PMC:2427286 / 8491-9693 JSONTXT

{"project":"2_test","denotations":[{"id":"18374297-10353916-2052363","span":{"begin":681,"end":683},"obj":"10353916"},{"id":"18374297-11287657-2052364","span":{"begin":685,"end":687},"obj":"11287657"},{"id":"18374297-17301231-2052365","span":{"begin":689,"end":691},"obj":"17301231"},{"id":"18374297-16410317-2052366","span":{"begin":693,"end":695},"obj":"16410317"},{"id":"18374297-16510781-2052367","span":{"begin":697,"end":699},"obj":"16510781"},{"id":"18374297-11404349-2052368","span":{"begin":701,"end":703},"obj":"11404349"}],"text":"We wished to calculate the probability that a haplotype could increase from a deduced initial frequency to an observed current frequency by chance over a period specified by the historical record. In addition, we wished to evaluate the influence that admixture with an outside population might have on this probability. We had detailed data consisting of Y-SNP and Y-STR sets for some relevant groups and relied upon the YHRD database for data from other populations. A number of applications are available for estimating migration rates; these applications account for coalescence, mutation, and migration, including estimates of variation of migration, over a period of time.32, 33, 34, 35, 36, 37, 38 However, none of the packages address the specific question of testing whether drift alone could reasonably account for the emergence of modern levels of haplogroup or haplotype frequencies in the population or how much migration for a specified epoch could affect these rates if the available historical information is incorporated. We have therefore chosen to directly employ a Wright-Fisher model with sampled migration to compute the effects of drift given an admixture event of known duration."}