PMC:2495071 / 20343-21290 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2495071","sourcedb":"PMC","sourceid":"2495071","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2495071","text":"A significant elevation of IFN-β reactivity is seen for DRB1∗0401 and DRB1∗0408 (in bold) after adjustment for multiple testing. Only alleles that occurred more than twice are shown. In contrast to the findings in the low-resolution analysis, a significant increase of anti-IFN-β levels in DRB1∗1601-positive subjects vanishes after the FDR procedure. Likewise, the potential protective effect of DRB1∗0404 does not pass the significance criterion after adjustment for multiple testing. In the validation group, a significant elevation of IFN-β reactivity is seen in single tests for DRB∗0401 (in bold) as well as for DRB1∗0408. Because of an insufficient number of cases, however, significance vanishes after correction for multiple tests for DRB1∗0408. Because of the small number of cases, a potential protective effect of DRB1∗0402 did not pass the FDR significance criterion. The results in the validation group support our previous findings.","tracks":[]}