PMC:2668061 / 21951-23780 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2668061","sourcedb":"PMC","sourceid":"2668061","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2668061","text":"To examine admixture in more detail, we can compare Y-STR haplotypes within prominent lineages shared between the Iberian samples and the North African and Sephardic Jewish samples. A reduced-median network representing the eight-locus haplotypes within hgE3b2, the predominant haplogroup in North Africa, is shown in Figure 5a. The network is star-like, with a major core haplotype shared by 48 North Africans and 27 Iberians, plus the sole example of a Sephardic Jewish haplotype. In total, twelve of the 51 haplotypes are shared between North Africans and Iberians, but Iberians show a lower diversity (average squared difference [ASD] = 2.85) than North Africans (ASD = 9.13). This is consistent with a history of migration of North Africans to Iberia and introgression of hgE3b2 haplotypes, representing a subset of the North African diversity, into the indigenous population. A reciprocal example is provided by hgG (Figure 5B), frequent in the Sephardic Jewish sample. In this case, only two North African chromosomes belong to this haplogroup, but 7/48 haplotypes are shared between Sephardic Jewish and Iberian chromosomes, and the respective ASD values are similar, at 14.00 and 15.10. The high degree of haplotype sharing indicates introgression of Sephardic Jews into the indigenous Iberian population, but the similarity in haplotype diversity suggests that this was relatively ancient. Supporting a contribution of Sephardic Jewish patrilines to the Iberian population, shared STR haplotypes between the two within haplogroups E3b1, J∗, J2, and K∗ (data not shown, Table S1) were also observed. The mean proportion of identical haplotypes shared between the Sephardic Jewish sample and the Iberian samples is 3.6%, whereas the proportion for those shared between the Moroccan sample and the Iberian samples is 2.8%.","tracks":[]}