PMC:2518050 / 1255-2670 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2518050","sourcedb":"PMC","sourceid":"2518050","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2518050","text":"Immediate-early gene (IEG) activation is dynamically regulated by neural activity and suggested to be involved in synaptic plasticity and memory consolidation (Guzowski, 2002). IEGs can function as transcription factors (i.e., c-fos, zif268), or encode “effector” proteins (i.e., Arc, Homer1a, Ania 3), which can directly impact postsynaptic signaling mechanisms in excitatory neurons (Lanahan and Worley, 1998). Homer1a, a prominent IEG, is generated by synaptic activity-induced conversion of intronic to exonic sequence during transcription of the Homer1 gene (Bottai et al., 2002), which, unique among three Homer genes, has evolved binary expression of constitutive long (Homer1b/c) and short IEG products (Homer1a, Ania 3) (Brakeman et al., 1997). Long Homer isoforms feature an N-terminal EVH1 domain, which binds proline-rich motives in key signaling constituents of the postsynaptic spine (Naisbitt et al., 1999; Tu et al., 1998) and a C-terminal coiled-coil domain and leucine zipper for multimerization. These two domains permit long Homer proteins to physically link postsynaptic signaling complexes. The IEG form Homer1a lacks the C-terminal coiled-coil domain and hence competes with long Homer isoforms in binding postsynaptic signaling proteins (Xiao et al., 2000). Therefore, Homer1a functions as an endogenous dominant negative regulator of synaptic signaling, and possibly of synaptic plasticity.","tracks":[{"project":"0_colil","denotations":[{"id":"18982121-11918292-359840","span":{"begin":170,"end":174},"obj":"11918292"},{"id":"18982121-9753585-359841","span":{"begin":406,"end":410},"obj":"9753585"},{"id":"18982121-11756499-359842","span":{"begin":579,"end":583},"obj":"11756499"},{"id":"18982121-9069287-359843","span":{"begin":747,"end":751},"obj":"9069287"},{"id":"18982121-10433268-359844","span":{"begin":916,"end":920},"obj":"10433268"},{"id":"18982121-9808459-359845","span":{"begin":933,"end":937},"obj":"9808459"},{"id":"18982121-10851183-359846","span":{"begin":1275,"end":1279},"obj":"10851183"}],"attributes":[{"subj":"18982121-11918292-359840","pred":"source","obj":"0_colil"},{"subj":"18982121-9753585-359841","pred":"source","obj":"0_colil"},{"subj":"18982121-11756499-359842","pred":"source","obj":"0_colil"},{"subj":"18982121-9069287-359843","pred":"source","obj":"0_colil"},{"subj":"18982121-10433268-359844","pred":"source","obj":"0_colil"},{"subj":"18982121-9808459-359845","pred":"source","obj":"0_colil"},{"subj":"18982121-10851183-359846","pred":"source","obj":"0_colil"}]},{"project":"2_test","denotations":[{"id":"18982121-11918292-38286585","span":{"begin":170,"end":174},"obj":"11918292"},{"id":"18982121-9753585-38286586","span":{"begin":406,"end":410},"obj":"9753585"},{"id":"18982121-11756499-38286587","span":{"begin":579,"end":583},"obj":"11756499"},{"id":"18982121-9069287-38286588","span":{"begin":747,"end":751},"obj":"9069287"},{"id":"18982121-10433268-38286589","span":{"begin":916,"end":920},"obj":"10433268"},{"id":"18982121-9808459-38286590","span":{"begin":933,"end":937},"obj":"9808459"},{"id":"18982121-10851183-38286591","span":{"begin":1275,"end":1279},"obj":"10851183"}],"attributes":[{"subj":"18982121-11918292-38286585","pred":"source","obj":"2_test"},{"subj":"18982121-9753585-38286586","pred":"source","obj":"2_test"},{"subj":"18982121-11756499-38286587","pred":"source","obj":"2_test"},{"subj":"18982121-9069287-38286588","pred":"source","obj":"2_test"},{"subj":"18982121-10433268-38286589","pred":"source","obj":"2_test"},{"subj":"18982121-9808459-38286590","pred":"source","obj":"2_test"},{"subj":"18982121-10851183-38286591","pred":"source","obj":"2_test"}]},{"project":"TEST0","denotations":[{"id":"18982121-170-178-359840","span":{"begin":170,"end":174},"obj":"[\"11918292\"]"},{"id":"18982121-229-237-359841","span":{"begin":406,"end":410},"obj":"[\"9753585\"]"},{"id":"18982121-166-174-359842","span":{"begin":579,"end":583},"obj":"[\"11756499\"]"},{"id":"18982121-233-241-359843","span":{"begin":747,"end":751},"obj":"[\"9069287\"]"},{"id":"18982121-162-170-359844","span":{"begin":916,"end":920},"obj":"[\"10433268\"]"},{"id":"18982121-179-187-359845","span":{"begin":933,"end":937},"obj":"[\"9808459\"]"},{"id":"18982121-162-170-359846","span":{"begin":1275,"end":1279},"obj":"[\"10851183\"]"}],"attributes":[{"subj":"18982121-170-178-359840","pred":"source","obj":"TEST0"},{"subj":"18982121-229-237-359841","pred":"source","obj":"TEST0"},{"subj":"18982121-166-174-359842","pred":"source","obj":"TEST0"},{"subj":"18982121-233-241-359843","pred":"source","obj":"TEST0"},{"subj":"18982121-162-170-359844","pred":"source","obj":"TEST0"},{"subj":"18982121-179-187-359845","pred":"source","obj":"TEST0"},{"subj":"18982121-162-170-359846","pred":"source","obj":"TEST0"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"0_colil","color":"#ec93e3","default":true},{"id":"2_test","color":"#93ecdb"},{"id":"TEST0","color":"#ecc093"}]}]}}