PMC:2575619 / 139-947 JSONTXT

{"project":"Biotea","denotations":[{"id":"T2","span":{"begin":725,"end":730},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25586"},{"id":"T25","span":{"begin":301,"end":309},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18106"},{"id":"T26","span":{"begin":680,"end":688},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18106"},{"id":"T40","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T41","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T55","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T56","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T70","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T71","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T85","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T86","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T100","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T101","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T115","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T116","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T130","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T131","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T145","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T146","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T160","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T161","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/STY/T192"},{"id":"T175","span":{"begin":301,"end":309},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/116647005"},{"id":"T176","span":{"begin":680,"end":688},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/116647005"},{"id":"T207","span":{"begin":199,"end":209},"obj":"http://purl.bioontology.org/ontology/MESH/D013812"},{"id":"T209","span":{"begin":77,"end":97},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0003873"},{"id":"T210","span":{"begin":393,"end":413},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0003873"},{"id":"T213","span":{"begin":77,"end":97},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU049127"},{"id":"T214","span":{"begin":393,"end":413},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU049127"},{"id":"T217","span":{"begin":77,"end":97},"obj":"http://purl.bioontology.org/ontology/OMIM/180300"},{"id":"T218","span":{"begin":393,"end":413},"obj":"http://purl.bioontology.org/ontology/OMIM/180300"},{"id":"T221","span":{"begin":77,"end":97},"obj":"http://purl.bioontology.org/ontology/MESH/D001172"},{"id":"T222","span":{"begin":393,"end":413},"obj":"http://purl.bioontology.org/ontology/MESH/D001172"},{"id":"T225","span":{"begin":77,"end":97},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2884"},{"id":"T226","span":{"begin":393,"end":413},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2884"},{"id":"T229","span":{"begin":77,"end":97},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10039073"},{"id":"T230","span":{"begin":393,"end":413},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10039073"},{"id":"T233","span":{"begin":77,"end":97},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/69896004"},{"id":"T234","span":{"begin":393,"end":413},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/69896004"},{"id":"T237","span":{"begin":88,"end":97},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU001688"},{"id":"T238","span":{"begin":404,"end":413},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU001688"},{"id":"T239","span":{"begin":798,"end":807},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU001688"},{"id":"T245","span":{"begin":88,"end":97},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0003864"},{"id":"T246","span":{"begin":404,"end":413},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0003864"},{"id":"T247","span":{"begin":798,"end":807},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0003864"},{"id":"T253","span":{"begin":88,"end":97},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10003246"},{"id":"T254","span":{"begin":404,"end":413},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10003246"},{"id":"T255","span":{"begin":798,"end":807},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10003246"},{"id":"T261","span":{"begin":88,"end":97},"obj":"http://purl.obolibrary.org/obo/SYMP_0019169"},{"id":"T262","span":{"begin":404,"end":413},"obj":"http://purl.obolibrary.org/obo/SYMP_0019169"},{"id":"T263","span":{"begin":798,"end":807},"obj":"http://purl.obolibrary.org/obo/SYMP_0019169"},{"id":"T269","span":{"begin":88,"end":97},"obj":"http://purl.bioontology.org/ontology/MESH/D001168"},{"id":"T270","span":{"begin":404,"end":413},"obj":"http://purl.bioontology.org/ontology/MESH/D001168"},{"id":"T271","span":{"begin":798,"end":807},"obj":"http://purl.bioontology.org/ontology/MESH/D001168"},{"id":"T277","span":{"begin":88,"end":97},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2883"},{"id":"T278","span":{"begin":404,"end":413},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2883"},{"id":"T279","span":{"begin":798,"end":807},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2883"},{"id":"T285","span":{"begin":88,"end":97},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/3723001"},{"id":"T286","span":{"begin":404,"end":413},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/3723001"},{"id":"T287","span":{"begin":798,"end":807},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/3723001"},{"id":"T294","span":{"begin":88,"end":97},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000000478"},{"id":"T295","span":{"begin":404,"end":413},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000000478"},{"id":"T296","span":{"begin":798,"end":807},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000000478"},{"id":"T302","span":{"begin":88,"end":97},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C143299"},{"id":"T303","span":{"begin":404,"end":413},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C143299"},{"id":"T304","span":{"begin":798,"end":807},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C143299"},{"id":"T309","span":{"begin":0,"end":12},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/107733003"},{"id":"T310","span":{"begin":0,"end":12},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000029363"},{"id":"T311","span":{"begin":35,"end":45},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28226"},{"id":"T313","span":{"begin":35,"end":45},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C96100"},{"id":"T314","span":{"begin":35,"end":45},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/12893009"},{"id":"T316","span":{"begin":35,"end":45},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16345"},{"id":"T318","span":{"begin":64,"end":73},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C70742"},{"id":"T319","span":{"begin":64,"end":73},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49656"},{"id":"T320","span":{"begin":64,"end":73},"obj":"http://purl.bioontology.org/ontology/MESH/Q000628"},{"id":"T321","span":{"begin":64,"end":73},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43442"},{"id":"T322","span":{"begin":64,"end":73},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15368"},{"id":"T323","span":{"begin":64,"end":73},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25409"},{"id":"T324","span":{"begin":64,"end":73},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49236"},{"id":"T325","span":{"begin":64,"end":73},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C101526"},{"id":"T326","span":{"begin":64,"end":73},"obj":"http://purl.obolibrary.org/obo/OGMS_0000090"},{"id":"T327","span":{"begin":105,"end":109},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/116680003"},{"id":"T328","span":{"begin":137,"end":148},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25415"},{"id":"T329","span":{"begin":488,"end":499},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25415"},{"id":"T330","span":{"begin":628,"end":639},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25415"},{"id":"T332","span":{"begin":149,"end":160},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25277"},{"id":"T333","span":{"begin":754,"end":765},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25277"},{"id":"T335","span":{"begin":149,"end":160},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/262202000"},{"id":"T336","span":{"begin":754,"end":765},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/262202000"},{"id":"T338","span":{"begin":211,"end":218},"obj":"http://purl.obolibrary.org/obo/GO_0005625"},{"id":"T339","span":{"begin":211,"end":218},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64364"},{"id":"T340","span":{"begin":229,"end":234},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54069"},{"id":"T341","span":{"begin":229,"end":234},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25275"},{"id":"T342","span":{"begin":229,"end":234},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C127786"},{"id":"T343","span":{"begin":245,"end":252},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15744"},{"id":"T344","span":{"begin":781,"end":788},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15744"},{"id":"T347","span":{"begin":273,"end":280},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/40885006"},{"id":"T348","span":{"begin":273,"end":280},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25713"},{"id":"T349","span":{"begin":288,"end":309},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17067"},{"id":"T350","span":{"begin":667,"end":688},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17067"},{"id":"T351","span":{"begin":288,"end":300},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T352","span":{"begin":667,"end":679},"obj":"http://purl.obolibrary.org/obo/GO_0009986"},{"id":"T354","span":{"begin":288,"end":300},"obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"T355","span":{"begin":667,"end":679},"obj":"http://purl.org/sig/ont/fma/fma67653"},{"id":"T357","span":{"begin":288,"end":300},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33974"},{"id":"T358","span":{"begin":667,"end":679},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C33974"},{"id":"T360","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T361","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T363","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T364","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T366","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T367","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T369","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T370","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T372","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T373","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T375","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T376","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T378","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T379","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T381","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T382","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T384","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T385","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/STY/T025"},{"id":"T387","span":{"begin":288,"end":292},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49867"},{"id":"T388","span":{"begin":667,"end":671},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49867"},{"id":"T390","span":{"begin":288,"end":292},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T391","span":{"begin":667,"end":671},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T393","span":{"begin":288,"end":292},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12508"},{"id":"T394","span":{"begin":667,"end":671},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12508"},{"id":"T397","span":{"begin":288,"end":292},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23442"},{"id":"T398","span":{"begin":667,"end":671},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C23442"},{"id":"T400","span":{"begin":288,"end":292},"obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"T401","span":{"begin":667,"end":671},"obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"T403","span":{"begin":288,"end":292},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T404","span":{"begin":667,"end":671},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T406","span":{"begin":288,"end":292},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T407","span":{"begin":667,"end":671},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T409","span":{"begin":288,"end":292},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60787"},{"id":"T410","span":{"begin":667,"end":671},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C60787"},{"id":"T412","span":{"begin":288,"end":292},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48694"},{"id":"T413","span":{"begin":667,"end":671},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48694"},{"id":"T415","span":{"begin":288,"end":292},"obj":"http://purl.bioontology.org/ontology/MESH/D002477"},{"id":"T416","span":{"begin":667,"end":671},"obj":"http://purl.bioontology.org/ontology/MESH/D002477"},{"id":"T418","span":{"begin":293,"end":300},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25245"},{"id":"T419","span":{"begin":672,"end":679},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25245"},{"id":"T421","span":{"begin":293,"end":300},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/410678000"},{"id":"T422","span":{"begin":672,"end":679},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/410678000"},{"id":"T424","span":{"begin":293,"end":300},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/410679008"},{"id":"T425","span":{"begin":672,"end":679},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/410679008"},{"id":"T427","span":{"begin":314,"end":348},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129646"},{"id":"T428","span":{"begin":350,"end":354},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C129646"},{"id":"T435","span":{"begin":314,"end":348},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20450"},{"id":"T436","span":{"begin":350,"end":354},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20450"},{"id":"T443","span":{"begin":314,"end":348},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C92514"},{"id":"T444","span":{"begin":350,"end":354},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C92514"},{"id":"T451","span":{"begin":314,"end":348},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1272"},{"id":"T452","span":{"begin":350,"end":354},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1272"},{"id":"T459","span":{"begin":314,"end":348},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/417324009"},{"id":"T460","span":{"begin":314,"end":348},"obj":"http://purl.obolibrary.org/obo/GO_0005172"},{"id":"T461","span":{"begin":314,"end":322},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C13311"},{"id":"T462","span":{"begin":314,"end":322},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU000113"},{"id":"T463","span":{"begin":314,"end":322},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C53809"},{"id":"T464","span":{"begin":323,"end":334},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12481"},{"id":"T465","span":{"begin":335,"end":348},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/81286007"},{"id":"T470","span":{"begin":335,"end":348},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20424"},{"id":"T475","span":{"begin":335,"end":341},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C64379"},{"id":"T480","span":{"begin":335,"end":341},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T485","span":{"begin":335,"end":341},"obj":"http://purl.bioontology.org/ontology/OMIM/MTHU000046"},{"id":"T490","span":{"begin":335,"end":341},"obj":"http://purl.bioontology.org/ontology/MESH/D006128"},{"id":"T495","span":{"begin":335,"end":341},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C18825"},{"id":"T500","span":{"begin":335,"end":341},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16648"},{"id":"T505","span":{"begin":342,"end":348},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C25506"},{"id":"T511","span":{"begin":342,"end":348},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C84380"},{"id":"T517","span":{"begin":350,"end":354},"obj":"http://purl.obolibrary.org/obo/PR_P16612"},{"id":"T524","span":{"begin":350,"end":354},"obj":"http://purl.bioontology.org/ontology/OMIM/192240"},{"id":"T531","span":{"begin":350,"end":354},"obj":"http://purl.obolibrary.org/obo/PR_000017284"},{"id":"T538","span":{"begin":350,"end":354},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C52018"},{"id":"T545","span":{"begin":350,"end":354},"obj":"http://purl.obolibrary.org/obo/PR_P67964"},{"id":"T552","span":{"begin":350,"end":354},"obj":"http://purl.bioontology.org/ontology/MESH/D042461"},{"id":"T559","span":{"begin":350,"end":354},"obj":"http://purl.obolibrary.org/obo/PR_O73682"},{"id":"T566","span":{"begin":360,"end":363},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46002"},{"id":"T568","span":{"begin":364,"end":373},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48806"},{"id":"T569","span":{"begin":555,"end":565},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48806"},{"id":"T570","span":{"begin":364,"end":373},"obj":"http://purl.obolibrary.org/obo/OBI_0000014"},{"id":"T571","span":{"begin":364,"end":373},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C50137"},{"id":"T572","span":{"begin":377,"end":389},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17932"},{"id":"T576","span":{"begin":377,"end":389},"obj":"http://purl.obolibrary.org/obo/GO_0001525"},{"id":"T580","span":{"begin":377,"end":389},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19361"},{"id":"T584","span":{"begin":415,"end":429},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17964"},{"id":"T585","span":{"begin":468,"end":473},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C14225"},{"id":"T588","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T591","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T594","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T597","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T600","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T603","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T606","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T609","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T612","span":{"begin":468,"end":473},"obj":"http://purl.bioontology.org/ontology/STY/T016"},{"id":"T615","span":{"begin":468,"end":473},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T618","span":{"begin":468,"end":473},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T621","span":{"begin":474,"end":479},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612"},{"id":"T622","span":{"begin":689,"end":694},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612"},{"id":"T624","span":{"begin":474,"end":479},"obj":"http://purl.bioontology.org/ontology/MESH/D005796"},{"id":"T625","span":{"begin":689,"end":694},"obj":"http://purl.bioontology.org/ontology/MESH/D005796"},{"id":"T627","span":{"begin":488,"end":508},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16280"},{"id":"T628","span":{"begin":488,"end":508},"obj":"http://purl.bioontology.org/ontology/MESH/D017398"},{"id":"T629","span":{"begin":500,"end":508},"obj":"http://purl.obolibrary.org/obo/GO_0045292"},{"id":"T630","span":{"begin":500,"end":508},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17106"},{"id":"T631","span":{"begin":521,"end":529},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000005817"},{"id":"T632","span":{"begin":731,"end":739},"obj":"http://purl.bioontology.org/ontology/NDFRT/N0000005817"},{"id":"T634","span":{"begin":521,"end":529},"obj":"http://purl.bioontology.org/ontology/MESH/D011506"},{"id":"T635","span":{"begin":731,"end":739},"obj":"http://purl.bioontology.org/ontology/MESH/D011506"},{"id":"T637","span":{"begin":521,"end":529},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0033684"},{"id":"T638","span":{"begin":731,"end":739},"obj":"http://purl.bioontology.org/ontology/MEDLINEPLUS/C0033684"},{"id":"T640","span":{"begin":521,"end":529},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T641","span":{"begin":731,"end":739},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17021"},{"id":"T643","span":{"begin":566,"end":575},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142468"},{"id":"T644","span":{"begin":581,"end":590},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C49155"},{"id":"T645","span":{"begin":581,"end":590},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142450"},{"id":"T646","span":{"begin":581,"end":590},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C88181"},{"id":"T647","span":{"begin":581,"end":590},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/260224007"},{"id":"T648","span":{"begin":606,"end":611},"obj":"http://purl.obolibrary.org/obo/OBI_0000073"},{"id":"T651","span":{"begin":606,"end":611},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/224699009"},{"id":"T654","span":{"begin":606,"end":611},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45319"},{"id":"T657","span":{"begin":606,"end":611},"obj":"http://purl.obolibrary.org/obo/OBI_0000066"},{"id":"T660","span":{"begin":606,"end":611},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63537"},{"id":"T663","span":{"begin":606,"end":611},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C15206"},{"id":"T666","span":{"begin":606,"end":611},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63536"},{"id":"T669","span":{"begin":657,"end":660},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C135018"},{"id":"T679","span":{"begin":657,"end":660},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C51124"},{"id":"T689","span":{"begin":657,"end":660},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C114982"},{"id":"T699","span":{"begin":703,"end":712},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C136827"},{"id":"T700","span":{"begin":740,"end":747},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80216"},{"id":"T702","span":{"begin":766,"end":774},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43431"},{"id":"T704","span":{"begin":766,"end":774},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C120914"},{"id":"T706","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T708","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T710","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T712","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T714","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T716","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T718","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T720","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T722","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/STY/T052"},{"id":"T724","span":{"begin":766,"end":774},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C123268"},{"id":"T726","span":{"begin":766,"end":774},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45329"},{"id":"T728","span":{"begin":766,"end":774},"obj":"http://purl.bioontology.org/ontology/SNOMEDCT/257733005"},{"id":"T730","span":{"begin":781,"end":794},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C19148"},{"id":"T731","span":{"begin":789,"end":794},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C43383"},{"id":"T733","span":{"begin":789,"end":794},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16866"},{"id":"T735","span":{"begin":789,"end":794},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C80519"},{"id":"T737","span":{"begin":789,"end":794},"obj":"http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C99285"}],"namespaces":[{"prefix":"omim","uri":"http://purl.bioontology.org/ontology/OMIM/"},{"prefix":"pr","uri":"http://purl.obolibrary.org/obo/PR_"}],"text":"Introduction\nDespite the advent of biological therapies for the treatment of rheumatoid arthritis, there is a compelling need to develop alternative therapeutic targets for nonresponders to existing treatments. Soluble receptors occur naturally in vivo, such as the splice variant of the cell surface receptor for vascular endothelial growth factor (VEGF) – a key regulator of angiogenesis in rheumatoid arthritis. Bioinformatics analyses predict that the majority of human genes undergo alternative splicing, generating proteins – many of which may have regulatory functions. The objective of the present study was to identify alternative splice variants (ASV) from cell surface receptor genes, and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis."}