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2_test

Id Subject Object Predicate Lexical cue
19139168-17195845-59674050 245-247 17195845 denotes 15
19139168-17195845-59674051 2569-2571 17195845 denotes 15
19139168-17242680-59674052 2573-2575 17242680 denotes 22
19139168-10544201-59674053 3638-3640 10544201 denotes 23
19139168-17222571-59674054 3719-3721 17222571 denotes 24
19139168-17646406-59674055 3797-3799 17646406 denotes 10
19139168-17981204-59674056 3893-3895 17981204 denotes 25
19139168-16273099-59674057 4085-4086 16273099 denotes 8
19139168-11786644-59674058 4212-4214 11786644 denotes 17
19139168-12464175-59674059 7124-7126 12464175 denotes 12
19139168-12464175-59674060 7253-7255 12464175 denotes 12
19139168-12796513-59674061 7395-7397 12796513 denotes 13

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T8977 0-5 NN denotes Runx3
T8978 6-14 VB denotes controls
T8979 15-23 JJ denotes multiple
T8980 24-31 NN denotes aspects
T8981 32-34 IN denotes of
T8982 35-38 DT denotes the
T8983 39-42 NN denotes CTL
T8984 43-58 NN denotes differentiation
T8985 59-66 NN denotes program
T8986 66-67 -COMMA- denotes ,
T8987 68-70 IN denotes in
T8988 71-75 NN denotes part
T8989 76-83 IN denotes through
T8990 84-93 NN denotes induction
T8991 94-96 IN denotes of
T8992 97-102 NN denotes Eomes
T8993 103-110 IN denotes Because
T8994 111-116 NN denotes Runx3
T8995 117-119 VB denotes is
T8996 120-126 RB denotes highly
T8997 127-136 VB denotes expressed
T8998 137-139 IN denotes in
T8999 140-150 JJ denotes peripheral
T9000 151-155 JJ denotes CD8+
T9001 156-157 NN denotes T
T9002 158-163 NN denotes cells
T9003 163-164 -COMMA- denotes ,
T9004 165-168 CC denotes and
T9005 169-176 IN denotes because
T9006 177-179 IN denotes of
T9007 180-183 DT denotes the
T9008 184-195 NN denotes T-bet-Runx3
T9009 196-207 NN denotes cooperation
T9010 208-210 PRP denotes we
T9011 211-219 VB denotes observed
T9012 220-227 RB denotes earlier
T9013 228-230 IN denotes in
T9014 231-235 JJ denotes CD4+
T9015 236-237 NN denotes T
T9016 238-243 NN denotes cells
T9017 244-245 -LRB- denotes (
T9018 245-247 CD denotes 15
T9019 247-248 -RRB- denotes )
T9020 248-249 -COMMA- denotes ,
T9021 250-252 PRP denotes we
T9022 253-261 VB denotes examined
T9023 262-265 DT denotes the
T9024 266-270 NN denotes role
T9025 271-273 IN denotes of
T9026 274-279 NN denotes Runx3
T9027 280-282 IN denotes in
T9028 283-291 NN denotes effector
T9029 292-295 NN denotes CTL
T9030 296-311 NN denotes differentiation
T9031 313-315 PRP denotes We
T9032 316-324 VB denotes isolated
T9033 325-329 JJ denotes CD8+
T9034 330-331 NN denotes T
T9035 332-337 NN denotes cells
T9036 338-342 IN denotes from
T9037 343-351 NN denotes Runx3−/−
T9038 352-353 -LRB- denotes (
T9039 353-355 NN denotes KO
T9040 355-356 -RRB- denotes )
T9041 357-361 NN denotes mice
T9042 362-364 IN denotes of
T9043 365-368 DT denotes the
T9044 369-376 JJ denotes outbred
T9045 377-380 NN denotes ICR
T9046 381-391 NN denotes background
T9047 392-395 CC denotes and
T9048 396-401 PRP-DOLLAR- denotes their
T9049 402-404 JJ denotes WT
T9050 405-413 NN denotes Runx3+/+
T9051 414-425 NN denotes littermates
T9052 426-428 IN denotes by
T9053 429-437 JJ denotes positive
T9054 438-447 NN denotes selection
T9055 448-452 IN denotes with
T9056 453-461 JJ denotes anti-CD8
T9057 462-470 JJ denotes magnetic
T9058 471-476 NN denotes beads
T9059 477-478 -LRB- denotes (
T9060 478-483 NN denotes Figs.
T9061 484-486 NN denotes S1
T9062 487-490 CC denotes and
T9063 491-493 NN denotes S2
T9064 493-494 -COMMA- denotes ,
T9065 495-504 JJ denotes available
T9066 505-507 IN denotes at
T9067 508-512 NN denotes http
T9068 512-513 -COLON- denotes :
T9069 513-560 NN denotes //www.jem.org/cgi/content/full/jem.20081242/DC1
T9070 560-561 -RRB- denotes )
T9071 563-573 RB denotes Strikingly
T9072 573-574 -COMMA- denotes ,
T9073 575-583 NN denotes Runx3−/−
T9074 584-588 JJ denotes CD8+
T9075 589-590 NN denotes T
T9076 591-596 NN denotes cells
T9077 597-601 VB denotes were
T9078 602-610 RB denotes strongly
T9079 611-619 JJ denotes impaired
T9080 620-622 IN denotes in
T9081 623-628 PRP-DOLLAR- denotes their
T9082 629-636 NN denotes ability
T9083 637-639 TO denotes to
T9084 640-653 VB denotes differentiate
T9085 654-658 IN denotes into
T9086 659-667 NN denotes effector
T9087 668-672 NN denotes CTLs
T9088 672-673 -COMMA- denotes ,
T9089 674-676 IN denotes as
T9090 677-683 VB denotes judged
T9091 684-686 IN denotes by
T9092 687-697 NN denotes expression
T9093 698-700 IN denotes of
T9094 701-709 NN denotes perforin
T9095 709-710 -COMMA- denotes ,
T9096 711-719 NN denotes granzyme
T9097 720-721 NN denotes B
T9098 721-722 -COMMA- denotes ,
T9099 723-726 CC denotes and
T9100 727-732 NN denotes IFN-γ
T9101 733-734 -LRB- denotes (
T9102 734-738 NN denotes Fig.
T9103 739-740 CD denotes 3
T9104 740-741 -RRB- denotes )
T9105 743-751 VB denotes Compared
T9106 752-756 IN denotes with
T9107 757-759 JJ denotes WT
T9108 760-761 NN denotes T
T9109 762-767 NN denotes cells
T9110 767-768 -COMMA- denotes ,
T9111 769-777 NN denotes perforin
T9112 778-782 NN denotes mRNA
T9113 783-786 CC denotes and
T9114 787-794 NN denotes protein
T9115 795-805 NN denotes expression
T9116 806-810 VB denotes were
T9117 811-822 RB denotes essentially
T9118 823-835 JJ denotes undetectable
T9119 836-838 IN denotes in
T9120 839-847 NN denotes Runx3−/−
T9121 848-849 NN denotes T
T9122 850-855 NN denotes cells
T9123 856-858 IN denotes at
T9124 859-862 NN denotes day
T9125 863-864 CD denotes 6
T9126 865-867 IN denotes of
T9127 868-875 NN denotes culture
T9128 876-877 -LRB- denotes (
T9129 877-881 NNP denotes Fig.
T9130 882-883 CD denotes 3
T9131 883-884 -COMMA- denotes ,
T9132 885-886 NN denotes A
T9133 887-890 CC denotes and
T9134 891-892 NN denotes B
T9135 892-893 -RRB- denotes )
T9136 895-903 NN denotes Runx3−/−
T9137 904-905 NN denotes T
T9138 906-911 NN denotes cells
T9139 912-916 RB denotes also
T9140 917-920 VB denotes had
T9141 921-923 DT denotes no
T9142 924-934 JJ denotes detectable
T9143 935-940 NN denotes Eomes
T9144 941-951 NN denotes expression
T9145 951-952 -COLON- denotes ;
T9146 953-955 IN denotes in
T9147 956-964 NN denotes contrast
T9148 964-965 -COMMA- denotes ,
T9149 966-971 NN denotes T-bet
T9150 972-982 NN denotes expression
T9151 983-986 VB denotes was
T9152 987-997 JJ denotes unimpaired
T9153 998-999 -LRB- denotes (
T9154 999-1003 NN denotes Fig.
T9155 1004-1005 CD denotes 3
T9156 1006-1007 NN denotes A
T9157 1007-1008 -RRB- denotes )
T9158 1010-1021 RB denotes Furthermore
T9159 1021-1022 -COMMA- denotes ,
T9160 1023-1028 NN denotes Runx3
T9161 1029-1032 VB denotes was
T9162 1033-1041 VB denotes required
T9163 1042-1045 IN denotes for
T9164 1046-1053 JJ denotes maximal
T9165 1054-1064 NN denotes production
T9166 1065-1067 IN denotes of
T9167 1068-1073 NN denotes IFN-γ
T9168 1073-1074 -COMMA- denotes ,
T9169 1075-1078 CC denotes but
T9170 1079-1082 RB denotes not
T9171 1083-1086 NN denotes TNF
T9172 1087-1089 CC denotes or
T9173 1090-1094 NN denotes IL-2
T9174 1094-1095 -COMMA- denotes ,
T9175 1096-1098 IN denotes by
T9176 1099-1103 JJ denotes CD8+
T9177 1104-1105 NN denotes T
T9178 1106-1111 NN denotes cells
T9179 1112-1124 VB denotes restimulated
T9180 1125-1127 IN denotes at
T9181 1128-1131 NN denotes day
T9182 1132-1133 CD denotes 6
T9183 1134-1135 -LRB- denotes (
T9184 1135-1139 NN denotes Fig.
T9185 1140-1141 CD denotes 3
T9186 1142-1143 NN denotes C
T9187 1143-1144 -RRB- denotes )
T9188 2284-2286 PRP denotes We
T9189 2287-2297 RB denotes previously
T9190 2298-2306 VB denotes reported
T9191 2307-2311 IN denotes that
T9192 2312-2315 NN denotes Th1
T9193 2316-2320 NN denotes cell
T9194 2321-2336 NN denotes differentiation
T9195 2337-2340 VB denotes was
T9196 2341-2350 VB denotes regulated
T9197 2351-2358 IN denotes through
T9198 2359-2360 DT denotes a
T9199 2361-2373 JJ denotes feed-forward
T9200 2374-2378 NN denotes loop
T9201 2379-2381 IN denotes in
T9202 2382-2387 WDT denotes which
T9203 2388-2393 NN denotes T-bet
T9204 2394-2396 VB denotes is
T9205 2397-2409 VB denotes up-regulated
T9206 2410-2415 RB denotes early
T9207 2416-2419 CC denotes and
T9208 2420-2427 VB denotes induces
T9209 2428-2433 NN denotes Runx3
T9210 2433-2434 -COMMA- denotes ,
T9211 2435-2440 IN denotes after
T9212 2441-2446 WDT denotes which
T9213 2447-2452 NN denotes T-bet
T9214 2453-2456 CC denotes and
T9215 2457-2462 NN denotes Runx3
T9216 2463-2472 VB denotes cooperate
T9217 2473-2475 TO denotes to
T9218 2476-2482 VB denotes induce
T9219 2483-2488 NN denotes IFN-γ
T9220 2489-2492 CC denotes and
T9221 2493-2500 NN denotes silence
T9222 2501-2505 NN denotes IL-4
T9223 2505-2506 -COMMA- denotes ,
T9224 2507-2511 RB denotes thus
T9225 2512-2521 VB denotes promoting
T9226 2522-2528 JJ denotes stable
T9227 2529-2544 NN denotes differentiation
T9228 2545-2551 IN denotes toward
T9229 2552-2555 DT denotes the
T9230 2556-2559 NN denotes Th1
T9231 2560-2567 NN denotes lineage
T9232 2568-2569 -LRB- denotes (
T9233 2569-2571 CD denotes 15
T9234 2571-2572 -COMMA- denotes ,
T9235 2573-2575 CD denotes 22
T9236 2575-2576 -RRB- denotes )
T9237 2578-2585 IN denotes Because
T9238 2586-2587 -LRB- denotes (
T9239 2587-2588 DT denotes a
T9240 2588-2589 -RRB- denotes )
T9241 2590-2595 NN denotes Runx3
T9242 2596-2604 VB denotes appeared
T9243 2605-2614 JJ denotes necessary
T9244 2615-2618 IN denotes for
T9245 2619-2624 NN denotes Eomes
T9246 2625-2634 NN denotes induction
T9247 2635-2636 -LRB- denotes (
T9248 2636-2640 NN denotes Fig.
T9249 2641-2642 CD denotes 3
T9250 2643-2644 NN denotes A
T9251 2644-2645 -RRB- denotes )
T9252 2645-2646 -COMMA- denotes ,
T9253 2647-2648 -LRB- denotes (
T9254 2648-2649 NN denotes b
T9255 2649-2650 -RRB- denotes )
T9256 2651-2654 DT denotes the
T9257 2655-2663 NN denotes kinetics
T9258 2664-2666 IN denotes of
T9259 2667-2672 NN denotes Eomes
T9260 2673-2683 NN denotes expression
T9261 2684-2694 VB denotes paralleled
T9262 2695-2700 DT denotes those
T9263 2701-2703 IN denotes of
T9264 2704-2712 NN denotes perforin
T9265 2713-2723 NN denotes expression
T9266 2724-2725 -LRB- denotes (
T9267 2725-2729 NN denotes Fig.
T9268 2730-2731 CD denotes 2
T9269 2731-2732 -RRB- denotes )
T9270 2732-2733 -COMMA- denotes ,
T9271 2734-2737 CC denotes and
T9272 2738-2739 -LRB- denotes (
T9273 2739-2740 NN denotes c
T9274 2740-2741 -RRB- denotes )
T9275 2742-2756 NN denotes overexpression
T9276 2757-2759 IN denotes of
T9277 2760-2767 NN denotes Eo-VP16
T9278 2768-2770 IN denotes in
T9279 2771-2777 CC denotes either
T9280 2778-2780 NN denotes WT
T9281 2781-2783 CC denotes or
T9282 2784-2799 JJ denotes T-bet–deficient
T9283 2800-2801 NN denotes T
T9284 2802-2807 NN denotes cells
T9285 2808-2811 VB denotes led
T9286 2812-2814 TO denotes to
T9287 2815-2817 DT denotes an
T9288 2818-2826 NN denotes increase
T9289 2827-2829 IN denotes in
T9290 2830-2834 CC denotes both
T9291 2835-2843 NN denotes perforin
T9292 2844-2847 CC denotes and
T9293 2848-2853 NN denotes IFN-γ
T9294 2854-2864 NN denotes expression
T9295 2865-2866 -LRB- denotes (
T9296 2866-2870 NN denotes Fig.
T9297 2871-2872 CD denotes 2
T9298 2872-2873 -COMMA- denotes ,
T9299 2874-2875 NN denotes B
T9300 2876-2879 CC denotes and
T9301 2880-2881 NN denotes D
T9302 2881-2882 -RRB- denotes )
T9303 2882-2883 -COMMA- denotes ,
T9304 2884-2886 PRP denotes we
T9305 2887-2892 VB denotes asked
T9306 2893-2900 IN denotes whether
T9307 2901-2904 NN denotes CTL
T9308 2905-2920 NN denotes differentiation
T9309 2921-2924 VB denotes was
T9310 2925-2929 RB denotes also
T9311 2930-2941 RB denotes potentially
T9312 2942-2951 VB denotes regulated
T9313 2952-2954 IN denotes by
T9314 2955-2956 DT denotes a
T9315 2957-2969 JJ denotes feed-forward
T9316 2970-2974 NN denotes loop
T9317 2975-2984 VB denotes involving
T9318 2985-2990 DT denotes these
T9319 2991-2995 JJ denotes same
T9320 2996-2999 CD denotes two
T9321 3000-3007 NN denotes classes
T9322 3008-3010 IN denotes of
T9323 3011-3015 NN denotes Runx
T9324 3016-3019 CC denotes and
T9325 3020-3025 NN denotes T-box
T9326 3026-3039 NN denotes transcription
T9327 3040-3047 NN denotes factors
T9328 3049-3061 RB denotes Specifically
T9329 3061-3062 -COMMA- denotes ,
T9330 3063-3065 PRP denotes we
T9331 3066-3071 VB denotes asked
T9332 3072-3079 IN denotes whether
T9333 3080-3085 NN denotes Runx3
T9334 3085-3086 -COMMA- denotes ,
T9335 3087-3092 WDT denotes which
T9336 3093-3096 VB denotes was
T9337 3097-3106 JJ denotes necessary
T9338 3107-3110 IN denotes for
T9339 3111-3116 NN denotes Eomes
T9340 3117-3126 NN denotes induction
T9341 3126-3127 -COMMA- denotes ,
T9342 3128-3132 RB denotes then
T9343 3133-3143 VB denotes cooperated
T9344 3144-3148 IN denotes with
T9345 3149-3154 NN denotes Eomes
T9346 3155-3157 TO denotes to
T9347 3158-3166 VB denotes regulate
T9348 3167-3180 NN denotes transcription
T9349 3181-3183 IN denotes of
T9350 3184-3187 DT denotes the
T9351 3188-3196 NN denotes effector
T9352 3197-3200 NN denotes CTL
T9353 3201-3208 NN denotes markers
T9354 3209-3217 NN denotes perforin
T9355 3217-3218 -COMMA- denotes ,
T9356 3219-3224 NN denotes IFN-γ
T9357 3224-3225 -COMMA- denotes ,
T9358 3226-3229 CC denotes and
T9359 3230-3238 NN denotes granzyme
T9360 3239-3240 NN denotes B
T9361 3242-3244 TO denotes To
T9362 3245-3249 VB denotes test
T9363 3250-3254 DT denotes this
T9364 3255-3265 NN denotes hypothesis
T9365 3265-3266 -COMMA- denotes ,
T9366 3267-3269 PRP denotes we
T9367 3270-3274 VB denotes used
T9368 3275-3284 NN denotes chromatin
T9369 3285-3304 NN denotes immunoprecipitation
T9370 3305-3306 -LRB- denotes (
T9371 3306-3310 NN denotes ChIP
T9372 3310-3311 -RRB- denotes )
T9373 3312-3318 NN denotes assays
T9374 3319-3321 TO denotes to
T9375 3322-3325 VB denotes ask
T9376 3326-3333 IN denotes whether
T9377 3334-3339 NN denotes Eomes
T9378 3340-3343 CC denotes and
T9379 3344-3349 NN denotes Runx3
T9380 3350-3355 VB denotes bound
T9381 3356-3366 JJ denotes regulatory
T9382 3367-3374 NN denotes regions
T9383 3375-3377 IN denotes of
T9384 3378-3381 DT denotes the
T9385 3382-3386 NN denotes Prf1
T9386 3386-3387 -COMMA- denotes ,
T9387 3388-3392 NN denotes Ifng
T9388 3392-3393 -COMMA- denotes ,
T9389 3394-3397 CC denotes and
T9390 3398-3402 NN denotes Gzmb
T9391 3403-3408 NN denotes genes
T9392 3409-3410 -LRB- denotes (
T9393 3410-3414 NN denotes Fig.
T9394 3415-3416 CD denotes 3
T9395 3417-3418 NN denotes D
T9396 3418-3419 -RRB- denotes )
T9397 3421-3425 DT denotes Both
T9398 3426-3434 NN denotes proteins
T9399 3435-3445 VB denotes associated
T9400 3446-3450 IN denotes with
T9401 3451-3455 NN denotes gene
T9402 3456-3466 JJ denotes regulatory
T9403 3467-3474 NN denotes regions
T9404 3475-3477 IN denotes in
T9405 3478-3492 VB denotes differentiated
T9406 3493-3497 NN denotes CTLs
T9407 3499-3504 NN denotes Runx3
T9408 3505-3510 VB denotes bound
T9409 3511-3513 TO denotes to
T9410 3514-3517 DT denotes the
T9411 3518-3522 NN denotes Prf1
T9412 3523-3526 CC denotes and
T9413 3527-3531 NN denotes Gzmb
T9414 3532-3545 NN denotes transcription
T9415 3546-3551 NN denotes start
T9416 3552-3557 NN denotes sites
T9417 3558-3559 -LRB- denotes (
T9418 3559-3562 NN denotes TSS
T9419 3562-3563 -RRB- denotes )
T9420 3563-3564 -COLON- denotes ;
T9421 3565-3567 TO denotes to
T9422 3568-3569 DT denotes a
T9423 3570-3575 VB denotes known
T9424 3576-3580 NN denotes IL-2
T9425 3581-3591 JJ denotes responsive
T9426 3592-3600 NN denotes enhancer
T9427 3601-3608 JJ denotes located
T9428 3609-3613 IN denotes near
T9429 3614-3616 NN denotes −1
T9430 3617-3619 NN denotes kb
T9431 3620-3622 IN denotes of
T9432 3623-3626 DT denotes the
T9433 3627-3631 NN denotes Prf1
T9434 3632-3636 NN denotes gene
T9435 3637-3638 -LRB- denotes (
T9436 3638-3640 CD denotes 23
T9437 3640-3641 -RRB- denotes )
T9438 3641-3642 -COLON- denotes ;
T9439 3643-3645 TO denotes to
T9440 3646-3649 DT denotes the
T9441 3650-3656 JJ denotes distal
T9442 3657-3669 JJ denotes CTL-specific
T9443 3670-3675 NN denotes DNase
T9444 3676-3677 CD denotes I
T9445 3678-3692 JJ denotes hypersensitive
T9446 3693-3697 NN denotes site
T9447 3698-3699 CD denotes 9
T9448 3700-3702 IN denotes in
T9449 3703-3706 DT denotes the
T9450 3707-3711 NN denotes Prf1
T9451 3712-3717 NN denotes locus
T9452 3718-3719 -LRB- denotes (
T9453 3719-3721 CD denotes 24
T9454 3721-3722 -RRB- denotes )
T9455 3722-3723 -COLON- denotes ;
T9456 3724-3726 TO denotes to
T9457 3727-3730 DT denotes the
T9458 3731-3735 NN denotes Ifng
T9459 3736-3744 NN denotes promoter
T9460 3745-3749 IN denotes near
T9461 3750-3753 DT denotes the
T9462 3754-3757 NN denotes TSS
T9463 3757-3758 -COMMA- denotes ,
T9464 3759-3761 IN denotes as
T9465 3762-3772 RB denotes previously
T9466 3773-3781 VB denotes reported
T9467 3782-3785 IN denotes for
T9468 3786-3789 NN denotes Th1
T9469 3790-3795 NN denotes cells
T9470 3796-3797 -LRB- denotes (
T9471 3797-3799 CD denotes 10
T9472 3799-3800 -RRB- denotes )
T9473 3800-3801 -COLON- denotes ;
T9474 3802-3805 CC denotes and
T9475 3806-3808 TO denotes to
T9476 3809-3816 JJ denotes several
T9477 3817-3822 NN denotes DNase
T9478 3823-3824 CD denotes I
T9479 3825-3839 JJ denotes hypersensitive
T9480 3840-3845 NN denotes sites
T9481 3846-3848 IN denotes in
T9482 3849-3852 DT denotes the
T9483 3853-3857 NN denotes Ifng
T9484 3858-3863 NN denotes locus
T9485 3864-3865 -LRB- denotes (
T9486 3865-3869 NN denotes Fig.
T9487 3870-3871 CD denotes 3
T9488 3872-3873 NN denotes D
T9489 3874-3877 CC denotes and
T9490 3878-3881 RB denotes not
T9491 3882-3890 VB denotes depicted
T9492 3890-3891 -RRB- denotes )
T9493 3892-3893 -LRB- denotes (
T9494 3893-3895 CD denotes 25
T9495 3895-3896 -RRB- denotes )
T9496 3898-3903 NN denotes Eomes
T9497 3904-3909 VB denotes bound
T9498 3910-3919 RB denotes primarily
T9499 3920-3922 TO denotes to
T9500 3923-3926 DT denotes the
T9501 3927-3931 NN denotes Prf1
T9502 3932-3935 NN denotes TSS
T9503 3936-3939 CC denotes and
T9504 3940-3943 DT denotes the
T9505 3944-3946 NN denotes −1
T9506 3947-3949 NN denotes kb
T9507 3950-3958 NN denotes enhancer
T9508 3958-3959 -COLON- denotes ;
T9509 3960-3964 DT denotes this
T9510 3965-3972 NN denotes binding
T9511 3973-3976 VB denotes was
T9512 3977-3990 RB denotes substantially
T9513 3991-3998 JJ denotes greater
T9514 3999-4003 IN denotes than
T9515 4004-4008 DT denotes that
T9516 4009-4017 VB denotes observed
T9517 4018-4020 IN denotes at
T9518 4021-4024 DT denotes the
T9519 4025-4033 NN denotes promoter
T9520 4034-4036 IN denotes of
T9521 4037-4040 DT denotes the
T9522 4041-4046 NN denotes Il2rb
T9523 4047-4051 NN denotes gene
T9524 4051-4052 -COMMA- denotes ,
T9525 4053-4054 DT denotes a
T9526 4055-4060 JJ denotes known
T9527 4061-4067 JJ denotes direct
T9528 4068-4074 NN denotes target
T9529 4075-4077 IN denotes of
T9530 4078-4083 NN denotes Eomes
T9531 4084-4085 -LRB- denotes (
T9532 4085-4086 CD denotes 8
T9533 4086-4087 -RRB- denotes )
T9534 4087-4088 -COMMA- denotes ,
T9535 4089-4092 CC denotes and
T9536 4093-4103 JJ denotes comparable
T9537 4104-4106 TO denotes to
T9538 4107-4111 DT denotes that
T9539 4112-4120 VB denotes observed
T9540 4121-4123 IN denotes at
T9541 4124-4127 DT denotes the
T9542 4128-4132 NNP denotes Ifng
T9543 4133-4136 NN denotes TSS
T9544 4136-4137 -COMMA- denotes ,
T9545 4138-4139 DT denotes a
T9546 4140-4145 VB denotes known
T9547 4146-4152 NN denotes target
T9548 4153-4155 IN denotes of
T9549 4156-4161 NN denotes T-box
T9550 4162-4170 NN denotes proteins
T9551 4171-4173 IN denotes in
T9552 4174-4178 CC denotes both
T9553 4179-4182 NN denotes Th1
T9554 4183-4186 CC denotes and
T9555 4187-4191 JJ denotes CD8+
T9556 4192-4193 NN denotes T
T9557 4194-4199 NN denotes cells
T9558 4200-4201 -LRB- denotes (
T9559 4201-4205 NN denotes Fig.
T9560 4206-4207 CD denotes 3
T9561 4208-4209 NN denotes D
T9562 4209-4210 -RRB- denotes )
T9563 4211-4212 -LRB- denotes (
T9564 4212-4214 CD denotes 17
T9565 4214-4215 -RRB- denotes )
T9566 4217-4219 TO denotes To
T9567 4220-4229 VB denotes determine
T9568 4230-4237 IN denotes whether
T9569 4238-4243 NN denotes Runx3
T9570 4244-4254 VB denotes controlled
T9571 4255-4258 DT denotes the
T9572 4259-4269 NN denotes expression
T9573 4270-4272 IN denotes of
T9574 4273-4276 NN denotes CTL
T9575 4277-4285 NN denotes effector
T9576 4286-4291 NN denotes genes
T9577 4292-4299 IN denotes through
T9578 4300-4303 PRP-DOLLAR- denotes its
T9579 4304-4313 NN denotes induction
T9580 4314-4316 IN denotes of
T9581 4317-4322 NN denotes Eomes
T9582 4322-4323 -COMMA- denotes ,
T9583 4324-4326 PRP denotes we
T9584 4327-4339 RB denotes retrovirally
T9585 4340-4349 VB denotes expressed
T9586 4350-4355 NN denotes Runx3
T9587 4356-4359 CC denotes and
T9588 4360-4367 NN denotes Eo-VP16
T9589 4368-4370 IN denotes in
T9590 4371-4375 JJ denotes CD8+
T9591 4376-4377 NN denotes T
T9592 4378-4383 NN denotes cells
T9593 4384-4388 IN denotes from
T9594 4389-4397 NN denotes Runx3−/−
T9595 4398-4402 NN denotes mice
T9596 4404-4411 IN denotes Because
T9597 4412-4414 IN denotes of
T9598 4415-4418 DT denotes the
T9599 4419-4426 JJ denotes limited
T9600 4427-4433 NN denotes number
T9601 4434-4436 IN denotes of
T9602 4437-4441 JJ denotes CD8+
T9603 4442-4443 NN denotes T
T9604 4444-4449 NN denotes cells
T9605 4450-4452 IN denotes in
T9606 4453-4458 DT denotes these
T9607 4459-4463 NN denotes mice
T9608 4463-4464 -COMMA- denotes ,
T9609 4465-4468 CC denotes and
T9610 4469-4476 IN denotes because
T9611 4477-4479 PRP denotes we
T9612 4480-4483 VB denotes saw
T9613 4484-4486 DT denotes no
T9614 4487-4497 NN denotes difference
T9615 4498-4505 IN denotes between
T9616 4506-4514 NN denotes Runx3−/−
T9617 4515-4523 NN denotes CD8+CD4−
T9618 4524-4526 NN denotes SP
T9619 4527-4530 CC denotes and
T9620 4531-4539 JJ denotes CD8+CD4+
T9621 4540-4542 NN denotes DP
T9622 4543-4548 NN denotes cells
T9623 4549-4551 IN denotes in
T9624 4552-4555 PRP-DOLLAR- denotes our
T9625 4556-4564 JJ denotes previous
T9626 4565-4576 NN denotes experiments
T9627 4576-4577 -COMMA- denotes ,
T9628 4578-4580 PRP denotes we
T9629 4581-4585 VB denotes used
T9630 4586-4591 JJ denotes total
T9631 4592-4600 NN denotes Runx3−/−
T9632 4601-4605 JJ denotes CD8+
T9633 4606-4607 NN denotes T
T9634 4608-4613 NN denotes cells
T9635 4614-4621 IN denotes without
T9636 4622-4629 JJ denotes further
T9637 4630-4643 NN denotes fractionation
T9638 4644-4646 IN denotes as
T9639 4647-4657 NN denotes recipients
T9640 4658-4661 IN denotes for
T9641 4662-4672 JJ denotes retroviral
T9642 4673-4685 NN denotes transduction
T9643 4687-4701 NN denotes Reconstitution
T9644 4702-4704 IN denotes of
T9645 4705-4713 NN denotes Runx3−/−
T9646 4714-4718 JJ denotes CD8+
T9647 4719-4720 NN denotes T
T9648 4721-4726 NN denotes cells
T9649 4727-4731 IN denotes with
T9650 4732-4737 NN denotes Runx3
T9651 4738-4746 VB denotes restored
T9652 4747-4757 NN denotes expression
T9653 4758-4760 IN denotes of
T9654 4761-4766 NN denotes Eomes
T9655 4767-4769 RB denotes as
T9656 4770-4774 RB denotes well
T9657 4775-4777 IN denotes as
T9658 4778-4786 NN denotes perforin
T9659 4786-4787 -COMMA- denotes ,
T9660 4788-4796 NN denotes granzyme
T9661 4797-4798 NN denotes B
T9662 4798-4799 -COMMA- denotes ,
T9663 4800-4803 CC denotes and
T9664 4804-4809 NN denotes IFN-γ
T9665 4810-4811 -LRB- denotes (
T9666 4811-4815 NN denotes Fig.
T9667 4816-4817 CD denotes 4
T9668 4817-4818 -COMMA- denotes ,
T9669 4819-4820 NN denotes A
T9670 4821-4824 CC denotes and
T9671 4825-4826 NN denotes B
T9672 4826-4827 -RRB- denotes )
T9673 4829-4831 IN denotes In
T9674 4832-4840 NN denotes addition
T9675 4840-4841 -COMMA- denotes ,
T9676 4842-4850 NN denotes Runx3−/−
T9677 4851-4852 NN denotes T
T9678 4853-4858 NN denotes cells
T9679 4859-4865 VB denotes showed
T9680 4866-4867 DT denotes a
T9681 4868-4880 JJ denotes compensatory
T9682 4881-4894 NN denotes up-regulation
T9683 4895-4897 IN denotes of
T9684 4898-4903 NN denotes Runx1
T9685 4903-4904 -COMMA- denotes ,
T9686 4905-4910 WDT denotes which
T9687 4911-4914 VB denotes was
T9688 4915-4925 VB denotes suppressed
T9689 4926-4930 IN denotes upon
T9690 4931-4945 NN denotes reconstitution
T9691 4946-4950 IN denotes with
T9692 4951-4956 NN denotes Runx3
T9693 4956-4957 -COMMA- denotes ,
T9694 4958-4968 VB denotes indicating
T9695 4969-4973 IN denotes that
T9696 4974-4979 NN denotes Runx1
T9697 4980-4982 VB denotes is
T9698 4983-4984 DT denotes a
T9699 4985-4991 NN denotes target
T9700 4992-4994 IN denotes of
T9701 4995-5005 NN denotes repression
T9702 5006-5008 IN denotes by
T9703 5009-5014 NN denotes Runx3
T9704 5016-5023 RB denotes Notably
T9705 5023-5024 -COMMA- denotes ,
T9706 5025-5032 NN denotes Eo-VP16
T9707 5033-5036 VB denotes did
T9708 5037-5040 RB denotes not
T9709 5041-5052 VB denotes up-regulate
T9710 5053-5061 NN denotes perforin
T9711 5062-5072 NN denotes expression
T9712 5073-5077 WRB denotes when
T9713 5078-5087 VB denotes expressed
T9714 5088-5090 IN denotes in
T9715 5091-5099 NN denotes Runx3−/−
T9716 5100-5105 NN denotes cells
T9717 5105-5106 -COMMA- denotes ,
T9718 5107-5111 RB denotes even
T9719 5112-5118 IN denotes though
T9720 5119-5121 PRP denotes it
T9721 5122-5130 VB denotes restored
T9722 5131-5134 DT denotes the
T9723 5135-5143 NN denotes capacity
T9724 5144-5146 TO denotes to
T9725 5147-5153 VB denotes induce
T9726 5154-5159 NN denotes IFN-γ
T9727 5160-5170 NN denotes expression
T9728 5171-5175 IN denotes upon
T9729 5176-5179 NN denotes TCR
T9730 5180-5193 NN denotes restimulation
T9731 5194-5195 -LRB- denotes (
T9732 5195-5199 NN denotes Fig.
T9733 5200-5201 CD denotes 4
T9734 5201-5202 -COMMA- denotes ,
T9735 5203-5204 NN denotes A
T9736 5205-5208 CC denotes and
T9737 5209-5210 NN denotes B
T9738 5210-5211 -RRB- denotes )
T9739 5213-5217 DT denotes This
T9740 5218-5224 NN denotes result
T9741 5225-5233 VB denotes suggests
T9742 5234-5242 RB denotes strongly
T9743 5243-5247 IN denotes that
T9744 5248-5256 NN denotes perforin
T9745 5257-5267 NN denotes expression
T9746 5268-5276 VB denotes requires
T9747 5277-5282 NN denotes Runx3
T9748 5283-5286 CC denotes and
T9749 5287-5292 NN denotes Eomes
T9750 6965-6967 IN denotes As
T9751 6968-6976 VB denotes expected
T9752 6977-6981 IN denotes from
T9753 6982-6987 PRP-DOLLAR- denotes their
T9754 6988-6994 NN denotes defect
T9755 6995-6997 IN denotes in
T9756 6998-7006 NN denotes perforin
T9757 7007-7010 CC denotes and
T9758 7011-7019 NN denotes granzyme
T9759 7020-7021 NN denotes B
T9760 7022-7032 NN denotes expression
T9761 7032-7033 -COMMA- denotes ,
T9762 7034-7042 NN denotes Runx3−/−
T9763 7043-7047 JJ denotes CD8+
T9764 7048-7049 NN denotes T
T9765 7050-7055 NN denotes cells
T9766 7056-7062 VB denotes showed
T9767 7063-7072 JJ denotes defective
T9768 7073-7082 JJ denotes cytolytic
T9769 7083-7091 NN denotes activity
T9770 7092-7094 IN denotes in
T9771 7095-7096 DT denotes a
T9772 7097-7102 JJ denotes mixed
T9773 7103-7113 NN denotes lymphocyte
T9774 7114-7122 NN denotes reaction
T9775 7123-7124 -LRB- denotes (
T9776 7124-7126 CD denotes 12
T9777 7126-7127 -RRB- denotes )
T9778 7129-7136 RB denotes However
T9779 7136-7137 -COMMA- denotes ,
T9780 7138-7152 JJ denotes TCR-stimulated
T9781 7153-7161 NN denotes Runx3−/−
T9782 7162-7166 JJ denotes CD8+
T9783 7167-7172 NN denotes cells
T9784 7173-7177 VB denotes were
T9785 7178-7180 RB denotes as
T9786 7181-7190 JJ denotes effective
T9787 7191-7193 IN denotes as
T9788 7194-7196 JJ denotes WT
T9789 7197-7202 NN denotes cells
T9790 7203-7205 IN denotes in
T9791 7206-7213 VB denotes killing
T9792 7214-7219 NN denotes tumor
T9793 7220-7225 NN denotes cells
T9794 7226-7228 IN denotes in
T9795 7229-7230 DT denotes a
T9796 7231-7241 JJ denotes redirected
T9797 7242-7245 NN denotes CTL
T9798 7246-7251 NN denotes assay
T9799 7252-7253 -LRB- denotes (
T9800 7253-7255 CD denotes 12
T9801 7255-7256 -RRB- denotes )
T9802 7258-7269 RB denotes Furthermore
T9803 7269-7270 -COMMA- denotes ,
T9804 7271-7275 JJ denotes CD8+
T9805 7276-7281 NN denotes cells
T9806 7282-7286 IN denotes from
T9807 7287-7290 DT denotes the
T9808 7291-7301 JJ denotes peritoneal
T9809 7302-7308 NN denotes cavity
T9810 7309-7311 IN denotes of
T9811 7312-7320 NN denotes Runx3−/−
T9812 7321-7325 NN denotes mice
T9813 7326-7335 VB denotes immunized
T9814 7336-7340 IN denotes with
T9815 7341-7348 JJ denotes certain
T9816 7349-7354 NN denotes tumor
T9817 7355-7360 NN denotes cells
T9818 7361-7372 RB denotes effectively
T9819 7373-7379 VB denotes killed
T9820 7380-7385 DT denotes these
T9821 7386-7393 NN denotes targets
T9822 7394-7395 -LRB- denotes (
T9823 7395-7397 CD denotes 13
T9824 7397-7398 -RRB- denotes )
T9825 7400-7409 RB denotes Therefore
T9826 7409-7410 -COMMA- denotes ,
T9827 7411-7419 IN denotes although
T9828 7420-7430 NN denotes activation
T9829 7431-7433 IN denotes of
T9830 7434-7437 DT denotes the
T9831 7438-7455 NN denotes perforin/granzyme
T9832 7456-7457 NN denotes B
T9833 7458-7467 NN denotes machinery
T9834 7468-7470 VB denotes is
T9835 7471-7480 JJ denotes defective
T9836 7481-7483 IN denotes in
T9837 7484-7492 NN denotes Runx3−/−
T9838 7493-7497 JJ denotes CD8+
T9839 7498-7503 NN denotes cells
T9840 7503-7504 -COMMA- denotes ,
T9841 7505-7510 DT denotes these
T9842 7511-7516 NN denotes cells
T9843 7517-7520 VB denotes are
T9844 7521-7524 RB denotes not
T9845 7525-7533 RB denotes entirely
T9846 7534-7540 JJ denotes devoid
T9847 7541-7543 IN denotes of
T9848 7544-7553 JJ denotes cytolytic
T9849 7554-7562 NN denotes activity
T9850 7563-7566 CC denotes and
T9851 7567-7572 MD denotes could
T9852 7573-7578 RB denotes still
T9853 7579-7590 RB denotes effectively
T9854 7591-7595 VB denotes kill
T9855 7596-7603 NN denotes targets
T9856 7603-7604 -COMMA- denotes ,
T9857 7605-7613 RB denotes possibly
T9858 7614-7616 IN denotes by
T9859 7617-7628 JJ denotes alternative
T9860 7629-7639 NN denotes mechanisms
T9861 7640-7644 JJ denotes such
T9862 7645-7647 IN denotes as
T9863 7648-7651 DT denotes the
T9864 7652-7659 NN denotes Fas–Fas
T9865 7660-7666 NN denotes ligand
T9866 7667-7674 NN denotes pathway
T21280 5304-5309 NN denotes Runx3
T21281 5310-5318 VB denotes controls
T21282 5319-5324 NN denotes Eomes
T21283 5324-5325 -COMMA- denotes ,
T21284 5326-5334 NN denotes perforin
T21285 5334-5335 -COMMA- denotes ,
T21286 5336-5344 NN denotes granzyme
T21287 5345-5346 NN denotes B
T21288 5346-5347 -COMMA- denotes ,
T21289 5348-5351 CC denotes and
T21290 5352-5357 NN denotes IFN-γ
T21291 5358-5368 NN denotes expression
T21292 5369-5371 IN denotes in
T21293 5372-5380 NN denotes effector
T21294 5381-5385 NN denotes CTLs
T21295 5387-5395 NN denotes Runx3+/+
T21296 5396-5398 CC denotes or
T21297 5399-5407 NN denotes Runx3−/−
T21298 5408-5412 JJ denotes CD8+
T21299 5413-5414 NN denotes T
T21300 5415-5420 NN denotes cells
T21301 5421-5425 VB denotes were
T21302 5426-5435 VB denotes activated
T21303 5436-5439 CC denotes and
T21304 5440-5450 VB denotes transduced
T21305 5451-5455 IN denotes with
T21306 5456-5468 NN denotes retroviruses
T21307 5469-5476 VB denotes bearing
T21308 5477-5479 DT denotes an
T21309 5480-5485 JJ denotes empty
T21310 5486-5494 NN denotes IRES-GFP
T21311 5495-5503 NN denotes cassette
T21312 5504-5505 -LRB- denotes (
T21313 5505-5508 NN denotes GFP
T21314 5508-5509 -RRB- denotes )
T21315 5510-5512 CC denotes or
T21316 5513-5517 RB denotes also
T21317 5518-5526 VB denotes encoding
T21318 5527-5537 NN denotes Eomes-VP16
T21319 5538-5539 -LRB- denotes (
T21320 5539-5546 NN denotes Eo-VP16
T21321 5546-5547 -RRB- denotes )
T21322 5548-5550 CC denotes or
T21323 5551-5560 NN denotes Myc-Runx3
T21324 5561-5562 -LRB- denotes (
T21325 5562-5567 NN denotes Runx3
T21326 5567-5568 -RRB- denotes )
T21327 5570-5573 DT denotes The
T21328 5574-5583 NN denotes frequency
T21329 5584-5586 IN denotes of
T21330 5587-5597 VB denotes transduced
T21331 5598-5603 NN denotes cells
T21332 5604-5606 IN denotes in
T21333 5607-5610 DT denotes the
T21334 5611-5619 NN denotes cultures
T21335 5620-5623 VB denotes was
T21336 5624-5634 JJ denotes equivalent
T21337 5635-5638 IN denotes for
T21338 5639-5642 DT denotes all
T21339 5643-5653 NN denotes constructs
T21340 5654-5655 -LRB- denotes (
T21341 5655-5661 CD denotes ∼75–90
T21342 5661-5662 NN denotes %
T21343 5663-5667 NN denotes GFP+
T21344 5668-5673 NN denotes cells
T21345 5673-5674 -COLON- denotes ;
T21346 5675-5678 RB denotes not
T21347 5679-5687 VB denotes depicted
T21348 5687-5688 -RRB- denotes )
T21349 5688-5689 -LRB- denotes .
T21350 5690-5691 NN denotes (
T21351 5691-5692 -RRB- denotes A
T21352 5692-5699 NN denotes ) Prote
T21353 5699-5709 NN denotes in express
T21354 5709-5711 IN denotes io
T21355 5711-5721 JJ denotes n in whole
T21356 5721-5729 NN denotes -cell ex
T21357 5729-5730 -LRB- denotes t
T21358 5730-5733 NN denotes rac
T21359 5733-5734 CD denotes t
T21360 5734-5735 -RRB- denotes s
T21361 5736-5739 VB denotes (da
T21362 5739-5747 VB denotes y 6) was
T21363 5748-5750 IN denotes an
T21364 5750-5764 NN denotes alyzed by immu
T21365 5776-5790 NN denotes Overexpression
T21366 5791-5793 IN denotes of
T21367 5794-5804 NN denotes Eomes-VP16
T21368 5805-5808 MD denotes can
T21369 5808-5811 RB denotes not
T21370 5812-5814 VB denotes be
T21371 5815-5823 VB denotes detected
T21372 5824-5828 IN denotes with
T21373 5829-5832 DT denotes the
T21374 5833-5838 NN denotes Eomes
T21375 5839-5847 NN denotes antibody
T21376 5847-5848 -COMMA- denotes ,
T21377 5849-5851 IN denotes as
T21378 5852-5855 DT denotes the
T21379 5856-5866 JJ denotes C-terminal
T21380 5867-5874 NN denotes epitope
T21381 5875-5877 VB denotes is
T21382 5878-5884 IN denotes within
T21383 5885-5888 DT denotes the
T21384 5889-5895 NN denotes region
T21385 5896-5900 WDT denotes that
T21386 5901-5904 VB denotes has
T21387 5905-5909 VB denotes been
T21388 5910-5918 VB denotes replaced
T21389 5919-5923 IN denotes with
T21390 5924-5927 DT denotes the
T21391 5928-5932 NN denotes VP16
T21392 5933-5948 NN denotes transactivation
T21393 5949-5956 NN denotes domain.
T21394 5957-5958 -LRB- denotes (
T21395 5958-5959 NN denotes B
T21396 5959-5960 -RRB- denotes )
T21397 5961-5971 NN denotes Expression
T21398 5972-5974 IN denotes of
T21399 5975-5983 NN denotes granzyme
T21400 5984-5985 NN denotes B
T21401 5986-5989 CC denotes and
T21402 5990-5995 NN denotes IFN-γ
T21403 5996-6001 IN denotes after
T21404 6002-6009 NN denotes culture
T21405 6010-6013 IN denotes for
T21406 6014-6015 CD denotes 6
T21407 6016-6017 NN denotes d
T21408 6018-6021 CC denotes and
T21409 6022-6035 NN denotes restimulation
T21410 6036-6039 IN denotes for
T21411 6040-6041 CD denotes 4
T21412 6042-6043 NN denotes h
T21413 6044-6048 IN denotes with
T21414 6049-6052 NN denotes PMA
T21415 6053-6056 CC denotes and
T21416 6057-6066 NN denotes ionomycin
T21417 6067-6070 VB denotes was
T21418 6071-6081 VB denotes determined
T21419 6082-6084 IN denotes by
T21420 6085-6098 JJ denotes intracellular
T21421 6099-6107 NN denotes staining
T21422 6109-6112 DT denotes The
T21423 6113-6123 NN denotes percentage
T21424 6124-6126 IN denotes of
T21425 6127-6137 RB denotes positively
T21426 6138-6145 VB denotes stained
T21427 6146-6151 NN denotes cells
T21428 6152-6154 VB denotes is
T21429 6155-6160 VB denotes shown
T21430 6161-6166 IN denotes above
T21431 6167-6170 DT denotes the
T21432 6171-6175 NN denotes gate
T21433 6175-6176 -COLON- denotes ;
T21434 6177-6180 DT denotes the
T21435 6181-6185 JJ denotes mean
T21436 6186-6198 NN denotes fluorescence
T21437 6199-6208 NN denotes intensity
T21438 6209-6210 -LRB- denotes (
T21439 6210-6213 NN denotes MFI
T21440 6213-6214 -RRB- denotes )
T21441 6215-6217 IN denotes of
T21442 6218-6226 NN denotes granzyme
T21443 6227-6228 NN denotes B
T21444 6229-6237 NN denotes staining
T21445 6238-6241 IN denotes for
T21446 6242-6245 DT denotes the
T21447 6246-6251 JJ denotes total
T21448 6252-6262 NN denotes population
T21449 6263-6265 VB denotes is
T21450 6266-6271 VB denotes shown
T21451 6272-6277 IN denotes below
T21452 6278-6281 DT denotes the
T21453 6282-6286 NN denotes gate
T21454 6288-6291 DT denotes The
T21455 6292-6300 JJ denotes vertical
T21456 6301-6305 JJ denotes gray
T21457 6306-6311 NN denotes lines
T21458 6312-6320 VB denotes indicate
T21459 6321-6324 DT denotes the
T21460 6325-6328 NN denotes MFI
T21461 6329-6332 IN denotes for
T21462 6333-6335 JJ denotes WT
T21463 6336-6340 NN denotes GFP+
T21464 6341-6346 NN denotes cells
T21465 6348-6355 NN denotes Results
T21466 6356-6359 VB denotes are
T21467 6360-6374 JJ denotes representative
T21468 6375-6377 IN denotes of
T21469 6378-6380 IN denotes at
T21470 6381-6386 JJ denotes least
T21471 6387-6390 CD denotes two
T21472 6391-6402 JJ denotes independent
T21473 6403-6415 NN denotes experiments.
T21474 6416-6417 -LRB- denotes (
T21475 6417-6418 NN denotes C
T21476 6418-6419 -RRB- denotes )
T21477 6420-6429 JJ denotes Schematic
T21478 6430-6437 NN denotes diagram
T21479 6438-6440 IN denotes of
T21480 6441-6444 DT denotes the
T21481 6445-6460 JJ denotes transcriptional
T21482 6461-6468 NN denotes network
T21483 6469-6478 VB denotes involving
T21484 6479-6484 NN denotes Runx3
T21485 6485-6488 CC denotes and
T21486 6489-6494 NN denotes T-box
T21487 6495-6502 NN denotes factors
T21488 6504-6509 NN denotes T-bet
T21489 6510-6512 VB denotes is
T21490 6513-6520 VB denotes induced
T21491 6521-6523 IN denotes by
T21492 6524-6527 NN denotes TCR
T21493 6528-6535 NN denotes signals
T21494 6536-6539 CC denotes and
T21495 6540-6542 VB denotes is
T21496 6543-6552 JJ denotes essential
T21497 6553-6556 IN denotes for
T21498 6557-6562 JJ denotes early
T21499 6563-6568 NN denotes IFN-γ
T21500 6569-6579 NN denotes expression
T21501 6581-6586 NN denotes Runx3
T21502 6587-6589 VB denotes is
T21503 6590-6597 JJ denotes present
T21504 6598-6600 IN denotes in
T21505 6601-6606 JJ denotes naive
T21506 6607-6611 JJ denotes CD8+
T21507 6612-6613 NN denotes T
T21508 6614-6619 NN denotes cells
T21509 6620-6623 CC denotes and
T21510 6624-6633 VB denotes represses
T21511 6634-6639 NN denotes Runx1
T21512 6640-6643 CC denotes and
T21513 6644-6651 VB denotes induces
T21514 6652-6657 NN denotes Eomes
T21515 6657-6658 -COMMA- denotes ,
T21516 6659-6667 NN denotes perforin
T21517 6667-6668 -COMMA- denotes ,
T21518 6669-6677 NN denotes granzyme
T21519 6678-6679 NN denotes B
T21520 6679-6680 -COMMA- denotes ,
T21521 6681-6684 CC denotes and
T21522 6685-6690 NN denotes IFN-γ
T21523 6691-6701 NN denotes expression
T21524 6703-6708 NN denotes Eomes
T21525 6709-6712 MD denotes may
T21526 6713-6724 VB denotes participate
T21527 6725-6727 IN denotes in
T21528 6728-6738 VB denotes sustaining
T21529 6739-6743 JJ denotes late
T21530 6744-6749 NN denotes IFN-γ
T21531 6750-6760 NN denotes expression
T21532 6760-6761 -COMMA- denotes ,
T21533 6762-6769 IN denotes whereas
T21534 6770-6775 NN denotes Runx3
T21535 6776-6779 CC denotes and
T21536 6780-6785 NN denotes Eomes
T21537 6786-6787 -LRB- denotes (
T21538 6787-6790 CC denotes but
T21539 6791-6794 RB denotes not
T21540 6795-6800 NN denotes T-bet
T21541 6800-6801 -RRB- denotes )
T21542 6802-6805 MD denotes may
T21543 6806-6815 VB denotes cooperate
T21544 6816-6818 TO denotes to
T21545 6819-6827 VB denotes activate
T21546 6828-6836 NN denotes perforin
T21547 6837-6847 NN denotes expression
T21548 6849-6852 DT denotes The
T21549 6853-6859 JJ denotes dotted
T21550 6860-6864 NN denotes line
T21551 6865-6874 VB denotes indicates
T21552 6875-6878 DT denotes the
T21553 6879-6886 JJ denotes partial
T21554 6887-6893 NN denotes effect
T21555 6894-6896 IN denotes of
T21556 6897-6902 JJ denotes T-bet
T21557 6903-6913 NN denotes deficiency
T21558 6914-6916 IN denotes on
T21559 6917-6921 NN denotes Gzmb
T21560 6922-6926 NN denotes mRNA
T21561 6927-6930 CC denotes but
T21562 6931-6934 RB denotes not
T21563 6935-6943 NN denotes granzyme
T21564 6944-6945 NN denotes B
T21565 6946-6953 NN denotes protein
T21566 6954-6964 NN denotes expression
R7154 T8977 T8978 arg1Of Runx3,controls
R7155 T8980 T8978 arg2Of aspects,controls
R7156 T8980 T8979 arg1Of aspects,multiple
R7157 T8980 T8981 arg1Of aspects,of
R7158 T8980 T8986 arg1Of aspects,","
R7159 T8980 T8989 arg1Of aspects,through
R7160 T8985 T8981 arg2Of program,of
R7161 T8985 T8982 arg1Of program,the
R7162 T8985 T8983 arg1Of program,CTL
R7163 T8985 T8984 arg1Of program,differentiation
R7164 T8988 T8987 arg2Of part,in
R7165 T8989 T8987 arg1Of through,in
R7166 T8990 T8989 arg2Of induction,through
R7167 T8990 T8991 arg1Of induction,of
R7168 T8992 T8991 arg2Of Eomes,of
R7169 T8994 T8995 arg1Of Runx3,is
R7170 T8994 T8997 arg2Of Runx3,expressed
R7171 T8997 T8993 arg2Of expressed,Because
R7172 T8997 T8995 arg2Of expressed,is
R7173 T8997 T8996 arg1Of expressed,highly
R7174 T8997 T8998 arg1Of expressed,in
R7175 T8997 T9005 arg1Of expressed,because
R7176 T8998 T9004 arg1Of in,and
R7177 T9002 T8998 arg2Of cells,in
R7178 T9002 T8999 arg1Of cells,peripheral
R7179 T9002 T9000 arg1Of cells,CD8+
R7180 T9002 T9001 arg1Of cells,T
R7181 T9004 T9003 arg1Of and,","
R7182 T9005 T9004 arg2Of because,and
R7183 T9005 T9006 arg1Of because,of
R7184 T9009 T9005 arg2Of cooperation,because
R7185 T9009 T9007 arg1Of cooperation,the
R7186 T9009 T9008 arg1Of cooperation,T-bet-Runx3
R7187 T9009 T9011 arg2Of cooperation,observed
R7188 T9010 T9011 arg1Of we,observed
R7189 T9011 T9012 arg1Of observed,earlier
R7190 T9012 T9013 arg1Of earlier,in
R7191 T9016 T9013 arg2Of cells,in
R7192 T9016 T9014 arg1Of cells,CD4+
R7193 T9016 T9015 arg1Of cells,T
R7194 T9016 T9017 arg1Of cells,(
R7195 T9018 T9017 arg2Of 15,(
R7196 T9019 T9017 arg3Of ),(
R7197 T9021 T9022 arg1Of we,examined
R7198 T9022 T8993 arg1Of examined,Because
R7199 T9022 T9020 arg1Of examined,","
R7200 T9024 T9022 arg2Of role,examined
R7201 T9024 T9023 arg1Of role,the
R7202 T9024 T9025 arg1Of role,of
R7203 T9024 T9027 arg1Of role,in
R7204 T9026 T9025 arg2Of Runx3,of
R7205 T9030 T9027 arg2Of differentiation,in
R7206 T9030 T9028 arg1Of differentiation,effector
R7207 T9030 T9029 arg1Of differentiation,CTL
R7208 T9031 T9032 arg1Of We,isolated
R7209 T9032 T9052 arg1Of isolated,by
R7210 T9035 T9033 arg1Of cells,CD8+
R7211 T9035 T9034 arg1Of cells,T
R7212 T9035 T9036 arg1Of cells,from
R7213 T9035 T9047 arg1Of cells,and
R7214 T9039 T9038 arg2Of KO,(
R7215 T9040 T9038 arg3Of ),(
R7216 T9041 T9036 arg2Of mice,from
R7217 T9041 T9037 arg1Of mice,Runx3−/−
R7218 T9041 T9038 arg1Of mice,(
R7219 T9041 T9042 arg1Of mice,of
R7220 T9046 T9042 arg2Of background,of
R7221 T9046 T9043 arg1Of background,the
R7222 T9046 T9044 arg1Of background,outbred
R7223 T9046 T9045 arg1Of background,ICR
R7224 T9047 T9032 arg2Of and,isolated
R7225 T9051 T9047 arg2Of littermates,and
R7226 T9051 T9048 arg1Of littermates,their
R7227 T9051 T9049 arg1Of littermates,WT
R7228 T9051 T9050 arg1Of littermates,Runx3+/+
R7229 T9054 T9052 arg2Of selection,by
R7230 T9054 T9053 arg1Of selection,positive
R7231 T9054 T9055 arg1Of selection,with
R7232 T9058 T9055 arg2Of beads,with
R7233 T9058 T9056 arg1Of beads,anti-CD8
R7234 T9058 T9057 arg1Of beads,magnetic
R7235 T9058 T9059 arg1Of beads,(
R7236 T9061 T9062 arg1Of S1,and
R7237 T9062 T9059 arg2Of and,(
R7238 T9062 T9060 arg1Of and,Figs.
R7239 T9062 T9064 arg1Of and,","
R7240 T9062 T9065 arg1Of and,available
R7241 T9062 T9068 arg1Of and,:
R7242 T9063 T9062 arg2Of S2,and
R7243 T9065 T9066 arg1Of available,at
R7244 T9067 T9066 arg2Of http,at
R7245 T9069 T9068 arg2Of //www.jem.org/cgi/content/full/jem.20081242/DC1,:
R7246 T9070 T9059 arg3Of ),(
R7247 T9076 T9073 arg1Of cells,Runx3−/−
R7248 T9076 T9074 arg1Of cells,CD8+
R7249 T9076 T9075 arg1Of cells,T
R7250 T9076 T9077 arg1Of cells,were
R7251 T9076 T9079 arg1Of cells,impaired
R7252 T9077 T9071 arg1Of were,Strikingly
R7253 T9077 T9072 arg1Of were,","
R7254 T9077 T9088 arg1Of were,","
R7255 T9079 T9077 arg2Of impaired,were
R7256 T9079 T9078 arg1Of impaired,strongly
R7257 T9079 T9080 arg1Of impaired,in
R7258 T9082 T9080 arg2Of ability,in
R7259 T9082 T9081 arg1Of ability,their
R7260 T9082 T9083 modOf ability,to
R7261 T9084 T9083 arg1Of differentiate,to
R7262 T9084 T9085 arg1Of differentiate,into
R7263 T9087 T9085 arg2Of CTLs,into
R7264 T9087 T9086 arg1Of CTLs,effector
R7265 T9089 T9077 arg3Of as,were
R7266 T9090 T9089 arg2Of judged,as
R7267 T9092 T9090 arg1Of expression,judged
R7268 T9092 T9091 arg2Of expression,by
R7269 T9092 T9093 arg1Of expression,of
R7270 T9094 T9095 arg1Of perforin,","
R7271 T9095 T9099 arg1Of ",",and
R7272 T9097 T9095 arg2Of B,","
R7273 T9097 T9096 arg1Of B,granzyme
R7274 T9099 T9093 arg2Of and,of
R7275 T9099 T9098 arg1Of and,","
R7276 T9100 T9099 arg2Of IFN-γ,and
R7277 T9100 T9101 arg1Of IFN-γ,(
R7278 T9102 T9101 arg2Of Fig.,(
R7279 T9102 T9103 arg1Of Fig.,3
R7280 T9104 T9101 arg3Of ),(
R7281 T9106 T9105 arg2Of with,Compared
R7282 T9109 T9106 arg2Of cells,with
R7283 T9135 T9128 arg3Of ),(
R7284 T9109 T9107 arg1Of cells,WT
R7285 T9109 T9108 arg1Of cells,T
R7286 T9138 T9136 arg1Of cells,Runx3−/−
R7287 T9138 T9137 arg1Of cells,T
R7288 T9138 T9140 arg1Of cells,had
R7289 T9112 T9113 arg1Of mRNA,and
R7290 T9140 T9139 arg1Of had,also
R7291 T9140 T9145 arg1Of had,;
R7292 T9143 T9141 arg1Of Eomes,no
R7293 T9143 T9142 arg1Of Eomes,detectable
R7294 T9144 T9140 arg2Of expression,had
R7295 T9144 T9143 arg1Of expression,Eomes
R7296 T9114 T9113 arg2Of protein,and
R7297 T9147 T9146 arg2Of contrast,in
R7298 T9115 T9111 arg1Of expression,perforin
R7299 T9150 T9149 arg1Of expression,T-bet
R7300 T9150 T9151 arg1Of expression,was
R7301 T9150 T9152 arg1Of expression,unimpaired
R7302 T9151 T9145 arg2Of was,;
R7303 T9151 T9146 arg1Of was,in
R7304 T9151 T9148 arg1Of was,","
R7305 T9152 T9151 arg2Of unimpaired,was
R7306 T9152 T9153 arg1Of unimpaired,(
R7307 T9115 T9112 arg1Of expression,mRNA
R7308 T9115 T9114 arg1Of expression,protein
R7309 T9115 T9116 arg1Of expression,were
R7310 T9115 T9118 arg1Of expression,undetectable
R7311 T9156 T9153 arg2Of A,(
R7312 T9156 T9154 arg1Of A,Fig.
R7313 T9156 T9155 arg1Of A,3
R7314 T9157 T9153 arg3Of ),(
R7315 T9116 T9105 arg1Of were,Compared
R7316 T9160 T9161 arg1Of Runx3,was
R7317 T9160 T9162 arg2Of Runx3,required
R7318 T9162 T9158 arg1Of required,Furthermore
R7319 T9162 T9159 arg1Of required,","
R7320 T9162 T9161 arg2Of required,was
R7321 T9162 T9163 arg1Of required,for
R7322 T9162 T9174 arg1Of required,","
R7323 T9162 T9175 arg1Of required,by
R7324 T9116 T9110 arg1Of were,","
R7325 T9165 T9163 arg2Of production,for
R7326 T9165 T9164 arg1Of production,maximal
R7327 T9165 T9166 arg1Of production,of
R7328 T9118 T9116 arg2Of undetectable,were
R7329 T9167 T9169 arg1Of IFN-γ,but
R7330 T9169 T9166 arg2Of but,of
R7331 T9169 T9168 arg1Of but,","
R7332 T9169 T9170 arg1Of but,not
R7333 T9171 T9172 arg1Of TNF,or
R7334 T9118 T9117 arg1Of undetectable,essentially
R7335 T9172 T9169 arg2Of or,but
R7336 T9173 T9172 arg2Of IL-2,or
R7337 T9118 T9119 arg1Of undetectable,in
R7338 T9122 T9119 arg2Of cells,in
R7339 T9178 T9175 arg2Of cells,by
R7340 T9178 T9176 arg1Of cells,CD8+
R7341 T9178 T9177 arg1Of cells,T
R7342 T9178 T9179 arg2Of cells,restimulated
R7343 T9179 T9180 arg1Of restimulated,at
R7344 T9122 T9120 arg1Of cells,Runx3−/−
R7345 T9181 T9180 arg2Of day,at
R7346 T9181 T9182 arg1Of day,6
R7347 T9181 T9183 arg1Of day,(
R7348 T9122 T9121 arg1Of cells,T
R7349 T9122 T9123 arg1Of cells,at
R7350 T9124 T9123 arg2Of day,at
R7351 T9186 T9183 arg2Of C,(
R7352 T9186 T9184 arg1Of C,Fig.
R7353 T9186 T9185 arg1Of C,3
R7354 T9187 T9183 arg3Of ),(
R7355 T9188 T9190 arg1Of We,reported
R7356 T9124 T9125 arg1Of day,6
R7357 T9124 T9126 arg1Of day,of
R7358 T9127 T9126 arg2Of culture,of
R7359 T9188 T9208 arg1Of We,induces
R7360 T9188 T9225 arg1Of We,promoting
R7361 T9190 T9207 arg1Of reported,and
R7362 T9127 T9128 arg1Of culture,(
R7363 T9129 T9128 arg2Of Fig.,(
R7364 T9194 T9192 arg1Of differentiation,Th1
R7365 T9194 T9193 arg1Of differentiation,cell
R7366 T9194 T9195 arg1Of differentiation,was
R7367 T9194 T9196 arg2Of differentiation,regulated
R7368 T9196 T9190 arg2Of regulated,reported
R7369 T9196 T9191 arg1Of regulated,that
R7370 T9196 T9195 arg2Of regulated,was
R7371 T9196 T9197 arg1Of regulated,through
R7372 T9200 T9197 arg2Of loop,through
R7373 T9200 T9198 arg1Of loop,a
R7374 T9200 T9199 arg1Of loop,feed-forward
R7375 T9200 T9201 arg2Of loop,in
R7376 T9200 T9202 arg1Of loop,which
R7377 T9129 T9130 arg1Of Fig.,3
R7378 T9203 T9204 arg1Of T-bet,is
R7379 T9203 T9205 arg2Of T-bet,up-regulated
R7380 T9129 T9131 arg1Of Fig.,","
R7381 T9132 T9133 arg1Of A,and
R7382 T9205 T9201 arg1Of up-regulated,in
R7383 T9205 T9204 arg2Of up-regulated,is
R7384 T9205 T9206 arg1Of up-regulated,early
R7385 T9207 T9189 arg1Of and,previously
R7386 T9208 T9207 arg2Of induces,and
R7387 T9208 T9223 arg1Of induces,","
R7388 T9208 T9225 modOf induces,promoting
R7389 T9209 T9208 arg2Of Runx3,induces
R7390 T9209 T9210 arg1Of Runx3,","
R7391 T9209 T9211 arg2Of Runx3,after
R7392 T9209 T9212 arg1Of Runx3,which
R7393 T9133 T9131 arg2Of and,","
R7394 T9213 T9214 arg1Of T-bet,and
R7395 T9214 T9216 arg1Of and,cooperate
R7396 T9214 T9218 arg1Of and,induce
R7397 T9134 T9133 arg2Of B,and
R7398 T9215 T9214 arg2Of Runx3,and
R7399 T9216 T9211 arg1Of cooperate,after
R7400 T9233 T9232 arg2Of 15,(
R7401 T9218 T9216 arg2Of induce,cooperate
R7402 T9218 T9217 arg1Of induce,to
R7403 T9219 T9220 arg1Of IFN-γ,and
R7404 T9221 T9220 arg2Of silence,and
R7405 T9222 T9218 arg2Of IL-4,induce
R7406 T9222 T9219 arg1Of IL-4,IFN-γ
R7407 T9222 T9221 arg1Of IL-4,silence
R7408 T9233 T9234 arg1Of 15,","
R7409 T9235 T9234 arg2Of 22,","
R7410 T9225 T9224 arg1Of promoting,thus
R7411 T9227 T9225 arg2Of differentiation,promoting
R7412 T9227 T9226 arg1Of differentiation,stable
R7413 T9227 T9228 arg1Of differentiation,toward
R7414 T9227 T9232 arg1Of differentiation,(
R7415 T9236 T9232 arg3Of ),(
R7416 T9241 T9239 arg1Of Runx3,a
R7417 T9231 T9228 arg2Of lineage,toward
R7418 T9231 T9229 arg1Of lineage,the
R7419 T9231 T9230 arg1Of lineage,Th1
R7420 T9241 T9240 arg1Of Runx3,)
R7421 T9241 T9242 arg1Of Runx3,appeared
R7422 T9241 T9243 arg1Of Runx3,necessary
R7423 T9242 T9252 arg1Of appeared,","
R7424 T9243 T9242 arg2Of necessary,appeared
R7425 T9243 T9244 arg1Of necessary,for
R7426 T9330 T9331 arg1Of we,asked
R7427 T9246 T9244 arg2Of induction,for
R7428 T9331 T9328 arg1Of asked,Specifically
R7429 T9331 T9329 arg1Of asked,","
R7430 T9333 T9334 arg1Of Runx3,","
R7431 T9333 T9335 arg1Of Runx3,which
R7432 T9333 T9336 arg1Of Runx3,was
R7433 T9333 T9337 arg1Of Runx3,necessary
R7434 T9246 T9245 arg1Of induction,Eomes
R7435 T9333 T9343 arg1Of Runx3,cooperated
R7436 T9246 T9247 arg1Of induction,(
R7437 T9333 T9347 arg1Of Runx3,regulate
R7438 T9250 T9247 arg2Of A,(
R7439 T9337 T9336 arg2Of necessary,was
R7440 T9337 T9338 arg1Of necessary,for
R7441 T9250 T9248 arg1Of A,Fig.
R7442 T9340 T9338 arg2Of induction,for
R7443 T9340 T9339 arg1Of induction,Eomes
R7444 T9250 T9249 arg1Of A,3
R7445 T9251 T9247 arg3Of ),(
R7446 T9343 T9331 arg2Of cooperated,asked
R7447 T9343 T9332 arg1Of cooperated,whether
R7448 T9343 T9341 arg1Of cooperated,","
R7449 T9343 T9342 arg1Of cooperated,then
R7450 T9343 T9344 arg1Of cooperated,with
R7451 T9343 T9346 modOf cooperated,to
R7452 T9252 T9237 arg2Of ",",Because
R7453 T9345 T9344 arg2Of Eomes,with
R7454 T9252 T9238 arg1Of ",",(
R7455 T9347 T9346 arg1Of regulate,to
R7456 T9254 T9253 arg2Of b,(
R7457 T9348 T9347 arg2Of transcription,regulate
R7458 T9348 T9349 arg1Of transcription,of
R7459 T9255 T9253 arg3Of ),(
R7460 T9354 T9355 arg1Of perforin,","
R7461 T9355 T9358 arg1Of ",",and
R7462 T9257 T9256 arg1Of kinetics,the
R7463 T9356 T9355 arg2Of IFN-γ,","
R7464 T9358 T9349 arg2Of and,of
R7465 T9358 T9350 arg1Of and,the
R7466 T9358 T9351 arg1Of and,effector
R7467 T9358 T9352 arg1Of and,CTL
R7468 T9358 T9353 arg1Of and,markers
R7469 T9358 T9357 arg1Of and,","
R7470 T9360 T9358 arg2Of B,and
R7471 T9360 T9359 arg1Of B,granzyme
R7472 T9362 T9361 arg1Of test,To
R7473 T9257 T9258 arg1Of kinetics,of
R7474 T9364 T9362 arg2Of hypothesis,test
R7475 T9364 T9363 arg1Of hypothesis,this
R7476 T9366 T9362 arg1Of we,test
R7477 T9366 T9367 arg1Of we,used
R7478 T9366 T9375 arg1Of we,ask
R7479 T9367 T9361 modOf used,To
R7480 T9367 T9365 arg1Of used,","
R7481 T9257 T9261 arg1Of kinetics,paralleled
R7482 T9260 T9258 arg2Of expression,of
R7483 T9371 T9370 arg2Of ChIP,(
R7484 T9372 T9370 arg3Of ),(
R7485 T9373 T9367 arg2Of assays,used
R7486 T9373 T9368 arg1Of assays,chromatin
R7487 T9373 T9369 arg1Of assays,immunoprecipitation
R7488 T9373 T9370 arg1Of assays,(
R7489 T9260 T9259 arg1Of expression,Eomes
R7490 T9375 T9367 arg3Of ask,used
R7491 T9375 T9374 arg1Of ask,to
R7492 T9261 T9271 arg1Of paralleled,and
R7493 T9377 T9378 arg1Of Eomes,and
R7494 T9378 T9380 arg1Of and,bound
R7495 T9379 T9378 arg2Of Runx3,and
R7496 T9380 T9375 arg2Of bound,ask
R7497 T9380 T9376 arg1Of bound,whether
R7498 T9262 T9261 arg2Of those,paralleled
R7499 T9382 T9380 arg2Of regions,bound
R7500 T9382 T9381 arg1Of regions,regulatory
R7501 T9382 T9383 arg1Of regions,of
R7502 T9262 T9263 arg1Of those,of
R7503 T9265 T9263 arg2Of expression,of
R7504 T9385 T9386 arg1Of Prf1,","
R7505 T9386 T9389 arg1Of ",",and
R7506 T9387 T9386 arg2Of Ifng,","
R7507 T9389 T9383 arg2Of and,of
R7508 T9389 T9384 arg1Of and,the
R7509 T9389 T9388 arg1Of and,","
R7510 T9265 T9264 arg1Of expression,perforin
R7511 T9391 T9389 arg2Of genes,and
R7512 T9391 T9390 arg1Of genes,Gzmb
R7513 T9391 T9392 arg1Of genes,(
R7514 T9265 T9266 arg1Of expression,(
R7515 T9267 T9266 arg2Of Fig.,(
R7516 T9395 T9392 arg2Of D,(
R7517 T9395 T9393 arg1Of D,Fig.
R7518 T9395 T9394 arg1Of D,3
R7519 T9396 T9392 arg3Of ),(
R7520 T9398 T9397 arg1Of proteins,Both
R7521 T9398 T9399 arg2Of proteins,associated
R7522 T9399 T9400 arg1Of associated,with
R7523 T9267 T9268 arg1Of Fig.,2
R7524 T9269 T9266 arg3Of ),(
R7525 T9403 T9400 arg2Of regions,with
R7526 T9403 T9401 arg1Of regions,gene
R7527 T9403 T9402 arg1Of regions,regulatory
R7528 T9403 T9404 arg1Of regions,in
R7529 T9406 T9404 arg2Of CTLs,in
R7530 T9406 T9405 arg2Of CTLs,differentiated
R7531 T9407 T9408 arg1Of Runx3,bound
R7532 T9271 T9252 arg2Of and,","
R7533 T9408 T9409 arg1Of bound,to
R7534 T9271 T9253 arg1Of and,(
R7535 T9408 T9420 arg1Of bound,;
R7536 T9408 T9421 arg1Of bound,to
R7537 T9408 T9438 arg1Of bound,;
R7538 T9408 T9439 arg1Of bound,to
R7539 T9408 T9455 arg1Of bound,;
R7540 T9408 T9456 arg1Of bound,to
R7541 T9271 T9270 arg1Of and,","
R7542 T9273 T9272 arg2Of c,(
R7543 T9411 T9412 arg1Of Prf1,and
R7544 T9413 T9412 arg2Of Gzmb,and
R7545 T9274 T9272 arg3Of ),(
R7546 T9416 T9409 arg2Of sites,to
R7547 T9416 T9410 arg1Of sites,the
R7548 T9416 T9411 arg1Of sites,Prf1
R7549 T9416 T9413 arg1Of sites,Gzmb
R7550 T9416 T9414 arg1Of sites,transcription
R7551 T9416 T9415 arg1Of sites,start
R7552 T9416 T9417 arg1Of sites,(
R7553 T9418 T9417 arg2Of TSS,(
R7554 T9275 T9272 arg1Of overexpression,(
R7555 T9419 T9417 arg3Of ),(
R7556 T9275 T9276 arg1Of overexpression,of
R7557 T9275 T9278 arg1Of overexpression,in
R7558 T9275 T9285 arg1Of overexpression,led
R7559 T9277 T9276 arg2Of Eo-VP16,of
R7560 T9280 T9281 arg1Of WT,or
R7561 T9281 T9278 arg2Of or,in
R7562 T9426 T9421 arg2Of enhancer,to
R7563 T9426 T9422 arg1Of enhancer,a
R7564 T9426 T9423 arg2Of enhancer,known
R7565 T9426 T9424 arg1Of enhancer,IL-2
R7566 T9426 T9425 arg1Of enhancer,responsive
R7567 T9426 T9427 arg1Of enhancer,located
R7568 T9427 T9428 arg1Of located,near
R7569 T9281 T9279 arg1Of or,either
R7570 T9430 T9428 arg2Of kb,near
R7571 T9430 T9429 arg1Of kb,−1
R7572 T9430 T9431 arg1Of kb,of
R7573 T9284 T9281 arg2Of cells,or
R7574 T9434 T9431 arg2Of gene,of
R7575 T9434 T9432 arg1Of gene,the
R7576 T9434 T9433 arg1Of gene,Prf1
R7577 T9434 T9435 arg1Of gene,(
R7578 T9436 T9435 arg2Of 23,(
R7579 T9437 T9435 arg3Of ),(
R7580 T9284 T9282 arg1Of cells,T-bet–deficient
R7581 T9284 T9283 arg1Of cells,T
R7582 T9285 T9271 arg2Of led,and
R7583 T9285 T9286 arg1Of led,to
R7584 T9288 T9286 arg2Of increase,to
R7585 T9446 T9439 arg2Of site,to
R7586 T9446 T9440 arg1Of site,the
R7587 T9446 T9441 arg1Of site,distal
R7588 T9446 T9442 arg1Of site,CTL-specific
R7589 T9446 T9443 arg1Of site,DNase
R7590 T9446 T9444 arg1Of site,I
R7591 T9446 T9445 arg1Of site,hypersensitive
R7592 T9446 T9447 arg1Of site,9
R7593 T9446 T9448 arg1Of site,in
R7594 T9451 T9448 arg2Of locus,in
R7595 T9451 T9449 arg1Of locus,the
R7596 T9451 T9450 arg1Of locus,Prf1
R7597 T9451 T9452 arg1Of locus,(
R7598 T9288 T9287 arg1Of increase,an
R7599 T9453 T9452 arg2Of 24,(
R7600 T9288 T9289 arg1Of increase,in
R7601 T9454 T9452 arg3Of ),(
R7602 T9291 T9292 arg1Of perforin,and
R7603 T9459 T9456 arg2Of promoter,to
R7604 T9459 T9457 arg1Of promoter,the
R7605 T9459 T9458 arg1Of promoter,Ifng
R7606 T9459 T9460 arg1Of promoter,near
R7607 T9459 T9466 arg2Of promoter,reported
R7608 T9292 T9290 arg1Of and,both
R7609 T9462 T9460 arg2Of TSS,near
R7610 T9462 T9461 arg1Of TSS,the
R7611 T9293 T9292 arg2Of IFN-γ,and
R7612 T9465 T9464 arg1Of previously,as
R7613 T9466 T9463 arg1Of reported,","
R7614 T9466 T9465 arg1Of reported,previously
R7615 T9466 T9467 arg1Of reported,for
R7616 T9466 T9475 arg1Of reported,to
R7617 T9467 T9474 arg1Of for,and
R7618 T9469 T9467 arg2Of cells,for
R7619 T9469 T9468 arg1Of cells,Th1
R7620 T9469 T9470 arg1Of cells,(
R7621 T9294 T9289 arg2Of expression,in
R7622 T9471 T9470 arg2Of 10,(
R7623 T9472 T9470 arg3Of ),(
R7624 T9294 T9291 arg1Of expression,perforin
R7625 T9474 T9473 arg1Of and,;
R7626 T9475 T9474 arg2Of to,and
R7627 T9294 T9293 arg1Of expression,IFN-γ
R7628 T9294 T9295 arg1Of expression,(
R7629 T9296 T9297 arg1Of Fig.,2
R7630 T9480 T9475 arg2Of sites,to
R7631 T9480 T9476 arg1Of sites,several
R7632 T9480 T9477 arg1Of sites,DNase
R7633 T9480 T9478 arg1Of sites,I
R7634 T9480 T9479 arg1Of sites,hypersensitive
R7635 T9480 T9481 arg1Of sites,in
R7636 T9296 T9298 arg1Of Fig.,","
R7637 T9480 T9493 arg1Of sites,(
R7638 T9298 T9300 arg1Of ",",and
R7639 T9299 T9298 arg2Of B,","
R7640 T9484 T9481 arg2Of locus,in
R7641 T9484 T9482 arg1Of locus,the
R7642 T9484 T9483 arg1Of locus,Ifng
R7643 T9484 T9485 arg1Of locus,(
R7644 T9300 T9295 arg2Of and,(
R7645 T9488 T9485 arg2Of D,(
R7646 T9488 T9486 arg1Of D,Fig.
R7647 T9488 T9487 arg1Of D,3
R7648 T9488 T9491 arg1Of D,depicted
R7649 T9491 T9489 arg1Of depicted,and
R7650 T9491 T9490 arg1Of depicted,not
R7651 T9301 T9300 arg2Of D,and
R7652 T9492 T9485 arg3Of ),(
R7653 T9494 T9493 arg2Of 25,(
R7654 T9302 T9295 arg3Of ),(
R7655 T9495 T9493 arg3Of ),(
R7656 T9496 T9497 arg1Of Eomes,bound
R7657 T9304 T9305 arg1Of we,asked
R7658 T9497 T9499 arg1Of bound,to
R7659 T9497 T9508 arg1Of bound,;
R7660 T9499 T9498 arg1Of to,primarily
R7661 T9305 T9237 arg1Of asked,Because
R7662 T9502 T9500 arg1Of TSS,the
R7663 T9502 T9501 arg1Of TSS,Prf1
R7664 T9502 T9503 arg1Of TSS,and
R7665 T9503 T9499 arg2Of and,to
R7666 T9305 T9303 arg1Of asked,","
R7667 T9308 T9307 arg1Of differentiation,CTL
R7668 T9507 T9503 arg2Of enhancer,and
R7669 T9507 T9504 arg1Of enhancer,the
R7670 T9507 T9505 arg1Of enhancer,−1
R7671 T9507 T9506 arg1Of enhancer,kb
R7672 T9510 T9509 arg1Of binding,this
R7673 T9510 T9511 arg1Of binding,was
R7674 T9510 T9513 arg1Of binding,greater
R7675 T9510 T9536 arg1Of binding,comparable
R7676 T9511 T9508 arg2Of was,;
R7677 T9513 T9512 arg1Of greater,substantially
R7678 T9513 T9514 arg1Of greater,than
R7679 T9513 T9535 arg1Of greater,and
R7680 T9515 T9514 arg2Of that,than
R7681 T9515 T9516 arg2Of that,observed
R7682 T9515 T9524 arg1Of that,","
R7683 T9308 T9309 arg1Of differentiation,was
R7684 T9516 T9517 arg1Of observed,at
R7685 T9308 T9312 arg2Of differentiation,regulated
R7686 T9312 T9305 arg2Of regulated,asked
R7687 T9519 T9517 arg2Of promoter,at
R7688 T9519 T9518 arg1Of promoter,the
R7689 T9519 T9520 arg1Of promoter,of
R7690 T9312 T9306 arg1Of regulated,whether
R7691 T9312 T9309 arg2Of regulated,was
R7692 T9312 T9310 arg1Of regulated,also
R7693 T9312 T9311 arg1Of regulated,potentially
R7694 T9316 T9312 arg1Of loop,regulated
R7695 T9523 T9520 arg2Of gene,of
R7696 T9523 T9521 arg1Of gene,the
R7697 T9523 T9522 arg1Of gene,Il2rb
R7698 T9316 T9313 arg2Of loop,by
R7699 T9316 T9314 arg1Of loop,a
R7700 T9528 T9524 arg2Of target,","
R7701 T9528 T9525 arg1Of target,a
R7702 T9528 T9526 arg1Of target,known
R7703 T9528 T9527 arg1Of target,direct
R7704 T9528 T9529 arg1Of target,of
R7705 T9316 T9315 arg1Of loop,feed-forward
R7706 T9530 T9529 arg2Of Eomes,of
R7707 T9530 T9531 arg1Of Eomes,(
R7708 T9316 T9317 arg1Of loop,involving
R7709 T9532 T9531 arg2Of 8,(
R7710 T9321 T9317 arg2Of classes,involving
R7711 T9533 T9531 arg3Of ),(
R7712 T9535 T9511 arg2Of and,was
R7713 T9535 T9534 arg1Of and,","
R7714 T9536 T9535 arg2Of comparable,and
R7715 T9536 T9537 arg1Of comparable,to
R7716 T9538 T9537 arg2Of that,to
R7717 T9538 T9539 arg2Of that,observed
R7718 T9538 T9544 arg1Of that,","
R7719 T9539 T9540 arg1Of observed,at
R7720 T9321 T9318 arg1Of classes,these
R7721 T9321 T9319 arg1Of classes,same
R7722 T9543 T9540 arg2Of TSS,at
R7723 T9543 T9541 arg1Of TSS,the
R7724 T9543 T9542 arg1Of TSS,Ifng
R7725 T9321 T9320 arg1Of classes,two
R7726 T9321 T9322 arg1Of classes,of
R7727 T9547 T9544 arg2Of target,","
R7728 T9547 T9545 arg1Of target,a
R7729 T9547 T9546 arg2Of target,known
R7730 T9547 T9548 arg1Of target,of
R7731 T9547 T9551 arg1Of target,in
R7732 T9323 T9324 arg1Of Runx,and
R7733 T9547 T9563 arg1Of target,(
R7734 T9550 T9548 arg2Of proteins,of
R7735 T9550 T9549 arg1Of proteins,T-box
R7736 T9325 T9324 arg2Of T-box,and
R7737 T9327 T9322 arg2Of factors,of
R7738 T9557 T9551 arg2Of cells,in
R7739 T9557 T9552 arg1Of cells,both
R7740 T9557 T9553 arg1Of cells,Th1
R7741 T9557 T9554 arg1Of cells,and
R7742 T9557 T9555 arg1Of cells,CD8+
R7743 T9557 T9556 arg1Of cells,T
R7744 T9557 T9558 arg1Of cells,(
R7745 T9327 T9323 arg1Of factors,Runx
R7746 T9327 T9325 arg1Of factors,T-box
R7747 T9561 T9558 arg2Of D,(
R7748 T9561 T9559 arg1Of D,Fig.
R7749 T9561 T9560 arg1Of D,3
R7750 T9562 T9558 arg3Of ),(
R7751 T9327 T9326 arg1Of factors,transcription
R7752 T9622 T9619 arg2Of cells,and
R7753 T9564 T9563 arg2Of 17,(
R7754 T9565 T9563 arg3Of ),(
R7755 T9567 T9566 arg1Of determine,To
R7756 T9569 T9570 arg1Of Runx3,controlled
R7757 T9570 T9567 arg2Of controlled,determine
R7758 T9570 T9568 arg1Of controlled,whether
R7759 T9570 T9577 arg1Of controlled,through
R7760 T9622 T9620 arg1Of cells,CD8+CD4+
R7761 T9572 T9570 arg2Of expression,controlled
R7762 T9572 T9571 arg1Of expression,the
R7763 T9572 T9573 arg1Of expression,of
R7764 T9622 T9621 arg1Of cells,DP
R7765 T9626 T9623 arg2Of experiments,in
R7766 T9576 T9573 arg2Of genes,of
R7767 T9576 T9574 arg1Of genes,CTL
R7768 T9576 T9575 arg1Of genes,effector
R7769 T9579 T9577 arg2Of induction,through
R7770 T9579 T9578 arg1Of induction,its
R7771 T9579 T9580 arg1Of induction,of
R7772 T9581 T9580 arg2Of Eomes,of
R7773 T9583 T9567 arg1Of we,determine
R7774 T9583 T9585 arg1Of we,expressed
R7775 T9585 T9566 modOf expressed,To
R7776 T9585 T9582 arg1Of expressed,","
R7777 T9585 T9584 arg1Of expressed,retrovirally
R7778 T9585 T9589 arg1Of expressed,in
R7779 T9586 T9587 arg1Of Runx3,and
R7780 T9626 T9624 arg1Of experiments,our
R7781 T9587 T9585 arg2Of and,expressed
R7782 T9626 T9625 arg1Of experiments,previous
R7783 T9588 T9587 arg2Of Eo-VP16,and
R7784 T9628 T9629 arg1Of we,used
R7785 T9592 T9589 arg2Of cells,in
R7786 T9592 T9590 arg1Of cells,CD8+
R7787 T9592 T9591 arg1Of cells,T
R7788 T9592 T9593 arg1Of cells,from
R7789 T9629 T9596 arg1Of used,Because
R7790 T9595 T9593 arg2Of mice,from
R7791 T9595 T9594 arg1Of mice,Runx3−/−
R7792 T9596 T9597 arg1Of Because,of
R7793 T9596 T9609 arg1Of Because,and
R7794 T9629 T9610 arg1Of used,because
R7795 T9629 T9627 arg1Of used,","
R7796 T9600 T9596 arg2Of number,Because
R7797 T9600 T9598 arg1Of number,the
R7798 T9600 T9599 arg1Of number,limited
R7799 T9600 T9601 arg1Of number,of
R7800 T9600 T9605 arg1Of number,in
R7801 T9629 T9635 arg1Of used,without
R7802 T9629 T9638 arg1Of used,as
R7803 T9604 T9601 arg2Of cells,of
R7804 T9604 T9602 arg1Of cells,CD8+
R7805 T9604 T9603 arg1Of cells,T
R7806 T9634 T9629 arg2Of cells,used
R7807 T9607 T9605 arg2Of mice,in
R7808 T9607 T9606 arg1Of mice,these
R7809 T9609 T9608 arg1Of and,","
R7810 T9610 T9609 arg2Of because,and
R7811 T9611 T9612 arg1Of we,saw
R7812 T9612 T9610 arg2Of saw,because
R7813 T9612 T9623 arg1Of saw,in
R7814 T9634 T9630 arg1Of cells,total
R7815 T9614 T9612 arg2Of difference,saw
R7816 T9634 T9631 arg1Of cells,Runx3−/−
R7817 T9634 T9632 arg1Of cells,CD8+
R7818 T9634 T9633 arg1Of cells,T
R7819 T9637 T9635 arg2Of fractionation,without
R7820 T9614 T9613 arg1Of difference,no
R7821 T9614 T9615 arg1Of difference,between
R7822 T9618 T9616 arg1Of SP,Runx3−/−
R7823 T9618 T9617 arg1Of SP,CD8+CD4−
R7824 T9618 T9619 arg1Of SP,and
R7825 T9619 T9615 arg2Of and,between
R7826 T9637 T9636 arg1Of fractionation,further
R7827 T9639 T9638 arg2Of recipients,as
R7828 T9639 T9640 arg1Of recipients,for
R7829 T9642 T9640 arg2Of transduction,for
R7830 T9719 T9718 arg1Of though,even
R7831 T9642 T9641 arg1Of transduction,retroviral
R7832 T9643 T9644 arg1Of Reconstitution,of
R7833 T9720 T9721 arg1Of it,restored
R7834 T9721 T9719 arg2Of restored,though
R7835 T9643 T9649 arg1Of Reconstitution,with
R7836 T9643 T9651 arg1Of Reconstitution,restored
R7837 T9723 T9721 arg2Of capacity,restored
R7838 T9723 T9722 arg1Of capacity,the
R7839 T9723 T9724 modOf capacity,to
R7840 T9648 T9644 arg2Of cells,of
R7841 T9725 T9724 arg1Of induce,to
R7842 T9725 T9728 arg1Of induce,upon
R7843 T9727 T9725 arg2Of expression,induce
R7844 T9727 T9726 arg1Of expression,IFN-γ
R7845 T9730 T9728 arg2Of restimulation,upon
R7846 T9730 T9729 arg1Of restimulation,TCR
R7847 T9730 T9731 arg1Of restimulation,(
R7848 T9732 T9731 arg2Of Fig.,(
R7849 T9732 T9733 arg1Of Fig.,4
R7850 T9732 T9734 arg1Of Fig.,","
R7851 T9648 T9645 arg1Of cells,Runx3−/−
R7852 T9648 T9646 arg1Of cells,CD8+
R7853 T9735 T9736 arg1Of A,and
R7854 T9648 T9647 arg1Of cells,T
R7855 T9736 T9734 arg2Of and,","
R7856 T9650 T9649 arg2Of Runx3,with
R7857 T9737 T9736 arg2Of B,and
R7858 T9738 T9731 arg3Of ),(
R7859 T9740 T9739 arg1Of result,This
R7860 T9740 T9741 arg1Of result,suggests
R7861 T9741 T9742 arg1Of suggests,strongly
R7862 T9652 T9651 arg2Of expression,restored
R7863 T9652 T9653 arg1Of expression,of
R7864 T9745 T9744 arg1Of expression,perforin
R7865 T9745 T9746 arg1Of expression,requires
R7866 T9746 T9741 arg2Of requires,suggests
R7867 T9746 T9743 arg1Of requires,that
R7868 T9652 T9665 arg1Of expression,(
R7869 T9747 T9748 arg1Of Runx3,and
R7870 T9748 T9746 arg2Of and,requires
R7871 T9749 T9748 arg2Of Eomes,and
R7872 T9654 T9657 arg1Of Eomes,as
R7873 T9751 T9750 arg2Of expected,As
R7874 T9751 T9752 arg1Of expected,from
R7875 T9657 T9653 arg2Of as,of
R7876 T9754 T9752 arg2Of defect,from
R7877 T9754 T9753 arg1Of defect,their
R7878 T9754 T9755 arg1Of defect,in
R7879 T9756 T9757 arg1Of perforin,and
R7880 T9758 T9757 arg2Of granzyme,and
R7881 T9760 T9755 arg2Of expression,in
R7882 T9760 T9756 arg1Of expression,perforin
R7883 T9760 T9758 arg1Of expression,granzyme
R7884 T9760 T9759 arg1Of expression,B
R7885 T9657 T9655 arg1Of as,as
R7886 T9657 T9656 arg1Of as,well
R7887 T9658 T9659 arg1Of perforin,","
R7888 T9765 T9762 arg1Of cells,Runx3−/−
R7889 T9765 T9763 arg1Of cells,CD8+
R7890 T9765 T9764 arg1Of cells,T
R7891 T9765 T9766 arg1Of cells,showed
R7892 T9766 T9750 arg1Of showed,As
R7893 T9766 T9761 arg1Of showed,","
R7894 T9766 T9770 arg1Of showed,in
R7895 T9768 T9767 arg1Of cytolytic,defective
R7896 T9659 T9663 arg1Of ",",and
R7897 T9769 T9766 arg2Of activity,showed
R7898 T9769 T9768 arg1Of activity,cytolytic
R7899 T9661 T9659 arg2Of B,","
R7900 T9774 T9770 arg2Of reaction,in
R7901 T9774 T9771 arg1Of reaction,a
R7902 T9774 T9772 arg1Of reaction,mixed
R7903 T9774 T9773 arg1Of reaction,lymphocyte
R7904 T9774 T9775 arg1Of reaction,(
R7905 T9776 T9775 arg2Of 12,(
R7906 T9661 T9660 arg1Of B,granzyme
R7907 T9777 T9775 arg3Of ),(
R7908 T9663 T9657 arg2Of and,as
R7909 T9663 T9662 arg1Of and,","
R7910 T9664 T9663 arg2Of IFN-γ,and
R7911 T9783 T9780 arg1Of cells,TCR-stimulated
R7912 T9783 T9781 arg1Of cells,Runx3−/−
R7913 T9783 T9782 arg1Of cells,CD8+
R7914 T9783 T9784 arg1Of cells,were
R7915 T9783 T9786 arg1Of cells,effective
R7916 T9784 T9778 arg1Of were,However
R7917 T9784 T9779 arg1Of were,","
R7918 T9786 T9784 arg2Of effective,were
R7919 T9786 T9785 arg1Of effective,as
R7920 T9786 T9787 arg1Of effective,as
R7921 T9789 T9787 arg2Of cells,as
R7922 T9666 T9665 arg2Of Fig.,(
R7923 T9789 T9788 arg1Of cells,WT
R7924 T9789 T9790 arg1Of cells,in
R7925 T9666 T9667 arg1Of Fig.,4
R7926 T9791 T9790 arg2Of killing,in
R7927 T9791 T9794 arg1Of killing,in
R7928 T9666 T9668 arg1Of Fig.,","
R7929 T9669 T9670 arg1Of A,and
R7930 T9793 T9791 arg2Of cells,killing
R7931 T9793 T9792 arg1Of cells,tumor
R7932 T9670 T9668 arg2Of and,","
R7933 T9798 T9794 arg2Of assay,in
R7934 T9798 T9795 arg1Of assay,a
R7935 T9798 T9796 arg1Of assay,redirected
R7936 T9798 T9797 arg1Of assay,CTL
R7937 T9798 T9799 arg1Of assay,(
R7938 T9800 T9799 arg2Of 12,(
R7939 T9671 T9670 arg2Of B,and
R7940 T9801 T9799 arg3Of ),(
R7941 T9672 T9665 arg3Of ),(
R7942 T9805 T9804 arg1Of cells,CD8+
R7943 T9805 T9806 arg1Of cells,from
R7944 T9805 T9813 arg2Of cells,immunized
R7945 T9805 T9819 arg1Of cells,killed
R7946 T9674 T9673 arg2Of addition,In
R7947 T9809 T9806 arg2Of cavity,from
R7948 T9809 T9807 arg1Of cavity,the
R7949 T9809 T9808 arg1Of cavity,peritoneal
R7950 T9809 T9810 arg1Of cavity,of
R7951 T9678 T9676 arg1Of cells,Runx3−/−
R7952 T9812 T9810 arg2Of mice,of
R7953 T9812 T9811 arg1Of mice,Runx3−/−
R7954 T9813 T9814 arg1Of immunized,with
R7955 T9678 T9677 arg1Of cells,T
R7956 T9678 T9679 arg1Of cells,showed
R7957 T9679 T9673 arg1Of showed,In
R7958 T9679 T9675 arg1Of showed,","
R7959 T9679 T9693 arg1Of showed,","
R7960 T9679 T9694 modOf showed,indicating
R7961 T9817 T9814 arg2Of cells,with
R7962 T9817 T9815 arg1Of cells,certain
R7963 T9817 T9816 arg1Of cells,tumor
R7964 T9682 T9679 arg2Of up-regulation,showed
R7965 T9819 T9802 arg1Of killed,Furthermore
R7966 T9819 T9803 arg1Of killed,","
R7967 T9819 T9818 arg1Of killed,effectively
R7968 T9821 T9819 arg2Of targets,killed
R7969 T9821 T9820 arg1Of targets,these
R7970 T9821 T9822 arg1Of targets,(
R7971 T9823 T9822 arg2Of 13,(
R7972 T9824 T9822 arg3Of ),(
R7973 T9682 T9680 arg1Of up-regulation,a
R7974 T9682 T9681 arg1Of up-regulation,compensatory
R7975 T9828 T9829 arg1Of activation,of
R7976 T9682 T9683 arg1Of up-regulation,of
R7977 T9828 T9834 arg1Of activation,is
R7978 T9828 T9835 arg1Of activation,defective
R7979 T9682 T9685 arg1Of up-regulation,","
R7980 T9682 T9686 arg1Of up-regulation,which
R7981 T9682 T9687 arg1Of up-regulation,was
R7982 T9833 T9829 arg2Of machinery,of
R7983 T9833 T9830 arg1Of machinery,the
R7984 T9833 T9831 arg1Of machinery,perforin/granzyme
R7985 T9833 T9832 arg1Of machinery,B
R7986 T9834 T9827 arg2Of is,although
R7987 T9682 T9688 arg2Of up-regulation,suppressed
R7988 T9835 T9834 arg2Of defective,is
R7989 T9835 T9836 arg1Of defective,in
R7990 T9684 T9683 arg2Of Runx1,of
R7991 T9839 T9836 arg2Of cells,in
R7992 T9839 T9837 arg1Of cells,Runx3−/−
R7993 T9839 T9838 arg1Of cells,CD8+
R7994 T9688 T9687 arg2Of suppressed,was
R7995 T9842 T9841 arg1Of cells,these
R7996 T9842 T9843 arg1Of cells,are
R7997 T9842 T9846 arg1Of cells,devoid
R7998 T9842 T9851 arg1Of cells,could
R7999 T9842 T9854 arg1Of cells,kill
R8000 T9843 T9844 arg1Of are,not
R8001 T9843 T9850 arg1Of are,and
R8002 T9846 T9843 arg2Of devoid,are
R8003 T9846 T9845 arg1Of devoid,entirely
R8004 T9846 T9847 arg1Of devoid,of
R8005 T9688 T9689 arg1Of suppressed,upon
R8006 T9849 T9847 arg2Of activity,of
R8007 T9849 T9848 arg1Of activity,cytolytic
R8008 T9850 T9825 arg1Of and,Therefore
R8009 T9850 T9826 arg1Of and,","
R8010 T9850 T9827 arg1Of and,although
R8011 T9850 T9840 arg1Of and,","
R8012 T9850 T9856 arg1Of and,","
R8013 T9850 T9858 arg1Of and,by
R8014 T9690 T9689 arg2Of reconstitution,upon
R8015 T9854 T9850 arg2Of kill,and
R8016 T9854 T9851 arg2Of kill,could
R8017 T9854 T9852 arg1Of kill,still
R8018 T9854 T9853 arg1Of kill,effectively
R8019 T9855 T9854 arg2Of targets,kill
R8020 T9690 T9691 arg1Of reconstitution,with
R8021 T9858 T9857 arg1Of by,possibly
R8022 T9860 T9858 arg2Of mechanisms,by
R8023 T9860 T9859 arg1Of mechanisms,alternative
R8024 T9692 T9691 arg2Of Runx3,with
R8025 T9860 T9862 arg1Of mechanisms,as
R8026 T9696 T9697 arg1Of Runx1,is
R8027 T9862 T9861 arg1Of as,such
R8028 T9866 T9862 arg2Of pathway,as
R8029 T9866 T9863 arg1Of pathway,the
R8030 T9866 T9864 arg1Of pathway,Fas–Fas
R8031 T9866 T9865 arg1Of pathway,ligand
R8032 T9697 T9694 arg2Of is,indicating
R8033 T9697 T9695 arg1Of is,that
R8034 T9699 T9697 arg2Of target,is
R8035 T9699 T9698 arg1Of target,a
R8036 T9699 T9700 arg1Of target,of
R8037 T9699 T9702 arg1Of target,by
R8038 T9701 T9700 arg2Of repression,of
R8039 T9703 T9702 arg2Of Runx3,by
R8040 T9706 T9707 arg1Of Eo-VP16,did
R8043 T9706 T9709 arg1Of Eo-VP16,up-regulate
R8044 T9709 T9704 arg1Of up-regulate,Notably
R8047 T9709 T9705 arg1Of up-regulate,","
R8050 T9709 T9707 arg2Of up-regulate,did
R8051 T9709 T9708 arg1Of up-regulate,not
R8052 T9709 T9712 arg1Of up-regulate,when
R8053 T9709 T9717 arg1Of up-regulate,","
R8054 T9709 T9719 arg1Of up-regulate,though
R8055 T9711 T9709 arg2Of expression,up-regulate
R8056 T9711 T9710 arg1Of expression,perforin
R8057 T9713 T9712 arg2Of expressed,when
R8058 T9713 T9714 arg1Of expressed,in
R8059 T9716 T9714 arg2Of cells,in
R8060 T9716 T9715 arg1Of cells,Runx3−/−
R16331 T21280 T21281 arg1Of Runx3,controls
R16332 T21282 T21281 arg2Of Eomes,controls
R16333 T21282 T21283 arg1Of Eomes,","
R16334 T21284 T21285 arg1Of perforin,","
R16335 T21285 T21289 arg1Of ",",and
R16336 T21287 T21285 arg2Of B,","
R16337 T21287 T21286 arg1Of B,granzyme
R16338 T21289 T21283 arg2Of and,","
R16339 T21289 T21288 arg1Of and,","
R16340 T21289 T21292 arg1Of and,in
R16341 T21291 T21289 arg2Of expression,and
R16342 T21291 T21290 arg1Of expression,IFN-γ
R16343 T21294 T21292 arg2Of CTLs,in
R16344 T21294 T21293 arg1Of CTLs,effector
R16345 T21295 T21296 arg1Of Runx3+/+,or
R16346 T21297 T21296 arg2Of Runx3−/−,or
R16347 T21300 T21295 arg1Of cells,Runx3+/+
R16348 T21300 T21297 arg1Of cells,Runx3−/−
R16349 T21300 T21298 arg1Of cells,CD8+
R16350 T21300 T21299 arg1Of cells,T
R16351 T21300 T21301 arg1Of cells,were
R16352 T21300 T21302 arg2Of cells,activated
R16353 T21300 T21304 arg2Of cells,transduced
R16354 T21302 T21303 arg1Of activated,and
R16355 T21303 T21301 arg2Of and,were
R16356 T21304 T21303 arg2Of transduced,and
R16357 T21304 T21305 arg1Of transduced,with
R16358 T21306 T21305 arg2Of retroviruses,with
R16359 T21306 T21307 arg1Of retroviruses,bearing
R16360 T21306 T21317 arg1Of retroviruses,encoding
R16361 T21307 T21315 arg1Of bearing,or
R16362 T21311 T21307 arg2Of cassette,bearing
R16363 T21311 T21308 arg1Of cassette,an
R16364 T21311 T21309 arg1Of cassette,empty
R16365 T21311 T21310 arg1Of cassette,IRES-GFP
R16366 T21311 T21312 arg1Of cassette,(
R16367 T21313 T21312 arg2Of GFP,(
R16368 T21314 T21312 arg3Of ),(
R16369 T21317 T21315 arg2Of encoding,or
R16370 T21317 T21316 arg1Of encoding,also
R16371 T21318 T21319 arg1Of Eomes-VP16,(
R16372 T21318 T21322 arg1Of Eomes-VP16,or
R16373 T21320 T21319 arg2Of Eo-VP16,(
R16374 T21321 T21319 arg3Of ),(
R16375 T21322 T21317 arg2Of or,encoding
R16376 T21323 T21322 arg2Of Myc-Runx3,or
R16377 T21323 T21324 arg1Of Myc-Runx3,(
R16378 T21325 T21324 arg2Of Runx3,(
R16379 T21326 T21324 arg3Of ),(
R16380 T21328 T21327 arg1Of frequency,The
R16381 T21328 T21329 arg1Of frequency,of
R16382 T21328 T21332 arg1Of frequency,in
R16383 T21328 T21335 arg1Of frequency,was
R16384 T21328 T21336 arg1Of frequency,equivalent
R16385 T21331 T21329 arg2Of cells,of
R16386 T21331 T21330 arg2Of cells,transduced
R16387 T21334 T21332 arg2Of cultures,in
R16388 T21334 T21333 arg1Of cultures,the
R16389 T21336 T21335 arg2Of equivalent,was
R16390 T21336 T21337 arg1Of equivalent,for
R16391 T21339 T21337 arg2Of constructs,for
R16392 T21339 T21338 arg1Of constructs,all
R16393 T21339 T21340 arg1Of constructs,(
R16394 T21341 T21342 arg1Of ∼75–90,%
R16395 T21344 T21340 arg2Of cells,(
R16396 T21344 T21341 arg1Of cells,∼75–90
R16397 T21344 T21343 arg1Of cells,GFP+
R16398 T21344 T21345 arg1Of cells,;
R16399 T21344 T21347 arg2Of cells,depicted
R16400 T21347 T21346 arg1Of depicted,not
R16401 T21348 T21340 arg3Of ),(
R16402 T21350 T21349 arg2Of (,.
R16403 T21351 T21349 arg3Of A,.
R16404 T21353 T21349 arg1Of in express,.
R16405 T21353 T21352 arg1Of in express,) Prote
R16406 T21353 T21354 arg1Of in express,io
R16407 T21353 T21361 arg1Of in express,(da
R16408 T21353 T21362 arg2Of in express,y 6) was
R16409 T21356 T21354 arg2Of -cell ex,io
R16410 T21356 T21355 arg1Of -cell ex,n in whole
R16411 T21356 T21357 arg1Of -cell ex,t
R16412 T21358 T21357 arg2Of rac,t
R16413 T21358 T21359 arg1Of rac,t
R16414 T21360 T21357 arg3Of s,t
R16415 T21362 T21335 arg3Of y 6) was,was
R16416 T21362 T21361 arg2Of y 6) was,(da
R16417 T21364 T21362 arg1Of alyzed by immu,y 6) was
R16418 T21364 T21363 arg2Of alyzed by immu,an
R16419 T21365 T21366 arg1Of Overexpression,of
R16420 T21365 T21368 arg1Of Overexpression,can
R16421 T21365 T21370 arg1Of Overexpression,be
R16422 T21365 T21371 arg2Of Overexpression,detected
R16423 T21367 T21366 arg2Of Eomes-VP16,of
R16424 T21371 T21368 arg2Of detected,can
R16425 T21371 T21369 arg1Of detected,not
R16426 T21371 T21370 arg2Of detected,be
R16427 T21371 T21372 arg1Of detected,with
R16428 T21371 T21376 arg1Of detected,","
R16429 T21371 T21377 arg1Of detected,as
R16430 T21374 T21373 arg1Of Eomes,the
R16431 T21375 T21372 arg2Of antibody,with
R16432 T21375 T21374 arg1Of antibody,Eomes
R16433 T21380 T21378 arg1Of epitope,the
R16434 T21380 T21379 arg1Of epitope,C-terminal
R16435 T21380 T21381 arg1Of epitope,is
R16436 T21380 T21382 arg1Of epitope,within
R16437 T21381 T21408 arg1Of is,and
R16438 T21382 T21381 arg2Of within,is
R16439 T21384 T21382 arg2Of region,within
R16440 T21384 T21383 arg1Of region,the
R16441 T21384 T21385 arg1Of region,that
R16442 T21384 T21386 arg1Of region,has
R16443 T21384 T21387 arg1Of region,been
R16444 T21384 T21388 arg2Of region,replaced
R16445 T21388 T21386 arg2Of replaced,has
R16446 T21388 T21387 arg2Of replaced,been
R16447 T21388 T21389 arg1Of replaced,with
R16448 T21388 T21403 arg1Of replaced,after
R16449 T21393 T21391 arg1Of domain.,VP16
R16450 T21393 T21392 arg1Of domain.,transactivation
R16451 T21393 T21394 arg1Of domain.,(
R16452 T21395 T21394 arg2Of B,(
R16453 T21396 T21394 arg3Of ),(
R16454 T21397 T21389 arg2Of Expression,with
R16455 T21397 T21390 arg1Of Expression,the
R16456 T21397 T21393 arg1Of Expression,domain.
R16457 T21397 T21398 arg1Of Expression,of
R16458 T21400 T21399 arg1Of B,granzyme
R16459 T21400 T21401 arg1Of B,and
R16460 T21401 T21398 arg2Of and,of
R16461 T21402 T21401 arg2Of IFN-γ,and
R16462 T21404 T21403 arg2Of culture,after
R16463 T21404 T21405 arg1Of culture,for
R16464 T21407 T21405 arg2Of d,for
R16465 T21407 T21406 arg1Of d,6
R16466 T21408 T21377 arg2Of and,as
R16467 T21409 T21410 arg1Of restimulation,for
R16468 T21409 T21417 arg1Of restimulation,was
R16469 T21409 T21418 arg2Of restimulation,determined
R16470 T21412 T21410 arg2Of h,for
R16471 T21412 T21411 arg1Of h,4
R16472 T21412 T21413 arg1Of h,with
R16473 T21414 T21415 arg1Of PMA,and
R16474 T21415 T21413 arg2Of and,with
R16475 T21416 T21415 arg2Of ionomycin,and
R16476 T21418 T21408 arg2Of determined,and
R16477 T21418 T21417 arg2Of determined,was
R16478 T21421 T21418 arg1Of staining,determined
R16479 T21421 T21419 arg2Of staining,by
R16480 T21421 T21420 arg1Of staining,intracellular
R16481 T21423 T21422 arg1Of percentage,The
R16482 T21423 T21424 arg1Of percentage,of
R16483 T21423 T21428 arg1Of percentage,is
R16484 T21423 T21429 arg2Of percentage,shown
R16485 T21426 T21425 arg1Of stained,positively
R16486 T21427 T21424 arg2Of cells,of
R16487 T21427 T21426 arg1Of cells,stained
R16488 T21429 T21428 arg2Of shown,is
R16489 T21429 T21430 arg1Of shown,above
R16490 T21429 T21433 arg1Of shown,;
R16491 T21432 T21430 arg2Of gate,above
R16492 T21432 T21431 arg1Of gate,the
R16493 T21437 T21434 arg1Of intensity,the
R16494 T21437 T21435 arg1Of intensity,mean
R16495 T21437 T21436 arg1Of intensity,fluorescence
R16496 T21437 T21438 arg1Of intensity,(
R16497 T21437 T21441 arg1Of intensity,of
R16498 T21437 T21449 arg1Of intensity,is
R16499 T21437 T21450 arg2Of intensity,shown
R16500 T21439 T21438 arg2Of MFI,(
R16501 T21440 T21438 arg3Of ),(
R16502 T21444 T21441 arg2Of staining,of
R16503 T21444 T21442 arg1Of staining,granzyme
R16504 T21444 T21443 arg1Of staining,B
R16505 T21444 T21445 arg1Of staining,for
R16506 T21448 T21445 arg2Of population,for
R16507 T21448 T21446 arg1Of population,the
R16508 T21448 T21447 arg1Of population,total
R16509 T21450 T21433 arg2Of shown,;
R16510 T21450 T21449 arg2Of shown,is
R16511 T21450 T21451 arg1Of shown,below
R16512 T21453 T21451 arg2Of gate,below
R16513 T21453 T21452 arg1Of gate,the
R16514 T21457 T21454 arg1Of lines,The
R16515 T21457 T21455 arg1Of lines,vertical
R16516 T21457 T21456 arg1Of lines,gray
R16517 T21457 T21458 arg1Of lines,indicate
R16518 T21460 T21458 arg2Of MFI,indicate
R16519 T21460 T21459 arg1Of MFI,the
R16520 T21460 T21461 arg1Of MFI,for
R16521 T21464 T21461 arg2Of cells,for
R16522 T21464 T21462 arg1Of cells,WT
R16523 T21464 T21463 arg1Of cells,GFP+
R16524 T21465 T21466 arg1Of Results,are
R16525 T21465 T21467 arg1Of Results,representative
R16526 T21467 T21466 arg2Of representative,are
R16527 T21467 T21468 arg1Of representative,of
R16528 T21471 T21469 arg1Of two,at
R16529 T21471 T21470 arg1Of two,least
R16530 T21473 T21468 arg2Of experiments.,of
R16531 T21473 T21471 arg1Of experiments.,two
R16532 T21473 T21472 arg1Of experiments.,independent
R16533 T21473 T21474 arg1Of experiments.,(
R16534 T21473 T21478 arg1Of experiments.,diagram
R16535 T21475 T21474 arg2Of C,(
R16536 T21476 T21474 arg3Of ),(
R16537 T21478 T21477 arg1Of diagram,Schematic
R16538 T21478 T21479 arg1Of diagram,of
R16539 T21482 T21479 arg2Of network,of
R16540 T21482 T21480 arg1Of network,the
R16541 T21482 T21481 arg1Of network,transcriptional
R16542 T21482 T21483 arg1Of network,involving
R16543 T21484 T21485 arg1Of Runx3,and
R16544 T21485 T21483 arg2Of and,involving
R16545 T21487 T21485 arg2Of factors,and
R16546 T21487 T21486 arg1Of factors,T-box
R16547 T21488 T21489 arg1Of T-bet,is
R16548 T21488 T21490 arg2Of T-bet,induced
R16549 T21488 T21495 arg1Of T-bet,is
R16550 T21488 T21496 arg1Of T-bet,essential
R16551 T21490 T21489 arg2Of induced,is
R16552 T21490 T21494 arg1Of induced,and
R16553 T21493 T21490 arg1Of signals,induced
R16554 T21493 T21491 arg2Of signals,by
R16555 T21493 T21492 arg1Of signals,TCR
R16556 T21495 T21494 arg2Of is,and
R16557 T21496 T21495 arg2Of essential,is
R16558 T21496 T21497 arg1Of essential,for
R16559 T21500 T21497 arg2Of expression,for
R16560 T21500 T21498 arg1Of expression,early
R16561 T21500 T21499 arg1Of expression,IFN-γ
R16562 T21501 T21502 arg1Of Runx3,is
R16563 T21501 T21503 arg1Of Runx3,present
R16564 T21501 T21510 arg1Of Runx3,represses
R16565 T21501 T21513 arg1Of Runx3,induces
R16566 T21502 T21509 arg1Of is,and
R16567 T21503 T21502 arg2Of present,is
R16568 T21503 T21504 arg1Of present,in
R16569 T21508 T21504 arg2Of cells,in
R16570 T21508 T21505 arg1Of cells,naive
R16571 T21508 T21506 arg1Of cells,CD8+
R16572 T21508 T21507 arg1Of cells,T
R16573 T21510 T21512 arg1Of represses,and
R16574 T21511 T21510 arg2Of Runx1,represses
R16575 T21512 T21509 arg2Of and,and
R16576 T21513 T21512 arg2Of induces,and
R16577 T21514 T21513 arg2Of Eomes,induces
R16578 T21514 T21515 arg1Of Eomes,","
R16579 T21516 T21517 arg1Of perforin,","
R16580 T21517 T21521 arg1Of ",",and
R16581 T21519 T21517 arg2Of B,","
R16582 T21519 T21518 arg1Of B,granzyme
R16583 T21521 T21515 arg2Of and,","
R16584 T21521 T21520 arg1Of and,","
R16585 T21523 T21521 arg2Of expression,and
R16586 T21523 T21522 arg1Of expression,IFN-γ
R16587 T21524 T21525 arg1Of Eomes,may
R16588 T21524 T21526 arg1Of Eomes,participate
R16589 T21526 T21525 arg2Of participate,may
R16590 T21526 T21527 arg1Of participate,in
R16591 T21526 T21533 arg1Of participate,whereas
R16592 T21528 T21527 arg2Of sustaining,in
R16593 T21531 T21528 arg2Of expression,sustaining
R16594 T21531 T21529 arg1Of expression,late
R16595 T21531 T21530 arg1Of expression,IFN-γ
R16596 T21533 T21532 arg1Of whereas,","
R16597 T21534 T21535 arg1Of Runx3,and
R16598 T21535 T21537 arg1Of and,(
R16599 T21535 T21542 arg1Of and,may
R16600 T21535 T21543 arg1Of and,cooperate
R16601 T21535 T21545 arg1Of and,activate
R16602 T21536 T21535 arg2Of Eomes,and
R16603 T21538 T21539 arg1Of but,not
R16604 T21540 T21537 arg2Of T-bet,(
R16605 T21540 T21538 arg1Of T-bet,but
R16606 T21541 T21537 arg3Of ),(
R16607 T21543 T21533 arg2Of cooperate,whereas
R16608 T21543 T21542 arg2Of cooperate,may
R16609 T21545 T21543 arg2Of activate,cooperate
R16610 T21545 T21544 arg1Of activate,to
R16611 T21547 T21545 arg2Of expression,activate
R16612 T21547 T21546 arg1Of expression,perforin
R16613 T21550 T21548 arg1Of line,The
R16614 T21550 T21549 arg1Of line,dotted
R16615 T21550 T21551 arg1Of line,indicates
R16616 T21554 T21551 arg2Of effect,indicates
R16617 T21554 T21552 arg1Of effect,the
R16618 T21554 T21553 arg1Of effect,partial
R16619 T21554 T21555 arg1Of effect,of
R16620 T21554 T21558 arg1Of effect,on
R16621 T21557 T21555 arg2Of deficiency,of
R16622 T21557 T21556 arg1Of deficiency,T-bet
R16623 T21560 T21559 arg1Of mRNA,Gzmb
R16624 T21560 T21561 arg1Of mRNA,but
R16625 T21561 T21558 arg2Of but,on
R16626 T21566 T21561 arg2Of expression,but
R16627 T21566 T21562 arg1Of expression,not
R16628 T21566 T21563 arg1Of expression,granzyme
R16629 T21566 T21564 arg1Of expression,B
R16630 T21566 T21565 arg1Of expression,protein

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T9873 5025-5032 Antecedent denotes Eo-VP16
T9874 6982-6987 Anaphor denotes their
T9875 5277-5282 Antecedent denotes Runx3
T9876 5287-5292 Antecedent denotes Eomes
T9867 3421-3434 Anaphor denotes Both proteins
T9868 3334-3339 Antecedent denotes Eomes
T9869 3344-3349 Antecedent denotes Runx3
T9870 4905-4910 Anaphor denotes which
T9871 4898-4903 Antecedent denotes Runx1
T9872 5119-5121 Anaphor denotes it
R8041 T9867 T9868 boundBy Both proteins,Eomes
R8042 T9867 T9869 boundBy Both proteins,Runx3
R8045 T9870 T9871 boundBy which,Runx1
R8046 T9872 T9873 boundBy it,Eo-VP16
R8048 T9874 T9875 boundBy their,Runx3
R8049 T9874 T9876 boundBy their,Eomes

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T7997 0-5 JJ denotes Runx3
T7998 6-14 NNS denotes controls
T7999 15-23 JJ denotes multiple
T8000 24-31 NNS denotes aspects
T8001 32-34 IN denotes of
T8002 35-38 DT denotes the
T8003 39-42 NNP denotes CTL
T8004 43-58 NN denotes differentiation
T8005 59-66 NN denotes program
T8006 66-67 , denotes ,
T8007 68-70 IN denotes in
T8008 71-75 NN denotes part
T8009 76-83 IN denotes through
T8010 84-93 NN denotes induction
T8011 94-96 IN denotes of
T8012 97-102 NNP denotes Eomes
T8013 103-110 IN denotes Because
T8014 111-116 NNP denotes Runx3
T8015 117-119 VBZ denotes is
T8016 120-126 RB denotes highly
T8017 127-136 VBN denotes expressed
T8018 137-139 IN denotes in
T8019 140-150 JJ denotes peripheral
T8020 151-154 NNP denotes CD8
T8021 154-155 CD denotes +
T8022 156-157 NNP denotes T
T8023 158-163 NNS denotes cells
T8024 163-164 , denotes ,
T8025 165-168 CC denotes and
T8026 169-176 IN denotes because
T8027 177-179 IN denotes of
T8028 180-183 DT denotes the
T8029 184-195 JJ denotes T-bet-Runx3
T8030 196-207 NN denotes cooperation
T8031 208-210 PRP denotes we
T8032 211-219 VBD denotes observed
T8033 220-227 RBR denotes earlier
T8034 228-230 IN denotes in
T8035 231-234 CD denotes CD4
T8036 234-235 CD denotes +
T8037 236-237 NNP denotes T
T8038 238-243 NNS denotes cells
T8039 244-245 -LRB- denotes (
T8040 245-247 CD denotes 15
T8041 247-248 -RRB- denotes )
T8042 248-249 , denotes ,
T8043 250-252 PRP denotes we
T8044 253-261 VBD denotes examined
T8045 262-265 DT denotes the
T8046 266-270 NN denotes role
T8047 271-273 IN denotes of
T8048 274-279 NNP denotes Runx3
T8049 280-282 IN denotes in
T8050 283-291 NN denotes effector
T8051 292-295 NNP denotes CTL
T8052 296-311 NN denotes differentiation
T8053 311-312 . denotes .
T8054 313-315 PRP denotes We
T8055 316-324 VBD denotes isolated
T8056 325-328 NNP denotes CD8
T8057 328-329 NNP denotes +
T8058 330-331 NNP denotes T
T8059 332-337 NNS denotes cells
T8060 338-342 IN denotes from
T8061 343-348 JJ denotes Runx3
T8062 348-349 NN denotes −
T8063 349-350 NN denotes /
T8064 350-351 NN denotes −
T8065 352-353 -LRB- denotes (
T8066 353-355 NNP denotes KO
T8067 355-356 -RRB- denotes )
T8068 357-361 NNS denotes mice
T8069 362-364 IN denotes of
T8070 365-368 DT denotes the
T8071 369-376 JJ denotes outbred
T8072 377-380 NNP denotes ICR
T8073 381-391 NN denotes background
T8074 392-395 CC denotes and
T8075 396-401 PRP$ denotes their
T8076 402-404 NNP denotes WT
T8077 405-410 NNP denotes Runx3
T8078 410-411 VBD denotes +
T8079 411-412 CD denotes /
T8080 412-413 NN denotes +
T8081 414-425 NNS denotes littermates
T8082 426-428 IN denotes by
T8083 429-437 JJ denotes positive
T8084 438-447 NN denotes selection
T8085 448-452 IN denotes with
T8086 453-461 JJ denotes anti-CD8
T8087 462-470 JJ denotes magnetic
T8088 471-476 NNS denotes beads
T8089 477-478 -LRB- denotes (
T8090 478-482 NNS denotes Figs
T8091 482-483 . denotes .
T8092 484-486 CD denotes S1
T8093 487-490 CC denotes and
T8094 491-493 CD denotes S2
T8095 493-494 , denotes ,
T8096 495-504 JJ denotes available
T8097 505-507 IN denotes at
T8098 508-560 NNP denotes http://www.jem.org/cgi/content/full/jem.20081242/DC1
T8099 560-561 -RRB- denotes )
T8100 561-562 . denotes .
T8101 563-573 RB denotes Strikingly
T8102 573-574 , denotes ,
T8103 575-580 JJ denotes Runx3
T8104 580-581 FW denotes −
T8105 581-582 FW denotes /
T8106 582-583 FW denotes −
T8107 584-587 FW denotes CD8
T8108 587-588 FW denotes +
T8109 589-590 FW denotes T
T8110 591-596 NNS denotes cells
T8111 597-601 VBD denotes were
T8112 602-610 RB denotes strongly
T8113 611-619 VBN denotes impaired
T8114 620-622 IN denotes in
T8115 623-628 PRP$ denotes their
T8116 629-636 NN denotes ability
T8117 637-639 TO denotes to
T8118 640-653 VB denotes differentiate
T8119 654-658 IN denotes into
T8120 659-667 NN denotes effector
T8121 668-672 NNS denotes CTLs
T8122 672-673 , denotes ,
T8123 674-676 IN denotes as
T8124 677-683 VBN denotes judged
T8125 684-686 IN denotes by
T8126 687-697 NN denotes expression
T8127 698-700 IN denotes of
T8128 701-709 NN denotes perforin
T8129 709-710 , denotes ,
T8130 711-719 NN denotes granzyme
T8131 720-721 NNP denotes B
T8132 721-722 , denotes ,
T8133 723-726 CC denotes and
T8134 727-732 NNP denotes IFN-γ
T8135 733-734 -LRB- denotes (
T8136 734-738 NNP denotes Fig.
T8137 739-740 CD denotes 3
T8138 740-741 -RRB- denotes )
T8139 741-742 . denotes .
T8140 743-751 VBN denotes Compared
T8141 752-756 IN denotes with
T8142 757-759 NNP denotes WT
T8143 760-761 NNP denotes T
T8144 762-767 NNS denotes cells
T8145 767-768 , denotes ,
T8146 769-777 NN denotes perforin
T8147 778-782 NNP denotes mRNA
T8148 783-786 CC denotes and
T8149 787-794 NN denotes protein
T8150 795-805 NN denotes expression
T8151 806-810 VBD denotes were
T8152 811-822 RB denotes essentially
T8153 823-835 JJ denotes undetectable
T8154 836-838 IN denotes in
T8155 839-844 NNP denotes Runx3
T8156 844-845 NNP denotes −
T8157 845-846 VBD denotes /
T8158 846-847 CD denotes −
T8159 848-849 NNP denotes T
T8160 850-855 NNS denotes cells
T8161 856-858 IN denotes at
T8162 859-862 NN denotes day
T8163 863-864 CD denotes 6
T8164 865-867 IN denotes of
T8165 868-875 NN denotes culture
T8166 876-877 -LRB- denotes (
T8167 877-881 JJ denotes Fig.
T8168 882-883 CD denotes 3
T8169 883-884 , denotes ,
T8170 885-886 DT denotes A
T8171 887-890 CC denotes and
T8172 891-892 NNP denotes B
T8173 892-893 -RRB- denotes )
T8174 893-894 . denotes .
T8175 895-900 JJ denotes Runx3
T8176 900-901 FW denotes −
T8177 901-902 FW denotes /
T8178 902-903 FW denotes −
T8179 904-905 FW denotes T
T8180 906-911 NNS denotes cells
T8181 912-916 RB denotes also
T8182 917-920 VBD denotes had
T8183 921-923 DT denotes no
T8184 924-934 JJ denotes detectable
T8185 935-940 NNP denotes Eomes
T8186 941-951 NN denotes expression
T8187 951-952 : denotes ;
T8188 953-955 IN denotes in
T8189 956-964 NN denotes contrast
T8190 964-965 , denotes ,
T8191 966-971 NN denotes T-bet
T8192 972-982 NN denotes expression
T8193 983-986 VBD denotes was
T8194 987-997 VBN denotes unimpaired
T8195 998-999 -LRB- denotes (
T8196 999-1003 JJ denotes Fig.
T8197 1004-1005 CD denotes 3
T8198 1006-1007 NN denotes A
T8199 1007-1008 -RRB- denotes )
T8200 1008-1009 . denotes .
T8201 1010-1021 RB denotes Furthermore
T8202 1021-1022 , denotes ,
T8203 1023-1028 NNP denotes Runx3
T8204 1029-1032 VBD denotes was
T8205 1033-1041 VBN denotes required
T8206 1042-1045 IN denotes for
T8207 1046-1053 JJ denotes maximal
T8208 1054-1064 NN denotes production
T8209 1065-1067 IN denotes of
T8210 1068-1073 NNP denotes IFN-γ
T8211 1073-1074 , denotes ,
T8212 1075-1078 CC denotes but
T8213 1079-1082 RB denotes not
T8214 1083-1086 NNP denotes TNF
T8215 1087-1089 CC denotes or
T8216 1090-1094 NNP denotes IL-2
T8217 1094-1095 , denotes ,
T8218 1096-1098 IN denotes by
T8219 1099-1102 CD denotes CD8
T8220 1102-1103 CD denotes +
T8221 1104-1105 NNP denotes T
T8222 1106-1111 NNS denotes cells
T8223 1112-1124 VBD denotes restimulated
T8224 1125-1127 IN denotes at
T8225 1128-1131 NN denotes day
T8226 1132-1133 CD denotes 6
T8227 1134-1135 -LRB- denotes (
T8228 1135-1139 NN denotes Fig.
T8229 1140-1141 CD denotes 3
T8230 1142-1143 NNP denotes C
T8231 1143-1144 -RRB- denotes )
T8232 1144-1145 . denotes .
T8233 2284-2286 PRP denotes We
T8234 2287-2297 RB denotes previously
T8235 2298-2306 VBD denotes reported
T8236 2307-2311 IN denotes that
T8237 2312-2315 CD denotes Th1
T8238 2316-2320 NN denotes cell
T8239 2321-2336 NN denotes differentiation
T8240 2337-2340 VBD denotes was
T8241 2341-2350 VBN denotes regulated
T8242 2351-2358 IN denotes through
T8243 2359-2360 DT denotes a
T8244 2361-2373 JJ denotes feed-forward
T8245 2374-2378 NN denotes loop
T8246 2379-2381 IN denotes in
T8247 2382-2387 WDT denotes which
T8248 2388-2393 NNP denotes T-bet
T8249 2394-2396 VBZ denotes is
T8250 2397-2409 JJ denotes up-regulated
T8251 2410-2415 RB denotes early
T8252 2416-2419 CC denotes and
T8253 2420-2427 VBZ denotes induces
T8254 2428-2433 NNP denotes Runx3
T8255 2433-2434 , denotes ,
T8256 2435-2440 IN denotes after
T8257 2441-2446 WDT denotes which
T8258 2447-2452 NNP denotes T-bet
T8259 2453-2456 CC denotes and
T8260 2457-2462 NNP denotes Runx3
T8261 2463-2472 VBP denotes cooperate
T8262 2473-2475 TO denotes to
T8263 2476-2482 VB denotes induce
T8264 2483-2488 NNP denotes IFN-γ
T8265 2489-2492 CC denotes and
T8266 2493-2500 NN denotes silence
T8267 2501-2505 NN denotes IL-4
T8268 2505-2506 , denotes ,
T8269 2507-2511 RB denotes thus
T8270 2512-2521 VBG denotes promoting
T8271 2522-2528 JJ denotes stable
T8272 2529-2544 NN denotes differentiation
T8273 2545-2551 IN denotes toward
T8274 2552-2555 DT denotes the
T8275 2556-2559 JJ denotes Th1
T8276 2560-2567 NN denotes lineage
T8277 2568-2569 -LRB- denotes (
T8278 2569-2571 CD denotes 15
T8279 2571-2572 , denotes ,
T8280 2573-2575 CD denotes 22
T8281 2575-2576 -RRB- denotes )
T8282 2576-2577 . denotes .
T8283 2578-2585 IN denotes Because
T8284 2586-2587 -LRB- denotes (
T8285 2587-2588 DT denotes a
T8286 2588-2589 -RRB- denotes )
T8287 2590-2595 JJ denotes Runx3
T8288 2596-2604 VBD denotes appeared
T8289 2605-2614 JJ denotes necessary
T8290 2615-2618 IN denotes for
T8291 2619-2624 NNP denotes Eomes
T8292 2625-2634 NN denotes induction
T8293 2635-2636 -LRB- denotes (
T8294 2636-2640 JJ denotes Fig.
T8295 2641-2642 CD denotes 3
T8296 2643-2644 NN denotes A
T8297 2644-2645 -RRB- denotes )
T8298 2645-2646 , denotes ,
T8299 2647-2648 -LRB- denotes (
T8300 2648-2649 NN denotes b
T8301 2649-2650 -RRB- denotes )
T8302 2651-2654 DT denotes the
T8303 2655-2663 NNS denotes kinetics
T8304 2664-2666 IN denotes of
T8305 2667-2672 NNP denotes Eomes
T8306 2673-2683 NN denotes expression
T8307 2684-2694 VBD denotes paralleled
T8308 2695-2700 DT denotes those
T8309 2701-2703 IN denotes of
T8310 2704-2712 NN denotes perforin
T8311 2713-2723 NN denotes expression
T8312 2724-2725 -LRB- denotes (
T8313 2725-2729 FW denotes Fig.
T8314 2730-2731 LS denotes 2
T8315 2731-2732 -RRB- denotes )
T8316 2732-2733 , denotes ,
T8317 2734-2737 CC denotes and
T8318 2738-2739 -LRB- denotes (
T8319 2739-2740 NN denotes c
T8320 2740-2741 -RRB- denotes )
T8321 2742-2756 NN denotes overexpression
T8322 2757-2759 IN denotes of
T8323 2760-2767 NN denotes Eo-VP16
T8324 2768-2770 IN denotes in
T8325 2771-2777 CC denotes either
T8326 2778-2780 NNP denotes WT
T8327 2781-2783 CC denotes or
T8328 2784-2789 NNP denotes T-bet
T8329 2790-2799 JJ denotes deficient
T8330 2800-2801 NNP denotes T
T8331 2802-2807 NNS denotes cells
T8332 2808-2811 VBD denotes led
T8333 2812-2814 TO denotes to
T8334 2815-2817 DT denotes an
T8335 2818-2826 NN denotes increase
T8336 2827-2829 IN denotes in
T8337 2830-2834 DT denotes both
T8338 2835-2843 NN denotes perforin
T8339 2844-2847 CC denotes and
T8340 2848-2853 JJ denotes IFN-γ
T8341 2854-2864 NN denotes expression
T8342 2865-2866 -LRB- denotes (
T8343 2866-2870 JJ denotes Fig.
T8344 2871-2872 CD denotes 2
T8345 2872-2873 , denotes ,
T8346 2874-2875 NNP denotes B
T8347 2876-2879 CC denotes and
T8348 2880-2881 NNP denotes D
T8349 2881-2882 -RRB- denotes )
T8350 2882-2883 , denotes ,
T8351 2884-2886 PRP denotes we
T8352 2887-2892 VBD denotes asked
T8353 2893-2900 IN denotes whether
T8354 2901-2904 NNP denotes CTL
T8355 2905-2920 NN denotes differentiation
T8356 2921-2924 VBD denotes was
T8357 2925-2929 RB denotes also
T8358 2930-2941 RB denotes potentially
T8359 2942-2951 VBN denotes regulated
T8360 2952-2954 IN denotes by
T8361 2955-2956 DT denotes a
T8362 2957-2969 JJ denotes feed-forward
T8363 2970-2974 NN denotes loop
T8364 2975-2984 VBG denotes involving
T8365 2985-2990 DT denotes these
T8366 2991-2995 JJ denotes same
T8367 2996-2999 CD denotes two
T8368 3000-3007 NNS denotes classes
T8369 3008-3010 IN denotes of
T8370 3011-3015 NNP denotes Runx
T8371 3016-3019 CC denotes and
T8372 3020-3025 NNP denotes T-box
T8373 3026-3039 NN denotes transcription
T8374 3040-3047 NNS denotes factors
T8375 3047-3048 . denotes .
T8376 3049-3061 RB denotes Specifically
T8377 3061-3062 , denotes ,
T8378 3063-3065 PRP denotes we
T8379 3066-3071 VBD denotes asked
T8380 3072-3079 IN denotes whether
T8381 3080-3085 NNP denotes Runx3
T8382 3085-3086 , denotes ,
T8383 3087-3092 WDT denotes which
T8384 3093-3096 VBD denotes was
T8385 3097-3106 JJ denotes necessary
T8386 3107-3110 IN denotes for
T8387 3111-3116 NNP denotes Eomes
T8388 3117-3126 NN denotes induction
T8389 3126-3127 , denotes ,
T8390 3128-3132 RB denotes then
T8391 3133-3143 VBD denotes cooperated
T8392 3144-3148 IN denotes with
T8393 3149-3154 NNP denotes Eomes
T8394 3155-3157 TO denotes to
T8395 3158-3166 VB denotes regulate
T8396 3167-3180 NN denotes transcription
T8397 3181-3183 IN denotes of
T8398 3184-3187 DT denotes the
T8399 3188-3196 NN denotes effector
T8400 3197-3200 NNP denotes CTL
T8401 3201-3208 NNS denotes markers
T8402 3209-3217 VBP denotes perforin
T8403 3217-3218 , denotes ,
T8404 3219-3224 NNP denotes IFN-γ
T8405 3224-3225 , denotes ,
T8406 3226-3229 CC denotes and
T8407 3230-3238 NN denotes granzyme
T8408 3239-3241 NNP denotes B.
T8409 3242-3244 TO denotes To
T8410 3245-3249 VB denotes test
T8411 3250-3254 DT denotes this
T8412 3255-3265 NN denotes hypothesis
T8413 3265-3266 , denotes ,
T8414 3267-3269 PRP denotes we
T8415 3270-3274 VBD denotes used
T8416 3275-3284 NN denotes chromatin
T8417 3285-3304 NN denotes immunoprecipitation
T8418 3305-3306 -LRB- denotes (
T8419 3306-3310 NNP denotes ChIP
T8420 3310-3311 -RRB- denotes )
T8421 3312-3318 VBZ denotes assays
T8422 3319-3321 TO denotes to
T8423 3322-3325 VB denotes ask
T8424 3326-3333 IN denotes whether
T8425 3334-3339 NNP denotes Eomes
T8426 3340-3343 CC denotes and
T8427 3344-3349 NNP denotes Runx3
T8428 3350-3355 VBD denotes bound
T8429 3356-3366 JJ denotes regulatory
T8430 3367-3374 NNS denotes regions
T8431 3375-3377 IN denotes of
T8432 3378-3381 DT denotes the
T8433 3382-3386 NNP denotes Prf1
T8434 3386-3387 , denotes ,
T8435 3388-3392 NNP denotes Ifng
T8436 3392-3393 , denotes ,
T8437 3394-3397 CC denotes and
T8438 3398-3402 NNP denotes Gzmb
T8439 3403-3408 NNS denotes genes
T8440 3409-3410 -LRB- denotes (
T8441 3410-3414 NN denotes Fig.
T8442 3415-3416 CD denotes 3
T8443 3417-3418 NNP denotes D
T8444 3418-3419 -RRB- denotes )
T8445 3419-3420 . denotes .
T8446 3421-3425 DT denotes Both
T8447 3426-3434 NNS denotes proteins
T8448 3435-3445 VBN denotes associated
T8449 3446-3450 IN denotes with
T8450 3451-3455 NN denotes gene
T8451 3456-3466 JJ denotes regulatory
T8452 3467-3474 NNS denotes regions
T8453 3475-3477 IN denotes in
T8454 3478-3492 JJ denotes differentiated
T8455 3493-3497 NNS denotes CTLs
T8456 3497-3498 . denotes .
T8457 3499-3504 JJ denotes Runx3
T8458 3505-3510 VBN denotes bound
T8459 3511-3513 TO denotes to
T8460 3514-3517 DT denotes the
T8461 3518-3522 NNP denotes Prf1
T8462 3523-3526 CC denotes and
T8463 3527-3531 NNP denotes Gzmb
T8464 3532-3545 NN denotes transcription
T8465 3546-3551 NN denotes start
T8466 3552-3557 NNS denotes sites
T8467 3558-3559 -LRB- denotes (
T8468 3559-3562 NNP denotes TSS
T8469 3562-3563 -RRB- denotes )
T8470 3563-3564 : denotes ;
T8471 3565-3567 TO denotes to
T8472 3568-3569 DT denotes a
T8473 3570-3575 VBN denotes known
T8474 3576-3580 NN denotes IL-2
T8475 3581-3591 JJ denotes responsive
T8476 3592-3600 NN denotes enhancer
T8477 3601-3608 VBN denotes located
T8478 3609-3613 IN denotes near
T8479 3614-3615 CD denotes −
T8480 3615-3616 CD denotes 1
T8481 3617-3619 NN denotes kb
T8482 3620-3622 IN denotes of
T8483 3623-3626 DT denotes the
T8484 3627-3631 NNP denotes Prf1
T8485 3632-3636 NN denotes gene
T8486 3637-3638 -LRB- denotes (
T8487 3638-3640 CD denotes 23
T8488 3640-3641 -RRB- denotes )
T8489 3641-3642 : denotes ;
T8490 3643-3645 TO denotes to
T8491 3646-3649 DT denotes the
T8492 3650-3656 JJ denotes distal
T8493 3657-3669 JJ denotes CTL-specific
T8494 3670-3675 NNP denotes DNase
T8495 3676-3677 PRP denotes I
T8496 3678-3692 VBP denotes hypersensitive
T8497 3693-3697 NN denotes site
T8498 3698-3699 CD denotes 9
T8499 3700-3702 IN denotes in
T8500 3703-3706 DT denotes the
T8501 3707-3711 JJ denotes Prf1
T8502 3712-3717 NN denotes locus
T8503 3718-3719 -LRB- denotes (
T8504 3719-3721 CD denotes 24
T8505 3721-3722 -RRB- denotes )
T8506 3722-3723 : denotes ;
T8507 3724-3726 TO denotes to
T8508 3727-3730 DT denotes the
T8509 3731-3735 NNP denotes Ifng
T8510 3736-3744 NN denotes promoter
T8511 3745-3749 IN denotes near
T8512 3750-3753 DT denotes the
T8513 3754-3757 NNP denotes TSS
T8514 3757-3758 , denotes ,
T8515 3759-3761 IN denotes as
T8516 3762-3772 RB denotes previously
T8517 3773-3781 VBN denotes reported
T8518 3782-3785 IN denotes for
T8519 3786-3789 JJ denotes Th1
T8520 3790-3795 NNS denotes cells
T8521 3796-3797 -LRB- denotes (
T8522 3797-3799 CD denotes 10
T8523 3799-3800 -RRB- denotes )
T8524 3800-3801 : denotes ;
T8525 3802-3805 CC denotes and
T8526 3806-3808 TO denotes to
T8527 3809-3816 JJ denotes several
T8528 3817-3822 NNP denotes DNase
T8529 3823-3824 PRP denotes I
T8530 3825-3839 VBP denotes hypersensitive
T8531 3840-3845 NNS denotes sites
T8532 3846-3848 IN denotes in
T8533 3849-3852 DT denotes the
T8534 3853-3857 NNP denotes Ifng
T8535 3858-3863 NN denotes locus
T8536 3864-3865 -LRB- denotes (
T8537 3865-3869 JJ denotes Fig.
T8538 3870-3871 CD denotes 3
T8539 3872-3873 NNP denotes D
T8540 3874-3877 CC denotes and
T8541 3878-3881 RB denotes not
T8542 3882-3890 VBN denotes depicted
T8543 3890-3891 -RRB- denotes )
T8544 3892-3893 -LRB- denotes (
T8545 3893-3895 CD denotes 25
T8546 3895-3896 -RRB- denotes )
T8547 3896-3897 . denotes .
T8548 3898-3903 NNS denotes Eomes
T8549 3904-3909 VBN denotes bound
T8550 3910-3919 RB denotes primarily
T8551 3920-3922 TO denotes to
T8552 3923-3926 DT denotes the
T8553 3927-3931 NNP denotes Prf1
T8554 3932-3935 NNP denotes TSS
T8555 3936-3939 CC denotes and
T8556 3940-3943 DT denotes the
T8557 3944-3945 NN denotes −
T8558 3945-3946 CD denotes 1
T8559 3947-3949 NN denotes kb
T8560 3950-3958 NN denotes enhancer
T8561 3958-3959 : denotes ;
T8562 3960-3964 DT denotes this
T8563 3965-3972 JJ denotes binding
T8564 3973-3976 VBD denotes was
T8565 3977-3990 RB denotes substantially
T8566 3991-3998 JJR denotes greater
T8567 3999-4003 IN denotes than
T8568 4004-4008 DT denotes that
T8569 4009-4017 VBD denotes observed
T8570 4018-4020 IN denotes at
T8571 4021-4024 DT denotes the
T8572 4025-4033 NN denotes promoter
T8573 4034-4036 IN denotes of
T8574 4037-4040 DT denotes the
T8575 4041-4046 JJ denotes Il2rb
T8576 4047-4051 NN denotes gene
T8577 4051-4052 , denotes ,
T8578 4053-4054 DT denotes a
T8579 4055-4060 VBN denotes known
T8580 4061-4067 JJ denotes direct
T8581 4068-4074 NN denotes target
T8582 4075-4077 IN denotes of
T8583 4078-4083 NNP denotes Eomes
T8584 4084-4085 -LRB- denotes (
T8585 4085-4086 CD denotes 8
T8586 4086-4087 -RRB- denotes )
T8587 4087-4088 , denotes ,
T8588 4089-4092 CC denotes and
T8589 4093-4103 JJ denotes comparable
T8590 4104-4106 TO denotes to
T8591 4107-4111 DT denotes that
T8592 4112-4120 VBD denotes observed
T8593 4121-4123 IN denotes at
T8594 4124-4127 DT denotes the
T8595 4128-4132 NNP denotes Ifng
T8596 4133-4136 NNP denotes TSS
T8597 4136-4137 , denotes ,
T8598 4138-4139 DT denotes a
T8599 4140-4145 VBN denotes known
T8600 4146-4152 NN denotes target
T8601 4153-4155 IN denotes of
T8602 4156-4161 NN denotes T-box
T8603 4162-4170 NNS denotes proteins
T8604 4171-4173 IN denotes in
T8605 4174-4178 DT denotes both
T8606 4179-4182 CD denotes Th1
T8607 4183-4186 CC denotes and
T8608 4187-4190 CD denotes CD8
T8609 4190-4191 CD denotes +
T8610 4192-4193 NNP denotes T
T8611 4194-4199 NNS denotes cells
T8612 4200-4201 -LRB- denotes (
T8613 4201-4205 NN denotes Fig.
T8614 4206-4207 CD denotes 3
T8615 4208-4209 NNP denotes D
T8616 4209-4210 -RRB- denotes )
T8617 4211-4212 -LRB- denotes (
T8618 4212-4214 CD denotes 17
T8619 4214-4215 -RRB- denotes )
T8620 4215-4216 . denotes .
T8621 4217-4219 TO denotes To
T8622 4220-4229 VB denotes determine
T8623 4230-4237 IN denotes whether
T8624 4238-4243 JJ denotes Runx3
T8625 4244-4254 VBN denotes controlled
T8626 4255-4258 DT denotes the
T8627 4259-4269 NN denotes expression
T8628 4270-4272 IN denotes of
T8629 4273-4276 NNP denotes CTL
T8630 4277-4285 NN denotes effector
T8631 4286-4291 NNS denotes genes
T8632 4292-4299 IN denotes through
T8633 4300-4303 PRP$ denotes its
T8634 4304-4313 NN denotes induction
T8635 4314-4316 IN denotes of
T8636 4317-4322 NNP denotes Eomes
T8637 4322-4323 , denotes ,
T8638 4324-4326 PRP denotes we
T8639 4327-4339 RB denotes retrovirally
T8640 4340-4349 VBD denotes expressed
T8641 4350-4355 NNP denotes Runx3
T8642 4356-4359 CC denotes and
T8643 4360-4367 NNP denotes Eo-VP16
T8644 4368-4370 IN denotes in
T8645 4371-4374 NNP denotes CD8
T8646 4374-4375 NNP denotes +
T8647 4376-4377 NNP denotes T
T8648 4378-4383 NNS denotes cells
T8649 4384-4388 IN denotes from
T8650 4389-4394 JJ denotes Runx3
T8651 4394-4395 NN denotes −
T8652 4395-4396 NN denotes /
T8653 4396-4397 NN denotes −
T8654 4398-4402 NNS denotes mice
T8655 4402-4403 . denotes .
T8656 4404-4411 IN denotes Because
T8657 4412-4414 IN denotes of
T8658 4415-4418 DT denotes the
T8659 4419-4426 JJ denotes limited
T8660 4427-4433 NN denotes number
T8661 4434-4436 IN denotes of
T8662 4437-4440 CD denotes CD8
T8663 4440-4441 CD denotes +
T8664 4442-4443 NNP denotes T
T8665 4444-4449 NNS denotes cells
T8666 4450-4452 IN denotes in
T8667 4453-4458 DT denotes these
T8668 4459-4463 NNS denotes mice
T8669 4463-4464 , denotes ,
T8670 4465-4468 CC denotes and
T8671 4469-4476 IN denotes because
T8672 4477-4479 PRP denotes we
T8673 4480-4483 VBD denotes saw
T8674 4484-4486 DT denotes no
T8675 4487-4497 NN denotes difference
T8676 4498-4505 IN denotes between
T8677 4506-4511 NNP denotes Runx3
T8678 4511-4512 FW denotes −
T8679 4512-4513 FW denotes /
T8680 4513-4514 FW denotes −
T8681 4515-4518 FW denotes CD8
T8682 4518-4519 FW denotes +
T8683 4519-4522 FW denotes CD4
T8684 4522-4523 FW denotes −
T8685 4524-4526 NNP denotes SP
T8686 4527-4530 CC denotes and
T8687 4531-4534 NNP denotes CD8
T8688 4534-4535 NNP denotes +
T8689 4535-4538 NNP denotes CD4
T8690 4538-4539 NNP denotes +
T8691 4540-4542 NNP denotes DP
T8692 4543-4548 NNS denotes cells
T8693 4549-4551 IN denotes in
T8694 4552-4555 PRP$ denotes our
T8695 4556-4564 JJ denotes previous
T8696 4565-4576 NNS denotes experiments
T8697 4576-4577 , denotes ,
T8698 4578-4580 PRP denotes we
T8699 4581-4585 VBD denotes used
T8700 4586-4591 JJ denotes total
T8701 4592-4597 JJ denotes Runx3
T8702 4597-4598 NN denotes −
T8703 4598-4599 FW denotes /
T8704 4599-4600 FW denotes −
T8705 4601-4604 FW denotes CD8
T8706 4604-4605 FW denotes +
T8707 4606-4607 FW denotes T
T8708 4608-4613 NNS denotes cells
T8709 4614-4621 IN denotes without
T8710 4622-4629 JJ denotes further
T8711 4630-4643 NN denotes fractionation
T8712 4644-4646 IN denotes as
T8713 4647-4657 NNS denotes recipients
T8714 4658-4661 IN denotes for
T8715 4662-4672 JJ denotes retroviral
T8716 4673-4685 NN denotes transduction
T8717 4685-4686 . denotes .
T8718 4687-4701 NN denotes Reconstitution
T8719 4702-4704 IN denotes of
T8720 4705-4710 NNP denotes Runx3
T8721 4710-4711 FW denotes −
T8722 4711-4712 FW denotes /
T8723 4712-4713 FW denotes −
T8724 4714-4717 FW denotes CD8
T8725 4717-4718 FW denotes +
T8726 4719-4720 FW denotes T
T8727 4721-4726 NNS denotes cells
T8728 4727-4731 IN denotes with
T8729 4732-4737 JJ denotes Runx3
T8730 4738-4746 VBN denotes restored
T8731 4747-4757 NN denotes expression
T8732 4758-4760 IN denotes of
T8733 4761-4766 NNP denotes Eomes
T8734 4767-4769 RB denotes as
T8735 4770-4774 RB denotes well
T8736 4775-4777 IN denotes as
T8737 4778-4786 NN denotes perforin
T8738 4786-4787 , denotes ,
T8739 4788-4796 NN denotes granzyme
T8740 4797-4798 NNP denotes B
T8741 4798-4799 , denotes ,
T8742 4800-4803 CC denotes and
T8743 4804-4809 NNP denotes IFN-γ
T8744 4810-4811 -LRB- denotes (
T8745 4811-4815 NNP denotes Fig.
T8746 4816-4817 CD denotes 4
T8747 4817-4818 , denotes ,
T8748 4819-4820 DT denotes A
T8749 4821-4824 CC denotes and
T8750 4825-4826 NNP denotes B
T8751 4826-4827 -RRB- denotes )
T8752 4827-4828 . denotes .
T8753 4829-4831 IN denotes In
T8754 4832-4840 NN denotes addition
T8755 4840-4841 , denotes ,
T8756 4842-4847 NNP denotes Runx3
T8757 4847-4848 VBD denotes −
T8758 4848-4849 CD denotes /
T8759 4849-4850 CD denotes −
T8760 4851-4852 NNP denotes T
T8761 4853-4858 NNS denotes cells
T8762 4859-4865 VBD denotes showed
T8763 4866-4867 DT denotes a
T8764 4868-4880 JJ denotes compensatory
T8765 4881-4894 NN denotes up-regulation
T8766 4895-4897 IN denotes of
T8767 4898-4903 NNP denotes Runx1
T8768 4903-4904 , denotes ,
T8769 4905-4910 WDT denotes which
T8770 4911-4914 VBD denotes was
T8771 4915-4925 VBN denotes suppressed
T8772 4926-4930 IN denotes upon
T8773 4931-4945 NN denotes reconstitution
T8774 4946-4950 IN denotes with
T8775 4951-4956 NNP denotes Runx3
T8776 4956-4957 , denotes ,
T8777 4958-4968 VBG denotes indicating
T8778 4969-4973 IN denotes that
T8779 4974-4979 NNP denotes Runx1
T8780 4980-4982 VBZ denotes is
T8781 4983-4984 DT denotes a
T8782 4985-4991 NN denotes target
T8783 4992-4994 IN denotes of
T8784 4995-5005 NN denotes repression
T8785 5006-5008 IN denotes by
T8786 5009-5014 NNP denotes Runx3
T8787 5014-5015 . denotes .
T8788 5016-5023 RB denotes Notably
T8789 5023-5024 , denotes ,
T8790 5025-5032 NN denotes Eo-VP16
T8791 5033-5036 VBD denotes did
T8792 5037-5040 RB denotes not
T8793 5041-5052 JJ denotes up-regulate
T8794 5053-5061 NN denotes perforin
T8795 5062-5072 NN denotes expression
T8796 5073-5077 WRB denotes when
T8797 5078-5087 VBN denotes expressed
T8798 5088-5090 IN denotes in
T8799 5091-5096 NNP denotes Runx3
T8800 5096-5097 NNP denotes −
T8801 5097-5098 VBD denotes /
T8802 5098-5099 CD denotes −
T8803 5100-5105 NNS denotes cells
T8804 5105-5106 , denotes ,
T8805 5107-5111 RB denotes even
T8806 5112-5118 IN denotes though
T8807 5119-5121 PRP denotes it
T8808 5122-5130 VBD denotes restored
T8809 5131-5134 DT denotes the
T8810 5135-5143 NN denotes capacity
T8811 5144-5146 TO denotes to
T8812 5147-5153 VB denotes induce
T8813 5154-5159 JJ denotes IFN-γ
T8814 5160-5170 NN denotes expression
T8815 5171-5175 IN denotes upon
T8816 5176-5179 NNP denotes TCR
T8817 5180-5193 NN denotes restimulation
T8818 5194-5195 -LRB- denotes (
T8819 5195-5199 JJ denotes Fig.
T8820 5200-5201 CD denotes 4
T8821 5201-5202 , denotes ,
T8822 5203-5204 DT denotes A
T8823 5205-5208 CC denotes and
T8824 5209-5210 NNP denotes B
T8825 5210-5211 -RRB- denotes )
T8826 5211-5212 . denotes .
T8827 5213-5217 DT denotes This
T8828 5218-5224 NN denotes result
T8829 5225-5233 VBZ denotes suggests
T8830 5234-5242 RB denotes strongly
T8831 5243-5247 IN denotes that
T8832 5248-5256 JJ denotes perforin
T8833 5257-5267 NN denotes expression
T8834 5268-5276 VBZ denotes requires
T8835 5277-5282 NNP denotes Runx3
T8836 5283-5286 CC denotes and
T8837 5287-5292 NNP denotes Eomes
T8838 5292-5293 . denotes .
T8839 6965-6967 IN denotes As
T8840 6968-6976 VBN denotes expected
T8841 6977-6981 IN denotes from
T8842 6982-6987 PRP$ denotes their
T8843 6988-6994 NN denotes defect
T8844 6995-6997 IN denotes in
T8845 6998-7006 NN denotes perforin
T8846 7007-7010 CC denotes and
T8847 7011-7019 NN denotes granzyme
T8848 7020-7021 NNP denotes B
T8849 7022-7032 NN denotes expression
T8850 7032-7033 , denotes ,
T8851 7034-7039 JJ denotes Runx3
T8852 7039-7040 FW denotes −
T8853 7040-7041 FW denotes /
T8854 7041-7042 FW denotes −
T8855 7043-7046 FW denotes CD8
T8856 7046-7047 FW denotes +
T8857 7048-7049 FW denotes T
T8858 7050-7055 NNS denotes cells
T8859 7056-7062 VBD denotes showed
T8860 7063-7072 JJ denotes defective
T8861 7073-7082 JJ denotes cytolytic
T8862 7083-7091 NN denotes activity
T8863 7092-7094 IN denotes in
T8864 7095-7096 DT denotes a
T8865 7097-7102 JJ denotes mixed
T8866 7103-7113 NN denotes lymphocyte
T8867 7114-7122 NN denotes reaction
T8868 7123-7124 -LRB- denotes (
T8869 7124-7126 CD denotes 12
T8870 7126-7127 -RRB- denotes )
T8871 7127-7128 . denotes .
T8872 7129-7136 RB denotes However
T8873 7136-7137 , denotes ,
T8874 7138-7152 JJ denotes TCR-stimulated
T8875 7153-7158 JJ denotes Runx3
T8876 7158-7159 NN denotes −
T8877 7159-7160 VBD denotes /
T8878 7160-7161 CD denotes −
T8879 7162-7165 CD denotes CD8
T8880 7165-7166 NN denotes +
T8881 7167-7172 NNS denotes cells
T8882 7173-7177 VBD denotes were
T8883 7178-7180 IN denotes as
T8884 7181-7190 JJ denotes effective
T8885 7191-7193 IN denotes as
T8886 7194-7196 NNP denotes WT
T8887 7197-7202 NNS denotes cells
T8888 7203-7205 IN denotes in
T8889 7206-7213 VBG denotes killing
T8890 7214-7219 NN denotes tumor
T8891 7220-7225 NNS denotes cells
T8892 7226-7228 IN denotes in
T8893 7229-7230 DT denotes a
T8894 7231-7241 VBN denotes redirected
T8895 7242-7245 NNP denotes CTL
T8896 7246-7251 NN denotes assay
T8897 7252-7253 -LRB- denotes (
T8898 7253-7255 CD denotes 12
T8899 7255-7256 -RRB- denotes )
T8900 7256-7257 . denotes .
T8901 7258-7269 RB denotes Furthermore
T8902 7269-7270 , denotes ,
T8903 7271-7274 NNP denotes CD8
T8904 7274-7275 NNP denotes +
T8905 7276-7281 NNS denotes cells
T8906 7282-7286 IN denotes from
T8907 7287-7290 DT denotes the
T8908 7291-7301 JJ denotes peritoneal
T8909 7302-7308 NN denotes cavity
T8910 7309-7311 IN denotes of
T8911 7312-7317 NNP denotes Runx3
T8912 7317-7318 NNP denotes −
T8913 7318-7319 VBD denotes /
T8914 7319-7320 CD denotes −
T8915 7321-7325 NNS denotes mice
T8916 7326-7335 VBN denotes immunized
T8917 7336-7340 IN denotes with
T8918 7341-7348 JJ denotes certain
T8919 7349-7354 NN denotes tumor
T8920 7355-7360 NNS denotes cells
T8921 7361-7372 RB denotes effectively
T8922 7373-7379 VBD denotes killed
T8923 7380-7385 DT denotes these
T8924 7386-7393 NNS denotes targets
T8925 7394-7395 -LRB- denotes (
T8926 7395-7397 CD denotes 13
T8927 7397-7398 -RRB- denotes )
T8928 7398-7399 . denotes .
T8929 7400-7409 RB denotes Therefore
T8930 7409-7410 , denotes ,
T8931 7411-7419 IN denotes although
T8932 7420-7430 NN denotes activation
T8933 7431-7433 IN denotes of
T8934 7434-7437 DT denotes the
T8935 7438-7455 NN denotes perforin/granzyme
T8936 7456-7457 NNP denotes B
T8937 7458-7467 NN denotes machinery
T8938 7468-7470 VBZ denotes is
T8939 7471-7480 JJ denotes defective
T8940 7481-7483 IN denotes in
T8941 7484-7489 NNP denotes Runx3
T8942 7489-7490 NNP denotes −
T8943 7490-7491 VBD denotes /
T8944 7491-7492 CD denotes −
T8945 7493-7496 CD denotes CD8
T8946 7496-7497 NN denotes +
T8947 7498-7503 NNS denotes cells
T8948 7503-7504 , denotes ,
T8949 7505-7510 DT denotes these
T8950 7511-7516 NNS denotes cells
T8951 7517-7520 VBP denotes are
T8952 7521-7524 RB denotes not
T8953 7525-7533 RB denotes entirely
T8954 7534-7540 JJ denotes devoid
T8955 7541-7543 IN denotes of
T8956 7544-7553 JJ denotes cytolytic
T8957 7554-7562 NN denotes activity
T8958 7563-7566 CC denotes and
T8959 7567-7572 MD denotes could
T8960 7573-7578 RB denotes still
T8961 7579-7590 RB denotes effectively
T8962 7591-7595 VB denotes kill
T8963 7596-7603 NNS denotes targets
T8964 7603-7604 , denotes ,
T8965 7605-7613 RB denotes possibly
T8966 7614-7616 IN denotes by
T8967 7617-7628 JJ denotes alternative
T8968 7629-7639 NNS denotes mechanisms
T8969 7640-7644 JJ denotes such
T8970 7645-7647 IN denotes as
T8971 7648-7651 DT denotes the
T8972 7652-7655 NNP denotes Fas
T8973 7656-7659 NNP denotes Fas
T8974 7660-7666 VBD denotes ligand
T8975 7667-7674 NN denotes pathway
T8976 7674-7675 . denotes .
T20185 1156-1159 NNP denotes Key
T20186 1160-1164 NN denotes role
T20187 1165-1168 IN denotes for
T20188 1169-1174 NNP denotes Runx3
T20189 1175-1177 IN denotes in
T20190 1178-1186 NN denotes effector
T20191 1187-1190 NNP denotes CTL
T20192 1191-1206 NN denotes differentiation
T20193 1206-1207 . denotes .
T20194 1208-1209 -LRB- denotes (
T20195 1209-1210 NNP denotes A
T20196 1210-1211 -RRB- denotes )
T20197 1212-1219 NNP denotes Western
T20198 1220-1228 NN denotes analysis
T20199 1229-1231 IN denotes of
T20200 1232-1237 NNP denotes Runx3
T20201 1237-1238 , denotes ,
T20202 1239-1244 NNP denotes Eomes
T20203 1244-1245 , denotes ,
T20204 1246-1251 NNP denotes T-bet
T20205 1251-1252 , denotes ,
T20206 1253-1256 CC denotes and
T20207 1257-1265 NN denotes perforin
T20208 1266-1276 NN denotes expression
T20209 1277-1279 IN denotes in
T20210 1280-1285 NNP denotes Runx3
T20211 1285-1286 NNP denotes +
T20212 1286-1287 VBD denotes /
T20213 1287-1288 CD denotes +
T20214 1289-1295 CC denotes versus
T20215 1296-1301 NNP denotes Runx3
T20216 1301-1302 FW denotes −
T20217 1302-1303 FW denotes /
T20218 1303-1304 FW denotes −
T20219 1305-1308 FW denotes CD8
T20220 1308-1309 FW denotes +
T20221 1310-1312 FW denotes SP
T20222 1313-1314 FW denotes T
T20223 1315-1320 NNS denotes cells
T20224 1321-1335 VBN denotes differentiated
T20225 1336-1339 IN denotes for
T20226 1340-1341 CD denotes 6
T20227 1342-1344 NN denotes d.
T20228 1345-1352 NN denotes β-Actin
T20229 1353-1356 VBD denotes was
T20230 1357-1361 VBN denotes used
T20231 1362-1364 IN denotes as
T20232 1365-1366 DT denotes a
T20233 1367-1374 VBG denotes loading
T20234 1375-1382 NN denotes control
T20235 1382-1383 . denotes .
T20236 1384-1385 -LRB- denotes (
T20237 1385-1386 NNP denotes B
T20238 1386-1387 -RRB- denotes )
T20239 1388-1396 NNP denotes Northern
T20240 1397-1401 NN denotes blot
T20241 1402-1410 NN denotes analysis
T20242 1411-1413 IN denotes of
T20243 1414-1418 NNP denotes Prf1
T20244 1419-1423 NNP denotes mRNA
T20245 1424-1434 NN denotes expression
T20246 1435-1437 IN denotes in
T20247 1438-1443 NNP denotes Runx3
T20248 1443-1444 NNP denotes +
T20249 1444-1445 VBD denotes /
T20250 1445-1446 CD denotes +
T20251 1447-1453 CC denotes versus
T20252 1454-1459 NNP denotes Runx3
T20253 1459-1460 FW denotes −
T20254 1460-1461 FW denotes /
T20255 1461-1462 FW denotes −
T20256 1463-1466 FW denotes CD8
T20257 1466-1467 FW denotes +
T20258 1468-1469 FW denotes T
T20259 1470-1475 NNS denotes cells
T20260 1476-1490 VBN denotes differentiated
T20261 1491-1494 IN denotes for
T20262 1495-1496 CD denotes 6
T20263 1497-1499 NN denotes d.
T20264 1500-1501 NN denotes β
T20265 1502-1507 NNP denotes Actin
T20266 1508-1511 VBD denotes was
T20267 1512-1516 VBN denotes used
T20268 1517-1519 IN denotes as
T20269 1520-1521 DT denotes a
T20270 1522-1529 VBG denotes loading
T20271 1530-1537 NN denotes control
T20272 1537-1538 . denotes .
T20273 1539-1540 -LRB- denotes (
T20274 1540-1541 $ denotes C
T20275 1541-1542 -RRB- denotes )
T20276 1543-1553 NN denotes Expression
T20277 1554-1556 IN denotes of
T20278 1557-1565 NN denotes granzyme
T20279 1566-1567 NNP denotes B
T20280 1567-1568 , denotes ,
T20281 1569-1574 NNP denotes IFN-γ
T20282 1574-1575 , denotes ,
T20283 1576-1579 NNP denotes TNF
T20284 1579-1580 , denotes ,
T20285 1581-1584 CC denotes and
T20286 1585-1589 NN denotes IL-2
T20287 1590-1592 IN denotes by
T20288 1593-1600 VBG denotes resting
T20289 1601-1603 CC denotes or
T20290 1604-1616 VBN denotes restimulated
T20291 1617-1618 -LRB- denotes (
T20292 1618-1619 CD denotes 6
T20293 1620-1621 NN denotes h
T20294 1621-1622 -RRB- denotes )
T20295 1623-1628 JJ denotes Runx3
T20296 1628-1629 NN denotes +
T20297 1629-1630 NN denotes /
T20298 1630-1631 NN denotes +
T20299 1632-1638 IN denotes versus
T20300 1639-1644 NNP denotes Runx3
T20301 1644-1645 NNP denotes −
T20302 1645-1646 VBD denotes /
T20303 1646-1647 CD denotes −
T20304 1648-1651 CD denotes CD8
T20305 1651-1652 NN denotes +
T20306 1653-1655 NNP denotes SP
T20307 1656-1657 NNP denotes T
T20308 1658-1663 NNS denotes cells
T20309 1664-1678 VBD denotes differentiated
T20310 1679-1682 IN denotes for
T20311 1683-1684 CD denotes 6
T20312 1685-1686 LS denotes d
T20313 1686-1687 . denotes .
T20314 1688-1691 DT denotes The
T20315 1692-1700 JJ denotes vertical
T20316 1701-1705 JJ denotes gray
T20317 1706-1710 NN denotes line
T20318 1711-1720 VBZ denotes indicates
T20319 1721-1724 DT denotes the
T20320 1725-1733 NN denotes granzyme
T20321 1734-1735 NNP denotes B
T20322 1736-1739 NNP denotes MFI
T20323 1740-1743 IN denotes for
T20324 1744-1746 NNP denotes WT
T20325 1747-1750 NNP denotes GFP
T20326 1750-1751 NN denotes +
T20327 1752-1757 NNS denotes cells
T20328 1757-1758 . denotes .
T20329 1759-1766 NNS denotes Results
T20330 1767-1769 IN denotes in
T20331 1770-1771 DT denotes A
T20332 1772-1773 NNP denotes C
T20333 1774-1777 VBP denotes are
T20334 1778-1792 JJ denotes representative
T20335 1793-1795 IN denotes of
T20336 1796-1799 CD denotes two
T20337 1800-1811 JJ denotes independent
T20338 1812-1823 NNS denotes experiments
T20339 1823-1824 . denotes .
T20340 1825-1826 -LRB- denotes (
T20341 1826-1827 NNP denotes D
T20342 1827-1828 -RRB- denotes )
T20343 1829-1833 NNP denotes ChIP
T20344 1834-1842 NN denotes analysis
T20345 1843-1845 IN denotes of
T20346 1846-1853 JJ denotes binding
T20347 1854-1856 IN denotes of
T20348 1857-1867 JJ denotes endogenous
T20349 1868-1873 NNP denotes Runx3
T20350 1874-1877 CC denotes and
T20351 1878-1883 NNP denotes Eomes
T20352 1884-1886 TO denotes to
T20353 1887-1890 DT denotes the
T20354 1891-1895 JJ denotes Prf1
T20355 1896-1901 NN denotes locus
T20356 1901-1902 . denotes .
T20357 1903-1913 NNP denotes Enrichment
T20358 1914-1916 IN denotes of
T20393 2137-2138 NNP denotes T
T20394 2139-2143 NN denotes cell
T20395 2144-2160 NNS denotes differentiations
T20396 2160-2161 . denotes .
T20397 2162-2165 DT denotes The
T20398 2166-2176 NN denotes efficiency
T20399 2177-2179 IN denotes of
T20400 2180-2188 NN denotes recovery
T20401 2189-2191 IN denotes of
T20402 2192-2197 NN denotes input
T20403 2198-2201 IN denotes for
T20404 2202-2205 DT denotes the
T20405 2206-2207 NN denotes −
T20406 2207-2211 JJ denotes 1-kb
T20407 2212-2218 NN denotes region
T20408 2219-2221 IN denotes of
T20409 2222-2226 NNP denotes Prf1
T20410 2227-2230 VBD denotes was
T20411 2231-2235 CD denotes 0.97
T20412 2235-2236 NN denotes %
T20413 2237-2240 IN denotes for
T20414 2241-2244 DT denotes the
T20415 2245-2250 NNP denotes Runx3
T20416 2251-2255 NNP denotes ChIP
T20417 2256-2259 CC denotes and
T20418 2260-2263 CD denotes 0.5
T20419 2263-2264 NN denotes %
T20420 2265-2268 IN denotes for
T20421 2269-2272 DT denotes the
T20422 2273-2278 NNP denotes Eomes
T20423 2279-2283 NNP denotes ChIP
T20424 2283-2284 . denotes .
T20970 5324-5325 , denotes ,
T20971 5326-5334 NN denotes perforin
T20972 5334-5335 , denotes ,
T20973 5336-5344 NN denotes granzyme
T20974 5345-5346 NNP denotes B
T20975 5346-5347 , denotes ,
T20976 5348-5351 CC denotes and
T20977 5352-5357 NNP denotes IFN-γ
T20978 5358-5368 NN denotes expression
T20979 5369-5371 IN denotes in
T20980 5372-5380 NN denotes effector
T20981 5381-5385 NNS denotes CTLs
T20982 5385-5386 . denotes .
T20983 5387-5392 JJ denotes Runx3
T20984 5392-5393 NN denotes +
T20985 5393-5394 NN denotes /
T20986 5394-5395 NN denotes +
T20987 5396-5398 CC denotes or
T20988 5399-5404 JJ denotes Runx3
T20989 5404-5405 FW denotes −
T20990 5405-5406 FW denotes /
T20991 5406-5407 FW denotes −
T20992 5408-5411 FW denotes CD8
T20993 5411-5412 FW denotes +
T20994 5413-5414 FW denotes T
T20995 5415-5420 NNS denotes cells
T20996 5421-5425 VBD denotes were
T20997 5426-5435 VBN denotes activated
T20998 5436-5439 CC denotes and
T20999 5440-5450 VBN denotes transduced
T21000 5451-5455 IN denotes with
T21001 5456-5468 NNS denotes retroviruses
T21002 5469-5476 VBG denotes bearing
T21003 5477-5479 DT denotes an
T21004 5480-5485 JJ denotes empty
T21005 5486-5494 NNP denotes IRES-GFP
T21006 5495-5503 NN denotes cassette
T21007 5504-5505 -LRB- denotes (
T21008 5505-5508 NNP denotes GFP
T21009 5508-5509 -RRB- denotes )
T21010 5510-5512 CC denotes or
T21011 5513-5517 RB denotes also
T21012 5518-5526 VBG denotes encoding
T21013 5527-5537 NNP denotes Eomes-VP16
T21014 5538-5539 -LRB- denotes (
T21015 5539-5546 NNP denotes Eo-VP16
T21016 5546-5547 -RRB- denotes )
T21017 5548-5550 CC denotes or
T21018 5551-5560 JJ denotes Myc-Runx3
T21019 5561-5562 -LRB- denotes (
T21020 5562-5567 JJ denotes Runx3
T21021 5567-5568 -RRB- denotes )
T21022 5568-5569 . denotes .
T21023 5570-5573 DT denotes The
T21024 5574-5583 NN denotes frequency
T21025 5584-5586 IN denotes of
T21026 5587-5597 JJ denotes transduced
T21027 5598-5603 NNS denotes cells
T21028 5604-5606 IN denotes in
T21029 5607-5610 DT denotes the
T21030 5611-5619 NNS denotes cultures
T21031 5620-5623 VBD denotes was
T21032 5624-5634 JJ denotes equivalent
T21033 5635-5638 IN denotes for
T21034 5639-5642 DT denotes all
T21035 5643-5653 NNS denotes constructs
T21036 5654-5655 -LRB- denotes (
T21037 5655-5656 CD denotes ∼
T21038 5656-5658 CD denotes 75
T21039 5659-5661 CD denotes 90
T21040 5661-5662 NN denotes %
T21041 5663-5666 NNP denotes GFP
T21042 5666-5667 CD denotes +
T21043 5668-5673 NNS denotes cells
T21044 5673-5674 : denotes ;
T21045 5675-5678 RB denotes not
T21046 5679-5687 VBN denotes depicted
T21047 5687-5688 -RRB- denotes )
T21048 5688-5689 . denotes .
T21049 5690-5691 -LRB- denotes (
T21050 5691-5692 NNP denotes A
T21051 5692-5693 -RRB- denotes )
T21052 5694-5701 NNP denotes Protein
T21053 5702-5712 NN denotes expression
T21054 5713-5715 IN denotes in
T21055 5716-5726 JJ denotes whole-cell
T21056 5727-5735 NNS denotes extracts
T21057 5736-5737 -LRB- denotes (
T21058 5737-5740 NN denotes day
T21059 5741-5742 CD denotes 6
T21060 5742-5743 -RRB- denotes )
T21061 5744-5747 VBD denotes was
T21062 5748-5756 VBN denotes analyzed
T21063 5757-5759 IN denotes by
T21064 5760-5774 VBG denotes immunoblotting
T21065 5774-5775 . denotes .
T21066 5776-5790 NNP denotes Overexpression
T21067 5791-5793 IN denotes of
T21068 5794-5804 NNP denotes Eomes-VP16
T21069 5805-5808 MD denotes can
T21070 5808-5811 RB denotes not
T21071 5812-5814 VB denotes be
T21072 5815-5823 VBN denotes detected
T21073 5824-5828 IN denotes with
T21074 5829-5832 DT denotes the
T21075 5833-5838 NNP denotes Eomes
T21076 5839-5847 NN denotes antibody
T21077 5847-5848 , denotes ,
T21078 5849-5851 IN denotes as
T21079 5852-5855 DT denotes the
T21080 5856-5866 JJ denotes C-terminal
T21081 5867-5874 NN denotes epitope
T21082 5875-5877 VBZ denotes is
T21083 5878-5884 IN denotes within
T21084 5885-5888 DT denotes the
T21085 5889-5895 NN denotes region
T21086 5896-5900 WDT denotes that
T21087 5901-5904 VBZ denotes has
T21088 5905-5909 VBN denotes been
T21089 5910-5918 VBN denotes replaced
T21090 5919-5923 IN denotes with
T21091 5924-5927 DT denotes the
T21092 5928-5932 NNP denotes VP16
T21093 5933-5948 NN denotes transactivation
T21094 5949-5955 NN denotes domain
T21095 5955-5956 . denotes .
T21096 5957-5958 -LRB- denotes (
T21097 5958-5959 NNP denotes B
T21098 5959-5960 -RRB- denotes )
T21099 5961-5971 NN denotes Expression
T21100 5972-5974 IN denotes of
T21101 5975-5983 NN denotes granzyme
T21102 5984-5985 NNP denotes B
T21103 5986-5989 CC denotes and
T21104 5990-5995 NNP denotes IFN-γ
T21105 5996-6001 IN denotes after
T21106 6002-6009 NN denotes culture
T21107 6010-6013 IN denotes for
T21108 6014-6015 CD denotes 6
T21109 6016-6017 LS denotes d
T21110 6018-6021 CC denotes and
T21111 6022-6035 NN denotes restimulation
T21112 6036-6039 IN denotes for
T21113 6040-6041 CD denotes 4
T21114 6042-6043 NN denotes h
T21115 6044-6048 IN denotes with
T21116 6049-6052 NNP denotes PMA
T21117 6053-6056 CC denotes and
T21118 6057-6066 NN denotes ionomycin
T21119 6067-6070 VBD denotes was
T21120 6071-6081 VBN denotes determined
T21121 6082-6084 IN denotes by
T21122 6085-6098 JJ denotes intracellular
T21123 6099-6107 NN denotes staining
T21124 6107-6108 . denotes .
T21125 6109-6112 DT denotes The
T21126 6113-6123 NN denotes percentage
T21127 6124-6126 IN denotes of
T21128 6127-6137 RB denotes positively
T21129 6138-6145 VBN denotes stained
T21130 6146-6151 NNS denotes cells
T21131 6152-6154 VBZ denotes is
T21132 6155-6160 VBN denotes shown
T21133 6161-6166 IN denotes above
T21134 6167-6170 DT denotes the
T21135 6171-6175 NN denotes gate
T21136 6175-6176 : denotes ;
T21137 6177-6180 DT denotes the
T21138 6181-6185 JJ denotes mean
T21139 6186-6198 NN denotes fluorescence
T21140 6199-6208 NN denotes intensity
T21141 6209-6210 -LRB- denotes (
T21142 6210-6213 NNP denotes MFI
T21143 6213-6214 -RRB- denotes )
T21144 6215-6217 IN denotes of
T21145 6218-6226 NN denotes granzyme
T21146 6227-6228 NNP denotes B
T21147 6229-6237 VBG denotes staining
T21148 6238-6241 IN denotes for
T21149 6242-6245 DT denotes the
T21150 6246-6251 JJ denotes total
T21151 6252-6262 NN denotes population
T21152 6263-6265 VBZ denotes is
T21153 6266-6271 VBN denotes shown
T21154 6272-6277 IN denotes below
T21155 6278-6281 DT denotes the
T21156 6282-6286 NN denotes gate
T21157 6286-6287 . denotes .
T21158 6288-6291 DT denotes The
T21159 6292-6300 JJ denotes vertical
T21160 6301-6305 JJ denotes gray
T21161 6306-6311 NNS denotes lines
T21162 6312-6320 VBP denotes indicate
T21163 6321-6324 DT denotes the
T21164 6325-6328 NNP denotes MFI
T21165 6329-6332 IN denotes for
T21166 6333-6335 NNP denotes WT
T21167 6336-6339 NNP denotes GFP
T21168 6339-6340 NN denotes +
T21169 6341-6346 NNS denotes cells
T21170 6346-6347 . denotes .
T21171 6348-6355 NNS denotes Results
T21172 6356-6359 VBP denotes are
T21173 6360-6374 NN denotes representative
T21174 6375-6377 IN denotes of
T21175 6378-6380 IN denotes at
T21176 6381-6386 JJS denotes least
T21177 6387-6390 CD denotes two
T21178 6391-6402 JJ denotes independent
T21179 6403-6414 NNS denotes experiments
T21180 6414-6415 . denotes .
T21181 6416-6417 -LRB- denotes (
T21182 6417-6418 $ denotes C
T21183 6418-6419 -RRB- denotes )
T21184 6420-6429 JJ denotes Schematic
T21185 6430-6437 NN denotes diagram
T21186 6438-6440 IN denotes of
T21187 6441-6444 DT denotes the
T21188 6445-6460 JJ denotes transcriptional
T21189 6461-6468 NN denotes network
T21190 6469-6478 VBG denotes involving
T21191 6479-6484 NNP denotes Runx3
T21192 6485-6488 CC denotes and
T21193 6489-6494 NNP denotes T-box
T21194 6495-6502 NNS denotes factors
T21195 6502-6503 . denotes .
T21196 6504-6509 NN denotes T-bet
T21197 6510-6512 VBZ denotes is
T21198 6513-6520 VBN denotes induced
T21199 6521-6523 IN denotes by
T21200 6524-6527 NNP denotes TCR
T21201 6528-6535 NNS denotes signals
T21202 6536-6539 CC denotes and
T21203 6540-6542 VBZ denotes is
T21204 6543-6552 JJ denotes essential
T21205 6553-6556 IN denotes for
T21206 6557-6562 JJ denotes early
T21207 6563-6568 JJ denotes IFN-γ
T21208 6569-6579 NN denotes expression
T21209 6579-6580 . denotes .
T21210 6581-6586 NN denotes Runx3
T21211 6587-6589 VBZ denotes is
T21212 6590-6597 JJ denotes present
T21213 6598-6600 IN denotes in
T21214 6601-6606 JJ denotes naive
T21215 6607-6610 NNP denotes CD8
T21216 6610-6611 CD denotes +
T21217 6612-6613 NNP denotes T
T21218 6614-6619 NNS denotes cells
T21219 6620-6623 CC denotes and
T21220 6624-6633 VBZ denotes represses
T21221 6634-6639 NNP denotes Runx1
T21222 6640-6643 CC denotes and
T21223 6644-6651 VBZ denotes induces
T21224 6652-6657 NNP denotes Eomes
T21225 6657-6658 , denotes ,
T21226 6659-6667 NN denotes perforin
T21227 6667-6668 , denotes ,
T21228 6669-6677 NN denotes granzyme
T21229 6678-6679 NNP denotes B
T21230 6679-6680 , denotes ,
T21231 6681-6684 CC denotes and
T21232 6685-6690 NNP denotes IFN-γ
T21233 6691-6701 NN denotes expression
T21234 6701-6702 . denotes .
T21235 6703-6708 NNS denotes Eomes
T21236 6709-6712 MD denotes may
T21237 6713-6724 VB denotes participate
T21238 6725-6727 IN denotes in
T21239 6728-6738 VBG denotes sustaining
T21240 6739-6743 JJ denotes late
T21241 6744-6749 JJ denotes IFN-γ
T21242 6750-6760 NN denotes expression
T21243 6760-6761 , denotes ,
T21244 6762-6769 IN denotes whereas
T21245 6770-6775 NNP denotes Runx3
T21246 6776-6779 CC denotes and
T21247 6780-6785 NNP denotes Eomes
T21248 6786-6787 -LRB- denotes (
T21249 6787-6790 CC denotes but
T21250 6791-6794 RB denotes not
T21251 6795-6800 NNP denotes T-bet
T21252 6800-6801 -RRB- denotes )
T21253 6802-6805 MD denotes may
T21254 6806-6815 VB denotes cooperate
T21255 6816-6818 TO denotes to
T21256 6819-6827 VB denotes activate
T21257 6828-6836 JJ denotes perforin
T21258 6837-6847 NN denotes expression
T21259 6847-6848 . denotes .
T21260 6849-6852 DT denotes The
T21261 6853-6859 JJ denotes dotted
T20359 1917-1920 DT denotes the
T20360 1921-1930 VBN denotes indicated
T20361 1931-1938 JJ denotes genomic
T20362 1939-1946 NNS denotes regions
T20363 1947-1950 VBD denotes was
T20364 1951-1960 VBN denotes evaluated
T20365 1961-1963 IN denotes by
T20366 1964-1973 JJ denotes real-time
T20367 1974-1977 NNP denotes PCR
T20368 1978-1980 IN denotes of
T20369 1981-1984 NNP denotes DNA
T20370 1985-1989 IN denotes from
T20371 1990-2008 JJ denotes immunoprecipitated
T20372 2009-2012 CC denotes and
T20373 2013-2018 NN denotes input
T20374 2019-2028 NN denotes chromatin
T20375 2028-2029 . denotes .
T20376 2030-2033 DT denotes The
T20377 2034-2038 NNS denotes data
T20378 2039-2042 VBP denotes are
T20379 2043-2046 DT denotes the
T20380 2047-2052 NNS denotes means
T20381 2053-2055 IN denotes of
T20382 2056-2065 VBP denotes duplicate
T20383 2066-2078 NNS denotes measurements
T20384 2079-2083 IN denotes from
T20385 2084-2087 CD denotes two
T20386 2088-2097 NN denotes chromatin
T20387 2098-2110 NNS denotes preparations
T20388 2111-2115 IN denotes from
T20389 2116-2119 CD denotes two
T20390 2120-2131 JJ denotes independent
T20391 2132-2135 NNP denotes CD8
T20392 2135-2136 CD denotes +
T20967 5304-5309 JJ denotes Runx3
T20968 5310-5318 NNS denotes controls
T20969 5319-5324 NNP denotes Eomes
T21262 6860-6864 NN denotes line
T21263 6865-6874 VBZ denotes indicates
T21264 6875-6878 DT denotes the
T21265 6879-6886 JJ denotes partial
T21266 6887-6893 NN denotes effect
T21267 6894-6896 IN denotes of
T21268 6897-6902 NN denotes T-bet
T21269 6903-6913 NN denotes deficiency
T21270 6914-6916 IN denotes on
T21271 6917-6921 NNP denotes Gzmb
T21272 6922-6926 NNP denotes mRNA
T21273 6927-6930 CC denotes but
T21274 6931-6934 RB denotes not
T21275 6935-6943 VB denotes granzyme
T21276 6944-6945 NNP denotes B
T21277 6946-6953 NN denotes protein
T21278 6954-6964 NN denotes expression
T21279 6964-6965 . denotes .
R6174 T7997 T7998 amod Runx3,controls
R6175 T7998 T8044 nsubj controls,examined
R6176 T7999 T8000 amod multiple,aspects
R6177 T8000 T7998 dobj aspects,controls
R6178 T8001 T8000 prep of,aspects
R6179 T8002 T8005 det the,program
R6180 T8003 T8005 compound CTL,program
R6181 T8004 T8005 compound differentiation,program
R6182 T8005 T8001 pobj program,of
R6183 T8006 T7998 punct ",",controls
R6184 T8007 T7998 prep in,controls
R6185 T8008 T8007 pobj part,in
R6186 T8009 T7998 prep through,controls
R6187 T8010 T8009 pobj induction,through
R6188 T8011 T8010 prep of,induction
R6189 T8012 T8011 pobj Eomes,of
R6190 T8013 T8017 mark Because,expressed
R6191 T8014 T8017 nsubjpass Runx3,expressed
R6192 T8015 T8017 auxpass is,expressed
R6193 T8016 T8017 advmod highly,expressed
R6194 T8017 T7998 advcl expressed,controls
R6195 T8018 T8017 prep in,expressed
R6196 T8019 T8023 amod peripheral,cells
R6197 T8020 T8023 nmod CD8,cells
R6198 T8021 T8023 nummod +,cells
R6199 T8022 T8023 compound T,cells
R6200 T8023 T8018 pobj cells,in
R6201 T8024 T8017 punct ",",expressed
R6202 T8025 T8017 cc and,expressed
R6203 T8026 T8044 prep because,examined
R6204 T8027 T8026 pcomp of,because
R6205 T8028 T8030 det the,cooperation
R6206 T8029 T8030 amod T-bet-Runx3,cooperation
R6207 T8030 T8026 pobj cooperation,because
R6208 T8031 T8032 nsubj we,observed
R6209 T8032 T8030 relcl observed,cooperation
R6210 T8033 T8032 advmod earlier,observed
R6211 T8034 T8033 prep in,earlier
R6212 T8035 T8038 nummod CD4,cells
R6213 T8036 T8038 nummod +,cells
R6214 T8037 T8038 compound T,cells
R6215 T8038 T8034 pobj cells,in
R6216 T8039 T8030 punct (,cooperation
R6217 T8040 T8030 appos 15,cooperation
R6218 T8041 T8030 punct ),cooperation
R6219 T8042 T8044 punct ",",examined
R6220 T8043 T8044 nsubj we,examined
R6221 T8044 T8044 ROOT examined,examined
R6222 T8045 T8046 det the,role
R6223 T8046 T8044 dobj role,examined
R6224 T8047 T8046 prep of,role
R6225 T8048 T8047 pobj Runx3,of
R6226 T8049 T8046 prep in,role
R6227 T8050 T8051 compound effector,CTL
R6228 T8051 T8052 compound CTL,differentiation
R6229 T8052 T8049 pobj differentiation,in
R6230 T8053 T8044 punct .,examined
R6231 T8054 T8055 nsubj We,isolated
R6232 T8055 T8055 ROOT isolated,isolated
R6233 T8056 T8059 compound CD8,cells
R6234 T8057 T8059 compound +,cells
R6235 T8058 T8059 compound T,cells
R6236 T8059 T8055 dobj cells,isolated
R6237 T8060 T8059 prep from,cells
R6238 T8061 T8064 amod Runx3,−
R6239 T8062 T8064 compound −,−
R6240 T8063 T8064 compound /,−
R6241 T8064 T8060 pobj −,from
R6242 T8065 T8064 punct (,−
R6243 T8066 T8064 parataxis KO,−
R6244 T8067 T8064 punct ),−
R6245 T8068 T8060 pobj mice,from
R6246 T8069 T8068 prep of,mice
R6247 T8070 T8073 det the,background
R6248 T8071 T8073 amod outbred,background
R6249 T8072 T8073 compound ICR,background
R6250 T8073 T8069 pobj background,of
R6251 T8074 T8073 cc and,background
R6252 T8075 T8077 poss their,Runx3
R6253 T8076 T8077 compound WT,Runx3
R6254 T8077 T8078 nsubj Runx3,+
R6255 T8078 T8055 conj +,isolated
R6256 T8079 T8081 nummod /,littermates
R6257 T8080 T8081 compound +,littermates
R6258 T8081 T8078 dobj littermates,+
R6259 T8082 T8078 prep by,+
R6260 T8083 T8084 amod positive,selection
R6261 T8084 T8082 pobj selection,by
R6262 T8085 T8084 prep with,selection
R6263 T8086 T8088 amod anti-CD8,beads
R6264 T8087 T8088 amod magnetic,beads
R6265 T8088 T8085 pobj beads,with
R6266 T8089 T8088 punct (,beads
R6267 T8090 T8088 appos Figs,beads
R6268 T8091 T8078 punct .,+
R6269 T8092 T8092 ROOT S1,S1
R6270 T8093 T8092 cc and,S1
R6271 T8094 T8092 conj S2,S1
R6272 T8095 T8092 punct ",",S1
R6273 T8096 T8092 amod available,S1
R6274 T8097 T8096 prep at,available
R6275 T8098 T8097 pobj http://www.jem.org/cgi/content/full/jem.20081242/DC1,at
R6276 T8099 T8092 punct ),S1
R6277 T8100 T8092 punct .,S1
R6278 T8101 T8113 advmod Strikingly,impaired
R6279 T8102 T8113 punct ",",impaired
R6280 T8103 T8110 amod Runx3,cells
R6281 T8104 T8110 nmod −,cells
R6282 T8105 T8110 nmod /,cells
R6283 T8106 T8110 nmod −,cells
R6284 T8107 T8110 nmod CD8,cells
R6285 T8108 T8110 nmod +,cells
R6286 T8109 T8110 compound T,cells
R6287 T8110 T8113 nsubjpass cells,impaired
R6288 T8111 T8113 auxpass were,impaired
R6289 T8112 T8113 advmod strongly,impaired
R6290 T8113 T8113 ROOT impaired,impaired
R6291 T8114 T8113 prep in,impaired
R6292 T8115 T8116 poss their,ability
R6293 T8116 T8114 pobj ability,in
R6294 T8117 T8118 aux to,differentiate
R6295 T8118 T8116 acl differentiate,ability
R6296 T8119 T8118 prep into,differentiate
R6297 T8120 T8121 compound effector,CTLs
R6298 T8121 T8119 pobj CTLs,into
R6299 T8122 T8113 punct ",",impaired
R6300 T8123 T8124 mark as,judged
R6301 T8124 T8113 advcl judged,impaired
R6302 T8125 T8124 agent by,judged
R6303 T8126 T8125 pobj expression,by
R6304 T8127 T8126 prep of,expression
R6305 T8128 T8127 pobj perforin,of
R6306 T8129 T8113 punct ",",impaired
R6307 T8130 T8131 compound granzyme,B
R6308 T8131 T8113 dobj B,impaired
R6309 T8132 T8113 punct ",",impaired
R6310 T8133 T8113 cc and,impaired
R6311 T8134 T8113 conj IFN-γ,impaired
R6312 T8135 T8136 punct (,Fig.
R6313 T8136 T8134 appos Fig.,IFN-γ
R6314 T8137 T8136 nummod 3,Fig.
R6315 T8138 T8136 punct ),Fig.
R6316 T8139 T8113 punct .,impaired
R6317 T8140 T8151 prep Compared,were
R6318 T8141 T8140 prep with,Compared
R6319 T8142 T8144 compound WT,cells
R6320 T8143 T8144 compound T,cells
R6321 T8144 T8141 pobj cells,with
R6322 T8145 T8151 punct ",",were
R6323 T8146 T8147 compound perforin,mRNA
R6324 T8147 T8151 nsubj mRNA,were
R6325 T8148 T8147 cc and,mRNA
R6326 T8149 T8150 compound protein,expression
R6327 T8150 T8147 conj expression,mRNA
R6328 T8151 T8151 ROOT were,were
R6329 T8152 T8153 advmod essentially,undetectable
R6330 T8153 T8151 acomp undetectable,were
R6331 T8154 T8153 prep in,undetectable
R6332 T8155 T8156 compound Runx3,−
R6333 T8156 T8154 pobj −,in
R6334 T8157 T8151 conj /,were
R6335 T8158 T8160 nummod −,cells
R6336 T8159 T8160 compound T,cells
R6337 T8160 T8157 dobj cells,/
R6338 T8161 T8157 prep at,/
R6339 T8162 T8161 pobj day,at
R6340 T8163 T8162 nummod 6,day
R6341 T8164 T8162 prep of,day
R6342 T8165 T8164 pobj culture,of
R6343 T8166 T8170 punct (,A
R6344 T8167 T8170 intj Fig.,A
R6345 T8168 T8167 nummod 3,Fig.
R6346 T8169 T8167 punct ",",Fig.
R6347 T8170 T8157 parataxis A,/
R6348 T8171 T8170 cc and,A
R6349 T8172 T8170 conj B,A
R6350 T8173 T8172 punct ),B
R6351 T8174 T8151 punct .,were
R6352 T8175 T8180 amod Runx3,cells
R6353 T8176 T8180 nmod −,cells
R6354 T8177 T8180 nmod /,cells
R6355 T8178 T8180 nmod −,cells
R6356 T8179 T8180 compound T,cells
R6357 T8180 T8182 nsubj cells,had
R6358 T8181 T8182 advmod also,had
R6359 T8182 T8194 ccomp had,unimpaired
R6360 T8183 T8186 det no,expression
R6361 T8184 T8186 amod detectable,expression
R6362 T8185 T8186 compound Eomes,expression
R6363 T8186 T8182 dobj expression,had
R6364 T8187 T8194 punct ;,unimpaired
R6365 T8188 T8194 prep in,unimpaired
R6366 T8189 T8188 pobj contrast,in
R6367 T8190 T8194 punct ",",unimpaired
R6368 T8191 T8192 compound T-bet,expression
R6369 T8192 T8194 nsubjpass expression,unimpaired
R6370 T8193 T8194 auxpass was,unimpaired
R6371 T8194 T8194 ROOT unimpaired,unimpaired
R6372 T8195 T8194 punct (,unimpaired
R6373 T8196 T8194 parataxis Fig.,unimpaired
R6374 T8197 T8198 nummod 3,A
R6375 T8198 T8196 pobj A,Fig.
R6376 T8199 T8194 punct ),unimpaired
R6377 T8200 T8194 punct .,unimpaired
R6378 T8201 T8205 advmod Furthermore,required
R6379 T8202 T8205 punct ",",required
R6380 T8203 T8205 nsubjpass Runx3,required
R6381 T8204 T8205 auxpass was,required
R6382 T8205 T8205 ROOT required,required
R6383 T8206 T8205 prep for,required
R6384 T8207 T8208 amod maximal,production
R6385 T8208 T8206 pobj production,for
R6386 T8209 T8208 prep of,production
R6387 T8210 T8209 pobj IFN-γ,of
R6388 T8211 T8205 punct ",",required
R6389 T8212 T8205 cc but,required
R6390 T8213 T8214 neg not,TNF
R6391 T8214 T8214 ROOT TNF,TNF
R6392 T8215 T8214 cc or,TNF
R6393 T8216 T8214 conj IL-2,TNF
R6394 T8217 T8214 punct ",",TNF
R6395 T8218 T8223 agent by,restimulated
R6396 T8219 T8222 nummod CD8,cells
R6397 T8220 T8222 nummod +,cells
R6398 T8221 T8222 compound T,cells
R6399 T8222 T8218 pobj cells,by
R6400 T8223 T8205 conj restimulated,required
R6401 T8224 T8223 prep at,restimulated
R6402 T8225 T8224 pobj day,at
R6403 T8226 T8225 nummod 6,day
R6404 T8227 T8228 punct (,Fig.
R6405 T8228 T8223 parataxis Fig.,restimulated
R6406 T8229 T8228 nummod 3,Fig.
R6407 T8230 T8228 appos C,Fig.
R6408 T8231 T8228 punct ),Fig.
R6409 T8232 T8205 punct .,required
R6410 T8233 T8235 nsubj We,reported
R6411 T8234 T8235 advmod previously,reported
R6412 T8235 T8235 ROOT reported,reported
R6413 T8236 T8241 mark that,regulated
R6414 T8237 T8239 amod Th1,differentiation
R6415 T8238 T8239 compound cell,differentiation
R6416 T8239 T8241 nsubjpass differentiation,regulated
R6417 T8240 T8241 auxpass was,regulated
R6418 T8241 T8235 ccomp regulated,reported
R6419 T8242 T8241 prep through,regulated
R6420 T8243 T8245 det a,loop
R6421 T8244 T8245 amod feed-forward,loop
R6422 T8245 T8242 pobj loop,through
R6423 T8246 T8249 prep in,is
R6424 T8247 T8246 pobj which,in
R6425 T8248 T8249 nsubj T-bet,is
R6426 T8249 T8245 relcl is,loop
R6427 T8250 T8249 acomp up-regulated,is
R6428 T8251 T8249 advmod early,is
R6429 T8252 T8249 cc and,is
R6430 T8253 T8249 conj induces,is
R6431 T8254 T8253 dobj Runx3,induces
R6432 T8255 T8253 punct ",",induces
R6433 T8256 T8261 prep after,cooperate
R6434 T8257 T8256 pobj which,after
R6435 T8258 T8261 nsubj T-bet,cooperate
R6436 T8259 T8258 cc and,T-bet
R6437 T8260 T8258 conj Runx3,T-bet
R6438 T8261 T8241 advcl cooperate,regulated
R6439 T8262 T8263 aux to,induce
R6440 T8263 T8261 xcomp induce,cooperate
R6441 T8264 T8263 dobj IFN-γ,induce
R6442 T8265 T8264 cc and,IFN-γ
R6443 T8266 T8267 compound silence,IL-4
R6444 T8267 T8264 conj IL-4,IFN-γ
R6445 T8268 T8263 punct ",",induce
R6446 T8269 T8270 advmod thus,promoting
R6447 T8270 T8261 advcl promoting,cooperate
R6448 T8271 T8272 amod stable,differentiation
R6449 T8272 T8270 dobj differentiation,promoting
R6450 T8273 T8272 prep toward,differentiation
R6451 T8274 T8276 det the,lineage
R6452 T8275 T8276 amod Th1,lineage
R6453 T8276 T8273 pobj lineage,toward
R6454 T8277 T8276 punct (,lineage
R6455 T8278 T8280 quantmod 15,22
R6456 T8279 T8280 punct ",",22
R6457 T8280 T8276 appos 22,lineage
R6458 T8281 T8276 punct ),lineage
R6459 T8282 T8235 punct .,reported
R6460 T8283 T8288 mark Because,appeared
R6461 T8284 T8285 punct (,a
R6462 T8285 T8288 meta a,appeared
R6463 T8286 T8285 punct ),a
R6464 T8287 T8288 nsubj Runx3,appeared
R6465 T8288 T8288 ROOT appeared,appeared
R6466 T8289 T8288 oprd necessary,appeared
R6467 T8290 T8288 prep for,appeared
R6468 T8291 T8292 compound Eomes,induction
R6469 T8292 T8290 pobj induction,for
R6470 T8293 T8294 punct (,Fig.
R6471 T8294 T8296 nmod Fig.,A
R6472 T8295 T8296 nummod 3,A
R6473 T8296 T8292 appos A,induction
R6474 T8297 T8296 punct ),A
R6475 T8298 T8292 punct ",",induction
R6476 T8299 T8300 punct (,b
R6477 T8300 T8292 appos b,induction
R6478 T8301 T8300 punct ),b
R6479 T8302 T8303 det the,kinetics
R6480 T8303 T8307 nsubj kinetics,paralleled
R6481 T8304 T8303 prep of,kinetics
R6482 T8305 T8306 compound Eomes,expression
R6483 T8306 T8304 pobj expression,of
R6484 T8307 T8288 conj paralleled,appeared
R6485 T8308 T8307 dobj those,paralleled
R6486 T8309 T8308 prep of,those
R6487 T8310 T8311 compound perforin,expression
R6488 T8311 T8309 pobj expression,of
R6489 T8312 T8311 punct (,expression
R6490 T8313 T8311 appos Fig.,expression
R6491 T8314 T8313 pobj 2,Fig.
R6492 T8315 T8311 punct ),expression
R6493 T8316 T8307 punct ",",paralleled
R6494 T8317 T8307 cc and,paralleled
R6495 T8318 T8319 punct (,c
R6496 T8319 T8321 meta c,overexpression
R6497 T8320 T8319 punct ),c
R6498 T8321 T8332 npadvmod overexpression,led
R6499 T8322 T8321 prep of,overexpression
R6500 T8323 T8322 pobj Eo-VP16,of
R6501 T8324 T8321 prep in,overexpression
R6502 T8325 T8326 det either,WT
R6503 T8326 T8324 pobj WT,in
R6504 T8327 T8326 cc or,WT
R6505 T8328 T8326 conj T-bet,WT
R6506 T8329 T8331 amod deficient,cells
R6507 T8330 T8331 compound T,cells
R6508 T8331 T8332 nsubj cells,led
R6509 T8332 T8307 conj led,paralleled
R6510 T8333 T8332 prep to,led
R6511 T8334 T8335 det an,increase
R6512 T8335 T8333 pobj increase,to
R6513 T8336 T8335 prep in,increase
R6514 T8337 T8338 preconj both,perforin
R6515 T8338 T8336 pobj perforin,in
R6516 T8339 T8338 cc and,perforin
R6517 T8340 T8341 amod IFN-γ,expression
R6518 T8341 T8338 conj expression,perforin
R6519 T8342 T8352 punct (,asked
R6520 T8343 T8352 nsubj Fig.,asked
R6521 T8344 T8343 nummod 2,Fig.
R6522 T8345 T8352 punct ",",asked
R6523 T8346 T8352 advcl B,asked
R6524 T8347 T8346 cc and,B
R6525 T8348 T8346 conj D,B
R6526 T8349 T8346 punct ),B
R6527 T8350 T8352 punct ",",asked
R6528 T8351 T8352 nsubj we,asked
R6529 T8352 T8352 ROOT asked,asked
R6530 T8353 T8356 mark whether,was
R6531 T8354 T8355 compound CTL,differentiation
R6532 T8355 T8356 nsubj differentiation,was
R6533 T8356 T8359 auxpass was,regulated
R6534 T8357 T8359 advmod also,regulated
R6535 T8358 T8359 advmod potentially,regulated
R6536 T8359 T8352 ccomp regulated,asked
R6537 T8360 T8359 agent by,regulated
R6538 T8361 T8363 det a,loop
R6539 T8362 T8363 amod feed-forward,loop
R6540 T8363 T8360 pobj loop,by
R6541 T8364 T8363 acl involving,loop
R6542 T8365 T8368 det these,classes
R6543 T8366 T8368 amod same,classes
R6544 T8367 T8368 nummod two,classes
R6545 T8368 T8364 dobj classes,involving
R6546 T8369 T8368 prep of,classes
R6547 T8370 T8369 pobj Runx,of
R6548 T8371 T8370 cc and,Runx
R6549 T8372 T8370 conj T-box,Runx
R6550 T8373 T8374 compound transcription,factors
R6551 T8374 T8368 conj factors,classes
R6552 T8375 T8352 punct .,asked
R6553 T8376 T8379 advmod Specifically,asked
R6554 T8377 T8379 punct ",",asked
R6555 T8378 T8379 nsubj we,asked
R6556 T8379 T8379 ROOT asked,asked
R6557 T8380 T8391 mark whether,cooperated
R6558 T8381 T8391 nsubj Runx3,cooperated
R6559 T8382 T8381 punct ",",Runx3
R6560 T8383 T8384 nsubj which,was
R6561 T8384 T8381 relcl was,Runx3
R6562 T8385 T8384 acomp necessary,was
R6563 T8386 T8385 prep for,necessary
R6564 T8387 T8388 compound Eomes,induction
R6565 T8388 T8386 pobj induction,for
R6566 T8389 T8391 punct ",",cooperated
R6567 T8390 T8391 advmod then,cooperated
R6568 T8391 T8379 ccomp cooperated,asked
R6569 T8392 T8391 prep with,cooperated
R6570 T8393 T8392 pobj Eomes,with
R6571 T8394 T8395 aux to,regulate
R6572 T8395 T8391 advcl regulate,cooperated
R6573 T8396 T8395 dobj transcription,regulate
R6574 T8397 T8396 prep of,transcription
R6575 T8398 T8401 det the,markers
R6576 T8399 T8400 compound effector,CTL
R6577 T8400 T8401 compound CTL,markers
R6578 T8401 T8397 pobj markers,of
R6579 T8402 T8404 nmod perforin,IFN-γ
R6580 T8403 T8402 punct ",",perforin
R6581 T8404 T8395 dobj IFN-γ,regulate
R6582 T8405 T8404 punct ",",IFN-γ
R6583 T8406 T8404 cc and,IFN-γ
R6584 T8407 T8408 compound granzyme,B.
R6585 T8408 T8410 nsubj B.,test
R6586 T8409 T8410 aux To,test
R6587 T8410 T8391 advcl test,cooperated
R6588 T8411 T8412 det this,hypothesis
R6589 T8412 T8410 dobj hypothesis,test
R6590 T8413 T8415 punct ",",used
R6591 T8414 T8415 nsubj we,used
R6592 T8415 T8415 ROOT used,used
R6593 T8416 T8417 compound chromatin,immunoprecipitation
R6594 T8417 T8415 dobj immunoprecipitation,used
R6595 T8418 T8419 punct (,ChIP
R6596 T8419 T8417 appos ChIP,immunoprecipitation
R6597 T8420 T8417 punct ),immunoprecipitation
R6598 T8421 T8415 dobj assays,used
R6599 T8422 T8423 aux to,ask
R6600 T8423 T8415 xcomp ask,used
R6601 T8424 T8428 mark whether,bound
R6602 T8425 T8428 nsubj Eomes,bound
R6603 T8426 T8425 cc and,Eomes
R6604 T8427 T8425 conj Runx3,Eomes
R6605 T8428 T8423 ccomp bound,ask
R6606 T8429 T8430 amod regulatory,regions
R6607 T8430 T8428 dobj regions,bound
R6608 T8431 T8430 prep of,regions
R6609 T8432 T8433 det the,Prf1
R6610 T8433 T8439 nmod Prf1,genes
R6611 T8434 T8433 punct ",",Prf1
R6612 T8435 T8433 conj Ifng,Prf1
R6613 T8436 T8435 punct ",",Ifng
R6614 T8437 T8435 cc and,Ifng
R6615 T8438 T8435 conj Gzmb,Ifng
R6616 T8439 T8431 pobj genes,of
R6617 T8440 T8443 punct (,D
R6618 T8441 T8443 nmod Fig.,D
R6619 T8442 T8441 nummod 3,Fig.
R6620 T8443 T8439 appos D,genes
R6621 T8444 T8423 punct ),ask
R6622 T8445 T8415 punct .,used
R6623 T8446 T8447 det Both,proteins
R6624 T8447 T8447 ROOT proteins,proteins
R6625 T8448 T8447 acl associated,proteins
R6626 T8449 T8448 prep with,associated
R6627 T8450 T8452 amod gene,regions
R6628 T8451 T8452 amod regulatory,regions
R6629 T8452 T8449 pobj regions,with
R6630 T8453 T8452 prep in,regions
R6631 T8454 T8455 amod differentiated,CTLs
R6632 T8455 T8453 pobj CTLs,in
R6633 T8456 T8447 punct .,proteins
R6634 T8457 T8458 amod Runx3,bound
R6635 T8458 T8517 ccomp bound,reported
R6636 T8459 T8458 prep to,bound
R6637 T8460 T8461 det the,Prf1
R6638 T8461 T8459 pobj Prf1,to
R6639 T8462 T8461 cc and,Prf1
R6640 T8463 T8461 conj Gzmb,Prf1
R6641 T8464 T8465 advmod transcription,start
R6642 T8465 T8470 preconj start,;
R6643 T8466 T8465 dobj sites,start
R6644 T8467 T8468 punct (,TSS
R6645 T8468 T8466 appos TSS,sites
R6646 T8469 T8466 punct ),sites
R6647 T8470 T8458 punct ;,bound
R6648 T8471 T8517 ccomp to,reported
R6649 T8472 T8474 det a,IL-2
R6650 T8473 T8474 amod known,IL-2
R6651 T8474 T8476 nmod IL-2,enhancer
R6652 T8475 T8476 amod responsive,enhancer
R6653 T8476 T8471 pobj enhancer,to
R6654 T8477 T8476 acl located,enhancer
R6655 T8478 T8477 prep near,located
R6656 T8479 T8481 nummod −,kb
R6657 T8480 T8481 nummod 1,kb
R6658 T8481 T8478 pobj kb,near
R6659 T8482 T8481 prep of,kb
R6660 T8483 T8485 det the,gene
R6661 T8484 T8485 compound Prf1,gene
R6662 T8485 T8482 pobj gene,of
R6663 T8486 T8485 punct (,gene
R6664 T8487 T8485 appos 23,gene
R6665 T8488 T8485 punct ),gene
R6666 T8489 T8471 punct ;,to
R6667 T8490 T8496 prep to,hypersensitive
R6668 T8491 T8494 det the,DNase
R6669 T8492 T8494 amod distal,DNase
R6670 T8493 T8494 compound CTL-specific,DNase
R6671 T8494 T8490 pobj DNase,to
R6672 T8495 T8496 nsubj I,hypersensitive
R6673 T8496 T8517 ccomp hypersensitive,reported
R6674 T8497 T8496 dobj site,hypersensitive
R6675 T8498 T8497 nummod 9,site
R6676 T8499 T8496 prep in,hypersensitive
R6677 T8500 T8502 det the,locus
R6678 T8501 T8502 amod Prf1,locus
R6679 T8502 T8499 pobj locus,in
R6680 T8503 T8502 punct (,locus
R6681 T8504 T8502 appos 24,locus
R6682 T8505 T8502 punct ),locus
R6683 T8506 T8517 punct ;,reported
R6684 T8507 T8517 prep to,reported
R6685 T8508 T8510 det the,promoter
R6686 T8509 T8510 compound Ifng,promoter
R6687 T8510 T8507 pobj promoter,to
R6688 T8511 T8510 prep near,promoter
R6689 T8512 T8513 det the,TSS
R6690 T8513 T8511 pobj TSS,near
R6691 T8514 T8517 punct ",",reported
R6692 T8515 T8517 mark as,reported
R6693 T8516 T8517 advmod previously,reported
R6694 T8517 T8517 ROOT reported,reported
R6695 T8518 T8517 prep for,reported
R6696 T8519 T8520 amod Th1,cells
R6697 T8520 T8518 pobj cells,for
R6698 T8521 T8522 punct (,10
R6699 T8522 T8517 npadvmod 10,reported
R6700 T8523 T8522 punct ),10
R6701 T8524 T8517 punct ;,reported
R6702 T8525 T8517 cc and,reported
R6703 T8526 T8530 prep to,hypersensitive
R6704 T8527 T8528 amod several,DNase
R6705 T8528 T8526 pobj DNase,to
R6706 T8529 T8530 nsubj I,hypersensitive
R6707 T8530 T8530 ROOT hypersensitive,hypersensitive
R6708 T8531 T8530 dobj sites,hypersensitive
R6709 T8532 T8531 prep in,sites
R6710 T8533 T8535 det the,locus
R6711 T8534 T8535 compound Ifng,locus
R6712 T8535 T8532 pobj locus,in
R6713 T8536 T8537 punct (,Fig.
R6714 T8537 T8539 nmod Fig.,D
R6715 T8538 T8539 nummod 3,D
R6716 T8539 T8530 npadvmod D,hypersensitive
R6717 T8540 T8530 cc and,hypersensitive
R6718 T8541 T8542 neg not,depicted
R6719 T8542 T8530 conj depicted,hypersensitive
R6720 T8543 T8542 punct ),depicted
R6721 T8544 T8545 punct (,25
R6722 T8545 T8530 appos 25,hypersensitive
R6723 T8546 T8530 punct ),hypersensitive
R6724 T8547 T8517 punct .,reported
R6725 T8548 T8564 nsubj Eomes,was
R6726 T8549 T8548 acl bound,Eomes
R6727 T8550 T8549 advmod primarily,bound
R6728 T8551 T8549 prep to,bound
R6729 T8552 T8554 det the,TSS
R6730 T8553 T8554 compound Prf1,TSS
R6731 T8554 T8551 pobj TSS,to
R6732 T8555 T8554 cc and,TSS
R6733 T8556 T8560 det the,enhancer
R6734 T8557 T8560 nmod −,enhancer
R6735 T8558 T8559 nummod 1,kb
R6736 T8559 T8560 compound kb,enhancer
R6737 T8560 T8554 conj enhancer,TSS
R6738 T8561 T8564 punct ;,was
R6739 T8562 T8563 det this,binding
R6740 T8563 T8564 nsubj binding,was
R6741 T8564 T8564 ROOT was,was
R6742 T8565 T8566 advmod substantially,greater
R6743 T8566 T8564 acomp greater,was
R6744 T8567 T8566 prep than,greater
R6745 T8568 T8567 pobj that,than
R6746 T8569 T8568 acl observed,that
R6747 T8570 T8569 prep at,observed
R6748 T8571 T8572 det the,promoter
R6749 T8572 T8570 pobj promoter,at
R6750 T8573 T8572 prep of,promoter
R6751 T8574 T8576 det the,gene
R6752 T8575 T8576 amod Il2rb,gene
R6753 T8576 T8573 pobj gene,of
R6754 T8577 T8576 punct ",",gene
R6755 T8578 T8581 det a,target
R6756 T8579 T8581 amod known,target
R6757 T8580 T8581 amod direct,target
R6758 T8581 T8576 appos target,gene
R6759 T8582 T8581 prep of,target
R6760 T8583 T8582 pobj Eomes,of
R6761 T8584 T8583 punct (,Eomes
R6762 T8585 T8583 appos 8,Eomes
R6763 T8586 T8583 punct ),Eomes
R6764 T8587 T8581 punct ",",target
R6765 T8588 T8581 cc and,target
R6766 T8589 T8581 conj comparable,target
R6767 T8590 T8589 prep to,comparable
R6768 T8591 T8590 pobj that,to
R6769 T8592 T8591 acl observed,that
R6770 T8593 T8592 prep at,observed
R6771 T8594 T8596 det the,TSS
R6772 T8595 T8596 compound Ifng,TSS
R6773 T8596 T8593 pobj TSS,at
R6774 T8597 T8596 punct ",",TSS
R6775 T8598 T8600 det a,target
R6776 T8599 T8600 amod known,target
R6777 T8600 T8596 appos target,TSS
R6778 T8601 T8600 prep of,target
R6779 T8602 T8603 compound T-box,proteins
R6780 T8603 T8601 pobj proteins,of
R6781 T8604 T8600 prep in,target
R6782 T8605 T8606 det both,Th1
R6783 T8606 T8604 pobj Th1,in
R6784 T8607 T8606 cc and,Th1
R6785 T8608 T8611 nummod CD8,cells
R6786 T8609 T8611 nummod +,cells
R6787 T8610 T8611 compound T,cells
R6788 T8611 T8606 conj cells,Th1
R6789 T8612 T8613 punct (,Fig.
R6790 T8613 T8615 nmod Fig.,D
R6791 T8614 T8613 nummod 3,Fig.
R6792 T8615 T8600 npadvmod D,target
R6793 T8616 T8596 punct ),TSS
R6794 T8617 T8596 punct (,TSS
R6795 T8618 T8596 appos 17,TSS
R6796 T8619 T8596 punct ),TSS
R6797 T8620 T8564 punct .,was
R6798 T8621 T8622 aux To,determine
R6799 T8622 T8640 advcl determine,expressed
R6800 T8623 T8625 mark whether,controlled
R6801 T8624 T8625 nsubj Runx3,controlled
R6802 T8625 T8622 ccomp controlled,determine
R6803 T8626 T8627 det the,expression
R6804 T8627 T8625 dobj expression,controlled
R6805 T8628 T8627 prep of,expression
R6806 T8629 T8631 nmod CTL,genes
R6807 T8630 T8631 compound effector,genes
R6808 T8631 T8628 pobj genes,of
R6809 T8632 T8625 prep through,controlled
R6810 T8633 T8634 poss its,induction
R6811 T8634 T8632 pobj induction,through
R6812 T8635 T8634 prep of,induction
R6813 T8636 T8635 pobj Eomes,of
R6814 T8637 T8640 punct ",",expressed
R6815 T8638 T8640 nsubj we,expressed
R6816 T8639 T8640 advmod retrovirally,expressed
R6817 T8640 T8640 ROOT expressed,expressed
R6818 T8641 T8640 dobj Runx3,expressed
R6819 T8642 T8641 cc and,Runx3
R6820 T8643 T8641 conj Eo-VP16,Runx3
R6821 T8644 T8640 prep in,expressed
R6822 T8645 T8648 compound CD8,cells
R6823 T8646 T8648 compound +,cells
R6824 T8647 T8648 compound T,cells
R6825 T8648 T8644 pobj cells,in
R6826 T8649 T8648 prep from,cells
R6827 T8650 T8654 amod Runx3,mice
R6828 T8651 T8654 compound −,mice
R6829 T8652 T8654 compound /,mice
R6830 T8653 T8654 compound −,mice
R6831 T8654 T8649 pobj mice,from
R6832 T8655 T8640 punct .,expressed
R6833 T8656 T8699 prep Because,used
R6834 T8657 T8656 pcomp of,Because
R6835 T8658 T8660 det the,number
R6836 T8659 T8660 amod limited,number
R6837 T8660 T8656 pobj number,Because
R6838 T8661 T8660 prep of,number
R6839 T8662 T8665 nummod CD8,cells
R6840 T8663 T8665 nummod +,cells
R6841 T8664 T8665 compound T,cells
R6842 T8665 T8661 pobj cells,of
R6843 T8666 T8660 prep in,number
R6844 T8667 T8668 det these,mice
R6845 T8668 T8666 pobj mice,in
R6846 T8669 T8660 punct ",",number
R6847 T8670 T8656 cc and,Because
R6848 T8671 T8673 mark because,saw
R6849 T8672 T8673 nsubj we,saw
R6850 T8673 T8699 advcl saw,used
R6851 T8674 T8675 det no,difference
R6852 T8675 T8673 dobj difference,saw
R6853 T8676 T8675 prep between,difference
R6854 T8677 T8685 nmod Runx3,SP
R6855 T8678 T8685 nmod −,SP
R6856 T8679 T8685 nmod /,SP
R6857 T8680 T8685 nmod −,SP
R6858 T8681 T8685 nmod CD8,SP
R6859 T8682 T8685 nmod +,SP
R6860 T8683 T8685 nmod CD4,SP
R6861 T8684 T8685 nmod −,SP
R6862 T8685 T8692 nmod SP,cells
R6863 T8686 T8685 cc and,SP
R6864 T8687 T8685 conj CD8,SP
R6865 T8688 T8692 compound +,cells
R6866 T8689 T8692 compound CD4,cells
R6867 T8690 T8692 compound +,cells
R6868 T8691 T8692 compound DP,cells
R6869 T8692 T8676 pobj cells,between
R6870 T8693 T8675 prep in,difference
R6871 T8694 T8696 poss our,experiments
R6872 T8695 T8696 amod previous,experiments
R6873 T8696 T8693 pobj experiments,in
R6874 T8697 T8699 punct ",",used
R6875 T8698 T8699 nsubj we,used
R6876 T8699 T8699 ROOT used,used
R6877 T8700 T8708 amod total,cells
R6878 T8701 T8702 amod Runx3,−
R6879 T8702 T8708 amod −,cells
R6880 T8703 T8708 amod /,cells
R6881 T8704 T8708 amod −,cells
R6882 T8705 T8708 amod CD8,cells
R6883 T8706 T8708 amod +,cells
R6884 T8707 T8708 compound T,cells
R6885 T8708 T8699 dobj cells,used
R6886 T8709 T8699 prep without,used
R6887 T8710 T8711 amod further,fractionation
R6888 T8711 T8709 pobj fractionation,without
R6889 T8712 T8699 prep as,used
R6890 T8713 T8712 pobj recipients,as
R6891 T8714 T8713 prep for,recipients
R6892 T8715 T8716 amod retroviral,transduction
R6893 T8716 T8714 pobj transduction,for
R6894 T8717 T8699 punct .,used
R6895 T8718 T8718 ROOT Reconstitution,Reconstitution
R6896 T8719 T8718 prep of,Reconstitution
R6897 T8720 T8727 nmod Runx3,cells
R6898 T8721 T8727 nmod −,cells
R6899 T8722 T8727 nmod /,cells
R6900 T8723 T8727 nmod −,cells
R6901 T8724 T8727 nmod CD8,cells
R6902 T8725 T8727 nmod +,cells
R6903 T8726 T8727 compound T,cells
R6904 T8727 T8719 pobj cells,of
R6905 T8728 T8727 prep with,cells
R6906 T8729 T8731 amod Runx3,expression
R6907 T8730 T8731 amod restored,expression
R6908 T8731 T8728 pobj expression,with
R6909 T8732 T8731 prep of,expression
R6910 T8733 T8732 pobj Eomes,of
R6911 T8734 T8736 advmod as,as
R6912 T8735 T8736 advmod well,as
R6913 T8736 T8731 cc as,expression
R6914 T8737 T8731 conj perforin,expression
R6915 T8738 T8718 punct ",",Reconstitution
R6916 T8739 T8740 compound granzyme,B
R6917 T8740 T8718 appos B,Reconstitution
R6918 T8741 T8718 punct ",",Reconstitution
R6919 T8742 T8718 cc and,Reconstitution
R6920 T8743 T8718 conj IFN-γ,Reconstitution
R6921 T8744 T8745 punct (,Fig.
R6922 T8745 T8743 appos Fig.,IFN-γ
R6923 T8746 T8745 nummod 4,Fig.
R6924 T8747 T8745 punct ",",Fig.
R6925 T8748 T8743 det A,IFN-γ
R6926 T8749 T8748 cc and,A
R6927 T8750 T8748 conj B,A
R6928 T8751 T8750 punct ),B
R6929 T8752 T8718 punct .,Reconstitution
R6930 T8753 T8757 prep In,−
R6931 T8754 T8753 pobj addition,In
R6932 T8755 T8757 punct ",",−
R6933 T8756 T8757 nsubj Runx3,−
R6934 T8757 T8757 ROOT −,−
R6935 T8758 T8761 nummod /,cells
R6936 T8759 T8761 nummod −,cells
R6937 T8760 T8761 compound T,cells
R6938 T8761 T8762 nsubj cells,showed
R6939 T8762 T8757 ccomp showed,−
R6940 T8763 T8765 det a,up-regulation
R6941 T8764 T8765 amod compensatory,up-regulation
R6942 T8765 T8762 dobj up-regulation,showed
R6943 T8766 T8765 prep of,up-regulation
R6944 T8767 T8766 pobj Runx1,of
R6945 T8768 T8767 punct ",",Runx1
R6946 T8769 T8771 nsubjpass which,suppressed
R6947 T8770 T8771 auxpass was,suppressed
R6948 T8771 T8767 relcl suppressed,Runx1
R6949 T8772 T8771 prep upon,suppressed
R6950 T8773 T8772 pobj reconstitution,upon
R6951 T8774 T8771 prep with,suppressed
R6952 T8775 T8774 pobj Runx3,with
R6953 T8776 T8762 punct ",",showed
R6954 T8777 T8762 advcl indicating,showed
R6955 T8778 T8780 mark that,is
R6956 T8779 T8780 nsubj Runx1,is
R6957 T8780 T8777 ccomp is,indicating
R6958 T8781 T8782 det a,target
R6959 T8782 T8780 attr target,is
R6960 T8783 T8782 prep of,target
R6961 T8784 T8783 pobj repression,of
R6962 T8785 T8782 prep by,target
R6963 T8786 T8785 pobj Runx3,by
R6964 T8787 T8762 punct .,showed
R6965 T8788 T8801 advmod Notably,/
R6966 T8789 T8795 punct ",",expression
R6967 T8790 T8793 nsubj Eo-VP16,up-regulate
R6968 T8791 T8793 aux did,up-regulate
R6969 T8792 T8793 neg not,up-regulate
R6970 T8793 T8795 amod up-regulate,expression
R6971 T8794 T8795 compound perforin,expression
R6972 T8795 T8801 nsubj expression,/
R6973 T8796 T8797 advmod when,expressed
R6974 T8797 T8795 advcl expressed,expression
R6975 T8798 T8797 prep in,expressed
R6976 T8799 T8800 compound Runx3,−
R6977 T8800 T8798 pobj −,in
R6978 T8801 T8801 ROOT /,/
R6979 T8802 T8803 nummod −,cells
R6980 T8803 T8801 dobj cells,/
R6981 T8804 T8801 punct ",",/
R6982 T8805 T8808 advmod even,restored
R6983 T8806 T8808 mark though,restored
R6984 T8807 T8808 nsubj it,restored
R6985 T8808 T8801 advcl restored,/
R6986 T8809 T8810 det the,capacity
R6987 T8810 T8808 dobj capacity,restored
R6988 T8811 T8812 aux to,induce
R6989 T8812 T8810 acl induce,capacity
R6990 T8813 T8814 amod IFN-γ,expression
R6991 T8814 T8812 dobj expression,induce
R6992 T8815 T8812 prep upon,induce
R6993 T8816 T8817 compound TCR,restimulation
R6994 T8817 T8812 advmod restimulation,induce
R6995 T8818 T8819 punct (,Fig.
R6996 T8819 T8817 parataxis Fig.,restimulation
R6997 T8820 T8819 nummod 4,Fig.
R6998 T8821 T8819 punct ",",Fig.
R6999 T8822 T8819 appos A,Fig.
R7000 T8823 T8822 cc and,A
R7001 T8824 T8822 conj B,A
R7002 T8825 T8824 punct ),B
R7003 T8826 T8801 punct .,/
R7004 T8827 T8828 det This,result
R7005 T8828 T8829 nsubj result,suggests
R7006 T8829 T8829 ROOT suggests,suggests
R7007 T8830 T8829 advmod strongly,suggests
R7008 T8831 T8834 mark that,requires
R7009 T8832 T8833 amod perforin,expression
R7010 T8833 T8834 nsubj expression,requires
R7011 T8834 T8829 ccomp requires,suggests
R7012 T8835 T8834 dobj Runx3,requires
R7013 T8836 T8835 cc and,Runx3
R7014 T8837 T8835 conj Eomes,Runx3
R7015 T8838 T8829 punct .,suggests
R7016 T8839 T8840 mark As,expected
R7017 T8840 T8859 advcl expected,showed
R7018 T8841 T8840 prep from,expected
R7019 T8842 T8843 poss their,defect
R7020 T8843 T8841 pobj defect,from
R7021 T8844 T8843 prep in,defect
R7022 T8845 T8844 pobj perforin,in
R7023 T8846 T8845 cc and,perforin
R7024 T8847 T8849 compound granzyme,expression
R7025 T8848 T8849 compound B,expression
R7026 T8849 T8845 conj expression,perforin
R7027 T8850 T8843 punct ",",defect
R7028 T8851 T8858 amod Runx3,cells
R7029 T8852 T8858 nmod −,cells
R7030 T8853 T8858 nmod /,cells
R7031 T8854 T8858 nmod −,cells
R7032 T8855 T8858 nmod CD8,cells
R7033 T8856 T8858 nmod +,cells
R7034 T8857 T8858 compound T,cells
R7035 T8858 T8859 nsubj cells,showed
R7036 T8859 T8859 ROOT showed,showed
R7037 T8860 T8862 amod defective,activity
R7038 T8861 T8862 compound cytolytic,activity
R7039 T8862 T8859 dobj activity,showed
R7040 T8863 T8859 prep in,showed
R7041 T8864 T8867 det a,reaction
R7042 T8865 T8867 amod mixed,reaction
R7043 T8866 T8867 compound lymphocyte,reaction
R7044 T8867 T8863 pobj reaction,in
R7045 T8868 T8867 punct (,reaction
R7046 T8869 T8867 appos 12,reaction
R7047 T8870 T8867 punct ),reaction
R7048 T8871 T8859 punct .,showed
R7049 T8872 T8877 advmod However,/
R7050 T8873 T8877 punct ",",/
R7051 T8874 T8876 nmod TCR-stimulated,−
R7052 T8875 T8876 amod Runx3,−
R7053 T8876 T8877 nsubj −,/
R7054 T8877 T8877 ROOT /,/
R7055 T8878 T8881 nummod −,cells
R7056 T8879 T8881 nummod CD8,cells
R7057 T8880 T8881 compound +,cells
R7058 T8881 T8882 nsubj cells,were
R7059 T8882 T8877 ccomp were,/
R7060 T8883 T8884 advmod as,effective
R7061 T8884 T8882 acomp effective,were
R7062 T8885 T8884 prep as,effective
R7063 T8886 T8887 compound WT,cells
R7064 T8887 T8885 pobj cells,as
R7065 T8888 T8887 prep in,cells
R7066 T8889 T8888 pcomp killing,in
R7067 T8890 T8891 compound tumor,cells
R7068 T8891 T8889 dobj cells,killing
R7069 T8892 T8889 prep in,killing
R7070 T8893 T8896 det a,assay
R7071 T8894 T8896 amod redirected,assay
R7072 T8895 T8896 compound CTL,assay
R7073 T8896 T8892 pobj assay,in
R7074 T8897 T8896 punct (,assay
R7075 T8898 T8896 appos 12,assay
R7076 T8899 T8896 punct ),assay
R7077 T8900 T8877 punct .,/
R7078 T8901 T8913 advmod Furthermore,/
R7079 T8902 T8913 punct ",",/
R7080 T8903 T8905 compound CD8,cells
R7081 T8904 T8905 compound +,cells
R7082 T8905 T8913 nsubj cells,/
R7083 T8906 T8905 prep from,cells
R7084 T8907 T8909 det the,cavity
R7085 T8908 T8909 amod peritoneal,cavity
R7086 T8909 T8906 pobj cavity,from
R7087 T8910 T8909 prep of,cavity
R7088 T8911 T8912 compound Runx3,−
R7089 T8912 T8910 pobj −,of
R7090 T8913 T8913 ROOT /,/
R7091 T8914 T8915 nummod −,mice
R7092 T8915 T8913 dobj mice,/
R7093 T8916 T8915 acl immunized,mice
R7094 T8917 T8916 prep with,immunized
R7095 T8918 T8920 amod certain,cells
R7096 T8919 T8920 compound tumor,cells
R7097 T8920 T8917 pobj cells,with
R7098 T8921 T8922 advmod effectively,killed
R7099 T8922 T8913 conj killed,/
R7100 T8923 T8924 det these,targets
R7101 T8924 T8922 dobj targets,killed
R7102 T8925 T8926 punct (,13
R7103 T8926 T8922 npadvmod 13,killed
R7104 T8927 T8926 punct ),13
R7105 T8928 T8913 punct .,/
R7106 T8929 T8943 advmod Therefore,/
R7107 T8930 T8943 punct ",",/
R7108 T8931 T8938 mark although,is
R7109 T8932 T8938 nsubj activation,is
R7110 T8933 T8932 prep of,activation
R7111 T8934 T8937 det the,machinery
R7112 T8935 T8937 compound perforin/granzyme,machinery
R7113 T8936 T8937 compound B,machinery
R7114 T8937 T8933 pobj machinery,of
R7115 T8938 T8943 advcl is,/
R7116 T8939 T8938 acomp defective,is
R7117 T8940 T8939 prep in,defective
R7118 T8941 T8942 compound Runx3,−
R7119 T8942 T8940 pobj −,in
R7120 T8943 T8951 ccomp /,are
R7121 T8944 T8947 nummod −,cells
R7122 T8945 T8947 nummod CD8,cells
R7123 T8946 T8947 compound +,cells
R7124 T8947 T8943 dobj cells,/
R7125 T8948 T8951 punct ",",are
R7126 T8949 T8950 det these,cells
R7127 T8950 T8951 nsubj cells,are
R7128 T8951 T8951 ROOT are,are
R7129 T8952 T8951 neg not,are
R7130 T8953 T8954 advmod entirely,devoid
R7131 T8954 T8951 acomp devoid,are
R7132 T8955 T8954 prep of,devoid
R7133 T8956 T8957 amod cytolytic,activity
R7134 T8957 T8955 pobj activity,of
R7135 T8958 T8951 cc and,are
R7136 T8959 T8962 aux could,kill
R7137 T8960 T8962 advmod still,kill
R7138 T8961 T8962 advmod effectively,kill
R7139 T8962 T8951 conj kill,are
R7140 T8963 T8962 dobj targets,kill
R7141 T8964 T8962 punct ",",kill
R7142 T8965 T8966 advmod possibly,by
R7143 T8966 T8962 prep by,kill
R7144 T8967 T8968 amod alternative,mechanisms
R7145 T8968 T8966 pobj mechanisms,by
R7146 T8969 T8970 amod such,as
R7147 T8970 T8968 prep as,mechanisms
R7148 T8971 T8972 det the,Fas
R7149 T8972 T8970 pobj Fas,as
R7150 T8973 T8974 compound Fas,ligand
R7151 T8974 T8975 compound ligand,pathway
R7152 T8975 T8962 dobj pathway,kill
R7153 T8976 T8962 punct .,kill
R15553 T20185 T20186 amod Key,role
R15554 T20186 T20186 ROOT role,role
R15555 T20187 T20186 prep for,role
R15556 T20188 T20187 pobj Runx3,for
R15557 T20189 T20186 prep in,role
R15558 T20190 T20191 compound effector,CTL
R15559 T20191 T20192 compound CTL,differentiation
R15560 T20192 T20189 pobj differentiation,in
R15561 T20193 T20186 punct .,role
R15562 T20194 T20198 punct (,analysis
R15563 T20195 T20198 nmod A,analysis
R15564 T20196 T20195 punct ),A
R15565 T20197 T20198 amod Western,analysis
R15566 T20198 T20212 nsubj analysis,/
R15567 T20199 T20198 prep of,analysis
R15568 T20200 T20199 pobj Runx3,of
R15569 T20201 T20200 punct ",",Runx3
R15570 T20202 T20200 conj Eomes,Runx3
R15571 T20203 T20202 punct ",",Eomes
R15572 T20204 T20202 conj T-bet,Eomes
R15573 T20205 T20204 punct ",",T-bet
R15574 T20206 T20204 cc and,T-bet
R15575 T20207 T20208 compound perforin,expression
R15576 T20208 T20198 conj expression,analysis
R15577 T20209 T20198 prep in,analysis
R15578 T20210 T20211 compound Runx3,+
R15579 T20211 T20209 pobj +,in
R15580 T20212 T20212 ROOT /,/
R15581 T20213 T20223 nummod +,cells
R15582 T20214 T20213 cc versus,+
R15583 T20215 T20223 nmod Runx3,cells
R15584 T20216 T20223 nmod −,cells
R15585 T20217 T20223 nmod /,cells
R15586 T20218 T20223 nmod −,cells
R15587 T20219 T20223 nmod CD8,cells
R15588 T20220 T20223 nmod +,cells
R15589 T20221 T20223 nmod SP,cells
R15590 T20222 T20223 compound T,cells
R15591 T20223 T20224 nsubj cells,differentiated
R15592 T20224 T20212 ccomp differentiated,/
R15593 T20225 T20224 prep for,differentiated
R15594 T20226 T20228 nummod 6,β-Actin
R15595 T20227 T20228 compound d.,β-Actin
R15596 T20228 T20225 pobj β-Actin,for
R15597 T20229 T20230 auxpass was,used
R15598 T20230 T20212 conj used,/
R15599 T20231 T20230 prep as,used
R15600 T20232 T20234 det a,control
R15601 T20233 T20234 compound loading,control
R15602 T20234 T20231 pobj control,as
R15603 T20235 T20212 punct .,/
R15604 T20236 T20241 punct (,analysis
R15605 T20237 T20241 nmod B,analysis
R15606 T20238 T20237 punct ),B
R15607 T20239 T20240 compound Northern,blot
R15608 T20240 T20241 compound blot,analysis
R15609 T20241 T20249 nsubj analysis,/
R15610 T20242 T20241 prep of,analysis
R15611 T20243 T20244 compound Prf1,mRNA
R15612 T20244 T20245 compound mRNA,expression
R15613 T20245 T20242 pobj expression,of
R15614 T20246 T20241 prep in,analysis
R15615 T20247 T20248 compound Runx3,+
R15616 T20248 T20246 pobj +,in
R15617 T20249 T20267 ccomp /,used
R15618 T20250 T20259 nummod +,cells
R15619 T20251 T20250 cc versus,+
R15620 T20252 T20259 nmod Runx3,cells
R15621 T20253 T20259 nmod −,cells
R15622 T20254 T20259 nmod /,cells
R15623 T20255 T20259 nmod −,cells
R15624 T20256 T20259 nmod CD8,cells
R15625 T20257 T20259 nmod +,cells
R15626 T20258 T20259 compound T,cells
R15627 T20259 T20260 nsubj cells,differentiated
R15628 T20260 T20249 ccomp differentiated,/
R15629 T20261 T20260 prep for,differentiated
R15630 T20262 T20264 nummod 6,β
R15631 T20263 T20264 compound d.,β
R15632 T20264 T20261 pobj β,for
R15633 T20265 T20267 nsubjpass Actin,used
R15634 T20266 T20267 auxpass was,used
R15635 T20267 T20267 ROOT used,used
R15636 T20268 T20267 prep as,used
R15637 T20269 T20271 det a,control
R15638 T20270 T20271 compound loading,control
R15639 T20271 T20268 pobj control,as
R15640 T20272 T20267 punct .,used
R15641 T20273 T20274 punct (,C
R15642 T20274 T20276 compound C,Expression
R15643 T20275 T20274 punct ),C
R15644 T20276 T20276 ROOT Expression,Expression
R15645 T20277 T20276 prep of,Expression
R15646 T20278 T20279 compound granzyme,B
R15647 T20279 T20277 pobj B,of
R15648 T20280 T20279 punct ",",B
R15649 T20281 T20279 appos IFN-γ,B
R15650 T20282 T20281 punct ",",IFN-γ
R15651 T20283 T20281 conj TNF,IFN-γ
R15652 T20284 T20283 punct ",",TNF
R15653 T20285 T20283 cc and,TNF
R15654 T20286 T20283 conj IL-2,TNF
R15655 T20287 T20276 prep by,Expression
R15656 T20288 T20287 pcomp resting,by
R15657 T20289 T20288 cc or,resting
R15658 T20290 T20288 conj restimulated,resting
R15659 T20291 T20290 punct (,restimulated
R15660 T20292 T20293 nummod 6,h
R15661 T20293 T20290 appos h,restimulated
R15662 T20294 T20290 punct ),restimulated
R15663 T20295 T20298 amod Runx3,+
R15664 T20296 T20298 compound +,+
R15665 T20297 T20298 compound /,+
R15666 T20298 T20298 ROOT +,+
R15667 T20299 T20302 prep versus,/
R15668 T20300 T20301 compound Runx3,−
R15669 T20301 T20302 nsubj −,/
R15670 T20302 T20302 ROOT /,/
R15671 T20303 T20308 nummod −,cells
R15672 T20304 T20308 nummod CD8,cells
R15673 T20305 T20308 compound +,cells
R15674 T20306 T20307 compound SP,T
R15675 T20307 T20308 compound T,cells
R15676 T20308 T20309 nsubj cells,differentiated
R15677 T20309 T20302 acl differentiated,/
R15678 T20310 T20309 prep for,differentiated
R15679 T20311 T20312 nummod 6,d
R15680 T20312 T20310 pobj d,for
R15681 T20313 T20309 punct .,differentiated
R15682 T20314 T20317 det The,line
R15683 T20315 T20317 amod vertical,line
R15684 T20316 T20317 amod gray,line
R15685 T20317 T20318 nsubj line,indicates
R15686 T20318 T20318 ROOT indicates,indicates
R15687 T20319 T20322 det the,MFI
R15688 T20320 T20322 compound granzyme,MFI
R15689 T20321 T20322 compound B,MFI
R15690 T20322 T20318 dobj MFI,indicates
R15691 T20323 T20322 prep for,MFI
R15692 T20324 T20325 compound WT,GFP
R15693 T20325 T20327 compound GFP,cells
R15694 T20326 T20327 compound +,cells
R15695 T20327 T20323 pobj cells,for
R15696 T20328 T20318 punct .,indicates
R15697 T20329 T20333 nsubj Results,are
R15698 T20330 T20329 prep in,Results
R15699 T20331 T20330 pobj A,in
R15700 T20332 T20333 nsubj C,are
R15701 T20333 T20333 ROOT are,are
R15702 T20334 T20333 attr representative,are
R15703 T20335 T20334 prep of,representative
R15704 T20336 T20338 nummod two,experiments
R15705 T20337 T20338 amod independent,experiments
R15706 T20338 T20335 pobj experiments,of
R15707 T20339 T20333 punct .,are
R15708 T20340 T20344 punct (,analysis
R15709 T20341 T20344 compound D,analysis
R15710 T20342 T20343 punct ),ChIP
R15711 T20343 T20344 compound ChIP,analysis
R15712 T20344 T20344 ROOT analysis,analysis
R15713 T20345 T20344 prep of,analysis
R15714 T20346 T20345 pcomp binding,of
R15715 T20347 T20346 prep of,binding
R15716 T20348 T20349 compound endogenous,Runx3
R15717 T20349 T20347 pobj Runx3,of
R15718 T20350 T20349 cc and,Runx3
R15719 T20351 T20349 conj Eomes,Runx3
R15720 T20352 T20344 prep to,analysis
R15721 T20353 T20355 det the,locus
R15722 T20354 T20355 amod Prf1,locus
R15723 T20355 T20352 pobj locus,to
R15724 T20356 T20344 punct .,analysis
R15725 T20357 T20364 nsubjpass Enrichment,evaluated
R15726 T20358 T20357 prep of,Enrichment
R15727 T20359 T20362 det the,regions
R15728 T20360 T20362 amod indicated,regions
R15729 T20361 T20362 amod genomic,regions
R15730 T20362 T20358 pobj regions,of
R15731 T20363 T20364 auxpass was,evaluated
R15732 T20364 T20364 ROOT evaluated,evaluated
R15733 T20365 T20364 agent by,evaluated
R15734 T20366 T20367 amod real-time,PCR
R15735 T20367 T20365 pobj PCR,by
R15736 T20368 T20367 prep of,PCR
R15737 T20369 T20368 pobj DNA,of
R15738 T20370 T20364 prep from,evaluated
R15739 T20371 T20370 pobj immunoprecipitated,from
R15740 T20372 T20371 cc and,immunoprecipitated
R15741 T20373 T20374 compound input,chromatin
R15742 T20374 T20371 conj chromatin,immunoprecipitated
R15743 T20375 T20364 punct .,evaluated
R15744 T20376 T20377 det The,data
R15745 T20377 T20378 nsubj data,are
R15746 T20378 T20378 ROOT are,are
R15747 T20379 T20380 det the,means
R15748 T20380 T20378 attr means,are
R15749 T20381 T20380 prep of,means
R15750 T20382 T20381 pcomp duplicate,of
R15751 T20383 T20382 dobj measurements,duplicate
R15752 T20384 T20382 prep from,duplicate
R15753 T20385 T20387 nummod two,preparations
R15754 T20386 T20387 amod chromatin,preparations
R15755 T20387 T20384 pobj preparations,from
R15756 T20388 T20387 prep from,preparations
R15757 T20389 T20395 nummod two,differentiations
R15758 T20390 T20395 amod independent,differentiations
R15759 T20391 T20395 compound CD8,differentiations
R15760 T20392 T20395 nummod +,differentiations
R15761 T20393 T20394 compound T,cell
R15762 T20394 T20395 compound cell,differentiations
R15763 T20395 T20388 pobj differentiations,from
R15764 T20396 T20378 punct .,are
R15765 T20397 T20398 det The,efficiency
R15766 T20398 T20410 nsubj efficiency,was
R15767 T20399 T20398 prep of,efficiency
R15768 T20400 T20399 pobj recovery,of
R15769 T20401 T20400 prep of,recovery
R15770 T20402 T20401 pobj input,of
R15771 T20403 T20402 prep for,input
R15772 T20404 T20407 det the,region
R15773 T20405 T20407 amod −,region
R15774 T20406 T20407 amod 1-kb,region
R15775 T20407 T20403 pobj region,for
R15776 T20408 T20407 prep of,region
R15777 T20409 T20408 pobj Prf1,of
R15778 T20410 T20410 ROOT was,was
R15779 T20411 T20412 nummod 0.97,%
R15780 T20412 T20410 attr %,was
R15781 T20413 T20410 prep for,was
R15782 T20414 T20416 det the,ChIP
R15783 T20415 T20416 compound Runx3,ChIP
R15784 T20416 T20413 pobj ChIP,for
R15785 T20417 T20410 cc and,was
R15786 T20418 T20419 nummod 0.5,%
R15787 T20419 T20410 conj %,was
R15788 T20420 T20419 prep for,%
R15789 T20421 T20423 det the,ChIP
R15790 T20422 T20423 compound Eomes,ChIP
R15791 T20423 T20420 pobj ChIP,for
R15792 T20424 T20410 punct .,was
R16018 T20967 T20968 amod Runx3,controls
R16019 T20968 T20968 ROOT controls,controls
R16020 T20969 T20968 appos Eomes,controls
R16021 T20970 T20969 punct ",",Eomes
R16022 T20971 T20969 appos perforin,Eomes
R16023 T20972 T20969 punct ",",Eomes
R16024 T20973 T20974 compound granzyme,B
R16025 T20974 T20969 conj B,Eomes
R16026 T20975 T20969 punct ",",Eomes
R16027 T20976 T20969 cc and,Eomes
R16028 T20977 T20978 compound IFN-γ,expression
R16029 T20978 T20969 conj expression,Eomes
R16030 T20979 T20978 prep in,expression
R16031 T20980 T20981 compound effector,CTLs
R16032 T20981 T20979 pobj CTLs,in
R16033 T20982 T20968 punct .,controls
R16034 T20983 T20986 amod Runx3,+
R16035 T20984 T20986 compound +,+
R16036 T20985 T20986 compound /,+
R16037 T20986 T20997 nsubjpass +,activated
R16038 T20987 T20986 cc or,+
R16039 T20988 T20995 amod Runx3,cells
R16040 T20989 T20995 nmod −,cells
R16041 T20990 T20995 nmod /,cells
R16042 T20991 T20995 nmod −,cells
R16043 T20992 T20995 nmod CD8,cells
R16044 T20993 T20995 nmod +,cells
R16045 T20994 T20995 compound T,cells
R16046 T20995 T20986 conj cells,+
R16047 T20996 T20997 auxpass were,activated
R16048 T20997 T20997 ROOT activated,activated
R16049 T20998 T20997 cc and,activated
R16050 T20999 T20997 conj transduced,activated
R16051 T21000 T20999 prep with,transduced
R16052 T21001 T21000 pobj retroviruses,with
R16053 T21002 T21001 acl bearing,retroviruses
R16054 T21003 T21006 det an,cassette
R16055 T21004 T21006 amod empty,cassette
R16056 T21005 T21006 compound IRES-GFP,cassette
R16057 T21006 T21002 dobj cassette,bearing
R16058 T21007 T21006 punct (,cassette
R16059 T21008 T21006 appos GFP,cassette
R16060 T21009 T21008 punct ),GFP
R16061 T21010 T21006 cc or,cassette
R16062 T21011 T21012 advmod also,encoding
R16063 T21012 T20997 advcl encoding,activated
R16064 T21013 T21012 dobj Eomes-VP16,encoding
R16065 T21014 T21015 punct (,Eo-VP16
R16066 T21015 T21013 appos Eo-VP16,Eomes-VP16
R16067 T21016 T21015 punct ),Eo-VP16
R16068 T21017 T21013 cc or,Eomes-VP16
R16069 T21018 T21013 conj Myc-Runx3,Eomes-VP16
R16070 T21019 T21020 punct (,Runx3
R16071 T21020 T21018 appos Runx3,Myc-Runx3
R16072 T21021 T21020 punct ),Runx3
R16073 T21022 T20997 punct .,activated
R16074 T21023 T21024 det The,frequency
R16075 T21024 T21031 nsubj frequency,was
R16076 T21025 T21024 prep of,frequency
R16077 T21026 T21027 amod transduced,cells
R16078 T21027 T21025 pobj cells,of
R16079 T21028 T21024 prep in,frequency
R16080 T21029 T21030 det the,cultures
R16081 T21030 T21028 pobj cultures,in
R16082 T21031 T21031 ROOT was,was
R16083 T21032 T21031 acomp equivalent,was
R16084 T21033 T21032 prep for,equivalent
R16085 T21034 T21035 det all,constructs
R16086 T21035 T21033 pobj constructs,for
R16087 T21036 T21035 punct (,constructs
R16088 T21037 T21038 nmod ∼,75
R16089 T21038 T21035 appos 75,constructs
R16090 T21039 T21040 nummod 90,%
R16091 T21040 T21043 compound %,cells
R16092 T21041 T21043 compound GFP,cells
R16093 T21042 T21043 nummod +,cells
R16094 T21043 T21035 appos cells,constructs
R16095 T21044 T21046 punct ;,depicted
R16096 T21045 T21046 neg not,depicted
R16097 T21046 T21031 conj depicted,was
R16098 T21047 T21046 punct ),depicted
R16099 T21048 T21031 punct .,was
R16100 T21049 T21062 punct (,analyzed
R16101 T21050 T21053 nmod A,expression
R16102 T21051 T21050 punct ),A
R16103 T21052 T21053 compound Protein,expression
R16104 T21053 T21062 nsubjpass expression,analyzed
R16105 T21054 T21053 prep in,expression
R16106 T21055 T21056 amod whole-cell,extracts
R16107 T21056 T21054 pobj extracts,in
R16108 T21057 T21058 punct (,day
R16109 T21058 T21053 appos day,expression
R16110 T21059 T21058 nummod 6,day
R16111 T21060 T21053 punct ),expression
R16112 T21061 T21062 auxpass was,analyzed
R16113 T21062 T21062 ROOT analyzed,analyzed
R16114 T21063 T21062 agent by,analyzed
R16115 T21064 T21063 pcomp immunoblotting,by
R16116 T21065 T21062 punct .,analyzed
R16117 T21066 T21072 nsubjpass Overexpression,detected
R16118 T21067 T21066 prep of,Overexpression
R16119 T21068 T21067 pobj Eomes-VP16,of
R16120 T21069 T21072 aux can,detected
R16121 T21070 T21072 neg not,detected
R16122 T21071 T21072 auxpass be,detected
R16123 T21072 T21072 ROOT detected,detected
R16124 T21073 T21072 prep with,detected
R16125 T21074 T21076 det the,antibody
R16126 T21075 T21076 compound Eomes,antibody
R16127 T21076 T21073 pobj antibody,with
R16128 T21077 T21072 punct ",",detected
R16129 T21078 T21082 mark as,is
R16130 T21079 T21081 det the,epitope
R16131 T21080 T21081 amod C-terminal,epitope
R16132 T21081 T21082 nsubj epitope,is
R16133 T21082 T21072 advcl is,detected
R16134 T21083 T21082 prep within,is
R16135 T21084 T21085 det the,region
R16136 T21085 T21083 pobj region,within
R16137 T21086 T21089 nsubjpass that,replaced
R16138 T21087 T21089 aux has,replaced
R16139 T21088 T21089 auxpass been,replaced
R16140 T21089 T21085 relcl replaced,region
R16141 T21090 T21089 prep with,replaced
R16142 T21091 T21094 det the,domain
R16143 T21092 T21094 compound VP16,domain
R16144 T21093 T21094 compound transactivation,domain
R16145 T21094 T21090 pobj domain,with
R16146 T21095 T21072 punct .,detected
R16147 T21096 T21099 punct (,Expression
R16148 T21097 T21099 nmod B,Expression
R16149 T21098 T21097 punct ),B
R16150 T21099 T21099 ROOT Expression,Expression
R16151 T21100 T21099 prep of,Expression
R16152 T21101 T21102 compound granzyme,B
R16153 T21102 T21100 pobj B,of
R16154 T21103 T21102 cc and,B
R16155 T21104 T21102 conj IFN-γ,B
R16156 T21105 T21099 prep after,Expression
R16157 T21106 T21105 pobj culture,after
R16158 T21107 T21099 prep for,Expression
R16159 T21108 T21107 pobj 6,for
R16160 T21109 T21120 nsubjpass d,determined
R16161 T21110 T21109 cc and,d
R16162 T21111 T21109 conj restimulation,d
R16163 T21112 T21111 prep for,restimulation
R16164 T21113 T21114 nummod 4,h
R16165 T21114 T21112 pobj h,for
R16166 T21115 T21114 prep with,h
R16167 T21116 T21115 pobj PMA,with
R16168 T21117 T21116 cc and,PMA
R16169 T21118 T21116 conj ionomycin,PMA
R16170 T21119 T21120 auxpass was,determined
R16171 T21120 T21120 ROOT determined,determined
R16172 T21121 T21120 agent by,determined
R16173 T21122 T21123 amod intracellular,staining
R16174 T21123 T21121 pobj staining,by
R16175 T21124 T21120 punct .,determined
R16176 T21125 T21126 det The,percentage
R16177 T21126 T21132 nsubjpass percentage,shown
R16178 T21127 T21126 prep of,percentage
R16179 T21128 T21129 advmod positively,stained
R16180 T21129 T21130 amod stained,cells
R16181 T21130 T21127 pobj cells,of
R16182 T21131 T21132 auxpass is,shown
R16183 T21132 T21153 ccomp shown,shown
R16184 T21133 T21132 prep above,shown
R16185 T21134 T21135 det the,gate
R16186 T21135 T21133 pobj gate,above
R16187 T21136 T21153 punct ;,shown
R16188 T21137 T21140 det the,intensity
R16189 T21138 T21140 amod mean,intensity
R16190 T21139 T21140 compound fluorescence,intensity
R16191 T21140 T21153 nsubjpass intensity,shown
R16192 T21141 T21142 punct (,MFI
R16193 T21142 T21140 appos MFI,intensity
R16194 T21143 T21142 punct ),MFI
R16195 T21144 T21142 prep of,MFI
R16196 T21145 T21146 compound granzyme,B
R16197 T21146 T21144 pobj B,of
R16198 T21147 T21140 conj staining,intensity
R16199 T21148 T21147 prep for,staining
R16200 T21149 T21151 det the,population
R16201 T21150 T21151 amod total,population
R16202 T21151 T21148 pobj population,for
R16203 T21152 T21153 auxpass is,shown
R16204 T21153 T21153 ROOT shown,shown
R16205 T21154 T21153 prep below,shown
R16206 T21155 T21156 det the,gate
R16207 T21156 T21154 pobj gate,below
R16208 T21157 T21153 punct .,shown
R16209 T21158 T21161 det The,lines
R16210 T21159 T21161 amod vertical,lines
R16211 T21160 T21161 amod gray,lines
R16212 T21161 T21162 nsubj lines,indicate
R16213 T21162 T21162 ROOT indicate,indicate
R16214 T21163 T21164 det the,MFI
R16215 T21164 T21162 dobj MFI,indicate
R16216 T21165 T21162 prep for,indicate
R16217 T21166 T21167 compound WT,GFP
R16218 T21167 T21169 compound GFP,cells
R16219 T21168 T21169 compound +,cells
R16220 T21169 T21165 pobj cells,for
R16221 T21170 T21162 punct .,indicate
R16222 T21171 T21172 nsubj Results,are
R16223 T21172 T21172 ROOT are,are
R16224 T21173 T21172 attr representative,are
R16225 T21174 T21173 prep of,representative
R16226 T21175 T21176 advmod at,least
R16227 T21176 T21177 advmod least,two
R16228 T21177 T21179 nummod two,experiments
R16229 T21178 T21179 amod independent,experiments
R16230 T21179 T21174 pobj experiments,of
R16231 T21180 T21172 punct .,are
R16232 T21181 T21182 punct (,C
R16233 T21182 T21185 nmod C,diagram
R16234 T21183 T21182 punct ),C
R16235 T21184 T21185 amod Schematic,diagram
R16236 T21185 T21185 ROOT diagram,diagram
R16237 T21186 T21185 prep of,diagram
R16238 T21187 T21189 det the,network
R16239 T21188 T21189 amod transcriptional,network
R16240 T21189 T21186 pobj network,of
R16241 T21190 T21189 acl involving,network
R16242 T21191 T21190 dobj Runx3,involving
R16243 T21192 T21191 cc and,Runx3
R16244 T21193 T21191 conj T-box,Runx3
R16245 T21194 T21186 pobj factors,of
R16246 T21195 T21185 punct .,diagram
R16247 T21196 T21198 nsubjpass T-bet,induced
R16248 T21197 T21198 auxpass is,induced
R16249 T21198 T21198 ROOT induced,induced
R16250 T21199 T21198 agent by,induced
R16251 T21200 T21201 compound TCR,signals
R16252 T21201 T21199 pobj signals,by
R16253 T21202 T21198 cc and,induced
R16254 T21203 T21198 conj is,induced
R16255 T21204 T21203 acomp essential,is
R16256 T21205 T21204 prep for,essential
R16257 T21206 T21208 amod early,expression
R16258 T21207 T21208 amod IFN-γ,expression
R16259 T21208 T21205 pobj expression,for
R16260 T21209 T21203 punct .,is
R16261 T21210 T21211 nsubj Runx3,is
R16262 T21211 T21211 ROOT is,is
R16263 T21212 T21211 acomp present,is
R16264 T21213 T21212 prep in,present
R16265 T21214 T21218 amod naive,cells
R16266 T21215 T21218 nmod CD8,cells
R16267 T21216 T21218 nummod +,cells
R16268 T21217 T21218 compound T,cells
R16269 T21218 T21213 pobj cells,in
R16270 T21219 T21211 cc and,is
R16271 T21220 T21211 conj represses,is
R16272 T21221 T21220 dobj Runx1,represses
R16273 T21222 T21220 cc and,represses
R16274 T21223 T21220 conj induces,represses
R16275 T21224 T21223 dobj Eomes,induces
R16276 T21225 T21224 punct ",",Eomes
R16277 T21226 T21224 appos perforin,Eomes
R16278 T21227 T21224 punct ",",Eomes
R16279 T21228 T21229 compound granzyme,B
R16280 T21229 T21224 conj B,Eomes
R16281 T21230 T21220 punct ",",represses
R16282 T21231 T21220 cc and,represses
R16283 T21232 T21233 compound IFN-γ,expression
R16284 T21233 T21220 conj expression,represses
R16285 T21234 T21211 punct .,is
R16286 T21235 T21237 nsubj Eomes,participate
R16287 T21236 T21237 aux may,participate
R16288 T21237 T21237 ROOT participate,participate
R16289 T21238 T21237 prep in,participate
R16290 T21239 T21238 pcomp sustaining,in
R16291 T21240 T21242 amod late,expression
R16292 T21241 T21242 amod IFN-γ,expression
R16293 T21242 T21239 dobj expression,sustaining
R16294 T21243 T21237 punct ",",participate
R16295 T21244 T21254 mark whereas,cooperate
R16324 T21273 T21263 cc but,indicates
R16325 T21274 T21275 neg not,granzyme
R16326 T21275 T21263 conj granzyme,indicates
R16327 T21276 T21278 compound B,expression
R16328 T21277 T21278 compound protein,expression
R16329 T21278 T21275 dobj expression,granzyme
R16330 T21279 T21263 punct .,indicates
R16296 T21245 T21254 nsubj Runx3,cooperate
R16297 T21246 T21245 cc and,Runx3
R16298 T21247 T21245 conj Eomes,Runx3
R16299 T21248 T21251 punct (,T-bet
R16300 T21249 T21251 cc but,T-bet
R16301 T21250 T21251 neg not,T-bet
R16302 T21251 T21245 conj T-bet,Runx3
R16303 T21252 T21251 punct ),T-bet
R16304 T21253 T21254 aux may,cooperate
R16305 T21254 T21237 advcl cooperate,participate
R16306 T21255 T21256 aux to,activate
R16307 T21256 T21254 advcl activate,cooperate
R16308 T21257 T21258 amod perforin,expression
R16309 T21258 T21256 dobj expression,activate
R16310 T21259 T21237 punct .,participate
R16311 T21260 T21262 det The,line
R16312 T21261 T21262 amod dotted,line
R16313 T21262 T21263 nsubj line,indicates
R16314 T21263 T21263 ROOT indicates,indicates
R16315 T21264 T21266 det the,effect
R16316 T21265 T21266 amod partial,effect
R16317 T21266 T21263 dobj effect,indicates
R16318 T21267 T21266 prep of,effect
R16319 T21268 T21269 amod T-bet,deficiency
R16320 T21269 T21267 pobj deficiency,of
R16321 T21270 T21269 prep on,deficiency
R16322 T21271 T21272 compound Gzmb,mRNA
R16323 T21272 T21270 pobj mRNA,on

UBERON-AE

Id Subject Object Predicate Lexical cue
T7584 7291-7308 http://purl.obolibrary.org/obo/UBERON_0001179 denotes peritoneal cavity

GO-BP

Id Subject Object Predicate Lexical cue
T7986 2316-2336 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiation
T7987 3026-3039 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7988 3167-3180 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7989 3532-3545 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7990 3678-3692 http://purl.obolibrary.org/obo/GO_0002524 denotes hypersensitive
T7991 3825-3839 http://purl.obolibrary.org/obo/GO_0002524 denotes hypersensitive
T7992 4673-4685 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T7993 4884-4894 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T7994 5176-5179 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T7995 7138-7141 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T7996 7197-7213 http://purl.obolibrary.org/obo/GO_0001906 denotes cells in killing
T20181 1315-1335 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiated
T20182 1470-1490 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiated
T20183 1658-1678 http://purl.obolibrary.org/obo/GO_0030154 denotes cells differentiated
T20184 2139-2160 http://purl.obolibrary.org/obo/GO_0030154 denotes cell differentiations
T20963 5933-5948 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T20964 6445-6460 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T20965 6524-6527 http://purl.obolibrary.org/obo/GO_0006283 denotes TCR
T20966 6528-6535 http://purl.obolibrary.org/obo/GO_0023052 denotes signals

GO-MF

Id Subject Object Predicate Lexical cue
T10031 1090-1094 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T10032 3576-3580 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T10033 2501-2505 http://purl.obolibrary.org/obo/GO_0005136 denotes IL-4
T10034 3950-3972 http://purl.obolibrary.org/obo/GO_0035326 denotes enhancer; this binding
T10035 3965-3972 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10036 7660-7666 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T20465 1585-1589 http://purl.obolibrary.org/obo/GO_0005134 denotes IL-2
T20466 1846-1853 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T21621 5839-5847 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody

GO-CC

Id Subject Object Predicate Lexical cue
T10037 158-163 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10038 238-243 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10039 332-337 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10040 591-596 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10041 762-767 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10042 850-855 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10043 906-911 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10044 1106-1111 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10045 2802-2807 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10046 3790-3795 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20467 1315-1320 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20468 1470-1475 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20469 1658-1663 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20470 1752-1757 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T20471 2139-2143 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20472 2019-2028 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T20473 2088-2097 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T21622 5415-5420 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21623 5598-5603 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21624 5668-5673 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21625 6146-6151 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21626 6341-6346 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21627 6614-6619 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21628 5839-5847 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T21629 5839-5847 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T21630 6085-6098 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T21631 6524-6527 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10047 4194-4199 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10048 4378-4383 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10049 4444-4449 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10050 4543-4548 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10051 4608-4613 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10052 4721-4726 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10053 4853-4858 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10054 5100-5105 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10055 7050-7055 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10056 7167-7172 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10057 7197-7202 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10058 7220-7225 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10059 7276-7281 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10060 7355-7360 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10061 7498-7503 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10062 7511-7516 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10063 3275-3284 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T10064 5176-5179 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR
T10065 7138-7141 http://purl.obolibrary.org/obo/GO_0042101 denotes TCR

sentences

Id Subject Object Predicate Lexical cue
T7964 313-562 Sentence denotes We isolated CD8+ T cells from Runx3−/− (KO) mice of the outbred ICR background and their WT Runx3+/+ littermates by positive selection with anti-CD8 magnetic beads (Figs. S1 and S2, available at http://www.jem.org/cgi/content/full/jem.20081242/DC1).
T7965 563-742 Sentence denotes Strikingly, Runx3−/− CD8+ T cells were strongly impaired in their ability to differentiate into effector CTLs, as judged by expression of perforin, granzyme B, and IFN-γ (Fig. 3).
T7966 743-894 Sentence denotes Compared with WT T cells, perforin mRNA and protein expression were essentially undetectable in Runx3−/− T cells at day 6 of culture (Fig. 3, A and B).
T7967 895-1009 Sentence denotes Runx3−/− T cells also had no detectable Eomes expression; in contrast, T-bet expression was unimpaired (Fig. 3 A).
T7968 1010-1145 Sentence denotes Furthermore, Runx3 was required for maximal production of IFN-γ, but not TNF or IL-2, by CD8+ T cells restimulated at day 6 (Fig. 3 C).
T7969 2284-2577 Sentence denotes We previously reported that Th1 cell differentiation was regulated through a feed-forward loop in which T-bet is up-regulated early and induces Runx3, after which T-bet and Runx3 cooperate to induce IFN-γ and silence IL-4, thus promoting stable differentiation toward the Th1 lineage (15, 22).
T7970 2578-3048 Sentence denotes Because (a) Runx3 appeared necessary for Eomes induction (Fig. 3 A), (b) the kinetics of Eomes expression paralleled those of perforin expression (Fig. 2), and (c) overexpression of Eo-VP16 in either WT or T-bet–deficient T cells led to an increase in both perforin and IFN-γ expression (Fig. 2, B and D), we asked whether CTL differentiation was also potentially regulated by a feed-forward loop involving these same two classes of Runx and T-box transcription factors.
T7971 3049-3241 Sentence denotes Specifically, we asked whether Runx3, which was necessary for Eomes induction, then cooperated with Eomes to regulate transcription of the effector CTL markers perforin, IFN-γ, and granzyme B.
T7972 3242-3420 Sentence denotes To test this hypothesis, we used chromatin immunoprecipitation (ChIP) assays to ask whether Eomes and Runx3 bound regulatory regions of the Prf1, Ifng, and Gzmb genes (Fig. 3 D).
T7973 3421-3498 Sentence denotes Both proteins associated with gene regulatory regions in differentiated CTLs.
T7974 3499-3897 Sentence denotes Runx3 bound to the Prf1 and Gzmb transcription start sites (TSS); to a known IL-2 responsive enhancer located near −1 kb of the Prf1 gene (23); to the distal CTL-specific DNase I hypersensitive site 9 in the Prf1 locus (24); to the Ifng promoter near the TSS, as previously reported for Th1 cells (10); and to several DNase I hypersensitive sites in the Ifng locus (Fig. 3 D and not depicted) (25).
T7975 3898-4216 Sentence denotes Eomes bound primarily to the Prf1 TSS and the −1 kb enhancer; this binding was substantially greater than that observed at the promoter of the Il2rb gene, a known direct target of Eomes (8), and comparable to that observed at the Ifng TSS, a known target of T-box proteins in both Th1 and CD8+ T cells (Fig. 3 D) (17).
T7976 4217-4403 Sentence denotes To determine whether Runx3 controlled the expression of CTL effector genes through its induction of Eomes, we retrovirally expressed Runx3 and Eo-VP16 in CD8+ T cells from Runx3−/− mice.
T7977 4404-4686 Sentence denotes Because of the limited number of CD8+ T cells in these mice, and because we saw no difference between Runx3−/− CD8+CD4− SP and CD8+CD4+ DP cells in our previous experiments, we used total Runx3−/− CD8+ T cells without further fractionation as recipients for retroviral transduction.
T7978 4687-4828 Sentence denotes Reconstitution of Runx3−/− CD8+ T cells with Runx3 restored expression of Eomes as well as perforin, granzyme B, and IFN-γ (Fig. 4, A and B).
T7979 4829-5015 Sentence denotes In addition, Runx3−/− T cells showed a compensatory up-regulation of Runx1, which was suppressed upon reconstitution with Runx3, indicating that Runx1 is a target of repression by Runx3.
T7980 5016-5212 Sentence denotes Notably, Eo-VP16 did not up-regulate perforin expression when expressed in Runx3−/− cells, even though it restored the capacity to induce IFN-γ expression upon TCR restimulation (Fig. 4, A and B).
T7981 5213-5293 Sentence denotes This result suggests strongly that perforin expression requires Runx3 and Eomes.
T7982 6965-7128 Sentence denotes As expected from their defect in perforin and granzyme B expression, Runx3−/− CD8+ T cells showed defective cytolytic activity in a mixed lymphocyte reaction (12).
T7983 7129-7257 Sentence denotes However, TCR-stimulated Runx3−/− CD8+ cells were as effective as WT cells in killing tumor cells in a redirected CTL assay (12).
T7984 7258-7399 Sentence denotes Furthermore, CD8+ cells from the peritoneal cavity of Runx3−/− mice immunized with certain tumor cells effectively killed these targets (13).
T7985 7400-7675 Sentence denotes Therefore, although activation of the perforin/granzyme B machinery is defective in Runx3−/− CD8+ cells, these cells are not entirely devoid of cytolytic activity and could still effectively kill targets, possibly by alternative mechanisms such as the Fas–Fas ligand pathway.
T20952 5304-5386 Sentence denotes Runx3 controls Eomes, perforin, granzyme B, and IFN-γ expression in effector CTLs.
T20953 5387-5569 Sentence denotes Runx3+/+ or Runx3−/− CD8+ T cells were activated and transduced with retroviruses bearing an empty IRES-GFP cassette (GFP) or also encoding Eomes-VP16 (Eo-VP16) or Myc-Runx3 (Runx3).
T20954 5570-5775 Sentence denotes The frequency of transduced cells in the cultures was equivalent for all constructs (∼75–90% GFP+ cells; not depicted). (A) Protein expression in whole-cell extracts (day 6) was analyzed by immunoblotting.
T20955 5776-6108 Sentence denotes Overexpression of Eomes-VP16 cannot be detected with the Eomes antibody, as the C-terminal epitope is within the region that has been replaced with the VP16 transactivation domain. (B) Expression of granzyme B and IFN-γ after culture for 6 d and restimulation for 4 h with PMA and ionomycin was determined by intracellular staining.
T20956 6109-6287 Sentence denotes The percentage of positively stained cells is shown above the gate; the mean fluorescence intensity (MFI) of granzyme B staining for the total population is shown below the gate.
T20957 6288-6347 Sentence denotes The vertical gray lines indicate the MFI for WT GFP+ cells.
T20958 6348-6503 Sentence denotes Results are representative of at least two independent experiments. (C) Schematic diagram of the transcriptional network involving Runx3 and T-box factors.
T20959 6504-6580 Sentence denotes T-bet is induced by TCR signals and is essential for early IFN-γ expression.
T20960 6581-6702 Sentence denotes Runx3 is present in naive CD8+ T cells and represses Runx1 and induces Eomes, perforin, granzyme B, and IFN-γ expression.
T20961 6703-6848 Sentence denotes Eomes may participate in sustaining late IFN-γ expression, whereas Runx3 and Eomes (but not T-bet) may cooperate to activate perforin expression.
T20962 6849-6965 Sentence denotes The dotted line indicates the partial effect of T-bet deficiency on Gzmb mRNA but not granzyme B protein expression.
T20175 1156-1687 Sentence denotes Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3−/− CD8+ SP T cells differentiated for 6 d. β-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3−/− CD8+ T cells differentiated for 6 d. β–Actin was used as a loading control. (C) Expression of granzyme B, IFN-γ, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3−/− CD8+ SP T cells differentiated for 6 d.
T20176 1688-1758 Sentence denotes The vertical gray line indicates the granzyme B MFI for WT GFP+ cells.
T20177 1759-1902 Sentence denotes Results in A–C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus.
T20178 1903-2029 Sentence denotes Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin.
T20179 2030-2161 Sentence denotes The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations.
T20180 2162-2284 Sentence denotes The efficiency of recovery of input for the −1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.
T7962 0-102 Sentence denotes Runx3 controls multiple aspects of the CTL differentiation program, in part through induction of Eomes
T7963 103-312 Sentence denotes Because Runx3 is highly expressed in peripheral CD8+ T cells, and because of the T-bet-Runx3 cooperation we observed earlier in CD4+ T cells (15), we examined the role of Runx3 in effector CTL differentiation.
T84 0-102 Sentence denotes Runx3 controls multiple aspects of the CTL differentiation program, in part through induction of Eomes
T85 103-312 Sentence denotes Because Runx3 is highly expressed in peripheral CD8+ T cells, and because of the T-bet-Runx3 cooperation we observed earlier in CD4+ T cells (15), we examined the role of Runx3 in effector CTL differentiation.
T86 313-483 Sentence denotes We isolated CD8+ T cells from Runx3−/− (KO) mice of the outbred ICR background and their WT Runx3+/+ littermates by positive selection with anti-CD8 magnetic beads (Figs.
T87 484-562 Sentence denotes S1 and S2, available at http://www.jem.org/cgi/content/full/jem.20081242/DC1).
T88 563-742 Sentence denotes Strikingly, Runx3−/− CD8+ T cells were strongly impaired in their ability to differentiate into effector CTLs, as judged by expression of perforin, granzyme B, and IFN-γ (Fig. 3).
T89 743-894 Sentence denotes Compared with WT T cells, perforin mRNA and protein expression were essentially undetectable in Runx3−/− T cells at day 6 of culture (Fig. 3, A and B).
T90 895-1009 Sentence denotes Runx3−/− T cells also had no detectable Eomes expression; in contrast, T-bet expression was unimpaired (Fig. 3 A).
T91 1010-1145 Sentence denotes Furthermore, Runx3 was required for maximal production of IFN-γ, but not TNF or IL-2, by CD8+ T cells restimulated at day 6 (Fig. 3 C).
T92 1146-1155 Sentence denotes Figure 3.
T93 1156-1687 Sentence denotes Key role for Runx3 in effector CTL differentiation. (A) Western analysis of Runx3, Eomes, T-bet, and perforin expression in Runx3+/+ versus Runx3−/− CD8+ SP T cells differentiated for 6 d. β-Actin was used as a loading control. (B) Northern blot analysis of Prf1 mRNA expression in Runx3+/+ versus Runx3−/− CD8+ T cells differentiated for 6 d. β–Actin was used as a loading control. (C) Expression of granzyme B, IFN-γ, TNF, and IL-2 by resting or restimulated (6 h) Runx3+/+ versus Runx3−/− CD8+ SP T cells differentiated for 6 d.
T94 1688-1758 Sentence denotes The vertical gray line indicates the granzyme B MFI for WT GFP+ cells.
T95 1759-1902 Sentence denotes Results in A–C are representative of two independent experiments. (D) ChIP analysis of binding of endogenous Runx3 and Eomes to the Prf1 locus.
T96 1903-2029 Sentence denotes Enrichment of the indicated genomic regions was evaluated by real-time PCR of DNA from immunoprecipitated and input chromatin.
T97 2030-2161 Sentence denotes The data are the means of duplicate measurements from two chromatin preparations from two independent CD8+ T cell differentiations.
T98 2162-2577 Sentence denotes The efficiency of recovery of input for the −1-kb region of Prf1 was 0.97% for the Runx3 ChIP and 0.5% for the Eomes ChIP.We previously reported that Th1 cell differentiation was regulated through a feed-forward loop in which T-bet is up-regulated early and induces Runx3, after which T-bet and Runx3 cooperate to induce IFN-γ and silence IL-4, thus promoting stable differentiation toward the Th1 lineage (15, 22).
T99 2578-3048 Sentence denotes Because (a) Runx3 appeared necessary for Eomes induction (Fig. 3 A), (b) the kinetics of Eomes expression paralleled those of perforin expression (Fig. 2), and (c) overexpression of Eo-VP16 in either WT or T-bet–deficient T cells led to an increase in both perforin and IFN-γ expression (Fig. 2, B and D), we asked whether CTL differentiation was also potentially regulated by a feed-forward loop involving these same two classes of Runx and T-box transcription factors.
T100 3049-3241 Sentence denotes Specifically, we asked whether Runx3, which was necessary for Eomes induction, then cooperated with Eomes to regulate transcription of the effector CTL markers perforin, IFN-γ, and granzyme B.
T101 3242-3420 Sentence denotes To test this hypothesis, we used chromatin immunoprecipitation (ChIP) assays to ask whether Eomes and Runx3 bound regulatory regions of the Prf1, Ifng, and Gzmb genes (Fig. 3 D).
T102 3421-3498 Sentence denotes Both proteins associated with gene regulatory regions in differentiated CTLs.
T103 3499-3897 Sentence denotes Runx3 bound to the Prf1 and Gzmb transcription start sites (TSS); to a known IL-2 responsive enhancer located near −1 kb of the Prf1 gene (23); to the distal CTL-specific DNase I hypersensitive site 9 in the Prf1 locus (24); to the Ifng promoter near the TSS, as previously reported for Th1 cells (10); and to several DNase I hypersensitive sites in the Ifng locus (Fig. 3 D and not depicted) (25).
T104 3898-4216 Sentence denotes Eomes bound primarily to the Prf1 TSS and the −1 kb enhancer; this binding was substantially greater than that observed at the promoter of the Il2rb gene, a known direct target of Eomes (8), and comparable to that observed at the Ifng TSS, a known target of T-box proteins in both Th1 and CD8+ T cells (Fig. 3 D) (17).
T105 4217-4403 Sentence denotes To determine whether Runx3 controlled the expression of CTL effector genes through its induction of Eomes, we retrovirally expressed Runx3 and Eo-VP16 in CD8+ T cells from Runx3−/− mice.
T106 4404-4686 Sentence denotes Because of the limited number of CD8+ T cells in these mice, and because we saw no difference between Runx3−/− CD8+CD4− SP and CD8+CD4+ DP cells in our previous experiments, we used total Runx3−/− CD8+ T cells without further fractionation as recipients for retroviral transduction.
T107 4687-4828 Sentence denotes Reconstitution of Runx3−/− CD8+ T cells with Runx3 restored expression of Eomes as well as perforin, granzyme B, and IFN-γ (Fig. 4, A and B).
T108 4829-5015 Sentence denotes In addition, Runx3−/− T cells showed a compensatory up-regulation of Runx1, which was suppressed upon reconstitution with Runx3, indicating that Runx1 is a target of repression by Runx3.
T109 5016-5212 Sentence denotes Notably, Eo-VP16 did not up-regulate perforin expression when expressed in Runx3−/− cells, even though it restored the capacity to induce IFN-γ expression upon TCR restimulation (Fig. 4, A and B).
T110 5213-5293 Sentence denotes This result suggests strongly that perforin expression requires Runx3 and Eomes.
T111 5294-5303 Sentence denotes Figure 4.
T112 5304-5386 Sentence denotes Runx3 controls Eomes, perforin, granzyme B, and IFN-γ expression in effector CTLs.
T113 5387-5569 Sentence denotes Runx3+/+ or Runx3−/− CD8+ T cells were activated and transduced with retroviruses bearing an empty IRES-GFP cassette (GFP) or also encoding Eomes-VP16 (Eo-VP16) or Myc-Runx3 (Runx3).
T114 5570-5775 Sentence denotes The frequency of transduced cells in the cultures was equivalent for all constructs (∼75–90% GFP+ cells; not depicted). (A) Protein expression in whole-cell extracts (day 6) was analyzed by immunoblotting.
T115 5776-6108 Sentence denotes Overexpression of Eomes-VP16 cannot be detected with the Eomes antibody, as the C-terminal epitope is within the region that has been replaced with the VP16 transactivation domain. (B) Expression of granzyme B and IFN-γ after culture for 6 d and restimulation for 4 h with PMA and ionomycin was determined by intracellular staining.
T116 6109-6287 Sentence denotes The percentage of positively stained cells is shown above the gate; the mean fluorescence intensity (MFI) of granzyme B staining for the total population is shown below the gate.
T117 6288-6347 Sentence denotes The vertical gray lines indicate the MFI for WT GFP+ cells.
T118 6348-6503 Sentence denotes Results are representative of at least two independent experiments. (C) Schematic diagram of the transcriptional network involving Runx3 and T-box factors.
T119 6504-6580 Sentence denotes T-bet is induced by TCR signals and is essential for early IFN-γ expression.
T120 6581-6702 Sentence denotes Runx3 is present in naive CD8+ T cells and represses Runx1 and induces Eomes, perforin, granzyme B, and IFN-γ expression.
T121 6703-6848 Sentence denotes Eomes may participate in sustaining late IFN-γ expression, whereas Runx3 and Eomes (but not T-bet) may cooperate to activate perforin expression.
T122 6849-7128 Sentence denotes The dotted line indicates the partial effect of T-bet deficiency on Gzmb mRNA but not granzyme B protein expression.As expected from their defect in perforin and granzyme B expression, Runx3−/− CD8+ T cells showed defective cytolytic activity in a mixed lymphocyte reaction (12).
T123 7129-7257 Sentence denotes However, TCR-stimulated Runx3−/− CD8+ cells were as effective as WT cells in killing tumor cells in a redirected CTL assay (12).
T124 7258-7399 Sentence denotes Furthermore, CD8+ cells from the peritoneal cavity of Runx3−/− mice immunized with certain tumor cells effectively killed these targets (13).
T125 7400-7675 Sentence denotes Therefore, although activation of the perforin/granzyme B machinery is defective in Runx3−/− CD8+ cells, these cells are not entirely devoid of cytolytic activity and could still effectively kill targets, possibly by alternative mechanisms such as the Fas–Fas ligand pathway.

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T11027 0-5 Protein denotes Runx3
T11028 84-93 Positive_regulation denotes induction
T11029 97-102 Protein denotes Eomes
T11030 111-116 Protein denotes Runx3
T11031 127-136 Gene_expression denotes expressed
T11032 151-154 Protein denotes CD8
T11033 184-189 Protein denotes T-bet
T11034 190-195 Protein denotes Runx3
T11035 231-234 Protein denotes CD4
T11036 274-279 Protein denotes Runx3
T11037 325-328 Protein denotes CD8
T11038 343-348 Protein denotes Runx3
T11039 405-410 Protein denotes Runx3
T11040 458-461 Protein denotes CD8
T11041 575-580 Protein denotes Runx3
T11042 584-587 Protein denotes CD8
T11043 687-697 Gene_expression denotes expression true
T11044 687-697 Gene_expression denotes expression true
T11045 687-697 Gene_expression denotes expression true
T11046 701-709 Protein denotes perforin
T11047 711-721 Protein denotes granzyme B
T11048 727-732 Protein denotes IFN-γ
T11049 769-777 Protein denotes perforin
T11050 795-805 Gene_expression denotes expression
T11051 823-835 Positive_regulation denotes undetectable true
T11052 839-844 Protein denotes Runx3
T11053 895-900 Protein denotes Runx3
T11054 935-940 Protein denotes Eomes
T11055 941-951 Gene_expression denotes expression true
T11056 966-971 Protein denotes T-bet
T11057 972-982 Gene_expression denotes expression
T11058 987-997 Negative_regulation denotes unimpaired true
T11059 1023-1028 Protein denotes Runx3
T11060 1033-1041 Positive_regulation denotes required
T11061 1033-1041 Positive_regulation denotes required
T11062 1033-1041 Positive_regulation denotes required
T11063 1054-1064 Gene_expression denotes production
T11064 1054-1064 Gene_expression denotes production
T11065 1054-1064 Gene_expression denotes production
T11066 1068-1073 Protein denotes IFN-γ
T11067 1083-1086 Protein denotes TNF
T11068 1090-1094 Protein denotes IL-2
T11069 1099-1102 Protein denotes CD8
T11070 2388-2393 Protein denotes T-bet
T11071 2397-2409 Positive_regulation denotes up-regulated
T11072 2420-2427 Positive_regulation denotes induces
T11073 2428-2433 Protein denotes Runx3
T11074 2447-2452 Protein denotes T-bet
T11075 2457-2462 Protein denotes Runx3
T11076 2476-2482 Positive_regulation denotes induce
T11077 2476-2482 Positive_regulation denotes induce
T11078 2483-2488 Protein denotes IFN-γ
T11079 2493-2500 Negative_regulation denotes silence
T11080 2493-2500 Negative_regulation denotes silence
T11081 2501-2505 Protein denotes IL-4
T11082 2590-2595 Protein denotes Runx3
T11083 2605-2614 Positive_regulation denotes necessary true
T11084 2619-2624 Protein denotes Eomes
T11085 2625-2634 Positive_regulation denotes induction
T11086 2667-2672 Protein denotes Eomes
T11087 2673-2683 Gene_expression denotes expression
T11088 2704-2712 Protein denotes perforin
T11089 2713-2723 Gene_expression denotes expression
T11090 2742-2756 Positive_regulation denotes overexpression
T11091 2760-2767 Protein denotes Eo-VP16
T11092 2784-2789 Protein denotes T-bet
T11093 2790-2799 Negative_regulation denotes deficient
T11094 2808-2811 Positive_regulation denotes led
T11095 2808-2811 Positive_regulation denotes led
T11096 2818-2826 Positive_regulation denotes increase
T11097 2818-2826 Positive_regulation denotes increase
T11098 2835-2843 Protein denotes perforin
T11099 2848-2853 Protein denotes IFN-γ
T11100 2854-2864 Gene_expression denotes expression
T11101 2854-2864 Gene_expression denotes expression
T11102 3080-3085 Protein denotes Runx3
T11103 3097-3106 Positive_regulation denotes necessary true
T11104 3111-3116 Protein denotes Eomes
T11105 3117-3126 Positive_regulation denotes induction
T11106 3149-3154 Protein denotes Eomes
T11107 3158-3166 Regulation denotes regulate
T11108 3158-3166 Regulation denotes regulate
T11109 3158-3166 Regulation denotes regulate
T11110 3158-3166 Regulation denotes regulate
T11111 3158-3166 Regulation denotes regulate
T11112 3158-3166 Regulation denotes regulate
T11113 3167-3180 Transcription denotes transcription
T11114 3167-3180 Transcription denotes transcription
T11115 3167-3180 Transcription denotes transcription
T11116 3209-3217 Protein denotes perforin
T11117 3219-3224 Protein denotes IFN-γ
T11118 3230-3240 Protein denotes granzyme B
T11119 3334-3339 Protein denotes Eomes
T11120 3344-3349 Protein denotes Runx3
T11121 3350-3355 Binding denotes bound true
T11122 3350-3355 Binding denotes bound true
T11123 3350-3355 Binding denotes bound true
T11124 3350-3355 Binding denotes bound true
T11125 3350-3355 Binding denotes bound true
T11126 3350-3355 Binding denotes bound true
T11127 3356-3374 Entity denotes regulatory regions
T11128 3382-3386 Protein denotes Prf1
T11129 3388-3392 Protein denotes Ifng
T11130 3398-3402 Protein denotes Gzmb
T11131 3435-3445 Binding denotes associated
T11132 3435-3445 Binding denotes associated
T11133 3499-3504 Protein denotes Runx3
T11134 3505-3510 Binding denotes bound
T11135 3505-3510 Binding denotes bound
T11136 3518-3522 Protein denotes Prf1
T11137 3527-3531 Protein denotes Gzmb
T11138 3532-3557 Entity denotes transcription start sites
T11139 3627-3631 Protein denotes Prf1
T11140 3707-3711 Protein denotes Prf1
T11141 3731-3735 Protein denotes Ifng
T11142 3853-3857 Protein denotes Ifng
T11143 3898-3903 Protein denotes Eomes
T11144 3904-3909 Binding denotes bound
T11145 3904-3909 Binding denotes bound
T11146 3927-3931 Protein denotes Prf1
T11147 3932-3935 Entity denotes TSS
T11148 3944-3958 Entity denotes −1 kb enhancer
T11149 4004-4008 Binding denotes that
T11150 4025-4033 Entity denotes promoter
T11151 4041-4046 Protein denotes Il2rb
T11152 4068-4074 Binding denotes target
T11153 4078-4083 Protein denotes Eomes
T11154 4107-4111 Binding denotes that
T11155 4128-4132 Protein denotes Ifng
T11156 4133-4136 Entity denotes TSS
T11157 4146-4152 Binding denotes target
T11158 4187-4190 Protein denotes CD8
T11159 4238-4243 Protein denotes Runx3
T11160 4304-4313 Positive_regulation denotes induction
T11161 4317-4322 Protein denotes Eomes
T11162 4340-4349 Gene_expression denotes expressed
T11163 4340-4349 Gene_expression denotes expressed
T11164 4350-4355 Protein denotes Runx3
T11165 4360-4367 Protein denotes Eo-VP16
T11166 4371-4374 Protein denotes CD8
T11167 4389-4394 Protein denotes Runx3
T11168 4437-4440 Protein denotes CD8
T11169 4506-4511 Protein denotes Runx3
T11170 4515-4518 Protein denotes CD8
T11171 4519-4522 Protein denotes CD4
T11172 4531-4534 Protein denotes CD8
T11173 4535-4538 Protein denotes CD4
T11174 4592-4597 Protein denotes Runx3
T11175 4601-4604 Protein denotes CD8
T11176 4705-4710 Protein denotes Runx3
T11177 4714-4717 Protein denotes CD8
T11178 4732-4737 Protein denotes Runx3
T11179 4738-4746 Positive_regulation denotes restored
T11180 4738-4746 Positive_regulation denotes restored
T11181 4738-4746 Positive_regulation denotes restored
T11182 4738-4746 Positive_regulation denotes restored
T11183 4747-4757 Gene_expression denotes expression
T11184 4747-4757 Gene_expression denotes expression
T11185 4747-4757 Gene_expression denotes expression
T11186 4747-4757 Gene_expression denotes expression
T11187 4761-4766 Protein denotes Eomes
T11188 4778-4786 Protein denotes perforin
T11189 4788-4798 Protein denotes granzyme B
T11190 4804-4809 Protein denotes IFN-γ
T11191 4842-4847 Protein denotes Runx3
T11192 4881-4894 Positive_regulation denotes up-regulation
T11193 4898-4903 Protein denotes Runx1
T11194 4915-4925 Negative_regulation denotes suppressed
T11195 4951-4956 Protein denotes Runx3
T11196 4974-4979 Protein denotes Runx1
T11197 4995-5005 Negative_regulation denotes repression
T11198 5009-5014 Protein denotes Runx3
T11199 5025-5032 Protein denotes Eo-VP16
T11200 5041-5052 Positive_regulation denotes up-regulate true
T11201 5053-5061 Protein denotes perforin
T11202 5062-5072 Gene_expression denotes expression
T11203 5078-5087 Gene_expression denotes expressed
T11204 5091-5096 Protein denotes Runx3
T11205 5122-5130 Positive_regulation denotes restored
T11206 5147-5153 Positive_regulation denotes induce
T11207 5154-5159 Protein denotes IFN-γ
T11208 5160-5170 Gene_expression denotes expression
T11209 5248-5256 Protein denotes perforin
T11210 5257-5267 Gene_expression denotes expression
T11211 5268-5276 Positive_regulation denotes requires true
T11212 5268-5276 Positive_regulation denotes requires true
T11213 5277-5282 Protein denotes Runx3
T11214 5287-5292 Protein denotes Eomes
T11215 6988-6994 Positive_regulation denotes defect true
T11216 6988-6994 Positive_regulation denotes defect true
T11217 6988-6994 Positive_regulation denotes defect true
T11218 6988-6994 Positive_regulation denotes defect true
T11219 6998-7006 Protein denotes perforin
T11220 7011-7021 Protein denotes granzyme B
T11221 7022-7032 Gene_expression denotes expression
T11222 7022-7032 Gene_expression denotes expression
T11223 7034-7039 Protein denotes Runx3
T11224 7043-7046 Protein denotes CD8
T11225 7153-7158 Protein denotes Runx3
T11226 7162-7165 Protein denotes CD8
T11227 7271-7274 Protein denotes CD8
T11228 7312-7317 Protein denotes Runx3
T11229 7420-7430 Positive_regulation denotes activation
T11230 7420-7430 Positive_regulation denotes activation
T11231 7438-7446 Protein denotes perforin
T11232 7447-7457 Protein denotes granzyme B
T11233 7471-7480 Negative_regulation denotes defective
T11234 7471-7480 Negative_regulation denotes defective
T11235 7484-7489 Protein denotes Runx3
T11236 7493-7496 Protein denotes CD8
T11237 7652-7655 Protein denotes Fas
T11238 7656-7666 Protein denotes Fas ligand
T20666 1169-1174 Protein denotes Runx3
T20667 1232-1237 Protein denotes Runx3
T20668 1239-1244 Protein denotes Eomes
T20669 1246-1251 Protein denotes T-bet
T20670 1257-1265 Protein denotes perforin
T20671 1266-1276 Gene_expression denotes expression true
T20672 1266-1276 Gene_expression denotes expression true
T20673 1266-1276 Gene_expression denotes expression true
T20674 1266-1276 Gene_expression denotes expression true
T20675 1280-1285 Protein denotes Runx3
T20676 1296-1301 Protein denotes Runx3
T20677 1305-1308 Protein denotes CD8
T20678 1345-1352 Protein denotes β-Actin
T20679 1414-1418 Protein denotes Prf1
T20680 1419-1434 Transcription denotes mRNA expression true
T20681 1438-1443 Protein denotes Runx3
T20682 1454-1459 Protein denotes Runx3
T20683 1463-1466 Protein denotes CD8
T20684 1500-1507 Protein denotes β–Actin
T20685 1543-1553 Gene_expression denotes Expression true
T20686 1543-1553 Gene_expression denotes Expression true
T20687 1543-1553 Gene_expression denotes Expression true
T20688 1543-1553 Gene_expression denotes Expression true
T20689 1557-1567 Protein denotes granzyme B
T20690 1569-1574 Protein denotes IFN-γ
T20691 1576-1579 Protein denotes TNF
T20692 1585-1589 Protein denotes IL-2
T20693 1623-1628 Protein denotes Runx3
T20694 1639-1644 Protein denotes Runx3
T20695 1648-1651 Protein denotes CD8
T20696 1725-1735 Protein denotes granzyme B
T20697 1747-1750 Protein denotes GFP
T20698 1846-1853 Binding denotes binding true
T20699 1846-1853 Binding denotes binding true
T20700 1868-1873 Protein denotes Runx3
T20701 1878-1883 Protein denotes Eomes
T20702 1891-1895 Protein denotes Prf1
T20703 2132-2135 Protein denotes CD8
T20704 2222-2226 Protein denotes Prf1
T20705 2245-2250 Protein denotes Runx3
T20706 2273-2278 Protein denotes Eomes
T21972 5304-5309 Protein denotes Runx3
T21973 5310-5318 Regulation denotes controls
T21974 5310-5318 Regulation denotes controls
T21975 5310-5318 Regulation denotes controls
T21976 5310-5318 Regulation denotes controls
T21977 5319-5324 Protein denotes Eomes
T21978 5326-5334 Protein denotes perforin
T21979 5336-5346 Protein denotes granzyme B
T21980 5352-5357 Protein denotes IFN-γ
T21981 5358-5368 Gene_expression denotes expression
T21982 5358-5368 Gene_expression denotes expression
T21983 5358-5368 Gene_expression denotes expression
T21984 5358-5368 Gene_expression denotes expression
T21985 5387-5392 Protein denotes Runx3
T21986 5399-5404 Protein denotes Runx3
T21987 5408-5411 Protein denotes CD8
T21988 5491-5494 Protein denotes GFP
T21989 5527-5537 Protein denotes Eomes-VP16
T21990 5539-5546 Protein denotes Eo-VP16
T21991 5551-5554 Protein denotes Myc
T21992 5555-5560 Protein denotes Runx3
T21993 5562-5567 Protein denotes Runx3
T21994 5776-5790 Positive_regulation denotes Overexpression
T21995 5794-5804 Protein denotes Eomes-VP16
T21996 5833-5838 Protein denotes Eomes
T21997 5928-5932 Protein denotes VP16
T21998 5961-5971 Gene_expression denotes Expression true
T21999 5961-5971 Gene_expression denotes Expression true
T22000 5975-5985 Protein denotes granzyme B
T22001 5990-5995 Protein denotes IFN-γ
T22002 6218-6228 Protein denotes granzyme B
T22003 6229-6237 Gene_expression denotes staining true
T22004 6336-6339 Protein denotes GFP
T22005 6479-6484 Protein denotes Runx3
T22006 6504-6509 Protein denotes T-bet
T22007 6513-6520 Positive_regulation denotes induced
T22008 6543-6552 Positive_regulation denotes essential
T22009 6563-6568 Protein denotes IFN-γ
T22010 6569-6579 Gene_expression denotes expression
T22011 6581-6586 Protein denotes Runx3
T22012 6590-6597 Gene_expression denotes present
T22013 6607-6610 Protein denotes CD8
T22014 6624-6633 Negative_regulation denotes represses
T22015 6634-6639 Protein denotes Runx1
T22016 6644-6651 Positive_regulation denotes induces
T22017 6644-6651 Positive_regulation denotes induces
T22018 6644-6651 Positive_regulation denotes induces
T22019 6644-6651 Positive_regulation denotes induces
T22020 6652-6657 Protein denotes Eomes
T22021 6659-6667 Protein denotes perforin
T22022 6669-6679 Protein denotes granzyme B
T22023 6685-6690 Protein denotes IFN-γ
T22024 6691-6701 Gene_expression denotes expression
T22025 6691-6701 Gene_expression denotes expression
T22026 6691-6701 Gene_expression denotes expression
T22027 6691-6701 Gene_expression denotes expression
T22028 6703-6708 Protein denotes Eomes
T22029 6713-6724 Regulation denotes participate true
T22030 6744-6749 Protein denotes IFN-γ
T22031 6750-6760 Gene_expression denotes expression
T22032 6770-6775 Protein denotes Runx3
T22033 6780-6785 Protein denotes Eomes
T22034 6795-6800 Protein denotes T-bet
T22035 6819-6827 Positive_regulation denotes activate true
T22036 6819-6827 Positive_regulation denotes activate true
T22037 6819-6827 Positive_regulation denotes activate true true
T22038 6828-6836 Protein denotes perforin
T22039 6837-6847 Gene_expression denotes expression
T22040 6887-6893 Regulation denotes effect
T22041 6887-6893 Regulation denotes effect
T22042 6897-6902 Protein denotes T-bet
T22043 6903-6913 Negative_regulation denotes deficiency
T22044 6917-6921 Protein denotes Gzmb
T22045 6935-6945 Protein denotes granzyme B
T22046 6954-6964 Gene_expression denotes expression
T22047 6954-6964 Gene_expression denotes expression true
R8676 T11027 T11028 causeOf Runx3,induction
R8679 T11029 T11028 themeOf Eomes,induction
R8680 T11030 T11031 themeOf Runx3,expressed
R8684 T11133 T11135 themeOf Runx3,bound
R8685 T11046 T11043 themeOf perforin,expression
R8686 T11133 T11134 themeOf Runx3,bound
R8687 T11138 T11135 themeOf transcription start sites,bound
R8688 T11047 T11045 themeOf granzyme B,expression
R8689 T11048 T11044 themeOf IFN-γ,expression
R8690 T11049 T11050 themeOf perforin,expression
R8691 T11050 T11051 themeOf expression,undetectable
R8692 T11138 T11136 partOf transcription start sites,Prf1
R8693 T11054 T11055 themeOf Eomes,expression
R8694 T11056 T11057 themeOf T-bet,expression
R8695 T11057 T11058 themeOf expression,unimpaired
R8696 T11138 T11134 themeOf transcription start sites,bound
R8697 T11138 T11137 partOf transcription start sites,Gzmb
R8698 T11059 T11061 causeOf Runx3,required
R8699 T11059 T11060 causeOf Runx3,required
R8700 T11059 T11062 causeOf Runx3,required
R8701 T11143 T11149 themeOf Eomes,that
R8702 T11063 T11062 themeOf production,required
R8703 T11064 T11060 themeOf production,required
R8704 T11065 T11061 themeOf production,required
R8705 T11066 T11065 themeOf IFN-γ,production
R8706 T11067 T11064 themeOf TNF,production
R8707 T11068 T11063 themeOf IL-2,production
R8708 T11143 T11154 themeOf Eomes,that
R8709 T11070 T11071 themeOf T-bet,up-regulated
R8710 T11143 T11145 themeOf Eomes,bound
R8711 T11143 T11144 themeOf Eomes,bound
R8712 T11073 T11072 themeOf Runx3,induces
R8713 T11147 T11145 themeOf TSS,bound
R8714 T11074 T11077 causeOf T-bet,induce
R8715 T11074 T11080 causeOf T-bet,silence
R8716 T11075 T11076 causeOf Runx3,induce
R8717 T11075 T11079 causeOf Runx3,silence
R8718 T11078 T11077 themeOf IFN-γ,induce
R8719 T11078 T11076 themeOf IFN-γ,induce
R8720 T11081 T11080 themeOf IL-4,silence
R8721 T11081 T11079 themeOf IL-4,silence
R8722 T11147 T11146 partOf TSS,Prf1
R8723 T11082 T11083 causeOf Runx3,necessary
R8724 T11148 T11144 themeOf −1 kb enhancer,bound
R8725 T11084 T11085 themeOf Eomes,induction
R8726 T11085 T11083 themeOf induction,necessary
R8727 T11148 T11146 partOf −1 kb enhancer,Prf1
R8728 T11086 T11087 themeOf Eomes,expression
R8729 T11150 T11149 themeOf promoter,that
R8730 T11088 T11089 themeOf perforin,expression
R8731 T11090 T11094 causeOf overexpression,led
R8732 T11150 T11151 partOf promoter,Il2rb
R8733 T11090 T11095 causeOf overexpression,led
R8734 T11150 T11152 themeOf promoter,target
R8735 T11091 T11090 themeOf Eo-VP16,overexpression
R8736 T11092 T11093 themeOf T-bet,deficient
R8737 T11153 T11152 themeOf Eomes,target
R8738 T11096 T11094 themeOf increase,led
R8739 T11156 T11154 themeOf TSS,that
R8740 T11097 T11095 themeOf increase,led
R8741 T11098 T11101 themeOf perforin,expression
R8742 T11099 T11100 themeOf IFN-γ,expression
R8743 T11100 T11097 themeOf expression,increase
R8744 T11101 T11096 themeOf expression,increase
R8745 T11156 T11155 partOf TSS,Ifng
R8746 T11102 T11103 causeOf Runx3,necessary
R8747 T11102 T11110 causeOf Runx3,regulate
R8748 T11102 T11108 causeOf Runx3,regulate
R8749 T11102 T11112 causeOf Runx3,regulate
R8750 T11104 T11105 themeOf Eomes,induction
R8751 T11105 T11103 themeOf induction,necessary
R8752 T11156 T11157 themeOf TSS,target
R8753 T11106 T11109 causeOf Eomes,regulate
R8754 T11106 T11111 causeOf Eomes,regulate
R8755 T11106 T11107 causeOf Eomes,regulate
R8756 T11159 T11160 causeOf Runx3,induction
R8757 T11161 T11160 themeOf Eomes,induction
R8758 T11113 T11112 themeOf transcription,regulate
R8759 T11113 T11107 themeOf transcription,regulate
R8760 T11114 T11108 themeOf transcription,regulate
R8761 T11114 T11111 themeOf transcription,regulate
R8762 T11115 T11110 themeOf transcription,regulate
R8763 T11115 T11109 themeOf transcription,regulate
R8764 T11116 T11115 themeOf perforin,transcription
R8765 T11164 T11163 themeOf Runx3,expressed
R8766 T11117 T11114 themeOf IFN-γ,transcription
R8767 T11118 T11113 themeOf granzyme B,transcription
R8768 T11119 T11123 themeOf Eomes,bound
R8769 T11119 T11126 themeOf Eomes,bound
R8770 T11119 T11124 themeOf Eomes,bound
R8771 T11119 T11131 themeOf Eomes,associated
R8772 T11120 T11122 themeOf Runx3,bound
R8773 T11120 T11125 themeOf Runx3,bound
R8774 T11120 T11121 themeOf Runx3,bound
R8775 T11120 T11132 themeOf Runx3,associated
R8776 T11165 T11162 themeOf Eo-VP16,expressed
R8777 T11178 T11182 causeOf Runx3,restored
R8778 T11127 T11123 themeOf regulatory regions,bound
R8779 T11127 T11128 partOf regulatory regions,Prf1
R8780 T11127 T11126 themeOf regulatory regions,bound
R8781 T11127 T11129 partOf regulatory regions,Ifng
R8782 T11127 T11124 themeOf regulatory regions,bound
R8783 T11127 T11130 partOf regulatory regions,Gzmb
R8784 T11127 T11122 themeOf regulatory regions,bound
R8785 T11127 T11125 themeOf regulatory regions,bound
R8786 T11127 T11121 themeOf regulatory regions,bound
R8787 T11178 T11181 causeOf Runx3,restored
R8788 T11178 T11180 causeOf Runx3,restored
R8789 T11178 T11179 causeOf Runx3,restored
R8790 T11183 T11181 themeOf expression,restored
R8791 T11184 T11182 themeOf expression,restored
R8792 T11185 T11180 themeOf expression,restored
R8793 T11186 T11179 themeOf expression,restored
R8794 T11187 T11184 themeOf Eomes,expression
R8795 T11188 T11183 themeOf perforin,expression
R8796 T11189 T11185 themeOf granzyme B,expression
R8798 T11190 T11186 themeOf IFN-γ,expression
R8799 T11193 T11192 themeOf Runx1,up-regulation
R8800 T11193 T11194 themeOf Runx1,suppressed
R8801 T11195 T11194 causeOf Runx3,suppressed
R8803 T11196 T11197 themeOf Runx1,repression
R8807 T11198 T11197 causeOf Runx3,repression
R8808 T11199 T11200 causeOf Eo-VP16,up-regulate
R8811 T11199 T11203 themeOf Eo-VP16,expressed
R8813 T11199 T11205 causeOf Eo-VP16,restored
R8814 T11201 T11202 themeOf perforin,expression
R8815 T11202 T11200 themeOf expression,up-regulate
R8816 T11206 T11205 themeOf induce,restored
R8825 T11207 T11208 themeOf IFN-γ,expression
R8827 T11208 T11206 themeOf expression,induce
R8829 T11209 T11210 themeOf perforin,expression
R8830 T11210 T11211 themeOf expression,requires
R8831 T11210 T11212 themeOf expression,requires
R8832 T11213 T11211 causeOf Runx3,requires
R8838 T11213 T11216 causeOf Runx3,defect
R8839 T11213 T11217 causeOf Runx3,defect
R8840 T11214 T11212 causeOf Eomes,requires
R8841 T11214 T11218 causeOf Eomes,defect
R8842 T11214 T11215 causeOf Eomes,defect
R8844 T11219 T11222 themeOf perforin,expression
R8853 T11220 T11221 themeOf granzyme B,expression
R8854 T11221 T11217 themeOf expression,defect
R8859 T11221 T11215 themeOf expression,defect
R8861 T11222 T11216 themeOf expression,defect
R8865 T11222 T11218 themeOf expression,defect
R8867 T11229 T11233 themeOf activation,defective
R8890 T11230 T11234 themeOf activation,defective
R8892 T11231 T11230 themeOf perforin,activation
R8893 T11232 T11229 themeOf granzyme B,activation
R15854 T20667 T20673 themeOf Runx3,expression
R15855 T20668 T20674 themeOf Eomes,expression
R15856 T20669 T20671 themeOf T-bet,expression
R15857 T20670 T20672 themeOf perforin,expression
R15858 T20679 T20680 themeOf Prf1,mRNA expression
R15859 T20689 T20685 themeOf granzyme B,Expression
R15860 T20690 T20686 themeOf IFN-γ,Expression
R15861 T20691 T20688 themeOf TNF,Expression
R15862 T20692 T20687 themeOf IL-2,Expression
R15863 T20700 T20699 themeOf Runx3,binding
R15864 T20701 T20698 themeOf Eomes,binding
R15865 T20702 T20699 themeOf Prf1,binding
R15866 T20702 T20698 themeOf Prf1,binding
R16849 T21972 T21976 causeOf Runx3,controls
R16850 T21972 T21975 causeOf Runx3,controls
R16851 T21972 T21974 causeOf Runx3,controls
R16852 T21972 T21973 causeOf Runx3,controls
R16853 T21977 T21982 themeOf Eomes,expression
R16854 T21978 T21983 themeOf perforin,expression
R16855 T21979 T21981 themeOf granzyme B,expression
R16856 T21980 T21984 themeOf IFN-γ,expression
R16857 T21981 T21973 themeOf expression,controls
R16858 T21982 T21975 themeOf expression,controls
R16859 T21983 T21974 themeOf expression,controls
R16860 T21984 T21976 themeOf expression,controls
R16861 T21990 T21989 equivalentTo Eo-VP16,Eomes-VP16
R16862 T21995 T21994 themeOf Eomes-VP16,Overexpression
R16863 T22000 T21999 themeOf granzyme B,Expression
R16864 T22001 T21998 themeOf IFN-γ,Expression
R16865 T22002 T22003 themeOf granzyme B,staining
R16866 T22006 T22007 themeOf T-bet,induced
R16867 T22006 T22008 causeOf T-bet,essential
R16868 T22009 T22010 themeOf IFN-γ,expression
R16869 T22010 T22008 themeOf expression,essential
R16870 T22011 T22012 themeOf Runx3,present
R16871 T22011 T22014 causeOf Runx3,represses
R16872 T22011 T22019 causeOf Runx3,induces
R16873 T22011 T22017 causeOf Runx3,induces
R16874 T22011 T22018 causeOf Runx3,induces
R16875 T22011 T22016 causeOf Runx3,induces
R16876 T22015 T22014 themeOf Runx1,represses
R16877 T22020 T22026 themeOf Eomes,expression
R16878 T22021 T22027 themeOf perforin,expression
R16879 T22022 T22024 themeOf granzyme B,expression
R16880 T22023 T22025 themeOf IFN-γ,expression
R16881 T22024 T22018 themeOf expression,induces
R16882 T22025 T22016 themeOf expression,induces
R16883 T22026 T22019 themeOf expression,induces
R16884 T22027 T22017 themeOf expression,induces
R16885 T22028 T22029 causeOf Eomes,participate
R16886 T22030 T22031 themeOf IFN-γ,expression
R16887 T22031 T22029 themeOf expression,participate
R16888 T22032 T22036 causeOf Runx3,activate
R16889 T22033 T22035 causeOf Eomes,activate
R16890 T22034 T22037 causeOf T-bet,activate
R16891 T22038 T22039 themeOf perforin,expression
R16892 T22039 T22036 themeOf expression,activate
R16893 T22039 T22035 themeOf expression,activate
R16894 T22039 T22037 themeOf expression,activate
R16895 T22042 T22043 themeOf T-bet,deficiency
R16896 T22043 T22040 causeOf deficiency,effect
R16897 T22043 T22041 causeOf deficiency,effect
R16898 T22044 T22046 themeOf Gzmb,expression
R16899 T22045 T22047 themeOf granzyme B,expression
R16900 T22046 T22040 themeOf expression,effect
R16901 T22047 T22041 themeOf expression,effect

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T11239 0-5 Protein denotes Runx3
T11240 111-116 Protein denotes Runx3
T11241 151-155 Protein denotes CD8+
T11242 184-195 Protein denotes T-bet-Runx3
T11243 231-235 Protein denotes CD4+
T11244 274-279 Protein denotes Runx3
T11245 127-136 Gene_expression denotes expressed
T11246 325-328 Protein denotes CD8
T11247 343-348 Protein denotes Runx3
T11248 402-404 Protein denotes WT
T11249 405-410 Protein denotes Runx3
T11250 523-526 Protein denotes org
T11251 527-530 Protein denotes cgi
T11252 575-580 Protein denotes Runx3
T11253 584-587 Protein denotes CD8
T11254 701-709 Protein denotes perforin
T11255 711-721 Protein denotes granzyme B
T11256 727-732 Protein denotes IFN-γ
T11257 734-737 Protein denotes Fig
T11258 687-697 Gene_expression denotes expression
T11259 687-697 Gene_expression denotes expression
T11260 687-697 Gene_expression denotes expression
T11261 687-697 Gene_expression denotes expression
T11262 769-782 Protein denotes perforin mRNA
T11263 839-844 Protein denotes Runx3
T11264 795-805 Gene_expression denotes expression
T11265 823-835 Positive_regulation denotes undetectable
T11266 895-900 Protein denotes Runx3
T11267 1023-1028 Protein denotes Runx3
T11268 1068-1073 Protein denotes IFN-γ
T11269 1083-1086 Protein denotes TNF
T11270 1090-1094 Protein denotes IL-2
T11271 1099-1103 Protein denotes CD8+
T11272 1054-1064 Gene_expression denotes production
T11273 1054-1064 Gene_expression denotes production
T11274 1054-1064 Gene_expression denotes production
T11275 1033-1041 Positive_regulation denotes required
T11276 1033-1041 Positive_regulation denotes required
T11277 1033-1041 Positive_regulation denotes required
T11278 2428-2433 Protein denotes Runx3
T11279 2457-2462 Protein denotes Runx3
T11280 2483-2505 Protein denotes IFN-γ and silence IL-4
T11281 2420-2427 Positive_regulation denotes induces
T11282 2590-2595 Protein denotes Runx3
T11283 2704-2712 Protein denotes perforin
T11284 2760-2762 Protein denotes Eo
T11285 2763-2767 Protein denotes VP16
T11286 2835-2843 Protein denotes perforin
T11287 2848-2853 Protein denotes IFN-γ
T11288 3011-3015 Protein denotes Runx
T11289 3020-3047 Protein denotes T-box transcription factors
T11290 2713-2723 Gene_expression denotes expression
T11291 2742-2756 Positive_regulation denotes overexpression
T11292 2742-2756 Positive_regulation denotes overexpression
T11293 2818-2826 Positive_regulation denotes increase
T11294 2854-2864 Gene_expression denotes expression
T11295 2854-2864 Gene_expression denotes expression
T11296 2975-2984 Regulation denotes involving
T11297 2975-2984 Regulation denotes involving
T11298 2808-2811 Positive_regulation denotes led
T11299 2808-2811 Positive_regulation denotes led
T11300 2818-2826 Positive_regulation denotes increase
T11301 2818-2826 Positive_regulation denotes increase
T11302 3080-3085 Protein denotes Runx3
T11303 3209-3217 Protein denotes perforin
T11304 3219-3224 Protein denotes IFN-γ
T11305 3230-3240 Protein denotes granzyme B
T11306 3167-3180 Transcription denotes transcription
T11307 3167-3180 Transcription denotes transcription
T11308 3167-3180 Transcription denotes transcription
T11309 3158-3166 Regulation denotes regulate
T11310 3158-3166 Regulation denotes regulate
T11311 3158-3166 Regulation denotes regulate
T11312 3334-3339 Protein denotes Eomes
T11313 3344-3349 Protein denotes Runx3
T11314 3382-3386 Protein denotes Prf1
T11315 3388-3392 Protein denotes Ifng
T11316 3398-3408 Protein denotes Gzmb genes
T11317 3410-3413 Protein denotes Fig
T11318 3367-3374 Entity denotes regions
T11319 3350-3355 Binding denotes bound
T11320 3350-3355 Binding denotes bound
T11321 3350-3355 Binding denotes bound
T11322 3350-3355 Binding denotes bound
T11323 3350-3355 Binding denotes bound
T11324 3350-3355 Binding denotes bound
T11325 3499-3504 Protein denotes Runx3
T11326 3518-3522 Protein denotes Prf1
T11327 3527-3531 Protein denotes Gzmb
T11328 3627-3631 Protein denotes Prf1
T11329 3670-3677 Protein denotes DNase I
T11330 3707-3711 Protein denotes Prf1
T11331 3731-3744 Protein denotes Ifng promoter
T11332 3817-3824 Protein denotes DNase I
T11333 3505-3510 Binding denotes bound
T11334 3927-3935 Protein denotes Prf1 TSS
T11335 4041-4051 Protein denotes Il2rb gene
T11336 4128-4136 Protein denotes Ifng TSS
T11337 4156-4170 Protein denotes T-box proteins
T11338 4179-4182 Protein denotes Th1
T11339 4187-4191 Protein denotes CD8+
T11340 3950-3958 Entity denotes enhancer
T11341 4025-4033 Entity denotes promoter
T11342 4068-4074 Binding denotes target
T11343 4146-4152 Binding denotes target
T11344 3904-3909 Binding denotes bound
T11345 4238-4243 Protein denotes Runx3
T11346 4273-4291 Protein denotes CTL effector genes
T11347 4350-4355 Protein denotes Runx3
T11348 4360-4367 Protein denotes Eo-VP16
T11349 4371-4375 Protein denotes CD8+
T11350 4389-4394 Protein denotes Runx3
T11351 4259-4269 Gene_expression denotes expression
T11352 4340-4349 Gene_expression denotes expressed
T11353 4340-4349 Gene_expression denotes expressed
T11354 4244-4254 Regulation denotes controlled
T11355 4437-4441 Protein denotes CD8+
T11356 4506-4511 Protein denotes Runx3
T11357 4515-4518 Protein denotes CD8
T11358 4519-4522 Protein denotes CD4
T11359 4524-4526 Protein denotes SP
T11360 4531-4534 Protein denotes CD8
T11361 4535-4538 Protein denotes CD4
T11362 4592-4597 Protein denotes Runx3
T11363 4601-4604 Protein denotes CD8
T11364 4705-4710 Protein denotes Runx3
T11365 4714-4717 Protein denotes CD8
T11366 4732-4737 Protein denotes Runx3
T11367 4778-4786 Protein denotes perforin
T11368 4788-4798 Protein denotes granzyme B
T11369 4804-4809 Protein denotes IFN-γ
T11370 4811-4814 Protein denotes Fig
T11371 4738-4746 Positive_regulation denotes restored
T11372 4747-4757 Gene_expression denotes expression
T11373 4747-4757 Gene_expression denotes expression
T11374 4747-4757 Gene_expression denotes expression
T11375 4747-4757 Gene_expression denotes expression
T11376 4738-4746 Positive_regulation denotes restored
T11377 4738-4746 Positive_regulation denotes restored
T11378 4738-4746 Positive_regulation denotes restored
T11379 4738-4746 Positive_regulation denotes restored
T11380 4842-4847 Protein denotes Runx3
T11381 4898-4903 Protein denotes Runx1
T11382 4951-4956 Protein denotes Runx3
T11383 4974-4979 Protein denotes Runx1
T11384 5009-5014 Protein denotes Runx3
T11385 4881-4894 Positive_regulation denotes up-regulation
T11386 4915-4925 Negative_regulation denotes suppressed
T11387 4995-5005 Negative_regulation denotes repression
T11388 5025-5032 Protein denotes Eo-VP16
T11389 5053-5061 Protein denotes perforin
T11390 5091-5096 Protein denotes Runx3
T11391 5154-5159 Protein denotes IFN-γ
T11392 5176-5179 Protein denotes TCR
T11393 5062-5072 Gene_expression denotes expression
T11394 5160-5170 Gene_expression denotes expression
T11395 5180-5193 Positive_regulation denotes restimulation
T11396 5041-5052 Positive_regulation denotes up-regulate
T11397 5147-5153 Positive_regulation denotes induce
T11398 5122-5130 Positive_regulation denotes restored
T11399 5248-5256 Protein denotes perforin
T11400 5277-5282 Protein denotes Runx3
T11401 5287-5292 Protein denotes Eomes
T11402 5257-5267 Gene_expression denotes expression
T11403 6998-7006 Protein denotes perforin
T11404 7011-7021 Protein denotes granzyme B
T11405 7034-7039 Protein denotes Runx3
T11406 7043-7046 Protein denotes CD8
T11407 7022-7032 Gene_expression denotes expression
T11408 7022-7032 Gene_expression denotes expression
T11409 6988-6994 Positive_regulation denotes defect
T11410 6988-6994 Positive_regulation denotes defect
T11411 7138-7141 Protein denotes TCR
T11412 7153-7158 Protein denotes Runx3
T11413 7162-7165 Protein denotes CD8
T11414 7271-7275 Protein denotes CD8+
T11415 7312-7317 Protein denotes Runx3
T11416 7438-7457 Protein denotes perforin/granzyme B
T11417 7484-7489 Protein denotes Runx3
T11418 7493-7497 Protein denotes CD8+
T11419 7652-7655 Protein denotes Fas
T11420 7656-7659 Protein denotes Fas
T11421 7420-7430 Positive_regulation denotes activation
T11422 7471-7480 Negative_regulation denotes defective
T20707 1169-1174 Protein denotes Runx3
T20708 1232-1237 Protein denotes Runx3
T20709 1257-1265 Protein denotes perforin
T20710 1280-1285 Protein denotes Runx3
T20711 1305-1308 Protein denotes CD8
T20712 1310-1314 Protein denotes SP T
T20713 1266-1276 Gene_expression denotes expression
T20714 1266-1276 Gene_expression denotes expression
T20715 1347-1352 Protein denotes Actin
T20716 1414-1423 Protein denotes Prf1 mRNA
T20717 1438-1443 Protein denotes Runx3
T20718 1463-1466 Protein denotes CD8
T20719 1424-1434 Gene_expression denotes expression
T20720 1502-1507 Protein denotes Actin
T20721 1557-1567 Protein denotes granzyme B
T20722 1569-1574 Protein denotes IFN-γ
T20723 1576-1579 Protein denotes TNF
T20724 1585-1589 Protein denotes IL-2
T20725 1623-1628 Protein denotes Runx3
T20726 1648-1651 Protein denotes CD8
T20727 1653-1657 Protein denotes SP T
T20728 1543-1553 Gene_expression denotes Expression
T20729 1543-1553 Gene_expression denotes Expression
T20730 1543-1553 Gene_expression denotes Expression
T20731 1543-1553 Gene_expression denotes Expression
T20732 1744-1750 Protein denotes WT GFP
T20733 1857-1873 Protein denotes endogenous Runx3
T20734 1878-1883 Protein denotes Eomes
T20735 1891-1901 Protein denotes Prf1 locus
T20736 1846-1853 Binding denotes binding
T20737 1846-1853 Binding denotes binding
T20738 1846-1853 Binding denotes binding
T20739 1846-1853 Binding denotes binding
T20740 2132-2136 Protein denotes CD8+
T20741 2222-2226 Protein denotes Prf1
T20742 2245-2255 Protein denotes Runx3 ChIP
T20743 2273-2283 Protein denotes Eomes ChIP
T22048 5304-5309 Protein denotes Runx3
T22049 5326-5334 Protein denotes perforin
T22050 5336-5346 Protein denotes granzyme B
T22051 5352-5357 Protein denotes IFN-γ
T22052 5310-5318 Regulation denotes controls
T22053 5310-5318 Regulation denotes controls
T22054 5358-5368 Gene_expression denotes expression
T22055 5358-5368 Gene_expression denotes expression
T22056 5358-5368 Gene_expression denotes expression
T22057 5310-5318 Regulation denotes controls
T22058 5310-5318 Regulation denotes controls
T22059 5310-5318 Regulation denotes controls
T22060 5387-5392 Protein denotes Runx3
T22061 5399-5404 Protein denotes Runx3
T22062 5408-5411 Protein denotes CD8
T22063 5486-5503 Protein denotes IRES-GFP cassette
T22064 5505-5508 Protein denotes GFP
T22065 5527-5537 Protein denotes Eomes-VP16
T22066 5539-5541 Protein denotes Eo
T22067 5542-5546 Protein denotes VP16
T22068 5551-5554 Protein denotes Myc
T22069 5555-5560 Protein denotes Runx3
T22070 5562-5567 Protein denotes Runx3
T22071 5794-5799 Protein denotes Eomes
T22072 5800-5804 Protein denotes VP16
T22073 5928-5955 Protein denotes VP16 transactivation domain
T22074 5776-5790 Positive_regulation denotes Overexpression
T22075 5776-5790 Positive_regulation denotes Overexpression
T22076 5975-5985 Protein denotes granzyme B
T22077 5990-5995 Protein denotes IFN-γ
T22078 5961-5971 Gene_expression denotes Expression
T22079 5961-5971 Gene_expression denotes Expression
T22080 6218-6228 Protein denotes granzyme B
T22081 6229-6237 Gene_expression denotes staining
T22082 6333-6339 Protein denotes WT GFP
T22083 6479-6484 Protein denotes Runx3
T22084 6489-6502 Protein denotes T-box factors
T22085 6524-6527 Protein denotes TCR
T22086 6563-6568 Protein denotes IFN-γ
T22087 6569-6579 Gene_expression denotes expression
T22088 6543-6552 Positive_regulation denotes essential
T22089 6581-6586 Protein denotes Runx3
T22090 6607-6611 Protein denotes CD8+
T22091 6634-6639 Protein denotes Runx1
T22092 6652-6657 Protein denotes Eomes
T22093 6659-6667 Protein denotes perforin
T22094 6669-6679 Protein denotes granzyme B
T22095 6685-6690 Protein denotes IFN-γ
T22096 6590-6597 Gene_expression denotes present
T22097 6624-6633 Negative_regulation denotes represses
T22098 6691-6701 Gene_expression denotes expression
T22099 6691-6701 Gene_expression denotes expression
T22100 6744-6749 Protein denotes IFN-γ
T22101 6770-6775 Protein denotes Runx3
T22102 6828-6836 Protein denotes perforin
T22103 6750-6760 Gene_expression denotes expression
T22104 6837-6847 Gene_expression denotes expression
T22105 6713-6724 Regulation denotes participate
T22106 6819-6827 Positive_regulation denotes activate
T22107 6917-6926 Protein denotes Gzmb mRNA
T22108 6935-6953 Protein denotes granzyme B protein
T22109 6954-6964 Gene_expression denotes expression
T22110 6954-6964 Gene_expression denotes expression
T22111 6887-6893 Regulation denotes effect
T22112 6887-6893 Regulation denotes effect
R8797 T11240 T11245 themeOf Runx3,expressed
R8802 T11254 T11258 themeOf perforin,expression
R8804 T11255 T11259 themeOf granzyme B,expression
R8805 T11256 T11260 themeOf IFN-γ,expression
R8806 T11257 T11261 themeOf Fig,expression
R8809 T11262 T11264 themeOf perforin mRNA,expression
R8810 T11262 T11265 causeOf perforin mRNA,undetectable
R8812 T11264 T11265 themeOf expression,undetectable
R8817 T11267 T11275 causeOf Runx3,required
R8818 T11267 T11276 causeOf Runx3,required
R8819 T11267 T11277 causeOf Runx3,required
R8820 T11268 T11272 themeOf IFN-γ,production
R8821 T11269 T11273 themeOf TNF,production
R8822 T11270 T11274 themeOf IL-2,production
R8823 T11272 T11275 themeOf production,required
R8824 T11273 T11276 themeOf production,required
R8826 T11274 T11277 themeOf production,required
R8828 T11278 T11281 themeOf Runx3,induces
R8833 T11283 T11290 themeOf perforin,expression
R8834 T11284 T11291 themeOf Eo,overexpression
R8835 T11285 T11292 themeOf VP16,overexpression
R8836 T11286 T11293 themeOf perforin,increase
R8837 T11286 T11294 themeOf perforin,expression
R8843 T11287 T11295 themeOf IFN-γ,expression
R8845 T11288 T11296 themeOf Runx,involving
R8846 T11289 T11297 themeOf T-box transcription factors,involving
R8847 T11291 T11298 causeOf overexpression,led
R8848 T11292 T11299 causeOf overexpression,led
R8849 T11293 T11298 themeOf increase,led
R8850 T11293 T11299 themeOf increase,led
R8851 T11294 T11300 themeOf expression,increase
R8852 T11295 T11301 themeOf expression,increase
R8855 T11302 T11309 causeOf Runx3,regulate
R8856 T11302 T11310 causeOf Runx3,regulate
R8857 T11302 T11311 causeOf Runx3,regulate
R8858 T11303 T11306 themeOf perforin,transcription
R8860 T11304 T11307 themeOf IFN-γ,transcription
R8862 T11305 T11308 themeOf granzyme B,transcription
R8863 T11306 T11309 themeOf transcription,regulate
R8864 T11307 T11310 themeOf transcription,regulate
R8866 T11308 T11311 themeOf transcription,regulate
R8868 T11312 T11319 themeOf Eomes,bound
R8869 T11312 T11320 themeOf Eomes,bound
R8870 T11312 T11321 themeOf Eomes,bound
R8871 T11313 T11322 themeOf Runx3,bound
R8872 T11313 T11323 themeOf Runx3,bound
R8873 T11313 T11324 themeOf Runx3,bound
R8874 T11314 T11319 themeOf Prf1,bound
R8875 T11314 T11322 themeOf Prf1,bound
R8876 T11314 T11318 partOf Prf1,regions
R8877 T11315 T11320 themeOf Ifng,bound
R8878 T11315 T11323 themeOf Ifng,bound
R8879 T11315 T11318 partOf Ifng,regions
R8880 T11316 T11318 partOf Gzmb genes,regions
R8881 T11317 T11321 themeOf Fig,bound
R8882 T11317 T11324 themeOf Fig,bound
R8883 T11317 T11318 partOf Fig,regions
R8884 T11318 T11319 Site regions,bound
R8885 T11318 T11320 Site regions,bound
R8886 T11318 T11321 Site regions,bound
R8887 T11318 T11322 Site regions,bound
R8888 T11318 T11323 Site regions,bound
R8889 T11318 T11324 Site regions,bound
R8891 T11325 T11333 themeOf Runx3,bound
R8894 T11351 T11354 themeOf expression,controlled
R8895 T11331 T11333 themeOf Ifng promoter,bound
R8896 T11334 T11344 themeOf Prf1 TSS,bound
R8897 T11334 T11340 partOf Prf1 TSS,enhancer
R8898 T11335 T11342 themeOf Il2rb gene,target
R8899 T11335 T11341 partOf Il2rb gene,promoter
R8900 T11336 T11343 themeOf Ifng TSS,target
R8901 T11337 T11343 themeOf T-box proteins,target
R8902 T11340 T11344 Site enhancer,bound
R8903 T11341 T11342 Site promoter,target
R8904 T11367 T11371 themeOf perforin,restored
R8905 T11345 T11354 causeOf Runx3,controlled
R8906 T11346 T11351 themeOf CTL effector genes,expression
R8907 T11347 T11352 themeOf Runx3,expressed
R8908 T11348 T11353 themeOf Eo-VP16,expressed
R8909 T11367 T11372 themeOf perforin,expression
R8910 T11368 T11373 themeOf granzyme B,expression
R8911 T11369 T11374 themeOf IFN-γ,expression
R8912 T11370 T11375 themeOf Fig,expression
R8913 T11372 T11376 themeOf expression,restored
R8914 T11373 T11377 themeOf expression,restored
R8915 T11374 T11378 themeOf expression,restored
R8916 T11375 T11379 themeOf expression,restored
R8917 T11381 T11385 themeOf Runx1,up-regulation
R8918 T11382 T11386 causeOf Runx3,suppressed
R8919 T11383 T11387 themeOf Runx1,repression
R8920 T11384 T11387 causeOf Runx3,repression
R8921 T11385 T11386 themeOf up-regulation,suppressed
R8922 T11388 T11396 causeOf Eo-VP16,up-regulate
R8923 T11389 T11393 themeOf perforin,expression
R8924 T11391 T11394 themeOf IFN-γ,expression
R8925 T11392 T11395 themeOf TCR,restimulation
R8926 T11393 T11396 themeOf expression,up-regulate
R8927 T11394 T11397 themeOf expression,induce
R8928 T11395 T11397 causeOf restimulation,induce
R8929 T11397 T11398 themeOf induce,restored
R8930 T11399 T11402 themeOf perforin,expression
R8931 T11403 T11407 themeOf perforin,expression
R8932 T11404 T11408 themeOf granzyme B,expression
R8933 T11407 T11409 themeOf expression,defect
R8934 T11408 T11410 themeOf expression,defect
R8935 T11416 T11421 themeOf perforin/granzyme B,activation
R8936 T11421 T11422 themeOf activation,defective
R15867 T20708 T20713 themeOf Runx3,expression
R15868 T20709 T20714 themeOf perforin,expression
R15869 T20716 T20719 themeOf Prf1 mRNA,expression
R15870 T20721 T20728 themeOf granzyme B,Expression
R15871 T20722 T20729 themeOf IFN-γ,Expression
R15872 T20723 T20730 themeOf TNF,Expression
R15873 T20724 T20731 themeOf IL-2,Expression
R15874 T20733 T20736 themeOf endogenous Runx3,binding
R15875 T20733 T20738 themeOf endogenous Runx3,binding
R15876 T20734 T20737 themeOf Eomes,binding
R15877 T20734 T20739 themeOf Eomes,binding
R15878 T20735 T20738 themeOf Prf1 locus,binding
R15879 T20735 T20739 themeOf Prf1 locus,binding
R16902 T22048 T22052 causeOf Runx3,controls
R16903 T22048 T22053 causeOf Runx3,controls
R16904 T22048 T22057 causeOf Runx3,controls
R16905 T22048 T22058 causeOf Runx3,controls
R16906 T22048 T22059 causeOf Runx3,controls
R16907 T22049 T22052 themeOf perforin,controls
R16908 T22049 T22054 themeOf perforin,expression
R16909 T22050 T22053 themeOf granzyme B,controls
R16910 T22050 T22055 themeOf granzyme B,expression
R16911 T22051 T22056 themeOf IFN-γ,expression
R16912 T22054 T22057 themeOf expression,controls
R16913 T22055 T22058 themeOf expression,controls
R16914 T22056 T22059 themeOf expression,controls
R16915 T22071 T22074 themeOf Eomes,Overexpression
R16916 T22072 T22075 themeOf VP16,Overexpression
R16917 T22076 T22078 themeOf granzyme B,Expression
R16918 T22077 T22079 themeOf IFN-γ,Expression
R16919 T22080 T22081 themeOf granzyme B,staining
R16920 T22086 T22087 themeOf IFN-γ,expression
R16921 T22087 T22088 themeOf expression,essential
R16922 T22089 T22096 themeOf Runx3,present
R16923 T22089 T22097 causeOf Runx3,represses
R16924 T22091 T22097 themeOf Runx1,represses
R16925 T22092 T22098 themeOf Eomes,expression
R16926 T22095 T22099 themeOf IFN-γ,expression
R16927 T22100 T22103 themeOf IFN-γ,expression
R16928 T22101 T22106 causeOf Runx3,activate
R16929 T22102 T22104 themeOf perforin,expression
R16930 T22103 T22105 themeOf expression,participate
R16931 T22104 T22106 themeOf expression,activate
R16932 T22107 T22109 themeOf Gzmb mRNA,expression
R16933 T22107 T22111 causeOf Gzmb mRNA,effect
R16934 T22107 T22112 causeOf Gzmb mRNA,effect
R16935 T22108 T22110 themeOf granzyme B protein,expression
R16936 T22109 T22111 themeOf expression,effect
R16937 T22110 T22112 themeOf expression,effect

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T7771 727-732 Protein denotes IFN-γ
T7772 769-777 Protein denotes perforin
T7773 795-805 Gene_expression denotes expression
T7774 823-835 Positive_regulation denotes undetectable true
T7775 839-844 Protein denotes Runx3
T7776 895-900 Protein denotes Runx3
T7777 935-940 Protein denotes Eomes
T7778 941-951 Gene_expression denotes expression true
T7779 966-971 Protein denotes T-bet
T7780 972-982 Gene_expression denotes expression
T7781 987-997 Negative_regulation denotes unimpaired true
T7782 1023-1028 Protein denotes Runx3
T7783 1033-1041 Positive_regulation denotes required
T7784 1033-1041 Positive_regulation denotes required
T7785 1033-1041 Positive_regulation denotes required
T7786 1054-1064 Gene_expression denotes production
T7787 1054-1064 Gene_expression denotes production
T7788 1054-1064 Gene_expression denotes production
T7789 1068-1073 Protein denotes IFN-γ
T7790 1083-1086 Protein denotes TNF
T7791 1090-1094 Protein denotes IL-2
T7792 1099-1102 Protein denotes CD8
T7793 2388-2393 Protein denotes T-bet
T7794 2397-2409 Positive_regulation denotes up-regulated
T7795 2420-2427 Positive_regulation denotes induces
T7796 2428-2433 Protein denotes Runx3
T7797 2447-2452 Protein denotes T-bet
T7798 2457-2462 Protein denotes Runx3
T7799 2476-2482 Positive_regulation denotes induce
T7800 2476-2482 Positive_regulation denotes induce
T7801 2483-2488 Protein denotes IFN-γ
T7802 2493-2500 Negative_regulation denotes silence
T7803 2493-2500 Negative_regulation denotes silence
T7804 2501-2505 Protein denotes IL-4
T7805 2590-2595 Protein denotes Runx3
T7806 2605-2614 Positive_regulation denotes necessary true
T7807 2619-2624 Protein denotes Eomes
T7808 2625-2634 Positive_regulation denotes induction
T7809 2667-2672 Protein denotes Eomes
T7810 2673-2683 Gene_expression denotes expression
T7811 2704-2712 Protein denotes perforin
T7812 2713-2723 Gene_expression denotes expression
T7813 2742-2756 Positive_regulation denotes overexpression
T7814 2760-2767 Protein denotes Eo-VP16
T7815 2784-2789 Protein denotes T-bet
T7816 2790-2799 Negative_regulation denotes deficient
T7817 2808-2811 Positive_regulation denotes led
T7818 2808-2811 Positive_regulation denotes led
T7819 2818-2826 Positive_regulation denotes increase
T7820 2818-2826 Positive_regulation denotes increase
T7821 2835-2843 Protein denotes perforin
T7822 2848-2853 Protein denotes IFN-γ
T7823 2854-2864 Gene_expression denotes expression
T7824 2854-2864 Gene_expression denotes expression
T7825 3080-3085 Protein denotes Runx3
T7826 3097-3106 Positive_regulation denotes necessary true
T7827 3111-3116 Protein denotes Eomes
T7828 3117-3126 Positive_regulation denotes induction
T7829 3149-3154 Protein denotes Eomes
T7830 3158-3166 Regulation denotes regulate
T7831 3158-3166 Regulation denotes regulate
T7832 3158-3166 Regulation denotes regulate
T7833 3158-3166 Regulation denotes regulate
T7834 3158-3166 Regulation denotes regulate
T7835 3158-3166 Regulation denotes regulate
T7836 3167-3180 Transcription denotes transcription
T7837 3167-3180 Transcription denotes transcription
T7838 3167-3180 Transcription denotes transcription
T7839 3209-3217 Protein denotes perforin
T7840 3219-3224 Protein denotes IFN-γ
T7841 3230-3240 Protein denotes granzyme B
T7842 3334-3339 Protein denotes Eomes
T7843 3344-3349 Protein denotes Runx3
T7844 3350-3355 Binding denotes bound true
T7845 3350-3355 Binding denotes bound true
T7846 3350-3355 Binding denotes bound true
T7847 3350-3355 Binding denotes bound true
T7848 3350-3355 Binding denotes bound true
T7849 3350-3355 Binding denotes bound true
T7850 3356-3374 Entity denotes regulatory regions
T7851 3382-3386 Protein denotes Prf1
T7852 3388-3392 Protein denotes Ifng
T7853 3398-3402 Protein denotes Gzmb
T7854 3435-3445 Binding denotes associated
T7855 3435-3445 Binding denotes associated
T7856 3499-3504 Protein denotes Runx3
T7857 3505-3510 Binding denotes bound
T7858 3505-3510 Binding denotes bound
T7859 3518-3522 Protein denotes Prf1
T7860 3527-3531 Protein denotes Gzmb
T7861 3532-3557 Entity denotes transcription start sites
T7862 3627-3631 Protein denotes Prf1
T7863 3707-3711 Protein denotes Prf1
T7864 3731-3735 Protein denotes Ifng
T7865 3853-3857 Protein denotes Ifng
T7866 3898-3903 Protein denotes Eomes
T7867 3904-3909 Binding denotes bound
T7868 3904-3909 Binding denotes bound
T7869 3927-3931 Protein denotes Prf1
T7870 3932-3935 Entity denotes TSS
T7879 4133-4136 Entity denotes TSS
T7880 4146-4152 Binding denotes target
T7881 4187-4190 Protein denotes CD8
T7882 4238-4243 Protein denotes Runx3
T7883 4304-4313 Positive_regulation denotes induction
T7884 4317-4322 Protein denotes Eomes
T7885 4340-4349 Gene_expression denotes expressed
T7886 4340-4349 Gene_expression denotes expressed
T7887 4350-4355 Protein denotes Runx3
T7888 4360-4367 Protein denotes Eo-VP16
T7889 4371-4374 Protein denotes CD8
T7890 4389-4394 Protein denotes Runx3
T7891 4437-4440 Protein denotes CD8
T7892 4506-4511 Protein denotes Runx3
T7893 4515-4518 Protein denotes CD8
T7894 4519-4522 Protein denotes CD4
T7895 4531-4534 Protein denotes CD8
T7896 4535-4538 Protein denotes CD4
T7897 4592-4597 Protein denotes Runx3
T7898 4601-4604 Protein denotes CD8
T7899 4705-4710 Protein denotes Runx3
T7900 4714-4717 Protein denotes CD8
T7901 4732-4737 Protein denotes Runx3
T7902 4738-4746 Positive_regulation denotes restored
T7903 4738-4746 Positive_regulation denotes restored
T7904 4738-4746 Positive_regulation denotes restored
T7905 4738-4746 Positive_regulation denotes restored
T7906 4747-4757 Gene_expression denotes expression
T7907 4747-4757 Gene_expression denotes expression
T7908 4747-4757 Gene_expression denotes expression
T7909 4747-4757 Gene_expression denotes expression
T7910 4761-4766 Protein denotes Eomes
T7911 4778-4786 Protein denotes perforin
T7912 4788-4798 Protein denotes granzyme B
T7913 4804-4809 Protein denotes IFN-γ
T7914 4842-4847 Protein denotes Runx3
T7915 4881-4894 Positive_regulation denotes up-regulation
T7916 4898-4903 Protein denotes Runx1
T7917 4915-4925 Negative_regulation denotes suppressed
T7918 4951-4956 Protein denotes Runx3
T7919 4974-4979 Protein denotes Runx1
T7920 4995-5005 Negative_regulation denotes repression
T7921 5009-5014 Protein denotes Runx3
T7922 5025-5032 Protein denotes Eo-VP16
T7923 5041-5052 Positive_regulation denotes up-regulate true
T7924 5053-5061 Protein denotes perforin
T7925 5062-5072 Gene_expression denotes expression
T7926 5078-5087 Gene_expression denotes expressed
T7927 5091-5096 Protein denotes Runx3
T7928 5122-5130 Positive_regulation denotes restored
T7929 5147-5153 Positive_regulation denotes induce
T7930 5154-5159 Protein denotes IFN-γ
T7931 5160-5170 Gene_expression denotes expression
T7932 5248-5256 Protein denotes perforin
T7933 5257-5267 Gene_expression denotes expression
T7934 5268-5276 Positive_regulation denotes requires true
T7935 5268-5276 Positive_regulation denotes requires true
T7936 5277-5282 Protein denotes Runx3
T7937 5287-5292 Protein denotes Eomes
T7938 6988-6994 Positive_regulation denotes defect true
T7939 6988-6994 Positive_regulation denotes defect true
T7940 6988-6994 Positive_regulation denotes defect true
T7941 6988-6994 Positive_regulation denotes defect true
T7942 6998-7006 Protein denotes perforin
T7943 7011-7021 Protein denotes granzyme B
T7944 7022-7032 Gene_expression denotes expression
T7945 7022-7032 Gene_expression denotes expression
T7946 7034-7039 Protein denotes Runx3
T7947 7043-7046 Protein denotes CD8
T7948 7153-7158 Protein denotes Runx3
T7949 7162-7165 Protein denotes CD8
T7950 7271-7274 Protein denotes CD8
T7951 7312-7317 Protein denotes Runx3
T7952 7420-7430 Positive_regulation denotes activation
T7953 7420-7430 Positive_regulation denotes activation
T7954 7438-7446 Protein denotes perforin
T7955 7447-7457 Protein denotes granzyme B
T7956 7471-7480 Negative_regulation denotes defective
T7957 7471-7480 Negative_regulation denotes defective
T7958 7484-7489 Protein denotes Runx3
T7959 7493-7496 Protein denotes CD8
T7960 7652-7655 Protein denotes Fas
T7961 7656-7666 Protein denotes Fas ligand
T20168 1868-1873 Protein denotes Runx3
T20169 1878-1883 Protein denotes Eomes
T20170 1891-1895 Protein denotes Prf1
T20893 5527-5537 Protein denotes Eomes-VP16
T20894 5539-5546 Protein denotes Eo-VP16
T20895 5551-5554 Protein denotes Myc
T20896 5555-5560 Protein denotes Runx3
T20897 5562-5567 Protein denotes Runx3
T20898 5776-5790 Positive_regulation denotes Overexpression
T20899 5794-5804 Protein denotes Eomes-VP16
T20900 5833-5838 Protein denotes Eomes
T20901 5928-5932 Protein denotes VP16
T20902 5961-5971 Gene_expression denotes Expression true
T20903 5961-5971 Gene_expression denotes Expression true
T20904 5975-5985 Protein denotes granzyme B
T20905 5990-5995 Protein denotes IFN-γ
T20929 6691-6701 Gene_expression denotes expression
T20930 6691-6701 Gene_expression denotes expression
T20931 6691-6701 Gene_expression denotes expression
T20932 6703-6708 Protein denotes Eomes
T20933 6713-6724 Regulation denotes participate true
T20934 6744-6749 Protein denotes IFN-γ
T20935 6750-6760 Gene_expression denotes expression
T20936 6770-6775 Protein denotes Runx3
T20937 6780-6785 Protein denotes Eomes
T20938 6795-6800 Protein denotes T-bet
T20939 6819-6827 Positive_regulation denotes activate true
T20940 6819-6827 Positive_regulation denotes activate true
T20941 6819-6827 Positive_regulation denotes activate true true
T20942 6828-6836 Protein denotes perforin
T20943 6837-6847 Gene_expression denotes expression
T20944 6887-6893 Regulation denotes effect
T20945 6887-6893 Regulation denotes effect
T20946 6897-6902 Protein denotes T-bet
T20947 6903-6913 Negative_regulation denotes deficiency
T20948 6917-6921 Protein denotes Gzmb
T20949 6935-6945 Protein denotes granzyme B
T20950 6954-6964 Gene_expression denotes expression
T20951 6954-6964 Gene_expression denotes expression true
T20134 1169-1174 Protein denotes Runx3
T20135 1232-1237 Protein denotes Runx3
T20136 1239-1244 Protein denotes Eomes
T20137 1246-1251 Protein denotes T-bet
T20138 1257-1265 Protein denotes perforin
T20139 1266-1276 Gene_expression denotes expression true
T20140 1266-1276 Gene_expression denotes expression true
T20141 1266-1276 Gene_expression denotes expression true
T20142 1266-1276 Gene_expression denotes expression true
T20143 1280-1285 Protein denotes Runx3
T20144 1296-1301 Protein denotes Runx3
T20145 1305-1308 Protein denotes CD8
T20146 1345-1352 Protein denotes β-Actin
T20147 1414-1418 Protein denotes Prf1
T20148 1419-1434 Transcription denotes mRNA expression true
T20149 1438-1443 Protein denotes Runx3
T20150 1454-1459 Protein denotes Runx3
T20151 1463-1466 Protein denotes CD8
T20152 1500-1507 Protein denotes β–Actin
T20153 1543-1553 Gene_expression denotes Expression true
T20154 1543-1553 Gene_expression denotes Expression true
T20155 1543-1553 Gene_expression denotes Expression true
T20156 1543-1553 Gene_expression denotes Expression true
T20157 1557-1567 Protein denotes granzyme B
T20158 1569-1574 Protein denotes IFN-γ
T20159 1576-1579 Protein denotes TNF
T20160 1585-1589 Protein denotes IL-2
T20161 1623-1628 Protein denotes Runx3
T20162 1639-1644 Protein denotes Runx3
T20163 1648-1651 Protein denotes CD8
T20164 1725-1735 Protein denotes granzyme B
T20165 1747-1750 Protein denotes GFP
T20166 1846-1853 Binding denotes binding true
T20167 1846-1853 Binding denotes binding true
T20171 2132-2135 Protein denotes CD8
T20172 2222-2226 Protein denotes Prf1
T20173 2245-2250 Protein denotes Runx3
T20174 2273-2278 Protein denotes Eomes
T20876 5304-5309 Protein denotes Runx3
T20877 5310-5318 Regulation denotes controls
T20878 5310-5318 Regulation denotes controls
T20879 5310-5318 Regulation denotes controls
T20880 5310-5318 Regulation denotes controls
T20881 5319-5324 Protein denotes Eomes
T20882 5326-5334 Protein denotes perforin
T20883 5336-5346 Protein denotes granzyme B
T20884 5352-5357 Protein denotes IFN-γ
T20885 5358-5368 Gene_expression denotes expression
T20886 5358-5368 Gene_expression denotes expression
T20887 5358-5368 Gene_expression denotes expression
T20888 5358-5368 Gene_expression denotes expression
T20889 5387-5392 Protein denotes Runx3
T20890 5399-5404 Protein denotes Runx3
T20891 5408-5411 Protein denotes CD8
T20892 5491-5494 Protein denotes GFP
T20906 6218-6228 Protein denotes granzyme B
T20907 6229-6237 Gene_expression denotes staining true
T20908 6336-6339 Protein denotes GFP
T20909 6479-6484 Protein denotes Runx3
T20910 6504-6509 Protein denotes T-bet
T20911 6513-6520 Positive_regulation denotes induced
T20912 6543-6552 Positive_regulation denotes essential
T20913 6563-6568 Protein denotes IFN-γ
T20914 6569-6579 Gene_expression denotes expression
T20915 6581-6586 Protein denotes Runx3
T20916 6590-6597 Gene_expression denotes present
T20917 6607-6610 Protein denotes CD8
T20918 6624-6633 Negative_regulation denotes represses
T20919 6634-6639 Protein denotes Runx1
T20920 6644-6651 Positive_regulation denotes induces
T20921 6644-6651 Positive_regulation denotes induces
T20922 6644-6651 Positive_regulation denotes induces
T20923 6644-6651 Positive_regulation denotes induces
T20924 6652-6657 Protein denotes Eomes
T20925 6659-6667 Protein denotes perforin
T20926 6669-6679 Protein denotes granzyme B
T20927 6685-6690 Protein denotes IFN-γ
T20928 6691-6701 Gene_expression denotes expression
T7750 0-5 Protein denotes Runx3
T7751 84-93 Positive_regulation denotes induction
T7752 97-102 Protein denotes Eomes
T7753 111-116 Protein denotes Runx3
T7754 127-136 Gene_expression denotes expressed
T7755 151-154 Protein denotes CD8
T7756 184-189 Protein denotes T-bet
T7757 190-195 Protein denotes Runx3
T7758 231-234 Protein denotes CD4
T7759 274-279 Protein denotes Runx3
T7760 325-328 Protein denotes CD8
T7761 343-348 Protein denotes Runx3
T7762 405-410 Protein denotes Runx3
T7763 458-461 Protein denotes CD8
T7764 575-580 Protein denotes Runx3
T7765 584-587 Protein denotes CD8
T7766 687-697 Gene_expression denotes expression true
T7767 687-697 Gene_expression denotes expression true
T7768 687-697 Gene_expression denotes expression true
T7769 701-709 Protein denotes perforin
T7770 711-721 Protein denotes granzyme B
T7871 3944-3958 Entity denotes −1 kb enhancer
T7872 4004-4008 Binding denotes that
T7873 4025-4033 Entity denotes promoter
T7874 4041-4046 Protein denotes Il2rb
T7875 4068-4074 Binding denotes target
T7876 4078-4083 Protein denotes Eomes
T7877 4107-4111 Binding denotes that
T7878 4128-4132 Protein denotes Ifng
R6026 T7752 T7751 themeOf Eomes,induction
R6037 T7782 T7783 causeOf Runx3,required
R6038 T7782 T7785 causeOf Runx3,required
R6039 T7786 T7785 themeOf production,required
R6041 T7788 T7784 themeOf production,required
R6042 T7789 T7788 themeOf IFN-γ,production
R6043 T7790 T7787 themeOf TNF,production
R6044 T7791 T7786 themeOf IL-2,production
R6045 T7793 T7794 themeOf T-bet,up-regulated
R6046 T7796 T7795 themeOf Runx3,induces
R6047 T7797 T7800 causeOf T-bet,induce
R6048 T7797 T7803 causeOf T-bet,silence
R6049 T7798 T7799 causeOf Runx3,induce
R6050 T7798 T7802 causeOf Runx3,silence
R6051 T7801 T7800 themeOf IFN-γ,induce
R6052 T7801 T7799 themeOf IFN-γ,induce
R6053 T7804 T7803 themeOf IL-4,silence
R6054 T7804 T7802 themeOf IL-4,silence
R6055 T7805 T7806 causeOf Runx3,necessary
R6056 T7807 T7808 themeOf Eomes,induction
R6057 T7808 T7806 themeOf induction,necessary
R6058 T7809 T7810 themeOf Eomes,expression
R6059 T7811 T7812 themeOf perforin,expression
R6060 T7813 T7817 causeOf overexpression,led
R6061 T7813 T7818 causeOf overexpression,led
R6062 T7814 T7813 themeOf Eo-VP16,overexpression
R6063 T7815 T7816 themeOf T-bet,deficient
R6064 T7819 T7817 themeOf increase,led
R6065 T7820 T7818 themeOf increase,led
R6066 T7821 T7824 themeOf perforin,expression
R6067 T7822 T7823 themeOf IFN-γ,expression
R6068 T7823 T7820 themeOf expression,increase
R6069 T7824 T7819 themeOf expression,increase
R6070 T7825 T7826 causeOf Runx3,necessary
R6071 T7825 T7833 causeOf Runx3,regulate
R6072 T7825 T7831 causeOf Runx3,regulate
R6073 T7825 T7835 causeOf Runx3,regulate
R6074 T7827 T7828 themeOf Eomes,induction
R6075 T7828 T7826 themeOf induction,necessary
R6076 T7829 T7832 causeOf Eomes,regulate
R6077 T7829 T7834 causeOf Eomes,regulate
R6078 T7829 T7830 causeOf Eomes,regulate
R6079 T7836 T7835 themeOf transcription,regulate
R6080 T7836 T7830 themeOf transcription,regulate
R6081 T7837 T7831 themeOf transcription,regulate
R6082 T7837 T7834 themeOf transcription,regulate
R6083 T7838 T7833 themeOf transcription,regulate
R6084 T7838 T7832 themeOf transcription,regulate
R6085 T7839 T7838 themeOf perforin,transcription
R6086 T7840 T7837 themeOf IFN-γ,transcription
R6087 T7841 T7836 themeOf granzyme B,transcription
R6088 T7842 T7846 themeOf Eomes,bound
R6089 T7842 T7849 themeOf Eomes,bound
R6090 T7842 T7847 themeOf Eomes,bound
R6091 T7842 T7854 themeOf Eomes,associated
R6092 T7843 T7845 themeOf Runx3,bound
R6093 T7843 T7848 themeOf Runx3,bound
R6094 T7843 T7844 themeOf Runx3,bound
R6095 T7843 T7855 themeOf Runx3,associated
R6096 T7850 T7846 themeOf regulatory regions,bound
R6097 T7850 T7851 partOf regulatory regions,Prf1
R6098 T7850 T7849 themeOf regulatory regions,bound
R6099 T7850 T7852 partOf regulatory regions,Ifng
R6100 T7850 T7847 themeOf regulatory regions,bound
R6101 T7850 T7853 partOf regulatory regions,Gzmb
R6102 T7850 T7845 themeOf regulatory regions,bound
R6103 T7850 T7848 themeOf regulatory regions,bound
R6104 T7850 T7844 themeOf regulatory regions,bound
R6105 T7856 T7858 themeOf Runx3,bound
R6106 T7856 T7857 themeOf Runx3,bound
R6107 T7861 T7858 themeOf transcription start sites,bound
R6108 T7861 T7859 partOf transcription start sites,Prf1
R6109 T7861 T7857 themeOf transcription start sites,bound
R6110 T7861 T7860 partOf transcription start sites,Gzmb
R6111 T7866 T7872 themeOf Eomes,that
R6112 T7866 T7877 themeOf Eomes,that
R6113 T7866 T7868 themeOf Eomes,bound
R6114 T7866 T7867 themeOf Eomes,bound
R6115 T7870 T7868 themeOf TSS,bound
R6116 T7870 T7869 partOf TSS,Prf1
R6117 T7871 T7867 themeOf −1 kb enhancer,bound
R6118 T7871 T7869 partOf −1 kb enhancer,Prf1
R6119 T7873 T7872 themeOf promoter,that
R6120 T7873 T7874 partOf promoter,Il2rb
R6121 T7873 T7875 themeOf promoter,target
R6122 T7876 T7875 themeOf Eomes,target
R6123 T7879 T7877 themeOf TSS,that
R6124 T7879 T7878 partOf TSS,Ifng
R6125 T7879 T7880 themeOf TSS,target
R6126 T7882 T7883 causeOf Runx3,induction
R6127 T7884 T7883 themeOf Eomes,induction
R6128 T7887 T7886 themeOf Runx3,expressed
R6129 T7888 T7885 themeOf Eo-VP16,expressed
R6130 T7901 T7905 causeOf Runx3,restored
R6131 T7901 T7904 causeOf Runx3,restored
R6132 T7901 T7903 causeOf Runx3,restored
R6133 T7901 T7902 causeOf Runx3,restored
R6134 T7906 T7904 themeOf expression,restored
R6135 T7907 T7905 themeOf expression,restored
R6136 T7908 T7903 themeOf expression,restored
R6137 T7909 T7902 themeOf expression,restored
R6138 T7910 T7907 themeOf Eomes,expression
R6139 T7911 T7906 themeOf perforin,expression
R6140 T7912 T7908 themeOf granzyme B,expression
R6141 T7913 T7909 themeOf IFN-γ,expression
R6142 T7916 T7915 themeOf Runx1,up-regulation
R6143 T7916 T7917 themeOf Runx1,suppressed
R6144 T7918 T7917 causeOf Runx3,suppressed
R6145 T7919 T7920 themeOf Runx1,repression
R6146 T7921 T7920 causeOf Runx3,repression
R6147 T7922 T7923 causeOf Eo-VP16,up-regulate
R6148 T7922 T7926 themeOf Eo-VP16,expressed
R6149 T7922 T7928 causeOf Eo-VP16,restored
R6150 T7924 T7925 themeOf perforin,expression
R6151 T7925 T7923 themeOf expression,up-regulate
R6152 T7929 T7928 themeOf induce,restored
R6153 T7930 T7931 themeOf IFN-γ,expression
R6154 T7931 T7929 themeOf expression,induce
R6155 T7932 T7933 themeOf perforin,expression
R6156 T7933 T7934 themeOf expression,requires
R6157 T7933 T7935 themeOf expression,requires
R6158 T7936 T7934 causeOf Runx3,requires
R6159 T7936 T7939 causeOf Runx3,defect
R6160 T7936 T7940 causeOf Runx3,defect
R6161 T7937 T7935 causeOf Eomes,requires
R6162 T7937 T7941 causeOf Eomes,defect
R6163 T7937 T7938 causeOf Eomes,defect
R6164 T7942 T7945 themeOf perforin,expression
R6165 T7943 T7944 themeOf granzyme B,expression
R6166 T7944 T7940 themeOf expression,defect
R6167 T7944 T7938 themeOf expression,defect
R6168 T7945 T7939 themeOf expression,defect
R6169 T7945 T7941 themeOf expression,defect
R6170 T7952 T7956 themeOf activation,defective
R6171 T7953 T7957 themeOf activation,defective
R6172 T7954 T7953 themeOf perforin,activation
R6173 T7955 T7952 themeOf granzyme B,activation
R15999 T20930 T20923 themeOf expression,induces
R15540 T20135 T20141 themeOf Runx3,expression
R15541 T20136 T20142 themeOf Eomes,expression
R15542 T20137 T20139 themeOf T-bet,expression
R15543 T20138 T20140 themeOf perforin,expression
R15544 T20147 T20148 themeOf Prf1,mRNA expression
R15545 T20157 T20153 themeOf granzyme B,Expression
R15546 T20158 T20154 themeOf IFN-γ,Expression
R15547 T20159 T20156 themeOf TNF,Expression
R15548 T20160 T20155 themeOf IL-2,Expression
R15549 T20168 T20167 themeOf Runx3,binding
R15550 T20169 T20166 themeOf Eomes,binding
R15551 T20170 T20167 themeOf Prf1,binding
R15552 T20170 T20166 themeOf Prf1,binding
R15965 T20876 T20880 causeOf Runx3,controls
R15971 T20883 T20885 themeOf granzyme B,expression
R15972 T20884 T20888 themeOf IFN-γ,expression
R15974 T20886 T20879 themeOf expression,controls
R15976 T20888 T20880 themeOf expression,controls
R15977 T20894 T20893 equivalentTo Eo-VP16,Eomes-VP16
R15978 T20899 T20898 themeOf Eomes-VP16,Overexpression
R15979 T20904 T20903 themeOf granzyme B,Expression
R15980 T20905 T20902 themeOf IFN-γ,Expression
R15981 T20906 T20907 themeOf granzyme B,staining
R15982 T20910 T20911 themeOf T-bet,induced
R15983 T20910 T20912 causeOf T-bet,essential
R15984 T20913 T20914 themeOf IFN-γ,expression
R15985 T20914 T20912 themeOf expression,essential
R15986 T20915 T20916 themeOf Runx3,present
R15987 T20915 T20918 causeOf Runx3,represses
R15988 T20915 T20923 causeOf Runx3,induces
R15992 T20919 T20918 themeOf Runx1,represses
R15993 T20924 T20930 themeOf Eomes,expression
R15966 T20876 T20879 causeOf Runx3,controls
R15967 T20876 T20878 causeOf Runx3,controls
R15968 T20876 T20877 causeOf Runx3,controls
R15969 T20881 T20886 themeOf Eomes,expression
R15970 T20882 T20887 themeOf perforin,expression
R15973 T20885 T20877 themeOf expression,controls
R15975 T20887 T20878 themeOf expression,controls
R15989 T20915 T20921 causeOf Runx3,induces
R15990 T20915 T20922 causeOf Runx3,induces
R15991 T20915 T20920 causeOf Runx3,induces
R15994 T20925 T20931 themeOf perforin,expression
R15995 T20926 T20928 themeOf granzyme B,expression
R15996 T20927 T20929 themeOf IFN-γ,expression
R15997 T20928 T20922 themeOf expression,induces
R15998 T20929 T20920 themeOf expression,induces
R16000 T20931 T20921 themeOf expression,induces
R16001 T20932 T20933 causeOf Eomes,participate
R16002 T20934 T20935 themeOf IFN-γ,expression
R16003 T20935 T20933 themeOf expression,participate
R16004 T20936 T20940 causeOf Runx3,activate
R16005 T20937 T20939 causeOf Eomes,activate
R16006 T20938 T20941 causeOf T-bet,activate
R16007 T20942 T20943 themeOf perforin,expression
R16008 T20943 T20940 themeOf expression,activate
R16009 T20943 T20939 themeOf expression,activate
R16010 T20943 T20941 themeOf expression,activate
R16011 T20946 T20947 themeOf T-bet,deficiency
R16012 T20947 T20944 causeOf deficiency,effect
R16013 T20947 T20945 causeOf deficiency,effect
R16014 T20948 T20950 themeOf Gzmb,expression
R16015 T20949 T20951 themeOf granzyme B,expression
R16016 T20950 T20944 themeOf expression,effect
R16017 T20951 T20945 themeOf expression,effect
R6027 T7753 T7754 themeOf Runx3,expressed
R6028 T7769 T7766 themeOf perforin,expression
R6029 T7770 T7768 themeOf granzyme B,expression
R6030 T7771 T7767 themeOf IFN-γ,expression
R6031 T7772 T7773 themeOf perforin,expression
R6032 T7773 T7774 themeOf expression,undetectable
R6033 T7777 T7778 themeOf Eomes,expression
R6034 T7779 T7780 themeOf T-bet,expression
R6035 T7780 T7781 themeOf expression,unimpaired
R6036 T7782 T7784 causeOf Runx3,required
R6040 T7787 T7783 themeOf production,required
R6025 T7750 T7751 causeOf Runx3,induction

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T9877 0-5 Q13761 denotes Runx3
T9878 97-102 O95936 denotes Eomes
T9879 111-116 Q13761 denotes Runx3
T9880 151-154 P01732 denotes CD8
T9881 151-154 P10966 denotes CD8
T9882 184-189 Q9UL17 denotes T-bet
T9883 190-195 Q13761 denotes Runx3
T9884 231-234 P01730 denotes CD4
T9885 274-279 Q13761 denotes Runx3
T9886 325-328 P01732 denotes CD8
T9887 325-328 P10966 denotes CD8
T9888 343-348 Q13761 denotes Runx3
T9889 405-410 Q13761 denotes Runx3
T9890 458-461 P01732 denotes CD8
T9891 458-461 P10966 denotes CD8
T9892 575-580 Q13761 denotes Runx3
T9893 584-587 P01732 denotes CD8
T9894 584-587 P10966 denotes CD8
T9895 701-709 P14222 denotes perforin
T9896 711-721 P10144 denotes granzyme B
T9897 727-732 P01579 denotes IFN-γ
T9898 769-777 P14222 denotes perforin
T9899 839-844 Q13761 denotes Runx3
T9900 895-900 Q13761 denotes Runx3
T9901 935-940 O95936 denotes Eomes
T9902 966-971 Q9UL17 denotes T-bet
T9903 1023-1028 Q13761 denotes Runx3
T9904 1068-1073 P01579 denotes IFN-γ
T9905 1083-1086 P01375 denotes TNF
T9906 1090-1094 P60568 denotes IL-2
T9907 1099-1102 P01732 denotes CD8
T9908 1099-1102 P10966 denotes CD8
T9909 2388-2393 Q9UL17 denotes T-bet
T9910 2428-2433 Q13761 denotes Runx3
T9911 2447-2452 Q9UL17 denotes T-bet
T9912 2457-2462 Q13761 denotes Runx3
T9913 2483-2488 P01579 denotes IFN-γ
T9914 2501-2505 P05112 denotes IL-4
T9915 2590-2595 Q13761 denotes Runx3
T9916 2619-2624 O95936 denotes Eomes
T9917 2667-2672 O95936 denotes Eomes
T9918 2704-2712 P14222 denotes perforin
T9919 2760-2767 O95936 denotes Eo-VP16
T9920 2784-2789 Q9UL17 denotes T-bet
T9921 2835-2843 P14222 denotes perforin
T9922 2848-2853 P01579 denotes IFN-γ
T9923 3011-3015 Q13950 denotes Runx
T9924 3011-3015 Q01196 denotes Runx
T9925 3011-3015 Q13761 denotes Runx
T9926 3080-3085 Q13761 denotes Runx3
T9927 3111-3116 O95936 denotes Eomes
T9928 3149-3154 O95936 denotes Eomes
T9929 3209-3217 P14222 denotes perforin
T9930 3219-3224 P01579 denotes IFN-γ
T9931 3230-3240 P10144 denotes granzyme B
T9932 3334-3339 O95936 denotes Eomes
T9933 3344-3349 Q13761 denotes Runx3
T9934 3382-3386 P14222 denotes Prf1
T9935 3388-3392 P01579 denotes Ifng
T9936 3398-3402 P10144 denotes Gzmb
T9937 3499-3504 Q13761 denotes Runx3
T9938 3518-3522 P14222 denotes Prf1
T9939 3527-3531 P10144 denotes Gzmb
T9940 3576-3580 P60568 denotes IL-2
T9941 3627-3631 P14222 denotes Prf1
T9942 3707-3711 P14222 denotes Prf1
T9943 3731-3735 P01579 denotes Ifng
T9944 3853-3857 P01579 denotes Ifng
T9945 3898-3903 O95936 denotes Eomes
T9946 3927-3931 P14222 denotes Prf1
T9947 4078-4083 O95936 denotes Eomes
T9948 4128-4132 P01579 denotes Ifng
T9949 4187-4190 P01732 denotes CD8
T9950 4187-4190 P10966 denotes CD8
T9951 4238-4243 Q13761 denotes Runx3
T9952 4317-4322 O95936 denotes Eomes
T9953 4350-4355 Q13761 denotes Runx3
T9954 4360-4367 O95936 denotes Eo-VP16
T9955 4371-4374 P10966 denotes CD8
T9956 4371-4374 P01732 denotes CD8
T9957 4389-4394 Q13761 denotes Runx3
T9958 4437-4440 P10966 denotes CD8
T9959 4437-4440 P01732 denotes CD8
T9960 4506-4511 Q13761 denotes Runx3
T9961 4515-4518 P01732 denotes CD8
T9962 4515-4518 P10966 denotes CD8
T9963 4519-4522 P01730 denotes CD4
T9964 4531-4534 P01732 denotes CD8
T9965 4531-4534 P10966 denotes CD8
T9966 4535-4538 P01730 denotes CD4
T9967 4592-4597 Q13761 denotes Runx3
T9968 4601-4604 P10966 denotes CD8
T9969 4601-4604 P01732 denotes CD8
T9970 4705-4710 Q13761 denotes Runx3
T9971 4714-4717 P10966 denotes CD8
T9972 4714-4717 P01732 denotes CD8
T9973 4732-4737 Q13761 denotes Runx3
T9974 4761-4766 O95936 denotes Eomes
T9975 4778-4786 P14222 denotes perforin
T9976 4788-4798 P10144 denotes granzyme B
T9977 4804-4809 P01579 denotes IFN-γ
T9978 4842-4847 Q13761 denotes Runx3
T9979 4898-4903 Q01196 denotes Runx1
T9980 4951-4956 Q13761 denotes Runx3
T9981 4974-4979 Q01196 denotes Runx1
T9982 5009-5014 Q13761 denotes Runx3
T9983 5025-5032 O95936 denotes Eo-VP16
T9984 5053-5061 P14222 denotes perforin
T9985 5091-5096 Q13761 denotes Runx3
T9986 5154-5159 P01579 denotes IFN-γ
T9987 5248-5256 P14222 denotes perforin
T9988 5277-5282 Q13761 denotes Runx3
T9989 5287-5292 O95936 denotes Eomes
T9990 6998-7006 P14222 denotes perforin
T9991 7011-7021 P10144 denotes granzyme B
T9992 7034-7039 Q13761 denotes Runx3
T9993 7043-7046 P10966 denotes CD8
T9994 7043-7046 P01732 denotes CD8
T9995 7153-7158 Q13761 denotes Runx3
T9996 7162-7165 P10966 denotes CD8
T9997 7162-7165 P01732 denotes CD8
T9998 7271-7274 P01732 denotes CD8
T9999 7271-7274 P10966 denotes CD8
T10000 7312-7317 Q13761 denotes Runx3
T10001 7438-7446 P14222 denotes perforin
T10002 7447-7457 P10144 denotes granzyme B
T10003 7484-7489 Q13761 denotes Runx3
T10004 7493-7496 P10966 denotes CD8
T10005 7493-7496 P01732 denotes CD8
T10006 7656-7666 P48023 denotes Fas ligand
T20425 1169-1174 Q13761 denotes Runx3
T20426 1232-1237 Q13761 denotes Runx3
T20427 1239-1244 O95936 denotes Eomes
T20428 1246-1251 Q9UL17 denotes T-bet
T20429 1257-1265 P14222 denotes perforin
T20430 1280-1285 Q13761 denotes Runx3
T20431 1296-1301 Q13761 denotes Runx3
T20432 1305-1308 P01732 denotes CD8
T20433 1305-1308 P10966 denotes CD8
T20434 1345-1352 P60709 denotes β-Actin
T20435 1414-1418 P14222 denotes Prf1
T20436 1438-1443 Q13761 denotes Runx3
T20437 1454-1459 Q13761 denotes Runx3
T20438 1463-1466 P10966 denotes CD8
T20439 1463-1466 P01732 denotes CD8
T20440 1500-1507 P60709 denotes β–Actin
T20441 1557-1567 P10144 denotes granzyme B
T20442 1569-1574 P01579 denotes IFN-γ
T20443 1576-1579 P01375 denotes TNF
T20444 1585-1589 P60568 denotes IL-2
T20445 1623-1628 Q13761 denotes Runx3
T20446 1639-1644 Q13761 denotes Runx3
T20447 1648-1651 P01732 denotes CD8
T20448 1648-1651 P10966 denotes CD8
T20449 1725-1735 P10144 denotes granzyme B
T20450 1747-1750 Q9U6Y4 denotes GFP
T20451 1868-1873 Q13761 denotes Runx3
T20452 1878-1883 O95936 denotes Eomes
T20453 1891-1895 P14222 denotes Prf1
T20454 2132-2135 P10966 denotes CD8
T20455 2132-2135 P01732 denotes CD8
T20456 2222-2226 P14222 denotes Prf1
T20457 2245-2250 Q13761 denotes Runx3
T20458 2273-2278 O95936 denotes Eomes
T21567 5304-5309 Q13761 denotes Runx3
T21568 5319-5324 O95936 denotes Eomes
T21569 5326-5334 P14222 denotes perforin
T21570 5336-5346 P10144 denotes granzyme B
T21571 5352-5357 P01579 denotes IFN-γ
T21572 5387-5392 Q13761 denotes Runx3
T21573 5399-5404 Q13761 denotes Runx3
T21574 5408-5411 P01732 denotes CD8
T21575 5408-5411 P10966 denotes CD8
T21576 5491-5494 Q9U6Y4 denotes GFP
T21577 5505-5508 Q9U6Y4 denotes GFP
T21578 5527-5532 O95936 denotes Eomes
T21579 5539-5546 O95936 denotes Eo-VP16
T21580 5551-5554 P01106 denotes Myc
T21581 5555-5560 Q13761 denotes Runx3
T21582 5562-5567 Q13761 denotes Runx3
T21583 5663-5666 Q9U6Y4 denotes GFP
T21584 5794-5799 O95936 denotes Eomes
T21585 5833-5838 O95936 denotes Eomes
T21586 5975-5985 P10144 denotes granzyme B
T21587 5990-5995 P01579 denotes IFN-γ
T21588 6218-6228 P10144 denotes granzyme B
T21589 6336-6339 Q9U6Y4 denotes GFP
T21590 6479-6484 Q13761 denotes Runx3
T21591 6504-6509 Q9UL17 denotes T-bet
T21592 6563-6568 P01579 denotes IFN-γ
T21593 6581-6586 Q13761 denotes Runx3
T21594 6607-6610 P01732 denotes CD8
T21595 6607-6610 P10966 denotes CD8
T21596 6634-6639 Q01196 denotes Runx1
T21597 6652-6657 O95936 denotes Eomes
T21598 6659-6667 P14222 denotes perforin
T21599 6669-6679 P10144 denotes granzyme B
T21600 6685-6690 P01579 denotes IFN-γ
T21601 6703-6708 O95936 denotes Eomes
T21602 6744-6749 P01579 denotes IFN-γ
T21603 6770-6775 Q13761 denotes Runx3
T21604 6780-6785 O95936 denotes Eomes
T21605 6795-6800 Q9UL17 denotes T-bet
T21606 6828-6836 P14222 denotes perforin
T21607 6897-6902 Q9UL17 denotes T-bet
T21608 6917-6921 P10144 denotes Gzmb
T21609 6935-6945 P10144 denotes granzyme B

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T7585 0-5 Protein denotes Runx3
T7586 84-93 Positive_regulation denotes induction
T7587 97-102 Protein denotes Eomes true
T7588 111-116 Protein denotes Runx3 true
T7589 127-136 Gene_expression denotes expressed true
T7590 151-154 Protein denotes CD8
T7591 184-189 Protein denotes T-bet true
T7592 190-195 Protein denotes Runx3 true
T7593 231-234 Protein denotes CD4
T7594 274-279 Protein denotes Runx3 true
T7595 325-328 Protein denotes CD8
T7596 343-348 Protein denotes Runx3
T7597 405-410 Protein denotes Runx3
T7598 458-461 Protein denotes CD8
T7599 575-580 Protein denotes Runx3
T7600 584-587 Protein denotes CD8
T7601 687-697 Gene_expression denotes expression
T7602 701-709 Protein denotes perforin
T7603 711-721 Protein denotes granzyme B
T7604 727-732 Protein denotes IFN-γ
T7605 769-777 Protein denotes perforin
T7606 795-805 Gene_expression denotes expression
T7607 839-844 Protein denotes Runx3 true
T7608 895-900 Protein denotes Runx3
T7609 935-940 Protein denotes Eomes
T7610 941-951 Gene_expression denotes expression
T7611 966-971 Protein denotes T-bet
T7612 972-982 Gene_expression denotes expression
T7613 987-997 Negative_regulation denotes unimpaired
T7614 1023-1028 Protein denotes Runx3
T7615 1033-1041 Positive_regulation denotes required
T7616 1054-1064 Gene_expression denotes production
T7617 1068-1073 Protein denotes IFN-γ
T7618 1083-1086 Protein denotes TNF
T7619 1090-1094 Protein denotes IL-2 true
T7620 1099-1102 Protein denotes CD8
T7621 2388-2393 Protein denotes T-bet
T7622 2397-2409 Positive_regulation denotes up-regulated
T7623 2420-2427 Positive_regulation denotes induces
T7624 2428-2433 Protein denotes Runx3
T7625 2447-2452 Protein denotes T-bet
T7626 2457-2462 Protein denotes Runx3
T7627 2476-2482 Positive_regulation denotes induce
T7628 2483-2488 Protein denotes IFN-γ
T7629 2493-2500 Negative_regulation denotes silence
T7630 2501-2505 Protein denotes IL-4 true
T7631 2590-2595 Protein denotes Runx3 true
T7632 2605-2614 Positive_regulation denotes necessary true
T7633 2619-2624 Protein denotes Eomes true
T7634 2625-2634 Positive_regulation denotes induction true
T7635 2667-2672 Protein denotes Eomes true
T7636 2673-2683 Gene_expression denotes expression
T7637 2704-2712 Protein denotes perforin
T7638 2713-2723 Gene_expression denotes expression
T7639 2742-2756 Positive_regulation denotes overexpression
T7640 2760-2767 Protein denotes Eo-VP16
T7641 2784-2789 Protein denotes T-bet
T7642 2790-2799 Negative_regulation denotes deficient
T7643 2818-2826 Positive_regulation denotes increase
T7644 2835-2843 Protein denotes perforin
T7645 2848-2853 Protein denotes IFN-γ
T7646 2854-2864 Gene_expression denotes expression
T7647 3080-3085 Protein denotes Runx3
T7648 3097-3106 Positive_regulation denotes necessary
T7649 3111-3116 Protein denotes Eomes
T7650 3117-3126 Positive_regulation denotes induction
T7651 3149-3154 Protein denotes Eomes
T7652 3158-3166 Regulation denotes regulate
T7653 3167-3180 Transcription denotes transcription
T7654 3209-3217 Protein denotes perforin
T7655 3219-3224 Protein denotes IFN-γ
T7656 3230-3240 Protein denotes granzyme B
T7657 3334-3339 Protein denotes Eomes
T7658 3344-3349 Protein denotes Runx3
T7659 3350-3355 Binding denotes bound
T7660 3356-3374 Entity denotes regulatory regions true
T7661 3382-3386 Protein denotes Prf1
T7662 3388-3392 Protein denotes Ifng
T7663 3398-3402 Protein denotes Gzmb
T7664 3499-3504 Protein denotes Runx3
T7665 3505-3510 Binding denotes bound
T7666 3518-3522 Protein denotes Prf1
T7667 3527-3531 Protein denotes Gzmb true
T7668 3532-3557 Entity denotes transcription start sites true
T7669 3627-3631 Protein denotes Prf1 true
T7670 3707-3711 Protein denotes Prf1
T7671 3731-3735 Protein denotes Ifng true
T7672 3853-3857 Protein denotes Ifng true
T7673 3898-3903 Protein denotes Eomes
T7674 3904-3909 Binding denotes bound true
T7675 3927-3931 Protein denotes Prf1
T7676 3932-3935 Entity denotes TSS
T7677 3944-3958 Entity denotes −1 kb enhancer
T7678 3965-3972 Binding denotes binding
T7679 4025-4033 Entity denotes promoter
T7680 4041-4046 Protein denotes Il2rb
T7681 4068-4074 Binding denotes target
T7682 4078-4083 Protein denotes Eomes
T7683 4128-4132 Protein denotes Ifng
T7684 4133-4136 Entity denotes TSS
T7685 4187-4190 Protein denotes CD8
T7686 4238-4243 Protein denotes Runx3
T7687 4304-4313 Positive_regulation denotes induction
T7688 4317-4322 Protein denotes Eomes
T7689 4340-4349 Gene_expression denotes expressed
T7690 4350-4355 Protein denotes Runx3
T7691 4360-4367 Protein denotes Eo-VP16
T7692 4371-4374 Protein denotes CD8
T7693 4389-4394 Protein denotes Runx3
T7694 4437-4440 Protein denotes CD8
T7695 4506-4511 Protein denotes Runx3
T7696 4515-4518 Protein denotes CD8
T7697 4519-4522 Protein denotes CD4
T7698 4531-4534 Protein denotes CD8
T7699 4535-4538 Protein denotes CD4
T7700 4592-4597 Protein denotes Runx3
T7701 4601-4604 Protein denotes CD8
T7702 4705-4710 Protein denotes Runx3
T7703 4714-4717 Protein denotes CD8
T7704 4732-4737 Protein denotes Runx3
T7705 4747-4757 Gene_expression denotes expression
T7706 4761-4766 Protein denotes Eomes
T7707 4778-4786 Protein denotes perforin
T7708 4788-4798 Protein denotes granzyme B
T7709 4804-4809 Protein denotes IFN-γ
T7710 4842-4847 Protein denotes Runx3
T7711 4881-4894 Positive_regulation denotes up-regulation
T7712 4898-4903 Protein denotes Runx1
T7713 4915-4925 Negative_regulation denotes suppressed
T7714 4951-4956 Protein denotes Runx3
T7715 4974-4979 Protein denotes Runx1
T7716 4995-5005 Negative_regulation denotes repression
T7717 5009-5014 Protein denotes Runx3
T7718 5025-5032 Protein denotes Eo-VP16
T7719 5041-5052 Positive_regulation denotes up-regulate
T7720 5053-5061 Protein denotes perforin
T7721 5062-5072 Gene_expression denotes expression
T7722 5078-5087 Gene_expression denotes expressed
T7723 5091-5096 Protein denotes Runx3
T7724 5147-5153 Positive_regulation denotes induce
T7725 5154-5159 Protein denotes IFN-γ
T7726 5160-5170 Gene_expression denotes expression
T7727 5248-5256 Protein denotes perforin
T7728 5257-5267 Gene_expression denotes expression
T7729 5268-5276 Positive_regulation denotes requires
T7730 5277-5282 Protein denotes Runx3
T7731 5287-5292 Protein denotes Eomes
T7732 6988-6994 Negative_regulation denotes defect
T7733 6998-7006 Protein denotes perforin
T7734 7011-7021 Protein denotes granzyme B
T7735 7022-7032 Gene_expression denotes expression
T7736 7034-7039 Protein denotes Runx3
T7737 7043-7046 Protein denotes CD8
T7738 7153-7158 Protein denotes Runx3
T7739 7162-7165 Protein denotes CD8
T7740 7271-7274 Protein denotes CD8
T7741 7312-7317 Protein denotes Runx3
T7742 7420-7430 Positive_regulation denotes activation
T7743 7438-7446 Protein denotes perforin
T7744 7447-7457 Protein denotes granzyme B
T7745 7471-7480 Negative_regulation denotes defective
T7746 7484-7489 Protein denotes Runx3
T7747 7493-7496 Protein denotes CD8
T7748 7652-7655 Protein denotes Fas
T7749 7656-7666 Protein denotes Fas ligand
T20100 1169-1174 Protein denotes Runx3 true
T20101 1232-1237 Protein denotes Runx3 true
T20102 1239-1244 Protein denotes Eomes true
T20103 1246-1251 Protein denotes T-bet true
T20104 1257-1265 Protein denotes perforin true
T20105 1266-1276 Gene_expression denotes expression true
T20106 1280-1285 Protein denotes Runx3 true
T20107 1296-1301 Protein denotes Runx3 true
T20108 1305-1308 Protein denotes CD8 true
T20109 1345-1352 Protein denotes β-Actin true
T20110 1414-1418 Protein denotes Prf1 true
T20111 1419-1434 Transcription denotes mRNA expression
T20112 1438-1443 Protein denotes Runx3
T20113 1454-1459 Protein denotes Runx3
T20114 1463-1466 Protein denotes CD8
T20115 1500-1507 Protein denotes β–Actin
T20116 1543-1553 Gene_expression denotes Expression
T20117 1557-1567 Protein denotes granzyme B
T20118 1569-1574 Protein denotes IFN-γ
T20119 1576-1579 Protein denotes TNF
T20120 1585-1589 Protein denotes IL-2
T20121 1623-1628 Protein denotes Runx3
T20122 1639-1644 Protein denotes Runx3
T20123 1648-1651 Protein denotes CD8
T20124 1725-1735 Protein denotes granzyme B
T20125 1747-1750 Protein denotes GFP
T20126 1846-1853 Binding denotes binding
T20127 1868-1873 Protein denotes Runx3
T20128 1878-1883 Protein denotes Eomes
T20129 1891-1895 Protein denotes Prf1
T20130 2132-2135 Protein denotes CD8
T20131 2222-2226 Protein denotes Prf1
T20132 2245-2250 Protein denotes Runx3
T20133 2273-2278 Protein denotes Eomes
T20820 5304-5309 Protein denotes Runx3
T20821 5310-5318 Regulation denotes controls
T20822 5319-5324 Protein denotes Eomes
T20823 5326-5334 Protein denotes perforin
T20824 5336-5346 Protein denotes granzyme B
T20825 5352-5357 Protein denotes IFN-γ
T20826 5358-5368 Gene_expression denotes expression
T20827 5387-5392 Protein denotes Runx3
T20828 5399-5404 Protein denotes Runx3
T20829 5408-5411 Protein denotes CD8 true
T20830 5491-5494 Protein denotes GFP true
T20831 5527-5537 Protein denotes Eomes-VP16 true
T20832 5539-5546 Protein denotes Eo-VP16
T20833 5551-5554 Protein denotes Myc
T20834 5555-5560 Protein denotes Runx3
T20835 5562-5567 Protein denotes Runx3
T20836 5776-5790 Positive_regulation denotes Overexpression
T20837 5794-5804 Protein denotes Eomes-VP16
T20838 5833-5838 Protein denotes Eomes
T20839 5928-5932 Protein denotes VP16
T20840 5961-5971 Gene_expression denotes Expression
T20841 5975-5985 Protein denotes granzyme B
T20842 5990-5995 Protein denotes IFN-γ
T20843 6218-6228 Protein denotes granzyme B
T20844 6336-6339 Protein denotes GFP
T20845 6479-6484 Protein denotes Runx3 true
T20846 6504-6509 Protein denotes T-bet
T20847 6513-6520 Positive_regulation denotes induced true
T20848 6543-6552 Positive_regulation denotes essential
T20849 6563-6568 Protein denotes IFN-γ true
T20850 6569-6579 Gene_expression denotes expression true true
T20851 6581-6586 Protein denotes Runx3
T20852 6607-6610 Protein denotes CD8
T20853 6624-6633 Negative_regulation denotes represses
T20854 6634-6639 Protein denotes Runx1
T20855 6644-6651 Positive_regulation denotes induces true
T20856 6652-6657 Protein denotes Eomes
T20857 6659-6667 Protein denotes perforin
T20858 6669-6679 Protein denotes granzyme B
T20859 6685-6690 Protein denotes IFN-γ
T20860 6691-6701 Gene_expression denotes expression
T20861 6703-6708 Protein denotes Eomes
T20862 6728-6738 Positive_regulation denotes sustaining
T20863 6744-6749 Protein denotes IFN-γ
T20864 6750-6760 Gene_expression denotes expression
T20865 6770-6775 Protein denotes Runx3
T20866 6780-6785 Protein denotes Eomes
T20867 6795-6800 Protein denotes T-bet
T20868 6819-6827 Positive_regulation denotes activate
T20869 6828-6836 Protein denotes perforin
T20870 6837-6847 Gene_expression denotes expression
T20871 6897-6902 Protein denotes T-bet
T20872 6903-6913 Negative_regulation denotes deficiency
T20873 6917-6921 Protein denotes Gzmb
T20874 6935-6945 Protein denotes granzyme B
T20875 6954-6964 Gene_expression denotes expression
R5933 T7587 T7586 themeOf Eomes,induction
R5934 T7588 T7589 themeOf Runx3,expressed
R5935 T7602 T7601 themeOf perforin,expression
R5936 T7603 T7601 themeOf granzyme B,expression
R5937 T7604 T7601 themeOf IFN-γ,expression
R5938 T7605 T7606 themeOf perforin,expression
R5939 T7609 T7610 themeOf Eomes,expression
R5940 T7611 T7612 themeOf T-bet,expression
R5941 T7612 T7613 themeOf expression,unimpaired
R5942 T7614 T7615 causeOf Runx3,required
R5943 T7616 T7615 themeOf production,required
R5944 T7617 T7616 themeOf IFN-γ,production
R5945 T7618 T7616 themeOf TNF,production
R5946 T7619 T7616 themeOf IL-2,production
R5947 T7621 T7622 themeOf T-bet,up-regulated
R5948 T7624 T7623 themeOf Runx3,induces
R5949 T7625 T7627 causeOf T-bet,induce
R5950 T7625 T7629 causeOf T-bet,silence
R5951 T7626 T7627 causeOf Runx3,induce
R5952 T7626 T7629 causeOf Runx3,silence
R5953 T7628 T7627 themeOf IFN-γ,induce
R5954 T7630 T7629 themeOf IL-4,silence
R5955 T7631 T7632 causeOf Runx3,necessary
R5956 T7633 T7634 themeOf Eomes,induction
R5957 T7634 T7632 themeOf induction,necessary
R5958 T7635 T7636 themeOf Eomes,expression
R5959 T7637 T7638 themeOf perforin,expression
R5960 T7640 T7639 themeOf Eo-VP16,overexpression
R5961 T7641 T7642 themeOf T-bet,deficient
R5962 T7644 T7646 themeOf perforin,expression
R5963 T7645 T7646 themeOf IFN-γ,expression
R5964 T7646 T7643 themeOf expression,increase
R5965 T7647 T7648 causeOf Runx3,necessary
R5966 T7647 T7652 causeOf Runx3,regulate
R5967 T7649 T7650 themeOf Eomes,induction
R5968 T7650 T7648 themeOf induction,necessary
R5969 T7651 T7652 causeOf Eomes,regulate
R5970 T7653 T7652 themeOf transcription,regulate
R5971 T7654 T7653 themeOf perforin,transcription
R5972 T7655 T7653 themeOf IFN-γ,transcription
R5973 T7656 T7653 themeOf granzyme B,transcription
R5974 T7657 T7659 themeOf Eomes,bound
R5975 T7658 T7659 themeOf Runx3,bound
R5976 T7660 T7659 themeOf regulatory regions,bound
R5977 T7660 T7661 partOf regulatory regions,Prf1
R5978 T7660 T7662 partOf regulatory regions,Ifng
R5979 T7660 T7663 partOf regulatory regions,Gzmb
R5980 T7664 T7665 themeOf Runx3,bound
R5981 T7668 T7666 partOf transcription start sites,Prf1
R5982 T7668 T7667 partOf transcription start sites,Gzmb
R5983 T7668 T7665 themeOf transcription start sites,bound
R5984 T7673 T7674 themeOf Eomes,bound
R5985 T7676 T7674 themeOf TSS,bound
R5986 T7676 T7675 partOf TSS,Prf1
R5987 T7677 T7674 themeOf −1 kb enhancer,bound
R5988 T7677 T7675 partOf −1 kb enhancer,Prf1
R5989 T7679 T7682 partOf promoter,Eomes
R5990 T7679 T7681 themeOf promoter,target
R5991 T7679 T7680 partOf promoter,Il2rb
R5992 T7682 T7681 themeOf Eomes,target
R5993 T7684 T7683 partOf TSS,Ifng
R5994 T7686 T7687 causeOf Runx3,induction
R5995 T7688 T7687 themeOf Eomes,induction
R5996 T7690 T7689 themeOf Runx3,expressed
R5997 T7691 T7689 themeOf Eo-VP16,expressed
R5998 T7706 T7705 themeOf Eomes,expression
R5999 T7707 T7705 themeOf perforin,expression
R6000 T7708 T7705 themeOf granzyme B,expression
R6001 T7709 T7705 themeOf IFN-γ,expression
R6002 T7711 T7713 themeOf up-regulation,suppressed
R6003 T7712 T7711 themeOf Runx1,up-regulation
R6004 T7714 T7713 causeOf Runx3,suppressed
R6005 T7715 T7716 themeOf Runx1,repression
R6006 T7717 T7716 causeOf Runx3,repression
R6007 T7718 T7722 themeOf Eo-VP16,expressed
R6008 T7718 T7719 causeOf Eo-VP16,up-regulate
R6009 T7720 T7721 themeOf perforin,expression
R6010 T7721 T7719 themeOf expression,up-regulate
R6011 T7725 T7726 themeOf IFN-γ,expression
R6012 T7726 T7724 themeOf expression,induce
R6013 T7727 T7728 themeOf perforin,expression
R6014 T7728 T7729 themeOf expression,requires
R6015 T7730 T7729 causeOf Runx3,requires
R6016 T7731 T7729 causeOf Eomes,requires
R6017 T7733 T7735 themeOf perforin,expression
R6018 T7734 T7735 themeOf granzyme B,expression
R6019 T7735 T7732 themeOf expression,defect
R6020 T7742 T7745 themeOf activation,defective
R6021 T7743 T7742 themeOf perforin,activation
R6022 T7744 T7742 themeOf granzyme B,activation
R6023 T7748 T7745 causeOf Fas,defective
R6024 T7749 T7748 themeOf Fas ligand,Fas
R15528 T20101 T20105 themeOf Runx3,expression
R15529 T20102 T20105 themeOf Eomes,expression
R15530 T20103 T20105 themeOf T-bet,expression
R15531 T20104 T20105 themeOf perforin,expression
R15532 T20110 T20111 themeOf Prf1,mRNA expression
R15533 T20117 T20116 themeOf granzyme B,Expression
R15534 T20118 T20116 themeOf IFN-γ,Expression
R15535 T20119 T20116 themeOf TNF,Expression
R15536 T20120 T20116 themeOf IL-2,Expression
R15537 T20127 T20126 themeOf Runx3,binding
R15538 T20128 T20126 themeOf Eomes,binding
R15539 T20129 T20126 themeOf Prf1,binding
R15933 T20820 T20821 causeOf Runx3,controls
R15934 T20822 T20826 themeOf Eomes,expression
R15935 T20823 T20826 themeOf perforin,expression
R15936 T20824 T20826 themeOf granzyme B,expression
R15937 T20825 T20826 themeOf IFN-γ,expression
R15938 T20826 T20821 themeOf expression,controls
R15939 T20832 T20831 equivalentTo Eo-VP16,Eomes-VP16
R15940 T20837 T20836 themeOf Eomes-VP16,Overexpression
R15941 T20841 T20840 themeOf granzyme B,Expression
R15942 T20842 T20840 themeOf IFN-γ,Expression
R15943 T20846 T20848 causeOf T-bet,essential
R15944 T20846 T20847 themeOf T-bet,induced
R15945 T20849 T20850 themeOf IFN-γ,expression
R15946 T20850 T20848 themeOf expression,essential
R15947 T20854 T20855 causeOf Runx1,induces
R15948 T20856 T20860 themeOf Eomes,expression
R15949 T20857 T20860 themeOf perforin,expression
R15950 T20858 T20860 themeOf granzyme B,expression
R15951 T20859 T20860 themeOf IFN-γ,expression
R15952 T20860 T20855 themeOf expression,induces
R15953 T20861 T20862 causeOf Eomes,sustaining
R15954 T20861 T20868 causeOf Eomes,activate
R15955 T20863 T20864 themeOf IFN-γ,expression
R15956 T20864 T20862 themeOf expression,sustaining
R15957 T20865 T20868 causeOf Runx3,activate
R15958 T20866 T20868 causeOf Eomes,activate
R15959 T20867 T20868 causeOf T-bet,activate
R15960 T20869 T20870 themeOf perforin,expression
R15961 T20870 T20868 themeOf expression,activate
R15962 T20871 T20872 themeOf T-bet,deficiency
R15963 T20873 T20875 themeOf Gzmb,expression
R15964 T20874 T20875 themeOf granzyme B,expression