PMC:2427286 / 20704-22181 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2427286","sourcedb":"PMC","sourceid":"2427286","source_url":"https://www.ncbi.nlm.nih.gov/pmc/2427286","text":"Because this Lebanese occurrence lies far outside the normal range of this haplotype, we investigated how likely a haplotype was to rise to this frequency by chance. The first test considered the chances of observing modern levels of the WES1 haplotype among Lebanese Christians without any migration. No WES1 members were found in \u003e1,000 Middle Eastern individuals in the YHRD. Making the highly conservative assumption that its frequency p0 in the Middle East outside the Lebanese Christians was ∼0.1% (the maximum observed size consistent with zero in the sample) and a male effective population size of NL ≈1000 for the Lebanese Christians estimated from our data with BATWING, we calculated the probability of observing the modern fraction f of 2% or more as \u003c0.02 (Material and Methods). In contrast, given an input of western Europeans, selected from an evolving effective population NE ≈5000, who were carrying WES1 at 0.21% (the weighted average of the YHRD frequencies from England, France, Germany, and Italy), the probability of reaching 2% or more among Lebanese Christians exceeded 0.05 for an admixing population fraction m of ∼10.6% or greater (Table 7). It has been assumed that a total of 32 generations have passed since the start of the admixture event44, with mixing only during the first seven generations. Thus, WES1 is likely to have originated in western Europe and shows exactly the pattern expected for a European lineage introduced by the Crusaders.","tracks":[{"project":"2_test","denotations":[{"id":"18374297-15795887-2052373","span":{"begin":1272,"end":1274},"obj":"15795887"}],"attributes":[{"subj":"18374297-15795887-2052373","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#aa93ec","default":true}]}]}}