 44816-44831 Phosphorylation denotes phosphorylation
T13150 44835-44841 Protein denotes GATA-3
T13151 44850-44859 Positive_regulation denotes necessary
T13152 44864-44871 Entity denotes nuclear
T13153 44872-44885 Localization denotes translocation
T13154 44889-44895 Protein denotes GATA-3
T13155 45236-45246 Negative_regulation denotes Prevention
T13156 45250-45257 Phosphorylation denotes phospho
T13157 45258-45264 Protein denotes GATA-3
T13158 45265-45276 Binding denotes interaction
T15975 24390-24398 Negative_regulation denotes inhibits
T15976 24399-24405 Protein denotes GATA-3
T15977 24406-24413 Entity denotes nuclear
T15978 24414-24420 Localization denotes import
T15979 24477-24490 Localization denotes translocation
T15980 24494-24500 Protein denotes GATA-3
T15981 24527-24534 Entity denotes nucleus
T15982 24569-24574 Protein denotes MEK-1
T15983 24749-24757 Negative_regulation denotes impaired
T15984 24758-24765 Entity denotes nuclear
T15985 24766-24778 Localization denotes localization
T15986 24782-24788 Protein denotes GATA-3
T15987 24789-24796 Positive_regulation denotes induced
T15988 24985-24989 Protein denotes MEK1
T15989 25235-25243 Negative_regulation denotes inhibits
T15990 25244-25248 Protein denotes IL-4
T15991 25253-25257 Protein denotes IL-5
T15992 25258-25273 Transcription denotes mRNA expression
T15993 25277-25280 Protein denotes CD3
T15994 25281-25285 Protein denotes CD28
T15995 25553-25560 Negative_regulation denotes reduces
T15996 25590-25600 Positive_regulation denotes stimulated
T15997 25601-25607 Protein denotes GATA-3
T15998 25611-25620 Binding denotes associate
T15999 25637-25641 Protein denotes IL-5
T16765 26758-26765 Negative_regulation denotes reduces
T16766 26766-26772 Protein denotes GATA-3
T16767 26773-26784 Binding denotes association
T16768 26805-26811 Protein denotes GATA-3
T16769 26812-26819 Entity denotes nuclear
T16770 26820-26826 Localization denotes import
T16771 26939-26948 Regulation denotes dependent
T16772 26949-26958 Positive_regulation denotes induction
T16773 26965-26974 Positive_regulation denotes activated
T16774 26975-26977 Protein denotes GR
T16775 26978-26989 Binding denotes interaction
T16776 27038-27040 Protein denotes GR
T16777 27041-27052 Binding denotes association
T16778 27362-27371 Regulation denotes dependent
T16779 27372-27381 Positive_regulation denotes induction
T16780 27388-27397 Positive_regulation denotes activated
T16781 27398-27400 Protein denotes GR
T16782 27401-27408 Entity denotes nuclear
T16783 27409-27422 Localization denotes translocation
T16784 27719-27728 Regulation denotes dependent
T16785 27729-27737 Negative_regulation denotes decrease
T16786 27741-27747 Protein denotes GATA-3
T16787 27759-27770 Binding denotes association
T16788 28009-28015 Protein denotes GATA-3
T17567 29523-29538 Negative_regulation denotes down-regulation
T17568 29542-29548 Protein denotes GATA-3
T17569 29549-29555 Entity denotes serine
T17570 29556-29571 Phosphorylation denotes phosphorylation
T17571 29782-29788 Regulation denotes effect
T17572 29807-29822 Phosphorylation denotes phosphorylation
T17573 29826-29858 Protein denotes activated transcription factor 2
T17574 29860-29865 Protein denotes ATF-2
T17575 30011-30018 Positive_regulation denotes induced
T17576 30019-30025 Entity denotes serine
T17577 30026-30041 Phosphorylation denotes phosphorylation
T17578 30053-30059 Protein denotes GATA-3
T17579 30290-30297 Positive_regulation denotes induced
T17580 30298-30303 Protein denotes MKP-1
T17581 30481-30488 Positive_regulation denotes induces
T17582 30489-30494 Protein denotes MKP-1
T18248 31490-31497 Phosphorylation denotes phospho
T18249 31498-31504 Protein denotes GATA-3
T18250 31597-31599 Protein denotes GR
T18251 31643-31651 Positive_regulation denotes enhances
T18252 31652-31654 Protein denotes GR true
T18253 31666-31673 Binding denotes binding
T18254 31698-31705 Negative_regulation denotes absence
T18255 31713-31722 Positive_regulation denotes activated
T18256 31723-31729 Protein denotes GATA-3
T18257 31755-31764 Positive_regulation denotes activated
T18258 31765-31767 Protein denotes GR
T18259 31773-31779 Protein denotes GATA-3
T18260 31834-31843 Negative_regulation denotes attenuate
T18261 31844-31846 Protein denotes GR true
T18262 31858-31869 Binding denotes association
T18263 31904-31913 Positive_regulation denotes Activated
T18264 31914-31916 Protein denotes GR
T18265 31956-31962 Protein denotes GATA-3
T18266 32008-32019 Binding denotes interacting
T18267 32098-32104 Protein denotes GATA-3
T18268 32160-32170 Positive_regulation denotes stimulated
T18269 32171-32177 Protein denotes GATA-3
T18270 32187-32194 Binding denotes binding
T18271 32204-32210 Regulation denotes effect
T18272 32214-32223 Positive_regulation denotes activated
T18273 32252-32254 Protein denotes GR
T18274 32258-32269 Negative_regulation denotes attenuation
T18275 32273-32279 Protein denotes GATA-3
T18276 32291-32302 Binding denotes association
T18277 32321-32330 Regulation denotes dependent
T18676 33294-33300 Regulation denotes affect true
T18677 33301-33307 Protein denotes GATA-3
T18678 33308-33315 Entity denotes nuclear true
T18679 33316-33322 Localization denotes export
T18680 33421-33427 Regulation denotes affect
T18681 33458-33465 Negative_regulation denotes prevent
T18682 33480-33490 Positive_regulation denotes stimulated true
T18683 33491-33497 Protein denotes GATA-3
T18684 33498-33505 Entity denotes nuclear true
T18685 33506-33518 Localization denotes localization
T18686 33698-33704 Regulation denotes affect
T18687 33716-33722 Protein denotes GATA-3
T18688 33723-33734 Protein_catabolism denotes degradation
T18689 33761-33767 Protein denotes GATA-3
T18690 33978-33985 Negative_regulation denotes prevent
T18691 34000-34010 Positive_regulation denotes stimulated
T18692 34011-34014 Protein denotes p65
T18693 34015-34022 Entity denotes nuclear
T18694 34023-34036 Localization denotes translocation
T19261 34812-34819 Negative_regulation denotes impairs
T19262 34820-34826 Protein denotes GATA-3
T19263 34827-34838 Binding denotes interaction
T19264 34859-34865 Protein denotes GATA-3
T19265 34866-34873 Entity denotes nuclear
T19266 34874-34886 Localization denotes localization
T19267 35032-35040 Negative_regulation denotes impaired
T19268 35041-35052 Binding denotes interaction
T19269 35061-35067 Protein denotes GATA-3
T19270 35412-35421 Negative_regulation denotes decreased
T19271 35422-35433 Binding denotes association
T19272 35442-35448 Protein denotes GATA-3
T19670 38007-38014 Negative_regulation denotes impairs
T19671 38015-38021 Protein denotes GATA-3
T19672 38022-38029 Entity denotes nuclear
T19673 38030-38042 Localization denotes localization
T19674 38140-38142 Protein denotes GR
T19675 38147-38153 Protein denotes GATA-3
T19676 38154-38161 Entity denotes nuclear
T19677 38162-38174 Localization denotes localisation
T19678 38188-38194 Protein denotes GATA-3
T19679 38540-38549 Regulation denotes dependent
T19680 38550-38558 Negative_regulation denotes decrease
T19681 38562-38569 Entity denotes nuclear
T19682 38570-38580 Gene_expression denotes expression
T19683 38584-38590 Protein denotes GATA-3
T19684 38596-38605 Positive_regulation denotes increased
T19685 38606-38617 Entity denotes cytoplasmic
T19686 38618-38624 Protein denotes GATA-3
T19687 38625-38635 Gene_expression denotes expression
T19688 38717-38726 Regulation denotes dependent
T19689 38727-38735 Negative_regulation denotes decrease
T19690 38739-38746 Entity denotes nuclear
T19691 38747-38757 Gene_expression denotes expression
T19692 38761-38767 Protein denotes GATA-3
T19693 38773-38782 Positive_regulation denotes increased
T19694 38783-38794 Entity denotes cytoplasmic
T19695 38795-38801 Protein denotes GATA-3
T19696 38802-38812 Gene_expression denotes expression
T19697 38856-38861 Protein denotes MEK-1
R59 T72 T71 themeOf glucocorticoid receptor,activated
R60 T74 T73 themeOf expression,induces
R61 T74 T77 causeOf expression,necessary
R62 T75 T74 themeOf mitogen-activated protein kinase (MAPK) phosphatase-1,expression
R63 T76 T75 equivalentTo MKP-1,mitogen-activated protein kinase (MAPK) phosphatase-1
R64 T78 T80 themeOf GATA-3,translocation
R65 T79 T80 locationOf nuclear,translocation
R66 T80 T77 themeOf translocation,necessary
R67 T82 T84 themeOf GATA-3,translocation
R68 T83 T84 locationOf nuclear,translocation
R69 T84 T81 themeOf translocation,inhibits
R70 T86 T85 themeOf GATA-3,inhibitory effect
R38 T48 T51 themeOf GATA-3,Phosphorylation
R39 T49 T50 locationOf Nuclear,Import
R40 T50 T47 themeOf Import,Suppression
R41 T51 T47 themeOf Phosphorylation,Suppression
R42 T52 T54 causeOf GATA-3,regulating
R43 T52 T53 causeOf GATA-3,role
R44 T55 T54 themeOf expression,regulating
R45 T56 T55 themeOf interleukin (IL)-4,expression
R46 T57 T55 themeOf IL-5,expression
R47 T58 T55 themeOf IL-13,expression
R48 T60 T59 themeOf GATA-3,effects
R49 T61 T62 themeOf GATA-3,regulation
R50 T63 T68 themeOf inhibits,independent
R51 T64 T65 locationOf nuclear,translocation
R52 T65 T68 themeOf translocation,independent
R53 T65 T63 themeOf translocation,inhibits
R54 T66 T67 themeOf GATA-3,expression
R55 T67 T63 themeOf expression,inhibits
R56 T67 T68 themeOf expression,independent
R57 T70 T71 themeOf GATA-3,activated
R58 T70 T69 themeOf GATA-3,competition
R889 T1072 T1071 themeOf interleukin (IL)-4,expression
R890 T1073 T1071 themeOf IL-5,expression
R891 T1074 T1071 themeOf IL-13,expression
R892 T1078 T1077 themeOf expression,regulate
R893 T1081 T1082 themeOf GATA-3,expressed
R894 T1083 T1084 causeOf GATA-3,activates
R895 T1085 T1084 themeOf promoters,activates
R896 T1085 T1087 partOf promoters,IL-5
R897 T1085 T1088 partOf promoters,IL-13
R898 T1085 T1086 partOf promoters,IL-4
R899 T1096 T1097 themeOf GATA-3,expression
R900 T1097 T1095 themeOf expression,knockdown
R901 T1098 T1099 themeOf GATA-3,translocate
R902 T1100 T1099 locationOf nucleus,translocate
R903 T1102 T1103 locationOf nuclear,expression
R904 T1103 T1101 themeOf expression,Enhanced
R905 T1103 T1105 themeOf expression,following
R906 T1104 T1103 themeOf GATA-3,expression
R907 T1107 T1108 themeOf GATA-3,import
R908 T1107 T1110 themeOf GATA-3,import
R909 T1109 T1108 locationOf nucleus,import
R910 T1115 T1114 themeOf phosphorylating,role
R911 T1116 T1115 themeOf GATA-3,phosphorylating
R912 T1116 T1117 causeOf GATA-3,enhance
R913 T1116 T1118 themeOf GATA-3,interaction
R914 T1118 T1117 themeOf interaction,enhance
R915 T1120 T1119 themeOf glucocorticoid receptors,binding
R916 T1120 T1124 themeOf glucocorticoid receptors,interact
R917 T1120 T1122 themeOf glucocorticoid receptors,translocate
R918 T1121 T1120 equivalentTo GRs,glucocorticoid receptors
R919 T1123 T1122 locationOf nucleus,translocate
R920 T1126 T1127 themeOf GR,interacts
R921 T1126 T1128 themeOf GR,recruitment
R922 T1126 T1125 themeOf GR,activated
R923 T1129 T1128 themeOf histone deacetylase-2,recruitment
R924 T1130 T1131 locationOf Nuclear,localisation
R925 T1131 T1134 themeOf localisation,mediated
R926 T1132 T1134 themeOf retention,mediated
R927 T1133 T1131 themeOf GR,localisation
R928 T1133 T1137 themeOf GR,export
R929 T1133 T1132 themeOf GR,retention
R930 T1133 T1135 themeOf GR,retention
R931 T1136 T1137 locationOf nuclear,export
R932 T1139 T1138 equivalentTo CRM-1,chromosomal region maintenance 1
R933 T1142 T1146 themeOf GR,interaction
R934 T1142 T1143 themeOf GR,translocates
R935 T1143 T1145 themeOf translocates,in response to
R936 T1143 T1141 themeOf translocates,resulting
R937 T1144 T1143 locationOf nucleus,translocates
R938 T1146 T1145 causeOf interaction,in response to
R939 T1147 T1146 themeOf importin 7,interaction
R940 T1148 T1149 themeOf GR,import
R941 T1151 T1154 themeOf GR,import
R942 T1151 T1155 themeOf GR,binding
R943 T1151 T1152 themeOf GR,activation
R944 T1152 T1150 themeOf activation,regulation
R945 T1153 T1154 locationOf nuclear,import
R946 T1154 T1150 themeOf import,regulation
R947 T1155 T1150 themeOf binding,regulation
R948 T1160 T1161 causeOf GR,reduced
R949 T1162 T1163 causeOf GATA-3,mediated
R950 T1163 T1161 themeOf mediated,reduced
R951 T1167 T1169 causeOf recruitment,alter
R952 T1168 T1167 themeOf GR,recruitment
R953 T1170 T1172 themeOf GATA-3,up-regulation
R954 T1170 T1171 themeOf GATA-3,bind
R955 T1173 T1174 themeOf GATA-3,phosphorylation
R956 T1173 T1176 themeOf GATA-3,translocation
R957 T1175 T1176 locationOf nuclear,translocation
R958 T1177 T1178 themeOf GATA-3,localization
R5811 T6751 T6752 themeOf GATA-3,excised
R5812 T6756 T6758 themeOf GATA-3,EcoRI
R5813 T6757 T6758 themeOf GFP,EcoRI
R5814 T6759 T6758 themeOf GATA-3,EcoRI
R6292 T7350 T7349 themeOf GATA-3-GFP,expressing
R7047 T8148 T8150 themeOf GATA-3,Translocation
R7048 T8149 T8150 locationOf Nuclear,Translocation
R7049 T8150 T8147 themeOf Translocation,Effect
R7050 T8151 T8147 themeOf IL-4,Effect
R7051 T8153 T8154 causeOf GATA-3,regulated
R7052 T8154 T8152 themeOf regulated,inhibiting
R7053 T8155 T8156 themeOf IL-4,expression
R7054 T8156 T8154 themeOf expression,regulated
R7055 T8159 T8160 locationOf nuclear,import
R7056 T8160 T8158 themeOf import,stimulated
R7057 T8161 T8160 themeOf GATA-3,import
R7058 T8163 T8165 locationOf nuclear,translocation
R7059 T8164 T8165 themeOf GATA-3,translocation
R7060 T8165 T8162 themeOf translocation,resulted
R7061 T8168 T8167 themeOf loss,sustained
R7062 T8169 T8171 locationOf nuclear,expression
R7063 T8170 T8171 themeOf GATA-3,expression
R7064 T8171 T8168 themeOf expression,loss
R7065 T8172 T8173 locationOf cytoplasmic,retention
R7066 T8173 T8168 themeOf retention,loss
R7067 T8174 T8173 themeOf GATA-3,retention
R7068 T8177 T8179 themeOf IL-4,mRNA expression
R7069 T8178 T8179 themeOf IL-5,mRNA expression
R7070 T8179 T8176 themeOf mRNA expression,stimulated
R7071 T8181 T8182 themeOf GATA-3,binding
R7072 T8182 T8180 themeOf binding,loss
R7073 T8184 T8182 themeOf promoter,binding
R7074 T8184 T8183 partOf promoter,IL-5
R7665 T8892 T8891 themeOf GR,Activated
R7666 T8895 T8894 themeOf GR,activated
R7667 T8895 T8898 themeOf GR,import
R7668 T8896 T8898 themeOf GATA-3,import
R7669 T8897 T8898 locationOf nuclear,import
R7670 T8900 T8899 themeOf GR,interaction
R7671 T8901 T8903 themeOf GR,translocation
R7672 T8902 T8903 locationOf nuclear,translocation
R7673 T8905 T8904 themeOf association,decreased
R7674 T8905 T8907 themeOf association,induced
R7675 T8906 T8907 themeOf GATA-3,induced
R7676 T8906 T8905 themeOf GATA-3,association
R7677 T8907 T8904 themeOf induced,decreased
R7678 T8909 T8911 themeOf GATA-3,import
R7679 T8910 T8911 locationOf nuclear,import
R7680 T8911 T8912 themeOf import,following
R7681 T8911 T8913 themeOf import,attenuated
R7682 T8912 T8913 themeOf following,attenuated
R8156 T9490 T9489 equivalentTo MAPK phosphatase-1,MKP-1
R8157 T9492 T9491 themeOf ATF-2,phosphorylation
R8158 T9495 T9496 themeOf serine,phosphorylation
R8159 T9495 T9494 partOf serine,GATA-3
R8160 T9496 T9497 themeOf phosphorylation,induced
R8161 T9496 T9493 themeOf phosphorylation,reduced
R8162 T9499 T9500 themeOf GATA-3,phosphorylation
R8163 T9500 T9498 themeOf phosphorylation,reduction
R8164 T9502 T9501 themeOf MKP-1,induced
R8165 T9504 T9509 themeOf GATA-3,mRNA expression
R8166 T9504 T9507 themeOf GATA-3,association
R8167 T9504 T9506 themeOf GATA-3,import
R8168 T9505 T9506 locationOf nuclear,import
R8169 T9505 T9509 locationOf nuclear,mRNA expression
R8170 T9506 T9503 themeOf import,effects
R8171 T9507 T9503 themeOf association,effects
R8172 T9508 T9509 themeOf IL-4,mRNA expression
R8173 T9509 T9503 themeOf mRNA expression,effects
R8174 T9511 T9510 themeOf GATA-3,activated
R8175 T9513 T9512 themeOf GR,activated
R8176 T9515 T9514 themeOf GR,activated
R8177 T9515 T9516 causeOf GR,increased
R8178 T9517 T9518 themeOf GR,association
R8179 T9518 T9516 themeOf association,increased
R8180 T9521 T9520 themeOf GATA-3,activated
R8181 T9523 T9524 causeOf GATA-3,block
R8182 T9523 T9522 themeOf GATA-3,activated
R8183 T9525 T9526 themeOf GR,association
R8184 T9526 T9524 themeOf association,block
R8185 T9528 T9531 themeOf GR,associate
R8186 T9528 T9527 themeOf GR,activated
R8187 T9530 T9529 themeOf GATA-3,phospho
R8188 T9530 T9531 themeOf GATA-3,associate
R8189 T9533 T9532 themeOf GR,activated
R8190 T9533 T9534 causeOf GR,attenuates
R8191 T9534 T9538 themeOf attenuates,dependent
R8192 T9535 T9534 themeOf phospho,attenuates
R8193 T9536 T9537 themeOf GATA-3,interaction
R8194 T9536 T9535 themeOf GATA-3,phospho
R8195 T9537 T9534 themeOf interaction,attenuates
R8196 T9540 T9544 causeOf GR,limit
R8197 T9540 T9539 themeOf GR,activated
R8198 T9540 T9541 causeOf GR,compete
R8199 T9542 T9541 themeOf phospho,compete
R8200 T9543 T9542 themeOf GATA-3,phospho
R8201 T9545 T9547 themeOf GATA-3,import
R8202 T9546 T9547 locationOf nuclear,import
R8203 T9547 T9544 themeOf import,limit
R8204 T9549 T9552 themeOf GATA-3,degradation
R8205 T9549 T9551 themeOf GATA-3,export
R8206 T9550 T9551 locationOf nuclear,export
R8207 T9551 T9548 themeOf export,effect
R8208 T9552 T9548 themeOf degradation,effect
R8209 T9554 T9553 themeOf export,inhibits
R8210 T9557 T9559 themeOf GATA-3,localization
R8211 T9558 T9559 locationOf nuclear,localization
R8212 T9559 T9556 themeOf localization,block
R8213 T9561 T9562 themeOf GATA-3,expression
R8214 T9562 T9560 themeOf expression,effect
R8215 T9563 T9564 locationOf nuclear,translocation
R8216 T9566 T9568 themeOf GATA-3,residency
R8217 T9567 T9568 locationOf nuclear,residency
R8218 T9568 T9565 themeOf residency,affect
R8219 T9570 T9571 causeOf GR,enhance
R8220 T9570 T9569 themeOf GR,activated
R8221 T9572 T9574 themeOf GATA-3,export
R8222 T9573 T9574 locationOf nuclear,export
R8223 T9574 T9571 themeOf export,enhance
R8224 T9576 T9578 themeOf GATA-3,import
R8225 T9577 T9578 locationOf nuclear,import
R8226 T9578 T9575 themeOf import,effect
R8227 T9580 T9582 themeOf p65,translocation
R8228 T9581 T9582 locationOf nuclear,translocation
R8229 T9582 T9579 themeOf translocation,effect
R9548 T11161 T11163 themeOf GATA-3,Localization
R9549 T11162 T11163 locationOf Nuclear,Localization
R9550 T11163 T11160 themeOf Localization,Effect
R9551 T11166 T11165 themeOf interaction,decrease
R9552 T11166 T11170 themeOf interaction,attenuated
R9553 T11166 T11169 themeOf interaction,inhibited
R9554 T11167 T11170 themeOf phospho,attenuated
R9555 T11167 T11169 themeOf phospho,inhibited
R9556 T11168 T11166 themeOf GATA-3,interaction
R9557 T11168 T11167 themeOf GATA-3,phospho
R9558 T11172 T11174 themeOf IL-4,expression
R9559 T11173 T11174 themeOf -5,expression
R9560 T11174 T11171 themeOf expression,suppresses
R9561 T11176 T11175 themeOf interaction,attenuated
R9562 T11177 T11176 themeOf GATA-3,interaction
R9563 T11178 T11181 themeOf reduced,dependent
R9564 T11179 T11180 themeOf GATA-3,interaction
R9565 T11180 T11178 themeOf interaction,reduced
R9566 T11183 T11184 themeOf GATA-3,association
R9567 T11184 T11182 themeOf association,decrease
R9568 T11185 T11186 themeOf GATA-3,association
R9569 T11187 T11190 themeOf attenuated,decrease
R9570 T11188 T11187 themeOf interaction,attenuated
R9571 T11188 T11190 themeOf interaction,decrease
R9572 T11189 T11188 themeOf GATA-3,interaction
R9573 T11192 T11191 themeOf localization,affect
R9574 T11193 T11192 themeOf GATA-3,localization
R9575 T11195 T11197 themeOf GR,translocation
R9576 T11196 T11197 locationOf nuclear,translocation
R9577 T11197 T11194 themeOf translocation,increased
R9578 T11200 T11199 themeOf loss,induced
R9579 T11200 T11203 themeOf loss,enhanced
R9580 T11201 T11200 themeOf GATA-3,loss
R9581 T11202 T11203 themeOf GATA-3,enhanced
R9582 T11202 T11200 themeOf GATA-3,loss
R9583 T11205 T11206 locationOf nuclear,localization
R9584 T11206 T11204 themeOf localization,reduces
R9585 T11207 T11206 themeOf GATA-3,localization
R9586 T11208 T11204 causeOf inhibiting,reduces
R9587 T11209 T11208 themeOf phospho,inhibiting
R9588 T11210 T11211 themeOf GATA-3,association
R9589 T11211 T11208 themeOf association,inhibiting
R9590 T11214 T11215 themeOf GATA-3,phosphorylation
R9591 T11215 T11213 themeOf phosphorylation,mediated
R9592 T11217 T11216 themeOf MKP-1,induction
R9593 T11219 T11221 themeOf GATA-3,import
R9594 T11220 T11221 locationOf nuclear,import
R9595 T11221 T11218 themeOf import,suppression
R11178 T13009 T13008 themeOf GATA-3,inhibit
R11179 T13011 T13010 themeOf GR,activated
R11180 T13013 T13015 themeOf GATA-3,import
R11181 T13014 T13015 locationOf nuclear,import
R11182 T13015 T13016 themeOf import,via
R11183 T13018 T13019 locationOf nuclear,transport
R11184 T13019 T13017 themeOf transport,required
R11185 T13020 T13019 themeOf GATA-3,transport
R11186 T13021 T13019 themeOf GR,transport
R11187 T13023 T13022 themeOf expression,increase
R11188 T13024 T13023 themeOf MKP-1,expression
R11189 T13026 T13028 causeOf phosphorylation,necessary
R11190 T13026 T13025 themeOf phosphorylation,prevent
R11191 T13027 T13029 themeOf GATA-3,interaction
R11192 T13027 T13031 themeOf GATA-3,import
R11193 T13027 T13026 themeOf GATA-3,phosphorylation
R11194 T13029 T13028 themeOf interaction,necessary
R11195 T13030 T13031 locationOf nuclear,import
R11196 T13031 T13028 themeOf import,necessary
R11197 T13032 T13035 themeOf translocation,involves
R11198 T13033 T13032 themeOf GATA-3,translocation
R11199 T13034 T13032 locationOf nucleus,translocation
R11200 T13038 T13037 themeOf GATA-3,phosphorylated
R11201 T13038 T13036 themeOf GATA-3,interacts
R11202 T13039 T13040 themeOf GATA-3,knockdown
R11203 T13040 T13041 causeOf knockdown,suppression
R11204 T13043 T13046 themeOf IL-4,induction
R11205 T13046 T13042 themeOf induction,stimulated
R11206 T13048 T13047 causeOf GATA-3,role
R11207 T13049 T13051 themeOf GR,import
R11208 T13050 T13051 locationOf nuclear,import
R11209 T13054 T13058 themeOf GR,import
R11210 T13054 T13053 themeOf GR,activated
R11211 T13056 T13058 themeOf GATA-3,import
R11212 T13056 T13055 themeOf GATA-3,phospho
R11213 T13057 T13058 locationOf nuclear,import
R11214 T13061 T13060 themeOf GR,activated
R11215 T13063 T13062 themeOf GATA-3,phospho
R11216 T13065 T13066 themeOf GATA-3,entry
R11217 T13065 T13064 themeOf GATA-3,reduce
R11218 T13066 T13064 themeOf entry,reduce
R11219 T13068 T13069 locationOf nuclear,translocation
R11220 T13069 T13071 themeOf translocation,affected
R11221 T13070 T13069 themeOf p65,translocation
R11222 T13073 T13075 themeOf GATA-3,exclusion
R11223 T13074 T13075 locationOf nuclear,exclusion
R11224 T13075 T13072 themeOf exclusion,effect
R11225 T13077 T13079 themeOf GATA-3,export
R11226 T13078 T13079 locationOf nuclear,export
R11227 T13079 T13076 themeOf export,enhances
R11228 T13081 T13082 themeOf GATA-3,degradation
R11229 T13082 T13080 themeOf degradation,induces
R11230 T13084 T13085 causeOf GR,attenuate
R11231 T13084 T13083 themeOf GR,activated
R11232 T13086 T13085 themeOf phospho,attenuate
R11233 T13087 T13088 themeOf GATA-3,association
R11234 T13088 T13085 themeOf association,attenuate
R11235 T13090 T13089 themeOf GATA-3,phospho
R11236 T13090 T13091 themeOf GATA-3,associate
R11237 T13093 T13092 themeOf reduction,contribute
R11238 T13094 T13096 themeOf GATA-3,import
R11239 T13095 T13096 locationOf nuclear,import
R11240 T13096 T13093 themeOf import,reduction
R11241 T13097 T13098 themeOf MKP-1,induction
R11242 T13098 T13093 themeOf induction,reduction
R11243 T13100 T13099 themeOf MKP-1,induction
R11244 T13101 T13103 themeOf induction,following
R11245 T13102 T13101 themeOf MKP-1,induction
R11246 T13105 T13104 themeOf MKP-1,induction
R11247 T13107 T13115 themeOf GATA-3,translocation
R11248 T13107 T13109 themeOf GATA-3,import
R11249 T13108 T13109 locationOf nuclear,import
R11250 T13109 T13106 themeOf import,reduce
R11251 T13111 T13115 themeOf GATA-3,translocation
R11252 T13111 T13112 themeOf GATA-3,phosphorylation
R11253 T13112 T13113 causeOf phosphorylation,preventing
R11254 T13112 T13110 themeOf phosphorylation,subsequent
R11255 T13114 T13115 locationOf nuclear,translocation
R11256 T13115 T13113 themeOf translocation,preventing
R11257 T13116 T13118 themeOf serine residue,phosphorylated
R11258 T13116 T13117 partOf serine residue,GATA-3
R11259 T13119 T13121 themeOf GATA-3,import
R11260 T13120 T13121 locationOf nuclear,import
R11261 T13125 T13124 themeOf IL-4,expression
R11262 T13127 T13128 themeOf IL-4,transcription
R11263 T13128 T13126 themeOf transcription,suppress
R11264 T13130 T13131 themeOf GATA-3,inhibition
R11265 T13131 T13129 themeOf inhibition,required
R11266 T13133 T13132 themeOf GATA-3,inhibiting
R11267 T13135 T13137 themeOf IL-4,release
R11268 T13136 T13137 themeOf IL-5,release
R11269 T13137 T13134 themeOf release,suppress
R11270 T13139 T13144 themeOf GATA-3,import
R11271 T13139 T13141 themeOf GATA-3,translocation
R11272 T13140 T13141 locationOf nuclear,translocation
R11273 T13141 T13138 themeOf translocation,effect
R11274 T13143 T13144 locationOf nuclear,import
R11275 T13146 T13145 themeOf synthesis,increased
R11276 T13147 T13146 themeOf MKP-1,synthesis
R11277 T13149 T13151 causeOf phosphorylation,necessary
R11278 T13149 T13148 themeOf phosphorylation,preventing
R11279 T13150 T13149 themeOf GATA-3,phosphorylation
R11280 T13152 T13153 locationOf nuclear,translocation
R11281 T13153 T13151 themeOf translocation,necessary
R11282 T13154 T13153 themeOf GATA-3,translocation
R11283 T13156 T13155 themeOf phospho,Prevention
R11284 T13157 T13156 themeOf GATA-3,phospho
R11285 T13157 T13158 themeOf GATA-3,interaction
R11286 T13158 T13155 themeOf interaction,Prevention
R13720 T15976 T15978 themeOf GATA-3,import
R13721 T15977 T15978 locationOf nuclear,import
R13722 T15978 T15975 themeOf import,inhibits
R13723 T15980 T15979 themeOf GATA-3,translocation
R13724 T15981 T15979 locationOf nucleus,translocation
R13725 T15984 T15985 locationOf nuclear,localization
R13726 T15985 T15983 themeOf localization,impaired
R13727 T15985 T15987 themeOf localization,induced
R13728 T15986 T15985 themeOf GATA-3,localization
R13729 T15987 T15983 themeOf induced,impaired
R13730 T15990 T15992 themeOf IL-4,mRNA expression
R13731 T15991 T15992 themeOf IL-5,mRNA expression
R13732 T15992 T15989 themeOf mRNA expression,inhibits
R13733 T15996 T15995 themeOf stimulated,reduces
R13734 T15997 T15998 themeOf GATA-3,associate
R13735 T15997 T15996 themeOf GATA-3,stimulated
R13736 T15998 T15995 themeOf associate,reduces
R14371 T16766 T16767 themeOf GATA-3,association
R14372 T16767 T16765 themeOf association,reduces
R14373 T16768 T16770 themeOf GATA-3,import
R14374 T16769 T16770 locationOf nuclear,import
R14375 T16770 T16765 themeOf import,reduces
R14376 T16772 T16771 themeOf induction,dependent
R14377 T16773 T16772 themeOf activated,induction
R14378 T16774 T16773 themeOf GR,activated
R14379 T16774 T16775 themeOf GR,interaction
R14380 T16775 T16772 themeOf interaction,induction
R14381 T16776 T16777 themeOf GR,association
R14382 T16779 T16778 themeOf induction,dependent
R14383 T16780 T16779 themeOf activated,induction
R14384 T16781 T16780 themeOf GR,activated
R14385 T16781 T16783 themeOf GR,translocation
R14386 T16782 T16783 locationOf nuclear,translocation
R14387 T16783 T16779 themeOf translocation,induction
R14388 T16785 T16784 themeOf decrease,dependent
R14389 T16786 T16787 themeOf GATA-3,association
R14390 T16787 T16785 themeOf association,decrease
R15068 T17569 T17568 partOf serine,GATA-3
R15069 T17569 T17567 themeOf serine,down-regulation
R15070 T17569 T17570 themeOf serine,phosphorylation
R15071 T17570 T17567 themeOf phosphorylation,down-regulation
R15072 T17573 T17572 themeOf activated transcription factor 2,phosphorylation
R15073 T17574 T17573 equivalentTo ATF-2,activated transcription factor 2
R15074 T17576 T17577 themeOf serine,phosphorylation
R15075 T17576 T17578 partOf serine,GATA-3
R15076 T17577 T17575 themeOf phosphorylation,induced
R15077 T17580 T17579 themeOf MKP-1,induced
R15078 T17582 T17581 themeOf MKP-1,induces
R15626 T18249 T18248 themeOf GATA-3,phospho
R15627 T18250 T18251 causeOf GR,enhances
R15628 T18252 T18253 themeOf GR,binding
R15629 T18253 T18251 themeOf binding,enhances
R15630 T18256 T18255 themeOf GATA-3,activated
R15631 T18258 T18257 themeOf GR,activated
R15632 T18259 T18260 causeOf GATA-3,attenuate
R15633 T18261 T18262 themeOf GR,association
R15634 T18262 T18260 themeOf association,attenuate
R15635 T18264 T18263 themeOf GR,Activated
R15636 T18264 T18266 themeOf GR,interacting
R15637 T18265 T18266 themeOf GATA-3,interacting
R15638 T18269 T18270 themeOf GATA-3,binding
R15639 T18270 T18268 themeOf binding,stimulated
R15640 T18273 T18272 themeOf GR,activated
R15641 T18273 T18274 causeOf GR,attenuation
R15642 T18274 T18277 themeOf attenuation,dependent
R15643 T18275 T18276 themeOf GATA-3,association
R15644 T18276 T18274 themeOf association,attenuation
R15947 T18677 T18679 themeOf GATA-3,export
R15948 T18678 T18679 locationOf nuclear,export
R15949 T18679 T18676 themeOf export,affect
R15950 T18682 T18681 themeOf stimulated,prevent
R15951 T18683 T18685 themeOf GATA-3,localization
R15952 T18684 T18685 locationOf nuclear,localization
R15953 T18685 T18681 themeOf localization,prevent
R15954 T18685 T18682 themeOf localization,stimulated
R15955 T18687 T18688 themeOf GATA-3,degradation
R15956 T18688 T18686 themeOf degradation,affect
R15957 T18691 T18690 themeOf stimulated,prevent
R15958 T18692 T18694 themeOf p65,translocation
R15959 T18693 T18694 locationOf nuclear,translocation
R15960 T18694 T18691 themeOf translocation,stimulated
R15961 T18694 T18690 themeOf translocation,prevent
R16440 T19262 T19263 themeOf GATA-3,interaction
R16441 T19263 T19261 themeOf interaction,impairs
R16442 T19264 T19266 themeOf GATA-3,localization
R16443 T19265 T19266 locationOf nuclear,localization
R16444 T19266 T19261 themeOf localization,impairs
R16445 T19268 T19267 themeOf interaction,impaired
R16446 T19269 T19268 themeOf GATA-3,interaction
R16447 T19271 T19270 themeOf association,decreased
R16448 T19272 T19271 themeOf GATA-3,association
R16798 T19671 T19673 themeOf GATA-3,localization
R16799 T19672 T19673 locationOf nuclear,localization
R16800 T19673 T19670 themeOf localization,impairs
R16801 T19674 T19677 themeOf GR,localisation
R16802 T19675 T19677 themeOf GATA-3,localisation
R16803 T19676 T19677 locationOf nuclear,localisation
R16804 T19681 T19682 locationOf nuclear,expression
R16809 T19687 T19684 themeOf expression,increased
R37 T48 T50 themeOf GATA-3,Import
R3729 T4345 T4346 themeOf GATA-3,localization
R16805 T19682 T19680 themeOf expression,decrease
R16806 T19683 T19682 themeOf GATA-3,expression
R16807 T19685 T19687 locationOf cytoplasmic,expression
R16808 T19686 T19687 themeOf GATA-3,expression
R16810 T19690 T19691 locationOf nuclear,expression
R16811 T19691 T19689 themeOf expression,decrease
R16812 T19692 T19691 themeOf GATA-3,expression
R16813 T19694 T19696 locationOf cytoplasmic,expression
R16814 T19695 T19696 themeOf GATA-3,expression
R16815 T19696 T19693 themeOf expression,increased