PMC:2664230 / 21746-22290
Annnotations
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8346 | 158-161 | Protein | denotes | p65 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
18568240-12230568-22101135 | 187-189 | 12230568 | denotes | 33 |
18568240-8702838-22101136 | 403-404 | 8702838 | denotes | 9 |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9148 | 0-4 | DT | denotes | This |
T9149 | 5-10 | NN | denotes | group |
T9150 | 11-15 | RB | denotes | also |
T9151 | 16-28 | VBD | denotes | demonstrated |
T9152 | 29-33 | IN | denotes | that |
T9153 | 34-43 | NN | denotes | forskolin |
T9154 | 44-47 | VBD | denotes | did |
T9155 | 48-51 | RB | denotes | not |
T9156 | 52-59 | VB | denotes | inhibit |
T9157 | 60-63 | DT | denotes | the |
T9158 | 64-75 | JJ | denotes | DNA-binding |
T9159 | 76-84 | NN | denotes | activity |
T9160 | 85-87 | IN | denotes | of |
T9161 | 88-93 | NNP | denotes | NF-κB |
T9162 | 94-97 | CC | denotes | and |
T9163 | 98-102 | IN | denotes | that |
T9164 | 103-107 | NNP | denotes | CREB |
T9165 | 108-111 | VBD | denotes | was |
T9166 | 112-115 | RB | denotes | not |
T9167 | 116-124 | VBN | denotes | involved |
T9168 | 125-127 | IN | denotes | in |
T9169 | 128-145 | JJ | denotes | forskolin-induced |
T9170 | 146-154 | NN | denotes | decrease |
T9171 | 155-157 | IN | denotes | in |
T9172 | 158-161 | CD | denotes | p65 |
T9173 | 162-177 | JJ | denotes | transcriptional |
T9174 | 178-186 | NN | denotes | activity |
T9175 | 186-189 | CD | denotes | .33 |
T9176 | 190-197 | JJ | denotes | Similar |
T9177 | 198-205 | NNS | denotes | results |
T9178 | 206-210 | VBD | denotes | were |
T9179 | 211-219 | VBN | denotes | reported |
T9180 | 220-222 | IN | denotes | by |
T9181 | 223-231 | NNP | denotes | Ollivier |
T9182 | 232-234 | FW | denotes | et |
T9183 | 235-238 | FW | denotes | al. |
T9184 | 239-244 | VBG | denotes | using |
T9185 | 245-250 | CD | denotes | THP-1 |
T9186 | 251-256 | NNS | denotes | cells |
T9187 | 257-260 | CC | denotes | and |
T9188 | 261-272 | JJ | denotes | endothelial |
T9189 | 273-278 | NNS | denotes | cells |
T9190 | 279-286 | VBN | denotes | treated |
T9191 | 287-291 | IN | denotes | with |
T9192 | 292-301 | NN | denotes | forskolin |
T9193 | 302-304 | CC | denotes | or |
T9194 | 305-314 | NN | denotes | dibutyryl |
T9195 | 315-319 | NNP | denotes | cAMP |
T9196 | 319-320 | , | denotes | , |
T9197 | 321-324 | CD | denotes | two |
T9198 | 325-331 | NNS | denotes | agents |
T9199 | 332-337 | VBN | denotes | known |
T9200 | 338-340 | TO | denotes | to |
T9201 | 341-349 | VB | denotes | function |
T9202 | 350-357 | IN | denotes | through |
T9203 | 358-362 | NNP | denotes | cAMP |
T9204 | 363-372 | NN | denotes | elevation |
T9205 | 373-376 | CC | denotes | and |
T9206 | 377-387 | JJ | denotes | subsequent |
T9207 | 388-391 | NNP | denotes | PKA |
T9208 | 392-402 | NN | denotes | activation |
T9209 | 402-404 | CD | denotes | .9 |
T9210 | 405-408 | DT | denotes | The |
T9211 | 409-420 | NNS | denotes | differences |
T9212 | 421-428 | IN | denotes | between |
T9213 | 429-432 | PRP$ | denotes | our |
T9214 | 433-440 | NNS | denotes | results |
T9215 | 441-444 | CC | denotes | and |
T9216 | 445-450 | DT | denotes | those |
T9217 | 451-460 | VBN | denotes | mentioned |
T9218 | 461-466 | IN | denotes | above |
T9219 | 467-470 | MD | denotes | may |
T9220 | 471-473 | VB | denotes | be |
T9221 | 474-483 | VBN | denotes | explained |
T9222 | 484-486 | IN | denotes | by |
T9223 | 487-490 | DT | denotes | the |
T9224 | 491-494 | NN | denotes | use |
T9225 | 495-497 | IN | denotes | of |
T9226 | 498-507 | JJ | denotes | different |
T9227 | 508-512 | NN | denotes | cell |
T9228 | 513-518 | NNS | denotes | types |
T9229 | 519-522 | CC | denotes | and |
T9230 | 523-532 | JJ | denotes | exogenous |
T9231 | 533-543 | NNS | denotes | stimulants |
T9232 | 543-544 | . | denotes | . |
R7569 | T9148 | T9149 | det | This,group |
R7570 | T9149 | T9151 | nsubj | group,demonstrated |
R7571 | T9150 | T9151 | advmod | also,demonstrated |
R7572 | T9151 | T9151 | ROOT | demonstrated,demonstrated |
R7573 | T9152 | T9156 | mark | that,inhibit |
R7574 | T9153 | T9156 | nsubj | forskolin,inhibit |
R7575 | T9154 | T9156 | aux | did,inhibit |
R7576 | T9155 | T9156 | neg | not,inhibit |
R7577 | T9156 | T9151 | ccomp | inhibit,demonstrated |
R7578 | T9157 | T9159 | det | the,activity |
R7579 | T9158 | T9159 | amod | DNA-binding,activity |
R7580 | T9159 | T9156 | dobj | activity,inhibit |
R7581 | T9160 | T9159 | prep | of,activity |
R7582 | T9161 | T9160 | pobj | NF-κB,of |
R7583 | T9162 | T9156 | cc | and,inhibit |
R7584 | T9163 | T9167 | mark | that,involved |
R7585 | T9164 | T9167 | nsubjpass | CREB,involved |
R7586 | T9165 | T9167 | auxpass | was,involved |
R7587 | T9166 | T9167 | neg | not,involved |
R7588 | T9167 | T9156 | conj | involved,inhibit |
R7589 | T9168 | T9167 | prep | in,involved |
R7590 | T9169 | T9170 | amod | forskolin-induced,decrease |
R7591 | T9170 | T9168 | pobj | decrease,in |
R7592 | T9171 | T9170 | prep | in,decrease |
R7593 | T9172 | T9174 | nummod | p65,activity |
R7594 | T9173 | T9174 | amod | transcriptional,activity |
R7595 | T9174 | T9171 | pobj | activity,in |
R7596 | T9175 | T9177 | nummod | .33,results |
R7597 | T9176 | T9177 | amod | Similar,results |
R7598 | T9177 | T9179 | nsubjpass | results,reported |
R7599 | T9178 | T9179 | auxpass | were,reported |
R7600 | T9179 | T9151 | conj | reported,demonstrated |
R7601 | T9180 | T9179 | agent | by,reported |
R7602 | T9181 | T9180 | pobj | Ollivier,by |
R7603 | T9182 | T9183 | nmod | et,al. |
R7604 | T9183 | T9184 | npadvmod | al.,using |
R7605 | T9184 | T9179 | advcl | using,reported |
R7606 | T9185 | T9186 | nummod | THP-1,cells |
R7607 | T9186 | T9184 | dobj | cells,using |
R7608 | T9187 | T9186 | cc | and,cells |
R7609 | T9188 | T9189 | amod | endothelial,cells |
R7610 | T9189 | T9186 | conj | cells,cells |
R7611 | T9190 | T9186 | acl | treated,cells |
R7612 | T9191 | T9190 | prep | with,treated |
R7613 | T9192 | T9191 | pobj | forskolin,with |
R7614 | T9193 | T9192 | cc | or,forskolin |
R7615 | T9194 | T9195 | compound | dibutyryl,cAMP |
R7616 | T9195 | T9192 | conj | cAMP,forskolin |
R7617 | T9196 | T9195 | punct | ",",cAMP |
R7618 | T9197 | T9198 | nummod | two,agents |
R7619 | T9198 | T9195 | appos | agents,cAMP |
R7620 | T9199 | T9198 | acl | known,agents |
R7621 | T9200 | T9201 | aux | to,function |
R7622 | T9201 | T9199 | xcomp | function,known |
R7623 | T9202 | T9201 | prep | through,function |
R7624 | T9203 | T9204 | compound | cAMP,elevation |
R7625 | T9204 | T9202 | pobj | elevation,through |
R7626 | T9205 | T9204 | cc | and,elevation |
R7627 | T9206 | T9208 | amod | subsequent,activation |
R7628 | T9207 | T9208 | compound | PKA,activation |
R7629 | T9208 | T9204 | conj | activation,elevation |
R7630 | T9209 | T9208 | nummod | .9,activation |
R7631 | T9210 | T9211 | det | The,differences |
R7632 | T9211 | T9201 | dobj | differences,function |
R7633 | T9212 | T9211 | prep | between,differences |
R7634 | T9213 | T9214 | poss | our,results |
R7635 | T9214 | T9212 | pobj | results,between |
R7636 | T9215 | T9214 | cc | and,results |
R7637 | T9216 | T9214 | conj | those,results |
R7638 | T9217 | T9216 | acl | mentioned,those |
R7639 | T9218 | T9217 | advmod | above,mentioned |
R7640 | T9219 | T9221 | aux | may,explained |
R7641 | T9220 | T9221 | auxpass | be,explained |
R7642 | T9221 | T9151 | conj | explained,demonstrated |
R7643 | T9222 | T9221 | agent | by,explained |
R7644 | T9223 | T9224 | det | the,use |
R7645 | T9224 | T9222 | pobj | use,by |
R7646 | T9225 | T9224 | prep | of,use |
R7647 | T9226 | T9228 | amod | different,types |
R7648 | T9227 | T9228 | compound | cell,types |
R7649 | T9228 | T9225 | pobj | types,of |
R7650 | T9229 | T9228 | cc | and,types |
R7651 | T9230 | T9231 | amod | exogenous,stimulants |
R7652 | T9231 | T9228 | conj | stimulants,types |
R7653 | T9232 | T9151 | punct | .,demonstrated |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9859 | 162-177 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcriptional |
T9898 | 388-391 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | PKA |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T10039 | 388-391 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | PKA |
T10050 | 64-75 | http://purl.obolibrary.org/obo/GO_0003677 | denotes | DNA-binding |
T10054 | 68-75 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T10066 | 251-256 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T10067 | 273-278 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T10075 | 388-391 | http://purl.obolibrary.org/obo/GO_0005952 | denotes | PKA |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8392 | 0-544 | Sentence | denotes | This group also demonstrated that forskolin did not inhibit the DNA-binding activity of NF-κB and that CREB was not involved in forskolin-induced decrease in p65 transcriptional activity.33 Similar results were reported by Ollivier et al. using THP-1 cells and endothelial cells treated with forskolin or dibutyryl cAMP, two agents known to function through cAMP elevation and subsequent PKA activation.9 The differences between our results and those mentioned above may be explained by the use of different cell types and exogenous stimulants. |
T148 | 0-544 | Sentence | denotes | This group also demonstrated that forskolin did not inhibit the DNA-binding activity of NF-κB and that CREB was not involved in forskolin-induced decrease in p65 transcriptional activity.33 Similar results were reported by Ollivier et al. using THP-1 cells and endothelial cells treated with forskolin or dibutyryl cAMP, two agents known to function through cAMP elevation and subsequent PKA activation.9 The differences between our results and those mentioned above may be explained by the use of different cell types and exogenous stimulants. |
events-check-again
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T10629 | 158-161 | Protein | denotes | p65 |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T10218 | 88-93 | Protein | denotes | NF-κB |
T10219 | 103-107 | Protein | denotes | CREB |
T10220 | 158-161 | Protein | denotes | p65 |
T10221 | 388-391 | Protein | denotes | PKA |
T10222 | 52-59 | Negative_regulation | denotes | inhibit |
T10223 | 146-154 | Negative_regulation | denotes | decrease |
R8283 | T10218 | T10222 | themeOf | NF-κB,inhibit |
R8284 | T10220 | T10223 | themeOf | p65,decrease |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9742 | 103-107 | Q8TEY5 | denotes | CREB |
T9743 | 103-107 | Q02930 | denotes | CREB |
T9744 | 103-107 | P18848 | denotes | CREB |
T9745 | 103-107 | P16220 | denotes | CREB |
T9746 | 103-107 | P15336 | denotes | CREB |
T9747 | 103-107 | O43889 | denotes | CREB |
T9748 | 158-161 | P21579 | denotes | p65 |
T9749 | 158-161 | Q04206 | denotes | p65 |
test2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8243 | 138-145 | Positive_regulation | denotes | induced |
T8244 | 146-154 | Negative_regulation | denotes | decrease |
T8245 | 158-161 | Protein | denotes | p65 |
T8246 | 162-177 | Transcription | denotes | transcriptional |
R6753 | T8244 | T8243 | themeOf | decrease,induced |
R6754 | T8245 | T8246 | themeOf | p65,transcriptional |
R6755 | T8246 | T8244 | themeOf | transcriptional,decrease |