PMC:2626671 / 21579-25275 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
19139168-12464175-59674062	344-346	12464175	denotes	12
19139168-16273099-59674063	1692-1693	16273099	denotes	8
19139168-16273099-59674064	1772-1773	16273099	denotes	8
19139168-15084276-59674065	1775-1777	15084276	denotes	26
19139168-14605368-59674066	1858-1859	14605368	denotes	7
19139168-10716450-59674067	2612-2614	10716450	denotes	27
19139168-18635804-59674068	2704-2705	18635804	denotes	9
19139168-17195845-59674069	3222-3224	17195845	denotes	15
19139168-17195845-59674070	3360-3362	17195845	denotes	15

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T12595	349-351	Anaphor	denotes	It
T12596	286-291	Antecedent	denotes	Runx3
T12597	512-534	Anaphor	denotes	the latter three genes
T12598	419-429	Antecedent	denotes	granzyme B
T12599	431-439	Antecedent	denotes	perforin
T12600	445-450	Antecedent	denotes	IFN-γ
T12601	1049-1052	Anaphor	denotes	its
T12602	963-968	Antecedent	denotes	Runx3
T12603	1545-1550	Anaphor	denotes	which
T12604	1538-1543	Antecedent	denotes	Eomes
T12605	2041-2058	Anaphor	denotes	two other markers
T12606	2076-2080	Antecedent	denotes	Prf1
T12607	2085-2089	Antecedent	denotes	Gzmb
R9989	T12595	T12596	boundBy	It,Runx3
R9990	T12597	T12598	boundBy	the latter three genes,granzyme B
R9991	T12597	T12599	boundBy	the latter three genes,perforin
R9992	T12597	T12600	boundBy	the latter three genes,IFN-γ
R9993	T12601	T12602	boundBy	its,Runx3
R9994	T12603	T12604	boundBy	which,Eomes
R9995	T12605	T12606	boundBy	two other markers,Prf1
R9996	T12605	T12607	boundBy	two other markers,Gzmb

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T11912	0-5	JJ	denotes	Runx3
T11913	6-9	CC	denotes	and
T11914	10-15	JJ	denotes	T-box
T11915	16-23	NNS	denotes	factors
T11916	24-31	VBP	denotes	control
T11917	32-33	DT	denotes	a
T11918	34-41	JJ	denotes	complex
T11919	42-49	NN	denotes	program
T11920	50-52	IN	denotes	of
T11921	53-68	JJ	denotes	transcriptional
T11922	69-79	NN	denotes	regulation
T11923	80-86	IN	denotes	during
T11924	87-90	NNP	denotes	CTL
T11925	91-106	NN	denotes	differentiation
T11926	107-119	RB	denotes	Collectively
T11927	119-120	,	denotes	,
T11928	121-126	DT	denotes	these
T11929	127-131	NNS	denotes	data
T11930	132-139	VBP	denotes	provide
T11931	140-148	NN	denotes	evidence
T11932	149-153	IN	denotes	that
T11933	154-159	NNP	denotes	Runx3
T11934	159-160	,	denotes	,
T11935	161-169	RB	denotes	together
T11936	170-174	IN	denotes	with
T11937	175-180	JJ	denotes	T-box
T11938	181-188	NNS	denotes	factors
T11939	188-189	,	denotes	,
T11940	190-202	VBZ	denotes	orchestrates
T11941	203-204	DT	denotes	a
T11942	205-212	JJ	denotes	complex
T11943	213-220	NN	denotes	program
T11944	221-223	IN	denotes	of
T11945	224-239	JJ	denotes	transcriptional
T11946	240-250	NN	denotes	regulation
T11947	251-253	IN	denotes	in
T11948	254-269	VBG	denotes	differentiating
T11949	270-273	NNP	denotes	CTL
T11950	274-275	-LRB-	denotes	(
T11951	275-279	NNP	denotes	Fig.
T11952	280-281	CD	denotes	4
T11953	282-283	NNP	denotes	C
T11954	283-284	-RRB-	denotes	)
T11955	284-285	.	denotes	.
T11956	286-291	NN	denotes	Runx3
T11957	292-294	VBZ	denotes	is
T11958	295-302	JJ	denotes	present
T11959	303-305	IN	denotes	in
T11960	306-311	JJ	denotes	naive
T11961	312-315	NNP	denotes	CD8
T11962	315-316	CD	denotes	+
T11963	317-318	NNP	denotes	T
T11964	319-324	NNS	denotes	cells
T11965	325-331	IN	denotes	before
T11966	332-342	NN	denotes	activation
T11967	343-344	-LRB-	denotes	(
T11968	344-346	CD	denotes	12
T11969	346-347	-RRB-	denotes	)
T11970	347-348	.	denotes	.
T11971	349-351	PRP	denotes	It
T11972	352-361	VBZ	denotes	represses
T11973	362-367	NNP	denotes	Runx1
T11974	368-371	CC	denotes	and
T11975	372-375	VBZ	denotes	has
T11976	376-377	DT	denotes	a
T11977	378-386	JJ	denotes	positive
T11978	387-391	NN	denotes	role
T11979	392-394	IN	denotes	in
T11980	395-398	DT	denotes	the
T11981	399-408	NN	denotes	induction
T11982	409-411	IN	denotes	of
T11983	412-417	NNP	denotes	Eomes
T11984	417-418	,	denotes	,
T11985	419-427	NN	denotes	granzyme
T11986	428-429	NNP	denotes	B
T11987	429-430	,	denotes	,
T11988	431-439	NN	denotes	perforin
T11989	439-440	,	denotes	,
T11990	441-444	CC	denotes	and
T11991	445-450	NNP	denotes	IFN-γ
T11992	450-451	.	denotes	.
T11993	452-457	JJ	denotes	Runx3
T11994	458-463	NNS	denotes	binds
T11995	464-466	TO	denotes	to
T11996	467-476	NNS	denotes	promoters
T11997	477-480	CC	denotes	and
T11998	481-489	JJ	denotes	putative
T11999	490-500	JJ	denotes	regulatory
T12000	501-508	NNS	denotes	regions
T12001	509-511	IN	denotes	of
T12002	512-515	DT	denotes	the
T12003	516-522	JJ	denotes	latter
T12004	523-528	CD	denotes	three
T12005	529-534	NNS	denotes	genes
T12006	534-535	,	denotes	,
T12007	536-546	VBG	denotes	suggesting
T12008	547-548	DT	denotes	a
T12009	549-555	JJ	denotes	direct
T12010	556-562	NN	denotes	effect
T12011	563-565	IN	denotes	on
T12012	566-570	NN	denotes	gene
T12013	571-581	NN	denotes	expression
T12014	581-582	.	denotes	.
T12015	583-593	JJ	denotes	Additional
T12016	594-605	NNS	denotes	experiments
T12017	606-609	VBP	denotes	are
T12018	610-616	VBN	denotes	needed
T12019	617-619	TO	denotes	to
T12020	620-629	VB	denotes	determine
T12021	630-637	IN	denotes	whether
T12022	638-643	NNP	denotes	Eomes
T12023	644-647	CC	denotes	and
T12024	648-653	NNP	denotes	Runx1
T12025	654-657	VBP	denotes	are
T12026	658-662	RB	denotes	also
T12027	663-669	JJ	denotes	direct
T12028	670-676	NN	denotes	target
T12029	677-682	NNS	denotes	genes
T12030	683-685	IN	denotes	of
T12031	686-691	NNP	denotes	Runx3
T12032	691-692	.	denotes	.
T12033	693-705	RB	denotes	Surprisingly
T12034	705-706	,	denotes	,
T12035	707-712	JJ	denotes	Runx3
T12036	713-724	VBD	denotes	contributed
T12037	725-727	TO	denotes	to
T12038	728-731	DT	denotes	the
T12039	732-739	JJ	denotes	optimal
T12040	740-750	NN	denotes	expression
T12041	751-753	IN	denotes	of
T12042	754-757	NNP	denotes	TNF
T12043	757-758	,	denotes	,
T12044	759-763	NNP	denotes	IL-2
T12045	763-764	,	denotes	,
T12046	765-768	CC	denotes	and
T12047	769-774	NNP	denotes	IFN-γ
T12048	775-777	IN	denotes	at
T12049	778-781	NN	denotes	day
T12050	782-783	CD	denotes	4
T12051	784-785	-LRB-	denotes	(
T12052	785-788	NN	denotes	Fig
T12053	788-789	.	denotes	.
T12054	790-792	CD	denotes	S2
T12055	792-793	-RRB-	denotes	)
T12056	793-794	.	denotes	.
T12057	795-798	IN	denotes	For
T12058	799-802	NNP	denotes	TNF
T12059	803-806	CC	denotes	and
T12060	807-811	NNP	denotes	IL-2
T12061	811-812	,	denotes	,
T12062	813-816	DT	denotes	the
T12063	817-828	NN	denotes	requirement
T12064	829-832	IN	denotes	for
T12065	833-838	JJ	denotes	Runx3
T12066	839-847	NNS	denotes	subsides
T12067	848-850	IN	denotes	by
T12068	851-854	NN	denotes	day
T12069	855-856	CD	denotes	6
T12070	857-858	-LRB-	denotes	(
T12071	858-862	NN	denotes	Fig.
T12072	863-864	CD	denotes	3
T12073	865-866	NNP	denotes	C
T12074	866-867	-RRB-	denotes	)
T12075	867-868	,	denotes	,
T12076	869-877	RB	denotes	possibly
T12077	878-885	IN	denotes	because
T12078	886-888	IN	denotes	of
T12079	889-901	NN	denotes	compensation
T12080	902-904	IN	denotes	by
T12081	905-910	NNP	denotes	Runx1
T12082	910-911	,	denotes	,
T12083	912-917	WDT	denotes	which
T12084	918-920	VBZ	denotes	is
T12085	921-932	VBN	denotes	derepressed
T12086	933-935	IN	denotes	in
T12087	936-941	NNP	denotes	Runx3
T12088	941-942	NNP	denotes	−
T12089	942-943	VBD	denotes	/
T12090	943-944	CD	denotes	−
T12091	945-950	NNS	denotes	cells
T12092	951-952	-LRB-	denotes	(
T12093	952-956	NN	denotes	Fig.
T12094	957-958	CD	denotes	4
T12095	959-960	NNP	denotes	A
T12096	960-961	-RRB-	denotes	)
T12097	961-962	.	denotes	.
T12098	963-968	JJ	denotes	Runx3
T12099	969-978	VBZ	denotes	continues
T12100	979-981	TO	denotes	to
T12101	982-984	VB	denotes	be
T12102	985-993	VBN	denotes	required
T12103	994-997	IN	denotes	for
T12104	998-1003	JJ	denotes	IFN-γ
T12105	1004-1014	NN	denotes	expression
T12106	1015-1019	RB	denotes	even
T12107	1020-1022	IN	denotes	at
T12108	1023-1026	NN	denotes	day
T12109	1027-1028	CD	denotes	6
T12110	1028-1029	,	denotes	,
T12111	1030-1037	RB	denotes	perhaps
T12112	1038-1045	IN	denotes	because
T12113	1046-1048	IN	denotes	of
T12114	1049-1052	PRP$	denotes	its
T12115	1053-1057	NN	denotes	role
T12116	1058-1060	IN	denotes	in
T12117	1061-1064	DT	denotes	the
T12118	1065-1074	NN	denotes	induction
T12119	1075-1077	IN	denotes	of
T12120	1078-1083	NNP	denotes	Eomes
T12121	1084-1094	NN	denotes	expression
T12122	1095-1096	-LRB-	denotes	(
T12123	1096-1100	JJ	denotes	Fig.
T12124	1101-1102	CD	denotes	4
T12125	1103-1104	NN	denotes	A
T12126	1104-1105	-RRB-	denotes	)
T12127	1105-1106	.	denotes	.
T12128	1107-1109	DT	denotes	An
T12129	1110-1120	JJ	denotes	unexpected
T12130	1121-1128	NN	denotes	finding
T12131	1129-1132	VBD	denotes	was
T12132	1133-1137	IN	denotes	that
T12133	1138-1141	DT	denotes	the
T12134	1142-1145	CD	denotes	two
T12135	1146-1151	JJ	denotes	T-box
T12136	1152-1165	NN	denotes	transcription
T12137	1166-1173	NNS	denotes	factors
T12138	1173-1174	,	denotes	,
T12139	1175-1180	NNP	denotes	T-bet
T12140	1181-1184	CC	denotes	and
T12141	1185-1190	NNP	denotes	Eomes
T12142	1190-1191	,	denotes	,
T12143	1192-1195	VBP	denotes	are
T12144	1196-1208	JJ	denotes	up-regulated
T12145	1209-1213	IN	denotes	with
T12146	1214-1218	RB	denotes	very
T12147	1219-1228	JJ	denotes	different
T12148	1229-1237	NNS	denotes	kinetics
T12149	1238-1240	IN	denotes	in
T12150	1241-1244	CD	denotes	CD8
T12151	1244-1245	CD	denotes	+
T12152	1246-1247	NNP	denotes	T
T12153	1248-1253	NNS	denotes	cells
T12154	1254-1259	IN	denotes	under
T12155	1260-1263	PRP$	denotes	our
T12156	1264-1271	NN	denotes	culture
T12157	1272-1282	NNS	denotes	conditions
T12158	1283-1286	CC	denotes	and
T12159	1287-1291	VBP	denotes	have
T12160	1292-1304	JJ	denotes	nonredundant
T12161	1305-1310	NNS	denotes	roles
T12162	1311-1313	IN	denotes	in
T12163	1314-1317	DT	denotes	the
T12164	1318-1328	JJ	denotes	subsequent
T12165	1329-1339	NN	denotes	expression
T12166	1340-1342	IN	denotes	of
T12167	1343-1346	JJ	denotes	key
T12168	1347-1355	NN	denotes	effector
T12169	1356-1364	NNS	denotes	proteins
T12170	1365-1366	-LRB-	denotes	(
T12171	1366-1370	NN	denotes	Fig.
T12172	1371-1372	CD	denotes	4
T12173	1373-1374	NNP	denotes	C
T12174	1374-1375	-RRB-	denotes	)
T12175	1375-1376	.	denotes	.
T12176	1377-1382	NN	denotes	T-bet
T12177	1383-1385	VBZ	denotes	is
T12178	1386-1392	VBN	denotes	needed
T12179	1393-1398	RB	denotes	early
T12180	1399-1401	TO	denotes	to
T12181	1402-1408	VB	denotes	confer
T12182	1409-1411	IN	denotes	on
T12183	1412-1421	VBN	denotes	activated
T12184	1422-1425	NNP	denotes	CD8
T12185	1425-1426	CD	denotes	+
T12186	1427-1428	NNP	denotes	T
T12187	1429-1434	NNS	denotes	cells
T12188	1435-1438	DT	denotes	the
T12189	1439-1449	NN	denotes	competence
T12190	1450-1452	TO	denotes	to
T12191	1453-1460	VB	denotes	produce
T12192	1461-1466	JJ	denotes	IFN-γ
T12193	1467-1471	IN	denotes	upon
T12194	1472-1485	NN	denotes	restimulation
T12195	1485-1486	,	denotes	,
T12196	1487-1490	CC	denotes	but
T12197	1491-1494	PRP$	denotes	its
T12198	1495-1503	NN	denotes	function
T12199	1504-1506	VBZ	denotes	is
T12200	1507-1511	RBR	denotes	less
T12201	1512-1521	JJ	denotes	important
T12202	1522-1524	IN	denotes	at
T12203	1525-1530	JJ	denotes	later
T12204	1531-1536	NNS	denotes	times
T12205	1536-1537	.	denotes	.
T12206	1538-1543	NNS	denotes	Eomes
T12207	1543-1544	,	denotes	,
T12208	1545-1550	WDT	denotes	which
T12209	1551-1553	VBZ	denotes	is
T12210	1554-1561	VBN	denotes	induced
T12211	1562-1566	RB	denotes	late
T12212	1567-1570	CC	denotes	and
T12213	1571-1580	NNS	denotes	functions
T12214	1581-1591	JJ	denotes	downstream
T12215	1592-1594	IN	denotes	of
T12216	1595-1600	NNP	denotes	Runx3
T12217	1600-1601	,	denotes	,
T12218	1602-1605	MD	denotes	may
T12219	1606-1616	VB	denotes	substitute
T12220	1617-1620	IN	denotes	for
T12221	1621-1626	NN	denotes	T-bet
T12222	1627-1629	IN	denotes	in
T12223	1630-1639	VBG	denotes	promoting
T12224	1640-1643	DT	denotes	the
T12225	1644-1649	JJ	denotes	acute
T12226	1650-1660	NN	denotes	expression
T12227	1661-1663	IN	denotes	of
T12228	1664-1669	NNP	denotes	IFN-γ
T12229	1670-1672	IN	denotes	in
T12230	1673-1685	JJ	denotes	restimulated
T12231	1686-1690	NNS	denotes	CTLs
T12232	1691-1692	-LRB-	denotes	(
T12233	1692-1693	CD	denotes	8
T12234	1693-1694	-RRB-	denotes	)
T12235	1694-1695	.	denotes	.
T12236	1696-1702	RB	denotes	Indeed
T12237	1702-1703	,	denotes	,
T12238	1704-1709	NNP	denotes	T-bet
T12239	1710-1713	CC	denotes	and
T12240	1714-1719	NNP	denotes	Eomes
T12241	1720-1724	DT	denotes	both
T12242	1725-1735	VBP	denotes	contribute
T12243	1736-1738	TO	denotes	to
T12244	1739-1747	VB	denotes	perforin
T12245	1748-1758	NN	denotes	expression
T12246	1759-1761	IN	denotes	in
T12247	1762-1764	NNP	denotes	NK
T12248	1765-1770	NNS	denotes	cells
T12249	1771-1772	-LRB-	denotes	(
T12250	1772-1773	CD	denotes	8
T12251	1773-1774	,	denotes	,
T12252	1775-1777	CD	denotes	26
T12253	1777-1778	-RRB-	denotes	)
T12254	1778-1779	,	denotes	,
T12255	1780-1783	CC	denotes	and
T12256	1784-1789	NNP	denotes	Eomes
T12257	1790-1797	VBZ	denotes	induces
T12258	1798-1806	NN	denotes	granzyme
T12259	1807-1808	NN	denotes	B
T12260	1809-1811	IN	denotes	as
T12261	1812-1823	RB	denotes	effectively
T12262	1824-1826	IN	denotes	as
T12263	1827-1832	NN	denotes	T-bet
T12264	1833-1835	IN	denotes	in
T12265	1836-1846	VBG	denotes	developing
T12266	1847-1850	JJ	denotes	Th2
T12267	1851-1856	NNS	denotes	cells
T12268	1857-1858	-LRB-	denotes	(
T12269	1858-1859	CD	denotes	7
T12270	1859-1860	-RRB-	denotes	)
T12271	1860-1861	:	denotes	;
T12272	1862-1866	RB	denotes	thus
T12273	1866-1867	,	denotes	,
T12274	1868-1871	DT	denotes	the
T12275	1872-1880	JJ	denotes	relative
T12276	1881-1886	NNS	denotes	roles
T12277	1887-1889	IN	denotes	of
T12278	1890-1895	DT	denotes	these
T12279	1896-1901	JJ	denotes	T-box
T12280	1902-1915	NN	denotes	transcription
T12281	1916-1923	NNS	denotes	factors
T12282	1924-1928	VBP	denotes	vary
T12283	1929-1938	VBG	denotes	depending
T12284	1939-1941	IN	denotes	on
T12285	1942-1946	NN	denotes	cell
T12286	1947-1951	NN	denotes	type
T12287	1951-1952	.	denotes	.
T12288	1953-1965	RB	denotes	Surprisingly
T12289	1965-1966	,	denotes	,
T12290	1967-1974	RB	denotes	however
T12291	1974-1975	,	denotes	,
T12292	1976-1981	NNP	denotes	Eomes
T12293	1982-1985	CC	denotes	and
T12294	1986-1991	NNP	denotes	T-bet
T12295	1992-2000	VBD	denotes	appeared
T12296	2001-2013	JJ	denotes	nonredundant
T12297	2014-2016	IN	denotes	in
T12298	2017-2022	PRP$	denotes	their
T12299	2023-2030	NN	denotes	ability
T12300	2031-2033	TO	denotes	to
T12301	2034-2040	VB	denotes	induce
T12302	2041-2044	CD	denotes	two
T12303	2045-2050	JJ	denotes	other
T12304	2051-2058	NNS	denotes	markers
T12305	2059-2061	IN	denotes	of
T12306	2062-2065	NNP	denotes	CTL
T12307	2066-2074	NN	denotes	function
T12308	2074-2075	,	denotes	,
T12309	2076-2080	NNP	denotes	Prf1
T12310	2081-2084	CC	denotes	and
T12311	2085-2089	NNP	denotes	Gzmb
T12312	2090-2091	-LRB-	denotes	(
T12313	2091-2095	NNP	denotes	Fig.
T12314	2096-2097	CD	denotes	4
T12315	2098-2099	NNP	denotes	C
T12316	2099-2100	-RRB-	denotes	)
T12317	2100-2101	.	denotes	.
T12318	2102-2108	RB	denotes	Rather
T12319	2108-2109	,	denotes	,
T12320	2110-2115	NN	denotes	T-bet
T12321	2116-2119	CC	denotes	and
T12322	2120-2125	NNS	denotes	Eomes
T12323	2126-2130	VBD	denotes	were
T12324	2131-2139	VBN	denotes	involved
T12325	2140-2142	IN	denotes	in
T12326	2143-2153	VBG	denotes	regulating
T12327	2154-2162	NN	denotes	granzyme
T12328	2163-2164	NN	denotes	B
T12329	2165-2168	CC	denotes	and
T12330	2169-2177	NN	denotes	perforin
T12331	2178-2188	NN	denotes	expression
T12332	2188-2189	,	denotes	,
T12333	2190-2202	RB	denotes	respectively
T12334	2202-2203	:	denotes	:
T12335	2204-2217	NN	denotes	up-regulation
T12336	2218-2220	IN	denotes	of
T12337	2221-2226	NNP	denotes	T-bet
T12338	2227-2230	CC	denotes	and
T12339	2231-2236	NNP	denotes	Eomes
T12340	2237-2241	NNP	denotes	mRNA
T12341	2242-2245	CC	denotes	and
T12342	2246-2253	NN	denotes	protein
T12343	2254-2261	RB	denotes	closely
T12344	2262-2270	VBD	denotes	preceded
T12345	2271-2284	NN	denotes	up-regulation
T12346	2285-2287	IN	denotes	of
T12347	2288-2292	NNP	denotes	Gzmb
T12348	2293-2296	CC	denotes	and
T12349	2297-2301	NNP	denotes	Prf1
T12350	2302-2306	NNP	denotes	mRNA
T12351	2307-2310	CC	denotes	and
T12352	2311-2318	NN	denotes	protein
T12353	2318-2319	,	denotes	,
T12354	2320-2332	RB	denotes	respectively
T12355	2332-2333	.	denotes	.
T12356	2334-2339	NN	denotes	T-bet
T12357	2340-2343	VBD	denotes	had
T12358	2344-2346	DT	denotes	no
T12359	2347-2351	NN	denotes	role
T12360	2352-2354	IN	denotes	in
T12361	2355-2363	NN	denotes	perforin
T12362	2364-2374	NN	denotes	expression
T12363	2375-2380	IN	denotes	under
T12364	2381-2384	PRP$	denotes	our
T12365	2385-2392	NN	denotes	culture
T12366	2393-2403	NNS	denotes	conditions
T12367	2403-2404	,	denotes	,
T12368	2405-2408	CC	denotes	and
T12369	2409-2416	NNP	denotes	Eo-VP16
T12370	2417-2420	VBD	denotes	did
T12371	2421-2424	RB	denotes	not
T12372	2425-2431	VB	denotes	affect
T12373	2432-2440	NN	denotes	granzyme
T12374	2441-2442	NNP	denotes	B
T12375	2443-2453	NN	denotes	expression
T12376	2454-2458	WRB	denotes	when
T12377	2459-2468	VBN	denotes	expressed
T12378	2469-2471	IN	denotes	in
T12379	2472-2477	NNP	denotes	T-bet
T12380	2477-2478	CD	denotes	−
T12381	2478-2479	CD	denotes	/
T12382	2479-2480	NN	denotes	−
T12383	2481-2483	CC	denotes	or
T12384	2484-2489	JJ	denotes	Runx3
T12385	2489-2490	NN	denotes	−
T12386	2490-2491	NN	denotes	/
T12387	2491-2492	NN	denotes	−
T12388	2493-2498	NNS	denotes	cells
T12389	2498-2499	.	denotes	.
T12390	2500-2507	IN	denotes	Because
T12391	2508-2520	JJ	denotes	conventional
T12392	2521-2536	JJ	denotes	Eomes-deficient
T12393	2537-2541	NNS	denotes	mice
T12394	2542-2545	VBP	denotes	die
T12395	2546-2552	IN	denotes	before
T12396	2553-2562	NN	denotes	precursor
T12397	2563-2568	NNS	denotes	cells
T12398	2569-2572	MD	denotes	can
T12399	2573-2575	VB	denotes	be
T12400	2576-2584	VBN	denotes	isolated
T12401	2585-2588	IN	denotes	for
T12402	2589-2593	NN	denotes	bone
T12403	2594-2600	NN	denotes	marrow
T12404	2601-2610	NNS	denotes	transfers
T12405	2611-2612	-LRB-	denotes	(
T12406	2612-2614	CD	denotes	27
T12407	2614-2615	-RRB-	denotes	)
T12408	2616-2619	CC	denotes	and
T12409	2620-2627	IN	denotes	because
T12410	2628-2629	NNP	denotes	T
T12411	2630-2635	NNS	denotes	cells
T12412	2636-2649	RB	denotes	conditionally
T12413	2650-2659	VBP	denotes	deficient
T12414	2660-2662	IN	denotes	in
T12415	2663-2668	NNS	denotes	Eomes
T12416	2669-2673	VBP	denotes	have
T12417	2674-2678	RB	denotes	only
T12418	2679-2687	RB	denotes	recently
T12419	2688-2692	VBN	denotes	been
T12420	2693-2702	VBN	denotes	described
T12421	2703-2704	-LRB-	denotes	(
T12422	2704-2705	CD	denotes	9
T12423	2705-2706	-RRB-	denotes	)
T12424	2706-2707	,	denotes	,
T12425	2708-2710	PRP	denotes	we
T12426	2711-2715	VBD	denotes	were
T12427	2716-2722	JJ	denotes	unable
T12428	2723-2725	TO	denotes	to
T12429	2726-2735	VB	denotes	introduce
T12430	2736-2741	JJ	denotes	Runx3
T12431	2742-2746	IN	denotes	into
T12432	2747-2762	JJ	denotes	Eomes-deficient
T12433	2763-2766	NNP	denotes	CD8
T12434	2766-2767	CD	denotes	+
T12435	2768-2769	NNP	denotes	T
T12436	2770-2775	NNS	denotes	cells
T12437	2776-2778	TO	denotes	to
T12438	2779-2783	VB	denotes	test
T12439	2784-2792	RB	denotes	formally
T12440	2793-2800	IN	denotes	whether
T12441	2801-2806	NNP	denotes	Eomes
T12442	2807-2817	VBD	denotes	cooperated
T12443	2818-2822	IN	denotes	with
T12444	2823-2828	JJ	denotes	Runx3
T12445	2829-2831	TO	denotes	to
T12446	2832-2838	VB	denotes	induce
T12447	2839-2847	JJ	denotes	perforin
T12448	2848-2858	NN	denotes	expression
T12449	2858-2859	.	denotes	.
T12450	2860-2872	RB	denotes	Collectively
T12451	2872-2873	,	denotes	,
T12452	2874-2877	PRP$	denotes	our
T12453	2878-2882	NNS	denotes	data
T12454	2883-2886	VBP	denotes	are
T12455	2887-2897	JJ	denotes	consistent
T12456	2898-2902	IN	denotes	with
T12457	2903-2904	DT	denotes	a
T12458	2905-2920	JJ	denotes	transcriptional
T12459	2921-2928	NN	denotes	network
T12460	2929-2931	IN	denotes	in
T12461	2932-2937	WDT	denotes	which
T12462	2938-2949	VBG	denotes	preexisting
T12463	2950-2955	JJ	denotes	Runx3
T12464	2956-2966	NNS	denotes	cooperates
T12465	2967-2971	IN	denotes	with
T12466	2972-2975	DT	denotes	the
T12467	2976-2983	JJ	denotes	induced
T12468	2984-2989	NN	denotes	T-box
T12469	2990-2997	NNS	denotes	factors
T12470	2998-3003	NNP	denotes	T-bet
T12471	3004-3007	CC	denotes	and
T12472	3008-3013	NNP	denotes	Eomes
T12473	3014-3017	CC	denotes	and
T12474	3018-3024	NNP	denotes	IL-2Rβ
T12475	3025-3032	NNS	denotes	signals
T12476	3033-3034	-LRB-	denotes	(
T12477	3034-3045	JJ	denotes	unpublished
T12478	3046-3050	NNS	denotes	data
T12479	3050-3051	-RRB-	denotes	)
T12480	3052-3054	TO	denotes	to
T12481	3055-3066	VB	denotes	orchestrate
T12482	3067-3070	NNP	denotes	CTL
T12483	3071-3086	NN	denotes	differentiation
T12484	3087-3088	-LRB-	denotes	(
T12485	3088-3092	JJ	denotes	Fig.
T12486	3093-3094	CD	denotes	4
T12487	3095-3096	NNP	denotes	C
T12488	3096-3097	-RRB-	denotes	)
T12489	3097-3098	.	denotes	.
T12490	3099-3102	PRP$	denotes	Our
T12491	3103-3107	NNS	denotes	data
T12492	3108-3114	VBP	denotes	recall
T12493	3115-3118	DT	denotes	the
T12494	3120-3132	JJ	denotes	feed-forward
T12495	3134-3145	NN	denotes	interaction
T12496	3146-3153	IN	denotes	between
T12497	3154-3159	NNP	denotes	T-bet
T12498	3160-3163	CC	denotes	and
T12499	3164-3169	NNP	denotes	Runx3
T12500	3170-3174	IN	denotes	that
T12501	3175-3177	PRP	denotes	we
T12502	3178-3188	RB	denotes	previously
T12503	3189-3198	VBD	denotes	described
T12504	3199-3201	IN	denotes	in
T12505	3202-3205	NNP	denotes	CD4
T12506	3205-3206	NNP	denotes	+
T12507	3207-3208	-LRB-	denotes	(
T12508	3208-3211	NNP	denotes	Th1
T12509	3211-3212	-RRB-	denotes	)
T12510	3213-3214	NNP	denotes	T
T12511	3215-3220	NNS	denotes	cells
T12512	3221-3222	-LRB-	denotes	(
T12513	3222-3224	CD	denotes	15
T12514	3224-3225	-RRB-	denotes	)
T12515	3226-3229	CC	denotes	but
T12516	3230-3233	VBP	denotes	are
T12517	3234-3242	JJ	denotes	distinct
T12518	3243-3245	IN	denotes	in
T12519	3246-3249	CD	denotes	two
T12520	3250-3258	NNS	denotes	respects
T12521	3258-3259	:	denotes	:
T12522	3260-3262	IN	denotes	in
T12523	3263-3278	VBG	denotes	differentiating
T12524	3279-3282	JJ	denotes	Th1
T12525	3283-3288	NNS	denotes	cells
T12526	3288-3289	,	denotes	,
T12527	3290-3295	NN	denotes	T-bet
T12528	3296-3298	VBZ	denotes	is
T12529	3299-3306	VBN	denotes	induced
T12530	3307-3309	IN	denotes	by
T12531	3310-3313	NNP	denotes	TCR
T12532	3314-3321	NNS	denotes	signals
T12533	3322-3325	CC	denotes	and
T12534	3326-3331	NNP	denotes	IFN-γ
T12535	3331-3332	,	denotes	,
T12536	3333-3336	CC	denotes	and
T12537	3337-3339	IN	denotes	in
T12538	3340-3344	NN	denotes	turn
T12539	3345-3352	VBZ	denotes	induces
T12540	3353-3358	NNP	denotes	Runx3
T12541	3359-3360	-LRB-	denotes	(
T12542	3360-3362	CD	denotes	15
T12543	3362-3363	-RRB-	denotes	)
T12544	3363-3364	,	denotes	,
T12545	3365-3372	IN	denotes	whereas
T12546	3373-3375	IN	denotes	in
T12547	3376-3391	VBG	denotes	differentiating
T12548	3392-3395	NNP	denotes	CD8
T12549	3395-3396	CD	denotes	+
T12550	3397-3398	NNP	denotes	T
T12551	3399-3404	NNS	denotes	cells
T12552	3404-3405	,	denotes	,
T12553	3406-3417	VBG	denotes	preexisting
T12554	3418-3423	NNP	denotes	Runx3
T12555	3424-3426	VBZ	denotes	is
T12556	3427-3435	VBN	denotes	required
T12557	3436-3438	TO	denotes	to
T12558	3439-3445	VB	denotes	induce
T12559	3446-3449	DT	denotes	the
T12560	3450-3455	NN	denotes	T-box
T12561	3456-3469	NN	denotes	transcription
T12562	3470-3476	NN	denotes	factor
T12563	3477-3482	NNP	denotes	Eomes
T12564	3482-3483	.	denotes	.
T12565	3484-3496	JJ	denotes	Whole-genome
T12566	3497-3508	NNS	denotes	experiments
T12567	3509-3511	IN	denotes	in
T12568	3512-3517	DT	denotes	these
T12569	3518-3521	CC	denotes	and
T12570	3522-3527	JJ	denotes	other
T12571	3528-3535	NNS	denotes	systems
T12572	3536-3540	MD	denotes	will
T12573	3541-3543	VB	denotes	be
T12574	3544-3552	VBN	denotes	required
T12575	3553-3555	TO	denotes	to
T12576	3556-3565	VB	denotes	establish
T12577	3566-3573	IN	denotes	whether
T12578	3574-3585	NN	denotes	cooperation
T12579	3586-3593	IN	denotes	between
T12580	3594-3599	NNP	denotes	T-box
T12581	3600-3603	CC	denotes	and
T12582	3604-3608	NNP	denotes	Runx
T12583	3609-3615	NN	denotes	family
T12584	3616-3629	NN	denotes	transcription
T12585	3630-3637	NNS	denotes	factors
T12586	3638-3640	VBZ	denotes	is
T12587	3641-3642	DT	denotes	a
T12588	3643-3650	JJ	denotes	general
T12589	3651-3658	NN	denotes	feature
T12590	3659-3661	IN	denotes	of
T12591	3662-3670	JJ	denotes	cellular
T12592	3671-3686	NN	denotes	differentiation
T12593	3687-3695	NNS	denotes	programs
T12594	3695-3696	.	denotes	.
R9306	T11912	T11915	amod	Runx3,factors
R9307	T11913	T11912	cc	and,Runx3
R9308	T11914	T11912	conj	T-box,Runx3
R9309	T11915	T11916	nsubj	factors,control
R9310	T11916	T11916	ROOT	control,control
R9311	T11917	T11919	det	a,program
R9312	T11918	T11919	amod	complex,program
R9313	T11919	T11916	dobj	program,control
R9314	T11920	T11919	prep	of,program
R9315	T11921	T11922	amod	transcriptional,regulation
R9316	T11922	T11920	pobj	regulation,of
R9317	T11923	T11916	prep	during,control
R9318	T11924	T11925	compound	CTL,differentiation
R9319	T11925	T11923	pobj	differentiation,during
R9320	T11926	T11930	advmod	Collectively,provide
R9321	T11927	T11930	punct	",",provide
R9322	T11928	T11929	det	these,data
R9323	T11929	T11930	nsubj	data,provide
R9324	T11930	T11930	ROOT	provide,provide
R9325	T11931	T11930	dobj	evidence,provide
R9326	T11932	T11940	mark	that,orchestrates
R9327	T11933	T11940	nsubj	Runx3,orchestrates
R9328	T11934	T11933	punct	",",Runx3
R9329	T11935	T11936	advmod	together,with
R9330	T11936	T11933	prep	with,Runx3
R9331	T11937	T11938	amod	T-box,factors
R9332	T11938	T11936	pobj	factors,with
R9333	T11939	T11940	punct	",",orchestrates
R9334	T11940	T11931	acl	orchestrates,evidence
R9335	T11941	T11943	det	a,program
R9336	T11942	T11943	amod	complex,program
R9337	T11943	T11940	dobj	program,orchestrates
R9338	T11944	T11943	prep	of,program
R9339	T11945	T11946	amod	transcriptional,regulation
R9340	T11946	T11944	pobj	regulation,of
R9341	T11947	T11946	prep	in,regulation
R9342	T11948	T11947	pcomp	differentiating,in
R9343	T11949	T11948	dobj	CTL,differentiating
R9344	T11950	T11953	punct	(,C
R9345	T11951	T11953	punct	Fig.,C
R9346	T11952	T11951	nummod	4,Fig.
R9347	T11953	T11949	appos	C,CTL
R9348	T11954	T11953	punct	),C
R9349	T11955	T11930	punct	.,provide
R9350	T11956	T11957	nsubj	Runx3,is
R9351	T11957	T11957	ROOT	is,is
R9352	T11958	T11957	acomp	present,is
R9353	T11959	T11958	prep	in,present
R9354	T11960	T11964	amod	naive,cells
R9355	T11961	T11964	nmod	CD8,cells
R9356	T11962	T11964	nummod	+,cells
R9357	T11963	T11964	compound	T,cells
R9358	T11964	T11959	pobj	cells,in
R9359	T11965	T11957	prep	before,is
R9360	T11966	T11965	pobj	activation,before
R9361	T11967	T11968	punct	(,12
R9362	T11968	T11966	appos	12,activation
R9363	T11969	T11957	punct	),is
R9364	T11970	T11957	punct	.,is
R9365	T11971	T11972	nsubj	It,represses
R9366	T11972	T11972	ROOT	represses,represses
R9367	T11973	T11972	dobj	Runx1,represses
R9368	T11974	T11972	cc	and,represses
R9369	T11975	T11972	conj	has,represses
R9370	T11976	T11978	det	a,role
R9371	T11977	T11978	amod	positive,role
R9372	T11978	T11975	dobj	role,has
R9373	T11979	T11978	prep	in,role
R9374	T11980	T11981	det	the,induction
R9375	T11981	T11979	pobj	induction,in
R9376	T11982	T11981	prep	of,induction
R9377	T11983	T11982	pobj	Eomes,of
R9378	T11984	T11978	punct	",",role
R9379	T11985	T11986	compound	granzyme,B
R9380	T11986	T11978	appos	B,role
R9381	T11987	T11986	punct	",",B
R9382	T11988	T11986	conj	perforin,B
R9383	T11989	T11988	punct	",",perforin
R9384	T11990	T11988	cc	and,perforin
R9385	T11991	T11988	conj	IFN-γ,perforin
R9386	T11992	T11972	punct	.,represses
R9387	T11993	T11994	amod	Runx3,binds
R9388	T11994	T11994	ROOT	binds,binds
R9389	T11995	T11994	prep	to,binds
R9390	T11996	T11995	pobj	promoters,to
R9391	T11997	T11996	cc	and,promoters
R9392	T11998	T12000	amod	putative,regions
R9393	T11999	T12000	amod	regulatory,regions
R9394	T12000	T11996	conj	regions,promoters
R9395	T12001	T12000	prep	of,regions
R9396	T12002	T12005	det	the,genes
R9397	T12003	T12005	amod	latter,genes
R9398	T12004	T12005	nummod	three,genes
R9399	T12005	T12001	pobj	genes,of
R9400	T12006	T11994	punct	",",binds
R9401	T12007	T11994	acl	suggesting,binds
R9402	T12008	T12010	det	a,effect
R9403	T12009	T12010	amod	direct,effect
R9404	T12010	T12007	dobj	effect,suggesting
R9405	T12011	T12010	prep	on,effect
R9406	T12012	T12013	compound	gene,expression
R9407	T12013	T12011	pobj	expression,on
R9408	T12014	T11994	punct	.,binds
R9409	T12015	T12016	amod	Additional,experiments
R9410	T12016	T12018	nsubjpass	experiments,needed
R9411	T12017	T12018	auxpass	are,needed
R9412	T12018	T12018	ROOT	needed,needed
R9413	T12019	T12020	aux	to,determine
R9414	T12020	T12018	advcl	determine,needed
R9415	T12021	T12025	mark	whether,are
R9416	T12022	T12025	nsubj	Eomes,are
R9417	T12023	T12022	cc	and,Eomes
R9418	T12024	T12022	conj	Runx1,Eomes
R9419	T12025	T12020	ccomp	are,determine
R9420	T12026	T12025	advmod	also,are
R9421	T12027	T12029	amod	direct,genes
R9422	T12028	T12029	compound	target,genes
R9423	T12029	T12025	attr	genes,are
R9424	T12030	T12029	prep	of,genes
R9425	T12031	T12030	pobj	Runx3,of
R9426	T12032	T12018	punct	.,needed
R9427	T12033	T12036	advmod	Surprisingly,contributed
R9428	T12034	T12036	punct	",",contributed
R9429	T12035	T12036	nsubj	Runx3,contributed
R9430	T12036	T12036	ROOT	contributed,contributed
R9431	T12037	T12036	prep	to,contributed
R9432	T12038	T12040	det	the,expression
R9433	T12039	T12040	amod	optimal,expression
R9434	T12040	T12037	pobj	expression,to
R9435	T12041	T12040	prep	of,expression
R9436	T12042	T12041	pobj	TNF,of
R9437	T12043	T12042	punct	",",TNF
R9438	T12044	T12042	conj	IL-2,TNF
R9439	T12045	T12044	punct	",",IL-2
R9440	T12046	T12044	cc	and,IL-2
R9441	T12047	T12044	conj	IFN-γ,IL-2
R9442	T12048	T12040	prep	at,expression
R9443	T12049	T12052	nmod	day,Fig
R9444	T12050	T12049	nummod	4,day
R9445	T12051	T12052	punct	(,Fig
R9446	T12052	T12048	pobj	Fig,at
R9447	T12053	T12036	punct	.,contributed
R9448	T12054	T12054	ROOT	S2,S2
R9449	T12055	T12054	punct	),S2
R9450	T12056	T12054	punct	.,S2
R9451	T12057	T12089	prep	For,/
R9452	T12058	T12057	pobj	TNF,For
R9453	T12059	T12058	cc	and,TNF
R9454	T12060	T12058	conj	IL-2,TNF
R9455	T12061	T12060	punct	",",IL-2
R9456	T12062	T12063	det	the,requirement
R9457	T12063	T12060	appos	requirement,IL-2
R9458	T12064	T12063	prep	for,requirement
R9459	T12065	T12066	amod	Runx3,subsides
R9460	T12066	T12064	pobj	subsides,for
R9461	T12067	T12066	prep	by,subsides
R9462	T12068	T12067	pobj	day,by
R9463	T12069	T12068	nummod	6,day
R9464	T12070	T12071	punct	(,Fig.
R9465	T12071	T12073	nmod	Fig.,C
R9466	T12072	T12071	nummod	3,Fig.
R9467	T12073	T12060	conj	C,IL-2
R9468	T12074	T12073	punct	),C
R9469	T12075	T12057	punct	",",For
R9470	T12076	T12077	advmod	possibly,because
R9471	T12077	T12089	prep	because,/
R9472	T12078	T12077	pcomp	of,because
R9473	T12079	T12077	pobj	compensation,because
R9474	T12080	T12079	prep	by,compensation
R9475	T12081	T12080	pobj	Runx1,by
R9476	T12082	T12081	punct	",",Runx1
R9477	T12083	T12084	nsubj	which,is
R9478	T12084	T12081	relcl	is,Runx1
R9479	T12085	T12084	attr	derepressed,is
R9480	T12086	T12085	prep	in,derepressed
R9481	T12087	T12088	compound	Runx3,−
R9482	T12088	T12086	pobj	−,in
R9483	T12089	T12089	ROOT	/,/
R9484	T12090	T12091	nummod	−,cells
R9485	T12091	T12089	dobj	cells,/
R9486	T12092	T12093	punct	(,Fig.
R9487	T12093	T12095	nmod	Fig.,A
R9488	T12094	T12095	nummod	4,A
R9489	T12095	T12091	appos	A,cells
R9490	T12096	T12091	punct	),cells
R9491	T12097	T12089	punct	.,/
R9492	T12098	T12099	nsubj	Runx3,continues
R9493	T12099	T12099	ROOT	continues,continues
R9494	T12100	T12102	aux	to,required
R9495	T12101	T12102	auxpass	be,required
R9496	T12102	T12099	xcomp	required,continues
R9497	T12103	T12102	prep	for,required
R9498	T12104	T12105	amod	IFN-γ,expression
R9499	T12105	T12103	pobj	expression,for
R9500	T12106	T12107	advmod	even,at
R9501	T12107	T12105	prep	at,expression
R9502	T12108	T12107	pobj	day,at
R9503	T12109	T12108	nummod	6,day
R9504	T12110	T12099	punct	",",continues
R9505	T12111	T12112	advmod	perhaps,because
R9506	T12112	T12099	prep	because,continues
R9507	T12113	T12112	pcomp	of,because
R9508	T12114	T12115	poss	its,role
R9509	T12115	T12112	pobj	role,because
R9510	T12116	T12115	prep	in,role
R9511	T12117	T12118	det	the,induction
R9512	T12118	T12116	pobj	induction,in
R9513	T12119	T12118	prep	of,induction
R9514	T12120	T12121	compound	Eomes,expression
R9515	T12121	T12119	pobj	expression,of
R9516	T12122	T12123	punct	(,Fig.
R9517	T12123	T12115	appos	Fig.,role
R9518	T12124	T12125	nummod	4,A
R9519	T12125	T12123	appos	A,Fig.
R9520	T12126	T12123	punct	),Fig.
R9521	T12127	T12099	punct	.,continues
R9522	T12128	T12130	det	An,finding
R9523	T12129	T12130	amod	unexpected,finding
R9524	T12130	T12131	nsubj	finding,was
R9525	T12131	T12131	ROOT	was,was
R9526	T12132	T12143	mark	that,are
R9527	T12133	T12137	det	the,factors
R9528	T12134	T12137	nummod	two,factors
R9529	T12135	T12137	amod	T-box,factors
R9530	T12136	T12137	compound	transcription,factors
R9531	T12137	T12143	nsubj	factors,are
R9532	T12138	T12137	punct	",",factors
R9533	T12139	T12137	appos	T-bet,factors
R9534	T12140	T12139	cc	and,T-bet
R9535	T12141	T12139	conj	Eomes,T-bet
R9536	T12142	T12143	punct	",",are
R9537	T12143	T12131	ccomp	are,was
R9538	T12144	T12143	acomp	up-regulated,are
R9539	T12145	T12144	prep	with,up-regulated
R9540	T12146	T12147	advmod	very,different
R9541	T12147	T12148	amod	different,kinetics
R9542	T12148	T12145	pobj	kinetics,with
R9543	T12149	T12148	prep	in,kinetics
R9544	T12150	T12153	nummod	CD8,cells
R9545	T12151	T12153	nummod	+,cells
R9546	T12152	T12153	compound	T,cells
R9547	T12153	T12149	pobj	cells,in
R9548	T12154	T12153	prep	under,cells
R9549	T12155	T12157	poss	our,conditions
R9550	T12156	T12157	compound	culture,conditions
R9551	T12157	T12154	pobj	conditions,under
R9552	T12158	T12143	cc	and,are
R9553	T12159	T12143	conj	have,are
R9554	T12160	T12161	amod	nonredundant,roles
R9555	T12161	T12159	dobj	roles,have
R9556	T12162	T12159	prep	in,have
R9557	T12163	T12165	det	the,expression
R9558	T12164	T12165	amod	subsequent,expression
R9559	T12165	T12162	pobj	expression,in
R9560	T12166	T12165	prep	of,expression
R9561	T12167	T12169	amod	key,proteins
R9562	T12168	T12169	compound	effector,proteins
R9563	T12169	T12166	pobj	proteins,of
R9564	T12170	T12173	punct	(,C
R9565	T12171	T12173	nmod	Fig.,C
R9566	T12172	T12171	nummod	4,Fig.
R9567	T12173	T12165	appos	C,expression
R9568	T12174	T12173	punct	),C
R9569	T12175	T12131	punct	.,was
R9570	T12176	T12178	nsubjpass	T-bet,needed
R9571	T12177	T12178	auxpass	is,needed
R9572	T12178	T12178	ROOT	needed,needed
R9573	T12179	T12178	advmod	early,needed
R9574	T12180	T12181	aux	to,confer
R9575	T12181	T12178	advcl	confer,needed
R9576	T12182	T12181	prep	on,confer
R9577	T12183	T12187	amod	activated,cells
R9578	T12184	T12186	compound	CD8,T
R9579	T12185	T12186	compound	+,T
R9580	T12186	T12187	compound	T,cells
R9581	T12187	T12182	pobj	cells,on
R9582	T12188	T12189	det	the,competence
R9583	T12189	T12181	dobj	competence,confer
R9584	T12190	T12191	aux	to,produce
R9585	T12191	T12189	relcl	produce,competence
R9586	T12192	T12191	dobj	IFN-γ,produce
R9587	T12193	T12191	prep	upon,produce
R9588	T12194	T12193	pobj	restimulation,upon
R9589	T12195	T12178	punct	",",needed
R9590	T12196	T12178	cc	but,needed
R9591	T12197	T12198	poss	its,function
R9592	T12198	T12199	nsubj	function,is
R9593	T12199	T12178	conj	is,needed
R9594	T12200	T12201	advmod	less,important
R9595	T12201	T12199	acomp	important,is
R9596	T12202	T12201	prep	at,important
R9597	T12203	T12204	amod	later,times
R9598	T12204	T12202	pobj	times,at
R9599	T12205	T12199	punct	.,is
R9600	T12206	T12219	nsubj	Eomes,substitute
R9601	T12207	T12206	punct	",",Eomes
R9602	T12208	T12210	nsubjpass	which,induced
R9603	T12209	T12210	auxpass	is,induced
R9604	T12210	T12206	relcl	induced,Eomes
R9605	T12211	T12210	advmod	late,induced
R9606	T12212	T12210	cc	and,induced
R9607	T12213	T12210	conj	functions,induced
R9608	T12214	T12213	amod	downstream,functions
R9609	T12215	T12214	prep	of,downstream
R9610	T12216	T12215	pobj	Runx3,of
R9611	T12217	T12219	punct	",",substitute
R9612	T12218	T12219	aux	may,substitute
R9613	T12219	T12219	ROOT	substitute,substitute
R9614	T12220	T12219	prep	for,substitute
R9615	T12221	T12220	pobj	T-bet,for
R9616	T12222	T12219	prep	in,substitute
R9617	T12223	T12222	pcomp	promoting,in
R9618	T12224	T12226	det	the,expression
R9619	T12225	T12226	amod	acute,expression
R9620	T12226	T12223	dobj	expression,promoting
R9621	T12227	T12226	prep	of,expression
R9622	T12228	T12227	pobj	IFN-γ,of
R9623	T12229	T12226	prep	in,expression
R9624	T12230	T12231	amod	restimulated,CTLs
R9625	T12231	T12229	pobj	CTLs,in
R9626	T12232	T12233	punct	(,8
R9627	T12233	T12226	appos	8,expression
R9628	T12234	T12226	punct	),expression
R9629	T12235	T12219	punct	.,substitute
R9630	T12236	T12242	advmod	Indeed,contribute
R9631	T12237	T12242	punct	",",contribute
R9632	T12238	T12242	nsubj	T-bet,contribute
R9633	T12239	T12238	cc	and,T-bet
R9634	T12240	T12238	conj	Eomes,T-bet
R9635	T12241	T12242	dep	both,contribute
R9636	T12242	T12242	ROOT	contribute,contribute
R9637	T12243	T12244	aux	to,perforin
R9638	T12244	T12242	xcomp	perforin,contribute
R9639	T12245	T12244	dobj	expression,perforin
R9640	T12246	T12244	prep	in,perforin
R9641	T12247	T12248	compound	NK,cells
R9642	T12248	T12246	pobj	cells,in
R9643	T12249	T12252	punct	(,26
R9644	T12250	T12252	nummod	8,26
R9645	T12251	T12252	punct	",",26
R9646	T12252	T12248	appos	26,cells
R9647	T12253	T12248	punct	),cells
R9648	T12254	T12244	punct	",",perforin
R9649	T12255	T12242	cc	and,contribute
R9650	T12256	T12257	nsubj	Eomes,induces
R9651	T12257	T12282	ccomp	induces,vary
R9652	T12258	T12259	compound	granzyme,B
R9653	T12259	T12257	dobj	B,induces
R9654	T12260	T12261	advmod	as,effectively
R9655	T12261	T12257	advmod	effectively,induces
R9656	T12262	T12257	prep	as,induces
R9657	T12263	T12262	pobj	T-bet,as
R9658	T12264	T12263	prep	in,T-bet
R9659	T12265	T12264	pcomp	developing,in
R9660	T12266	T12267	amod	Th2,cells
R9661	T12267	T12265	dobj	cells,developing
R9662	T12268	T12267	punct	(,cells
R9663	T12269	T12267	appos	7,cells
R9664	T12270	T12267	punct	),cells
R9665	T12271	T12257	punct	;,induces
R9666	T12272	T12282	advmod	thus,vary
R9667	T12273	T12282	punct	",",vary
R9668	T12274	T12276	det	the,roles
R9669	T12275	T12276	amod	relative,roles
R9670	T12276	T12282	nsubj	roles,vary
R9671	T12277	T12276	prep	of,roles
R9672	T12278	T12281	det	these,factors
R9673	T12279	T12281	amod	T-box,factors
R9674	T12280	T12281	compound	transcription,factors
R9675	T12281	T12277	pobj	factors,of
R9676	T12282	T12242	conj	vary,contribute
R9677	T12283	T12282	prep	depending,vary
R9678	T12284	T12283	prep	on,depending
R9679	T12285	T12286	compound	cell,type
R9680	T12286	T12284	pobj	type,on
R9681	T12287	T12282	punct	.,vary
R9682	T12288	T12295	advmod	Surprisingly,appeared
R9683	T12289	T12295	punct	",",appeared
R9684	T12290	T12295	advmod	however,appeared
R9685	T12291	T12295	punct	",",appeared
R9686	T12292	T12295	nsubj	Eomes,appeared
R9687	T12293	T12292	cc	and,Eomes
R9688	T12294	T12292	conj	T-bet,Eomes
R9689	T12295	T12295	ROOT	appeared,appeared
R9690	T12296	T12295	oprd	nonredundant,appeared
R9691	T12297	T12295	prep	in,appeared
R9692	T12298	T12299	poss	their,ability
R9693	T12299	T12297	pobj	ability,in
R9694	T12300	T12301	aux	to,induce
R9695	T12301	T12299	acl	induce,ability
R9696	T12302	T12304	nummod	two,markers
R9697	T12303	T12304	amod	other,markers
R9698	T12304	T12301	dobj	markers,induce
R9699	T12305	T12304	prep	of,markers
R9700	T12306	T12307	compound	CTL,function
R9701	T12307	T12305	pobj	function,of
R9702	T12308	T12307	punct	",",function
R9703	T12309	T12307	conj	Prf1,function
R9704	T12310	T12309	cc	and,Prf1
R9705	T12311	T12309	conj	Gzmb,Prf1
R9706	T12312	T12313	punct	(,Fig.
R9707	T12313	T12315	nmod	Fig.,C
R9708	T12314	T12315	nummod	4,C
R9709	T12315	T12309	conj	C,Prf1
R9710	T12316	T12315	punct	),C
R9711	T12317	T12295	punct	.,appeared
R9712	T12318	T12324	advmod	Rather,involved
R9713	T12319	T12324	punct	",",involved
R9714	T12320	T12324	nsubjpass	T-bet,involved
R9715	T12321	T12320	cc	and,T-bet
R9716	T12322	T12320	conj	Eomes,T-bet
R9717	T12323	T12324	auxpass	were,involved
R9718	T12324	T12344	ccomp	involved,preceded
R9719	T12325	T12324	prep	in,involved
R9720	T12326	T12325	pcomp	regulating,in
R9721	T12327	T12328	compound	granzyme,B
R9722	T12328	T12326	dobj	B,regulating
R9723	T12329	T12328	cc	and,B
R9724	T12330	T12331	compound	perforin,expression
R9725	T12331	T12328	conj	expression,B
R9726	T12332	T12326	punct	",",regulating
R9727	T12333	T12324	advmod	respectively,involved
R9728	T12334	T12324	punct	:,involved
R9729	T12335	T12344	nsubj	up-regulation,preceded
R9730	T12336	T12335	prep	of,up-regulation
R9731	T12337	T12336	pobj	T-bet,of
R9732	T12338	T12337	cc	and,T-bet
R9733	T12339	T12340	compound	Eomes,mRNA
R9734	T12340	T12337	conj	mRNA,T-bet
R9735	T12341	T12340	cc	and,mRNA
R9736	T12342	T12340	conj	protein,mRNA
R9737	T12343	T12344	advmod	closely,preceded
R9738	T12344	T12344	ROOT	preceded,preceded
R9739	T12345	T12344	dobj	up-regulation,preceded
R9740	T12346	T12345	prep	of,up-regulation
R9741	T12347	T12346	pobj	Gzmb,of
R9742	T12348	T12347	cc	and,Gzmb
R9743	T12349	T12350	compound	Prf1,mRNA
R9744	T12350	T12347	conj	mRNA,Gzmb
R9745	T12351	T12350	cc	and,mRNA
R9746	T12352	T12350	conj	protein,mRNA
R9747	T12353	T12344	punct	",",preceded
R9748	T12354	T12344	advmod	respectively,preceded
R9749	T12355	T12344	punct	.,preceded
R9750	T12356	T12357	nsubj	T-bet,had
R9751	T12357	T12357	ROOT	had,had
R9752	T12358	T12359	det	no,role
R9753	T12359	T12357	dobj	role,had
R9754	T12360	T12359	prep	in,role
R9755	T12361	T12362	amod	perforin,expression
R9756	T12362	T12360	pobj	expression,in
R9757	T12363	T12362	prep	under,expression
R9758	T12364	T12366	poss	our,conditions
R9759	T12365	T12366	compound	culture,conditions
R9760	T12366	T12363	pobj	conditions,under
R9761	T12367	T12357	punct	",",had
R9762	T12368	T12357	cc	and,had
R9763	T12369	T12372	nsubj	Eo-VP16,affect
R9764	T12370	T12372	aux	did,affect
R9765	T12371	T12372	neg	not,affect
R9766	T12372	T12357	conj	affect,had
R9767	T12373	T12375	amod	granzyme,expression
R9768	T12374	T12375	compound	B,expression
R9769	T12375	T12372	dobj	expression,affect
R9770	T12376	T12377	advmod	when,expressed
R9771	T12377	T12372	advcl	expressed,affect
R9772	T12378	T12377	prep	in,expressed
R9773	T12379	T12381	quantmod	T-bet,/
R9774	T12380	T12381	nummod	−,/
R9775	T12381	T12388	nummod	/,cells
R9776	T12382	T12388	nmod	−,cells
R9777	T12383	T12382	cc	or,−
R9778	T12384	T12382	conj	Runx3,−
R9779	T12385	T12388	compound	−,cells
R9780	T12386	T12388	compound	/,cells
R9781	T12387	T12388	compound	−,cells
R9782	T12388	T12378	pobj	cells,in
R9783	T12389	T12372	punct	.,affect
R9784	T12390	T12394	mark	Because,die
R9785	T12391	T12393	amod	conventional,mice
R9786	T12392	T12393	amod	Eomes-deficient,mice
R9787	T12393	T12394	nsubj	mice,die
R9788	T12394	T12426	advcl	die,were
R9789	T12395	T12400	mark	before,isolated
R9790	T12396	T12397	compound	precursor,cells
R9791	T12397	T12400	nsubjpass	cells,isolated
R9792	T12398	T12400	aux	can,isolated
R9793	T12399	T12400	auxpass	be,isolated
R9794	T12400	T12394	advcl	isolated,die
R9795	T12401	T12400	prep	for,isolated
R9796	T12402	T12403	compound	bone,marrow
R9797	T12403	T12404	compound	marrow,transfers
R9798	T12404	T12401	pobj	transfers,for
R9799	T12405	T12404	punct	(,transfers
R9800	T12406	T12404	appos	27,transfers
R9801	T12407	T12404	punct	),transfers
R9802	T12408	T12400	cc	and,isolated
R9803	T12409	T12413	mark	because,deficient
R9804	T12410	T12411	compound	T,cells
R9805	T12411	T12413	nsubj	cells,deficient
R9806	T12412	T12413	advmod	conditionally,deficient
R9807	T12413	T12394	advcl	deficient,die
R9808	T12414	T12413	prep	in,deficient
R9809	T12415	T12414	pobj	Eomes,in
R9810	T12416	T12420	aux	have,described
R9811	T12417	T12418	advmod	only,recently
R9812	T12418	T12420	advmod	recently,described
R9813	T12419	T12420	auxpass	been,described
R9814	T12420	T12394	conj	described,die
R9815	T12421	T12420	punct	(,described
R9816	T12422	T12420	npadvmod	9,described
R9817	T12423	T12420	punct	),described
R9818	T12424	T12426	punct	",",were
R9819	T12425	T12426	nsubj	we,were
R9820	T12426	T12426	ROOT	were,were
R9821	T12427	T12426	acomp	unable,were
R9822	T12428	T12429	aux	to,introduce
R9823	T12429	T12427	xcomp	introduce,unable
R9824	T12430	T12429	dobj	Runx3,introduce
R9825	T12431	T12429	prep	into,introduce
R9826	T12432	T12435	compound	Eomes-deficient,T
R9827	T12433	T12435	compound	CD8,T
R9828	T12434	T12435	compound	+,T
R9829	T12435	T12436	compound	T,cells
R9830	T12436	T12431	pobj	cells,into
R9831	T12437	T12438	aux	to,test
R9832	T12438	T12429	advcl	test,introduce
R9833	T12439	T12442	advmod	formally,cooperated
R9834	T12440	T12442	mark	whether,cooperated
R9835	T12441	T12442	nsubj	Eomes,cooperated
R9836	T12442	T12426	advcl	cooperated,were
R9837	T12443	T12442	prep	with,cooperated
R9838	T12444	T12443	pobj	Runx3,with
R9839	T12445	T12446	aux	to,induce
R9840	T12446	T12442	advcl	induce,cooperated
R9841	T12447	T12448	amod	perforin,expression
R9842	T12448	T12446	dobj	expression,induce
R9843	T12449	T12426	punct	.,were
R9844	T12450	T12454	advmod	Collectively,are
R9845	T12451	T12454	punct	",",are
R9846	T12452	T12453	poss	our,data
R9847	T12453	T12454	nsubj	data,are
R9848	T12454	T12454	ROOT	are,are
R9849	T12455	T12454	acomp	consistent,are
R9850	T12456	T12455	prep	with,consistent
R9851	T12457	T12459	det	a,network
R9852	T12458	T12459	amod	transcriptional,network
R9853	T12459	T12462	nsubj	network,preexisting
R9854	T12460	T12462	prep	in,preexisting
R9855	T12461	T12460	pobj	which,in
R9856	T12462	T12456	pobj	preexisting,with
R9857	T12463	T12464	amod	Runx3,cooperates
R9858	T12464	T12462	dobj	cooperates,preexisting
R9859	T12465	T12462	prep	with,preexisting
R9860	T12466	T12469	det	the,factors
R9861	T12467	T12469	amod	induced,factors
R9862	T12468	T12469	compound	T-box,factors
R9863	T12469	T12465	pobj	factors,with
R9864	T12470	T12475	nmod	T-bet,signals
R9865	T12471	T12470	cc	and,T-bet
R9866	T12472	T12470	conj	Eomes,T-bet
R9867	T12473	T12472	cc	and,Eomes
R9868	T12474	T12472	conj	IL-2Rβ,Eomes
R9869	T12475	T12469	appos	signals,factors
R9870	T12476	T12478	punct	(,data
R9871	T12477	T12478	amod	unpublished,data
R9872	T12478	T12475	appos	data,signals
R9873	T12479	T12475	punct	),signals
R9874	T12480	T12481	aux	to,orchestrate
R9875	T12481	T12475	advcl	orchestrate,signals
R9876	T12482	T12483	compound	CTL,differentiation
R9877	T12483	T12481	dobj	differentiation,orchestrate
R9878	T12484	T12487	punct	(,C
R9879	T12485	T12487	nsubj	Fig.,C
R9880	T12486	T12485	nummod	4,Fig.
R9881	T12487	T12475	appos	C,signals
R9882	T12488	T12454	punct	),are
R9883	T12489	T12454	punct	.,are
R9884	T12490	T12491	poss	Our,data
R9885	T12491	T12492	nsubj	data,recall
R9886	T12492	T12492	ROOT	recall,recall
R9887	T12493	T12495	det	the,interaction
R9888	T12494	T12495	amod	feed-forward,interaction
R9889	T12495	T12492	dobj	interaction,recall
R9890	T12496	T12495	prep	between,interaction
R9891	T12497	T12496	pobj	T-bet,between
R9892	T12498	T12497	cc	and,T-bet
R9893	T12499	T12497	conj	Runx3,T-bet
R9894	T12500	T12503	dobj	that,described
R9895	T12501	T12503	nsubj	we,described
R9896	T12502	T12503	advmod	previously,described
R9897	T12503	T12495	relcl	described,interaction
R9898	T12504	T12503	prep	in,described
R9899	T12505	T12506	compound	CD4,+
R9900	T12506	T12511	nmod	+,cells
R9901	T12507	T12506	punct	(,+
R9902	T12508	T12506	appos	Th1,+
R9903	T12509	T12506	punct	),+
R9904	T12510	T12511	compound	T,cells
R9905	T12511	T12504	pobj	cells,in
R9906	T12512	T12495	punct	(,interaction
R9907	T12513	T12495	appos	15,interaction
R9908	T12514	T12495	punct	),interaction
R9909	T12515	T12492	cc	but,recall
R9910	T12516	T12492	conj	are,recall
R9911	T12517	T12516	acomp	distinct,are
R9912	T12518	T12517	prep	in,distinct
R9913	T12519	T12520	nummod	two,respects
R9914	T12520	T12518	pobj	respects,in
R9915	T12521	T12529	punct	:,induced
R9916	T12522	T12529	prep	in,induced
R9917	T12523	T12522	pcomp	differentiating,in
R9918	T12524	T12525	amod	Th1,cells
R9919	T12525	T12523	dobj	cells,differentiating
R9920	T12526	T12529	punct	",",induced
R9921	T12527	T12529	nsubjpass	T-bet,induced
R9922	T12528	T12529	auxpass	is,induced
R9923	T12529	T12539	csubj	induced,induces
R9924	T12530	T12529	agent	by,induced
R9925	T12531	T12532	compound	TCR,signals
R9926	T12532	T12530	pobj	signals,by
R9927	T12533	T12532	cc	and,signals
R9928	T12534	T12532	conj	IFN-γ,signals
R9929	T12535	T12534	punct	",",IFN-γ
R9930	T12536	T12530	cc	and,by
R9931	T12537	T12539	prep	in,induces
R9932	T12538	T12537	pobj	turn,in
R9933	T12539	T12539	ROOT	induces,induces
R9934	T12540	T12539	dobj	Runx3,induces
R9935	T12541	T12540	punct	(,Runx3
R9936	T12542	T12540	appos	15,Runx3
R9937	T12543	T12540	punct	),Runx3
R9938	T12544	T12539	punct	",",induces
R9939	T12545	T12556	mark	whereas,required
R9940	T12546	T12556	prep	in,required
R9941	T12547	T12546	pcomp	differentiating,in
R9942	T12548	T12551	nmod	CD8,cells
R9943	T12549	T12551	nummod	+,cells
R9944	T12550	T12551	compound	T,cells
R9945	T12551	T12547	dobj	cells,differentiating
R9946	T12552	T12556	punct	",",required
R9947	T12553	T12554	compound	preexisting,Runx3
R9948	T12554	T12556	nsubjpass	Runx3,required
R9949	T12555	T12556	auxpass	is,required
R9950	T12556	T12539	advcl	required,induces
R9951	T12557	T12558	aux	to,induce
R9952	T12558	T12556	advcl	induce,required
R9953	T12559	T12562	det	the,factor
R9954	T12560	T12562	compound	T-box,factor
R9955	T12561	T12562	compound	transcription,factor
R9956	T12562	T12558	dobj	factor,induce
R9957	T12563	T12562	appos	Eomes,factor
R9958	T12564	T12539	punct	.,induces
R9959	T12565	T12566	amod	Whole-genome,experiments
R9960	T12566	T12574	nsubjpass	experiments,required
R9961	T12567	T12566	prep	in,experiments
R9962	T12568	T12571	det	these,systems
R9963	T12569	T12571	nummod	and,systems
R9964	T12570	T12571	amod	other,systems
R9965	T12571	T12567	pobj	systems,in
R9966	T12572	T12574	aux	will,required
R9967	T12573	T12574	auxpass	be,required
R9968	T12574	T12574	ROOT	required,required
R9969	T12575	T12576	aux	to,establish
R9970	T12576	T12574	advcl	establish,required
R9971	T12577	T12586	mark	whether,is
R9972	T12578	T12586	nsubj	cooperation,is
R9973	T12579	T12578	prep	between,cooperation
R9974	T12580	T12585	nmod	T-box,factors
R9975	T12581	T12580	cc	and,T-box
R9976	T12582	T12580	conj	Runx,T-box
R9977	T12583	T12584	compound	family,transcription
R9978	T12584	T12585	compound	transcription,factors
R9979	T12585	T12579	pobj	factors,between
R9980	T12586	T12576	ccomp	is,establish
R9981	T12587	T12589	det	a,feature
R9982	T12588	T12589	amod	general,feature
R9983	T12589	T12586	attr	feature,is
R9984	T12590	T12589	prep	of,feature
R9985	T12591	T12593	amod	cellular,programs
R9986	T12592	T12593	compound	differentiation,programs
R9987	T12593	T12590	pobj	programs,of
R9988	T12594	T12574	punct	.,required

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T11594	2589-2600	http://purl.obolibrary.org/obo/UBERON_0002371	denotes	bone marrow

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T11908	53-68	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T11909	224-239	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T11910	2905-2920	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T11911	3456-3469	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T12715	3616-3629	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T12716	53-86	http://purl.obolibrary.org/obo/GO_0045896	denotes	transcriptional regulation during
T12717	69-79	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T12718	240-250	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T12719	2207-2217	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T12720	2274-2284	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T12721	566-581	http://purl.obolibrary.org/obo/GO_0010467	denotes	gene expression
T12722	3025-3032	http://purl.obolibrary.org/obo/GO_0023052	denotes	signals
T12723	3314-3321	http://purl.obolibrary.org/obo/GO_0023052	denotes	signals
T12724	3310-3313	http://purl.obolibrary.org/obo/GO_0006283	denotes	TCR
T12725	3662-3670	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T12726	759-763	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2
T12727	807-811	http://purl.obolibrary.org/obo/GO_0005134	denotes	IL-2

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T12728	319-324	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12729	945-950	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12730	1248-1253	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12731	1429-1434	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12732	1765-1770	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12733	1851-1856	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12734	2493-2498	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12735	2563-2568	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12736	2630-2635	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12737	2770-2775	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12738	3215-3220	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12739	3283-3288	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12740	3399-3404	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T12741	3310-3313	http://purl.obolibrary.org/obo/GO_0042101	denotes	TCR

sentences

Id	Subject	Object	Predicate	Lexical cue
T11889	0-106	Sentence	denotes	Runx3 and T-box factors control a complex program of transcriptional regulation during CTL differentiation
T11890	107-285	Sentence	denotes	Collectively, these data provide evidence that Runx3, together with T-box factors, orchestrates a complex program of transcriptional regulation in differentiating CTL (Fig. 4 C).
T11891	286-348	Sentence	denotes	Runx3 is present in naive CD8+ T cells before activation (12).
T11892	349-451	Sentence	denotes	It represses Runx1 and has a positive role in the induction of Eomes, granzyme B, perforin, and IFN-γ.
T11893	452-582	Sentence	denotes	Runx3 binds to promoters and putative regulatory regions of the latter three genes, suggesting a direct effect on gene expression.
T11894	583-692	Sentence	denotes	Additional experiments are needed to determine whether Eomes and Runx1 are also direct target genes of Runx3.
T11895	693-794	Sentence	denotes	Surprisingly, Runx3 contributed to the optimal expression of TNF, IL-2, and IFN-γ at day 4 (Fig. S2).
T11896	795-962	Sentence	denotes	For TNF and IL-2, the requirement for Runx3 subsides by day 6 (Fig. 3 C), possibly because of compensation by Runx1, which is derepressed in Runx3−/− cells (Fig. 4 A).
T11897	963-1106	Sentence	denotes	Runx3 continues to be required for IFN-γ expression even at day 6, perhaps because of its role in the induction of Eomes expression (Fig. 4 A).
T11898	1107-1376	Sentence	denotes	An unexpected finding was that the two T-box transcription factors, T-bet and Eomes, are up-regulated with very different kinetics in CD8+ T cells under our culture conditions and have nonredundant roles in the subsequent expression of key effector proteins (Fig. 4 C).
T11899	1377-1537	Sentence	denotes	T-bet is needed early to confer on activated CD8+ T cells the competence to produce IFN-γ upon restimulation, but its function is less important at later times.
T11900	1538-1695	Sentence	denotes	Eomes, which is induced late and functions downstream of Runx3, may substitute for T-bet in promoting the acute expression of IFN-γ in restimulated CTLs (8).
T11901	1696-1952	Sentence	denotes	Indeed, T-bet and Eomes both contribute to perforin expression in NK cells (8, 26), and Eomes induces granzyme B as effectively as T-bet in developing Th2 cells (7); thus, the relative roles of these T-box transcription factors vary depending on cell type.
T11902	1953-2101	Sentence	denotes	Surprisingly, however, Eomes and T-bet appeared nonredundant in their ability to induce two other markers of CTL function, Prf1 and Gzmb (Fig. 4 C).
T11903	2102-2333	Sentence	denotes	Rather, T-bet and Eomes were involved in regulating granzyme B and perforin expression, respectively: up-regulation of T-bet and Eomes mRNA and protein closely preceded up-regulation of Gzmb and Prf1 mRNA and protein, respectively.
T11904	2334-2499	Sentence	denotes	T-bet had no role in perforin expression under our culture conditions, and Eo-VP16 did not affect granzyme B expression when expressed in T-bet−/− or Runx3−/− cells.
T11905	2500-2859	Sentence	denotes	Because conventional Eomes-deficient mice die before precursor cells can be isolated for bone marrow transfers (27) and because T cells conditionally deficient in Eomes have only recently been described (9), we were unable to introduce Runx3 into Eomes-deficient CD8+ T cells to test formally whether Eomes cooperated with Runx3 to induce perforin expression.
T11906	2860-3098	Sentence	denotes	Collectively, our data are consistent with a transcriptional network in which preexisting Runx3 cooperates with the induced T-box factors T-bet and Eomes and IL-2Rβ signals (unpublished data) to orchestrate CTL differentiation (Fig. 4 C).
T11907	3099-3696	Sentence	denotes	Our data recall the “feed-forward” interaction between T-bet and Runx3 that we previously described in CD4+ (Th1) T cells (15) but are distinct in two respects: in differentiating Th1 cells, T-bet is induced by TCR signals and IFN-γ, and in turn induces Runx3 (15), whereas in differentiating CD8+ T cells, preexisting Runx3 is required to induce the T-box transcription factor Eomes. Whole-genome experiments in these and other systems will be required to establish whether cooperation between T-box and Runx family transcription factors is a general feature of cellular differentiation programs.
T126	0-106	Sentence	denotes	Runx3 and T-box factors control a complex program of transcriptional regulation during CTL differentiation
T127	107-285	Sentence	denotes	Collectively, these data provide evidence that Runx3, together with T-box factors, orchestrates a complex program of transcriptional regulation in differentiating CTL (Fig. 4 C).
T128	286-348	Sentence	denotes	Runx3 is present in naive CD8+ T cells before activation (12).
T129	349-451	Sentence	denotes	It represses Runx1 and has a positive role in the induction of Eomes, granzyme B, perforin, and IFN-γ.
T130	452-582	Sentence	denotes	Runx3 binds to promoters and putative regulatory regions of the latter three genes, suggesting a direct effect on gene expression.
T131	583-692	Sentence	denotes	Additional experiments are needed to determine whether Eomes and Runx1 are also direct target genes of Runx3.
T132	693-794	Sentence	denotes	Surprisingly, Runx3 contributed to the optimal expression of TNF, IL-2, and IFN-γ at day 4 (Fig. S2).
T133	795-962	Sentence	denotes	For TNF and IL-2, the requirement for Runx3 subsides by day 6 (Fig. 3 C), possibly because of compensation by Runx1, which is derepressed in Runx3−/− cells (Fig. 4 A).
T134	963-1106	Sentence	denotes	Runx3 continues to be required for IFN-γ expression even at day 6, perhaps because of its role in the induction of Eomes expression (Fig. 4 A).
T135	1107-1376	Sentence	denotes	An unexpected finding was that the two T-box transcription factors, T-bet and Eomes, are up-regulated with very different kinetics in CD8+ T cells under our culture conditions and have nonredundant roles in the subsequent expression of key effector proteins (Fig. 4 C).
T136	1377-1537	Sentence	denotes	T-bet is needed early to confer on activated CD8+ T cells the competence to produce IFN-γ upon restimulation, but its function is less important at later times.
T137	1538-1695	Sentence	denotes	Eomes, which is induced late and functions downstream of Runx3, may substitute for T-bet in promoting the acute expression of IFN-γ in restimulated CTLs (8).
T138	1696-1952	Sentence	denotes	Indeed, T-bet and Eomes both contribute to perforin expression in NK cells (8, 26), and Eomes induces granzyme B as effectively as T-bet in developing Th2 cells (7); thus, the relative roles of these T-box transcription factors vary depending on cell type.
T139	1953-2101	Sentence	denotes	Surprisingly, however, Eomes and T-bet appeared nonredundant in their ability to induce two other markers of CTL function, Prf1 and Gzmb (Fig. 4 C).
T140	2102-2333	Sentence	denotes	Rather, T-bet and Eomes were involved in regulating granzyme B and perforin expression, respectively: up-regulation of T-bet and Eomes mRNA and protein closely preceded up-regulation of Gzmb and Prf1 mRNA and protein, respectively.
T141	2334-2499	Sentence	denotes	T-bet had no role in perforin expression under our culture conditions, and Eo-VP16 did not affect granzyme B expression when expressed in T-bet−/− or Runx3−/− cells.
T142	2500-2859	Sentence	denotes	Because conventional Eomes-deficient mice die before precursor cells can be isolated for bone marrow transfers (27) and because T cells conditionally deficient in Eomes have only recently been described (9), we were unable to introduce Runx3 into Eomes-deficient CD8+ T cells to test formally whether Eomes cooperated with Runx3 to induce perforin expression.
T143	2860-3098	Sentence	denotes	Collectively, our data are consistent with a transcriptional network in which preexisting Runx3 cooperates with the induced T-box factors T-bet and Eomes and IL-2Rβ signals (unpublished data) to orchestrate CTL differentiation (Fig. 4 C).
T144	3099-3483	Sentence	denotes	Our data recall the “feed-forward” interaction between T-bet and Runx3 that we previously described in CD4+ (Th1) T cells (15) but are distinct in two respects: in differentiating Th1 cells, T-bet is induced by TCR signals and IFN-γ, and in turn induces Runx3 (15), whereas in differentiating CD8+ T cells, preexisting Runx3 is required to induce the T-box transcription factor Eomes.
T145	3484-3696	Sentence	denotes	Whole-genome experiments in these and other systems will be required to establish whether cooperation between T-box and Runx family transcription factors is a general feature of cellular differentiation programs.

events-check-again

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T13502	0-5	Protein	denotes	Runx3
T13503	154-159	Protein	denotes	Runx3
T13504	286-291	Protein	denotes	Runx3
T13505	295-302	Gene_expression	denotes	present
T13506	312-315	Protein	denotes	CD8
T13507	352-361	Negative_regulation	denotes	represses
T13508	362-367	Protein	denotes	Runx1
T13509	372-391	Positive_regulation	denotes	has a positive role
T13510	372-391	Positive_regulation	denotes	has a positive role
T13511	372-391	Positive_regulation	denotes	has a positive role
T13512	372-391	Positive_regulation	denotes	has a positive role
T13513	399-408	Positive_regulation	denotes	induction
T13514	399-408	Positive_regulation	denotes	induction
T13515	399-408	Positive_regulation	denotes	induction
T13516	399-408	Positive_regulation	denotes	induction
T13517	412-417	Protein	denotes	Eomes
T13518	419-429	Protein	denotes	granzyme B
T13519	431-439	Protein	denotes	perforin
T13520	445-450	Protein	denotes	IFN-γ
T13521	452-457	Protein	denotes	Runx3
T13522	458-463	Binding	denotes	binds
T13523	458-463	Binding	denotes	binds
T13524	458-463	Binding	denotes	binds
T13525	458-463	Binding	denotes	binds
T13526	458-463	Binding	denotes	binds
T13527	458-463	Binding	denotes	binds
T13528	467-476	Entity	denotes	promoters
T13529	490-508	Entity	denotes	regulatory regions
T13530	556-562	Regulation	denotes	effect		true
T13531	556-562	Regulation	denotes	effect		true
T13532	556-562	Regulation	denotes	effect		true
T13533	571-581	Gene_expression	denotes	expression
T13534	571-581	Gene_expression	denotes	expression
T13535	571-581	Gene_expression	denotes	expression
T13536	638-643	Protein	denotes	Eomes
T13537	648-653	Protein	denotes	Runx1
T13538	670-676	Binding	denotes	target		true
T13539	670-676	Binding	denotes	target		true
T13540	686-691	Protein	denotes	Runx3
T13541	707-712	Protein	denotes	Runx3
T13542	713-724	Positive_regulation	denotes	contributed
T13543	713-724	Positive_regulation	denotes	contributed
T13544	713-724	Positive_regulation	denotes	contributed
T13545	740-750	Gene_expression	denotes	expression
T13546	740-750	Gene_expression	denotes	expression
T13547	740-750	Gene_expression	denotes	expression
T13548	754-757	Protein	denotes	TNF
T13549	759-763	Protein	denotes	IL-2
T13550	769-774	Protein	denotes	IFN-γ
T13551	799-802	Protein	denotes	TNF
T13552	807-811	Protein	denotes	IL-2
T13553	817-828	Positive_regulation	denotes	requirement
T13554	817-828	Positive_regulation	denotes	requirement
T13555	833-838	Protein	denotes	Runx3
T13556	839-847	Negative_regulation	denotes	subsides
T13557	839-847	Negative_regulation	denotes	subsides
T13558	905-910	Protein	denotes	Runx1
T13559	921-932	Negative_regulation	denotes	derepressed	true
T13560	936-941	Protein	denotes	Runx3
T13561	963-968	Protein	denotes	Runx3
T13562	985-993	Positive_regulation	denotes	required
T13563	998-1003	Protein	denotes	IFN-γ
T13564	1004-1014	Gene_expression	denotes	expression
T13565	1053-1057	Regulation	denotes	role		true
T13566	1065-1074	Positive_regulation	denotes	induction
T13567	1078-1083	Protein	denotes	Eomes
T13568	1084-1094	Gene_expression	denotes	expression
T13569	1175-1180	Protein	denotes	T-bet
T13570	1185-1190	Protein	denotes	Eomes
T13571	1196-1208	Positive_regulation	denotes	up-regulated
T13572	1196-1208	Positive_regulation	denotes	up-regulated
T13573	1241-1244	Protein	denotes	CD8
T13574	1377-1382	Protein	denotes	T-bet
T13575	1386-1392	Positive_regulation	denotes	needed
T13576	1422-1425	Protein	denotes	CD8
T13577	1453-1460	Gene_expression	denotes	produce
T13578	1461-1466	Protein	denotes	IFN-γ
T13579	1538-1543	Protein	denotes	Eomes
T13580	1554-1561	Positive_regulation	denotes	induced
T13581	1571-1591	Regulation	denotes	functions downstream
T13582	1595-1600	Protein	denotes	Runx3
T13583	1621-1626	Protein	denotes	T-bet
T13584	1630-1639	Positive_regulation	denotes	promoting		true
T13585	1630-1639	Positive_regulation	denotes	promoting		true
T13586	1650-1660	Gene_expression	denotes	expression
T13587	1664-1669	Protein	denotes	IFN-γ
T13588	1704-1709	Protein	denotes	T-bet
T13589	1714-1719	Protein	denotes	Eomes
T13590	1725-1735	Positive_regulation	denotes	contribute
T13591	1725-1735	Positive_regulation	denotes	contribute
T13592	1739-1747	Protein	denotes	perforin
T13593	1748-1758	Gene_expression	denotes	expression
T13594	1784-1789	Protein	denotes	Eomes
T13595	1790-1797	Positive_regulation	denotes	induces
T13596	1790-1797	Positive_regulation	denotes	induces
T13597	1798-1808	Protein	denotes	granzyme B
T13598	1827-1832	Protein	denotes	T-bet
T13599	1976-1981	Protein	denotes	Eomes
T13600	1986-1991	Protein	denotes	T-bet
T13601	2034-2040	Positive_regulation	denotes	induce
T13602	2034-2040	Positive_regulation	denotes	induce
T13603	2034-2040	Positive_regulation	denotes	induce
T13604	2034-2040	Positive_regulation	denotes	induce
T13605	2076-2080	Protein	denotes	Prf1
T13606	2085-2089	Protein	denotes	Gzmb
T13607	2110-2115	Protein	denotes	T-bet
T13608	2120-2125	Protein	denotes	Eomes
T13609	2143-2153	Regulation	denotes	regulating
T13610	2143-2153	Regulation	denotes	regulating
T13611	2154-2164	Protein	denotes	granzyme B
T13612	2169-2177	Protein	denotes	perforin
T13613	2178-2188	Gene_expression	denotes	expression
T13614	2178-2188	Gene_expression	denotes	expression
T13615	2204-2217	Positive_regulation	denotes	up-regulation
T13616	2204-2217	Positive_regulation	denotes	up-regulation
T13617	2221-2226	Protein	denotes	T-bet
T13618	2231-2236	Protein	denotes	Eomes
T13619	2262-2270	Positive_regulation	denotes	preceded
T13620	2262-2270	Positive_regulation	denotes	preceded
T13621	2271-2284	Positive_regulation	denotes	up-regulation
T13622	2271-2284	Positive_regulation	denotes	up-regulation
T13623	2288-2292	Protein	denotes	Gzmb
T13624	2297-2301	Protein	denotes	Prf1
T13625	2334-2339	Protein	denotes	T-bet
T13626	2340-2351	Regulation	denotes	had no role
T13627	2355-2363	Protein	denotes	perforin
T13628	2364-2374	Gene_expression	denotes	expression
T13629	2409-2416	Protein	denotes	Eo-VP16
T13630	2425-2431	Regulation	denotes	affect	true
T13631	2432-2442	Protein	denotes	granzyme B
T13632	2443-2453	Gene_expression	denotes	expression
T13633	2459-2468	Gene_expression	denotes	expressed
T13634	2472-2477	Protein	denotes	T-bet
T13635	2484-2489	Protein	denotes	Runx3
T13636	2521-2526	Protein	denotes	Eomes
T13637	2527-2536	Negative_regulation	denotes	deficient
T13638	2650-2659	Negative_regulation	denotes	deficient
T13639	2663-2668	Protein	denotes	Eomes
T13640	2736-2741	Protein	denotes	Runx3
T13641	2747-2752	Protein	denotes	Eomes
T13642	2753-2762	Negative_regulation	denotes	deficient
T13643	2763-2766	Protein	denotes	CD8
T13644	2801-2806	Protein	denotes	Eomes
T13645	2823-2828	Protein	denotes	Runx3
T13646	2832-2838	Positive_regulation	denotes	induce		true
T13647	2832-2838	Positive_regulation	denotes	induce		true
T13648	2839-2847	Protein	denotes	perforin
T13649	2848-2858	Gene_expression	denotes	expression
T13650	2950-2955	Protein	denotes	Runx3
T13651	2976-2983	Positive_regulation	denotes	induced
T13652	2976-2983	Positive_regulation	denotes	induced
T13653	2998-3003	Protein	denotes	T-bet
T13654	3008-3013	Protein	denotes	Eomes
T13655	3018-3024	Protein	denotes	IL-2Rβ
T13656	3134-3145	Regulation	denotes	interaction
T13657	3134-3145	Regulation	denotes	interaction
T13658	3134-3145	Regulation	denotes	interaction
T13659	3134-3145	Regulation	denotes	interaction
T13660	3154-3159	Protein	denotes	T-bet
T13661	3164-3169	Protein	denotes	Runx3
T13662	3202-3205	Protein	denotes	CD4
T13663	3290-3295	Protein	denotes	T-bet
T13664	3299-3306	Positive_regulation	denotes	induced
T13665	3326-3331	Protein	denotes	IFN-γ
T13666	3345-3352	Positive_regulation	denotes	induces
T13667	3353-3358	Protein	denotes	Runx3
T13668	3392-3395	Protein	denotes	CD8
T13669	3418-3423	Protein	denotes	Runx3
T13670	3427-3435	Positive_regulation	denotes	required
T13671	3439-3445	Positive_regulation	denotes	induce
T13672	3477-3482	Protein	denotes	Eomes
R10638	T13541	T13543	causeOf	Runx3,contributed
R10639	T13545	T13543	themeOf	expression,contributed
R10644	T13550	T13545	themeOf	IFN-γ,expression
R10645	T13551	T13554	themeOf	TNF,requirement
R10646	T13552	T13553	themeOf	IL-2,requirement
R10647	T13553	T13557	themeOf	requirement,subsides
R10648	T13554	T13556	themeOf	requirement,subsides
R10649	T13555	T13554	causeOf	Runx3,requirement
R10650	T13555	T13553	causeOf	Runx3,requirement
R10651	T13558	T13556	causeOf	Runx1,subsides
R10652	T13558	T13557	causeOf	Runx1,subsides
R10653	T13558	T13559	themeOf	Runx1,derepressed
R10654	T13561	T13562	causeOf	Runx3,required
R10655	T13561	T13565	causeOf	Runx3,role
R10656	T13563	T13564	themeOf	IFN-γ,expression
R10657	T13564	T13562	themeOf	expression,required
R10658	T13566	T13565	themeOf	induction,role
R10590	T13504	T13505	themeOf	Runx3,present
R10591	T13504	T13507	causeOf	Runx3,represses
R10592	T13504	T13511	causeOf	Runx3,has a positive role
R10593	T13504	T13512	causeOf	Runx3,has a positive role
R10594	T13504	T13509	causeOf	Runx3,has a positive role
R10595	T13504	T13510	causeOf	Runx3,has a positive role
R10596	T13508	T13507	themeOf	Runx1,represses
R10597	T13513	T13512	themeOf	induction,has a positive role
R10598	T13514	T13510	themeOf	induction,has a positive role
R10599	T13515	T13509	themeOf	induction,has a positive role
R10600	T13516	T13511	themeOf	induction,has a positive role
R10601	T13517	T13516	themeOf	Eomes,induction
R10602	T13518	T13513	themeOf	granzyme B,induction
R10603	T13518	T13535	themeOf	granzyme B,expression
R10604	T13519	T13515	themeOf	perforin,induction
R10605	T13519	T13533	themeOf	perforin,expression
R10606	T13520	T13514	themeOf	IFN-γ,induction
R10607	T13520	T13534	themeOf	IFN-γ,expression
R10608	T13521	T13522	themeOf	Runx3,binds
R10609	T13521	T13524	themeOf	Runx3,binds
R10610	T13521	T13525	themeOf	Runx3,binds
R10611	T13521	T13527	themeOf	Runx3,binds
R10612	T13521	T13526	themeOf	Runx3,binds
R10613	T13521	T13523	themeOf	Runx3,binds
R10614	T13521	T13531	causeOf	Runx3,effect
R10615	T13521	T13530	causeOf	Runx3,effect
R10616	T13521	T13532	causeOf	Runx3,effect
R10617	T13528	T13522	themeOf	promoters,binds
R10618	T13528	T13518	partOf	promoters,granzyme B
R10619	T13528	T13524	themeOf	promoters,binds
R10620	T13528	T13519	partOf	promoters,perforin
R10621	T13528	T13525	themeOf	promoters,binds
R10622	T13528	T13520	partOf	promoters,IFN-γ
R10623	T13529	T13527	themeOf	regulatory regions,binds
R10624	T13529	T13518	partOf	regulatory regions,granzyme B
R10625	T13529	T13526	themeOf	regulatory regions,binds
R10626	T13529	T13519	partOf	regulatory regions,perforin
R10627	T13529	T13523	themeOf	regulatory regions,binds
R10628	T13529	T13520	partOf	regulatory regions,IFN-γ
R10629	T13533	T13530	themeOf	expression,effect
R10630	T13534	T13532	themeOf	expression,effect
R10631	T13535	T13531	themeOf	expression,effect
R10632	T13536	T13539	themeOf	Eomes,target
R10633	T13537	T13538	themeOf	Runx1,target
R10634	T13540	T13539	themeOf	Runx3,target
R10635	T13540	T13538	themeOf	Runx3,target
R10636	T13541	T13542	causeOf	Runx3,contributed
R10637	T13541	T13544	causeOf	Runx3,contributed
R10640	T13546	T13544	themeOf	expression,contributed
R10641	T13547	T13542	themeOf	expression,contributed
R10642	T13548	T13547	themeOf	TNF,expression
R10643	T13549	T13546	themeOf	IL-2,expression
R10679	T13594	T13596	causeOf	Eomes,induces
R10680	T13597	T13595	themeOf	granzyme B,induces
R10682	T13598	T13595	causeOf	T-bet,induces
R10683	T13599	T13604	causeOf	Eomes,induce
R10684	T13599	T13601	causeOf	Eomes,induce
R10685	T13600	T13602	causeOf	T-bet,induce
R10686	T13600	T13603	causeOf	T-bet,induce
R10687	T13605	T13604	themeOf	Prf1,induce
R10688	T13605	T13602	themeOf	Prf1,induce
R10689	T13606	T13601	themeOf	Gzmb,induce
R10690	T13606	T13603	themeOf	Gzmb,induce
R10691	T13607	T13610	causeOf	T-bet,regulating
R10692	T13608	T13609	causeOf	Eomes,regulating
R10693	T13611	T13614	themeOf	granzyme B,expression
R10694	T13612	T13613	themeOf	perforin,expression
R10695	T13613	T13609	themeOf	expression,regulating
R10696	T13614	T13610	themeOf	expression,regulating
R10697	T13615	T13620	causeOf	up-regulation,preceded
R10698	T13616	T13619	causeOf	up-regulation,preceded
R10699	T13617	T13615	themeOf	T-bet,up-regulation
R10700	T13618	T13616	themeOf	Eomes,up-regulation
R10701	T13621	T13620	themeOf	up-regulation,preceded
R10702	T13622	T13619	themeOf	up-regulation,preceded
R10703	T13623	T13621	themeOf	Gzmb,up-regulation
R10704	T13624	T13622	themeOf	Prf1,up-regulation
R10705	T13625	T13626	causeOf	T-bet,had no role
R10706	T13627	T13628	themeOf	perforin,expression
R10707	T13628	T13626	themeOf	expression,had no role
R10708	T13629	T13630	causeOf	Eo-VP16,affect
R10709	T13629	T13633	themeOf	Eo-VP16,expressed
R10710	T13631	T13632	themeOf	granzyme B,expression
R10711	T13632	T13630	themeOf	expression,affect
R10712	T13636	T13637	themeOf	Eomes,deficient
R10713	T13639	T13638	themeOf	Eomes,deficient
R10714	T13641	T13642	themeOf	Eomes,deficient
R10715	T13644	T13647	causeOf	Eomes,induce
R10716	T13645	T13646	causeOf	Runx3,induce
R10717	T13648	T13649	themeOf	perforin,expression
R10718	T13649	T13647	themeOf	expression,induce
R10719	T13649	T13646	themeOf	expression,induce
R10720	T13653	T13651	themeOf	T-bet,induced
R10721	T13654	T13652	themeOf	Eomes,induced
R10722	T13660	T13659	themeOf	T-bet,interaction
R10723	T13660	T13659	causeOf	T-bet,interaction
R10724	T13660	T13657	themeOf	T-bet,interaction
R10725	T13660	T13656	causeOf	T-bet,interaction
R10726	T13661	T13657	causeOf	Runx3,interaction
R10727	T13661	T13656	themeOf	Runx3,interaction
R10728	T13661	T13658	themeOf	Runx3,interaction
R10729	T13661	T13658	causeOf	Runx3,interaction
R10730	T13663	T13664	themeOf	T-bet,induced
R10731	T13663	T13666	causeOf	T-bet,induces
R10732	T13665	T13664	causeOf	IFN-γ,induced
R10733	T13667	T13666	themeOf	Runx3,induces
R10734	T13669	T13670	causeOf	Runx3,required
R10735	T13671	T13670	themeOf	induce,required
R10736	T13672	T13671	themeOf	Eomes,induce
R10659	T13567	T13568	themeOf	Eomes,expression
R10660	T13568	T13566	themeOf	expression,induction
R10661	T13569	T13572	themeOf	T-bet,up-regulated
R10662	T13570	T13571	themeOf	Eomes,up-regulated
R10663	T13574	T13575	causeOf	T-bet,needed
R10664	T13577	T13575	themeOf	produce,needed
R10665	T13578	T13577	themeOf	IFN-γ,produce
R10666	T13579	T13580	themeOf	Eomes,induced
R10667	T13579	T13581	themeOf	Eomes,functions downstream
R10668	T13579	T13584	causeOf	Eomes,promoting
R10669	T13582	T13581	causeOf	Runx3,functions downstream
R10670	T13583	T13585	causeOf	T-bet,promoting
R10671	T13586	T13584	themeOf	expression,promoting
R10672	T13586	T13585	themeOf	expression,promoting
R10673	T13587	T13586	themeOf	IFN-γ,expression
R10674	T13588	T13591	causeOf	T-bet,contribute
R10675	T13589	T13590	causeOf	Eomes,contribute
R10676	T13592	T13593	themeOf	perforin,expression
R10677	T13593	T13591	themeOf	expression,contribute
R10678	T13593	T13590	themeOf	expression,contribute
R10681	T13597	T13596	themeOf	granzyme B,induces

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T13673	0-5	Protein	denotes	Runx3
T13674	154-159	Protein	denotes	Runx3
T13675	286-291	Protein	denotes	Runx3
T13676	312-316	Protein	denotes	CD8+
T13677	295-302	Gene_expression	denotes	present
T13678	362-367	Protein	denotes	Runx1
T13679	412-417	Protein	denotes	Eomes
T13680	419-429	Protein	denotes	granzyme B
T13681	431-439	Protein	denotes	perforin
T13682	445-450	Protein	denotes	IFN-γ
T13683	352-361	Negative_regulation	denotes	represses
T13684	399-408	Positive_regulation	denotes	induction
T13685	399-408	Positive_regulation	denotes	induction
T13686	399-408	Positive_regulation	denotes	induction
T13687	399-408	Positive_regulation	denotes	induction
T13688	452-457	Protein	denotes	Runx3
T13689	467-476	Entity	denotes	promoters
T13690	458-463	Binding	denotes	binds
T13691	648-653	Protein	denotes	Runx1
T13692	686-691	Protein	denotes	Runx3
T13693	707-712	Protein	denotes	Runx3
T13694	754-757	Protein	denotes	TNF
T13695	759-763	Protein	denotes	IL-2
T13696	769-774	Protein	denotes	IFN-γ
T13697	740-750	Gene_expression	denotes	expression
T13698	740-750	Gene_expression	denotes	expression
T13699	740-750	Gene_expression	denotes	expression
T13700	713-724	Positive_regulation	denotes	contributed
T13701	713-724	Positive_regulation	denotes	contributed
T13702	713-724	Positive_regulation	denotes	contributed
T13703	799-802	Protein	denotes	TNF
T13704	807-811	Protein	denotes	IL-2
T13705	833-838	Protein	denotes	Runx3
T13706	905-910	Protein	denotes	Runx1
T13707	936-941	Protein	denotes	Runx3
T13708	839-847	Negative_regulation	denotes	subsides
T13709	921-932	Negative_regulation	denotes	derepressed
T13710	963-968	Protein	denotes	Runx3
T13711	998-1003	Protein	denotes	IFN-γ
T13712	1004-1014	Gene_expression	denotes	expression
T13713	985-993	Positive_regulation	denotes	required
T13714	1241-1245	Protein	denotes	CD8+
T13715	1422-1426	Protein	denotes	CD8+
T13716	1461-1466	Protein	denotes	IFN-γ
T13717	1453-1460	Gene_expression	denotes	produce
T13718	1386-1392	Positive_regulation	denotes	needed
T13719	1595-1600	Protein	denotes	Runx3
T13720	1664-1669	Protein	denotes	IFN-γ
T13721	1650-1660	Gene_expression	denotes	expression
T13722	1630-1639	Positive_regulation	denotes	promoting
T13723	1739-1747	Protein	denotes	perforin
T13724	1798-1808	Protein	denotes	granzyme B
T13725	1896-1923	Protein	denotes	T-box transcription factors
T13726	1748-1758	Gene_expression	denotes	expression
T13727	1790-1797	Positive_regulation	denotes	induces
T13728	1725-1735	Positive_regulation	denotes	contribute
T13729	2076-2080	Protein	denotes	Prf1
T13730	2085-2089	Protein	denotes	Gzmb
T13731	2091-2094	Protein	denotes	Fig
T13732	2034-2040	Positive_regulation	denotes	induce
T13733	2034-2040	Positive_regulation	denotes	induce
T13734	2034-2040	Positive_regulation	denotes	induce
T13735	2231-2241	Protein	denotes	Eomes mRNA
T13736	2288-2292	Protein	denotes	Gzmb
T13737	2297-2306	Protein	denotes	Prf1 mRNA
T13738	2204-2217	Positive_regulation	denotes	up-regulation
T13739	2271-2284	Positive_regulation	denotes	up-regulation
T13740	2271-2284	Positive_regulation	denotes	up-regulation
T13741	2355-2363	Protein	denotes	perforin
T13742	2409-2416	Protein	denotes	Eo-VP16
T13743	2432-2442	Protein	denotes	granzyme B
T13744	2484-2489	Protein	denotes	Runx3
T13745	2364-2374	Gene_expression	denotes	expression
T13746	2443-2453	Gene_expression	denotes	expression
T13747	2347-2351	Regulation	denotes	role
T13748	2425-2431	Regulation	denotes	affect
T13749	2736-2741	Protein	denotes	Runx3
T13750	2763-2766	Protein	denotes	CD8
T13751	2823-2828	Protein	denotes	Runx3
T13752	2839-2847	Protein	denotes	perforin
T13753	2848-2858	Gene_expression	denotes	expression
T13754	2832-2838	Positive_regulation	denotes	induce
T13755	2950-2955	Protein	denotes	Runx3
T13756	2984-3003	Protein	denotes	T-box factors T-bet
T13757	3008-3013	Protein	denotes	Eomes
T13758	3018-3024	Protein	denotes	IL-2Rβ
T13759	2976-2983	Positive_regulation	denotes	induced
T13760	2976-2983	Positive_regulation	denotes	induced
T13761	3164-3169	Protein	denotes	Runx3
T13762	3202-3205	Protein	denotes	CD4
T13763	3310-3313	Protein	denotes	TCR
T13764	3326-3331	Protein	denotes	IFN-γ
T13765	3392-3396	Protein	denotes	CD8+
T13766	3418-3423	Protein	denotes	Runx3
T13767	3450-3482	Protein	denotes	T-box transcription factor Eomes
T13768	3439-3445	Positive_regulation	denotes	induce
T13769	3604-3615	Protein	denotes	Runx family
R10737	T13675	T13677	themeOf	Runx3,present
R10738	T13678	T13683	themeOf	Runx1,represses
R10739	T13679	T13684	themeOf	Eomes,induction
R10740	T13680	T13685	themeOf	granzyme B,induction
R10741	T13681	T13686	themeOf	perforin,induction
R10742	T13682	T13687	themeOf	IFN-γ,induction
R10743	T13688	T13690	themeOf	Runx3,binds
R10744	T13689	T13690	Site	promoters,binds
R10745	T13693	T13700	causeOf	Runx3,contributed
R10746	T13693	T13701	causeOf	Runx3,contributed
R10747	T13693	T13702	causeOf	Runx3,contributed
R10748	T13694	T13697	themeOf	TNF,expression
R10749	T13695	T13698	themeOf	IL-2,expression
R10750	T13696	T13699	themeOf	IFN-γ,expression
R10751	T13697	T13700	themeOf	expression,contributed
R10752	T13698	T13701	themeOf	expression,contributed
R10753	T13699	T13702	themeOf	expression,contributed
R10754	T13705	T13708	themeOf	Runx3,subsides
R10755	T13706	T13709	themeOf	Runx1,derepressed
R10756	T13710	T13713	causeOf	Runx3,required
R10757	T13711	T13712	themeOf	IFN-γ,expression
R10758	T13712	T13713	themeOf	expression,required
R10759	T13716	T13717	themeOf	IFN-γ,produce
R10760	T13717	T13718	themeOf	produce,needed
R10761	T13720	T13721	themeOf	IFN-γ,expression
R10762	T13721	T13722	themeOf	expression,promoting
R10763	T13723	T13726	themeOf	perforin,expression
R10764	T13724	T13727	themeOf	granzyme B,induces
R10765	T13726	T13728	themeOf	expression,contribute
R10766	T13729	T13732	themeOf	Prf1,induce
R10767	T13730	T13733	themeOf	Gzmb,induce
R10768	T13731	T13734	themeOf	Fig,induce
R10769	T13735	T13738	themeOf	Eomes mRNA,up-regulation
R10770	T13736	T13739	themeOf	Gzmb,up-regulation
R10771	T13737	T13740	themeOf	Prf1 mRNA,up-regulation
R10772	T13741	T13745	themeOf	perforin,expression
R10773	T13742	T13748	causeOf	Eo-VP16,affect
R10774	T13743	T13746	themeOf	granzyme B,expression
R10775	T13745	T13747	themeOf	expression,role
R10776	T13746	T13748	themeOf	expression,affect
R10777	T13751	T13754	causeOf	Runx3,induce
R10778	T13752	T13753	themeOf	perforin,expression
R10779	T13753	T13754	themeOf	expression,induce
R10780	T13756	T13759	themeOf	T-box factors T-bet,induced
R10781	T13757	T13760	themeOf	Eomes,induced
R10782	T13766	T13768	causeOf	Runx3,induce
R10783	T13767	T13768	themeOf	T-box transcription factor Eomes,induce

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T11753	648-653	Protein	denotes	Runx1
T11754	670-676	Binding	denotes	target		true
T11755	670-676	Binding	denotes	target		true
T11756	686-691	Protein	denotes	Runx3
T11757	707-712	Protein	denotes	Runx3
T11758	713-724	Positive_regulation	denotes	contributed
T11759	713-724	Positive_regulation	denotes	contributed
T11760	713-724	Positive_regulation	denotes	contributed
T11761	740-750	Gene_expression	denotes	expression
T11762	740-750	Gene_expression	denotes	expression
T11763	740-750	Gene_expression	denotes	expression
T11764	754-757	Protein	denotes	TNF
T11765	759-763	Protein	denotes	IL-2
T11766	769-774	Protein	denotes	IFN-γ
T11767	799-802	Protein	denotes	TNF
T11768	807-811	Protein	denotes	IL-2
T11769	817-828	Positive_regulation	denotes	requirement
T11770	817-828	Positive_regulation	denotes	requirement
T11771	833-838	Protein	denotes	Runx3
T11772	839-847	Negative_regulation	denotes	subsides
T11773	839-847	Negative_regulation	denotes	subsides
T11774	905-910	Protein	denotes	Runx1
T11775	921-932	Negative_regulation	denotes	derepressed	true
T11776	936-941	Protein	denotes	Runx3
T11777	963-968	Protein	denotes	Runx3
T11778	985-993	Positive_regulation	denotes	required
T11779	998-1003	Protein	denotes	IFN-γ
T11780	1004-1014	Gene_expression	denotes	expression
T11781	1053-1057	Regulation	denotes	role		true
T11782	1065-1074	Positive_regulation	denotes	induction
T11783	1078-1083	Protein	denotes	Eomes
T11784	1084-1094	Gene_expression	denotes	expression
T11785	1175-1180	Protein	denotes	T-bet
T11786	1185-1190	Protein	denotes	Eomes
T11787	1196-1208	Positive_regulation	denotes	up-regulated
T11788	1196-1208	Positive_regulation	denotes	up-regulated
T11789	1241-1244	Protein	denotes	CD8
T11790	1377-1382	Protein	denotes	T-bet
T11791	1386-1392	Positive_regulation	denotes	needed
T11792	1422-1425	Protein	denotes	CD8
T11793	1453-1460	Gene_expression	denotes	produce
T11794	1461-1466	Protein	denotes	IFN-γ
T11795	1538-1543	Protein	denotes	Eomes
T11796	1554-1561	Positive_regulation	denotes	induced
T11797	1571-1591	Regulation	denotes	functions downstream
T11798	1595-1600	Protein	denotes	Runx3
T11799	1621-1626	Protein	denotes	T-bet
T11800	1630-1639	Positive_regulation	denotes	promoting		true
T11801	1630-1639	Positive_regulation	denotes	promoting		true
T11802	1650-1660	Gene_expression	denotes	expression
T11803	1664-1669	Protein	denotes	IFN-γ
T11804	1704-1709	Protein	denotes	T-bet
T11805	1714-1719	Protein	denotes	Eomes
T11806	1725-1735	Positive_regulation	denotes	contribute
T11807	1725-1735	Positive_regulation	denotes	contribute
T11808	1739-1747	Protein	denotes	perforin
T11809	1748-1758	Gene_expression	denotes	expression
T11810	1784-1789	Protein	denotes	Eomes
T11811	1790-1797	Positive_regulation	denotes	induces
T11812	1790-1797	Positive_regulation	denotes	induces
T11813	1798-1808	Protein	denotes	granzyme B
T11814	1827-1832	Protein	denotes	T-bet
T11815	1976-1981	Protein	denotes	Eomes
T11816	1986-1991	Protein	denotes	T-bet
T11817	2034-2040	Positive_regulation	denotes	induce
T11818	2034-2040	Positive_regulation	denotes	induce
T11819	2034-2040	Positive_regulation	denotes	induce
T11820	2034-2040	Positive_regulation	denotes	induce
T11821	2076-2080	Protein	denotes	Prf1
T11822	2085-2089	Protein	denotes	Gzmb
T11823	2110-2115	Protein	denotes	T-bet
T11824	2120-2125	Protein	denotes	Eomes
T11825	2143-2153	Regulation	denotes	regulating
T11826	2143-2153	Regulation	denotes	regulating
T11827	2154-2164	Protein	denotes	granzyme B
T11828	2169-2177	Protein	denotes	perforin
T11829	2178-2188	Gene_expression	denotes	expression
T11830	2178-2188	Gene_expression	denotes	expression
T11831	2204-2217	Positive_regulation	denotes	up-regulation
T11832	2204-2217	Positive_regulation	denotes	up-regulation
T11833	2221-2226	Protein	denotes	T-bet
T11834	2231-2236	Protein	denotes	Eomes
T11835	2262-2270	Positive_regulation	denotes	preceded
T11836	2262-2270	Positive_regulation	denotes	preceded
T11837	2271-2284	Positive_regulation	denotes	up-regulation
T11838	2271-2284	Positive_regulation	denotes	up-regulation
T11839	2288-2292	Protein	denotes	Gzmb
T11840	2297-2301	Protein	denotes	Prf1
T11841	2334-2339	Protein	denotes	T-bet
T11842	2340-2351	Regulation	denotes	had no role
T11843	2355-2363	Protein	denotes	perforin
T11844	2364-2374	Gene_expression	denotes	expression
T11845	2409-2416	Protein	denotes	Eo-VP16
T11846	2425-2431	Regulation	denotes	affect	true
T11847	2432-2442	Protein	denotes	granzyme B
T11848	2443-2453	Gene_expression	denotes	expression
T11849	2459-2468	Gene_expression	denotes	expressed
T11850	2472-2477	Protein	denotes	T-bet
T11851	2484-2489	Protein	denotes	Runx3
T11877	3164-3169	Protein	denotes	Runx3
T11878	3202-3205	Protein	denotes	CD4
T11879	3290-3295	Protein	denotes	T-bet
T11880	3299-3306	Positive_regulation	denotes	induced
T11881	3326-3331	Protein	denotes	IFN-γ
T11882	3345-3352	Positive_regulation	denotes	induces
T11883	3353-3358	Protein	denotes	Runx3
T11884	3392-3395	Protein	denotes	CD8
T11885	3418-3423	Protein	denotes	Runx3
T11886	3427-3435	Positive_regulation	denotes	required
T11887	3439-3445	Positive_regulation	denotes	induce
T11888	3477-3482	Protein	denotes	Eomes
T11718	0-5	Protein	denotes	Runx3
T11719	154-159	Protein	denotes	Runx3
T11720	286-291	Protein	denotes	Runx3
T11721	295-302	Gene_expression	denotes	present
T11722	312-315	Protein	denotes	CD8
T11723	352-361	Negative_regulation	denotes	represses
T11724	362-367	Protein	denotes	Runx1
T11725	372-391	Positive_regulation	denotes	has a positive role
T11726	372-391	Positive_regulation	denotes	has a positive role
T11727	372-391	Positive_regulation	denotes	has a positive role
T11728	372-391	Positive_regulation	denotes	has a positive role
T11729	399-408	Positive_regulation	denotes	induction
T11730	399-408	Positive_regulation	denotes	induction
T11731	399-408	Positive_regulation	denotes	induction
T11732	399-408	Positive_regulation	denotes	induction
T11733	412-417	Protein	denotes	Eomes
T11734	419-429	Protein	denotes	granzyme B
T11735	431-439	Protein	denotes	perforin
T11736	445-450	Protein	denotes	IFN-γ
T11737	452-457	Protein	denotes	Runx3
T11738	458-463	Binding	denotes	binds
T11739	458-463	Binding	denotes	binds
T11740	458-463	Binding	denotes	binds
T11741	458-463	Binding	denotes	binds
T11742	458-463	Binding	denotes	binds
T11743	458-463	Binding	denotes	binds
T11744	467-476	Entity	denotes	promoters
T11745	490-508	Entity	denotes	regulatory regions
T11746	556-562	Regulation	denotes	effect		true
T11747	556-562	Regulation	denotes	effect		true
T11748	556-562	Regulation	denotes	effect		true
T11749	571-581	Gene_expression	denotes	expression
T11750	571-581	Gene_expression	denotes	expression
T11751	571-581	Gene_expression	denotes	expression
T11752	638-643	Protein	denotes	Eomes
T11852	2521-2526	Protein	denotes	Eomes
T11853	2527-2536	Negative_regulation	denotes	deficient
T11854	2650-2659	Negative_regulation	denotes	deficient
T11855	2663-2668	Protein	denotes	Eomes
T11856	2736-2741	Protein	denotes	Runx3
T11857	2747-2752	Protein	denotes	Eomes
T11858	2753-2762	Negative_regulation	denotes	deficient
T11859	2763-2766	Protein	denotes	CD8
T11860	2801-2806	Protein	denotes	Eomes
T11861	2823-2828	Protein	denotes	Runx3
T11862	2832-2838	Positive_regulation	denotes	induce		true
T11863	2832-2838	Positive_regulation	denotes	induce		true
T11864	2839-2847	Protein	denotes	perforin
T11865	2848-2858	Gene_expression	denotes	expression
T11866	2950-2955	Protein	denotes	Runx3
T11867	2976-2983	Positive_regulation	denotes	induced
T11868	2976-2983	Positive_regulation	denotes	induced
T11869	2998-3003	Protein	denotes	T-bet
T11870	3008-3013	Protein	denotes	Eomes
T11871	3018-3024	Protein	denotes	IL-2Rβ
T11872	3134-3145	Regulation	denotes	interaction
T11873	3134-3145	Regulation	denotes	interaction
T11874	3134-3145	Regulation	denotes	interaction
T11875	3134-3145	Regulation	denotes	interaction
T11876	3154-3159	Protein	denotes	T-bet
R9162	T11720	T11728	causeOf	Runx3,has a positive role
R9163	T11720	T11725	causeOf	Runx3,has a positive role
R9164	T11720	T11726	causeOf	Runx3,has a positive role
R9166	T11729	T11728	themeOf	induction,has a positive role
R9167	T11730	T11726	themeOf	induction,has a positive role
R9168	T11731	T11725	themeOf	induction,has a positive role
R9170	T11733	T11732	themeOf	Eomes,induction
R9171	T11734	T11729	themeOf	granzyme B,induction
R9172	T11734	T11751	themeOf	granzyme B,expression
R9173	T11735	T11731	themeOf	perforin,induction
R9174	T11735	T11749	themeOf	perforin,expression
R9175	T11736	T11730	themeOf	IFN-γ,induction
R9176	T11736	T11750	themeOf	IFN-γ,expression
R9177	T11737	T11738	themeOf	Runx3,binds
R9178	T11737	T11740	themeOf	Runx3,binds
R9179	T11737	T11741	themeOf	Runx3,binds
R9180	T11737	T11743	themeOf	Runx3,binds
R9181	T11737	T11742	themeOf	Runx3,binds
R9182	T11737	T11739	themeOf	Runx3,binds
R9183	T11737	T11747	causeOf	Runx3,effect
R9184	T11737	T11746	causeOf	Runx3,effect
R9185	T11737	T11748	causeOf	Runx3,effect
R9186	T11744	T11738	themeOf	promoters,binds
R9187	T11744	T11734	partOf	promoters,granzyme B
R9188	T11744	T11740	themeOf	promoters,binds
R9189	T11744	T11735	partOf	promoters,perforin
R9190	T11744	T11741	themeOf	promoters,binds
R9191	T11744	T11736	partOf	promoters,IFN-γ
R9192	T11745	T11743	themeOf	regulatory regions,binds
R9193	T11745	T11734	partOf	regulatory regions,granzyme B
R9194	T11745	T11742	themeOf	regulatory regions,binds
R9195	T11745	T11735	partOf	regulatory regions,perforin
R9196	T11745	T11739	themeOf	regulatory regions,binds
R9197	T11745	T11736	partOf	regulatory regions,IFN-γ
R9198	T11749	T11746	themeOf	expression,effect
R9199	T11750	T11748	themeOf	expression,effect
R9200	T11751	T11747	themeOf	expression,effect
R9201	T11752	T11755	themeOf	Eomes,target
R9202	T11753	T11754	themeOf	Runx1,target
R9203	T11756	T11755	themeOf	Runx3,target
R9204	T11756	T11754	themeOf	Runx3,target
R9205	T11757	T11758	causeOf	Runx3,contributed
R9206	T11757	T11760	causeOf	Runx3,contributed
R9207	T11757	T11759	causeOf	Runx3,contributed
R9208	T11761	T11759	themeOf	expression,contributed
R9209	T11762	T11760	themeOf	expression,contributed
R9210	T11763	T11758	themeOf	expression,contributed
R9211	T11764	T11763	themeOf	TNF,expression
R9212	T11765	T11762	themeOf	IL-2,expression
R9213	T11766	T11761	themeOf	IFN-γ,expression
R9214	T11767	T11770	themeOf	TNF,requirement
R9215	T11768	T11769	themeOf	IL-2,requirement
R9216	T11769	T11773	themeOf	requirement,subsides
R9217	T11770	T11772	themeOf	requirement,subsides
R9218	T11771	T11770	causeOf	Runx3,requirement
R9219	T11771	T11769	causeOf	Runx3,requirement
R9220	T11774	T11772	causeOf	Runx1,subsides
R9221	T11774	T11773	causeOf	Runx1,subsides
R9222	T11774	T11775	themeOf	Runx1,derepressed
R9223	T11777	T11778	causeOf	Runx3,required
R9224	T11777	T11781	causeOf	Runx3,role
R9225	T11779	T11780	themeOf	IFN-γ,expression
R9226	T11780	T11778	themeOf	expression,required
R9227	T11782	T11781	themeOf	induction,role
R9228	T11783	T11784	themeOf	Eomes,expression
R9229	T11784	T11782	themeOf	expression,induction
R9230	T11785	T11788	themeOf	T-bet,up-regulated
R9231	T11786	T11787	themeOf	Eomes,up-regulated
R9233	T11793	T11791	themeOf	produce,needed
R9274	T11841	T11842	causeOf	T-bet,had no role
R9275	T11843	T11844	themeOf	perforin,expression
R9276	T11844	T11842	themeOf	expression,had no role
R9277	T11845	T11846	causeOf	Eo-VP16,affect
R9278	T11845	T11849	themeOf	Eo-VP16,expressed
R9279	T11847	T11848	themeOf	granzyme B,expression
R9280	T11848	T11846	themeOf	expression,affect
R9281	T11852	T11853	themeOf	Eomes,deficient
R9282	T11855	T11854	themeOf	Eomes,deficient
R9283	T11857	T11858	themeOf	Eomes,deficient
R9284	T11860	T11863	causeOf	Eomes,induce
R9285	T11861	T11862	causeOf	Runx3,induce
R9286	T11864	T11865	themeOf	perforin,expression
R9287	T11865	T11863	themeOf	expression,induce
R9288	T11865	T11862	themeOf	expression,induce
R9289	T11869	T11867	themeOf	T-bet,induced
R9290	T11870	T11868	themeOf	Eomes,induced
R9291	T11876	T11875	themeOf	T-bet,interaction
R9292	T11876	T11875	causeOf	T-bet,interaction
R9293	T11876	T11873	themeOf	T-bet,interaction
R9294	T11876	T11872	causeOf	T-bet,interaction
R9295	T11877	T11873	causeOf	Runx3,interaction
R9296	T11877	T11872	themeOf	Runx3,interaction
R9297	T11877	T11874	themeOf	Runx3,interaction
R9298	T11877	T11874	causeOf	Runx3,interaction
R9299	T11879	T11880	themeOf	T-bet,induced
R9300	T11879	T11882	causeOf	T-bet,induces
R9301	T11881	T11880	causeOf	IFN-γ,induced
R9302	T11883	T11882	themeOf	Runx3,induces
R9303	T11885	T11886	causeOf	Runx3,required
R9304	T11887	T11886	themeOf	induce,required
R9305	T11888	T11887	themeOf	Eomes,induce
R9159	T11720	T11721	themeOf	Runx3,present
R9160	T11720	T11723	causeOf	Runx3,represses
R9161	T11720	T11727	causeOf	Runx3,has a positive role
R9165	T11724	T11723	themeOf	Runx1,represses
R9169	T11732	T11727	themeOf	induction,has a positive role
R9248	T11810	T11812	causeOf	Eomes,induces
R9249	T11813	T11811	themeOf	granzyme B,induces
R9251	T11814	T11811	causeOf	T-bet,induces
R9252	T11815	T11820	causeOf	Eomes,induce
R9253	T11815	T11817	causeOf	Eomes,induce
R9254	T11816	T11818	causeOf	T-bet,induce
R9255	T11816	T11819	causeOf	T-bet,induce
R9256	T11821	T11820	themeOf	Prf1,induce
R9257	T11821	T11818	themeOf	Prf1,induce
R9258	T11822	T11817	themeOf	Gzmb,induce
R9259	T11822	T11819	themeOf	Gzmb,induce
R9260	T11823	T11826	causeOf	T-bet,regulating
R9261	T11824	T11825	causeOf	Eomes,regulating
R9262	T11827	T11830	themeOf	granzyme B,expression
R9263	T11828	T11829	themeOf	perforin,expression
R9264	T11829	T11825	themeOf	expression,regulating
R9265	T11830	T11826	themeOf	expression,regulating
R9266	T11831	T11836	causeOf	up-regulation,preceded
R9267	T11832	T11835	causeOf	up-regulation,preceded
R9268	T11833	T11831	themeOf	T-bet,up-regulation
R9269	T11834	T11832	themeOf	Eomes,up-regulation
R9270	T11837	T11836	themeOf	up-regulation,preceded
R9271	T11838	T11835	themeOf	up-regulation,preceded
R9272	T11839	T11837	themeOf	Gzmb,up-regulation
R9273	T11840	T11838	themeOf	Prf1,up-regulation
R9232	T11790	T11791	causeOf	T-bet,needed
R9234	T11794	T11793	themeOf	IFN-γ,produce
R9235	T11795	T11796	themeOf	Eomes,induced
R9236	T11795	T11797	themeOf	Eomes,functions downstream
R9237	T11795	T11800	causeOf	Eomes,promoting
R9238	T11798	T11797	causeOf	Runx3,functions downstream
R9239	T11799	T11801	causeOf	T-bet,promoting
R9240	T11802	T11800	themeOf	expression,promoting
R9241	T11802	T11801	themeOf	expression,promoting
R9242	T11803	T11802	themeOf	IFN-γ,expression
R9243	T11804	T11807	causeOf	T-bet,contribute
R9244	T11805	T11806	causeOf	Eomes,contribute
R9245	T11808	T11809	themeOf	perforin,expression
R9246	T11809	T11807	themeOf	expression,contribute
R9247	T11809	T11806	themeOf	expression,contribute
R9250	T11813	T11812	themeOf	granzyme B,induces

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T12608	0-5	Q13761	denotes	Runx3
T12609	154-159	Q13761	denotes	Runx3
T12610	286-291	Q13761	denotes	Runx3
T12611	312-315	P10966	denotes	CD8
T12612	312-315	P01732	denotes	CD8
T12613	362-367	Q01196	denotes	Runx1
T12614	412-417	O95936	denotes	Eomes
T12615	419-429	P10144	denotes	granzyme B
T12616	431-439	P14222	denotes	perforin
T12617	445-450	P01579	denotes	IFN-γ
T12618	452-457	Q13761	denotes	Runx3
T12619	638-643	O95936	denotes	Eomes
T12620	648-653	Q01196	denotes	Runx1
T12621	686-691	Q13761	denotes	Runx3
T12622	707-712	Q13761	denotes	Runx3
T12623	754-757	P01375	denotes	TNF
T12624	759-763	P60568	denotes	IL-2
T12625	769-774	P01579	denotes	IFN-γ
T12626	799-802	P01375	denotes	TNF
T12627	807-811	P60568	denotes	IL-2
T12628	833-838	Q13761	denotes	Runx3
T12629	905-910	Q01196	denotes	Runx1
T12630	936-941	Q13761	denotes	Runx3
T12631	963-968	Q13761	denotes	Runx3
T12632	998-1003	P01579	denotes	IFN-γ
T12633	1078-1083	O95936	denotes	Eomes
T12634	1175-1180	Q9UL17	denotes	T-bet
T12635	1185-1190	O95936	denotes	Eomes
T12636	1241-1244	P10966	denotes	CD8
T12637	1241-1244	P01732	denotes	CD8
T12638	1377-1382	Q9UL17	denotes	T-bet
T12639	1422-1425	P10966	denotes	CD8
T12640	1422-1425	P01732	denotes	CD8
T12641	1461-1466	P01579	denotes	IFN-γ
T12642	1538-1543	O95936	denotes	Eomes
T12643	1595-1600	Q13761	denotes	Runx3
T12644	1621-1626	Q9UL17	denotes	T-bet
T12645	1664-1669	P01579	denotes	IFN-γ
T12646	1704-1709	Q9UL17	denotes	T-bet
T12647	1714-1719	O95936	denotes	Eomes
T12648	1739-1747	P14222	denotes	perforin
T12649	1784-1789	O95936	denotes	Eomes
T12650	1798-1808	P10144	denotes	granzyme B
T12651	1827-1832	Q9UL17	denotes	T-bet
T12652	1872-1880	Q04864	denotes	relative
T12653	1976-1981	O95936	denotes	Eomes
T12654	1986-1991	Q9UL17	denotes	T-bet
T12655	2076-2080	P14222	denotes	Prf1
T12656	2085-2089	P10144	denotes	Gzmb
T12657	2110-2115	Q9UL17	denotes	T-bet
T12658	2120-2125	O95936	denotes	Eomes
T12659	2154-2164	P10144	denotes	granzyme B
T12660	2169-2177	P14222	denotes	perforin
T12661	2221-2226	Q9UL17	denotes	T-bet
T12662	2231-2236	O95936	denotes	Eomes
T12663	2288-2292	P10144	denotes	Gzmb
T12664	2297-2301	P14222	denotes	Prf1
T12665	2334-2339	Q9UL17	denotes	T-bet
T12666	2355-2363	P14222	denotes	perforin
T12667	2409-2416	O95936	denotes	Eo-VP16
T12668	2432-2442	P10144	denotes	granzyme B
T12669	2472-2477	Q9UL17	denotes	T-bet
T12670	2484-2489	Q13761	denotes	Runx3
T12671	2521-2526	O95936	denotes	Eomes
T12672	2663-2668	O95936	denotes	Eomes
T12673	2736-2741	Q13761	denotes	Runx3
T12674	2747-2752	O95936	denotes	Eomes
T12675	2763-2766	P10966	denotes	CD8
T12676	2763-2766	P01732	denotes	CD8
T12677	2801-2806	O95936	denotes	Eomes
T12678	2823-2828	Q13761	denotes	Runx3
T12679	2839-2847	P14222	denotes	perforin
T12680	2950-2955	Q13761	denotes	Runx3
T12681	2998-3003	Q9UL17	denotes	T-bet
T12682	3008-3013	O95936	denotes	Eomes
T12683	3154-3159	Q9UL17	denotes	T-bet
T12684	3164-3169	Q13761	denotes	Runx3
T12685	3202-3205	P01730	denotes	CD4
T12686	3290-3295	Q9UL17	denotes	T-bet
T12687	3326-3331	P01579	denotes	IFN-γ
T12688	3353-3358	Q13761	denotes	Runx3
T12689	3392-3395	P01732	denotes	CD8
T12690	3392-3395	P10966	denotes	CD8
T12691	3418-3423	Q13761	denotes	Runx3
T12692	3477-3482	O95936	denotes	Eomes
T12693	3604-3608	Q01196	denotes	Runx
T12694	3604-3608	Q13950	denotes	Runx
T12695	3604-3608	Q13761	denotes	Runx

test2

Id	Subject	Object	Predicate	Lexical cue	Negation	Speculation
T11595	0-5	Protein	denotes	Runx3
T11596	154-159	Protein	denotes	Runx3
T11597	286-291	Protein	denotes	Runx3
T11598	312-315	Protein	denotes	CD8
T11599	352-361	Negative_regulation	denotes	represses
T11600	362-367	Protein	denotes	Runx1
T11601	372-391	Positive_regulation	denotes	has a positive role
T11602	399-408	Positive_regulation	denotes	induction
T11603	412-417	Protein	denotes	Eomes
T11604	419-429	Protein	denotes	granzyme B
T11605	431-439	Protein	denotes	perforin
T11606	445-450	Protein	denotes	IFN-γ
T11607	452-457	Protein	denotes	Runx3
T11608	458-463	Binding	denotes	binds
T11609	467-476	Entity	denotes	promoters
T11610	490-508	Entity	denotes	regulatory regions
T11611	638-643	Protein	denotes	Eomes		true
T11612	648-653	Protein	denotes	Runx1
T11613	686-691	Protein	denotes	Runx3		true
T11614	707-712	Protein	denotes	Runx3
T11615	713-724	Positive_regulation	denotes	contributed		true
T11616	740-750	Gene_expression	denotes	expression
T11617	754-757	Protein	denotes	TNF		true
T11618	759-763	Protein	denotes	IL-2		true
T11619	769-774	Protein	denotes	IFN-γ
T11620	799-802	Protein	denotes	TNF
T11621	807-811	Protein	denotes	IL-2
T11622	833-838	Protein	denotes	Runx3
T11623	905-910	Protein	denotes	Runx1
T11624	936-941	Protein	denotes	Runx3
T11625	963-968	Protein	denotes	Runx3
T11626	985-993	Positive_regulation	denotes	required
T11627	998-1003	Protein	denotes	IFN-γ
T11628	1004-1014	Gene_expression	denotes	expression
T11629	1053-1057	Regulation	denotes	role	true
T11630	1065-1074	Positive_regulation	denotes	induction
T11631	1078-1083	Protein	denotes	Eomes
T11632	1084-1094	Gene_expression	denotes	expression		true
T11633	1175-1180	Protein	denotes	T-bet
T11634	1185-1190	Protein	denotes	Eomes
T11635	1196-1208	Positive_regulation	denotes	up-regulated
T11636	1241-1244	Protein	denotes	CD8
T11637	1377-1382	Protein	denotes	T-bet
T11638	1422-1425	Protein	denotes	CD8
T11639	1453-1460	Gene_expression	denotes	produce
T11640	1461-1466	Protein	denotes	IFN-γ
T11641	1538-1543	Protein	denotes	Eomes		true
T11642	1554-1561	Positive_regulation	denotes	induced
T11643	1581-1591	Regulation	denotes	downstream		true
T11644	1595-1600	Protein	denotes	Runx3
T11645	1621-1626	Protein	denotes	T-bet
T11646	1630-1639	Positive_regulation	denotes	promoting
T11647	1650-1660	Gene_expression	denotes	expression
T11648	1664-1669	Protein	denotes	IFN-γ
T11649	1704-1709	Protein	denotes	T-bet
T11650	1714-1719	Protein	denotes	Eomes
T11651	1725-1735	Positive_regulation	denotes	contribute
T11652	1739-1747	Protein	denotes	perforin
T11653	1748-1758	Gene_expression	denotes	expression
T11654	1784-1789	Protein	denotes	Eomes
T11655	1790-1797	Positive_regulation	denotes	induces
T11656	1798-1808	Protein	denotes	granzyme B
T11657	1827-1832	Protein	denotes	T-bet
T11658	1976-1981	Protein	denotes	Eomes
T11659	1986-1991	Protein	denotes	T-bet
T11660	2034-2040	Positive_regulation	denotes	induce
T11661	2076-2080	Protein	denotes	Prf1
T11662	2085-2089	Protein	denotes	Gzmb
T11663	2110-2115	Protein	denotes	T-bet
T11664	2120-2125	Protein	denotes	Eomes
T11665	2143-2153	Regulation	denotes	regulating	true
T11666	2154-2164	Protein	denotes	granzyme B
T11667	2169-2177	Protein	denotes	perforin
T11668	2178-2188	Gene_expression	denotes	expression
T11669	2204-2217	Positive_regulation	denotes	up-regulation
T11670	2221-2226	Protein	denotes	T-bet
T11671	2231-2236	Protein	denotes	Eomes		true
T11672	2271-2284	Positive_regulation	denotes	up-regulation
T11673	2288-2292	Protein	denotes	Gzmb		true
T11674	2297-2301	Protein	denotes	Prf1
T11675	2334-2339	Protein	denotes	T-bet
T11676	2347-2351	Regulation	denotes	role
T11677	2355-2363	Protein	denotes	perforin
T11678	2364-2374	Gene_expression	denotes	expression
T11679	2409-2416	Protein	denotes	Eo-VP16
T11680	2425-2431	Regulation	denotes	affect
T11681	2432-2442	Protein	denotes	granzyme B
T11682	2443-2453	Gene_expression	denotes	expression
T11683	2459-2468	Gene_expression	denotes	expressed
T11684	2472-2477	Protein	denotes	T-bet
T11685	2484-2489	Protein	denotes	Runx3
T11686	2521-2526	Protein	denotes	Eomes
T11687	2527-2536	Negative_regulation	denotes	deficient
T11688	2650-2659	Negative_regulation	denotes	deficient
T11689	2663-2668	Protein	denotes	Eomes
T11690	2736-2741	Protein	denotes	Runx3
T11691	2747-2752	Protein	denotes	Eomes
T11692	2753-2762	Negative_regulation	denotes	deficient
T11693	2763-2766	Protein	denotes	CD8
T11694	2801-2806	Protein	denotes	Eomes
T11695	2823-2828	Protein	denotes	Runx3
T11696	2832-2838	Positive_regulation	denotes	induce
T11697	2839-2847	Protein	denotes	perforin
T11698	2848-2858	Gene_expression	denotes	expression
T11699	2950-2955	Protein	denotes	Runx3
T11700	2976-2983	Positive_regulation	denotes	induced
T11701	2998-3003	Protein	denotes	T-bet
T11702	3008-3013	Protein	denotes	Eomes
T11703	3018-3024	Protein	denotes	IL-2Rβ
T11704	3134-3145	Binding	denotes	interaction
T11705	3154-3159	Protein	denotes	T-bet
T11706	3164-3169	Protein	denotes	Runx3
T11707	3202-3205	Protein	denotes	CD4
T11708	3290-3295	Protein	denotes	T-bet
T11709	3299-3306	Positive_regulation	denotes	induced
T11710	3326-3331	Protein	denotes	IFN-γ
T11711	3345-3352	Positive_regulation	denotes	induces
T11712	3353-3358	Protein	denotes	Runx3
T11713	3392-3395	Protein	denotes	CD8
T11714	3418-3423	Protein	denotes	Runx3
T11715	3427-3435	Positive_regulation	denotes	required
T11716	3439-3445	Positive_regulation	denotes	induce
T11717	3477-3482	Protein	denotes	Eomes
R9084	T11600	T11599	themeOf	Runx1,represses
R9085	T11600	T11601	causeOf	Runx1,has a positive role
R9086	T11602	T11601	themeOf	induction,has a positive role
R9087	T11603	T11602	themeOf	Eomes,induction
R9088	T11604	T11602	themeOf	granzyme B,induction
R9089	T11605	T11602	themeOf	perforin,induction
R9090	T11606	T11602	themeOf	IFN-γ,induction
R9091	T11607	T11608	themeOf	Runx3,binds
R9092	T11609	T11608	themeOf	promoters,binds
R9093	T11610	T11608	themeOf	regulatory regions,binds
R9094	T11614	T11615	causeOf	Runx3,contributed
R9095	T11616	T11615	themeOf	expression,contributed
R9096	T11617	T11616	themeOf	TNF,expression
R9097	T11618	T11616	themeOf	IL-2,expression
R9098	T11619	T11616	themeOf	IFN-γ,expression
R9099	T11625	T11626	causeOf	Runx3,required
R9100	T11625	T11629	causeOf	Runx3,role
R9101	T11627	T11628	themeOf	IFN-γ,expression
R9102	T11628	T11626	themeOf	expression,required
R9103	T11631	T11632	themeOf	Eomes,expression
R9104	T11632	T11630	themeOf	expression,induction
R9105	T11633	T11635	themeOf	T-bet,up-regulated
R9106	T11634	T11635	themeOf	Eomes,up-regulated
R9107	T11640	T11639	themeOf	IFN-γ,produce
R9108	T11641	T11642	themeOf	Eomes,induced
R9109	T11641	T11646	causeOf	Eomes,promoting
R9110	T11645	T11646	causeOf	T-bet,promoting
R9111	T11647	T11646	themeOf	expression,promoting
R9112	T11648	T11647	themeOf	IFN-γ,expression
R9113	T11649	T11651	causeOf	T-bet,contribute
R9114	T11650	T11651	causeOf	Eomes,contribute
R9115	T11652	T11653	themeOf	perforin,expression
R9116	T11653	T11651	themeOf	expression,contribute
R9117	T11654	T11655	causeOf	Eomes,induces
R9118	T11656	T11655	themeOf	granzyme B,induces
R9119	T11658	T11660	causeOf	Eomes,induce
R9120	T11659	T11660	causeOf	T-bet,induce
R9121	T11661	T11660	themeOf	Prf1,induce
R9122	T11662	T11660	themeOf	Gzmb,induce
R9123	T11663	T11665	causeOf	T-bet,regulating
R9124	T11664	T11665	causeOf	Eomes,regulating
R9125	T11666	T11668	themeOf	granzyme B,expression
R9126	T11667	T11668	themeOf	perforin,expression
R9127	T11668	T11665	themeOf	expression,regulating
R9128	T11670	T11669	themeOf	T-bet,up-regulation
R9129	T11671	T11669	themeOf	Eomes,up-regulation
R9130	T11673	T11672	themeOf	Gzmb,up-regulation
R9131	T11674	T11672	themeOf	Prf1,up-regulation
R9132	T11675	T11683	themeOf	T-bet,expressed
R9133	T11675	T11676	causeOf	T-bet,role
R9134	T11677	T11678	themeOf	perforin,expression
R9136	T11679	T11683	themeOf	Eo-VP16,expressed
R9137	T11679	T11680	causeOf	Eo-VP16,affect
R9138	T11681	T11682	themeOf	granzyme B,expression
R9139	T11682	T11680	themeOf	expression,affect
R9135	T11678	T11676	themeOf	expression,role
R9140	T11686	T11687	themeOf	Eomes,deficient
R9141	T11689	T11688	themeOf	Eomes,deficient
R9142	T11691	T11692	themeOf	Eomes,deficient
R9143	T11694	T11696	causeOf	Eomes,induce
R9144	T11695	T11696	causeOf	Runx3,induce
R9145	T11697	T11698	themeOf	perforin,expression
R9146	T11698	T11696	themeOf	expression,induce
R9147	T11701	T11700	themeOf	T-bet,induced
R9148	T11702	T11700	themeOf	Eomes,induced
R9149	T11703	T11700	themeOf	IL-2Rβ,induced
R9150	T11705	T11704	causeOf	T-bet,interaction
R9151	T11706	T11704	causeOf	Runx3,interaction
R9152	T11708	T11709	themeOf	T-bet,induced
R9153	T11708	T11711	causeOf	T-bet,induces
R9154	T11710	T11709	causeOf	IFN-γ,induced
R9155	T11712	T11711	themeOf	Runx3,induces
R9156	T11714	T11715	causeOf	Runx3,required
R9157	T11716	T11715	themeOf	induce,required
R9158	T11717	T11716	themeOf	Eomes,induce

PMC:2626671 / 21579-25275 JSONTXT

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PMC:2626671 / 21579-25275 JSON TXT