PMC:2669177 / 24025-25169 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/2669177","sourcedb":"PMC","sourceid":"2669177","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2669177","text":"In order to determine the extent of these structural improvements, we undertook a series of morphometric analyses of the nanoparticle injected-eyes compared to controls. Histological images were collected from each eye at 200 µm, 400 µm, and 600 µm from the optic nerve head (both temporally and nasally) and vertical rows of ONL nuclei and OS thickness were measured. Figure S4 shows results from two representative experimental animals, with the average values (± standard deviation) obtained from uninjected control eyes shaded in gray (accompanying supplemental methods found in Text S1). At PI-30, injected animals showed little or no increase in the number of rows in the ONL (top panels), but a definite increase in OS thickness (bottom panels). At PI-120, there was no morphometric evidence of any histological benefit from the CBA-NMP nanoparticles, while IRBP-NMP nanoparticles led to a slight increase in both the number of rows in the ONL and in OS thickness. The increase in ONL rows at PI-120 is particularly relevant, since it suggests that nanoparticle-mediated increases in RDS may slow photoreceptor cell death in the rds +/−.","tracks":[]}