PMC:2668061 / 7347-9051 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2668061","sourcedb":"PMC","sourceid":"2668061","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2668061","text":"Previous genetic studies of the Iberian Peninsula included analyses of classical marker frequencies,27–30 autosomal Alu insertion polymorphisms,31 mitochondrial DNA variation,32,33 and Y-chromosomal haplotypes.34–39 In general, these surveys have paid little attention to the issue of admixture, though studies that include North African populations identify a marked genetic boundary coinciding with the Gibraltar Strait.30–32,34,36 The Y chromosome provides the phylogeographic resolution that might allow the disentangling of past admixture events,40 and studies34,36,38,41,42 have focused on haplogroup E3b2 (also known as E-M81), common in North Africa and found at an average frequency of 5.6% in the peninsula,38 which, adjusting for the haplogroup's frequency in North Africa itself, would correspond to a contribution of 8%–9%. Although these studies indicate the presence of some North African lineages in the Iberian Peninsula, they have taken ad hoc approaches to quantifying this and have almost entirely41 neglected to address the possible contribution of Sephardic Jews. Here, we take a formal admixture approach and reveal a remarkably high level of North African and Sephardic Jewish ancestry in a large sample of Y chromosomes from the Iberian Peninsula and Balearic Islands. We use the power of combined binary marker and short tandem repeat (STR) haplotyping to illuminate the relative time depths of these contributions, and we show that the geographical patterns of ancestry fail to fit simple expectations based on historical accounts, suggesting the influence of religious conversion of both Muslims and Jews and the subsequent dispersal and drift of their Y-chromosomal lineages.","tracks":[{"project":"2_test","denotations":[{"id":"19061982-6418056-2048664","span":{"begin":103,"end":105},"obj":"6418056"},{"id":"19061982-2042936-2048664","span":{"begin":103,"end":105},"obj":"2042936"},{"id":"19061982-8147436-2048664","span":{"begin":103,"end":105},"obj":"8147436"},{"id":"19061982-11533990-2048664","span":{"begin":103,"end":105},"obj":"11533990"},{"id":"19061982-11129330-2048665","span":{"begin":144,"end":146},"obj":"11129330"},{"id":"19061982-8865993-2048666","span":{"begin":178,"end":180},"obj":"8865993"},{"id":"19061982-16201138-2048666","span":{"begin":178,"end":180},"obj":"16201138"},{"id":"19061982-11254456-2048667","span":{"begin":213,"end":215},"obj":"11254456"},{"id":"19061982-11543889-2048667","span":{"begin":213,"end":215},"obj":"11543889"},{"id":"19061982-12949835-2048667","span":{"begin":213,"end":215},"obj":"12949835"},{"id":"19061982-15042509-2048667","span":{"begin":213,"end":215},"obj":"15042509"},{"id":"19061982-15280900-2048667","span":{"begin":213,"end":215},"obj":"15280900"},{"id":"19061982-17351267-2048667","span":{"begin":213,"end":215},"obj":"17351267"},{"id":"19061982-11533990-2048668","span":{"begin":431,"end":433},"obj":"11533990"},{"id":"19061982-11129330-2048668","span":{"begin":431,"end":433},"obj":"11129330"},{"id":"19061982-8865993-2048668","span":{"begin":431,"end":433},"obj":"8865993"},{"id":"19061982-11254456-2048668","span":{"begin":431,"end":433},"obj":"11254456"},{"id":"19061982-12949835-2048668","span":{"begin":431,"end":433},"obj":"12949835"},{"id":"19061982-12897772-2048669","span":{"begin":551,"end":553},"obj":"12897772"},{"id":"19061982-11254456-2048670","span":{"begin":577,"end":579},"obj":"11254456"},{"id":"19061982-12949835-2048670","span":{"begin":577,"end":579},"obj":"12949835"},{"id":"19061982-15280900-2048670","span":{"begin":577,"end":579},"obj":"15280900"},{"id":"19061982-15996172-2048670","span":{"begin":577,"end":579},"obj":"15996172"},{"id":"19061982-16626329-2048670","span":{"begin":577,"end":579},"obj":"16626329"},{"id":"19061982-15280900-2048671","span":{"begin":717,"end":719},"obj":"15280900"},{"id":"19061982-15996172-2048672","span":{"begin":1017,"end":1019},"obj":"15996172"}],"attributes":[{"subj":"19061982-6418056-2048664","pred":"source","obj":"2_test"},{"subj":"19061982-2042936-2048664","pred":"source","obj":"2_test"},{"subj":"19061982-8147436-2048664","pred":"source","obj":"2_test"},{"subj":"19061982-11533990-2048664","pred":"source","obj":"2_test"},{"subj":"19061982-11129330-2048665","pred":"source","obj":"2_test"},{"subj":"19061982-8865993-2048666","pred":"source","obj":"2_test"},{"subj":"19061982-16201138-2048666","pred":"source","obj":"2_test"},{"subj":"19061982-11254456-2048667","pred":"source","obj":"2_test"},{"subj":"19061982-11543889-2048667","pred":"source","obj":"2_test"},{"subj":"19061982-12949835-2048667","pred":"source","obj":"2_test"},{"subj":"19061982-15042509-2048667","pred":"source","obj":"2_test"},{"subj":"19061982-15280900-2048667","pred":"source","obj":"2_test"},{"subj":"19061982-17351267-2048667","pred":"source","obj":"2_test"},{"subj":"19061982-11533990-2048668","pred":"source","obj":"2_test"},{"subj":"19061982-11129330-2048668","pred":"source","obj":"2_test"},{"subj":"19061982-8865993-2048668","pred":"source","obj":"2_test"},{"subj":"19061982-11254456-2048668","pred":"source","obj":"2_test"},{"subj":"19061982-12949835-2048668","pred":"source","obj":"2_test"},{"subj":"19061982-12897772-2048669","pred":"source","obj":"2_test"},{"subj":"19061982-11254456-2048670","pred":"source","obj":"2_test"},{"subj":"19061982-12949835-2048670","pred":"source","obj":"2_test"},{"subj":"19061982-15280900-2048670","pred":"source","obj":"2_test"},{"subj":"19061982-15996172-2048670","pred":"source","obj":"2_test"},{"subj":"19061982-16626329-2048670","pred":"source","obj":"2_test"},{"subj":"19061982-15280900-2048671","pred":"source","obj":"2_test"},{"subj":"19061982-15996172-2048672","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#939cec","default":true}]}]}}