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PMC:2626671 / 104-1137 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T283 0-10 NN denotes Activation
T284 11-13 IN denotes of
T285 14-19 JJ denotes naive
T286 20-24 JJ denotes CD8+
T287 25-26 NN denotes T
T288 27-32 NN denotes cells
T289 33-37 IN denotes with
T290 38-45 NN denotes antigen
T291 46-53 VB denotes induces
T292 54-59 PRP-DOLLAR- denotes their
T293 60-75 NN denotes differentiation
T294 76-80 IN denotes into
T295 81-89 NN denotes effector
T296 90-99 JJ denotes cytolytic
T297 100-101 NN denotes T
T298 102-113 NN denotes lymphocytes
T299 114-115 -LRB- denotes (
T300 115-119 NN denotes CTLs
T301 119-120 -RRB- denotes )
T302 122-126 NN denotes CTLs
T303 127-131 VB denotes lyse
T304 132-140 JJ denotes infected
T305 141-143 CC denotes or
T306 144-152 JJ denotes aberrant
T307 153-159 NN denotes target
T308 160-165 NN denotes cells
T309 166-168 IN denotes by
T310 169-179 NN denotes exocytosis
T311 180-182 IN denotes of
T312 183-188 JJ denotes lytic
T313 189-197 NN denotes granules
T314 198-208 VB denotes containing
T315 209-212 DT denotes the
T316 213-225 JJ denotes pore-forming
T317 226-233 NN denotes protein
T318 234-242 NN denotes perforin
T319 243-246 CC denotes and
T320 247-248 DT denotes a
T321 249-255 NN denotes family
T322 256-258 IN denotes of
T323 259-268 NN denotes proteases
T324 269-275 VB denotes termed
T325 276-285 NN denotes granzymes
T326 287-289 PRP denotes We
T327 290-294 VB denotes show
T328 295-299 IN denotes that
T329 300-308 NN denotes effector
T330 309-312 NN denotes CTL
T331 313-328 NN denotes differentiation
T332 329-335 VB denotes occurs
T333 336-338 IN denotes in
T334 339-342 CD denotes two
T335 343-353 JJ denotes sequential
T336 354-360 NN denotes phases
T337 361-363 FW denotes in
T338 364-369 FW denotes vitro
T339 369-370 -COMMA- denotes ,
T340 371-384 VB denotes characterized
T341 385-387 IN denotes by
T342 388-393 JJ denotes early
T343 394-403 NN denotes induction
T344 404-406 IN denotes of
T345 407-412 NN denotes T-bet
T346 413-416 CC denotes and
T347 417-421 JJ denotes late
T348 422-431 NN denotes induction
T349 432-434 IN denotes of
T350 435-447 NN denotes Eomesodermin
T351 448-449 -LRB- denotes (
T352 449-454 NN denotes Eomes
T353 454-455 -RRB- denotes )
T354 455-456 -COMMA- denotes ,
T355 457-462 NN denotes T-box
T356 463-476 NN denotes transcription
T357 477-484 NN denotes factors
T358 485-489 WDT denotes that
T359 490-498 VB denotes regulate
T360 499-502 DT denotes the
T361 503-508 JJ denotes early
T362 509-512 CC denotes and
T363 513-517 JJ denotes late
T364 518-524 NN denotes phases
T365 525-527 IN denotes of
T366 528-538 NN denotes interferon
T367 539-540 -LRB- denotes (
T368 540-543 NN denotes IFN
T369 543-544 -RRB- denotes )
T370 545-546 NN denotes γ
T371 547-557 NN denotes expression
T372 557-558 -COMMA- denotes ,
T373 559-571 RB denotes respectively
T374 573-575 IN denotes In
T375 576-584 NN denotes addition
T376 584-585 -COMMA- denotes ,
T377 586-588 PRP denotes we
T378 589-600 VB denotes demonstrate
T379 601-602 DT denotes a
T380 603-611 JJ denotes critical
T381 612-616 NN denotes role
T382 617-620 IN denotes for
T383 621-624 DT denotes the
T384 625-638 NN denotes transcription
T385 639-645 NN denotes factor
T386 646-651 NN denotes Runx3
T387 652-654 IN denotes in
T388 655-658 NN denotes CTL
T389 659-674 NN denotes differentiation
T390 676-681 NN denotes Runx3
T391 682-691 VB denotes regulates
T392 692-697 NN denotes Eomes
T393 698-708 NN denotes expression
T394 709-711 RB denotes as
T395 712-716 RB denotes well
T396 717-719 IN denotes as
T397 720-730 NN denotes expression
T398 731-733 IN denotes of
T399 734-739 CD denotes three
T400 740-748 JJ denotes cardinal
T401 749-756 NN denotes markers
T402 757-759 IN denotes of
T403 760-763 DT denotes the
T404 764-772 NN denotes effector
T405 773-776 NN denotes CTL
T406 777-784 NN denotes program
T407 784-785 -COLON- denotes :
T408 786-791 NN denotes IFN-γ
T409 791-792 -COMMA- denotes ,
T410 793-801 NN denotes perforin
T411 801-802 -COMMA- denotes ,
T412 803-806 CC denotes and
T413 807-815 NN denotes granzyme
T414 816-818 NNP denotes B.
T415 819-822 PRP-DOLLAR- denotes Our
T416 823-827 NN denotes data
T417 828-833 VB denotes point
T418 834-836 TO denotes to
T419 837-840 DT denotes the
T420 841-850 NN denotes existence
T421 851-853 IN denotes of
T422 854-856 DT denotes an
T423 857-866 JJ denotes elaborate
T424 867-882 JJ denotes transcriptional
T425 883-890 NN denotes network
T426 891-893 IN denotes in
T427 894-899 WDT denotes which
T428 900-905 NN denotes Runx3
T429 906-915 RB denotes initially
T430 916-923 VB denotes induces
T431 924-927 CC denotes and
T432 928-932 RB denotes then
T433 933-943 VB denotes cooperates
T434 944-948 IN denotes with
T435 949-954 NN denotes T-box
T436 955-968 NN denotes transcription
T437 969-976 NN denotes factors
T438 977-979 TO denotes to
T439 980-988 VB denotes regulate
T440 989-993 NN denotes gene
T441 994-1007 NN denotes transcription
T442 1008-1010 IN denotes in
T443 1011-1026 VB denotes differentiating
T444 1027-1031 NN denotes CTLs
R215 T283 T284 arg1Of Activation,of
R216 T283 T289 arg1Of Activation,with
R217 T283 T291 arg1Of Activation,induces
R218 T288 T284 arg2Of cells,of
R219 T288 T285 arg1Of cells,naive
R220 T288 T286 arg1Of cells,CD8+
R221 T288 T287 arg1Of cells,T
R222 T290 T289 arg2Of antigen,with
R223 T293 T291 arg2Of differentiation,induces
R224 T293 T292 arg1Of differentiation,their
R225 T293 T294 arg1Of differentiation,into
R226 T298 T294 arg2Of lymphocytes,into
R227 T298 T295 arg1Of lymphocytes,effector
R228 T298 T296 arg1Of lymphocytes,cytolytic
R229 T298 T297 arg1Of lymphocytes,T
R230 T298 T299 arg1Of lymphocytes,(
R231 T300 T299 arg2Of CTLs,(
R232 T301 T299 arg3Of ),(
R233 T302 T303 arg1Of CTLs,lyse
R234 T303 T309 arg1Of lyse,by
R235 T304 T305 arg1Of infected,or
R236 T306 T305 arg2Of aberrant,or
R237 T308 T303 arg2Of cells,lyse
R238 T308 T304 arg1Of cells,infected
R239 T308 T306 arg1Of cells,aberrant
R240 T308 T307 arg1Of cells,target
R241 T310 T309 arg2Of exocytosis,by
R242 T310 T311 arg1Of exocytosis,of
R243 T313 T311 arg2Of granules,of
R244 T313 T312 arg1Of granules,lytic
R245 T313 T314 arg1Of granules,containing
R246 T318 T315 arg1Of perforin,the
R247 T318 T316 arg1Of perforin,pore-forming
R248 T318 T317 arg1Of perforin,protein
R249 T318 T319 arg1Of perforin,and
R250 T319 T314 arg2Of and,containing
R251 T321 T319 arg2Of family,and
R252 T321 T320 arg1Of family,a
R253 T321 T322 arg1Of family,of
R254 T323 T322 arg2Of proteases,of
R255 T323 T324 arg2Of proteases,termed
R256 T325 T324 arg3Of granzymes,termed
R257 T326 T327 arg1Of We,show
R258 T331 T329 arg1Of differentiation,effector
R259 T331 T330 arg1Of differentiation,CTL
R260 T331 T332 arg1Of differentiation,occurs
R261 T332 T327 arg2Of occurs,show
R262 T332 T328 arg1Of occurs,that
R263 T332 T333 arg1Of occurs,in
R264 T336 T334 arg1Of phases,two
R265 T336 T335 arg1Of phases,sequential
R266 T336 T338 arg1Of phases,vitro
R267 T336 T339 arg1Of phases,","
R268 T336 T340 arg2Of phases,characterized
R269 T336 T354 arg1Of phases,","
R270 T338 T337 arg1Of vitro,in
R271 T343 T340 arg1Of induction,characterized
R272 T343 T341 arg2Of induction,by
R273 T343 T342 arg1Of induction,early
R274 T343 T344 arg1Of induction,of
R275 T345 T346 arg1Of T-bet,and
R276 T347 T346 arg2Of late,and
R277 T348 T344 arg2Of induction,of
R278 T348 T345 arg1Of induction,T-bet
R279 T348 T347 arg1Of induction,late
R280 T348 T349 arg1Of induction,of
R281 T350 T349 arg2Of Eomesodermin,of
R282 T350 T351 arg1Of Eomesodermin,(
R283 T352 T351 arg2Of Eomes,(
R284 T353 T351 arg3Of ),(
R285 T354 T333 arg2Of ",",in
R286 T354 T358 arg1Of ",",that
R287 T354 T359 arg1Of ",",regulate
R288 T357 T354 arg2Of factors,","
R289 T357 T355 arg1Of factors,T-box
R290 T357 T356 arg1Of factors,transcription
R291 T359 T372 arg1Of regulate,","
R292 T359 T373 arg1Of regulate,respectively
R293 T361 T362 arg1Of early,and
R294 T363 T362 arg2Of late,and
R295 T364 T359 arg2Of phases,regulate
R296 T364 T360 arg1Of phases,the
R297 T364 T361 arg1Of phases,early
R298 T364 T363 arg1Of phases,late
R299 T364 T365 arg1Of phases,of
R300 T368 T367 arg2Of IFN,(
R301 T369 T367 arg3Of ),(
R302 T371 T365 arg2Of expression,of
R303 T371 T366 arg1Of expression,interferon
R304 T371 T367 arg1Of expression,(
R305 T371 T370 arg1Of expression,γ
R306 T375 T374 arg2Of addition,In
R307 T377 T378 arg1Of we,demonstrate
R308 T378 T374 arg1Of demonstrate,In
R309 T378 T376 arg1Of demonstrate,","
R310 T381 T378 arg2Of role,demonstrate
R311 T381 T379 arg1Of role,a
R312 T381 T380 arg1Of role,critical
R313 T381 T382 arg1Of role,for
R314 T381 T387 arg1Of role,in
R315 T386 T382 arg2Of Runx3,for
R316 T386 T383 arg1Of Runx3,the
R317 T386 T384 arg1Of Runx3,transcription
R318 T386 T385 arg1Of Runx3,factor
R319 T389 T387 arg2Of differentiation,in
R320 T389 T388 arg1Of differentiation,CTL
R321 T390 T391 arg1Of Runx3,regulates
R322 T393 T396 arg1Of expression,as
R323 T396 T391 arg2Of as,regulates
R324 T396 T392 arg1Of as,Eomes
R325 T396 T394 arg1Of as,as
R326 T396 T395 arg1Of as,well
R327 T397 T396 arg2Of expression,as
R328 T397 T398 arg1Of expression,of
R329 T401 T398 arg2Of markers,of
R330 T401 T399 arg1Of markers,three
R331 T401 T400 arg1Of markers,cardinal
R332 T401 T402 arg1Of markers,of
R333 T401 T407 arg1Of markers,:
R334 T406 T402 arg2Of program,of
R335 T406 T403 arg1Of program,the
R336 T406 T404 arg1Of program,effector
R337 T406 T405 arg1Of program,CTL
R338 T408 T409 arg1Of IFN-γ,","
R339 T409 T412 arg1Of ",",and
R340 T410 T409 arg2Of perforin,","
R341 T412 T407 arg2Of and,:
R342 T412 T411 arg1Of and,","
R343 T414 T412 arg2Of B.,and
R344 T414 T413 arg1Of B.,granzyme
R345 T416 T415 arg1Of data,Our
R346 T416 T417 arg1Of data,point
R347 T417 T391 arg3Of point,regulates
R348 T417 T418 arg1Of point,to
R349 T420 T418 arg2Of existence,to
R350 T420 T419 arg1Of existence,the
R351 T420 T421 arg1Of existence,of
R352 T420 T426 arg2Of existence,in
R353 T420 T427 arg1Of existence,which
R354 T425 T421 arg2Of network,of
R355 T425 T422 arg1Of network,an
R356 T425 T423 arg1Of network,elaborate
R357 T425 T424 arg1Of network,transcriptional
R358 T428 T430 arg1Of Runx3,induces
R359 T428 T433 arg1Of Runx3,cooperates
R360 T428 T439 arg1Of Runx3,regulate
R361 T430 T431 arg1Of induces,and
R362 T431 T426 arg1Of and,in
R363 T431 T429 arg1Of and,initially
R364 T433 T431 arg2Of cooperates,and
R365 T433 T432 arg1Of cooperates,then
R366 T433 T434 arg1Of cooperates,with
R367 T433 T438 modOf cooperates,to
R368 T437 T434 arg2Of factors,with
R369 T437 T435 arg1Of factors,T-box
R370 T437 T436 arg1Of factors,transcription
R371 T439 T438 arg1Of regulate,to
R372 T441 T439 arg2Of transcription,regulate
R373 T441 T440 arg1Of transcription,gene
R374 T441 T442 arg1Of transcription,in
R375 T444 T442 arg2Of CTLs,in
R376 T444 T443 arg1Of CTLs,differentiating

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T445 457-484 Anaphor denotes T-box transcription factors
T446 407-412 Antecedent denotes T-bet
T447 435-447 Antecedent denotes Eomesodermin
T448 734-756 Anaphor denotes three cardinal markers
T449 786-791 Antecedent denotes IFN-γ
T450 793-801 Antecedent denotes perforin
T451 807-817 Antecedent denotes granzyme B
R468 T445 T446 boundBy T-box transcription factors,T-bet
R469 T445 T447 boundBy T-box transcription factors,Eomesodermin
R470 T448 T449 boundBy three cardinal markers,IFN-γ
R471 T448 T450 boundBy three cardinal markers,perforin
R472 T448 T451 boundBy three cardinal markers,granzyme B

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T101 0-10 NNP denotes Activation
T102 11-13 IN denotes of
T103 14-19 JJ denotes naive
T104 20-23 NNP denotes CD8
T105 23-24 CD denotes +
T106 25-26 NNP denotes T
T107 27-32 NNS denotes cells
T108 33-37 IN denotes with
T109 38-45 NN denotes antigen
T110 46-53 VBZ denotes induces
T111 54-59 PRP$ denotes their
T112 60-75 NN denotes differentiation
T113 76-80 IN denotes into
T114 81-89 NN denotes effector
T115 90-99 JJ denotes cytolytic
T116 100-101 NNP denotes T
T117 102-113 NNS denotes lymphocytes
T118 114-115 -LRB- denotes (
T119 115-119 NNS denotes CTLs
T120 119-120 -RRB- denotes )
T121 120-121 . denotes .
T122 122-126 NNS denotes CTLs
T123 127-131 VBP denotes lyse
T124 132-140 JJ denotes infected
T125 141-143 CC denotes or
T126 144-152 JJ denotes aberrant
T127 153-159 NN denotes target
T128 160-165 NNS denotes cells
T129 166-168 IN denotes by
T130 169-179 NN denotes exocytosis
T131 180-182 IN denotes of
T132 183-188 JJ denotes lytic
T133 189-197 NNS denotes granules
T134 198-208 VBG denotes containing
T135 209-212 DT denotes the
T136 213-225 JJ denotes pore-forming
T137 226-233 NN denotes protein
T138 234-242 NN denotes perforin
T139 243-246 CC denotes and
T140 247-248 DT denotes a
T141 249-255 NN denotes family
T142 256-258 IN denotes of
T143 259-268 NNS denotes proteases
T144 269-275 VBD denotes termed
T145 276-285 NNS denotes granzymes
T146 285-286 . denotes .
T147 287-289 PRP denotes We
T148 290-294 VBP denotes show
T149 295-299 IN denotes that
T150 300-308 NN denotes effector
T151 309-312 NNP denotes CTL
T152 313-328 NN denotes differentiation
T153 329-335 VBZ denotes occurs
T154 336-338 IN denotes in
T155 339-342 CD denotes two
T156 343-353 JJ denotes sequential
T157 354-360 NNS denotes phases
T158 361-363 IN denotes in
T159 364-369 NN denotes vitro
T160 369-370 , denotes ,
T161 371-384 VBN denotes characterized
T162 385-387 IN denotes by
T163 388-393 JJ denotes early
T164 394-403 NN denotes induction
T165 404-406 IN denotes of
T166 407-412 NN denotes T-bet
T167 413-416 CC denotes and
T168 417-421 JJ denotes late
T169 422-431 NN denotes induction
T170 432-434 IN denotes of
T171 435-447 NNP denotes Eomesodermin
T172 448-449 -LRB- denotes (
T173 449-454 NNP denotes Eomes
T174 454-455 -RRB- denotes )
T175 455-456 , denotes ,
T176 457-462 JJ denotes T-box
T177 463-476 NN denotes transcription
T178 477-484 NNS denotes factors
T179 485-489 WDT denotes that
T180 490-498 VBP denotes regulate
T181 499-502 DT denotes the
T182 503-508 JJ denotes early
T183 509-512 CC denotes and
T184 513-517 JJ denotes late
T185 518-524 NNS denotes phases
T186 525-527 IN denotes of
T187 528-538 NN denotes interferon
T188 539-540 -LRB- denotes (
T189 540-543 NNP denotes IFN
T190 543-544 -RRB- denotes )
T191 545-546 VBP denotes γ
T192 547-557 NN denotes expression
T193 557-558 , denotes ,
T194 559-571 RB denotes respectively
T195 571-572 . denotes .
T196 573-575 IN denotes In
T197 576-584 NN denotes addition
T198 584-585 , denotes ,
T199 586-588 PRP denotes we
T200 589-600 VBP denotes demonstrate
T201 601-602 DT denotes a
T202 603-611 JJ denotes critical
T203 612-616 NN denotes role
T204 617-620 IN denotes for
T205 621-624 DT denotes the
T206 625-638 NN denotes transcription
T207 639-645 NN denotes factor
T208 646-651 NNP denotes Runx3
T209 652-654 IN denotes in
T210 655-658 NNP denotes CTL
T211 659-674 NN denotes differentiation
T212 674-675 . denotes .
T213 676-681 JJ denotes Runx3
T214 682-691 VBZ denotes regulates
T215 692-697 NNP denotes Eomes
T216 698-708 NN denotes expression
T217 709-711 RB denotes as
T218 712-716 RB denotes well
T219 717-719 IN denotes as
T220 720-730 NN denotes expression
T221 731-733 IN denotes of
T222 734-739 CD denotes three
T223 740-748 JJ denotes cardinal
T224 749-756 NNS denotes markers
T225 757-759 IN denotes of
T226 760-763 DT denotes the
T227 764-772 NN denotes effector
T228 773-776 NNP denotes CTL
T229 777-784 NN denotes program
T230 784-785 : denotes :
T231 786-791 NNP denotes IFN-γ
T232 791-792 , denotes ,
T233 793-801 NN denotes perforin
T234 801-802 , denotes ,
T235 803-806 CC denotes and
T236 807-815 NN denotes granzyme
T237 816-817 NN denotes B
T238 817-818 . denotes .
T239 819-822 PRP$ denotes Our
T240 823-827 NNS denotes data
T241 828-833 NN denotes point
T242 834-836 TO denotes to
T243 837-840 DT denotes the
T244 841-850 NN denotes existence
T245 851-853 IN denotes of
T246 854-856 DT denotes an
T247 857-866 JJ denotes elaborate
T248 867-882 JJ denotes transcriptional
T249 883-890 NN denotes network
T250 891-893 IN denotes in
T251 894-899 WDT denotes which
T252 900-905 JJ denotes Runx3
T253 906-915 RB denotes initially
T254 916-923 VBZ denotes induces
T255 924-927 CC denotes and
T256 928-932 RB denotes then
T257 933-943 VBZ denotes cooperates
T258 944-948 IN denotes with
T259 949-954 JJ denotes T-box
T260 955-968 NN denotes transcription
T261 969-976 NNS denotes factors
T262 977-979 TO denotes to
T263 980-988 VB denotes regulate
T264 989-993 NN denotes gene
T265 994-1007 NN denotes transcription
T266 1008-1010 IN denotes in
T267 1011-1026 VBG denotes differentiating
T268 1027-1031 NNS denotes CTLs
T269 1031-1032 . denotes .
R32 T101 T110 nsubj Activation,induces
R33 T102 T101 prep of,Activation
R34 T103 T107 amod naive,cells
R35 T104 T107 nmod CD8,cells
R36 T105 T107 nummod +,cells
R37 T106 T107 compound T,cells
R38 T107 T102 pobj cells,of
R39 T108 T107 prep with,cells
R40 T109 T108 pobj antigen,with
R42 T111 T112 poss their,differentiation
R43 T112 T110 dobj differentiation,induces
R44 T113 T110 prep into,induces
R45 T114 T117 nmod effector,lymphocytes
R46 T115 T117 amod cytolytic,lymphocytes
R47 T116 T117 compound T,lymphocytes
R48 T117 T113 pobj lymphocytes,into
R49 T118 T119 punct (,CTLs
R50 T119 T117 appos CTLs,lymphocytes
R51 T120 T117 punct ),lymphocytes
R52 T121 T110 punct .,induces
R53 T122 T123 nsubj CTLs,lyse
R54 T123 T123 ROOT lyse,lyse
R55 T124 T128 amod infected,cells
R56 T125 T124 cc or,infected
R57 T126 T124 conj aberrant,infected
R58 T127 T128 compound target,cells
R59 T128 T123 dobj cells,lyse
R60 T129 T123 prep by,lyse
R61 T130 T129 pobj exocytosis,by
R62 T131 T130 prep of,exocytosis
R63 T132 T133 amod lytic,granules
R64 T133 T131 pobj granules,of
R65 T134 T133 acl containing,granules
R66 T135 T138 det the,perforin
R67 T136 T138 amod pore-forming,perforin
R68 T137 T138 compound protein,perforin
R69 T138 T134 dobj perforin,containing
R70 T139 T138 cc and,perforin
R71 T140 T141 det a,family
R72 T141 T144 nsubj family,termed
R73 T142 T141 prep of,family
R74 T143 T142 pobj proteases,of
R75 T144 T123 conj termed,lyse
R76 T145 T144 dobj granzymes,termed
R77 T146 T144 punct .,termed
R78 T147 T148 nsubj We,show
R79 T148 T148 ROOT show,show
R80 T149 T153 mark that,occurs
R81 T150 T151 compound effector,CTL
R82 T151 T152 compound CTL,differentiation
R83 T152 T153 nsubj differentiation,occurs
R84 T153 T148 ccomp occurs,show
R85 T154 T153 prep in,occurs
R86 T155 T157 nummod two,phases
R87 T156 T157 amod sequential,phases
R88 T157 T154 pobj phases,in
R89 T158 T157 prep in,phases
R90 T159 T158 pobj vitro,in
R91 T160 T157 punct ",",phases
R92 T161 T157 acl characterized,phases
R93 T162 T161 agent by,characterized
R94 T163 T164 amod early,induction
R95 T164 T162 pobj induction,by
R96 T165 T164 prep of,induction
R97 T166 T165 pobj T-bet,of
R98 T167 T166 cc and,T-bet
R99 T168 T169 amod late,induction
R100 T169 T166 conj induction,T-bet
R101 T170 T169 prep of,induction
R102 T171 T170 pobj Eomesodermin,of
R103 T172 T171 punct (,Eomesodermin
R104 T173 T171 appos Eomes,Eomesodermin
R105 T174 T171 punct ),Eomesodermin
R106 T175 T178 punct ",",factors
R107 T176 T178 amod T-box,factors
R108 T177 T178 compound transcription,factors
R109 T178 T192 nmod factors,expression
R110 T179 T180 nsubj that,regulate
R111 T180 T178 relcl regulate,factors
R112 T181 T185 det the,phases
R113 T182 T185 amod early,phases
R114 T183 T182 cc and,early
R115 T184 T182 conj late,early
R116 T185 T180 dobj phases,regulate
R117 T186 T185 prep of,phases
R118 T187 T186 pobj interferon,of
R119 T188 T189 punct (,IFN
R120 T189 T178 appos IFN,factors
R121 T190 T178 punct ),factors
R122 T191 T192 compound γ,expression
R123 T192 T164 conj expression,induction
R124 T193 T164 punct ",",induction
R125 T194 T161 advmod respectively,characterized
R126 T195 T148 punct .,show
R127 T196 T200 prep In,demonstrate
R128 T197 T196 pobj addition,In
R129 T198 T200 punct ",",demonstrate
R130 T199 T200 nsubj we,demonstrate
R131 T200 T200 ROOT demonstrate,demonstrate
R132 T201 T203 det a,role
R133 T202 T203 amod critical,role
R134 T203 T200 dobj role,demonstrate
R135 T204 T203 prep for,role
R136 T205 T207 det the,factor
R137 T206 T207 compound transcription,factor
R138 T207 T204 pobj factor,for
R139 T208 T207 appos Runx3,factor
R140 T209 T208 prep in,Runx3
R141 T210 T211 compound CTL,differentiation
R142 T211 T209 pobj differentiation,in
R143 T212 T200 punct .,demonstrate
R144 T213 T214 nsubj Runx3,regulates
R145 T214 T214 ROOT regulates,regulates
R146 T215 T216 compound Eomes,expression
R147 T216 T214 dobj expression,regulates
R148 T217 T219 advmod as,as
R149 T218 T219 advmod well,as
R150 T219 T216 cc as,expression
R151 T220 T216 conj expression,expression
R152 T221 T216 prep of,expression
R153 T222 T224 nummod three,markers
R154 T223 T224 compound cardinal,markers
R155 T224 T221 pobj markers,of
R156 T225 T224 prep of,markers
R157 T226 T229 det the,program
R158 T227 T228 compound effector,CTL
R159 T228 T229 compound CTL,program
R160 T229 T225 pobj program,of
R161 T230 T224 punct :,markers
R162 T231 T224 appos IFN-γ,markers
R163 T232 T231 punct ",",IFN-γ
R164 T233 T231 conj perforin,IFN-γ
R165 T234 T233 punct ",",perforin
R166 T235 T233 cc and,perforin
R167 T236 T237 compound granzyme,B
R168 T237 T233 conj B,perforin
R169 T238 T214 punct .,regulates
R170 T239 T241 poss Our,point
R171 T240 T241 compound data,point
R172 T241 T241 ROOT point,point
R173 T242 T241 prep to,point
R174 T243 T244 det the,existence
R175 T244 T242 pobj existence,to
R176 T245 T244 prep of,existence
R177 T246 T249 det an,network
R178 T247 T249 amod elaborate,network
R179 T248 T249 compound transcriptional,network
R180 T249 T245 pobj network,of
R181 T250 T254 prep in,induces
R182 T251 T250 pobj which,in
R183 T252 T254 nsubj Runx3,induces
R184 T253 T254 advmod initially,induces
R185 T254 T249 relcl induces,network
R186 T255 T254 cc and,induces
R187 T256 T257 advmod then,cooperates
R188 T257 T254 conj cooperates,induces
R189 T258 T257 prep with,cooperates
R190 T259 T261 amod T-box,factors
R191 T260 T261 compound transcription,factors
R192 T261 T258 pobj factors,with
R193 T262 T263 aux to,regulate
R194 T263 T257 advcl regulate,cooperates
R195 T264 T265 compound gene,transcription
R196 T265 T263 dobj transcription,regulate
R197 T266 T263 prep in,regulate
R198 T267 T266 pcomp differentiating,in
R199 T268 T267 dobj CTLs,differentiating
R200 T269 T241 punct .,point

UBERON-AE

Id Subject Object Predicate Lexical cue
T28 213-217 http://purl.obolibrary.org/obo/UBERON_0008915 denotes pore

GO-BP

Id Subject Object Predicate Lexical cue
T84 867-882 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T85 955-968 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T86 994-1007 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T87 169-179 http://purl.obolibrary.org/obo/GO_0006887 denotes exocytosis

GO-CC

Id Subject Object Predicate Lexical cue
T471 27-32 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T472 160-165 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T473 213-217 http://purl.obolibrary.org/obo/GO_0046930 denotes pore

sentences

Id Subject Object Predicate Lexical cue
T78 0-121 Sentence denotes Activation of naive CD8+ T cells with antigen induces their differentiation into effector cytolytic T lymphocytes (CTLs).
T79 122-286 Sentence denotes CTLs lyse infected or aberrant target cells by exocytosis of lytic granules containing the pore-forming protein perforin and a family of proteases termed granzymes.
T80 287-572 Sentence denotes We show that effector CTL differentiation occurs in two sequential phases in vitro, characterized by early induction of T-bet and late induction of Eomesodermin (Eomes), T-box transcription factors that regulate the early and late phases of interferon (IFN) γ expression, respectively.
T81 573-675 Sentence denotes In addition, we demonstrate a critical role for the transcription factor Runx3 in CTL differentiation.
T82 676-1032 Sentence denotes Runx3 regulates Eomes expression as well as expression of three cardinal markers of the effector CTL program: IFN-γ, perforin, and granzyme B. Our data point to the existence of an elaborate transcriptional network in which Runx3 initially induces and then cooperates with T-box transcription factors to regulate gene transcription in differentiating CTLs.
T3 0-121 Sentence denotes Activation of naive CD8+ T cells with antigen induces their differentiation into effector cytolytic T lymphocytes (CTLs).
T4 122-286 Sentence denotes CTLs lyse infected or aberrant target cells by exocytosis of lytic granules containing the pore-forming protein perforin and a family of proteases termed granzymes.
T5 287-572 Sentence denotes We show that effector CTL differentiation occurs in two sequential phases in vitro, characterized by early induction of T-bet and late induction of Eomesodermin (Eomes), T-box transcription factors that regulate the early and late phases of interferon (IFN) γ expression, respectively.
T6 573-675 Sentence denotes In addition, we demonstrate a critical role for the transcription factor Runx3 in CTL differentiation.
T7 676-818 Sentence denotes Runx3 regulates Eomes expression as well as expression of three cardinal markers of the effector CTL program: IFN-γ, perforin, and granzyme B.
T8 819-1032 Sentence denotes Our data point to the existence of an elaborate transcriptional network in which Runx3 initially induces and then cooperates with T-box transcription factors to regulate gene transcription in differentiating CTLs.

events-check-again

Id Subject Object Predicate Lexical cue
T618 720-730 Gene_expression denotes expression
T619 720-730 Gene_expression denotes expression
T620 786-791 Protein denotes IFN-γ
T621 793-801 Protein denotes perforin
T622 807-817 Protein denotes granzyme B
T623 900-905 Protein denotes Runx3
T598 20-23 Protein denotes CD8
T599 234-242 Protein denotes perforin
T600 394-403 Positive_regulation denotes induction
T601 407-412 Protein denotes T-bet
T602 422-431 Positive_regulation denotes induction
T603 435-447 Protein denotes Eomesodermin
T604 449-454 Protein denotes Eomes
T605 490-498 Regulation denotes regulate
T606 490-498 Regulation denotes regulate
T607 528-546 Protein denotes interferon (IFN) γ
T608 547-557 Gene_expression denotes expression
T609 646-651 Protein denotes Runx3
T610 676-681 Protein denotes Runx3
T611 682-691 Regulation denotes regulates
T612 682-691 Regulation denotes regulates
T613 682-691 Regulation denotes regulates
T614 682-691 Regulation denotes regulates
T615 692-697 Protein denotes Eomes
T616 698-708 Gene_expression denotes expression
T617 720-730 Gene_expression denotes expression
R508 T601 T600 themeOf T-bet,induction
R510 T603 T602 themeOf Eomesodermin,induction
R511 T604 T603 equivalentTo Eomes,Eomesodermin
R512 T607 T608 themeOf interferon (IFN) γ,expression
R513 T608 T606 themeOf expression,regulate
R514 T608 T605 themeOf expression,regulate
R515 T610 T611 causeOf Runx3,regulates
R516 T610 T614 causeOf Runx3,regulates
R517 T610 T612 causeOf Runx3,regulates
R518 T610 T613 causeOf Runx3,regulates
R519 T615 T616 themeOf Eomes,expression
R520 T616 T611 themeOf expression,regulates
R521 T617 T614 themeOf expression,regulates
R522 T618 T612 themeOf expression,regulates
R523 T619 T613 themeOf expression,regulates
R524 T620 T617 themeOf IFN-γ,expression
R525 T621 T618 themeOf perforin,expression
R526 T622 T619 themeOf granzyme B,expression
R507 T601 T606 causeOf T-bet,regulate
R509 T603 T605 causeOf Eomesodermin,regulate

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T625 20-24 Protein denotes CD8+
T626 234-242 Protein denotes perforin
T627 457-484 Protein denotes T-box transcription factors
T628 528-538 Protein denotes interferon
T629 540-543 Protein denotes IFN
T630 625-651 Protein denotes transcription factor Runx3
T631 676-681 Protein denotes Runx3
T632 786-791 Protein denotes IFN-γ
T633 793-801 Protein denotes perforin
T634 807-817 Protein denotes granzyme B
T635 720-730 Gene_expression denotes expression
T636 720-730 Gene_expression denotes expression
T637 720-730 Gene_expression denotes expression
T638 682-691 Regulation denotes regulates
T639 682-691 Regulation denotes regulates
T640 682-691 Regulation denotes regulates
T641 900-905 Protein denotes Runx3
T642 949-976 Protein denotes T-box transcription factors
R429 T631 T638 causeOf Runx3,regulates
R430 T631 T639 causeOf Runx3,regulates
R431 T631 T640 causeOf Runx3,regulates
R432 T632 T635 themeOf IFN-γ,expression
R527 T633 T636 themeOf perforin,expression
R528 T634 T637 themeOf granzyme B,expression
R529 T635 T638 themeOf expression,regulates
R530 T636 T639 themeOf expression,regulates
R531 T637 T640 themeOf expression,regulates

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue
T51 20-23 Protein denotes CD8
T62 646-651 Protein denotes Runx3
T63 676-681 Protein denotes Runx3
T64 682-691 Regulation denotes regulates
T65 682-691 Regulation denotes regulates
T66 682-691 Regulation denotes regulates
T67 682-691 Regulation denotes regulates
T68 692-697 Protein denotes Eomes
T69 698-708 Gene_expression denotes expression
T70 720-730 Gene_expression denotes expression
T71 720-730 Gene_expression denotes expression
T72 720-730 Gene_expression denotes expression
T73 786-791 Protein denotes IFN-γ
T74 793-801 Protein denotes perforin
T75 807-817 Protein denotes granzyme B
T76 900-905 Protein denotes Runx3
T52 234-242 Protein denotes perforin
T53 394-403 Positive_regulation denotes induction
T54 407-412 Protein denotes T-bet
T55 422-431 Positive_regulation denotes induction
T56 435-447 Protein denotes Eomesodermin
T57 449-454 Protein denotes Eomes
T58 490-498 Regulation denotes regulate
T59 490-498 Regulation denotes regulate
T60 528-546 Protein denotes interferon (IFN) γ
T61 547-557 Gene_expression denotes expression
R448 T54 T59 causeOf T-bet,regulate
R449 T54 T53 themeOf T-bet,induction
R450 T56 T58 causeOf Eomesodermin,regulate
R451 T56 T55 themeOf Eomesodermin,induction
R452 T57 T56 equivalentTo Eomes,Eomesodermin
R453 T60 T61 themeOf interferon (IFN) γ,expression
R454 T61 T59 themeOf expression,regulate
R455 T61 T58 themeOf expression,regulate
R456 T63 T64 causeOf Runx3,regulates
R457 T63 T67 causeOf Runx3,regulates
R458 T63 T65 causeOf Runx3,regulates
R459 T63 T66 causeOf Runx3,regulates
R460 T68 T69 themeOf Eomes,expression
R461 T69 T64 themeOf expression,regulates
R462 T70 T67 themeOf expression,regulates
R463 T71 T65 themeOf expression,regulates
R464 T72 T66 themeOf expression,regulates
R465 T73 T70 themeOf IFN-γ,expression
R466 T74 T71 themeOf perforin,expression
R467 T75 T72 themeOf granzyme B,expression

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T453 20-23 P01732 denotes CD8
T454 20-23 P10966 denotes CD8
T455 234-242 P14222 denotes perforin
T456 407-412 Q9UL17 denotes T-bet
T457 449-454 O95936 denotes Eomes
T458 646-651 Q13761 denotes Runx3
T459 676-681 Q13761 denotes Runx3
T460 692-697 O95936 denotes Eomes
T461 786-791 P01579 denotes IFN-γ
T462 793-801 P14222 denotes perforin
T463 807-817 P10144 denotes granzyme B
T464 900-905 Q13761 denotes Runx3

test2

Id Subject Object Predicate Lexical cue
T30 20-23 Protein denotes CD8
T31 234-242 Protein denotes perforin
T32 394-403 Positive_regulation denotes induction
T33 407-412 Protein denotes T-bet
T34 422-431 Positive_regulation denotes induction
T35 435-447 Protein denotes Eomesodermin
T36 449-454 Protein denotes Eomes
T37 490-498 Regulation denotes regulate
T38 528-546 Protein denotes interferon (IFN) γ
T39 547-557 Gene_expression denotes expression
T40 646-651 Protein denotes Runx3
T41 676-681 Protein denotes Runx3
T42 682-691 Regulation denotes regulates
T43 692-697 Protein denotes Eomes
T44 698-708 Gene_expression denotes expression
T45 720-730 Gene_expression denotes expression
T46 786-791 Protein denotes IFN-γ
T47 793-801 Protein denotes perforin
T48 807-817 Protein denotes granzyme B
T49 900-905 Protein denotes Runx3
R435 T33 T37 causeOf T-bet,regulate
R436 T33 T32 themeOf T-bet,induction
R437 T35 T34 themeOf Eomesodermin,induction
R438 T35 T37 causeOf Eomesodermin,regulate
R439 T36 T35 equivalentTo Eomes,Eomesodermin
R440 T38 T39 themeOf interferon (IFN) γ,expression
R441 T39 T37 themeOf expression,regulate
R442 T41 T42 causeOf Runx3,regulates
R443 T43 T44 themeOf Eomes,expression
R444 T44 T42 themeOf expression,regulates
R445 T46 T45 themeOf IFN-γ,expression
R446 T47 T45 themeOf perforin,expression
R447 T48 T45 themeOf granzyme B,expression