PMC:2626671 / 3099-3483
Annnotations
pmc-enju-pas
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regulation of the Il4 and Ifng cytokine genes (15, 16). In contrast, all three Runx proteins are expressed in mature CD8+ T cells (10, 12), and Runx3-deficient CD8+ T cells show reduced cytolytic activity (12, 13). We therefore tested whether Runx3 influenced cytolytic T cell differentiation.\nIn this report, we show that Runx3 and T-box factors synergistically regulate CTL differe"}
bionlp-st-ge-2016-spacy-parsed
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regulation of the Il4 and Ifng cytokine genes (15, 16). In contrast, all three Runx proteins are expressed in mature CD8+ T cells (10, 12), and Runx3-deficient CD8+ T cells show reduced cytolytic activity (12, 13). We therefore tested whether Runx3 influenced cytolytic T cell differentiation.\nIn this report, we show that Runx3 and T-box factors synergistically regulate CTL differe"}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T826","span":{"begin":1,"end":11},"obj":"http://purl.obolibrary.org/obo/GO_0065007"}],"text":" regulation of the Il4 and Ifng cytokine genes (15, 16). In contrast, all three Runx proteins are expressed in mature CD8+ T cells (10, 12), and Runx3-deficient CD8+ T cells show reduced cytolytic activity (12, 13). We therefore tested whether Runx3 influenced cytolytic T cell differentiation.\nIn this report, we show that Runx3 and T-box factors synergistically regulate CTL differe"}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T2085","span":{"begin":125,"end":130},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2086","span":{"begin":168,"end":173},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":" regulation of the Il4 and Ifng cytokine genes (15, 16). In contrast, all three Runx proteins are expressed in mature CD8+ T cells (10, 12), and Runx3-deficient CD8+ T cells show reduced cytolytic activity (12, 13). We therefore tested whether Runx3 influenced cytolytic T cell differentiation.\nIn this report, we show that Runx3 and T-box factors synergistically regulate CTL differe"}
sentences
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events-check-again
{"project":"events-check-again","denotations":[{"id":"T2597","span":{"begin":1,"end":11},"obj":"Regulation"},{"id":"T2598","span":{"begin":1,"end":11},"obj":"Regulation"},{"id":"T2599","span":{"begin":19,"end":22},"obj":"Protein"},{"id":"T2600","span":{"begin":27,"end":31},"obj":"Protein"},{"id":"T2601","span":{"begin":118,"end":121},"obj":"Protein"},{"id":"T2602","span":{"begin":145,"end":150},"obj":"Protein"},{"id":"T2603","span":{"begin":151,"end":160},"obj":"Negative_regulation"},{"id":"T2604","span":{"begin":161,"end":164},"obj":"Protein"},{"id":"T2605","span":{"begin":244,"end":249},"obj":"Protein"},{"id":"T2606","span":{"begin":324,"end":329},"obj":"Protein"}],"relations":[{"id":"R2029","pred":"themeOf","subj":"T2599","obj":"T2597"},{"id":"R2030","pred":"themeOf","subj":"T2600","obj":"T2598"},{"id":"R2031","pred":"themeOf","subj":"T2602","obj":"T2603"}],"text":" regulation of the Il4 and Ifng cytokine genes (15, 16). In contrast, all three Runx proteins are expressed in mature CD8+ T cells (10, 12), and Runx3-deficient CD8+ T cells show reduced cytolytic activity (12, 13). We therefore tested whether Runx3 influenced cytolytic T cell differentiation.\nIn this report, we show that Runx3 and T-box factors synergistically regulate CTL differe"}
bionlp-st-ge-2016-reference
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bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T2031","span":{"begin":80,"end":84},"obj":"Q13761"},{"id":"T2032","span":{"begin":80,"end":84},"obj":"Q01196"},{"id":"T2033","span":{"begin":80,"end":84},"obj":"Q13950"},{"id":"T2034","span":{"begin":118,"end":121},"obj":"P01732"},{"id":"T2035","span":{"begin":118,"end":121},"obj":"P10966"},{"id":"T2036","span":{"begin":145,"end":150},"obj":"Q13761"},{"id":"T2037","span":{"begin":161,"end":164},"obj":"P10966"},{"id":"T2038","span":{"begin":161,"end":164},"obj":"P01732"},{"id":"T2039","span":{"begin":244,"end":249},"obj":"Q13761"},{"id":"T2040","span":{"begin":324,"end":329},"obj":"Q13761"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":" regulation of the Il4 and Ifng cytokine genes (15, 16). In contrast, all three Runx proteins are expressed in mature CD8+ T cells (10, 12), and Runx3-deficient CD8+ T cells show reduced cytolytic activity (12, 13). We therefore tested whether Runx3 influenced cytolytic T cell differentiation.\nIn this report, we show that Runx3 and T-box factors synergistically regulate CTL differe"}
test2
{"project":"test2","denotations":[{"id":"T778","span":{"begin":1,"end":11},"obj":"Regulation"},{"id":"T779","span":{"begin":15,"end":40},"obj":"Protein"},{"id":"T780","span":{"begin":98,"end":107},"obj":"Gene_expression"},{"id":"T781","span":{"begin":118,"end":121},"obj":"Protein"},{"id":"T782","span":{"begin":145,"end":150},"obj":"Protein"},{"id":"T783","span":{"begin":151,"end":160},"obj":"Negative_regulation"},{"id":"T784","span":{"begin":161,"end":164},"obj":"Protein"},{"id":"T785","span":{"begin":244,"end":249},"obj":"Protein"},{"id":"T786","span":{"begin":324,"end":329},"obj":"Protein"}],"relations":[{"id":"R610","pred":"themeOf","subj":"T779","obj":"T778"},{"id":"R611","pred":"themeOf","subj":"T782","obj":"T783"}],"text":" regulation of the Il4 and Ifng cytokine genes (15, 16). In contrast, all three Runx proteins are expressed in mature CD8+ T cells (10, 12), and Runx3-deficient CD8+ T cells show reduced cytolytic activity (12, 13). We therefore tested whether Runx3 influenced cytolytic T cell differentiation.\nIn this report, we show that Runx3 and T-box factors synergistically regulate CTL differe"}