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PMC:2626671 / 15048-16186 JSONTXT

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bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T20185 10-13 NNP denotes Key
T20186 14-18 NN denotes role
T20187 19-22 IN denotes for
T20188 23-28 NNP denotes Runx3
T20189 29-31 IN denotes in
T20190 32-40 NN denotes effector
T20191 41-44 NNP denotes CTL
T20192 45-60 NN denotes differentiation
T20193 60-61 . denotes .
T20194 62-63 -LRB- denotes (
T20195 63-64 NNP denotes A
T20196 64-65 -RRB- denotes )
T20197 66-73 NNP denotes Western
T20198 74-82 NN denotes analysis
T20199 83-85 IN denotes of
T20200 86-91 NNP denotes Runx3
T20201 91-92 , denotes ,
T20202 93-98 NNP denotes Eomes
T20203 98-99 , denotes ,
T20204 100-105 NNP denotes T-bet
T20205 105-106 , denotes ,
T20206 107-110 CC denotes and
T20207 111-119 NN denotes perforin
T20208 120-130 NN denotes expression
T20209 131-133 IN denotes in
T20210 134-139 NNP denotes Runx3
T20211 139-140 NNP denotes +
T20212 140-141 VBD denotes /
T20213 141-142 CD denotes +
T20214 143-149 CC denotes versus
T20215 150-155 NNP denotes Runx3
T20216 155-156 FW denotes −
T20217 156-157 FW denotes /
T20218 157-158 FW denotes −
T20219 159-162 FW denotes CD8
T20220 162-163 FW denotes +
T20221 164-166 FW denotes SP
T20222 167-168 FW denotes T
T20223 169-174 NNS denotes cells
T20224 175-189 VBN denotes differentiated
T20225 190-193 IN denotes for
T20226 194-195 CD denotes 6
T20227 196-198 NN denotes d.
T20228 199-206 NN denotes β-Actin
T20229 207-210 VBD denotes was
T20230 211-215 VBN denotes used
T20231 216-218 IN denotes as
T20232 219-220 DT denotes a
T20233 221-228 VBG denotes loading
T20234 229-236 NN denotes control
T20235 236-237 . denotes .
T20236 238-239 -LRB- denotes (
T20237 239-240 NNP denotes B
T20238 240-241 -RRB- denotes )
T20239 242-250 NNP denotes Northern
T20240 251-255 NN denotes blot
T20241 256-264 NN denotes analysis
T20242 265-267 IN denotes of
T20243 268-272 NNP denotes Prf1
T20244 273-277 NNP denotes mRNA
T20245 278-288 NN denotes expression
T20246 289-291 IN denotes in
T20247 292-297 NNP denotes Runx3
T20248 297-298 NNP denotes +
T20249 298-299 VBD denotes /
T20250 299-300 CD denotes +
T20251 301-307 CC denotes versus
T20252 308-313 NNP denotes Runx3
T20253 313-314 FW denotes −
T20254 314-315 FW denotes /
T20255 315-316 FW denotes −
T20256 317-320 FW denotes CD8
T20257 320-321 FW denotes +
T20258 322-323 FW denotes T
T20259 324-329 NNS denotes cells
T20260 330-344 VBN denotes differentiated
T20261 345-348 IN denotes for
T20262 349-350 CD denotes 6
T20263 351-353 NN denotes d.
T20264 354-355 NN denotes β
T20265 356-361 NNP denotes Actin
T20266 362-365 VBD denotes was
T20267 366-370 VBN denotes used
T20268 371-373 IN denotes as
T20269 374-375 DT denotes a
T20270 376-383 VBG denotes loading
T20271 384-391 NN denotes control
T20272 391-392 . denotes .
T20273 393-394 -LRB- denotes (
T20274 394-395 $ denotes C
T20275 395-396 -RRB- denotes )
T20276 397-407 NN denotes Expression
T20277 408-410 IN denotes of
T20278 411-419 NN denotes granzyme
T20279 420-421 NNP denotes B
T20280 421-422 , denotes ,
T20281 423-428 NNP denotes IFN-γ
T20282 428-429 , denotes ,
T20283 430-433 NNP denotes TNF
T20284 433-434 , denotes ,
T20285 435-438 CC denotes and
T20286 439-443 NN denotes IL-2
T20287 444-446 IN denotes by
T20288 447-454 VBG denotes resting
T20289 455-457 CC denotes or
T20290 458-470 VBN denotes restimulated
T20291 471-472 -LRB- denotes (
T20292 472-473 CD denotes 6
T20293 474-475 NN denotes h
T20294 475-476 -RRB- denotes )
T20295 477-482 JJ denotes Runx3
T20296 482-483 NN denotes +
T20297 483-484 NN denotes /
T20298 484-485 NN denotes +
T20299 486-492 IN denotes versus
T20300 493-498 NNP denotes Runx3
T20301 498-499 NNP denotes −
T20302 499-500 VBD denotes /
T20303 500-501 CD denotes −
T20304 502-505 CD denotes CD8
T20305 505-506 NN denotes +
T20306 507-509 NNP denotes SP
T20307 510-511 NNP denotes T
T20308 512-517 NNS denotes cells
T20309 518-532 VBD denotes differentiated
T20310 533-536 IN denotes for
T20311 537-538 CD denotes 6
T20312 539-540 LS denotes d
T20313 540-541 . denotes .
T20314 542-545 DT denotes The
T20315 546-554 JJ denotes vertical
T20316 555-559 JJ denotes gray
T20317 560-564 NN denotes line
T20318 565-574 VBZ denotes indicates
T20319 575-578 DT denotes the
T20320 579-587 NN denotes granzyme
T20321 588-589 NNP denotes B
T20322 590-593 NNP denotes MFI
T20323 594-597 IN denotes for
T20324 598-600 NNP denotes WT
T20325 601-604 NNP denotes GFP
T20326 604-605 NN denotes +
T20327 606-611 NNS denotes cells
T20328 611-612 . denotes .
T20329 613-620 NNS denotes Results
T20330 621-623 IN denotes in
T20331 624-625 DT denotes A
T20332 626-627 NNP denotes C
T20333 628-631 VBP denotes are
T20334 632-646 JJ denotes representative
T20335 647-649 IN denotes of
T20336 650-653 CD denotes two
T20337 654-665 JJ denotes independent
T20338 666-677 NNS denotes experiments
T20339 677-678 . denotes .
T20340 679-680 -LRB- denotes (
T20341 680-681 NNP denotes D
T20342 681-682 -RRB- denotes )
T20343 683-687 NNP denotes ChIP
T20344 688-696 NN denotes analysis
T20345 697-699 IN denotes of
T20346 700-707 JJ denotes binding
T20347 708-710 IN denotes of
T20348 711-721 JJ denotes endogenous
T20349 722-727 NNP denotes Runx3
T20350 728-731 CC denotes and
T20351 732-737 NNP denotes Eomes
T20352 738-740 TO denotes to
T20353 741-744 DT denotes the
T20354 745-749 JJ denotes Prf1
T20355 750-755 NN denotes locus
T20356 755-756 . denotes .
T20357 757-767 NNP denotes Enrichment
T20358 768-770 IN denotes of
T20393 991-992 NNP denotes T
T20394 993-997 NN denotes cell
T20395 998-1014 NNS denotes differentiations
T20396 1014-1015 . denotes .
T20397 1016-1019 DT denotes The
T20398 1020-1030 NN denotes efficiency
T20399 1031-1033 IN denotes of
T20400 1034-1042 NN denotes recovery
T20401 1043-1045 IN denotes of
T20402 1046-1051 NN denotes input
T20403 1052-1055 IN denotes for
T20404 1056-1059 DT denotes the
T20405 1060-1061 NN denotes −
T20406 1061-1065 JJ denotes 1-kb
T20407 1066-1072 NN denotes region
T20408 1073-1075 IN denotes of
T20409 1076-1080 NNP denotes Prf1
T20410 1081-1084 VBD denotes was
T20411 1085-1089 CD denotes 0.97
T20412 1089-1090 NN denotes %
T20413 1091-1094 IN denotes for
T20414 1095-1098 DT denotes the
T20415 1099-1104 NNP denotes Runx3
T20416 1105-1109 NNP denotes ChIP
T20417 1110-1113 CC denotes and
T20418 1114-1117 CD denotes 0.5
T20419 1117-1118 NN denotes %
T20420 1119-1122 IN denotes for
T20421 1123-1126 DT denotes the
T20422 1127-1132 NNP denotes Eomes
T20423 1133-1137 NNP denotes ChIP
T20424 1137-1138 . denotes .
T20359 771-774 DT denotes the
T20360 775-784 VBN denotes indicated
T20361 785-792 JJ denotes genomic
T20362 793-800 NNS denotes regions
T20363 801-804 VBD denotes was
T20364 805-814 VBN denotes evaluated
T20365 815-817 IN denotes by
T20366 818-827 JJ denotes real-time
T20367 828-831 NNP denotes PCR
T20368 832-834 IN denotes of
T20369 835-838 NNP denotes DNA
T20370 839-843 IN denotes from
T20371 844-862 JJ denotes immunoprecipitated
T20372 863-866 CC denotes and
T20373 867-872 NN denotes input
T20374 873-882 NN denotes chromatin
T20375 882-883 . denotes .
T20376 884-887 DT denotes The
T20377 888-892 NNS denotes data
T20378 893-896 VBP denotes are
T20379 897-900 DT denotes the
T20380 901-906 NNS denotes means
T20381 907-909 IN denotes of
T20382 910-919 VBP denotes duplicate
T20383 920-932 NNS denotes measurements
T20384 933-937 IN denotes from
T20385 938-941 CD denotes two
T20386 942-951 NN denotes chromatin
T20387 952-964 NNS denotes preparations
T20388 965-969 IN denotes from
T20389 970-973 CD denotes two
T20390 974-985 JJ denotes independent
T20391 986-989 NNP denotes CD8
T20392 989-990 CD denotes +
R15553 T20185 T20186 amod Key,role
R15554 T20186 T20186 ROOT role,role
R15555 T20187 T20186 prep for,role
R15556 T20188 T20187 pobj Runx3,for
R15557 T20189 T20186 prep in,role
R15558 T20190 T20191 compound effector,CTL
R15559 T20191 T20192 compound CTL,differentiation
R15560 T20192 T20189 pobj differentiation,in
R15561 T20193 T20186 punct .,role
R15562 T20194 T20198 punct (,analysis
R15563 T20195 T20198 nmod A,analysis
R15564 T20196 T20195 punct ),A
R15565 T20197 T20198 amod Western,analysis
R15566 T20198 T20212 nsubj analysis,/
R15567 T20199 T20198 prep of,analysis
R15568 T20200 T20199 pobj Runx3,of
R15569 T20201 T20200 punct ",",Runx3
R15570 T20202 T20200 conj Eomes,Runx3
R15571 T20203 T20202 punct ",",Eomes
R15572 T20204 T20202 conj T-bet,Eomes
R15573 T20205 T20204 punct ",",T-bet
R15574 T20206 T20204 cc and,T-bet
R15575 T20207 T20208 compound perforin,expression
R15576 T20208 T20198 conj expression,analysis
R15577 T20209 T20198 prep in,analysis
R15578 T20210 T20211 compound Runx3,+
R15579 T20211 T20209 pobj +,in
R15580 T20212 T20212 ROOT /,/
R15581 T20213 T20223 nummod +,cells
R15582 T20214 T20213 cc versus,+
R15583 T20215 T20223 nmod Runx3,cells
R15584 T20216 T20223 nmod −,cells
R15585 T20217 T20223 nmod /,cells
R15586 T20218 T20223 nmod −,cells
R15587 T20219 T20223 nmod CD8,cells
R15588 T20220 T20223 nmod +,cells
R15589 T20221 T20223 nmod SP,cells
R15590 T20222 T20223 compound T,cells
R15591 T20223 T20224 nsubj cells,differentiated
R15592 T20224 T20212 ccomp differentiated,/
R15593 T20225 T20224 prep for,differentiated
R15594 T20226 T20228 nummod 6,β-Actin
R15595 T20227 T20228 compound d.,β-Actin
R15596 T20228 T20225 pobj β-Actin,for
R15597 T20229 T20230 auxpass was,used
R15598 T20230 T20212 conj used,/
R15599 T20231 T20230 prep as,used
R15600 T20232 T20234 det a,control
R15601 T20233 T20234 compound loading,control
R15602 T20234 T20231 pobj control,as
R15603 T20235 T20212 punct .,/
R15604 T20236 T20241 punct (,analysis
R15605 T20237 T20241 nmod B,analysis
R15606 T20238 T20237 punct ),B
R15607 T20239 T20240 compound Northern,blot
R15608 T20240 T20241 compound blot,analysis
R15609 T20241 T20249 nsubj analysis,/
R15610 T20242 T20241 prep of,analysis
R15611 T20243 T20244 compound Prf1,mRNA
R15612 T20244 T20245 compound mRNA,expression
R15613 T20245 T20242 pobj expression,of
R15614 T20246 T20241 prep in,analysis
R15615 T20247 T20248 compound Runx3,+
R15616 T20248 T20246 pobj +,in
R15617 T20249 T20267 ccomp /,used
R15618 T20250 T20259 nummod +,cells
R15619 T20251 T20250 cc versus,+
R15620 T20252 T20259 nmod Runx3,cells
R15621 T20253 T20259 nmod −,cells
R15622 T20254 T20259 nmod /,cells
R15623 T20255 T20259 nmod −,cells
R15624 T20256 T20259 nmod CD8,cells
R15625 T20257 T20259 nmod +,cells
R15626 T20258 T20259 compound T,cells
R15627 T20259 T20260 nsubj cells,differentiated
R15628 T20260 T20249 ccomp differentiated,/
R15629 T20261 T20260 prep for,differentiated
R15630 T20262 T20264 nummod 6,β
R15631 T20263 T20264 compound d.,β
R15632 T20264 T20261 pobj β,for
R15633 T20265 T20267 nsubjpass Actin,used
R15634 T20266 T20267 auxpass was,used
R15635 T20267 T20267 ROOT used,used
R15636 T20268 T20267 prep as,used
R15637 T20269 T20271 det a,control
R15638 T20270 T20271 compound loading,control
R15639 T20271 T20268 pobj control,as
R15640 T20272 T20267 punct .,used
R15641 T20273 T20274 punct (,C
R15642 T20274 T20276 compound C,Expression
R15643 T20275 T20274 punct ),C
R15644 T20276 T20276 ROOT Expression,Expression
R15645 T20277 T20276 prep of,Expression
R15646 T20278 T20279 compound granzyme,B
R15647 T20279 T20277 pobj B,of
R15648 T20280 T20279 punct ",",B
R15649 T20281 T20279 appos IFN-γ,B
R15650 T20282 T20281 punct ",",IFN-γ
R15651 T20283 T20281 conj TNF,IFN-γ
R15652 T20284 T20283 punct ",",TNF
R15653 T20285 T20283 cc and,TNF
R15654 T20286 T20283 conj IL-2,TNF
R15655 T20287 T20276 prep by,Expression
R15656 T20288 T20287 pcomp resting,by
R15657 T20289 T20288 cc or,resting
R15658 T20290 T20288 conj restimulated,resting
R15659 T20291 T20290 punct (,restimulated
R15660 T20292 T20293 nummod 6,h
R15661 T20293 T20290 appos h,restimulated
R15662 T20294 T20290 punct ),restimulated
R15663 T20295 T20298 amod Runx3,+
R15664 T20296 T20298 compound +,+
R15665 T20297 T20298 compound /,+
R15666 T20298 T20298 ROOT +,+
R15667 T20299 T20302 prep versus,/
R15668 T20300 T20301 compound Runx3,−
R15669 T20301 T20302 nsubj −,/
R15670 T20302 T20302 ROOT /,/
R15671 T20303 T20308 nummod −,cells
R15672 T20304 T20308 nummod CD8,cells
R15673 T20305 T20308 compound +,cells
R15674 T20306 T20307 compound SP,T
R15675 T20307 T20308 compound T,cells
R15676 T20308 T20309 nsubj cells,differentiated
R15677 T20309 T20302 acl differentiated,/
R15678 T20310 T20309 prep for,differentiated
R15679 T20311 T20312 nummod 6,d
R15680 T20312 T20310 pobj d,for
R15681 T20313 T20309 punct .,differentiated
R15682 T20314 T20317 det The,line
R15683 T20315 T20317 amod vertical,line
R15684 T20316 T20317 amod gray,line
R15685 T20317 T20318 nsubj line,indicates
R15686 T20318 T20318 ROOT indicates,indicates
R15687 T20319 T20322 det the,MFI
R15688 T20320 T20322 compound granzyme,MFI
R15689 T20321 T20322 compound B,MFI
R15690 T20322 T20318 dobj MFI,indicates
R15691 T20323 T20322 prep for,MFI
R15692 T20324 T20325 compound WT,GFP
R15693 T20325 T20327 compound GFP,cells
R15694 T20326 T20327 compound +,cells
R15695 T20327 T20323 pobj cells,for
R15696 T20328 T20318 punct .,indicates
R15697 T20329 T20333 nsubj Results,are
R15698 T20330 T20329 prep in,Results
R15699 T20331 T20330 pobj A,in
R15700 T20332 T20333 nsubj C,are
R15701 T20333 T20333 ROOT are,are
R15702 T20334 T20333 attr representative,are
R15703 T20335 T20334 prep of,representative
R15704 T20336 T20338 nummod two,experiments
R15705 T20337 T20338 amod independent,experiments
R15706 T20338 T20335 pobj experiments,of
R15707 T20339 T20333 punct .,are
R15708 T20340 T20344 punct (,analysis
R15709 T20341 T20344 compound D,analysis
R15710 T20342 T20343 punct ),ChIP
R15711 T20343 T20344 compound ChIP,analysis
R15712 T20344 T20344 ROOT analysis,analysis
R15713 T20345 T20344 prep of,analysis
R15714 T20346 T20345 pcomp binding,of
R15715 T20347 T20346 prep of,binding
R15716 T20348 T20349 compound endogenous,Runx3
R15717 T20349 T20347 pobj Runx3,of
R15718 T20350 T20349 cc and,Runx3
R15719 T20351 T20349 conj Eomes,Runx3
R15720 T20352 T20344 prep to,analysis
R15721 T20353 T20355 det the,locus
R15722 T20354 T20355 amod Prf1,locus
R15723 T20355 T20352 pobj locus,to
R15724 T20356 T20344 punct .,analysis
R15725 T20357 T20364 nsubjpass Enrichment,evaluated
R15726 T20358 T20357 prep of,Enrichment
R15727 T20359 T20362 det the,regions
R15728 T20360 T20362 amod indicated,regions
R15729 T20361 T20362 amod genomic,regions
R15730 T20362 T20358 pobj regions,of
R15731 T20363 T20364 auxpass was,evaluated
R15732 T20364 T20364 ROOT evaluated,evaluated
R15733 T20365 T20364 agent by,evaluated
R15734 T20366 T20367 amod real-time,PCR
R15735 T20367 T20365 pobj PCR,by
R15736 T20368 T20367 prep of,PCR
R15737 T20369 T20368 pobj DNA,of
R15738 T20370 T20364 prep from,evaluated
R15739 T20371 T20370 pobj immunoprecipitated,from
R15740 T20372 T20371 cc and,immunoprecipitated
R15741 T20373 T20374 compound input,chromatin
R15742 T20374 T20371 conj chromatin,immunoprecipitated
R15743 T20375 T20364 punct .,evaluated
R15744 T20376 T20377 det The,data
R15745 T20377 T20378 nsubj data,are
R15746 T20378 T20378 ROOT are,are
R15747 T20379 T20380 det the,means
R15748 T20380 T20378 attr means,are
R15749 T20381 T20380 prep of,means
R15750 T20382 T20381 pcomp duplicate,of
R15751 T20383 T20382 dobj measurements,duplicate
R15752 T20384 T20382 prep from,duplicate
R15753 T20385 T20387 nummod two,preparations
R15754 T20386 T20387 amod chromatin,preparations
R15755 T20387 T20384 pobj preparations,from
R15756 T20388 T20387 prep from,preparations
R15757 T20389 T20395 nummod two,differentiations
R15758 T20390 T20395 amod independent,differentiations
R15759 T20391 T20395 compound CD8,differentiations
R15760 T20392 T20395 nummod +,differentiations
R15761 T20393 T20394 compound T,cell
R15762 T20394 T20395 compound cell,differentiations
R15763 T20395 T20388 pobj differentiations,from
R15764 T20396 T20378 punct .,are
R15765 T20397 T20398 det The,efficiency
R15766 T20398 T20410 nsubj efficiency,was
R15767 T20399 T20398 prep of,efficiency
R15768 T20400 T20399 pobj recovery,of
R15769 T20401 T20400 prep of,recovery
R15770 T20402 T20401 pobj input,of
R15771 T20403 T20402 prep for,input
R15772 T20404 T20407 det the,region
R15773 T20405 T20407 amod −,region
R15774 T20406 T20407 amod 1-kb,region
R15775 T20407 T20403 pobj region,for
R15776 T20408 T20407 prep of,region
R15777 T20409 T20408 pobj Prf1,of
R15778 T20410 T20410 ROOT was,was
R15779 T20411 T20412 nummod 0.97,%
R15780 T20412 T20410 attr %,was
R15781 T20413 T20410 prep for,was
R15782 T20414 T20416 det the,ChIP
R15783 T20415 T20416 compound Runx3,ChIP
R15784 T20416 T20413 pobj ChIP,for
R15785 T20417 T20410 cc and,was
R15786 T20418 T20419 nummod 0.5,%
R15787 T20419 T20410 conj %,was
R15788 T20420 T20419 prep for,%
R15789 T20421 T20423 det the,ChIP
R15790 T20422 T20423 compound Eomes,ChIP
R15791 T20423 T20420 pobj ChIP,for
R15792 T20424 T20410 punct .,was

GO-BP

Id Subject Object Predicate Lexical cue
T20181 169-189 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiated
T20182 324-344 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiated
T20183 512-532 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiated
T20184 993-1014 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiations

GO-MF

Id Subject Object Predicate Lexical cue
T20465 439-443 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T20466 700-707 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T20467 169-174 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20468 324-329 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20469 512-517 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20470 606-611 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20471 993-997 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20472 873-882 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T20473 942-951 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin

sentences

Id Subject Object Predicate Lexical cue
T20175 10-541 Sentence denotes Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3−/− CD8+ SP T cells differentiated for 6 d. β-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3−/− CD8+ T cells differentiated for 6 d. β–Actin was used as a loading control. (C) Expression of granzyme B, IFN-γ, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3−/− CD8+ SP T cells differentiated for 6 d.
T20176 542-612 Sentence denotes The vertical gray line indicates the granzyme B MFI for WT GFP+ cells.
T20177 613-756 Sentence denotes Results in A–C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus.
T20178 757-883 Sentence denotes Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin.
T20179 884-1015 Sentence denotes The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations.
T20180 1016-1138 Sentence denotes The efficiency of recovery of input for the −1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.
T92 0-9 Sentence denotes Figure 3.
T93 10-541 Sentence denotes Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3−/− CD8+ SP T cells differentiated for 6 d. β-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3−/− CD8+ T cells differentiated for 6 d. β–Actin was used as a loading control. (C) Expression of granzyme B, IFN-γ, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3−/− CD8+ SP T cells differentiated for 6 d.
T94 542-612 Sentence denotes The vertical gray line indicates the granzyme B MFI for WT GFP+ cells.
T95 613-756 Sentence denotes Results in A–C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus.
T96 757-883 Sentence denotes Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin.
T97 884-1015 Sentence denotes The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations.

events-check-again

Id Subject Object Predicate Lexical cue Speculation
T20666 23-28 Protein denotes Runx3
T20667 86-91 Protein denotes Runx3
T20668 93-98 Protein denotes Eomes
T20669 100-105 Protein denotes T-bet
T20670 111-119 Protein denotes perforin
T20671 120-130 Gene_expression denotes expression true
T20672 120-130 Gene_expression denotes expression true
T20673 120-130 Gene_expression denotes expression true
T20674 120-130 Gene_expression denotes expression true
T20675 134-139 Protein denotes Runx3
T20676 150-155 Protein denotes Runx3
T20677 159-162 Protein denotes CD8
T20678 199-206 Protein denotes β-Actin
T20679 268-272 Protein denotes Prf1
T20680 273-288 Transcription denotes mRNA expression true
T20681 292-297 Protein denotes Runx3
T20682 308-313 Protein denotes Runx3
T20683 317-320 Protein denotes CD8
T20684 354-361 Protein denotes β–Actin
T20685 397-407 Gene_expression denotes Expression true
T20686 397-407 Gene_expression denotes Expression true
T20687 397-407 Gene_expression denotes Expression true
T20688 397-407 Gene_expression denotes Expression true
T20689 411-421 Protein denotes granzyme B
T20690 423-428 Protein denotes IFN-γ
T20691 430-433 Protein denotes TNF
T20692 439-443 Protein denotes IL-2
T20693 477-482 Protein denotes Runx3
T20694 493-498 Protein denotes Runx3
T20695 502-505 Protein denotes CD8
T20696 579-589 Protein denotes granzyme B
T20697 601-604 Protein denotes GFP
T20698 700-707 Binding denotes binding true
T20699 700-707 Binding denotes binding true
T20700 722-727 Protein denotes Runx3
T20701 732-737 Protein denotes Eomes
T20702 745-749 Protein denotes Prf1
T20703 986-989 Protein denotes CD8
T20704 1076-1080 Protein denotes Prf1
T20705 1099-1104 Protein denotes Runx3
T20706 1127-1132 Protein denotes Eomes
R15854 T20667 T20673 themeOf Runx3,expression
R15855 T20668 T20674 themeOf Eomes,expression
R15856 T20669 T20671 themeOf T-bet,expression
R15857 T20670 T20672 themeOf perforin,expression
R15858 T20679 T20680 themeOf Prf1,mRNA expression
R15859 T20689 T20685 themeOf granzyme B,Expression
R15860 T20690 T20686 themeOf IFN-γ,Expression
R15861 T20691 T20688 themeOf TNF,Expression
R15862 T20692 T20687 themeOf IL-2,Expression
R15863 T20700 T20699 themeOf Runx3,binding
R15864 T20701 T20698 themeOf Eomes,binding
R15865 T20702 T20699 themeOf Prf1,binding
R15866 T20702 T20698 themeOf Prf1,binding

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T20707 23-28 Protein denotes Runx3
T20708 86-91 Protein denotes Runx3
T20709 111-119 Protein denotes perforin
T20710 134-139 Protein denotes Runx3
T20711 159-162 Protein denotes CD8
T20712 164-168 Protein denotes SP T
T20713 120-130 Gene_expression denotes expression
T20714 120-130 Gene_expression denotes expression
T20715 201-206 Protein denotes Actin
T20716 268-277 Protein denotes Prf1 mRNA
T20717 292-297 Protein denotes Runx3
T20718 317-320 Protein denotes CD8
T20719 278-288 Gene_expression denotes expression
T20720 356-361 Protein denotes Actin
T20721 411-421 Protein denotes granzyme B
T20722 423-428 Protein denotes IFN-γ
T20723 430-433 Protein denotes TNF
T20724 439-443 Protein denotes IL-2
T20725 477-482 Protein denotes Runx3
T20726 502-505 Protein denotes CD8
T20727 507-511 Protein denotes SP T
T20728 397-407 Gene_expression denotes Expression
T20729 397-407 Gene_expression denotes Expression
T20730 397-407 Gene_expression denotes Expression
T20731 397-407 Gene_expression denotes Expression
T20732 598-604 Protein denotes WT GFP
T20733 711-727 Protein denotes endogenous Runx3
T20734 732-737 Protein denotes Eomes
T20735 745-755 Protein denotes Prf1 locus
T20736 700-707 Binding denotes binding
T20737 700-707 Binding denotes binding
T20738 700-707 Binding denotes binding
T20739 700-707 Binding denotes binding
T20740 986-990 Protein denotes CD8+
T20741 1076-1080 Protein denotes Prf1
T20742 1099-1109 Protein denotes Runx3 ChIP
T20743 1127-1137 Protein denotes Eomes ChIP
R15867 T20708 T20713 themeOf Runx3,expression
R15868 T20709 T20714 themeOf perforin,expression
R15869 T20716 T20719 themeOf Prf1 mRNA,expression
R15870 T20721 T20728 themeOf granzyme B,Expression
R15871 T20722 T20729 themeOf IFN-γ,Expression
R15872 T20723 T20730 themeOf TNF,Expression
R15873 T20724 T20731 themeOf IL-2,Expression
R15874 T20733 T20736 themeOf endogenous Runx3,binding
R15875 T20733 T20738 themeOf endogenous Runx3,binding
R15876 T20734 T20737 themeOf Eomes,binding
R15877 T20734 T20739 themeOf Eomes,binding
R15878 T20735 T20738 themeOf Prf1 locus,binding
R15879 T20735 T20739 themeOf Prf1 locus,binding

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Speculation
T20168 722-727 Protein denotes Runx3
T20169 732-737 Protein denotes Eomes
T20170 745-749 Protein denotes Prf1
T20134 23-28 Protein denotes Runx3
T20135 86-91 Protein denotes Runx3
T20136 93-98 Protein denotes Eomes
T20137 100-105 Protein denotes T-bet
T20138 111-119 Protein denotes perforin
T20139 120-130 Gene_expression denotes expression true
T20140 120-130 Gene_expression denotes expression true
T20141 120-130 Gene_expression denotes expression true
T20142 120-130 Gene_expression denotes expression true
T20143 134-139 Protein denotes Runx3
T20144 150-155 Protein denotes Runx3
T20145 159-162 Protein denotes CD8
T20146 199-206 Protein denotes β-Actin
T20147 268-272 Protein denotes Prf1
T20148 273-288 Transcription denotes mRNA expression true
T20149 292-297 Protein denotes Runx3
T20150 308-313 Protein denotes Runx3
T20151 317-320 Protein denotes CD8
T20152 354-361 Protein denotes β–Actin
T20153 397-407 Gene_expression denotes Expression true
T20154 397-407 Gene_expression denotes Expression true
T20155 397-407 Gene_expression denotes Expression true
T20156 397-407 Gene_expression denotes Expression true
T20157 411-421 Protein denotes granzyme B
T20158 423-428 Protein denotes IFN-γ
T20159 430-433 Protein denotes TNF
T20160 439-443 Protein denotes IL-2
T20161 477-482 Protein denotes Runx3
T20162 493-498 Protein denotes Runx3
T20163 502-505 Protein denotes CD8
T20164 579-589 Protein denotes granzyme B
T20165 601-604 Protein denotes GFP
T20166 700-707 Binding denotes binding true
T20167 700-707 Binding denotes binding true
T20171 986-989 Protein denotes CD8
T20172 1076-1080 Protein denotes Prf1
T20173 1099-1104 Protein denotes Runx3
T20174 1127-1132 Protein denotes Eomes
R15540 T20135 T20141 themeOf Runx3,expression
R15541 T20136 T20142 themeOf Eomes,expression
R15542 T20137 T20139 themeOf T-bet,expression
R15543 T20138 T20140 themeOf perforin,expression
R15544 T20147 T20148 themeOf Prf1,mRNA expression
R15545 T20157 T20153 themeOf granzyme B,Expression
R15546 T20158 T20154 themeOf IFN-γ,Expression
R15547 T20159 T20156 themeOf TNF,Expression
R15548 T20160 T20155 themeOf IL-2,Expression
R15549 T20168 T20167 themeOf Runx3,binding
R15550 T20169 T20166 themeOf Eomes,binding
R15551 T20170 T20167 themeOf Prf1,binding
R15552 T20170 T20166 themeOf Prf1,binding

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T20425 23-28 Q13761 denotes Runx3
T20426 86-91 Q13761 denotes Runx3
T20427 93-98 O95936 denotes Eomes
T20428 100-105 Q9UL17 denotes T-bet
T20429 111-119 P14222 denotes perforin
T20430 134-139 Q13761 denotes Runx3
T20431 150-155 Q13761 denotes Runx3
T20432 159-162 P01732 denotes CD8
T20433 159-162 P10966 denotes CD8
T20434 199-206 P60709 denotes β-Actin
T20435 268-272 P14222 denotes Prf1
T20436 292-297 Q13761 denotes Runx3
T20437 308-313 Q13761 denotes Runx3
T20438 317-320 P10966 denotes CD8
T20439 317-320 P01732 denotes CD8
T20440 354-361 P60709 denotes β–Actin
T20441 411-421 P10144 denotes granzyme B
T20442 423-428 P01579 denotes IFN-γ
T20443 430-433 P01375 denotes TNF
T20444 439-443 P60568 denotes IL-2
T20445 477-482 Q13761 denotes Runx3
T20446 493-498 Q13761 denotes Runx3
T20447 502-505 P01732 denotes CD8
T20448 502-505 P10966 denotes CD8
T20449 579-589 P10144 denotes granzyme B
T20450 601-604 Q9U6Y4 denotes GFP
T20451 722-727 Q13761 denotes Runx3
T20452 732-737 O95936 denotes Eomes
T20453 745-749 P14222 denotes Prf1
T20454 986-989 P10966 denotes CD8
T20455 986-989 P01732 denotes CD8
T20456 1076-1080 P14222 denotes Prf1
T20457 1099-1104 Q13761 denotes Runx3
T20458 1127-1132 O95936 denotes Eomes

test2

Id Subject Object Predicate Lexical cue Speculation
T20100 23-28 Protein denotes Runx3 true
T20101 86-91 Protein denotes Runx3 true
T20102 93-98 Protein denotes Eomes true
T20103 100-105 Protein denotes T-bet true
T20104 111-119 Protein denotes perforin true
T20105 120-130 Gene_expression denotes expression true
T20106 134-139 Protein denotes Runx3 true
T20107 150-155 Protein denotes Runx3 true
T20108 159-162 Protein denotes CD8 true
T20109 199-206 Protein denotes β-Actin true
T20110 268-272 Protein denotes Prf1 true
T20111 273-288 Transcription denotes mRNA expression
T20112 292-297 Protein denotes Runx3
T20113 308-313 Protein denotes Runx3
T20114 317-320 Protein denotes CD8
T20115 354-361 Protein denotes β–Actin
T20116 397-407 Gene_expression denotes Expression
T20117 411-421 Protein denotes granzyme B
T20118 423-428 Protein denotes IFN-γ
T20119 430-433 Protein denotes TNF
T20120 439-443 Protein denotes IL-2
T20121 477-482 Protein denotes Runx3
T20122 493-498 Protein denotes Runx3
T20123 502-505 Protein denotes CD8
T20124 579-589 Protein denotes granzyme B
T20125 601-604 Protein denotes GFP
T20126 700-707 Binding denotes binding
T20127 722-727 Protein denotes Runx3
T20128 732-737 Protein denotes Eomes
T20129 745-749 Protein denotes Prf1
T20130 986-989 Protein denotes CD8
T20131 1076-1080 Protein denotes Prf1
T20132 1099-1104 Protein denotes Runx3
T20133 1127-1132 Protein denotes Eomes
R15528 T20101 T20105 themeOf Runx3,expression
R15529 T20102 T20105 themeOf Eomes,expression
R15530 T20103 T20105 themeOf T-bet,expression
R15531 T20104 T20105 themeOf perforin,expression
R15532 T20110 T20111 themeOf Prf1,mRNA expression
R15533 T20117 T20116 themeOf granzyme B,Expression
R15534 T20118 T20116 themeOf IFN-γ,Expression
R15535 T20119 T20116 themeOf TNF,Expression
R15536 T20120 T20116 themeOf IL-2,Expression
R15537 T20127 T20126 themeOf Runx3,binding
R15538 T20128 T20126 themeOf Eomes,binding
R15539 T20129 T20126 themeOf Prf1,binding