PMC:2493521 / 38836-40204 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2493521","sourcedb":"PMC","sourceid":"2493521","source_url":"http://www.ncbi.nlm.nih.gov/pmc/2493521","text":"Diagnosis of neurodegenerative disorders\nDiagnostic criteria have been amply discussed in the literature and will not be reviewed here. For a summary of the current general approach, the reader is referred to a recently-published algorithm (Dickson 2005). Published clinicopathologic consensus criteria are used for most conditions, incorporating clinical determinations of cognitive status and the presence or absence of other neurologic signs as well as pertinent medical history. The diagnoses of cases coming to autopsy in the Brain Donation Program since 1997 are given in Table 3. The frequency of different conditions reflects recruiting priorities, which have been focused on normal elderly controls, Alzheimer’s disease and Parkinson’s disease. Noteworthy, however, are the relatively high frequencies of non-Alzheimer’s dementias, particularly dementia with Lewy bodies, progressive supranuclear palsy and hippocampal sclerosis, all of which have often come to autopsy as clinically-diagnosed Alzheimer’s disease. Also notable is the frequent co-existence of more than one major neuropathological condition in the same subject.\nTable 3 Neuropathological diagnoses, 1997–2007 As more than one condition was often present in a single subject, the sum of the percentages exceeds 100\naNo major clinical neurological diagnosis \u0026 age-consistent neuropathology only","divisions":[{"label":"Title","span":{"begin":0,"end":40}}],"tracks":[]}